BindingDB Reactant_set_id	Ligand SMILES	Ligand InChI	Ligand InChI Key	BindingDB MonomerID	BindingDB Ligand Name	Target Name	Target Source Organism According to Curator or DataSource	Ki (nM)	IC50 (nM)	Kd (nM)	EC50 (nM)	kon (M-1-s-1)	koff (s-1)	pH	Temp (C)	Curation/DataSource	Article DOI	BindingDB Entry DOI	PMID	PubChem AID	Patent Number	Authors	Date of publication	Date in BindingDB	Institution	Link to Ligand in BindingDB	Link to Target in BindingDB	Link to Ligand-Target Pair in BindingDB	Ligand HET ID in PDB	PDB ID(s) for Ligand-Target Complex	PubChem CID	PubChem SID	ChEBI ID of Ligand	ChEMBL ID of Ligand	DrugBank ID of Ligand	IUPHAR_GRAC ID of Ligand	KEGG ID of Ligand	ZINC ID of Ligand	Number of Protein Chains in Target (>1 implies a multichain complex)	BindingDB Target Chain Sequence 1	PDB ID(s) of Target Chain 1	UniProt (SwissProt) Recommended Name of Target Chain 1	UniProt (SwissProt) Entry Name of Target Chain 1	UniProt (SwissProt) Primary ID of Target Chain 1	UniProt (SwissProt) Secondary ID(s) of Target Chain 1	UniProt (SwissProt) Alternative ID(s) of Target Chain 1	UniProt (TrEMBL) Submitted Name of Target Chain 1	UniProt (TrEMBL) Entry Name of Target Chain 1	UniProt (TrEMBL) Primary ID of Target Chain 1	UniProt (TrEMBL) Secondary ID(s) of Target Chain 1	UniProt (TrEMBL) Alternative ID(s) of Target Chain 1	BindingDB Target Chain Sequence 2	PDB ID(s) of Target Chain 2	UniProt (SwissProt) Recommended Name of Target Chain 2	UniProt (SwissProt) Entry Name of Target Chain 2	UniProt (SwissProt) Primary ID of Target Chain 2	UniProt (SwissProt) Secondary ID(s) of Target Chain 2	UniProt (SwissProt) Alternative ID(s) of Target Chain 2	UniProt (TrEMBL) Submitted Name of Target Chain 2	UniProt (TrEMBL) Entry Name of Target Chain 2	UniProt (TrEMBL) Primary ID of Target Chain 2	UniProt (TrEMBL) Secondary ID(s) of Target Chain 2	UniProt (TrEMBL) Alternative ID(s) of Target Chain 2	BindingDB Target Chain Sequence 3	PDB ID(s) of Target Chain 3	UniProt (SwissProt) Recommended Name of Target Chain 3	UniProt (SwissProt) Entry Name of Target Chain 3	UniProt (SwissProt) Primary ID of Target Chain 3	UniProt (SwissProt) Secondary ID(s) of Target Chain 3	UniProt (SwissProt) Alternative ID(s) of Target Chain 3	UniProt (TrEMBL) Submitted Name of Target Chain 3	UniProt (TrEMBL) Entry Name of Target Chain 3	UniProt (TrEMBL) Primary ID of Target Chain 3	UniProt (TrEMBL) Secondary ID(s) of Target Chain 3	UniProt (TrEMBL) Alternative ID(s) of Target Chain 3	BindingDB Target Chain Sequence 4	PDB ID(s) of Target Chain 4	UniProt (SwissProt) Recommended Name of Target Chain 4	UniProt (SwissProt) Entry Name of Target Chain 4	UniProt (SwissProt) Primary ID of Target Chain 4	UniProt (SwissProt) Secondary ID(s) of Target Chain 4	UniProt (SwissProt) Alternative ID(s) of Target Chain 4	UniProt (TrEMBL) Submitted Name of Target Chain 4	UniProt (TrEMBL) Entry Name of Target Chain 4	UniProt (TrEMBL) Primary ID of Target Chain 4	UniProt (TrEMBL) Secondary ID(s) of Target Chain 4	UniProt (TrEMBL) Alternative ID(s) of Target Chain 4	BindingDB Target Chain Sequence 5	PDB ID(s) of Target Chain 5	UniProt (SwissProt) Recommended Name of Target Chain 5	UniProt (SwissProt) Entry Name of Target Chain 5	UniProt (SwissProt) Primary ID of Target Chain 5	UniProt (SwissProt) Secondary ID(s) of Target Chain 5	UniProt (SwissProt) Alternative ID(s) of Target Chain 5	UniProt (TrEMBL) Submitted Name of Target Chain 5	UniProt (TrEMBL) Entry Name of Target Chain 5	UniProt (TrEMBL) Primary ID of Target Chain 5	UniProt (TrEMBL) Secondary ID(s) of Target Chain 5	UniProt (TrEMBL) Alternative ID(s) of Target Chain 5	BindingDB Target Chain Sequence 6	PDB ID(s) of Target Chain 6	UniProt (SwissProt) Recommended Name of Target Chain 6	UniProt (SwissProt) Entry Name of Target Chain 6	UniProt (SwissProt) Primary ID of Target Chain 6	UniProt (SwissProt) Secondary ID(s) of Target Chain 6	UniProt (SwissProt) Alternative ID(s) of Target Chain 6	UniProt (TrEMBL) Submitted Name of Target Chain 6	UniProt (TrEMBL) Entry Name of Target Chain 6	UniProt (TrEMBL) Primary ID of Target Chain 6	UniProt (TrEMBL) Secondary ID(s) of Target Chain 6	UniProt (TrEMBL) Alternative ID(s) of Target Chain 6	BindingDB Target Chain Sequence 7	PDB ID(s) of Target Chain 7	UniProt (SwissProt) Recommended Name of Target Chain 7	UniProt (SwissProt) Entry Name of Target Chain 7	UniProt (SwissProt) Primary ID of Target Chain 7	UniProt (SwissProt) Secondary ID(s) of Target Chain 7	UniProt (SwissProt) Alternative ID(s) of Target Chain 7	UniProt (TrEMBL) Submitted Name of Target Chain 7	UniProt (TrEMBL) Entry Name of Target Chain 7	UniProt (TrEMBL) Primary ID of Target Chain 7	UniProt (TrEMBL) Secondary ID(s) of Target Chain 7	UniProt (TrEMBL) Alternative ID(s) of Target Chain 7	BindingDB Target Chain Sequence 8	PDB ID(s) of Target Chain 8	UniProt (SwissProt) Recommended Name of Target Chain 8	UniProt (SwissProt) Entry Name of Target Chain 8	UniProt (SwissProt) Primary ID of Target Chain 8	UniProt (SwissProt) Secondary ID(s) of Target Chain 8	UniProt (SwissProt) Alternative ID(s) of Target Chain 8	UniProt (TrEMBL) Submitted Name of Target Chain 8	UniProt (TrEMBL) Entry Name of Target Chain 8	UniProt (TrEMBL) Primary ID of Target Chain 8	UniProt (TrEMBL) Secondary ID(s) of Target Chain 8	UniProt (TrEMBL) Alternative ID(s) of Target Chain 8	BindingDB Target Chain Sequence 9	PDB ID(s) of Target Chain 9	UniProt (SwissProt) Recommended Name of Target Chain 9	UniProt (SwissProt) Entry Name of Target Chain 9	UniProt (SwissProt) Primary ID of Target Chain 9	UniProt (SwissProt) Secondary ID(s) of Target Chain 9	UniProt (SwissProt) Alternative ID(s) of Target Chain 9	UniProt (TrEMBL) Submitted Name of Target Chain 9	UniProt (TrEMBL) Entry Name of Target Chain 9	UniProt (TrEMBL) Primary ID of Target Chain 9	UniProt (TrEMBL) Secondary ID(s) of Target Chain 9	UniProt (TrEMBL) Alternative ID(s) of Target Chain 9	BindingDB Target Chain Sequence 10	PDB ID(s) of Target Chain 10	UniProt (SwissProt) Recommended Name of Target Chain 10	UniProt (SwissProt) Entry Name of Target Chain 10	UniProt (SwissProt) Primary ID of Target Chain 10	UniProt (SwissProt) Secondary ID(s) of Target Chain 10	UniProt (SwissProt) Alternative ID(s) of Target Chain 10	UniProt (TrEMBL) Submitted Name of Target Chain 10	UniProt (TrEMBL) Entry Name of Target Chain 10	UniProt (TrEMBL) Primary ID of Target Chain 10	UniProt (TrEMBL) Secondary ID(s) of Target Chain 10	UniProt (TrEMBL) Alternative ID(s) of Target Chain 10	BindingDB Target Chain Sequence 11	PDB ID(s) of Target Chain 11	UniProt (SwissProt) Recommended Name of Target Chain 11	UniProt (SwissProt) Entry Name of Target Chain 11	UniProt (SwissProt) Primary ID of Target Chain 11	UniProt (SwissProt) Secondary ID(s) of Target Chain 11	UniProt (SwissProt) Alternative ID(s) of Target Chain 11	UniProt (TrEMBL) Submitted Name of Target Chain 11	UniProt (TrEMBL) Entry Name of Target Chain 11	UniProt (TrEMBL) Primary ID of Target Chain 11	UniProt (TrEMBL) Secondary ID(s) of Target Chain 11	UniProt (TrEMBL) Alternative ID(s) of Target Chain 11	BindingDB Target Chain Sequence 12	PDB ID(s) of Target Chain 12	UniProt (SwissProt) Recommended Name of Target Chain 12	UniProt (SwissProt) Entry Name of Target Chain 12	UniProt (SwissProt) Primary ID of Target Chain 12	UniProt (SwissProt) Secondary ID(s) of Target Chain 12	UniProt (SwissProt) Alternative ID(s) of Target Chain 12	UniProt (TrEMBL) Submitted Name of Target Chain 12	UniProt (TrEMBL) Entry Name of Target Chain 12	UniProt (TrEMBL) Primary ID of Target Chain 12	UniProt (TrEMBL) Secondary ID(s) of Target Chain 12	UniProt (TrEMBL) Alternative ID(s) of Target Chain 12	BindingDB Target Chain Sequence 13	PDB ID(s) of Target Chain 13	UniProt (SwissProt) Recommended Name of Target Chain 13	UniProt (SwissProt) Entry Name of Target Chain 13	UniProt (SwissProt) Primary ID of Target Chain 13	UniProt (SwissProt) Secondary ID(s) of Target Chain 13	UniProt (SwissProt) Alternative ID(s) of Target Chain 13	UniProt (TrEMBL) Submitted Name of Target Chain 13	UniProt (TrEMBL) Entry Name of Target Chain 13	UniProt (TrEMBL) Primary ID of Target Chain 13	UniProt (TrEMBL) Secondary ID(s) of Target Chain 13	UniProt (TrEMBL) Alternative ID(s) of Target Chain 13	BindingDB Target Chain Sequence 14	PDB ID(s) of Target Chain 14	UniProt (SwissProt) Recommended Name of Target Chain 14	UniProt (SwissProt) Entry Name of Target Chain 14	UniProt (SwissProt) Primary ID of Target Chain 14	UniProt (SwissProt) Secondary ID(s) of Target Chain 14	UniProt (SwissProt) Alternative ID(s) of Target Chain 14	UniProt (TrEMBL) Submitted Name of Target Chain 14	UniProt (TrEMBL) Entry Name of Target Chain 14	UniProt (TrEMBL) Primary ID of Target Chain 14	UniProt (TrEMBL) Secondary ID(s) of Target Chain 14	UniProt (TrEMBL) Alternative ID(s) of Target Chain 14	BindingDB Target Chain Sequence 15	PDB ID(s) of Target Chain 15	UniProt (SwissProt) Recommended Name of Target Chain 15	UniProt (SwissProt) Entry Name of Target Chain 15	UniProt (SwissProt) Primary ID of Target Chain 15	UniProt (SwissProt) Secondary ID(s) of Target Chain 15	UniProt (SwissProt) Alternative ID(s) of Target Chain 15	UniProt (TrEMBL) Submitted Name of Target Chain 15	UniProt (TrEMBL) Entry Name of Target Chain 15	UniProt (TrEMBL) Primary ID of Target Chain 15	UniProt (TrEMBL) Secondary ID(s) of Target Chain 15	UniProt (TrEMBL) Alternative ID(s) of Target Chain 15	BindingDB Target Chain Sequence 16	PDB ID(s) of Target Chain 16	UniProt (SwissProt) Recommended Name of Target Chain 16	UniProt (SwissProt) Entry Name of Target Chain 16	UniProt (SwissProt) Primary ID of Target Chain 16	UniProt (SwissProt) Secondary ID(s) of Target Chain 16	UniProt (SwissProt) Alternative ID(s) of Target Chain 16	UniProt (TrEMBL) Submitted Name of Target Chain 16	UniProt (TrEMBL) Entry Name of Target Chain 16	UniProt (TrEMBL) Primary ID of Target Chain 16	UniProt (TrEMBL) Secondary ID(s) of Target Chain 16	UniProt (TrEMBL) Alternative ID(s) of Target Chain 16	BindingDB Target Chain Sequence 17	PDB ID(s) of Target Chain 17	UniProt (SwissProt) Recommended Name of Target Chain 17	UniProt (SwissProt) Entry Name of Target Chain 17	UniProt (SwissProt) Primary ID of Target Chain 17	UniProt (SwissProt) Secondary ID(s) of Target Chain 17	UniProt (SwissProt) Alternative ID(s) of Target Chain 17	UniProt (TrEMBL) Submitted Name of Target Chain 17	UniProt (TrEMBL) Entry Name of Target Chain 17	UniProt (TrEMBL) Primary ID of Target Chain 17	UniProt (TrEMBL) Secondary ID(s) of Target Chain 17	UniProt (TrEMBL) Alternative ID(s) of Target Chain 17	BindingDB Target Chain Sequence 18	PDB ID(s) of Target Chain 18	UniProt (SwissProt) Recommended Name of Target Chain 18	UniProt (SwissProt) Entry Name of Target Chain 18	UniProt (SwissProt) Primary ID of Target Chain 18	UniProt (SwissProt) Secondary ID(s) of Target Chain 18	UniProt (SwissProt) Alternative ID(s) of Target Chain 18	UniProt (TrEMBL) Submitted Name of Target Chain 18	UniProt (TrEMBL) Entry Name of Target Chain 18	UniProt (TrEMBL) Primary ID of Target Chain 18	UniProt (TrEMBL) Secondary ID(s) of Target Chain 18	UniProt (TrEMBL) Alternative ID(s) of Target Chain 18	BindingDB Target Chain Sequence 19	PDB ID(s) of Target Chain 19	UniProt (SwissProt) Recommended Name of Target Chain 19	UniProt (SwissProt) Entry Name of Target Chain 19	UniProt (SwissProt) Primary ID of Target Chain 19	UniProt (SwissProt) Secondary ID(s) of Target Chain 19	UniProt (SwissProt) Alternative ID(s) of Target Chain 19	UniProt (TrEMBL) Submitted Name of Target Chain 19	UniProt (TrEMBL) Entry Name of Target Chain 19	UniProt (TrEMBL) Primary ID of Target Chain 19	UniProt (TrEMBL) Secondary ID(s) of Target Chain 19	UniProt (TrEMBL) Alternative ID(s) of Target Chain 19	BindingDB Target Chain Sequence 20	PDB ID(s) of Target Chain 20	UniProt (SwissProt) Recommended Name of Target Chain 20	UniProt (SwissProt) Entry Name of Target Chain 20	UniProt (SwissProt) Primary ID of Target Chain 20	UniProt (SwissProt) Secondary ID(s) of Target Chain 20	UniProt (SwissProt) Alternative ID(s) of Target Chain 20	UniProt (TrEMBL) Submitted Name of Target Chain 20	UniProt (TrEMBL) Entry Name of Target Chain 20	UniProt (TrEMBL) Primary ID of Target Chain 20	UniProt (TrEMBL) Secondary ID(s) of Target Chain 20	UniProt (TrEMBL) Alternative ID(s) of Target Chain 20	BindingDB Target Chain Sequence 21	PDB ID(s) of Target Chain 21	UniProt (SwissProt) Recommended Name of Target Chain 21	UniProt (SwissProt) Entry Name of Target Chain 21	UniProt (SwissProt) Primary ID of Target Chain 21	UniProt (SwissProt) Secondary ID(s) of Target Chain 21	UniProt (SwissProt) Alternative ID(s) of Target Chain 21	UniProt (TrEMBL) Submitted Name of Target Chain 21	UniProt (TrEMBL) Entry Name of Target Chain 21	UniProt (TrEMBL) Primary ID of Target Chain 21	UniProt (TrEMBL) Secondary ID(s) of Target Chain 21	UniProt (TrEMBL) Alternative ID(s) of Target Chain 21	BindingDB Target Chain Sequence 22	PDB ID(s) of Target Chain 22	UniProt (SwissProt) Recommended Name of Target Chain 22	UniProt (SwissProt) Entry Name of Target Chain 22	UniProt (SwissProt) Primary ID of Target Chain 22	UniProt (SwissProt) Secondary ID(s) of Target Chain 22	UniProt (SwissProt) Alternative ID(s) of Target Chain 22	UniProt (TrEMBL) Submitted Name of Target Chain 22	UniProt (TrEMBL) Entry Name of Target Chain 22	UniProt (TrEMBL) Primary ID of Target Chain 22	UniProt (TrEMBL) Secondary ID(s) of Target Chain 22	UniProt (TrEMBL) Alternative ID(s) of Target Chain 22	BindingDB Target Chain Sequence 23	PDB ID(s) of Target Chain 23	UniProt (SwissProt) Recommended Name of Target Chain 23	UniProt (SwissProt) Entry Name of Target Chain 23	UniProt (SwissProt) Primary ID of Target Chain 23	UniProt (SwissProt) Secondary ID(s) of Target Chain 23	UniProt (SwissProt) Alternative ID(s) of Target Chain 23	UniProt (TrEMBL) Submitted Name of Target Chain 23	UniProt (TrEMBL) Entry Name of Target Chain 23	UniProt (TrEMBL) Primary ID of Target Chain 23	UniProt (TrEMBL) Secondary ID(s) of Target Chain 23	UniProt (TrEMBL) Alternative ID(s) of Target Chain 23	BindingDB Target Chain Sequence 24	PDB ID(s) of Target Chain 24	UniProt (SwissProt) Recommended Name of Target Chain 24	UniProt (SwissProt) Entry Name of Target Chain 24	UniProt (SwissProt) Primary ID of Target Chain 24	UniProt (SwissProt) Secondary ID(s) of Target Chain 24	UniProt (SwissProt) Alternative ID(s) of Target Chain 24	UniProt (TrEMBL) Submitted Name of Target Chain 24	UniProt (TrEMBL) Entry Name of Target Chain 24	UniProt (TrEMBL) Primary ID of Target Chain 24	UniProt (TrEMBL) Secondary ID(s) of Target Chain 24	UniProt (TrEMBL) Alternative ID(s) of Target Chain 24	BindingDB Target Chain Sequence 25	PDB ID(s) of Target Chain 25	UniProt (SwissProt) Recommended Name of Target Chain 25	UniProt (SwissProt) Entry Name of Target Chain 25	UniProt (SwissProt) Primary ID of Target Chain 25	UniProt (SwissProt) Secondary ID(s) of Target Chain 25	UniProt (SwissProt) Alternative ID(s) of Target Chain 25	UniProt (TrEMBL) Submitted Name of Target Chain 25	UniProt (TrEMBL) Entry Name of Target Chain 25	UniProt (TrEMBL) Primary ID of Target Chain 25	UniProt (TrEMBL) Secondary ID(s) of Target Chain 25	UniProt (TrEMBL) Alternative ID(s) of Target Chain 25	BindingDB Target Chain Sequence 26	PDB ID(s) of Target Chain 26	UniProt (SwissProt) Recommended Name of Target Chain 26	UniProt (SwissProt) Entry Name of Target Chain 26	UniProt (SwissProt) Primary ID of Target Chain 26	UniProt (SwissProt) Secondary ID(s) of Target Chain 26	UniProt (SwissProt) Alternative ID(s) of Target Chain 26	UniProt (TrEMBL) Submitted Name of Target Chain 26	UniProt (TrEMBL) Entry Name of Target Chain 26	UniProt (TrEMBL) Primary ID of Target Chain 26	UniProt (TrEMBL) Secondary ID(s) of Target Chain 26	UniProt (TrEMBL) Alternative ID(s) of Target Chain 26	BindingDB Target Chain Sequence 27	PDB ID(s) of Target Chain 27	UniProt (SwissProt) Recommended Name of Target Chain 27	UniProt (SwissProt) Entry Name of Target Chain 27	UniProt (SwissProt) Primary ID of Target Chain 27	UniProt (SwissProt) Secondary ID(s) of Target Chain 27	UniProt (SwissProt) Alternative ID(s) of Target Chain 27	UniProt (TrEMBL) Submitted Name of Target Chain 27	UniProt (TrEMBL) Entry Name of Target Chain 27	UniProt (TrEMBL) Primary ID of Target Chain 27	UniProt (TrEMBL) Secondary ID(s) of Target Chain 27	UniProt (TrEMBL) Alternative ID(s) of Target Chain 27	BindingDB Target Chain Sequence 28	PDB ID(s) of Target Chain 28	UniProt (SwissProt) Recommended Name of Target Chain 28	UniProt (SwissProt) Entry Name of Target Chain 28	UniProt (SwissProt) Primary ID of Target Chain 28	UniProt (SwissProt) Secondary ID(s) of Target Chain 28	UniProt (SwissProt) Alternative ID(s) of Target Chain 28	UniProt (TrEMBL) Submitted Name of Target Chain 28	UniProt (TrEMBL) Entry Name of Target Chain 28	UniProt (TrEMBL) Primary ID of Target Chain 28	UniProt (TrEMBL) Secondary ID(s) of Target Chain 28	UniProt (TrEMBL) Alternative ID(s) of Target Chain 28	BindingDB Target Chain Sequence 29	PDB ID(s) of Target Chain 29	UniProt (SwissProt) Recommended Name of Target Chain 29	UniProt (SwissProt) Entry Name of Target Chain 29	UniProt (SwissProt) Primary ID of Target Chain 29	UniProt (SwissProt) Secondary ID(s) of Target Chain 29	UniProt (SwissProt) Alternative ID(s) of Target Chain 29	UniProt (TrEMBL) Submitted Name of Target Chain 29	UniProt (TrEMBL) Entry Name of Target Chain 29	UniProt (TrEMBL) Primary ID of Target Chain 29	UniProt (TrEMBL) Secondary ID(s) of Target Chain 29	UniProt (TrEMBL) Alternative ID(s) of Target Chain 29	BindingDB Target Chain Sequence 30	PDB ID(s) of Target Chain 30	UniProt (SwissProt) Recommended Name of Target Chain 30	UniProt (SwissProt) Entry Name of Target Chain 30	UniProt (SwissProt) Primary ID of Target Chain 30	UniProt (SwissProt) Secondary ID(s) of Target Chain 30	UniProt (SwissProt) Alternative ID(s) of Target Chain 30	UniProt (TrEMBL) Submitted Name of Target Chain 30	UniProt (TrEMBL) Entry Name of Target Chain 30	UniProt (TrEMBL) Primary ID of Target Chain 30	UniProt (TrEMBL) Secondary ID(s) of Target Chain 30	UniProt (TrEMBL) Alternative ID(s) of Target Chain 30	BindingDB Target Chain Sequence 31	PDB ID(s) of Target Chain 31	UniProt (SwissProt) Recommended Name of Target Chain 31	UniProt (SwissProt) Entry Name of Target Chain 31	UniProt (SwissProt) Primary ID of Target Chain 31	UniProt (SwissProt) Secondary ID(s) of Target Chain 31	UniProt (SwissProt) Alternative ID(s) of Target Chain 31	UniProt (TrEMBL) Submitted Name of Target Chain 31	UniProt (TrEMBL) Entry Name of Target Chain 31	UniProt (TrEMBL) Primary ID of Target Chain 31	UniProt (TrEMBL) Secondary ID(s) of Target Chain 31	UniProt (TrEMBL) Alternative ID(s) of Target Chain 31	BindingDB Target Chain Sequence 32	PDB ID(s) of Target Chain 32	UniProt (SwissProt) Recommended Name of Target Chain 32	UniProt (SwissProt) Entry Name of Target Chain 32	UniProt (SwissProt) Primary ID of Target Chain 32	UniProt (SwissProt) Secondary ID(s) of Target Chain 32	UniProt (SwissProt) Alternative ID(s) of Target Chain 32	UniProt (TrEMBL) Submitted Name of Target Chain 32	UniProt (TrEMBL) Entry Name of Target Chain 32	UniProt (TrEMBL) Primary ID of Target Chain 32	UniProt (TrEMBL) Secondary ID(s) of Target Chain 32	UniProt (TrEMBL) Alternative ID(s) of Target Chain 32	BindingDB Target Chain Sequence 33	PDB ID(s) of Target Chain 33	UniProt (SwissProt) Recommended Name of Target Chain 33	UniProt (SwissProt) Entry Name of Target Chain 33	UniProt (SwissProt) Primary ID of Target Chain 33	UniProt (SwissProt) Secondary ID(s) of Target Chain 33	UniProt (SwissProt) Alternative ID(s) of Target Chain 33	UniProt (TrEMBL) Submitted Name of Target Chain 33	UniProt (TrEMBL) Entry Name of Target Chain 33	UniProt (TrEMBL) Primary ID of Target Chain 33	UniProt (TrEMBL) Secondary ID(s) of Target Chain 33	UniProt (TrEMBL) Alternative ID(s) of Target Chain 33	BindingDB Target Chain Sequence 34	PDB ID(s) of Target Chain 34	UniProt (SwissProt) Recommended Name of Target Chain 34	UniProt (SwissProt) Entry Name of Target Chain 34	UniProt (SwissProt) Primary ID of Target Chain 34	UniProt (SwissProt) Secondary ID(s) of Target Chain 34	UniProt (SwissProt) Alternative ID(s) of Target Chain 34	UniProt (TrEMBL) Submitted Name of Target Chain 34	UniProt (TrEMBL) Entry Name of Target Chain 34	UniProt (TrEMBL) Primary ID of Target Chain 34	UniProt (TrEMBL) Secondary ID(s) of Target Chain 34	UniProt (TrEMBL) Alternative ID(s) of Target Chain 34	BindingDB Target Chain Sequence 35	PDB ID(s) of Target Chain 35	UniProt (SwissProt) Recommended Name of Target Chain 35	UniProt (SwissProt) Entry Name of Target Chain 35	UniProt (SwissProt) Primary ID of Target Chain 35	UniProt (SwissProt) Secondary ID(s) of Target Chain 35	UniProt (SwissProt) Alternative ID(s) of Target Chain 35	UniProt (TrEMBL) Submitted Name of Target Chain 35	UniProt (TrEMBL) Entry Name of Target Chain 35	UniProt (TrEMBL) Primary ID of Target Chain 35	UniProt (TrEMBL) Secondary ID(s) of Target Chain 35	UniProt (TrEMBL) Alternative ID(s) of Target Chain 35	BindingDB Target Chain Sequence 36	PDB ID(s) of Target Chain 36	UniProt (SwissProt) Recommended Name of Target Chain 36	UniProt (SwissProt) Entry Name of Target Chain 36	UniProt (SwissProt) Primary ID of Target Chain 36	UniProt (SwissProt) Secondary ID(s) of Target Chain 36	UniProt (SwissProt) Alternative ID(s) of Target Chain 36	UniProt (TrEMBL) Submitted Name of Target Chain 36	UniProt (TrEMBL) Entry Name of Target Chain 36	UniProt (TrEMBL) Primary ID of Target Chain 36	UniProt (TrEMBL) Secondary ID(s) of Target Chain 36	UniProt (TrEMBL) Alternative ID(s) of Target Chain 36	BindingDB Target Chain Sequence 37	PDB ID(s) of Target Chain 37	UniProt (SwissProt) Recommended Name of Target Chain 37	UniProt (SwissProt) Entry Name of Target Chain 37	UniProt (SwissProt) Primary ID of Target Chain 37	UniProt (SwissProt) Secondary ID(s) of Target Chain 37	UniProt (SwissProt) Alternative ID(s) of Target Chain 37	UniProt (TrEMBL) Submitted Name of Target Chain 37	UniProt (TrEMBL) Entry Name of Target Chain 37	UniProt (TrEMBL) Primary ID of Target Chain 37	UniProt (TrEMBL) Secondary ID(s) of Target Chain 37	UniProt (TrEMBL) Alternative ID(s) of Target Chain 37	BindingDB Target Chain Sequence 38	PDB ID(s) of Target Chain 38	UniProt (SwissProt) Recommended Name of Target Chain 38	UniProt (SwissProt) Entry Name of Target Chain 38	UniProt (SwissProt) Primary ID of Target Chain 38	UniProt (SwissProt) Secondary ID(s) of Target Chain 38	UniProt (SwissProt) Alternative ID(s) of Target Chain 38	UniProt (TrEMBL) Submitted Name of Target Chain 38	UniProt (TrEMBL) Entry Name of Target Chain 38	UniProt (TrEMBL) Primary ID of Target Chain 38	UniProt (TrEMBL) Secondary ID(s) of Target Chain 38	UniProt (TrEMBL) Alternative ID(s) of Target Chain 38	BindingDB Target Chain Sequence 39	PDB ID(s) of Target Chain 39	UniProt (SwissProt) Recommended Name of Target Chain 39	UniProt (SwissProt) Entry Name of Target Chain 39	UniProt (SwissProt) Primary ID of Target Chain 39	UniProt (SwissProt) Secondary ID(s) of Target Chain 39	UniProt (SwissProt) Alternative ID(s) of Target Chain 39	UniProt (TrEMBL) Submitted Name of Target Chain 39	UniProt (TrEMBL) Entry Name of Target Chain 39	UniProt (TrEMBL) Primary ID of Target Chain 39	UniProt (TrEMBL) Secondary ID(s) of Target Chain 39	UniProt (TrEMBL) Alternative ID(s) of Target Chain 39	BindingDB Target Chain Sequence 40	PDB ID(s) of Target Chain 40	UniProt (SwissProt) Recommended Name of Target Chain 40	UniProt (SwissProt) Entry Name of Target Chain 40	UniProt (SwissProt) Primary ID of Target Chain 40	UniProt (SwissProt) Secondary ID(s) of Target Chain 40	UniProt (SwissProt) Alternative ID(s) of Target Chain 40	UniProt (TrEMBL) Submitted Name of Target Chain 40	UniProt (TrEMBL) Entry Name of Target Chain 40	UniProt (TrEMBL) Primary ID of Target Chain 40	UniProt (TrEMBL) Secondary ID(s) of Target Chain 40	UniProt (TrEMBL) Alternative ID(s) of Target Chain 40	BindingDB Target Chain Sequence 41	PDB ID(s) of Target Chain 41	UniProt (SwissProt) Recommended Name of Target Chain 41	UniProt (SwissProt) Entry Name of Target Chain 41	UniProt (SwissProt) Primary ID of Target Chain 41	UniProt (SwissProt) Secondary ID(s) of Target Chain 41	UniProt (SwissProt) Alternative ID(s) of Target Chain 41	UniProt (TrEMBL) Submitted Name of Target Chain 41	UniProt (TrEMBL) Entry Name of Target Chain 41	UniProt (TrEMBL) Primary ID of Target Chain 41	UniProt (TrEMBL) Secondary ID(s) of Target Chain 41	UniProt (TrEMBL) Alternative ID(s) of Target Chain 41	BindingDB Target Chain Sequence 42	PDB ID(s) of Target Chain 42	UniProt (SwissProt) Recommended Name of Target Chain 42	UniProt (SwissProt) Entry Name of Target Chain 42	UniProt (SwissProt) Primary ID of Target Chain 42	UniProt (SwissProt) Secondary ID(s) of Target Chain 42	UniProt (SwissProt) Alternative ID(s) of Target Chain 42	UniProt (TrEMBL) Submitted Name of Target Chain 42	UniProt (TrEMBL) Entry Name of Target Chain 42	UniProt (TrEMBL) Primary ID of Target Chain 42	UniProt (TrEMBL) Secondary ID(s) of Target Chain 42	UniProt (TrEMBL) Alternative ID(s) of Target Chain 42	BindingDB Target Chain Sequence 43	PDB ID(s) of Target Chain 43	UniProt (SwissProt) Recommended Name of Target Chain 43	UniProt (SwissProt) Entry Name of Target Chain 43	UniProt (SwissProt) Primary ID of Target Chain 43	UniProt (SwissProt) Secondary ID(s) of Target Chain 43	UniProt (SwissProt) Alternative ID(s) of Target Chain 43	UniProt (TrEMBL) Submitted Name of Target Chain 43	UniProt (TrEMBL) Entry Name of Target Chain 43	UniProt (TrEMBL) Primary ID of Target Chain 43	UniProt (TrEMBL) Secondary ID(s) of Target Chain 43	UniProt (TrEMBL) Alternative ID(s) of Target Chain 43	BindingDB Target Chain Sequence 44	PDB ID(s) of Target Chain 44	UniProt (SwissProt) Recommended Name of Target Chain 44	UniProt (SwissProt) Entry Name of Target Chain 44	UniProt (SwissProt) Primary ID of Target Chain 44	UniProt (SwissProt) Secondary ID(s) of Target Chain 44	UniProt (SwissProt) Alternative ID(s) of Target Chain 44	UniProt (TrEMBL) Submitted Name of Target Chain 44	UniProt (TrEMBL) Entry Name of Target Chain 44	UniProt (TrEMBL) Primary ID of Target Chain 44	UniProt (TrEMBL) Secondary ID(s) of Target Chain 44	UniProt (TrEMBL) Alternative ID(s) of Target Chain 44	BindingDB Target Chain Sequence 45	PDB ID(s) of Target Chain 45	UniProt (SwissProt) Recommended Name of Target Chain 45	UniProt (SwissProt) Entry Name of Target Chain 45	UniProt (SwissProt) Primary ID of Target Chain 45	UniProt (SwissProt) Secondary ID(s) of Target Chain 45	UniProt (SwissProt) Alternative ID(s) of Target Chain 45	UniProt (TrEMBL) Submitted Name of Target Chain 45	UniProt (TrEMBL) Entry Name of Target Chain 45	UniProt (TrEMBL) Primary ID of Target Chain 45	UniProt (TrEMBL) Secondary ID(s) of Target Chain 45	UniProt (TrEMBL) Alternative ID(s) of Target Chain 45	BindingDB Target Chain Sequence 46	PDB ID(s) of Target Chain 46	UniProt (SwissProt) Recommended Name of Target Chain 46	UniProt (SwissProt) Entry Name of Target Chain 46	UniProt (SwissProt) Primary ID of Target Chain 46	UniProt (SwissProt) Secondary ID(s) of Target Chain 46	UniProt (SwissProt) Alternative ID(s) of Target Chain 46	UniProt (TrEMBL) Submitted Name of Target Chain 46	UniProt (TrEMBL) Entry Name of Target Chain 46	UniProt (TrEMBL) Primary ID of Target Chain 46	UniProt (TrEMBL) Secondary ID(s) of Target Chain 46	UniProt (TrEMBL) Alternative ID(s) of Target Chain 46	BindingDB Target Chain Sequence 47	PDB ID(s) of Target Chain 47	UniProt (SwissProt) Recommended Name of Target Chain 47	UniProt (SwissProt) Entry Name of Target Chain 47	UniProt (SwissProt) Primary ID of Target Chain 47	UniProt (SwissProt) Secondary ID(s) of Target Chain 47	UniProt (SwissProt) Alternative ID(s) of Target Chain 47	UniProt (TrEMBL) Submitted Name of Target Chain 47	UniProt (TrEMBL) Entry Name of Target Chain 47	UniProt (TrEMBL) Primary ID of Target Chain 47	UniProt (TrEMBL) Secondary ID(s) of Target Chain 47	UniProt (TrEMBL) Alternative ID(s) of Target Chain 47	BindingDB Target Chain Sequence 48	PDB ID(s) of Target Chain 48	UniProt (SwissProt) Recommended Name of Target Chain 48	UniProt (SwissProt) Entry Name of Target Chain 48	UniProt (SwissProt) Primary ID of Target Chain 48	UniProt (SwissProt) Secondary ID(s) of Target Chain 48	UniProt (SwissProt) Alternative ID(s) of Target Chain 48	UniProt (TrEMBL) Submitted Name of Target Chain 48	UniProt (TrEMBL) Entry Name of Target Chain 48	UniProt (TrEMBL) Primary ID of Target Chain 48	UniProt (TrEMBL) Secondary ID(s) of Target Chain 48	UniProt (TrEMBL) Alternative ID(s) of Target Chain 48	BindingDB Target Chain Sequence 49	PDB ID(s) of Target Chain 49	UniProt (SwissProt) Recommended Name of Target Chain 49	UniProt (SwissProt) Entry Name of Target Chain 49	UniProt (SwissProt) Primary ID of Target Chain 49	UniProt (SwissProt) Secondary ID(s) of Target Chain 49	UniProt (SwissProt) Alternative ID(s) of Target Chain 49	UniProt (TrEMBL) Submitted Name of Target Chain 49	UniProt (TrEMBL) Entry Name of Target Chain 49	UniProt (TrEMBL) Primary ID of Target Chain 49	UniProt (TrEMBL) Secondary ID(s) of Target Chain 49	UniProt (TrEMBL) Alternative ID(s) of Target Chain 49	BindingDB Target Chain Sequence 50	PDB ID(s) of Target Chain 50	UniProt (SwissProt) Recommended Name of Target Chain 50	UniProt (SwissProt) Entry Name of Target Chain 50	UniProt (SwissProt) Primary ID of Target Chain 50	UniProt (SwissProt) Secondary ID(s) of Target Chain 50	UniProt (SwissProt) Alternative ID(s) of Target Chain 50	UniProt (TrEMBL) Submitted Name of Target Chain 50	UniProt (TrEMBL) Entry Name of Target Chain 50	UniProt (TrEMBL) Primary ID of Target Chain 50	UniProt (TrEMBL) Secondary ID(s) of Target Chain 50	UniProt (TrEMBL) Alternative ID(s) of Target Chain 50
740804	Cc1nc(C(=O)N2CCCCC2CNc2ncc(cn2)C(F)(F)F)c(s1)-c1ccc(F)cc1	InChI=1S/C22H21F4N5OS/c1-13-30-18(19(33-13)14-5-7-16(23)8-6-14)20(32)31-9-3-2-4-17(31)12-29-21-27-10-15(11-28-21)22(24,25)26/h5-8,10-11,17H,2-4,9,12H2,1H3,(H,27,28,29)	HTPYTUYMFPPZFG-UHFFFAOYSA-N	373132	US9896452, SR-12376	Orexin/Hypocretin receptor type 1	Homo sapiens		 13.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373132	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373132&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117732745	404342237							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740805	Cc1nc(C(=O)N2CCCCC2CNc2ncc(cn2)C(F)(F)F)c(s1)-c1ccc(F)cc1	InChI=1S/C22H21F4N5OS/c1-13-30-18(19(33-13)14-5-7-16(23)8-6-14)20(32)31-9-3-2-4-17(31)12-29-21-27-10-15(11-28-21)22(24,25)26/h5-8,10-11,17H,2-4,9,12H2,1H3,(H,27,28,29)	HTPYTUYMFPPZFG-UHFFFAOYSA-N	373132	US9896452, SR-12376	Orexin receptor type 2	Homo sapiens		 70.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373132	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373132&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117732745	404342237							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740806	C[C@@H]1CCCN([C@@H]1CNc1ncc(cn1)C(F)(F)F)C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C23H23F4N5OS/c1-13-4-3-9-32(18(13)12-30-22-28-10-16(11-29-22)23(25,26)27)21(33)19-20(34-14(2)31-19)15-5-7-17(24)8-6-15/h5-8,10-11,13,18H,3-4,9,12H2,1-2H3,(H,28,29,30)/t13-,18-/m1/s1	BPQDADCPUWZLIG-FZKQIMNGSA-N	373133	US9896452, Example 75::rac-((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone	Orexin/Hypocretin receptor type 1	Homo sapiens		 3.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373133	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373133&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			71715611	404342238							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740807	C[C@@H]1CCCN([C@@H]1CNc1ncc(cn1)C(F)(F)F)C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C23H23F4N5OS/c1-13-4-3-9-32(18(13)12-30-22-28-10-16(11-29-22)23(25,26)27)21(33)19-20(34-14(2)31-19)15-5-7-17(24)8-6-15/h5-8,10-11,13,18H,3-4,9,12H2,1-2H3,(H,28,29,30)/t13-,18-/m1/s1	BPQDADCPUWZLIG-FZKQIMNGSA-N	373133	US9896452, Example 75::rac-((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone	Orexin receptor type 2	Homo sapiens		 3279							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373133	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373133&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			71715611	404342238							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740808	C[C@H]1CCCN([C@@H]1CNc1ncc(cn1)C(F)(F)F)C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C23H23F4N5OS/c1-13-4-3-9-32(18(13)12-30-22-28-10-16(11-29-22)23(25,26)27)21(33)19-20(34-14(2)31-19)15-5-7-17(24)8-6-15/h5-8,10-11,13,18H,3-4,9,12H2,1-2H3,(H,28,29,30)/t13-,18+/m0/s1	BPQDADCPUWZLIG-SCLBCKFNSA-N	373134	(5-(4-fluorophenyl)-2-methylthiazol-4-yl)((2S,3S)-3-methyl-2-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidin-1-yl)methanone::US9896452, Ex. A311	Orexin/Hypocretin receptor type 1	Homo sapiens		 27.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373134	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373134&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117732716	404342239							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740809	C[C@H]1CCCN([C@@H]1CNc1ncc(cn1)C(F)(F)F)C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C23H23F4N5OS/c1-13-4-3-9-32(18(13)12-30-22-28-10-16(11-29-22)23(25,26)27)21(33)19-20(34-14(2)31-19)15-5-7-17(24)8-6-15/h5-8,10-11,13,18H,3-4,9,12H2,1-2H3,(H,28,29,30)/t13-,18+/m0/s1	BPQDADCPUWZLIG-SCLBCKFNSA-N	373134	(5-(4-fluorophenyl)-2-methylthiazol-4-yl)((2S,3S)-3-methyl-2-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidin-1-yl)methanone::US9896452, Ex. A311	Orexin receptor type 2	Homo sapiens		 3092							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373134	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373134&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117732716	404342239							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740810	Cc1nc(C(=O)N2CCCC(C)(C)C2CNc2ncc(cn2)C(F)(F)F)c(s1)-c1ccc(F)cc1	InChI=1S/C24H25F4N5OS/c1-14-32-19(20(35-14)15-5-7-17(25)8-6-15)21(34)33-10-4-9-23(2,3)18(33)13-31-22-29-11-16(12-30-22)24(26,27)28/h5-8,11-12,18H,4,9-10,13H2,1-3H3,(H,29,30,31)	VSWRFUIHMUFEJQ-UHFFFAOYSA-N	373135	US9896452, SR-12364	Orexin/Hypocretin receptor type 1	Homo sapiens		 137							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373135	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373135&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117732737	404342240							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740811	Cc1nc(C(=O)N2CCCC(C)(C)C2CNc2ncc(cn2)C(F)(F)F)c(s1)-c1ccc(F)cc1	InChI=1S/C24H25F4N5OS/c1-14-32-19(20(35-14)15-5-7-17(25)8-6-15)21(34)33-10-4-9-23(2,3)18(33)13-31-22-29-11-16(12-30-22)24(26,27)28/h5-8,11-12,18H,4,9-10,13H2,1-3H3,(H,29,30,31)	VSWRFUIHMUFEJQ-UHFFFAOYSA-N	373135	US9896452, SR-12364	Orexin receptor type 2	Homo sapiens		 2637							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373135	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373135&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117732737	404342240							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740812	Cc1nc(C(=O)N2CC(F)CCC2CNC(=O)c2cccc3cccnc23)c(s1)-c1ccccc1	InChI=1S/C27H25FN4O2S/c1-17-31-24(25(35-17)19-7-3-2-4-8-19)27(34)32-16-20(28)12-13-21(32)15-30-26(33)22-11-5-9-18-10-6-14-29-23(18)22/h2-11,14,20-21H,12-13,15-16H2,1H3,(H,30,33)	BSPIQLLFYKKPND-UHFFFAOYSA-N	373136	US9896452, Example 1::rac-N-((5-fluoro-1-(2-methyl-5-phenylthiazole-4-carbonyl)piperidin-2-yl)methyl)quinoline-8-carboxamide	Orexin/Hypocretin receptor type 1	Homo sapiens		 1.000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373136	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373136&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			71715781	404342241							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740813	Cc1nc(C(=O)N2CC(F)CCC2CNC(=O)c2cccc3cccnc23)c(s1)-c1ccccc1	InChI=1S/C27H25FN4O2S/c1-17-31-24(25(35-17)19-7-3-2-4-8-19)27(34)32-16-20(28)12-13-21(32)15-30-26(33)22-11-5-9-18-10-6-14-29-23(18)22/h2-11,14,20-21H,12-13,15-16H2,1H3,(H,30,33)	BSPIQLLFYKKPND-UHFFFAOYSA-N	373136	US9896452, Example 1::rac-N-((5-fluoro-1-(2-methyl-5-phenylthiazole-4-carbonyl)piperidin-2-yl)methyl)quinoline-8-carboxamide	Orexin receptor type 2	Homo sapiens		 8.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373136	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373136&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			71715781	404342241							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740814	Cc1nc(C(=O)N2CC(F)CCC2CNC(=O)c2cccc3occc23)c(s1)-c1ccccc1	InChI=1S/C26H24FN3O3S/c1-16-29-23(24(34-16)17-6-3-2-4-7-17)26(32)30-15-18(27)10-11-19(30)14-28-25(31)21-8-5-9-22-20(21)12-13-33-22/h2-9,12-13,18-19H,10-11,14-15H2,1H3,(H,28,31)	MOXXGRCLAOBXLS-UHFFFAOYSA-N	373137	US9896452, Example 2::rac-N-((5-fluoro-1-(2-methyl-5-phenylthiazole-4-carbonyl)piperidin-2-yl)methyl)benzofuran-4-carboxamide	Orexin/Hypocretin receptor type 1	Homo sapiens		 1.000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373137	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373137&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			71715782	404342242							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740815	Cc1nc(C(=O)N2CC(F)CCC2CNC(=O)c2cccc3occc23)c(s1)-c1ccccc1	InChI=1S/C26H24FN3O3S/c1-16-29-23(24(34-16)17-6-3-2-4-7-17)26(32)30-15-18(27)10-11-19(30)14-28-25(31)21-8-5-9-22-20(21)12-13-33-22/h2-9,12-13,18-19H,10-11,14-15H2,1H3,(H,28,31)	MOXXGRCLAOBXLS-UHFFFAOYSA-N	373137	US9896452, Example 2::rac-N-((5-fluoro-1-(2-methyl-5-phenylthiazole-4-carbonyl)piperidin-2-yl)methyl)benzofuran-4-carboxamide	Orexin receptor type 2	Homo sapiens		 7.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373137	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373137&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			71715782	404342242							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740816	Cc1nc(C(=O)N2CC(F)CCC2CNc2ccc(cn2)C(F)(F)F)c(s1)-c1ccccc1	InChI=1S/C23H22F4N4OS/c1-14-30-20(21(33-14)15-5-3-2-4-6-15)22(32)31-13-17(24)8-9-18(31)12-29-19-10-7-16(11-28-19)23(25,26)27/h2-7,10-11,17-18H,8-9,12-13H2,1H3,(H,28,29)	GJDYBOVHDFWUGD-UHFFFAOYSA-N	373138	US9896452, Example 3::rac-(5-Fluoro-2-((5-(trifluoromethyl)pyridin-2-ylamino)methyl)piperidin-1-yl)(2-methyl-5-phenylthiazol-4-yl)methanone	Orexin/Hypocretin receptor type 1	Homo sapiens		 2.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373138	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373138&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			71715783	404342243							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740817	Cc1nc(C(=O)N2CC(F)CCC2CNc2ccc(cn2)C(F)(F)F)c(s1)-c1ccccc1	InChI=1S/C23H22F4N4OS/c1-14-30-20(21(33-14)15-5-3-2-4-6-15)22(32)31-13-17(24)8-9-18(31)12-29-19-10-7-16(11-28-19)23(25,26)27/h2-7,10-11,17-18H,8-9,12-13H2,1H3,(H,28,29)	GJDYBOVHDFWUGD-UHFFFAOYSA-N	373138	US9896452, Example 3::rac-(5-Fluoro-2-((5-(trifluoromethyl)pyridin-2-ylamino)methyl)piperidin-1-yl)(2-methyl-5-phenylthiazol-4-yl)methanone	Orexin receptor type 2	Homo sapiens		 36.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373138	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373138&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			71715783	404342243							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740818	O[C@@H]1C[C@@H](CNC(=O)c2cccc3cccnc23)N(C1)C(=O)c1ccccc1-c1ccccc1	InChI=1S/C28H25N3O3/c32-22-16-21(17-30-27(33)25-14-6-10-20-11-7-15-29-26(20)25)31(18-22)28(34)24-13-5-4-12-23(24)19-8-2-1-3-9-19/h1-15,21-22,32H,16-18H2,(H,30,33)/t21-,22+/m0/s1	DGPPIHXUBWXOKZ-FCHUYYIVSA-N	373139	N-((2S,4R)-1-(Biphenylcarbonyl)-4-hydroxypyrrolidin-2-yl)methyl)quinoline-8-carboxamide::US9896452, Example 4	Orexin/Hypocretin receptor type 1	Homo sapiens		 88.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373139	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373139&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89739415	404342244							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740819	O[C@@H]1C[C@@H](CNC(=O)c2cccc3cccnc23)N(C1)C(=O)c1ccccc1-c1ccccc1	InChI=1S/C28H25N3O3/c32-22-16-21(17-30-27(33)25-14-6-10-20-11-7-15-29-26(20)25)31(18-22)28(34)24-13-5-4-12-23(24)19-8-2-1-3-9-19/h1-15,21-22,32H,16-18H2,(H,30,33)/t21-,22+/m0/s1	DGPPIHXUBWXOKZ-FCHUYYIVSA-N	373139	N-((2S,4R)-1-(Biphenylcarbonyl)-4-hydroxypyrrolidin-2-yl)methyl)quinoline-8-carboxamide::US9896452, Example 4	Orexin receptor type 2	Homo sapiens		 1000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373139	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373139&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			89739415	404342244							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740820	F[C@H]1C[C@@H](CNC(=O)c2cccc3cccnc23)N(C1)C(=O)c1ccccc1-c1ccccc1	InChI=1S/C28H24FN3O2/c29-21-16-22(17-31-27(33)25-14-6-10-20-11-7-15-30-26(20)25)32(18-21)28(34)24-13-5-4-12-23(24)19-8-2-1-3-9-19/h1-15,21-22H,16-18H2,(H,31,33)/t21-,22-/m0/s1	QTPNZRYZZTWQMZ-VXKWHMMOSA-N	373140	N-(((2S,4S)-1-(Biphenylcarbonyl)-4-fluoropyrrolidin-2-yl)methyl)quinoline-8-carboxamide::US9896452, Example 5	Orexin/Hypocretin receptor type 1	Homo sapiens		 6.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373140	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373140&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			71715839	404342245							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740821	F[C@H]1C[C@@H](CNC(=O)c2cccc3cccnc23)N(C1)C(=O)c1ccccc1-c1ccccc1	InChI=1S/C28H24FN3O2/c29-21-16-22(17-31-27(33)25-14-6-10-20-11-7-15-30-26(20)25)32(18-21)28(34)24-13-5-4-12-23(24)19-8-2-1-3-9-19/h1-15,21-22H,16-18H2,(H,31,33)/t21-,22-/m0/s1	QTPNZRYZZTWQMZ-VXKWHMMOSA-N	373140	N-(((2S,4S)-1-(Biphenylcarbonyl)-4-fluoropyrrolidin-2-yl)methyl)quinoline-8-carboxamide::US9896452, Example 5	Orexin receptor type 2	Homo sapiens		 40.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373140	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373140&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			71715839	404342245							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740822	O=C(NC[C@@H]1CC(=O)CN1C(=O)c1ccccc1-c1ccccc1)c1cccc2cccnc12	InChI=1S/C28H23N3O3/c32-22-16-21(17-30-27(33)25-14-6-10-20-11-7-15-29-26(20)25)31(18-22)28(34)24-13-5-4-12-23(24)19-8-2-1-3-9-19/h1-15,21H,16-18H2,(H,30,33)/t21-/m0/s1	KECRXHHEZOOQQI-NRFANRHFSA-N	373141	(S)-N-((1-(Biphenylcarbonyl)-4-oxopyrrolidin-2-yl)methyl)quinoline-8-carboxamide::US9896452, Example 6	Orexin/Hypocretin receptor type 1	Homo sapiens		 30.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373141	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373141&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			71715840	404342246							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740823	O=C(NC[C@@H]1CC(=O)CN1C(=O)c1ccccc1-c1ccccc1)c1cccc2cccnc12	InChI=1S/C28H23N3O3/c32-22-16-21(17-30-27(33)25-14-6-10-20-11-7-15-29-26(20)25)31(18-22)28(34)24-13-5-4-12-23(24)19-8-2-1-3-9-19/h1-15,21H,16-18H2,(H,30,33)/t21-/m0/s1	KECRXHHEZOOQQI-NRFANRHFSA-N	373141	(S)-N-((1-(Biphenylcarbonyl)-4-oxopyrrolidin-2-yl)methyl)quinoline-8-carboxamide::US9896452, Example 6	Orexin receptor type 2	Homo sapiens		 700							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373141	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373141&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			71715840	404342246							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740824	FC1(F)C[C@@H](CNC(=O)c2cccc3cccnc23)N(C1)C(=O)c1ccccc1-c1ccccc1	InChI=1S/C28H23F2N3O2/c29-28(30)16-21(17-32-26(34)24-14-6-10-20-11-7-15-31-25(20)24)33(18-28)27(35)23-13-5-4-12-22(23)19-8-2-1-3-9-19/h1-15,21H,16-18H2,(H,32,34)/t21-/m0/s1	ORGZMHDPBVQARK-NRFANRHFSA-N	373142	(S)-N-((1-(Biphenylcarbonyl)-4,4-difluoropyrrolidin-2-yl)methyl)quinoline-8-carboxamide::US9896452, Example 7	Orexin/Hypocretin receptor type 1	Homo sapiens		 150							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373142	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373142&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			71715841	404342247							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740825	FC1(F)C[C@@H](CNC(=O)c2cccc3cccnc23)N(C1)C(=O)c1ccccc1-c1ccccc1	InChI=1S/C28H23F2N3O2/c29-28(30)16-21(17-32-26(34)24-14-6-10-20-11-7-15-31-25(20)24)33(18-28)27(35)23-13-5-4-12-22(23)19-8-2-1-3-9-19/h1-15,21H,16-18H2,(H,32,34)/t21-/m0/s1	ORGZMHDPBVQARK-NRFANRHFSA-N	373142	(S)-N-((1-(Biphenylcarbonyl)-4,4-difluoropyrrolidin-2-yl)methyl)quinoline-8-carboxamide::US9896452, Example 7	Orexin receptor type 2	Homo sapiens		 75.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373142	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373142&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			71715841	404342247							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740826	C[C@@H]1CCCN([C@@H]1CNC(=O)c1cccc2cccnc12)C(=O)c1nc(C)sc1-c1ccccc1	InChI=1S/C28H28N4O2S/c1-18-9-8-16-32(28(34)25-26(35-19(2)31-25)21-10-4-3-5-11-21)23(18)17-30-27(33)22-14-6-12-20-13-7-15-29-24(20)22/h3-7,10-15,18,23H,8-9,16-17H2,1-2H3,(H,30,33)/t18-,23-/m1/s1	SRKVUFVTSRBFFN-WZONZLPQSA-N	50384428	CHEMBL2031491::US9896452, Example 8	Orexin/Hypocretin receptor type 1	Homo sapiens		 3.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50384428	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50384428&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			70690041	160863511		CHEMBL2031491				ZINC84651981	1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740827	C[C@@H]1CCCN([C@@H]1CNC(=O)c1cccc2cccnc12)C(=O)c1nc(C)sc1-c1ccccc1	InChI=1S/C28H28N4O2S/c1-18-9-8-16-32(28(34)25-26(35-19(2)31-25)21-10-4-3-5-11-21)23(18)17-30-27(33)22-14-6-12-20-13-7-15-29-24(20)22/h3-7,10-15,18,23H,8-9,16-17H2,1-2H3,(H,30,33)/t18-,23-/m1/s1	SRKVUFVTSRBFFN-WZONZLPQSA-N	50384428	CHEMBL2031491::US9896452, Example 8	Orexin receptor type 2	Homo sapiens		 60.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50384428	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50384428&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			70690041	160863511		CHEMBL2031491				ZINC84651981	1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740828	C[C@@H]1CCCN([C@@H]1CNC(=O)c1cccc2cccnc12)C(=O)c1sc(C)nc1-c1ccccc1	InChI=1S/C28H28N4O2S/c1-18-9-8-16-32(28(34)26-25(31-19(2)35-26)21-10-4-3-5-11-21)23(18)17-30-27(33)22-14-6-12-20-13-7-15-29-24(20)22/h3-7,10-15,18,23H,8-9,16-17H2,1-2H3,(H,30,33)/t18-,23-/m1/s1	BURFUOOYZMGYEH-WZONZLPQSA-N	50384426	CHEMBL2031489::US9896452, Example 9	Orexin/Hypocretin receptor type 1	Homo sapiens		 15.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50384426	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50384426&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			70685887	160863509		CHEMBL2031489				ZINC84759401	1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740829	C[C@@H]1CCCN([C@@H]1CNC(=O)c1cccc2cccnc12)C(=O)c1sc(C)nc1-c1ccccc1	InChI=1S/C28H28N4O2S/c1-18-9-8-16-32(28(34)26-25(31-19(2)35-26)21-10-4-3-5-11-21)23(18)17-30-27(33)22-14-6-12-20-13-7-15-29-24(20)22/h3-7,10-15,18,23H,8-9,16-17H2,1-2H3,(H,30,33)/t18-,23-/m1/s1	BURFUOOYZMGYEH-WZONZLPQSA-N	50384426	CHEMBL2031489::US9896452, Example 9	Orexin receptor type 2	Homo sapiens		 85.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50384426	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50384426&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			70685887	160863509		CHEMBL2031489				ZINC84759401	1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740830	COc1c(F)cccc1C(=O)N1CCC[C@@H](C)[C@H]1CNC(=O)c1cccc2cccnc12	InChI=1S/C25H26FN3O3/c1-16-7-6-14-29(25(31)19-11-4-12-20(26)23(19)32-2)21(16)15-28-24(30)18-10-3-8-17-9-5-13-27-22(17)18/h3-5,8-13,16,21H,6-7,14-15H2,1-2H3,(H,28,30)/t16-,21-/m1/s1	KYGCYXKOKJGNFP-IIBYNOLFSA-N	373146	US9896452, Example 10::rac-N-(((2S,3R)-1-(3-Fluoro-2-methoxybenzoyl)-3-methylpiperidin-2-yl)methyl)quinoline-8-carboxamide	Orexin/Hypocretin receptor type 1	Homo sapiens		<3000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373146	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373146&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89748236	404342250							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740831	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C24H24F4N4OS/c1-14-4-3-11-32(19(14)13-30-20-10-7-17(12-29-20)24(26,27)28)23(33)21-22(34-15(2)31-21)16-5-8-18(25)9-6-16/h5-10,12,14,19H,3-4,11,13H2,1-2H3,(H,29,30)/t14-,19-/m1/s1	SVCKMOGUOXOQCC-AUUYWEPGSA-N	373147	US9896452, Ex. A85::US9896452, Example 11::rac-(5-(4-fluorophenyl)-2-methylthiazol-4-yl)((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)methanone	Orexin/Hypocretin receptor type 1	Homo sapiens		 8.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373147	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373147&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89748213	404342251							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740832	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C24H24F4N4OS/c1-14-4-3-11-32(19(14)13-30-20-10-7-17(12-29-20)24(26,27)28)23(33)21-22(34-15(2)31-21)16-5-8-18(25)9-6-16/h5-10,12,14,19H,3-4,11,13H2,1-2H3,(H,29,30)/t14-,19-/m1/s1	SVCKMOGUOXOQCC-AUUYWEPGSA-N	373147	US9896452, Ex. A85::US9896452, Example 11::rac-(5-(4-fluorophenyl)-2-methylthiazol-4-yl)((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)methanone	Orexin receptor type 2	Homo sapiens		 4900							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373147	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373147&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			89748213	404342251							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740833	C[C@@H]1CCCN([C@@H]1CNc1nc2ccccc2o1)C(=O)c1nc(C)sc1-c1ccccc1	InChI=1S/C25H26N4O2S/c1-16-9-8-14-29(20(16)15-26-25-28-19-12-6-7-13-21(19)31-25)24(30)22-23(32-17(2)27-22)18-10-4-3-5-11-18/h3-7,10-13,16,20H,8-9,14-15H2,1-2H3,(H,26,28)/t16-,20-/m1/s1	DOCDYUJINMSGRS-OXQOHEQNSA-N	50384430	CHEMBL2031493::US9896452, Example 12	Orexin/Hypocretin receptor type 1	Homo sapiens		 4.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50384430	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50384430&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			70685888	160863513		CHEMBL2031493				ZINC84655069	1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740834	C[C@@H]1CCCN([C@@H]1CNc1nc2ccccc2o1)C(=O)c1nc(C)sc1-c1ccccc1	InChI=1S/C25H26N4O2S/c1-16-9-8-14-29(20(16)15-26-25-28-19-12-6-7-13-21(19)31-25)24(30)22-23(32-17(2)27-22)18-10-4-3-5-11-18/h3-7,10-13,16,20H,8-9,14-15H2,1-2H3,(H,26,28)/t16-,20-/m1/s1	DOCDYUJINMSGRS-OXQOHEQNSA-N	50384430	CHEMBL2031493::US9896452, Example 12	Orexin receptor type 2	Homo sapiens		 450							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50384430	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50384430&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			70685888	160863513		CHEMBL2031493				ZINC84655069	1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740835	Cc1nc(C(=O)N2CCC[C@H]([C@H]2CNc2nc3ccccc3o2)C(F)(F)F)c(s1)-c1ccccc1	InChI=1S/C25H23F3N4O2S/c1-15-30-21(22(35-15)16-8-3-2-4-9-16)23(33)32-13-7-10-17(25(26,27)28)19(32)14-29-24-31-18-11-5-6-12-20(18)34-24/h2-6,8-9,11-12,17,19H,7,10,13-14H2,1H3,(H,29,31)/t17-,19-/m1/s1	XTDVOZHNKIHADA-IEBWSBKVSA-N	373151	US9896452, Example 13::rac-((2S,3R)-2-((benzo[d]oxazol-2-ylamino)methyl)-3-(trifluoromethyl)piperidin-1-yl)(2-methyl-5-phenylthiazol-4-yl)methanone	Orexin/Hypocretin receptor type 1	Homo sapiens		 9.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373151	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373151&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89748237	404342253							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740836	Cc1nc(C(=O)N2CCC[C@H]([C@H]2CNc2nc3ccccc3o2)C(F)(F)F)c(s1)-c1ccccc1	InChI=1S/C25H23F3N4O2S/c1-15-30-21(22(35-15)16-8-3-2-4-9-16)23(33)32-13-7-10-17(25(26,27)28)19(32)14-29-24-31-18-11-5-6-12-20(18)34-24/h2-6,8-9,11-12,17,19H,7,10,13-14H2,1H3,(H,29,31)/t17-,19-/m1/s1	XTDVOZHNKIHADA-IEBWSBKVSA-N	373151	US9896452, Example 13::rac-((2S,3R)-2-((benzo[d]oxazol-2-ylamino)methyl)-3-(trifluoromethyl)piperidin-1-yl)(2-methyl-5-phenylthiazol-4-yl)methanone	Orexin receptor type 2	Homo sapiens		 220							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373151	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373151&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			89748237	404342253							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740837	Cc1nc(C(=O)N2CCC[C@H]([C@H]2CNc2ccc(cn2)C(F)(F)F)C(F)(F)F)c(s1)-c1ccccc1	InChI=1S/C24H22F6N4OS/c1-14-33-20(21(36-14)15-6-3-2-4-7-15)22(35)34-11-5-8-17(24(28,29)30)18(34)13-32-19-10-9-16(12-31-19)23(25,26)27/h2-4,6-7,9-10,12,17-18H,5,8,11,13H2,1H3,(H,31,32)/t17-,18-/m1/s1	YFBCVCHBTLLJNL-QZTJIDSGSA-N	373152	US9896452, Example 14::rac-(2-methyl-5-phenylthiazol-4-yl)((2S,3R)-3-(trifluoromethyl)-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)methanone	Orexin/Hypocretin receptor type 1	Homo sapiens		 9.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373152	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373152&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89739456	404342254							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740838	Cc1nc(C(=O)N2CCC[C@H]([C@H]2CNc2ccc(cn2)C(F)(F)F)C(F)(F)F)c(s1)-c1ccccc1	InChI=1S/C24H22F6N4OS/c1-14-33-20(21(36-14)15-6-3-2-4-7-15)22(35)34-11-5-8-17(24(28,29)30)18(34)13-32-19-10-9-16(12-31-19)23(25,26)27/h2-4,6-7,9-10,12,17-18H,5,8,11,13H2,1H3,(H,31,32)/t17-,18-/m1/s1	YFBCVCHBTLLJNL-QZTJIDSGSA-N	373152	US9896452, Example 14::rac-(2-methyl-5-phenylthiazol-4-yl)((2S,3R)-3-(trifluoromethyl)-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)methanone	Orexin receptor type 2	Homo sapiens		 460							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373152	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373152&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			89739456	404342254							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740839	C[C@@H]1CCCN([C@@H]1CNc1ncc(Br)cn1)C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C22H23BrFN5OS/c1-13-4-3-9-29(18(13)12-27-22-25-10-16(23)11-26-22)21(30)19-20(31-14(2)28-19)15-5-7-17(24)8-6-15/h5-8,10-11,13,18H,3-4,9,12H2,1-2H3,(H,25,26,27)/t13-,18-/m1/s1	ISPRXWJTTDEODA-FZKQIMNGSA-N	373153	US9896452, Example 15::rac-((2S,3R)-2-(((5-bromopyrimidin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone	Orexin/Hypocretin receptor type 1	Homo sapiens		 1.000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373153	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373153&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89740691	404342255							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740840	C[C@@H]1CCCN([C@@H]1CNc1ncc(Br)cn1)C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C22H23BrFN5OS/c1-13-4-3-9-29(18(13)12-27-22-25-10-16(23)11-26-22)21(30)19-20(31-14(2)28-19)15-5-7-17(24)8-6-15/h5-8,10-11,13,18H,3-4,9,12H2,1-2H3,(H,25,26,27)/t13-,18-/m1/s1	ISPRXWJTTDEODA-FZKQIMNGSA-N	373153	US9896452, Example 15::rac-((2S,3R)-2-(((5-bromopyrimidin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373153	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373153&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			89740691	404342255							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740841	CCc1cnc(NC[C@@H]2[C@H](C)CCCN2C(=O)c2nc(C)sc2-c2ccc(F)cc2)nc1	InChI=1S/C24H28FN5OS/c1-4-17-12-26-24(27-13-17)28-14-20-15(2)6-5-11-30(20)23(31)21-22(32-16(3)29-21)18-7-9-19(25)10-8-18/h7-10,12-13,15,20H,4-6,11,14H2,1-3H3,(H,26,27,28)/t15-,20-/m1/s1	UWCLPLRBLDMNBO-FOIQADDNSA-N	373154	US9896452, Example 16::rac-((2S,3R)-2-(((5-ethylpyrimidin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone	Orexin/Hypocretin receptor type 1	Homo sapiens		 8.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373154	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373154&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89739635	404342256							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740842	CCc1cnc(NC[C@@H]2[C@H](C)CCCN2C(=O)c2nc(C)sc2-c2ccc(F)cc2)nc1	InChI=1S/C24H28FN5OS/c1-4-17-12-26-24(27-13-17)28-14-20-15(2)6-5-11-30(20)23(31)21-22(32-16(3)29-21)18-7-9-19(25)10-8-18/h7-10,12-13,15,20H,4-6,11,14H2,1-3H3,(H,26,27,28)/t15-,20-/m1/s1	UWCLPLRBLDMNBO-FOIQADDNSA-N	373154	US9896452, Example 16::rac-((2S,3R)-2-(((5-ethylpyrimidin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone	Orexin receptor type 2	Homo sapiens		>10000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373154	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373154&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			89739635	404342256							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740843	COc1ccnc(NC[C@@H]2[C@H](C)CCCN2C(=O)c2nc(C)sc2-c2ccc(F)cc2)n1	InChI=1S/C23H26FN5O2S/c1-14-5-4-12-29(18(14)13-26-23-25-11-10-19(28-23)31-3)22(30)20-21(32-15(2)27-20)16-6-8-17(24)9-7-16/h6-11,14,18H,4-5,12-13H2,1-3H3,(H,25,26,28)/t14-,18-/m1/s1	TXGLTMLQAMLILJ-RDTXWAMCSA-N	373155	US9896452, Example 17::rac-(5-(4-fluorophenyl)-2-methylthiazol-4-yl)((2S,3R)-2-(((4-methoxypyrimidin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)methanone	Orexin/Hypocretin receptor type 1	Homo sapiens		 52.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373155	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373155&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89748225	404342257							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740844	COc1ccnc(NC[C@@H]2[C@H](C)CCCN2C(=O)c2nc(C)sc2-c2ccc(F)cc2)n1	InChI=1S/C23H26FN5O2S/c1-14-5-4-12-29(18(14)13-26-23-25-11-10-19(28-23)31-3)22(30)20-21(32-15(2)27-20)16-6-8-17(24)9-7-16/h6-11,14,18H,4-5,12-13H2,1-3H3,(H,25,26,28)/t14-,18-/m1/s1	TXGLTMLQAMLILJ-RDTXWAMCSA-N	373155	US9896452, Example 17::rac-(5-(4-fluorophenyl)-2-methylthiazol-4-yl)((2S,3R)-2-(((4-methoxypyrimidin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)methanone	Orexin receptor type 2	Homo sapiens		 1800							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373155	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373155&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			89748225	404342257							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740845	C[C@@H]1CCCN([C@@H]1CNc1ccc(Cl)cn1)C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C23H24ClFN4OS/c1-14-4-3-11-29(19(14)13-27-20-10-7-17(24)12-26-20)23(30)21-22(31-15(2)28-21)16-5-8-18(25)9-6-16/h5-10,12,14,19H,3-4,11,13H2,1-2H3,(H,26,27)/t14-,19-/m1/s1	RQFJEZZFXLTNSI-AUUYWEPGSA-N	373156	US9896452, Example 18::rac-((2S,3R)-2-(((5-chloropyridin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone	Orexin/Hypocretin receptor type 1	Homo sapiens		 16.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373156	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373156&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89739245	404342258							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740846	C[C@@H]1CCCN([C@@H]1CNc1ccc(Cl)cn1)C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C23H24ClFN4OS/c1-14-4-3-11-29(19(14)13-27-20-10-7-17(24)12-26-20)23(30)21-22(31-15(2)28-21)16-5-8-18(25)9-6-16/h5-10,12,14,19H,3-4,11,13H2,1-2H3,(H,26,27)/t14-,19-/m1/s1	RQFJEZZFXLTNSI-AUUYWEPGSA-N	373156	US9896452, Example 18::rac-((2S,3R)-2-(((5-chloropyridin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone	Orexin receptor type 2	Homo sapiens		 1500							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373156	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373156&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			89739245	404342258							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740847	C[C@@H]1CCCN([C@@H]1CNc1ccnc(Cl)n1)C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C22H23ClFN5OS/c1-13-4-3-11-29(17(13)12-26-18-9-10-25-22(23)28-18)21(30)19-20(31-14(2)27-19)15-5-7-16(24)8-6-15/h5-10,13,17H,3-4,11-12H2,1-2H3,(H,25,26,28)/t13-,17-/m1/s1	XFEYGGDAAUEMDY-CXAGYDPISA-N	373157	US9896452, Example 19::rac-((2S,3R)-2-(((2-chloropyrimidin-4-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone	Orexin/Hypocretin receptor type 1	Homo sapiens		 270							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373157	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373157&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89748238	404342259							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740848	C[C@@H]1CCCN([C@@H]1CNc1ccnc(Cl)n1)C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C22H23ClFN5OS/c1-13-4-3-11-29(17(13)12-26-18-9-10-25-22(23)28-18)21(30)19-20(31-14(2)27-19)15-5-7-16(24)8-6-15/h5-10,13,17H,3-4,11-12H2,1-2H3,(H,25,26,28)/t13-,17-/m1/s1	XFEYGGDAAUEMDY-CXAGYDPISA-N	373157	US9896452, Example 19::rac-((2S,3R)-2-(((2-chloropyrimidin-4-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone	Orexin receptor type 2	Homo sapiens		>10000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373157	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373157&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			89748238	404342259							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740849	C[C@@H]1CCCN([C@@H]1CNc1nccc(Cl)n1)C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C22H23ClFN5OS/c1-13-4-3-11-29(17(13)12-26-22-25-10-9-18(23)28-22)21(30)19-20(31-14(2)27-19)15-5-7-16(24)8-6-15/h5-10,13,17H,3-4,11-12H2,1-2H3,(H,25,26,28)/t13-,17-/m1/s1	ZJTZBERWGFEOEJ-CXAGYDPISA-N	373158	US9896452, Example 20::rac-((2S,3R)-2-(((4-chloropyrimidin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone	Orexin/Hypocretin receptor type 1	Homo sapiens		 1300							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373158	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373158&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89739372	404342260							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740850	C[C@@H]1CCCN([C@@H]1CNc1nccc(Cl)n1)C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C22H23ClFN5OS/c1-13-4-3-11-29(17(13)12-26-22-25-10-9-18(23)28-22)21(30)19-20(31-14(2)27-19)15-5-7-16(24)8-6-15/h5-10,13,17H,3-4,11-12H2,1-2H3,(H,25,26,28)/t13-,17-/m1/s1	ZJTZBERWGFEOEJ-CXAGYDPISA-N	373158	US9896452, Example 20::rac-((2S,3R)-2-(((4-chloropyrimidin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone	Orexin receptor type 2	Homo sapiens		>10000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373158	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373158&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			89739372	404342260							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740851	C[C@@H]1CCCN([C@@H]1CNc1cc(ccn1)C(F)(F)F)C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C24H24F4N4OS/c1-14-4-3-11-32(19(14)13-30-20-12-17(9-10-29-20)24(26,27)28)23(33)21-22(34-15(2)31-21)16-5-7-18(25)8-6-16/h5-10,12,14,19H,3-4,11,13H2,1-2H3,(H,29,30)/t14-,19-/m1/s1	JQISCCGNNAKTQB-AUUYWEPGSA-N	373159	US9896452, Example 21::rac-(5-(4-fluorophenyl)-2-methylthiazol-4-yl)((2S,3R)-3-methyl-2-(((4-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)methanone	Orexin/Hypocretin receptor type 1	Homo sapiens		 24.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373159	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373159&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89748149	404342261							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740852	C[C@@H]1CCCN([C@@H]1CNc1cc(ccn1)C(F)(F)F)C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C24H24F4N4OS/c1-14-4-3-11-32(19(14)13-30-20-12-17(9-10-29-20)24(26,27)28)23(33)21-22(34-15(2)31-21)16-5-7-18(25)8-6-16/h5-10,12,14,19H,3-4,11,13H2,1-2H3,(H,29,30)/t14-,19-/m1/s1	JQISCCGNNAKTQB-AUUYWEPGSA-N	373159	US9896452, Example 21::rac-(5-(4-fluorophenyl)-2-methylthiazol-4-yl)((2S,3R)-3-methyl-2-(((4-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)methanone	Orexin receptor type 2	Homo sapiens		 520							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373159	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373159&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			89748149	404342261							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740853	C[C@@H]1CCCN([C@@H]1CNc1ncccc1C(F)(F)F)C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C24H24F4N4OS/c1-14-5-4-12-32(19(14)13-30-22-18(24(26,27)28)6-3-11-29-22)23(33)20-21(34-15(2)31-20)16-7-9-17(25)10-8-16/h3,6-11,14,19H,4-5,12-13H2,1-2H3,(H,29,30)/t14-,19-/m1/s1	ILZSYNUVFURJGH-AUUYWEPGSA-N	373160	US9896452, Example 22::rac-(5-(4-fluorophenyl)-2-methylthiazol-4-yl)((2S,3R)-3-methyl-2-(((3-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)methanone	Orexin/Hypocretin receptor type 1	Homo sapiens		 82.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373160	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373160&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89748150	404342262							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740854	C[C@@H]1CCCN([C@@H]1CNc1ncccc1C(F)(F)F)C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C24H24F4N4OS/c1-14-5-4-12-32(19(14)13-30-22-18(24(26,27)28)6-3-11-29-22)23(33)20-21(34-15(2)31-20)16-7-9-17(25)10-8-16/h3,6-11,14,19H,4-5,12-13H2,1-2H3,(H,29,30)/t14-,19-/m1/s1	ILZSYNUVFURJGH-AUUYWEPGSA-N	373160	US9896452, Example 22::rac-(5-(4-fluorophenyl)-2-methylthiazol-4-yl)((2S,3R)-3-methyl-2-(((3-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)methanone	Orexin receptor type 2	Homo sapiens		>10000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373160	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373160&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			89748150	404342262							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740855	C[C@@H]1CCCN([C@@H]1CNc1cccc(C)n1)C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C24H27FN4OS/c1-15-6-5-13-29(20(15)14-26-21-8-4-7-16(2)27-21)24(30)22-23(31-17(3)28-22)18-9-11-19(25)12-10-18/h4,7-12,15,20H,5-6,13-14H2,1-3H3,(H,26,27)/t15-,20-/m1/s1	JDJXIYFKTPJOKW-FOIQADDNSA-N	373161	US9896452, Example 23::rac-(5-(4-fluorophenyl)-2-methylthiazol-4-yl)((2S,3R)-3-methyl-2-(((6-methylpyridin-2-yl)amino)methyl)piperidin-1-yl)methanone	Orexin/Hypocretin receptor type 1	Homo sapiens		 60.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373161	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373161&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89740812	404342263							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740856	C[C@@H]1CCCN([C@@H]1CNc1cccc(C)n1)C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C24H27FN4OS/c1-15-6-5-13-29(20(15)14-26-21-8-4-7-16(2)27-21)24(30)22-23(31-17(3)28-22)18-9-11-19(25)12-10-18/h4,7-12,15,20H,5-6,13-14H2,1-3H3,(H,26,27)/t15-,20-/m1/s1	JDJXIYFKTPJOKW-FOIQADDNSA-N	373161	US9896452, Example 23::rac-(5-(4-fluorophenyl)-2-methylthiazol-4-yl)((2S,3R)-3-methyl-2-(((6-methylpyridin-2-yl)amino)methyl)piperidin-1-yl)methanone	Orexin receptor type 2	Homo sapiens		 1400							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373161	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373161&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			89740812	404342263							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740857	C[C@@H]1CCCN([C@@H]1CNc1nc2ccccc2o1)C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C25H25FN4O2S/c1-15-6-5-13-30(20(15)14-27-25-29-19-7-3-4-8-21(19)32-25)24(31)22-23(33-16(2)28-22)17-9-11-18(26)12-10-17/h3-4,7-12,15,20H,5-6,13-14H2,1-2H3,(H,27,29)/t15-,20-/m1/s1	RSCBRJAESFFMDG-FOIQADDNSA-N	373164	US9896452, Example 24::rac-((2S,3R)-2-((benzo[d]oxazol-2-ylamino)methyl)-3-methylpiperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone	Orexin/Hypocretin receptor type 1	Homo sapiens		 4.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373164	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373164&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89748144	404342266							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740858	C[C@@H]1CCCN([C@@H]1CNc1nc2ccccc2o1)C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C25H25FN4O2S/c1-15-6-5-13-30(20(15)14-27-25-29-19-7-3-4-8-21(19)32-25)24(31)22-23(33-16(2)28-22)17-9-11-18(26)12-10-17/h3-4,7-12,15,20H,5-6,13-14H2,1-2H3,(H,27,29)/t15-,20-/m1/s1	RSCBRJAESFFMDG-FOIQADDNSA-N	373164	US9896452, Example 24::rac-((2S,3R)-2-((benzo[d]oxazol-2-ylamino)methyl)-3-methylpiperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone	Orexin receptor type 2	Homo sapiens		 340							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373164	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373164&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			89748144	404342266							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740859	CC1CCCC(CNc2nc3ccccc3o2)N1C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C25H25FN4O2S/c1-15-6-5-7-19(14-27-25-29-20-8-3-4-9-21(20)32-25)30(15)24(31)22-23(33-16(2)28-22)17-10-12-18(26)13-11-17/h3-4,8-13,15,19H,5-7,14H2,1-2H3,(H,27,29)	FVXDIUWLPYTCGR-UHFFFAOYSA-N	373165	US9896452, Example 25::rac-(2-((benzo[d]oxazol-2-ylamino)methyl)-6-methylpiperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone	Orexin/Hypocretin receptor type 1	Homo sapiens		 8.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373165	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373165&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			77914734	404342267							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740860	CC1CCCC(CNc2nc3ccccc3o2)N1C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C25H25FN4O2S/c1-15-6-5-7-19(14-27-25-29-20-8-3-4-9-21(20)32-25)30(15)24(31)22-23(33-16(2)28-22)17-10-12-18(26)13-11-17/h3-4,8-13,15,19H,5-7,14H2,1-2H3,(H,27,29)	FVXDIUWLPYTCGR-UHFFFAOYSA-N	373165	US9896452, Example 25::rac-(2-((benzo[d]oxazol-2-ylamino)methyl)-6-methylpiperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone	Orexin receptor type 2	Homo sapiens		 130							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373165	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373165&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			77914734	404342267							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740861	CC1CCCC(CNc2ccc(cn2)C(F)(F)F)N1C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C24H24F4N4OS/c1-14-4-3-5-19(13-30-20-11-8-17(12-29-20)24(26,27)28)32(14)23(33)21-22(34-15(2)31-21)16-6-9-18(25)10-7-16/h6-12,14,19H,3-5,13H2,1-2H3,(H,29,30)	SBWIUDUFVJTASW-UHFFFAOYSA-N	373166	US9896452, Example 26::rac-(5-(4-fluorophenyl)-2-methylthiazol-4-yl)(2-methyl-6-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)methanone	Orexin/Hypocretin receptor type 1	Homo sapiens		 18.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373166	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373166&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			77910111	404342268							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740862	CC1CCCC(CNc2ccc(cn2)C(F)(F)F)N1C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C24H24F4N4OS/c1-14-4-3-5-19(13-30-20-11-8-17(12-29-20)24(26,27)28)32(14)23(33)21-22(34-15(2)31-21)16-6-9-18(25)10-7-16/h6-12,14,19H,3-5,13H2,1-2H3,(H,29,30)	SBWIUDUFVJTASW-UHFFFAOYSA-N	373166	US9896452, Example 26::rac-(5-(4-fluorophenyl)-2-methylthiazol-4-yl)(2-methyl-6-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)methanone	Orexin receptor type 2	Homo sapiens		 91.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373166	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373166&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			77910111	404342268							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740863	CC1CCCC(CNc2ncc(cn2)C(F)(F)F)N1C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C23H23F4N5OS/c1-13-4-3-5-18(12-30-22-28-10-16(11-29-22)23(25,26)27)32(13)21(33)19-20(34-14(2)31-19)15-6-8-17(24)9-7-15/h6-11,13,18H,3-5,12H2,1-2H3,(H,28,29,30)	AQUMLOZSCYYXEA-UHFFFAOYSA-N	373167	US9896452, Example 27::rac-(5-(4-fluorophenyl)-2-methylthiazol-4-yl)(2-methyl-6-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidin-1-yl)methanone	Orexin/Hypocretin receptor type 1	Homo sapiens		<100.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373167	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373167&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89748143	404342269							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740864	CC1CCCC(CNc2ncc(Cl)cn2)N1C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C22H23ClFN5OS/c1-13-4-3-5-18(12-27-22-25-10-16(23)11-26-22)29(13)21(30)19-20(31-14(2)28-19)15-6-8-17(24)9-7-15/h6-11,13,18H,3-5,12H2,1-2H3,(H,25,26,27)	IAZXUHGMBKWBCV-UHFFFAOYSA-N	373168	US9896452, Example 28::rac-(2-(((5-chloropyrimidin-2-yl)amino)methyl)-6-methylpiperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone	Orexin/Hypocretin receptor type 1	Homo sapiens		<10.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373168	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373168&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89739795	404342270							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740865	CC1CCCC(CNC(=O)c2cccc3cccnc23)N1C(=O)c1sc(C)nc1-c1ccccc1	InChI=1S/C28H28N4O2S/c1-18-9-6-14-22(17-30-27(33)23-15-7-12-20-13-8-16-29-24(20)23)32(18)28(34)26-25(31-19(2)35-26)21-10-4-3-5-11-21/h3-5,7-8,10-13,15-16,18,22H,6,9,14,17H2,1-2H3,(H,30,33)	UYFSZMFVAPDOIB-UHFFFAOYSA-N	373169	US9896452, Example 29::rac-N-((6-Methyl-1-(2-methyl-4-phenylthiazole-5-carbonyl)piperidin-2-yl)methyl)quinoline-8-carboxamide	Orexin/Hypocretin receptor type 1	Homo sapiens		 200							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373169	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373169&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89739887	404342271							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740866	CC1CCCC(CCOc2ccccc2)N1C(=O)c1sc(C)nc1-c1ccccc1	InChI=1S/C25H28N2O2S/c1-18-10-9-13-21(16-17-29-22-14-7-4-8-15-22)27(18)25(28)24-23(26-19(2)30-24)20-11-5-3-6-12-20/h3-8,11-12,14-15,18,21H,9-10,13,16-17H2,1-2H3	FHRILBYWZIGJNT-UHFFFAOYSA-N	373170	US9896452, Example 30::rac-(2-Methyl-4-phenylthiazol-5-yl)(2-methyl-6-(2-phenoxyethyl)piperidin-1-yl)methanone	Orexin/Hypocretin receptor type 1	Homo sapiens		 220							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373170	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373170&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89739624	404342272							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740867	CC1CCCC(CCOc2ccccc2)N1C(=O)c1ccccc1-c1ccccc1	InChI=1S/C27H29NO2/c1-21-11-10-14-23(19-20-30-24-15-6-3-7-16-24)28(21)27(29)26-18-9-8-17-25(26)22-12-4-2-5-13-22/h2-9,12-13,15-18,21,23H,10-11,14,19-20H2,1H3	WACHPVVURZYHCE-UHFFFAOYSA-N	373171	US9896452, Example 31::rac-Biphenyl-2-yl(2-methyl-6-(2-phenoxyethyl)piperidin-1-yl)methanone	Orexin/Hypocretin receptor type 1	Homo sapiens		 10.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373171	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373171&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			71715161	404342273							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740868	OC1CCC(CNC(=O)c2cccc3cccnc23)N(C1)C(=O)c1ccccc1-c1ccccc1	InChI=1S/C29H27N3O3/c33-23-16-15-22(18-31-28(34)26-14-6-10-21-11-7-17-30-27(21)26)32(19-23)29(35)25-13-5-4-12-24(25)20-8-2-1-3-9-20/h1-14,17,22-23,33H,15-16,18-19H2,(H,31,34)	HLZFNXPRACQSDC-UHFFFAOYSA-N	373172	US9896452, Example 32::rac-N-((1-(biphenylcarbonyl)-5-hydroxypiperidin-2-yl)methyl)quinoline-8-carboxamide	Orexin/Hypocretin receptor type 1	Homo sapiens		 2.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373172	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373172&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			77912472	404342274							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740869	OC1CCC(CNC(=O)c2cccc3cccnc23)N(C1)C(=O)c1ccccc1-c1ccccc1	InChI=1S/C29H27N3O3/c33-23-16-15-22(18-31-28(34)26-14-6-10-21-11-7-17-30-27(21)26)32(19-23)29(35)25-13-5-4-12-24(25)20-8-2-1-3-9-20/h1-14,17,22-23,33H,15-16,18-19H2,(H,31,34)	HLZFNXPRACQSDC-UHFFFAOYSA-N	373172	US9896452, Example 32::rac-N-((1-(biphenylcarbonyl)-5-hydroxypiperidin-2-yl)methyl)quinoline-8-carboxamide	Orexin receptor type 2	Homo sapiens		 14.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373172	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373172&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			77912472	404342274							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740870	Cc1nc(c(s1)C(=O)N1CC(O)CCC1CNC(=O)c1cccc2cccnc12)-c1ccccc1	InChI=1S/C27H26N4O3S/c1-17-30-24(19-7-3-2-4-8-19)25(35-17)27(34)31-16-21(32)13-12-20(31)15-29-26(33)22-11-5-9-18-10-6-14-28-23(18)22/h2-11,14,20-21,32H,12-13,15-16H2,1H3,(H,29,33)	IFRXSCTYHQVBNC-UHFFFAOYSA-N	373173	US9896452, Example 33::rac-N-((5-hydroxy-1-(2-methyl-4-phenylthiazole-5-carbonyl)piperidin-2-yl)methyl)quinoline-8-carboxamide	Orexin/Hypocretin receptor type 1	Homo sapiens		 20.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373173	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373173&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			71715162	404342275							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740871	Cc1nc(c(s1)C(=O)N1CC(F)(F)CCC1CNC(=O)c1cccc2cccnc12)-c1ccccc1	InChI=1S/C27H24F2N4O2S/c1-17-32-23(19-7-3-2-4-8-19)24(36-17)26(35)33-16-27(28,29)13-12-20(33)15-31-25(34)21-11-5-9-18-10-6-14-30-22(18)21/h2-11,14,20H,12-13,15-16H2,1H3,(H,31,34)	KQXAPLULDRCBLD-UHFFFAOYSA-N	373174	US9896452, Example 34::rac-N-((5,5-difluoro-1-(2-methyl-4-phenylthiazole-5-carbonyl)piperidin-2-yl)methyl)quinoline-8-carboxamide	Orexin/Hypocretin receptor type 1	Homo sapiens		 5.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373174	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373174&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			71715219	404342276							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740872	Cc1nc(c(s1)C(=O)N1CC(F)(F)CCC1CNC(=O)c1cccc2cccnc12)-c1ccccc1	InChI=1S/C27H24F2N4O2S/c1-17-32-23(19-7-3-2-4-8-19)24(36-17)26(35)33-16-27(28,29)13-12-20(33)15-31-25(34)21-11-5-9-18-10-6-14-30-22(18)21/h2-11,14,20H,12-13,15-16H2,1H3,(H,31,34)	KQXAPLULDRCBLD-UHFFFAOYSA-N	373174	US9896452, Example 34::rac-N-((5,5-difluoro-1-(2-methyl-4-phenylthiazole-5-carbonyl)piperidin-2-yl)methyl)quinoline-8-carboxamide	Orexin receptor type 2	Homo sapiens		 5.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373174	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373174&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			71715219	404342276							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740873	Cc1nc(c(s1)C(=O)N1CC(F)CCC1CNC(=O)c1cccc2cccnc12)-c1ccccc1	InChI=1S/C27H25FN4O2S/c1-17-31-24(19-7-3-2-4-8-19)25(35-17)27(34)32-16-20(28)12-13-21(32)15-30-26(33)22-11-5-9-18-10-6-14-29-23(18)22/h2-11,14,20-21H,12-13,15-16H2,1H3,(H,30,33)	PDMLXAVPZLMYSF-UHFFFAOYSA-N	373175	US9896452, Example 35::rac-N-((5-fluoro-1-(2-methyl-4-phenylthiazole-5-carbonyl)piperidin-2-yl)methyl)quinoline-8-carboxamide	Orexin/Hypocretin receptor type 1	Homo sapiens		 2.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373175	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373175&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			71715220	404342277							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740874	Cc1nc(c(s1)C(=O)N1CC(F)CCC1CNC(=O)c1cccc2cccnc12)-c1ccccc1	InChI=1S/C27H25FN4O2S/c1-17-31-24(19-7-3-2-4-8-19)25(35-17)27(34)32-16-20(28)12-13-21(32)15-30-26(33)22-11-5-9-18-10-6-14-29-23(18)22/h2-11,14,20-21H,12-13,15-16H2,1H3,(H,30,33)	PDMLXAVPZLMYSF-UHFFFAOYSA-N	373175	US9896452, Example 35::rac-N-((5-fluoro-1-(2-methyl-4-phenylthiazole-5-carbonyl)piperidin-2-yl)methyl)quinoline-8-carboxamide	Orexin receptor type 2	Homo sapiens		 4.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373175	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373175&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			71715220	404342277							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740875	FC1(F)CCC(CNC(=O)c2cccc3cccnc23)N(C1)C(=O)c1ccccc1-c1ccccc1	InChI=1S/C29H25F2N3O2/c30-29(31)16-15-22(18-33-27(35)25-14-6-10-21-11-7-17-32-26(21)25)34(19-29)28(36)24-13-5-4-12-23(24)20-8-2-1-3-9-20/h1-14,17,22H,15-16,18-19H2,(H,33,35)	VGFZJFYRKGSKGE-UHFFFAOYSA-N	373176	US9896452, Example 36::rac-N-((1-(biphenylcarbonyl)-5,5-difluoropiperidin-2-yl)methyl)quinoline-8-carboxamide	Orexin/Hypocretin receptor type 1	Homo sapiens		 2.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373176	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373176&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			71715221	404342278							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740876	FC1(F)CCC(CNC(=O)c2cccc3cccnc23)N(C1)C(=O)c1ccccc1-c1ccccc1	InChI=1S/C29H25F2N3O2/c30-29(31)16-15-22(18-33-27(35)25-14-6-10-21-11-7-17-32-26(21)25)34(19-29)28(36)24-13-5-4-12-23(24)20-8-2-1-3-9-20/h1-14,17,22H,15-16,18-19H2,(H,33,35)	VGFZJFYRKGSKGE-UHFFFAOYSA-N	373176	US9896452, Example 36::rac-N-((1-(biphenylcarbonyl)-5,5-difluoropiperidin-2-yl)methyl)quinoline-8-carboxamide	Orexin receptor type 2	Homo sapiens		 2.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373176	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373176&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			71715221	404342278							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740877	F[C@H]1CCC(CNC(=O)c2cccc3cccnc23)N(C1)C(=O)c1ccccc1-c1ccccc1	InChI=1S/C29H26FN3O2/c30-22-15-16-23(18-32-28(34)26-14-6-10-21-11-7-17-31-27(21)26)33(19-22)29(35)25-13-5-4-12-24(25)20-8-2-1-3-9-20/h1-14,17,22-23H,15-16,18-19H2,(H,32,34)/t22-,23?/m0/s1	SVWRBCQUGLPUCX-NQCNTLBGSA-N	373177	US9896452, Example 37::rac-N-(((5S)-1-(biphenylcarbonyl)-5-fluoropiperidin-2-yl)methyl)quinoline-8-carboxamide	Orexin/Hypocretin receptor type 1	Homo sapiens		 1.000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373177	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373177&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			71661445	404342279							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740878	F[C@H]1CCC(CNC(=O)c2cccc3cccnc23)N(C1)C(=O)c1ccccc1-c1ccccc1	InChI=1S/C29H26FN3O2/c30-22-15-16-23(18-32-28(34)26-14-6-10-21-11-7-17-31-27(21)26)33(19-22)29(35)25-13-5-4-12-24(25)20-8-2-1-3-9-20/h1-14,17,22-23H,15-16,18-19H2,(H,32,34)/t22-,23?/m0/s1	SVWRBCQUGLPUCX-NQCNTLBGSA-N	373177	US9896452, Example 37::rac-N-(((5S)-1-(biphenylcarbonyl)-5-fluoropiperidin-2-yl)methyl)quinoline-8-carboxamide	Orexin receptor type 2	Homo sapiens		 3.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373177	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373177&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			71661445	404342279							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740879	F[C@@H]1CCC(CNC(=O)c2cccc3cccnc23)N(C1)C(=O)c1ccccc1-c1ccccc1	InChI=1S/C29H26FN3O2/c30-22-15-16-23(18-32-28(34)26-14-6-10-21-11-7-17-31-27(21)26)33(19-22)29(35)25-13-5-4-12-24(25)20-8-2-1-3-9-20/h1-14,17,22-23H,15-16,18-19H2,(H,32,34)/t22-,23?/m1/s1	SVWRBCQUGLPUCX-WTQRLHSKSA-N	373178	US9896452, Example 38::rac-N-(((5R)-1-(biphenylcarbonyl)-5-fluoropiperidin-2-yl)methyl)quinoline-8-carboxamide	Orexin/Hypocretin receptor type 1	Homo sapiens		 4.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373178	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373178&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89748158	404342280							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740880	NC1CCC(CNC(=O)c2cccc3cccnc23)N(C1)C(=O)c1ccccc1-c1ccccc1	InChI=1S/C29H28N4O2/c30-22-15-16-23(18-32-28(34)26-14-6-10-21-11-7-17-31-27(21)26)33(19-22)29(35)25-13-5-4-12-24(25)20-8-2-1-3-9-20/h1-14,17,22-23H,15-16,18-19,30H2,(H,32,34)	PPHZKHDCSGWDSH-UHFFFAOYSA-N	373179	US9896452, Example 39::rac-N-((5-amino-1-(biphenylcarbonyl)piperidin-2-yl)methyl)quinoline-8-carboxamide	Orexin/Hypocretin receptor type 1	Homo sapiens		 30.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373179	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373179&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			71715222	404342281							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740881	NC1CCC(CNC(=O)c2cccc3cccnc23)N(C1)C(=O)c1ccccc1-c1ccccc1	InChI=1S/C29H28N4O2/c30-22-15-16-23(18-32-28(34)26-14-6-10-21-11-7-17-31-27(21)26)33(19-22)29(35)25-13-5-4-12-24(25)20-8-2-1-3-9-20/h1-14,17,22-23H,15-16,18-19,30H2,(H,32,34)	PPHZKHDCSGWDSH-UHFFFAOYSA-N	373179	US9896452, Example 39::rac-N-((5-amino-1-(biphenylcarbonyl)piperidin-2-yl)methyl)quinoline-8-carboxamide	Orexin receptor type 2	Homo sapiens		 160							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373179	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373179&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			71715222	404342281							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740882	O=C(NCC1CCC(CN1C(=O)c1ccccc1-c1ccccc1)NCc1ccccc1)c1cccc2cccnc12	InChI=1S/C36H34N4O2/c41-35(33-19-9-15-28-16-10-22-37-34(28)33)39-24-30-21-20-29(38-23-26-11-3-1-4-12-26)25-40(30)36(42)32-18-8-7-17-31(32)27-13-5-2-6-14-27/h1-19,22,29-30,38H,20-21,23-25H2,(H,39,41)	PHOJWFIUZALYEW-UHFFFAOYSA-N	373180	US9896452, Example 40::rac-N-((5-(benzylamino)-1-(biphenylcarbonyl)piperidin-2-yl)methyl)quinoline-8-carboxamide	Orexin/Hypocretin receptor type 1	Homo sapiens		 600							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373180	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373180&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			71715223	404342282							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740883	O=C(NCC1CCC(CN1C(=O)c1ccccc1-c1ccccc1)NCc1ccccc1)c1cccc2cccnc12	InChI=1S/C36H34N4O2/c41-35(33-19-9-15-28-16-10-22-37-34(28)33)39-24-30-21-20-29(38-23-26-11-3-1-4-12-26)25-40(30)36(42)32-18-8-7-17-31(32)27-13-5-2-6-14-27/h1-19,22,29-30,38H,20-21,23-25H2,(H,39,41)	PHOJWFIUZALYEW-UHFFFAOYSA-N	373180	US9896452, Example 40::rac-N-((5-(benzylamino)-1-(biphenylcarbonyl)piperidin-2-yl)methyl)quinoline-8-carboxamide	Orexin receptor type 2	Homo sapiens		 1500							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373180	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373180&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			71715223	404342282							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740884	CN(C)C1CCC(CNC(=O)c2cccc3cccnc23)N(C1)C(=O)c1ccccc1-c1ccccc1	InChI=1S/C31H32N4O2/c1-34(2)25-18-17-24(20-33-30(36)28-16-8-12-23-13-9-19-32-29(23)28)35(21-25)31(37)27-15-7-6-14-26(27)22-10-4-3-5-11-22/h3-16,19,24-25H,17-18,20-21H2,1-2H3,(H,33,36)	PQHANPYFHWQTGR-UHFFFAOYSA-N	373181	US9896452, Example 41::rac-N-((1-(biphenylcarbonyl)-5-(dimethylamino)piperidin-2-yl)methyl)quinoline-8-carboxamide	Orexin/Hypocretin receptor type 1	Homo sapiens		 1500							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373181	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373181&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			71715275	404342283							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740885	OCCNC1CCC(CNC(=O)c2cccc3cccnc23)N(C1)C(=O)c1ccccc1-c1ccccc1	InChI=1S/C31H32N4O3/c36-19-18-32-24-15-16-25(20-34-30(37)28-14-6-10-23-11-7-17-33-29(23)28)35(21-24)31(38)27-13-5-4-12-26(27)22-8-2-1-3-9-22/h1-14,17,24-25,32,36H,15-16,18-21H2,(H,34,37)	QXOYXBXFMZTJDV-UHFFFAOYSA-N	373182	US9896452, Example 42::rac-N-((1-(biphenylcarbonyl)-5-(2-hydroxyethylamino)piperidin-2-yl)methyl)quinoline-8-carboxamide	Orexin/Hypocretin receptor type 1	Homo sapiens		 27.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373182	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373182&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			71715276	404342284							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740886	OCCNC1CCC(CNC(=O)c2cccc3cccnc23)N(C1)C(=O)c1ccccc1-c1ccccc1	InChI=1S/C31H32N4O3/c36-19-18-32-24-15-16-25(20-34-30(37)28-14-6-10-23-11-7-17-33-29(23)28)35(21-24)31(38)27-13-5-4-12-26(27)22-8-2-1-3-9-22/h1-14,17,24-25,32,36H,15-16,18-21H2,(H,34,37)	QXOYXBXFMZTJDV-UHFFFAOYSA-N	373182	US9896452, Example 42::rac-N-((1-(biphenylcarbonyl)-5-(2-hydroxyethylamino)piperidin-2-yl)methyl)quinoline-8-carboxamide	Orexin receptor type 2	Homo sapiens		 140							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373182	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373182&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			71715276	404342284							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740887	CC(=O)NC1CCC(CNC(=O)c2cccc3cccnc23)N(C1)C(=O)c1ccccc1-c1ccccc1	InChI=1S/C31H30N4O3/c1-21(36)34-24-16-17-25(19-33-30(37)28-15-7-11-23-12-8-18-32-29(23)28)35(20-24)31(38)27-14-6-5-13-26(27)22-9-3-2-4-10-22/h2-15,18,24-25H,16-17,19-20H2,1H3,(H,33,37)(H,34,36)	MZMLMHWAGQHUOH-UHFFFAOYSA-N	373183	US9896452, Example 43::rac-N-((5-acetamido-1-(biphenylcarbonyl)piperidin-2-yl)methyl)quinoline-8-carboxamide	Orexin/Hypocretin receptor type 1	Homo sapiens		 2000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373183	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373183&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			71715277	404342285							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740888	Cc1nc(c(s1)C(=O)N1CC(N)CCC1CNC(=O)c1cccc2cccnc12)-c1ccccc1	InChI=1S/C27H27N5O2S/c1-17-31-24(19-7-3-2-4-8-19)25(35-17)27(34)32-16-20(28)12-13-21(32)15-30-26(33)22-11-5-9-18-10-6-14-29-23(18)22/h2-11,14,20-21H,12-13,15-16,28H2,1H3,(H,30,33)	WGLJHTQZRNCVHT-UHFFFAOYSA-N	373184	US9896452, Example 44::rac-N-((5-amino-1-(2-methyl-4-phenylthiazole-5-carbonyl)piperidin-2-yl)methyl)quinoline-8-carboxamide	Orexin receptor type 2	Homo sapiens		 1000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373184	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373184&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			71715278	404342286							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740889	CNC1CCC(CNC(=O)c2cccc3cccnc23)N(C1)C(=O)c1sc(C)nc1-c1ccccc1	InChI=1S/C28H29N5O2S/c1-18-32-25(20-8-4-3-5-9-20)26(36-18)28(35)33-17-21(29-2)13-14-22(33)16-31-27(34)23-12-6-10-19-11-7-15-30-24(19)23/h3-12,15,21-22,29H,13-14,16-17H2,1-2H3,(H,31,34)	GOHRGUIYECZJKC-UHFFFAOYSA-N	373185	US9896452, Example 45::rac-N-((1-(2-methyl-4-phenylthiazole-5-carbonyl)-5-(methylamino)piperidin-2-yl)methyl)quinoline-8-carboxamide	Orexin/Hypocretin receptor type 1	Homo sapiens		<10000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373185	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373185&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			71715279	404342287							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740890	CCNC1CCC(CNC(=O)c2cccc3cccnc23)N(C1)C(=O)c1sc(C)nc1-c1ccccc1	InChI=1S/C29H31N5O2S/c1-3-30-22-14-15-23(17-32-28(35)24-13-7-11-20-12-8-16-31-25(20)24)34(18-22)29(36)27-26(33-19(2)37-27)21-9-5-4-6-10-21/h4-13,16,22-23,30H,3,14-15,17-18H2,1-2H3,(H,32,35)	QDQCKQVWPRJCQY-UHFFFAOYSA-N	373186	US9896452, Example 46::rac-N-((5-(ethylamino)-1-(2-methyl-4-phenylthiazole-5-carbonyl)piperidin-2-yl)methyl)quinoline-8-carboxamide	Orexin/Hypocretin receptor type 1	Homo sapiens		<10000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373186	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373186&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89739541	404342288							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740891	Cc1nc(c(s1)C(=O)N1CC(CCC1CNC(=O)c1cccc2cccnc12)NCCO)-c1ccccc1	InChI=1S/C29H31N5O3S/c1-19-33-26(21-7-3-2-4-8-21)27(38-19)29(37)34-18-22(30-15-16-35)12-13-23(34)17-32-28(36)24-11-5-9-20-10-6-14-31-25(20)24/h2-11,14,22-23,30,35H,12-13,15-18H2,1H3,(H,32,36)	AXRHGYITDQXUJP-UHFFFAOYSA-N	373187	US9896452, Example 47::rac-N-((5-(2-hydroxyethylamino)-1-(2-methyl-4-phenylthiazole-5-carbonyl)piperidin-2-yl)methyl)quinoline-8-carboxamide	Orexin/Hypocretin receptor type 1	Homo sapiens		<10000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373187	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373187&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			71715331	404342289							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740892	CC(C)NC1CCC(CNC(=O)c2cccc3cccnc23)N(C1)C(=O)c1ccccc1-c1ccccc1	InChI=1S/C32H34N4O2/c1-22(2)35-25-17-18-26(20-34-31(37)29-16-8-12-24-13-9-19-33-30(24)29)36(21-25)32(38)28-15-7-6-14-27(28)23-10-4-3-5-11-23/h3-16,19,22,25-26,35H,17-18,20-21H2,1-2H3,(H,34,37)	FATYCOZXMMXKQG-UHFFFAOYSA-N	373188	US9896452, Example 48::rac-N-((5-(isopropylamino)-1-(2-methyl-4-phenylthiazole-5-carbonyl)piperidin-2-yl)methyl)quinoline-8-carboxamide	Orexin/Hypocretin receptor type 1	Homo sapiens		<10000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373188	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373188&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			71715332	404342290							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740893	CNC1CCC(CNC(=O)c2cccc3cccnc23)N(C1)C(=O)c1ccccc1-c1ccccc1	InChI=1S/C30H30N4O2/c1-31-23-16-17-24(19-33-29(35)27-15-7-11-22-12-8-18-32-28(22)27)34(20-23)30(36)26-14-6-5-13-25(26)21-9-3-2-4-10-21/h2-15,18,23-24,31H,16-17,19-20H2,1H3,(H,33,35)	SILMITZNSAZHEU-UHFFFAOYSA-N	373189	US9896452, Example 49::rac-N-((1-(biphenylcarbonyl)-5-(methylamino)piperidin-2-yl)methyl)quinoline-8-carboxamide	Orexin/Hypocretin receptor type 1	Homo sapiens		 25.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373189	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373189&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			71715333	404342291							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740894	CNC1CCC(CNC(=O)c2cccc3cccnc23)N(C1)C(=O)c1ccccc1-c1ccccc1	InChI=1S/C30H30N4O2/c1-31-23-16-17-24(19-33-29(35)27-15-7-11-22-12-8-18-32-28(22)27)34(20-23)30(36)26-14-6-5-13-25(26)21-9-3-2-4-10-21/h2-15,18,23-24,31H,16-17,19-20H2,1H3,(H,33,35)	SILMITZNSAZHEU-UHFFFAOYSA-N	373189	US9896452, Example 49::rac-N-((1-(biphenylcarbonyl)-5-(methylamino)piperidin-2-yl)methyl)quinoline-8-carboxamide	Orexin receptor type 2	Homo sapiens		 600							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373189	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373189&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			71715333	404342291							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740895	COC1CCC(CNC(=O)c2cccc3cccnc23)N(C1)C(=O)c1nc(C)sc1-c1cccc(F)c1	InChI=1S/C28H27FN4O3S/c1-17-32-25(26(37-17)19-7-3-9-20(29)14-19)28(35)33-16-22(36-2)12-11-21(33)15-31-27(34)23-10-4-6-18-8-5-13-30-24(18)23/h3-10,13-14,21-22H,11-12,15-16H2,1-2H3,(H,31,34)	AJTIMWIUTAUCNS-UHFFFAOYSA-N	373190	US9896452, Example 50::rac-N-((1-(5-(3-fluorophenyl)-2-methylthiazole-4-carbonyl)-5-methoxypiperidin-2-yl)methyl)quinoline-8-carboxamide	Orexin/Hypocretin receptor type 1	Homo sapiens		 7.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373190	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373190&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			71715334	404342292							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740896	COC1CCC(CNC(=O)c2cccc3cccnc23)N(C1)C(=O)c1nc(C)sc1-c1cccc(F)c1	InChI=1S/C28H27FN4O3S/c1-17-32-25(26(37-17)19-7-3-9-20(29)14-19)28(35)33-16-22(36-2)12-11-21(33)15-31-27(34)23-10-4-6-18-8-5-13-30-24(18)23/h3-10,13-14,21-22H,11-12,15-16H2,1-2H3,(H,31,34)	AJTIMWIUTAUCNS-UHFFFAOYSA-N	373190	US9896452, Example 50::rac-N-((1-(5-(3-fluorophenyl)-2-methylthiazole-4-carbonyl)-5-methoxypiperidin-2-yl)methyl)quinoline-8-carboxamide	Orexin receptor type 2	Homo sapiens		 25.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373190	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373190&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			71715334	404342292							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740897	Cc1nc(C(=O)N2CC(O)CCC2CNC(=O)c2cccc3cccnc23)c(s1)-c1cccc(F)c1	InChI=1S/C27H25FN4O3S/c1-16-31-24(25(36-16)18-6-2-8-19(28)13-18)27(35)32-15-21(33)11-10-20(32)14-30-26(34)22-9-3-5-17-7-4-12-29-23(17)22/h2-9,12-13,20-21,33H,10-11,14-15H2,1H3,(H,30,34)	LPVNPTPPUWEVKR-UHFFFAOYSA-N	373191	US9896452, Example 51::rac-N-((1-(5-(3-fluorophenyl)-2-methylthiazole-4-carbonyl)-5-hydroxypiperidin-2-yl)methyl)quinoline-8-carboxamide	Orexin/Hypocretin receptor type 1	Homo sapiens		 10.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373191	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373191&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			71715335	404342293							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740898	Cc1nc(C(=O)N2CC(O)CCC2CNC(=O)c2cccc3cccnc23)c(s1)-c1cccc(F)c1	InChI=1S/C27H25FN4O3S/c1-16-31-24(25(36-16)18-6-2-8-19(28)13-18)27(35)32-15-21(33)11-10-20(32)14-30-26(34)22-9-3-5-17-7-4-12-29-23(17)22/h2-9,12-13,20-21,33H,10-11,14-15H2,1H3,(H,30,34)	LPVNPTPPUWEVKR-UHFFFAOYSA-N	373191	US9896452, Example 51::rac-N-((1-(5-(3-fluorophenyl)-2-methylthiazole-4-carbonyl)-5-hydroxypiperidin-2-yl)methyl)quinoline-8-carboxamide	Orexin receptor type 2	Homo sapiens		 75.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373191	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373191&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			71715335	404342293							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740899	Cc1nc(C(=O)N2CC(F)(F)CCC2CNC(=O)c2cccc3cccnc23)c(s1)-c1cccc(F)c1	InChI=1S/C27H23F3N4O2S/c1-16-33-23(24(37-16)18-6-2-8-19(28)13-18)26(36)34-15-27(29,30)11-10-20(34)14-32-25(35)21-9-3-5-17-7-4-12-31-22(17)21/h2-9,12-13,20H,10-11,14-15H2,1H3,(H,32,35)	YCPDCUAUNGQDQS-UHFFFAOYSA-N	373192	US9896452, Example 52::rac-N-((5,5-difluoro-1-(5-(3-fluorophenyl)-2-methylthiazole-4-carbonyl)piperidin-2-yl)methyl)quinoline-8-carboxamide	Orexin/Hypocretin receptor type 1	Homo sapiens		 1.000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373192	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373192&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89739846	404342294							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740900	Cc1nc(C(=O)N2CC(F)(F)CCC2CNC(=O)c2cccc3cccnc23)c(s1)-c1cccc(F)c1	InChI=1S/C27H23F3N4O2S/c1-16-33-23(24(37-16)18-6-2-8-19(28)13-18)26(36)34-15-27(29,30)11-10-20(34)14-32-25(35)21-9-3-5-17-7-4-12-31-22(17)21/h2-9,12-13,20H,10-11,14-15H2,1H3,(H,32,35)	YCPDCUAUNGQDQS-UHFFFAOYSA-N	373192	US9896452, Example 52::rac-N-((5,5-difluoro-1-(5-(3-fluorophenyl)-2-methylthiazole-4-carbonyl)piperidin-2-yl)methyl)quinoline-8-carboxamide	Orexin receptor type 2	Homo sapiens		 10.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373192	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373192&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			89739846	404342294							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740901	Cc1nc(C(=O)N2CC(N)CCC2CNC(=O)c2cccc3cccnc23)c(s1)-c1cccc(F)c1	InChI=1S/C27H26FN5O2S/c1-16-32-24(25(36-16)18-6-2-8-19(28)13-18)27(35)33-15-20(29)10-11-21(33)14-31-26(34)22-9-3-5-17-7-4-12-30-23(17)22/h2-9,12-13,20-21H,10-11,14-15,29H2,1H3,(H,31,34)	DGIIYCMWCFSJQG-UHFFFAOYSA-N	373193	US9896452, Example 53::rac-N-((5-amino-1-(5-(3-fluorophenyl)-2-methylthiazole-4-carbonyl)piperidin-2-yl)methyl)quinoline-8-carboxamide	Orexin/Hypocretin receptor type 1	Homo sapiens		 65.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373193	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373193&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89739505	404342295							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740902	Cc1nc(C(=O)N2CC(N)CCC2CNC(=O)c2cccc3cccnc23)c(s1)-c1cccc(F)c1	InChI=1S/C27H26FN5O2S/c1-16-32-24(25(36-16)18-6-2-8-19(28)13-18)27(35)33-15-20(29)10-11-21(33)14-31-26(34)22-9-3-5-17-7-4-12-30-23(17)22/h2-9,12-13,20-21H,10-11,14-15,29H2,1H3,(H,31,34)	DGIIYCMWCFSJQG-UHFFFAOYSA-N	373193	US9896452, Example 53::rac-N-((5-amino-1-(5-(3-fluorophenyl)-2-methylthiazole-4-carbonyl)piperidin-2-yl)methyl)quinoline-8-carboxamide	Orexin receptor type 2	Homo sapiens		 750							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373193	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373193&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			89739505	404342295							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740903	Cc1nc(C(=O)N2CC(CCC2CNC(=O)c2cccc3cccnc23)NCCO)c(s1)-c1cccc(F)c1	InChI=1S/C29H30FN5O3S/c1-18-34-26(27(39-18)20-6-2-8-21(30)15-20)29(38)35-17-22(31-13-14-36)10-11-23(35)16-33-28(37)24-9-3-5-19-7-4-12-32-25(19)24/h2-9,12,15,22-23,31,36H,10-11,13-14,16-17H2,1H3,(H,33,37)	UDAXLZISFGUGMW-UHFFFAOYSA-N	373194	US9896452, Example 54::rac-N-((1-(5-(3-fluorophenyl)-2-methylthiazole-4-carbonyl)-5-(2-hydroxyethylamino)piperidin-2-yl)methyl)quinoline-8-carboxamide	Orexin/Hypocretin receptor type 1	Homo sapiens		 180							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373194	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373194&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			71715389	404342296							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740904	Cc1nc(C(=O)N2CC(CCC2CNC(=O)c2cccc3cccnc23)NCCO)c(s1)-c1cccc(F)c1	InChI=1S/C29H30FN5O3S/c1-18-34-26(27(39-18)20-6-2-8-21(30)15-20)29(38)35-17-22(31-13-14-36)10-11-23(35)16-33-28(37)24-9-3-5-19-7-4-12-32-25(19)24/h2-9,12,15,22-23,31,36H,10-11,13-14,16-17H2,1H3,(H,33,37)	UDAXLZISFGUGMW-UHFFFAOYSA-N	373194	US9896452, Example 54::rac-N-((1-(5-(3-fluorophenyl)-2-methylthiazole-4-carbonyl)-5-(2-hydroxyethylamino)piperidin-2-yl)methyl)quinoline-8-carboxamide	Orexin receptor type 2	Homo sapiens		 1200							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373194	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373194&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			71715389	404342296							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740905	Cc1nc(C(=O)N2CC(N)CCC2CNC(=O)c2cccc3cccnc23)c(s1)-c1ccccc1	InChI=1S/C27H27N5O2S/c1-17-31-24(25(35-17)19-7-3-2-4-8-19)27(34)32-16-20(28)12-13-21(32)15-30-26(33)22-11-5-9-18-10-6-14-29-23(18)22/h2-11,14,20-21H,12-13,15-16,28H2,1H3,(H,30,33)	CMEYWYAGTUKFKO-UHFFFAOYSA-N	373195	US9896452, Example 55::rac-N-((5-amino-1-(2-methyl-5-phenylthiazole-4-carbonyl)piperidin-2-yl)methyl)quinoline-8-carboxamide	Orexin/Hypocretin receptor type 1	Homo sapiens		 120							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373195	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373195&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			71715390	404342297							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740906	Cc1nc(C(=O)N2CC(N)CCC2CNC(=O)c2cccc3cccnc23)c(s1)-c1ccccc1	InChI=1S/C27H27N5O2S/c1-17-31-24(25(35-17)19-7-3-2-4-8-19)27(34)32-16-20(28)12-13-21(32)15-30-26(33)22-11-5-9-18-10-6-14-29-23(18)22/h2-11,14,20-21H,12-13,15-16,28H2,1H3,(H,30,33)	CMEYWYAGTUKFKO-UHFFFAOYSA-N	373195	US9896452, Example 55::rac-N-((5-amino-1-(2-methyl-5-phenylthiazole-4-carbonyl)piperidin-2-yl)methyl)quinoline-8-carboxamide	Orexin receptor type 2	Homo sapiens		 2000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373195	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373195&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			71715390	404342297							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740907	Cc1nc(C(=O)N2CC(F)(F)CCC2CNC(=O)c2cccc3cccnc23)c(s1)-c1ccccc1	InChI=1S/C27H24F2N4O2S/c1-17-32-23(24(36-17)19-7-3-2-4-8-19)26(35)33-16-27(28,29)13-12-20(33)15-31-25(34)21-11-5-9-18-10-6-14-30-22(18)21/h2-11,14,20H,12-13,15-16H2,1H3,(H,31,34)	DDOYCBFXVKQWOL-UHFFFAOYSA-N	373196	US9896452, Example 56::rac-N-((5,5-difluoro-1-(2-methyl-5-phenylthiazole-4-carbonyl)piperidin-2-yl)methyl)quinoline-8-carboxamide	Orexin/Hypocretin receptor type 1	Homo sapiens		<100.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373196	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373196&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			71715391	404342298							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740908	Cc1cc2c(cccc2o1)C(=O)NCC1CCC(F)(F)CN1C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C27H24F3N3O3S/c1-15-12-21-20(4-3-5-22(21)36-15)25(34)31-13-19-10-11-27(29,30)14-33(19)26(35)23-24(37-16(2)32-23)17-6-8-18(28)9-7-17/h3-9,12,19H,10-11,13-14H2,1-2H3,(H,31,34)	VEPJQJFBXDGTGY-UHFFFAOYSA-N	373197	US9896452, Example 57::rac-N-((5,5-difluoro-1-(5-(4-fluorophenyl)-2-methylthiazole-4-carbonyl)piperidin-2-yl)methyl)-2-methylbenzofuran-4-carboxamide	Orexin/Hypocretin receptor type 1	Homo sapiens		<100.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373197	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373197&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			71715445	404342299							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740909	CC1CCCC(CNC(=O)c2cccc3occc23)N1C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C27H26FN3O3S/c1-16-5-3-6-20(15-29-26(32)22-7-4-8-23-21(22)13-14-34-23)31(16)27(33)24-25(35-17(2)30-24)18-9-11-19(28)12-10-18/h4,7-14,16,20H,3,5-6,15H2,1-2H3,(H,29,32)	OZQQWERPXKWLAA-UHFFFAOYSA-N	373198	US9896452, Example 58::rac-N-((1-(5-(4-fluorophenyl)-2-methylthiazole-4-carbonyl)-6-methylpiperidin-2-yl)methyl)benzofuran-4-carboxamide	Orexin/Hypocretin receptor type 1	Homo sapiens		 1.000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373198	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373198&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			77913180	404342300							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740910	CC1CCCC(CNC(=O)c2cccc3occc23)N1C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C27H26FN3O3S/c1-16-5-3-6-20(15-29-26(32)22-7-4-8-23-21(22)13-14-34-23)31(16)27(33)24-25(35-17(2)30-24)18-9-11-19(28)12-10-18/h4,7-14,16,20H,3,5-6,15H2,1-2H3,(H,29,32)	OZQQWERPXKWLAA-UHFFFAOYSA-N	373198	US9896452, Example 58::rac-N-((1-(5-(4-fluorophenyl)-2-methylthiazole-4-carbonyl)-6-methylpiperidin-2-yl)methyl)benzofuran-4-carboxamide	Orexin receptor type 2	Homo sapiens		 8.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373198	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373198&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			77913180	404342300							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740911	CC1CCCC(CNC(=O)c2cccc3cccnc23)N1C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C28H27FN4O2S/c1-17-6-3-9-22(16-31-27(34)23-10-4-7-19-8-5-15-30-24(19)23)33(17)28(35)25-26(36-18(2)32-25)20-11-13-21(29)14-12-20/h4-5,7-8,10-15,17,22H,3,6,9,16H2,1-2H3,(H,31,34)	QDFUSTLNIXAUHP-UHFFFAOYSA-N	373199	US9896452, Example 59::rac-N-((1-(5-(4-fluorophenyl)-2-methylthiazole-4-carbonyl)-6-methylpiperidin-2-yl)methyl)quinoline-8-carboxamide	Orexin/Hypocretin receptor type 1	Homo sapiens		 40.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373199	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373199&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			71715447	404342301							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740912	CC1CCCC(CNC(=O)c2cccc3cccnc23)N1C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C28H27FN4O2S/c1-17-6-3-9-22(16-31-27(34)23-10-4-7-19-8-5-15-30-24(19)23)33(17)28(35)25-26(36-18(2)32-25)20-11-13-21(29)14-12-20/h4-5,7-8,10-15,17,22H,3,6,9,16H2,1-2H3,(H,31,34)	QDFUSTLNIXAUHP-UHFFFAOYSA-N	373199	US9896452, Example 59::rac-N-((1-(5-(4-fluorophenyl)-2-methylthiazole-4-carbonyl)-6-methylpiperidin-2-yl)methyl)quinoline-8-carboxamide	Orexin receptor type 2	Homo sapiens		 1200							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373199	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373199&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			71715447	404342301							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740913	COc1c(F)cccc1C(=O)NCC1CCCC(C)N1C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C26H27F2N3O3S/c1-15-6-4-7-19(14-29-25(32)20-8-5-9-21(28)23(20)34-3)31(15)26(33)22-24(35-16(2)30-22)17-10-12-18(27)13-11-17/h5,8-13,15,19H,4,6-7,14H2,1-3H3,(H,29,32)	BJMYJAPKIHPIPW-UHFFFAOYSA-N	373200	US9896452, Example 60::rac-3-Fluoro-N-((1-(5-(4-fluorophenyl)-2-methylthiazole-4-carbonyl)-6-methylpiperidin-2-yl)methyl)-2-methoxybenzamide	Orexin/Hypocretin receptor type 1	Homo sapiens		 1.000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373200	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373200&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			71715448	404342302							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740914	COc1c(F)cccc1C(=O)NCC1CCCC(C)N1C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C26H27F2N3O3S/c1-15-6-4-7-19(14-29-25(32)20-8-5-9-21(28)23(20)34-3)31(15)26(33)22-24(35-16(2)30-22)17-10-12-18(27)13-11-17/h5,8-13,15,19H,4,6-7,14H2,1-3H3,(H,29,32)	BJMYJAPKIHPIPW-UHFFFAOYSA-N	373200	US9896452, Example 60::rac-3-Fluoro-N-((1-(5-(4-fluorophenyl)-2-methylthiazole-4-carbonyl)-6-methylpiperidin-2-yl)methyl)-2-methoxybenzamide	Orexin receptor type 2	Homo sapiens		 370							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373200	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373200&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			71715448	404342302							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740915	CC1CCCC(CNC(=O)c2cccc3oc(C)cc23)N1C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C28H28FN3O3S/c1-16-6-4-7-21(15-30-27(33)22-8-5-9-24-23(22)14-17(2)35-24)32(16)28(34)25-26(36-18(3)31-25)19-10-12-20(29)13-11-19/h5,8-14,16,21H,4,6-7,15H2,1-3H3,(H,30,33)	JAUIDCOPUGAEFY-UHFFFAOYSA-N	373201	US9896452, Example 61::rac-N-((1-(5-(4-fluorophenyl)-2-methylthiazole-4-carbonyl)-6-methylpiperidin-2-yl)methyl)-2-methylbenzofuran-4-carboxamide	Orexin/Hypocretin receptor type 1	Homo sapiens		 7.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373201	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373201&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			71715446	404342303							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740916	CC1CCCC(CNC(=O)c2cccc3oc(C)cc23)N1C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C28H28FN3O3S/c1-16-6-4-7-21(15-30-27(33)22-8-5-9-24-23(22)14-17(2)35-24)32(16)28(34)25-26(36-18(3)31-25)19-10-12-20(29)13-11-19/h5,8-14,16,21H,4,6-7,15H2,1-3H3,(H,30,33)	JAUIDCOPUGAEFY-UHFFFAOYSA-N	373201	US9896452, Example 61::rac-N-((1-(5-(4-fluorophenyl)-2-methylthiazole-4-carbonyl)-6-methylpiperidin-2-yl)methyl)-2-methylbenzofuran-4-carboxamide	Orexin receptor type 2	Homo sapiens		 380							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373201	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373201&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			71715446	404342303							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740917	C[C@@H]1CCCN([C@@H]1CNC(=O)c1cccc2occc12)C(=O)c1nc(C)sc1-c1ccccc1	InChI=1S/C27H27N3O3S/c1-17-8-7-14-30(27(32)24-25(34-18(2)29-24)19-9-4-3-5-10-19)22(17)16-28-26(31)21-11-6-12-23-20(21)13-15-33-23/h3-6,9-13,15,17,22H,7-8,14,16H2,1-2H3,(H,28,31)/t17-,22-/m1/s1	ZSFKTFCHCZQVDT-VGOFRKELSA-N	50384423	CHEMBL2031485::US9896452, Example 62	Orexin/Hypocretin receptor type 1	Homo sapiens		 1.000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50384423	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50384423&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			70683741	160863506		CHEMBL2031485				ZINC84652894	1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740918	C[C@@H]1CCCN([C@@H]1CNC(=O)c1cccc2occc12)C(=O)c1nc(C)sc1-c1ccccc1	InChI=1S/C27H27N3O3S/c1-17-8-7-14-30(27(32)24-25(34-18(2)29-24)19-9-4-3-5-10-19)22(17)16-28-26(31)21-11-6-12-23-20(21)13-15-33-23/h3-6,9-13,15,17,22H,7-8,14,16H2,1-2H3,(H,28,31)/t17-,22-/m1/s1	ZSFKTFCHCZQVDT-VGOFRKELSA-N	50384423	CHEMBL2031485::US9896452, Example 62	Orexin receptor type 2	Homo sapiens		 8.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50384423	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50384423&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			70683741	160863506		CHEMBL2031485				ZINC84652894	1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740919	C[C@@H]1CCCN([C@@H]1CNC(=O)c1cccc2occc12)C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C27H26FN3O3S/c1-16-5-4-13-31(22(16)15-29-26(32)21-6-3-7-23-20(21)12-14-34-23)27(33)24-25(35-17(2)30-24)18-8-10-19(28)11-9-18/h3,6-12,14,16,22H,4-5,13,15H2,1-2H3,(H,29,32)/t16-,22-/m1/s1	MMZJCOGZVWFSAF-OPAMFIHVSA-N	373203	US9896452, Example 63::rac-N-(((2S,3R)-1-(5-(4-fluorophenyl)-2-methylthiazole-4-carbonyl)-3-methylpiperidin-2-yl)methyl)benzofuran-4-carboxamide	Orexin/Hypocretin receptor type 1	Homo sapiens		 2.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373203	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373203&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89739395	404342305							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740920	C[C@@H]1CCCN([C@@H]1CNC(=O)c1cccc2occc12)C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C27H26FN3O3S/c1-16-5-4-13-31(22(16)15-29-26(32)21-6-3-7-23-20(21)12-14-34-23)27(33)24-25(35-17(2)30-24)18-8-10-19(28)11-9-18/h3,6-12,14,16,22H,4-5,13,15H2,1-2H3,(H,29,32)/t16-,22-/m1/s1	MMZJCOGZVWFSAF-OPAMFIHVSA-N	373203	US9896452, Example 63::rac-N-(((2S,3R)-1-(5-(4-fluorophenyl)-2-methylthiazole-4-carbonyl)-3-methylpiperidin-2-yl)methyl)benzofuran-4-carboxamide	Orexin receptor type 2	Homo sapiens		 48.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373203	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373203&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			89739395	404342305							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740921	Cc1nc(c(s1)C(=O)N1C[C@@H]2CCCC[C@@H]2[C@H]1CNC(=O)c1cccc2cccnc12)-c1ccccc1	InChI=1S/C30H30N4O2S/c1-19-33-27(21-9-3-2-4-10-21)28(37-19)30(36)34-18-22-11-5-6-14-23(22)25(34)17-32-29(35)24-15-7-12-20-13-8-16-31-26(20)24/h2-4,7-10,12-13,15-16,22-23,25H,5-6,11,14,17-18H2,1H3,(H,32,35)/t22-,23-,25+/m0/s1	UIXGWGUSLZNLNP-SONWIMMPSA-N	373204	US9896452, Example 64	Orexin/Hypocretin receptor type 1	Homo sapiens		 3000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373204	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373204&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			71715499	404342306							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740922	Cc1nc(c(s1)C(=O)N1C[C@H]2CCCC[C@@H]2[C@H]1CNC(=O)c1cccc2cccnc12)-c1ccccc1	InChI=1S/C30H30N4O2S/c1-19-33-27(21-9-3-2-4-10-21)28(37-19)30(36)34-18-22-11-5-6-14-23(22)25(34)17-32-29(35)24-15-7-12-20-13-8-16-31-26(20)24/h2-4,7-10,12-13,15-16,22-23,25H,5-6,11,14,17-18H2,1H3,(H,32,35)/t22-,23+,25-/m1/s1	UIXGWGUSLZNLNP-GIFXNVAJSA-N	373205	US9896452, Example 65::rac-N-(((1S,3aS,7aS)-2-(2-methyl-4-phenylthiazole-5-carbonyl)octahydro-1H-isoindol-1-yl)methyl)quinoline-8-carboxamide	Orexin/Hypocretin receptor type 1	Homo sapiens		>2000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373205	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373205&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			71715500	404342307							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740923	O=C(NC[C@@H]1[C@H]2CCCC[C@H]2CN1C(=O)c1ccccc1-c1ccccc1)c1cccc2cccnc12	InChI=1S/C32H31N3O2/c36-31(28-18-8-13-23-14-9-19-33-30(23)28)34-20-29-26-16-5-4-12-24(26)21-35(29)32(37)27-17-7-6-15-25(27)22-10-2-1-3-11-22/h1-3,6-11,13-15,17-19,24,26,29H,4-5,12,16,20-21H2,(H,34,36)/t24-,26-,29+/m0/s1	KIHHLTHMSWADNY-NJIBMQBXSA-N	373206	US9896452, Example 66	Orexin/Hypocretin receptor type 1	Homo sapiens		 350							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373206	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373206&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			71715501	404342308							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740924	O=C(NC[C@@H]1[C@H]2CCCC[C@@H]2CN1C(=O)c1ccccc1-c1ccccc1)c1cccc2cccnc12	InChI=1S/C32H31N3O2/c36-31(28-18-8-13-23-14-9-19-33-30(23)28)34-20-29-26-16-5-4-12-24(26)21-35(29)32(37)27-17-7-6-15-25(27)22-10-2-1-3-11-22/h1-3,6-11,13-15,17-19,24,26,29H,4-5,12,16,20-21H2,(H,34,36)/t24-,26+,29-/m1/s1	KIHHLTHMSWADNY-DOBADDLBSA-N	373207	US9896452, Example 67::rac-N-(((1S,3aS,7aS)-2-(biphenylcarbonyl)octahydro-1H-isoindol-1-yl)methyl)quinoline-8-carboxamide	Orexin/Hypocretin receptor type 1	Homo sapiens		 1000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373207	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373207&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			71715553	404342309							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740925	Cc1nc(C(=O)N2C[C@@H]3CCCC[C@@H]3[C@H]2CNC(=O)c2cccc3cccnc23)c(s1)-c1ccccc1	InChI=1S/C30H30N4O2S/c1-19-33-27(28(37-19)21-9-3-2-4-10-21)30(36)34-18-22-11-5-6-14-23(22)25(34)17-32-29(35)24-15-7-12-20-13-8-16-31-26(20)24/h2-4,7-10,12-13,15-16,22-23,25H,5-6,11,14,17-18H2,1H3,(H,32,35)/t22-,23-,25+/m0/s1	JAOZUYAWJXWHRX-SONWIMMPSA-N	373208	US9896452, Example 68	Orexin/Hypocretin receptor type 1	Homo sapiens		 120							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373208	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373208&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89748222	404342310							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740926	Cc1nc(C(=O)N2C[C@H]3CCCC[C@@H]3[C@H]2CNC(=O)c2cccc3cccnc23)c(s1)-c1ccccc1	InChI=1S/C30H30N4O2S/c1-19-33-27(28(37-19)21-9-3-2-4-10-21)30(36)34-18-22-11-5-6-14-23(22)25(34)17-32-29(35)24-15-7-12-20-13-8-16-31-26(20)24/h2-4,7-10,12-13,15-16,22-23,25H,5-6,11,14,17-18H2,1H3,(H,32,35)/t22-,23+,25-/m1/s1	JAOZUYAWJXWHRX-GIFXNVAJSA-N	373209	US9896452, Example 69::rac-N-(((1S,3aS,7aS)-2-(2-methyl-5-phenylthiazole-4-carbonyl)octahydro-1H-isoindol-1-yl)methyl)quinoline-8-carboxamide	Orexin/Hypocretin receptor type 1	Homo sapiens		 130							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373209	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373209&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89748221	404342311							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740927	Cc1nc(C(=O)N2C[C@@H]3CCCC[C@@H]3[C@H]2CNC(=O)c2cccc3occc23)c(s1)-c1ccccc1	InChI=1S/C29H29N3O3S/c1-18-31-26(27(36-18)19-8-3-2-4-9-19)29(34)32-17-20-10-5-6-11-21(20)24(32)16-30-28(33)23-12-7-13-25-22(23)14-15-35-25/h2-4,7-9,12-15,20-21,24H,5-6,10-11,16-17H2,1H3,(H,30,33)/t20-,21-,24+/m0/s1	BVNTZGWACXEDPE-AWRGLXIESA-N	373210	US9896452, Example 70	Orexin/Hypocretin receptor type 1	Homo sapiens		 170							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373210	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373210&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89748219	404342312							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740928	Cc1nc(C(=O)N2C[C@H]3CCCC[C@@H]3[C@H]2CNC(=O)c2cccc3occc23)c(s1)-c1ccccc1	InChI=1S/C29H29N3O3S/c1-18-31-26(27(36-18)19-8-3-2-4-9-19)29(34)32-17-20-10-5-6-11-21(20)24(32)16-30-28(33)23-12-7-13-25-22(23)14-15-35-25/h2-4,7-9,12-15,20-21,24H,5-6,10-11,16-17H2,1H3,(H,30,33)/t20-,21+,24-/m1/s1	BVNTZGWACXEDPE-ZFGGDYGUSA-N	373211	US9896452, Example 71::rac-N-(((1S,3aS,7aS)-2-(2-methyl-5-phenylthiazole-4-carbonyl)octahydro-1H-isoindol-1-yl)methyl)benzofuran-4-carboxamide	Orexin/Hypocretin receptor type 1	Homo sapiens		 40.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373211	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373211&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89748223	404342313							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740929	C[C@@H]1CCCN([C@@H]1CNc1nc2ccccc2s1)C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C25H25FN4OS2/c1-15-6-5-13-30(20(15)14-27-25-29-19-7-3-4-8-21(19)33-25)24(31)22-23(32-16(2)28-22)17-9-11-18(26)12-10-17/h3-4,7-12,15,20H,5-6,13-14H2,1-2H3,(H,27,29)/t15-,20-/m1/s1	ZWIPTFWKRJQHDY-FOIQADDNSA-N	373212	US9896452, Example 72::rac-((2S,3R)-2-((benzo[d]thiazol-2-ylamino)methyl)-3-methylpiperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone	Orexin/Hypocretin receptor type 1	Homo sapiens		 6.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373212	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373212&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89748224	404342314							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740930	C[C@@H]1CCCN([C@@H]1CNc1nc2ccccc2s1)C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C25H25FN4OS2/c1-15-6-5-13-30(20(15)14-27-25-29-19-7-3-4-8-21(19)33-25)24(31)22-23(32-16(2)28-22)17-9-11-18(26)12-10-17/h3-4,7-12,15,20H,5-6,13-14H2,1-2H3,(H,27,29)/t15-,20-/m1/s1	ZWIPTFWKRJQHDY-FOIQADDNSA-N	373212	US9896452, Example 72::rac-((2S,3R)-2-((benzo[d]thiazol-2-ylamino)methyl)-3-methylpiperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone	Orexin receptor type 2	Homo sapiens		>4000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373212	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373212&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			89748224	404342314							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740931	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1nc(C)sc1-c1ccccc1	InChI=1S/C24H25F3N4OS/c1-15-7-6-12-31(19(15)14-29-20-11-10-18(13-28-20)24(25,26)27)23(32)21-22(33-16(2)30-21)17-8-4-3-5-9-17/h3-5,8-11,13,15,19H,6-7,12,14H2,1-2H3,(H,28,29)/t15-,19-/m1/s1	YEUKTOYJDZDVSJ-DNVCBOLYSA-N	373213	US9896452, Example 73::rac-((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(2-methyl-5-phenylthiazol-4-yl)methanone	Orexin/Hypocretin receptor type 1	Homo sapiens		<10.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373213	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373213&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89748253	404342315							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740932	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1nc(C)sc1-c1ccccc1	InChI=1S/C24H25F3N4OS/c1-15-7-6-12-31(19(15)14-29-20-11-10-18(13-28-20)24(25,26)27)23(32)21-22(33-16(2)30-21)17-8-4-3-5-9-17/h3-5,8-11,13,15,19H,6-7,12,14H2,1-2H3,(H,28,29)/t15-,19-/m1/s1	YEUKTOYJDZDVSJ-DNVCBOLYSA-N	373213	US9896452, Example 73::rac-((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(2-methyl-5-phenylthiazol-4-yl)methanone	Orexin receptor type 2	Homo sapiens		>3000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373213	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373213&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			89748253	404342315							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740933	C[C@@H]1CCCN([C@@H]1CNc1cccc2cccnc12)C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C27H27FN4OS/c1-17-6-5-15-32(23(17)16-30-22-9-3-7-19-8-4-14-29-24(19)22)27(33)25-26(34-18(2)31-25)20-10-12-21(28)13-11-20/h3-4,7-14,17,23,30H,5-6,15-16H2,1-2H3/t17-,23-/m1/s1	LJNMFCVMGWSOPJ-UZUQRXQVSA-N	373214	US9896452, Example 74::rac-((2S,3R)-3-methyl-2-((quinolin-8-ylamino)methyl)piperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone	Orexin/Hypocretin receptor type 1	Homo sapiens		 58.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373214	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373214&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			71715610	404342316							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740934	C[C@@H]1CCCN([C@@H]1CNc1cccc2cccnc12)C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C27H27FN4OS/c1-17-6-5-15-32(23(17)16-30-22-9-3-7-19-8-4-14-29-24(19)22)27(33)25-26(34-18(2)31-25)20-10-12-21(28)13-11-20/h3-4,7-14,17,23,30H,5-6,15-16H2,1-2H3/t17-,23-/m1/s1	LJNMFCVMGWSOPJ-UZUQRXQVSA-N	373214	US9896452, Example 74::rac-((2S,3R)-3-methyl-2-((quinolin-8-ylamino)methyl)piperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373214	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373214&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			71715610	404342316							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740935	C[C@@H]1CCCN([C@@H]1CNc1ncc(cn1)C(F)(F)F)C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C23H23F4N5OS/c1-13-4-3-9-32(18(13)12-30-22-28-10-16(11-29-22)23(25,26)27)21(33)19-20(34-14(2)31-19)15-5-7-17(24)8-6-15/h5-8,10-11,13,18H,3-4,9,12H2,1-2H3,(H,28,29,30)/t13-,18-/m1/s1	BPQDADCPUWZLIG-FZKQIMNGSA-N	373133	US9896452, Example 75::rac-((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone	Orexin/Hypocretin receptor type 1	Homo sapiens		 3.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373133	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373133&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			71715611	404342238							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740936	C[C@@H]1CCCN([C@@H]1CNc1ncc(cn1)C(F)(F)F)C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C23H23F4N5OS/c1-13-4-3-9-32(18(13)12-30-22-28-10-16(11-29-22)23(25,26)27)21(33)19-20(34-14(2)31-19)15-5-7-17(24)8-6-15/h5-8,10-11,13,18H,3-4,9,12H2,1-2H3,(H,28,29,30)/t13-,18-/m1/s1	BPQDADCPUWZLIG-FZKQIMNGSA-N	373133	US9896452, Example 75::rac-((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone	Orexin receptor type 2	Homo sapiens		 3300							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373133	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373133&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			71715611	404342238							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740937	CC[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C25H26F4N4OS/c1-3-16-5-4-12-33(20(16)14-31-21-11-8-18(13-30-21)25(27,28)29)24(34)22-23(35-15(2)32-22)17-6-9-19(26)10-7-17/h6-11,13,16,20H,3-5,12,14H2,1-2H3,(H,30,31)/t16-,20-/m1/s1	AIXBROIGFFHFIB-OXQOHEQNSA-N	373215	US9896452, Example 76::rac-((2S,3R)-3-ethyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone	Orexin/Hypocretin receptor type 1	Homo sapiens		 300							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373215	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373215&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89739259	404342317							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740938	CC[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C25H26F4N4OS/c1-3-16-5-4-12-33(20(16)14-31-21-11-8-18(13-30-21)25(27,28)29)24(34)22-23(35-15(2)32-22)17-6-9-19(26)10-7-17/h6-11,13,16,20H,3-5,12,14H2,1-2H3,(H,30,31)/t16-,20-/m1/s1	AIXBROIGFFHFIB-OXQOHEQNSA-N	373215	US9896452, Example 76::rac-((2S,3R)-3-ethyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone	Orexin receptor type 2	Homo sapiens		>4000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373215	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373215&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			89739259	404342317							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740939	CC[C@@H]1CCCN([C@@H]1CNc1nc2ccccc2o1)C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C26H27FN4O2S/c1-3-17-7-6-14-31(21(17)15-28-26-30-20-8-4-5-9-22(20)33-26)25(32)23-24(34-16(2)29-23)18-10-12-19(27)13-11-18/h4-5,8-13,17,21H,3,6-7,14-15H2,1-2H3,(H,28,30)/t17-,21-/m1/s1	RAHSKXSDSAETLN-DYESRHJHSA-N	373216	US9896452, Example 77::rac-((2S,3R)-2-((benzo[d]oxazol-2-ylamino)methyl)-3-ethylpiperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone	Orexin/Hypocretin receptor type 1	Homo sapiens		 70.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373216	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373216&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89748252	404342318							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740940	CC[C@@H]1CCCN([C@@H]1CNc1nc2ccccc2o1)C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C26H27FN4O2S/c1-3-17-7-6-14-31(21(17)15-28-26-30-20-8-4-5-9-22(20)33-26)25(32)23-24(34-16(2)29-23)18-10-12-19(27)13-11-18/h4-5,8-13,17,21H,3,6-7,14-15H2,1-2H3,(H,28,30)/t17-,21-/m1/s1	RAHSKXSDSAETLN-DYESRHJHSA-N	373216	US9896452, Example 77::rac-((2S,3R)-2-((benzo[d]oxazol-2-ylamino)methyl)-3-ethylpiperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone	Orexin receptor type 2	Homo sapiens		>10000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373216	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373216&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			89748252	404342318							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740941	CC[C@@H]1CCCN([C@@H]1CNc1ncc(CC)cn1)C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C25H30FN5OS/c1-4-17-13-27-25(28-14-17)29-15-21-18(5-2)7-6-12-31(21)24(32)22-23(33-16(3)30-22)19-8-10-20(26)11-9-19/h8-11,13-14,18,21H,4-7,12,15H2,1-3H3,(H,27,28,29)/t18-,21-/m1/s1	SDKZGXUUHRVDAZ-WIYYLYMNSA-N	373217	US9896452, Example 78::rac-((2S,3R)-3-ethyl-2-(((5-ethylpyrimidin-2-yl)amino)methyl)piperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone	Orexin/Hypocretin receptor type 1	Homo sapiens		 2.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373217	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373217&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89739665	404342319							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740942	CC[C@@H]1CCCN([C@@H]1CNc1ncc(CC)cn1)C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C25H30FN5OS/c1-4-17-13-27-25(28-14-17)29-15-21-18(5-2)7-6-12-31(21)24(32)22-23(33-16(3)30-22)19-8-10-20(26)11-9-19/h8-11,13-14,18,21H,4-7,12,15H2,1-3H3,(H,27,28,29)/t18-,21-/m1/s1	SDKZGXUUHRVDAZ-WIYYLYMNSA-N	373217	US9896452, Example 78::rac-((2S,3R)-3-ethyl-2-(((5-ethylpyrimidin-2-yl)amino)methyl)piperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone	Orexin receptor type 2	Homo sapiens		>10000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373217	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373217&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			89739665	404342319							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740943	C[C@@H]1CCCN([C@@H]1COc1ccc(cn1)C(F)(F)F)C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C24H23F4N3O2S/c1-14-4-3-11-31(19(14)13-33-20-10-7-17(12-29-20)24(26,27)28)23(32)21-22(34-15(2)30-21)16-5-8-18(25)9-6-16/h5-10,12,14,19H,3-4,11,13H2,1-2H3/t14-,19-/m1/s1	JMPIATXFWNAJIK-AUUYWEPGSA-N	373218	US9896452, Example 79::rac-((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)oxy)methyl)piperidin-1-yl) (5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone	Orexin/Hypocretin receptor type 1	Homo sapiens		 1.000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373218	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373218&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89739407	404342320							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740944	C[C@@H]1CCCN([C@@H]1COc1ccc(cn1)C(F)(F)F)C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C24H23F4N3O2S/c1-14-4-3-11-31(19(14)13-33-20-10-7-17(12-29-20)24(26,27)28)23(32)21-22(34-15(2)30-21)16-5-8-18(25)9-6-16/h5-10,12,14,19H,3-4,11,13H2,1-2H3/t14-,19-/m1/s1	JMPIATXFWNAJIK-AUUYWEPGSA-N	373218	US9896452, Example 79::rac-((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)oxy)methyl)piperidin-1-yl) (5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone	Orexin receptor type 2	Homo sapiens		>10000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373218	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373218&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			89739407	404342320							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740945	C[C@@H]1CCCN([C@@H]1COc1nc2ccccc2o1)C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C25H24FN3O3S/c1-15-6-5-13-29(20(15)14-31-25-28-19-7-3-4-8-21(19)32-25)24(30)22-23(33-16(2)27-22)17-9-11-18(26)12-10-17/h3-4,7-12,15,20H,5-6,13-14H2,1-2H3/t15-,20-/m1/s1	GWXZQMCHFMLSDI-FOIQADDNSA-N	373219	US9896452, Example 80::rac-((2S,3R)-2-((benzo[d]oxazol-2-yloxy)methyl)-3-methylpiperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone	Orexin/Hypocretin receptor type 1	Homo sapiens		 140							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373219	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373219&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89748229	404342321							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740946	C[C@@H]1CCCN([C@@H]1COc1nc2ccccc2o1)C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C25H24FN3O3S/c1-15-6-5-13-29(20(15)14-31-25-28-19-7-3-4-8-21(19)32-25)24(30)22-23(33-16(2)27-22)17-9-11-18(26)12-10-17/h3-4,7-12,15,20H,5-6,13-14H2,1-2H3/t15-,20-/m1/s1	GWXZQMCHFMLSDI-FOIQADDNSA-N	373219	US9896452, Example 80::rac-((2S,3R)-2-((benzo[d]oxazol-2-yloxy)methyl)-3-methylpiperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone	Orexin receptor type 2	Homo sapiens		>10000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373219	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373219&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			89748229	404342321							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740947	CCc1cnc(OC[C@@H]2[C@H](C)CCCN2C(=O)c2nc(C)sc2-c2ccc(F)cc2)nc1	InChI=1S/C24H27FN4O2S/c1-4-17-12-26-24(27-13-17)31-14-20-15(2)6-5-11-29(20)23(30)21-22(32-16(3)28-21)18-7-9-19(25)10-8-18/h7-10,12-13,15,20H,4-6,11,14H2,1-3H3/t15-,20-/m1/s1	DSBRSKGUPLEZLR-FOIQADDNSA-N	373220	US9896452, Example 81::rac-((2S,3R)-2-(((5-ethylpyrimidin-2-yl)oxy)methyl)-3-methylpiperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone	Orexin/Hypocretin receptor type 1	Homo sapiens		<10.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373220	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373220&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89740501	404342322							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740948	CCc1cnc(OC[C@@H]2[C@H](C)CCCN2C(=O)c2nc(C)sc2-c2ccc(F)cc2)nc1	InChI=1S/C24H27FN4O2S/c1-4-17-12-26-24(27-13-17)31-14-20-15(2)6-5-11-29(20)23(30)21-22(32-16(3)28-21)18-7-9-19(25)10-8-18/h7-10,12-13,15,20H,4-6,11,14H2,1-3H3/t15-,20-/m1/s1	DSBRSKGUPLEZLR-FOIQADDNSA-N	373220	US9896452, Example 81::rac-((2S,3R)-2-(((5-ethylpyrimidin-2-yl)oxy)methyl)-3-methylpiperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone	Orexin receptor type 2	Homo sapiens		>10000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373220	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373220&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			89740501	404342322							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740949	C[C@@H]1CCCN([C@@H]1CNc1ncc(Cl)cn1)C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C22H23ClFN5OS/c1-13-4-3-9-29(18(13)12-27-22-25-10-16(23)11-26-22)21(30)19-20(31-14(2)28-19)15-5-7-17(24)8-6-15/h5-8,10-11,13,18H,3-4,9,12H2,1-2H3,(H,25,26,27)/t13-,18-/m1/s1	HOYRKLOSSPBUHN-FZKQIMNGSA-N	373221	US9896452, Ex. A41::US9896452, Example 82::rac-((2S,3R)-2-(((5-chloropyrimidin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone	Orexin/Hypocretin receptor type 1	Homo sapiens		 4.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373221	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373221&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89739388	404342323							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740950	C[C@@H]1CCCN([C@@H]1CNc1ncc(Cl)cn1)C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C22H23ClFN5OS/c1-13-4-3-9-29(18(13)12-27-22-25-10-16(23)11-26-22)21(30)19-20(31-14(2)28-19)15-5-7-17(24)8-6-15/h5-8,10-11,13,18H,3-4,9,12H2,1-2H3,(H,25,26,27)/t13-,18-/m1/s1	HOYRKLOSSPBUHN-FZKQIMNGSA-N	373221	US9896452, Ex. A41::US9896452, Example 82::rac-((2S,3R)-2-(((5-chloropyrimidin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone	Orexin receptor type 2	Homo sapiens		>10000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373221	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373221&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			89739388	404342323							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740951	C[C@@H]1CCCN([C@@H]1CNc1ncc(C)cn1)C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C23H26FN5OS/c1-14-11-25-23(26-12-14)27-13-19-15(2)5-4-10-29(19)22(30)20-21(31-16(3)28-20)17-6-8-18(24)9-7-17/h6-9,11-12,15,19H,4-5,10,13H2,1-3H3,(H,25,26,27)/t15-,19-/m1/s1	SDSSECRWBGUVRU-DNVCBOLYSA-N	373222	US9896452, Example 83::rac-((2S,3R)-3-methyl-2-(((5-methylpyrimidin-2-yl)amino)methyl)piperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone	Orexin/Hypocretin receptor type 1	Homo sapiens		 30.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373222	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373222&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89748260	404342324							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740952	C[C@@H]1CCCN([C@@H]1CNc1ncc(C)cn1)C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C23H26FN5OS/c1-14-11-25-23(26-12-14)27-13-19-15(2)5-4-10-29(19)22(30)20-21(31-16(3)28-20)17-6-8-18(24)9-7-17/h6-9,11-12,15,19H,4-5,10,13H2,1-3H3,(H,25,26,27)/t15-,19-/m1/s1	SDSSECRWBGUVRU-DNVCBOLYSA-N	373222	US9896452, Example 83::rac-((2S,3R)-3-methyl-2-(((5-methylpyrimidin-2-yl)amino)methyl)piperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone	Orexin receptor type 2	Homo sapiens		>10000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373222	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373222&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			89748260	404342324							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740953	CC(C)[C@@H]1CCCN([C@@H]1CNc1nc2ccccc2o1)C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C27H29FN4O2S/c1-16(2)20-7-6-14-32(22(20)15-29-27-31-21-8-4-5-9-23(21)34-27)26(33)24-25(35-17(3)30-24)18-10-12-19(28)13-11-18/h4-5,8-13,16,20,22H,6-7,14-15H2,1-3H3,(H,29,31)/t20-,22+/m0/s1	WRUGARCFVRLOJE-RBBKRZOGSA-N	373223	US9896452, Example 84::rac-((2S,3S)-2-((benzo[d]oxazol-2-ylamino)methyl)-3-isopropylpiperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone	Orexin/Hypocretin receptor type 1	Homo sapiens		 35.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373223	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373223&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89739884	404342325							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740954	CC(C)[C@@H]1CCCN([C@@H]1CNc1nc2ccccc2o1)C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C27H29FN4O2S/c1-16(2)20-7-6-14-32(22(20)15-29-27-31-21-8-4-5-9-23(21)34-27)26(33)24-25(35-17(3)30-24)18-10-12-19(28)13-11-18/h4-5,8-13,16,20,22H,6-7,14-15H2,1-3H3,(H,29,31)/t20-,22+/m0/s1	WRUGARCFVRLOJE-RBBKRZOGSA-N	373223	US9896452, Example 84::rac-((2S,3S)-2-((benzo[d]oxazol-2-ylamino)methyl)-3-isopropylpiperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone	Orexin receptor type 2	Homo sapiens		>10000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373223	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373223&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			89739884	404342325							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740955	C[C@@H]1CCCN([C@@H]1CNc1ccc(F)cn1)C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C23H24F2N4OS/c1-14-4-3-11-29(19(14)13-27-20-10-9-18(25)12-26-20)23(30)21-22(31-15(2)28-21)16-5-7-17(24)8-6-16/h5-10,12,14,19H,3-4,11,13H2,1-2H3,(H,26,27)/t14-,19-/m1/s1	PEJCEFOPMCQMHH-AUUYWEPGSA-N	373224	US9896452, Example 85::rac-((2S,3R)-2-(((5-fluoropyridin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone	Orexin/Hypocretin receptor type 1	Homo sapiens		 100.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373224	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373224&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89748264	404342326							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740956	C[C@@H]1CCCN([C@@H]1CNc1ccc(F)cn1)C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C23H24F2N4OS/c1-14-4-3-11-29(19(14)13-27-20-10-9-18(25)12-26-20)23(30)21-22(31-15(2)28-21)16-5-7-17(24)8-6-16/h5-10,12,14,19H,3-4,11,13H2,1-2H3,(H,26,27)/t14-,19-/m1/s1	PEJCEFOPMCQMHH-AUUYWEPGSA-N	373224	US9896452, Example 85::rac-((2S,3R)-2-(((5-fluoropyridin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone	Orexin receptor type 2	Homo sapiens		>10000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373224	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373224&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			89748264	404342326							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740957	C[C@@H]1CCCN([C@@H]1CNc1ccc(C)cn1)C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C24H27FN4OS/c1-15-6-11-21(26-13-15)27-14-20-16(2)5-4-12-29(20)24(30)22-23(31-17(3)28-22)18-7-9-19(25)10-8-18/h6-11,13,16,20H,4-5,12,14H2,1-3H3,(H,26,27)/t16-,20-/m1/s1	VULABSKJDXVOCQ-OXQOHEQNSA-N	373225	US9896452, Example 86::rac-((2S,3R)-3-methyl-2-(((5-methylpyridin-2-yl)amino)methyl)piperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone	Orexin/Hypocretin receptor type 1	Homo sapiens		 22.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373225	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373225&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89740336	404342327							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740958	C[C@@H]1CCCN([C@@H]1CNc1ccc(C)cn1)C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C24H27FN4OS/c1-15-6-11-21(26-13-15)27-14-20-16(2)5-4-12-29(20)24(30)22-23(31-17(3)28-22)18-7-9-19(25)10-8-18/h6-11,13,16,20H,4-5,12,14H2,1-3H3,(H,26,27)/t16-,20-/m1/s1	VULABSKJDXVOCQ-OXQOHEQNSA-N	373225	US9896452, Example 86::rac-((2S,3R)-3-methyl-2-(((5-methylpyridin-2-yl)amino)methyl)piperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone	Orexin receptor type 2	Homo sapiens		>10000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373225	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373225&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			89740336	404342327							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740959	C[C@@H]1CCCN([C@@H]1CNc1cccc(n1)C(F)(F)F)C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C24H24F4N4OS/c1-14-5-4-12-32(18(14)13-29-20-7-3-6-19(31-20)24(26,27)28)23(33)21-22(34-15(2)30-21)16-8-10-17(25)11-9-16/h3,6-11,14,18H,4-5,12-13H2,1-2H3,(H,29,31)/t14-,18-/m1/s1	VKEAHVIDNQNCHK-RDTXWAMCSA-N	373226	US9896452, Example 87::rac-((2S,3R)-3-methyl-2-(((6-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone	Orexin/Hypocretin receptor type 1	Homo sapiens		 220							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373226	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373226&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89741589	404342328							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740960	C[C@@H]1CCCN([C@@H]1CNc1cccc(n1)C(F)(F)F)C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C24H24F4N4OS/c1-14-5-4-12-32(18(14)13-29-20-7-3-6-19(31-20)24(26,27)28)23(33)21-22(34-15(2)30-21)16-8-10-17(25)11-9-16/h3,6-11,14,18H,4-5,12-13H2,1-2H3,(H,29,31)/t14-,18-/m1/s1	VKEAHVIDNQNCHK-RDTXWAMCSA-N	373226	US9896452, Example 87::rac-((2S,3R)-3-methyl-2-(((6-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone	Orexin receptor type 2	Homo sapiens		 70.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373226	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373226&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			89741589	404342328							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740961	COc1cnc(NC[C@@H]2[C@H](C)CCCN2C(=O)c2nc(C)sc2-c2ccc(F)cc2)nc1	InChI=1S/C23H26FN5O2S/c1-14-5-4-10-29(19(14)13-27-23-25-11-18(31-3)12-26-23)22(30)20-21(32-15(2)28-20)16-6-8-17(24)9-7-16/h6-9,11-12,14,19H,4-5,10,13H2,1-3H3,(H,25,26,27)/t14-,19-/m1/s1	UOVPBTKFHVQTMJ-AUUYWEPGSA-N	373227	US9896452, Example 88::rac-((2S,3R)-2-(((5-methoxypyrimidin-2-yl)amino)methyl)-3-methylpiperidin-1-yl) (5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone	Orexin/Hypocretin receptor type 1	Homo sapiens		 42.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373227	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373227&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89748262	404342329							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740962	COc1cnc(NC[C@@H]2[C@H](C)CCCN2C(=O)c2nc(C)sc2-c2ccc(F)cc2)nc1	InChI=1S/C23H26FN5O2S/c1-14-5-4-10-29(19(14)13-27-23-25-11-18(31-3)12-26-23)22(30)20-21(32-15(2)28-20)16-6-8-17(24)9-7-16/h6-9,11-12,14,19H,4-5,10,13H2,1-3H3,(H,25,26,27)/t14-,19-/m1/s1	UOVPBTKFHVQTMJ-AUUYWEPGSA-N	373227	US9896452, Example 88::rac-((2S,3R)-2-(((5-methoxypyrimidin-2-yl)amino)methyl)-3-methylpiperidin-1-yl) (5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone	Orexin receptor type 2	Homo sapiens		>10000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373227	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373227&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			89748262	404342329							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740963	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C#N)C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C24H24FN5OS/c1-15-4-3-11-30(20(15)14-28-21-10-5-17(12-26)13-27-21)24(31)22-23(32-16(2)29-22)18-6-8-19(25)9-7-18/h5-10,13,15,20H,3-4,11,14H2,1-2H3,(H,27,28)/t15-,20-/m1/s1	HAHNLZKLQMINNS-FOIQADDNSA-N	373228	US9896452, Example 91::rac-6-((((2S,3R)-1-(5-(4-fluorophenyl)-2-methylthiazole-4-carbonyl)-3-methylpiperidin-2-yl)methyl)amino)nicotinonitrile	Orexin/Hypocretin receptor type 1	Homo sapiens		 140							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373228	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373228&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89748245	404342330							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740964	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C#N)C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C24H24FN5OS/c1-15-4-3-11-30(20(15)14-28-21-10-5-17(12-26)13-27-21)24(31)22-23(32-16(2)29-22)18-6-8-19(25)9-7-18/h5-10,13,15,20H,3-4,11,14H2,1-2H3,(H,27,28)/t15-,20-/m1/s1	HAHNLZKLQMINNS-FOIQADDNSA-N	373228	US9896452, Example 91::rac-6-((((2S,3R)-1-(5-(4-fluorophenyl)-2-methylthiazole-4-carbonyl)-3-methylpiperidin-2-yl)methyl)amino)nicotinonitrile	Orexin receptor type 2	Homo sapiens		>10000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373228	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373228&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			89748245	404342330							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740965	CO[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C24H24F4N4O2S/c1-14-31-21(22(35-14)15-5-8-17(25)9-6-15)23(33)32-11-3-4-19(34-2)18(32)13-30-20-10-7-16(12-29-20)24(26,27)28/h5-10,12,18-19H,3-4,11,13H2,1-2H3,(H,29,30)/t18-,19-/m1/s1	IMJHMXBESPESOA-RTBURBONSA-N	373229	US9896452, Example 92::rac-((2R,3R)-3-methoxy-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone	Orexin/Hypocretin receptor type 1	Homo sapiens		 560							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373229	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373229&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89741791	404342331							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740966	CO[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C24H24F4N4O2S/c1-14-31-21(22(35-14)15-5-8-17(25)9-6-15)23(33)32-11-3-4-19(34-2)18(32)13-30-20-10-7-16(12-29-20)24(26,27)28/h5-10,12,18-19H,3-4,11,13H2,1-2H3,(H,29,30)/t18-,19-/m1/s1	IMJHMXBESPESOA-RTBURBONSA-N	373229	US9896452, Example 92::rac-((2R,3R)-3-methoxy-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone	Orexin receptor type 2	Homo sapiens		>4000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373229	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373229&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			89741791	404342331							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740967	CO[C@@H]1CCCN([C@@H]1CNc1ncc(Cl)cn1)C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C22H23ClFN5O2S/c1-13-28-19(20(32-13)14-5-7-16(24)8-6-14)21(30)29-9-3-4-18(31-2)17(29)12-27-22-25-10-15(23)11-26-22/h5-8,10-11,17-18H,3-4,9,12H2,1-2H3,(H,25,26,27)/t17-,18-/m1/s1	BEDGJTYZISAOJW-QZTJIDSGSA-N	373230	US9896452, Example 93::rac-((2R,3R)-2-(((5-chloropyrimidin-2-yl)amino)methyl)-3-methoxypiperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone	Orexin/Hypocretin receptor type 1	Homo sapiens		 100.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373230	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373230&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89739571	404342332							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740968	CO[C@@H]1CCCN([C@@H]1CNc1ncc(Cl)cn1)C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C22H23ClFN5O2S/c1-13-28-19(20(32-13)14-5-7-16(24)8-6-14)21(30)29-9-3-4-18(31-2)17(29)12-27-22-25-10-15(23)11-26-22/h5-8,10-11,17-18H,3-4,9,12H2,1-2H3,(H,25,26,27)/t17-,18-/m1/s1	BEDGJTYZISAOJW-QZTJIDSGSA-N	373230	US9896452, Example 93::rac-((2R,3R)-2-(((5-chloropyrimidin-2-yl)amino)methyl)-3-methoxypiperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone	Orexin receptor type 2	Homo sapiens		>1000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373230	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373230&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			89739571	404342332							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740969	CO[C@@H]1CCCN([C@@H]1CNc1nc2ccccc2s1)C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C25H25FN4O2S2/c1-15-28-22(23(33-15)16-9-11-17(26)12-10-16)24(31)30-13-5-7-20(32-2)19(30)14-27-25-29-18-6-3-4-8-21(18)34-25/h3-4,6,8-12,19-20H,5,7,13-14H2,1-2H3,(H,27,29)/t19-,20-/m1/s1	CYMHMGCQAISJKN-WOJBJXKFSA-N	373231	US9896452, Example 94::rac-((2R,3R)-2-((benzo[d]thiazol-2-ylamino)methyl)-3-methoxypiperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone	Orexin/Hypocretin receptor type 1	Homo sapiens		 76.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373231	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373231&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89748231	404342333							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740970	CO[C@@H]1CCCN([C@@H]1CNc1nc2ccccc2s1)C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C25H25FN4O2S2/c1-15-28-22(23(33-15)16-9-11-17(26)12-10-16)24(31)30-13-5-7-20(32-2)19(30)14-27-25-29-18-6-3-4-8-21(18)34-25/h3-4,6,8-12,19-20H,5,7,13-14H2,1-2H3,(H,27,29)/t19-,20-/m1/s1	CYMHMGCQAISJKN-WOJBJXKFSA-N	373231	US9896452, Example 94::rac-((2R,3R)-2-((benzo[d]thiazol-2-ylamino)methyl)-3-methoxypiperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone	Orexin receptor type 2	Homo sapiens		 1000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373231	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373231&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			89748231	404342333							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740971	C[C@H]1CCCN([C@@H]1CNc1nc2ccccc2o1)C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C25H25FN4O2S/c1-15-6-5-13-30(20(15)14-27-25-29-19-7-3-4-8-21(19)32-25)24(31)22-23(33-16(2)28-22)17-9-11-18(26)12-10-17/h3-4,7-12,15,20H,5-6,13-14H2,1-2H3,(H,27,29)/t15-,20+/m0/s1	RSCBRJAESFFMDG-MGPUTAFESA-N	373232	US9896452, Example 95::rac-((2R,3R)-2-((benzo[d]oxazol-2-ylamino)methyl)-3-methylpiperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone	Orexin/Hypocretin receptor type 1	Homo sapiens		 29.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373232	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373232&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89748239	404342334							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740972	C[C@H]1CCCN([C@@H]1CNc1nc2ccccc2o1)C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C25H25FN4O2S/c1-15-6-5-13-30(20(15)14-27-25-29-19-7-3-4-8-21(19)32-25)24(31)22-23(33-16(2)28-22)17-9-11-18(26)12-10-17/h3-4,7-12,15,20H,5-6,13-14H2,1-2H3,(H,27,29)/t15-,20+/m0/s1	RSCBRJAESFFMDG-MGPUTAFESA-N	373232	US9896452, Example 95::rac-((2R,3R)-2-((benzo[d]oxazol-2-ylamino)methyl)-3-methylpiperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone	Orexin receptor type 2	Homo sapiens		 253							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373232	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373232&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			89748239	404342334							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740973	C[C@H]1CCCN([C@@H]1CNc1ncc(Cl)cn1)C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C22H23ClFN5OS/c1-13-4-3-9-29(18(13)12-27-22-25-10-16(23)11-26-22)21(30)19-20(31-14(2)28-19)15-5-7-17(24)8-6-15/h5-8,10-11,13,18H,3-4,9,12H2,1-2H3,(H,25,26,27)/t13-,18+/m0/s1	HOYRKLOSSPBUHN-SCLBCKFNSA-N	373233	US9896452, Example 96::rac-((2R,3R)-2-(((5-chloropyrimidin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone	Orexin/Hypocretin receptor type 1	Homo sapiens		 18.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373233	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373233&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89748241	404342335							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740974	C[C@H]1CCCN([C@@H]1CNc1ncc(Cl)cn1)C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C22H23ClFN5OS/c1-13-4-3-9-29(18(13)12-27-22-25-10-16(23)11-26-22)21(30)19-20(31-14(2)28-19)15-5-7-17(24)8-6-15/h5-8,10-11,13,18H,3-4,9,12H2,1-2H3,(H,25,26,27)/t13-,18+/m0/s1	HOYRKLOSSPBUHN-SCLBCKFNSA-N	373233	US9896452, Example 96::rac-((2R,3R)-2-(((5-chloropyrimidin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone	Orexin receptor type 2	Homo sapiens		 1400							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373233	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373233&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			89748241	404342335							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740975	C[C@@H]1CCCN([C@@H]1CNc1ncc(cn1)C(F)(F)F)C(=O)c1cc(C)ccc1-n1nccn1	InChI=1S/C22H24F3N7O/c1-14-5-6-18(32-29-7-8-30-32)17(10-14)20(33)31-9-3-4-15(2)19(31)13-28-21-26-11-16(12-27-21)22(23,24)25/h5-8,10-12,15,19H,3-4,9,13H2,1-2H3,(H,26,27,28)/t15-,19-/m1/s1	UOFUCJWLSMCUJD-DNVCBOLYSA-N	373234	US9896452, Ex. A149::US9896452, Example 97::rac-((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone	Orexin/Hypocretin receptor type 1	Homo sapiens		 9.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373234	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373234&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89748240	404342336							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740976	C[C@@H]1CCCN([C@@H]1CNc1ncc(cn1)C(F)(F)F)C(=O)c1cc(C)ccc1-n1nccn1	InChI=1S/C22H24F3N7O/c1-14-5-6-18(32-29-7-8-30-32)17(10-14)20(33)31-9-3-4-15(2)19(31)13-28-21-26-11-16(12-27-21)22(23,24)25/h5-8,10-12,15,19H,3-4,9,13H2,1-2H3,(H,26,27,28)/t15-,19-/m1/s1	UOFUCJWLSMCUJD-DNVCBOLYSA-N	373234	US9896452, Ex. A149::US9896452, Example 97::rac-((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone	Orexin receptor type 2	Homo sapiens		>10000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373234	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373234&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			89748240	404342336							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740977	C[C@@H]1CCCN([C@@H]1CNc1ncc(Cl)cn1)C(=O)c1cc(C)ccc1-n1nccn1	InChI=1S/C21H24ClN7O/c1-14-5-6-18(29-26-7-8-27-29)17(10-14)20(30)28-9-3-4-15(2)19(28)13-25-21-23-11-16(22)12-24-21/h5-8,10-12,15,19H,3-4,9,13H2,1-2H3,(H,23,24,25)/t15-,19-/m1/s1	NGSXSHQBMOQXPL-DNVCBOLYSA-N	373235	US9896452, Ex. A147::US9896452, Example 98::rac-((2S,3R)-2-(((5-chloropyrimidin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone	Orexin/Hypocretin receptor type 1	Homo sapiens		 6.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373235	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373235&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89748215	404342337							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740978	C[C@@H]1CCCN([C@@H]1CNc1ncc(Cl)cn1)C(=O)c1cc(C)ccc1-n1nccn1	InChI=1S/C21H24ClN7O/c1-14-5-6-18(29-26-7-8-27-29)17(10-14)20(30)28-9-3-4-15(2)19(28)13-25-21-23-11-16(22)12-24-21/h5-8,10-12,15,19H,3-4,9,13H2,1-2H3,(H,23,24,25)/t15-,19-/m1/s1	NGSXSHQBMOQXPL-DNVCBOLYSA-N	373235	US9896452, Ex. A147::US9896452, Example 98::rac-((2S,3R)-2-(((5-chloropyrimidin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone	Orexin receptor type 2	Homo sapiens		>10000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373235	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373235&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			89748215	404342337							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740979	Cc1nc(C(=O)N2C[C@H]3CCC[C@H]3C2CNc2ncc(cn2)C(F)(F)F)c(s1)-c1ccc(F)cc1	InChI=1S/C24H23F4N5OS/c1-13-32-20(21(35-13)14-5-7-17(25)8-6-14)22(34)33-12-15-3-2-4-18(15)19(33)11-31-23-29-9-16(10-30-23)24(26,27)28/h5-10,15,18-19H,2-4,11-12H2,1H3,(H,29,30,31)/t15-,18-,19?/m1/s1	LAJSQFSKBDATIW-AOQMIGQVSA-N	373236	US9896452, Example 99::rac-(5-(4-fluorophenyl)-2-methylthiazol-4-yl)(1-(hydroxymethyl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)methanone	Orexin/Hypocretin receptor type 1	Homo sapiens		 82.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373236	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373236&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89748244	404342338							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740980	Cc1nc(C(=O)N2C[C@H]3CCC[C@H]3C2CNc2ncc(cn2)C(F)(F)F)c(s1)-c1ccc(F)cc1	InChI=1S/C24H23F4N5OS/c1-13-32-20(21(35-13)14-5-7-17(25)8-6-14)22(34)33-12-15-3-2-4-18(15)19(33)11-31-23-29-9-16(10-30-23)24(26,27)28/h5-10,15,18-19H,2-4,11-12H2,1H3,(H,29,30,31)/t15-,18-,19?/m1/s1	LAJSQFSKBDATIW-AOQMIGQVSA-N	373236	US9896452, Example 99::rac-(5-(4-fluorophenyl)-2-methylthiazol-4-yl)(1-(hydroxymethyl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)methanone	Orexin receptor type 2	Homo sapiens		 5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373236	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373236&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			89748244	404342338							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740981	Cc1nc(C(=O)N2C[C@H]3CCC[C@H]3C2CNc2nc3ccccc3o2)c(s1)-c1ccc(F)cc1	InChI=1S/C26H25FN4O2S/c1-15-29-23(24(34-15)16-9-11-18(27)12-10-16)25(32)31-14-17-5-4-6-19(17)21(31)13-28-26-30-20-7-2-3-8-22(20)33-26/h2-3,7-12,17,19,21H,4-6,13-14H2,1H3,(H,28,30)/t17-,19-,21?/m1/s1	CVTJXLVBXLTRFM-ONTUJTEPSA-N	373237	US9896452, Example 100::rac-(1-((benzo[d]oxazol-2-ylamino)methyl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone	Orexin/Hypocretin receptor type 1	Homo sapiens		 8.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373237	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373237&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89748230	404342339							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740982	Cc1nc(C(=O)N2C[C@H]3CCC[C@H]3C2CNc2nc3ccccc3o2)c(s1)-c1ccc(F)cc1	InChI=1S/C26H25FN4O2S/c1-15-29-23(24(34-15)16-9-11-18(27)12-10-16)25(32)31-14-17-5-4-6-19(17)21(31)13-28-26-30-20-7-2-3-8-22(20)33-26/h2-3,7-12,17,19,21H,4-6,13-14H2,1H3,(H,28,30)/t17-,19-,21?/m1/s1	CVTJXLVBXLTRFM-ONTUJTEPSA-N	373237	US9896452, Example 100::rac-(1-((benzo[d]oxazol-2-ylamino)methyl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone	Orexin receptor type 2	Homo sapiens		>10000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373237	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373237&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			89748230	404342339							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740983	Cc1nc(C(=O)N2C[C@H]3CCC[C@H]3C2COc2ccc(cn2)C(F)(F)F)c(s1)-c1ccc(F)cc1	InChI=1S/C25H23F4N3O2S/c1-14-31-22(23(35-14)15-5-8-18(26)9-6-15)24(33)32-12-16-3-2-4-19(16)20(32)13-34-21-10-7-17(11-30-21)25(27,28)29/h5-11,16,19-20H,2-4,12-13H2,1H3/t16-,19-,20?/m1/s1	VFLDVSFQQIENMV-YPMWCJOZSA-N	373238	US9896452, Example 101::rac-(5-(4-fluorophenyl)-2-methylthiazol-4-yl)(1-(((5-(trifluoromethyl)pyridin-2-yl)oxy)methyl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)methanone	Orexin/Hypocretin receptor type 1	Homo sapiens		 3000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373238	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373238&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89748242	404342340							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740984	Cc1nc(C(=O)N2C[C@H]3CCC[C@H]3C2COc2ccc(cn2)C(F)(F)F)c(s1)-c1ccc(F)cc1	InChI=1S/C25H23F4N3O2S/c1-14-31-22(23(35-14)15-5-8-18(26)9-6-15)24(33)32-12-16-3-2-4-19(16)20(32)13-34-21-10-7-17(11-30-21)25(27,28)29/h5-11,16,19-20H,2-4,12-13H2,1H3/t16-,19-,20?/m1/s1	VFLDVSFQQIENMV-YPMWCJOZSA-N	373238	US9896452, Example 101::rac-(5-(4-fluorophenyl)-2-methylthiazol-4-yl)(1-(((5-(trifluoromethyl)pyridin-2-yl)oxy)methyl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)methanone	Orexin receptor type 2	Homo sapiens		>10000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373238	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373238&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			89748242	404342340							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740985	Cc1nc(C(=O)N2C[C@H]3CCC[C@H]3C2COc2nc3ccccc3o2)c(s1)-c1ccc(F)cc1	InChI=1S/C26H24FN3O3S/c1-15-28-23(24(34-15)16-9-11-18(27)12-10-16)25(31)30-13-17-5-4-6-19(17)21(30)14-32-26-29-20-7-2-3-8-22(20)33-26/h2-3,7-12,17,19,21H,4-6,13-14H2,1H3/t17-,19-,21?/m1/s1	UQSGROBTFODQKD-ONTUJTEPSA-N	373239	US9896452, Example 102::rac-(1-((benzo[d]oxazol-2-yloxy)methyl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone	Orexin/Hypocretin receptor type 1	Homo sapiens		>1000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373239	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373239&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89748243	404342341							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740986	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1cc(C)ccc1-c1cnn(C)c1	InChI=1S/C25H28F3N5O/c1-16-6-8-20(18-12-31-32(3)15-18)21(11-16)24(34)33-10-4-5-17(2)22(33)14-30-23-9-7-19(13-29-23)25(26,27)28/h6-9,11-13,15,17,22H,4-5,10,14H2,1-3H3,(H,29,30)/t17-,22-/m1/s1	XHXUTIQEYCEZLE-VGOFRKELSA-N	373240	US9896452, Ex. A1::US9896452, Example 103::rac-((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(1-methyl-1H-pyrazol-4-yl)phenyl)methanone	Orexin/Hypocretin receptor type 1	Homo sapiens		 4.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373240	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373240&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89748276	404342342							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740987	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1cc(C)ccc1-c1cnn(C)c1	InChI=1S/C25H28F3N5O/c1-16-6-8-20(18-12-31-32(3)15-18)21(11-16)24(34)33-10-4-5-17(2)22(33)14-30-23-9-7-19(13-29-23)25(26,27)28/h6-9,11-13,15,17,22H,4-5,10,14H2,1-3H3,(H,29,30)/t17-,22-/m1/s1	XHXUTIQEYCEZLE-VGOFRKELSA-N	373240	US9896452, Ex. A1::US9896452, Example 103::rac-((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(1-methyl-1H-pyrazol-4-yl)phenyl)methanone	Orexin receptor type 2	Homo sapiens		 6000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373240	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373240&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			89748276	404342342							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740988	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1cc(C)ccc1-c1cccnc1	InChI=1S/C26H27F3N4O/c1-17-7-9-21(19-6-3-11-30-14-19)22(13-17)25(34)33-12-4-5-18(2)23(33)16-32-24-10-8-20(15-31-24)26(27,28)29/h3,6-11,13-15,18,23H,4-5,12,16H2,1-2H3,(H,31,32)/t18-,23-/m1/s1	YCUVBKNJESOATO-WZONZLPQSA-N	373241	US9896452, Example 104::rac-((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(pyridin-3-yl)phenyl)methanone	Orexin/Hypocretin receptor type 1	Homo sapiens		 1.000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373241	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373241&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89748277	404342343							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740989	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1cc(C)ccc1-c1cccnc1	InChI=1S/C26H27F3N4O/c1-17-7-9-21(19-6-3-11-30-14-19)22(13-17)25(34)33-12-4-5-18(2)23(33)16-32-24-10-8-20(15-31-24)26(27,28)29/h3,6-11,13-15,18,23H,4-5,12,16H2,1-2H3,(H,31,32)/t18-,23-/m1/s1	YCUVBKNJESOATO-WZONZLPQSA-N	373241	US9896452, Example 104::rac-((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(pyridin-3-yl)phenyl)methanone	Orexin receptor type 2	Homo sapiens		 8800							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373241	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373241&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			89748277	404342343							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740990	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1cc(C)ccc1-c1ccc(C)nc1	InChI=1S/C27H29F3N4O/c1-17-6-10-22(20-8-7-19(3)31-14-20)23(13-17)26(35)34-12-4-5-18(2)24(34)16-33-25-11-9-21(15-32-25)27(28,29)30/h6-11,13-15,18,24H,4-5,12,16H2,1-3H3,(H,32,33)/t18-,24-/m1/s1	DDWBXEBYOKYQKL-HOYKHHGWSA-N	373242	US9896452, Example 105::rac-((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(6-methylpyridin-3-yl)phenyl)methanone	Orexin/Hypocretin receptor type 1	Homo sapiens		 109							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373242	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373242&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89748284	404342344							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740991	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1cc(C)ccc1-c1ccc(C)nc1	InChI=1S/C27H29F3N4O/c1-17-6-10-22(20-8-7-19(3)31-14-20)23(13-17)26(35)34-12-4-5-18(2)24(34)16-33-25-11-9-21(15-32-25)27(28,29)30/h6-11,13-15,18,24H,4-5,12,16H2,1-3H3,(H,32,33)/t18-,24-/m1/s1	DDWBXEBYOKYQKL-HOYKHHGWSA-N	373242	US9896452, Example 105::rac-((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(6-methylpyridin-3-yl)phenyl)methanone	Orexin receptor type 2	Homo sapiens		 1600							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373242	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373242&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			89748284	404342344							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740992	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1cc(C)ccc1-c1ccncc1	InChI=1S/C26H27F3N4O/c1-17-5-7-21(19-9-11-30-12-10-19)22(14-17)25(34)33-13-3-4-18(2)23(33)16-32-24-8-6-20(15-31-24)26(27,28)29/h5-12,14-15,18,23H,3-4,13,16H2,1-2H3,(H,31,32)/t18-,23-/m1/s1	XDRHVSVLMFEDSY-WZONZLPQSA-N	373243	US9896452, Example 106::rac-((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(pyridin-4-yl)phenyl)methanone	Orexin/Hypocretin receptor type 1	Homo sapiens		 40.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373243	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373243&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89739622	404342345							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740993	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1cc(C)ccc1-c1ccncc1	InChI=1S/C26H27F3N4O/c1-17-5-7-21(19-9-11-30-12-10-19)22(14-17)25(34)33-13-3-4-18(2)23(33)16-32-24-8-6-20(15-31-24)26(27,28)29/h5-12,14-15,18,23H,3-4,13,16H2,1-2H3,(H,31,32)/t18-,23-/m1/s1	XDRHVSVLMFEDSY-WZONZLPQSA-N	373243	US9896452, Example 106::rac-((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(pyridin-4-yl)phenyl)methanone	Orexin receptor type 2	Homo sapiens		>1000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373243	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373243&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			89739622	404342345							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740994	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1cc(C)ccc1-c1cncnc1	InChI=1S/C25H26F3N5O/c1-16-5-7-20(18-11-29-15-30-12-18)21(10-16)24(34)33-9-3-4-17(2)22(33)14-32-23-8-6-19(13-31-23)25(26,27)28/h5-8,10-13,15,17,22H,3-4,9,14H2,1-2H3,(H,31,32)/t17-,22-/m1/s1	WEMBDXLNYKPGAQ-VGOFRKELSA-N	373244	US9896452, Example 107::rac-((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(pyrimidin-5-yl)phenyl)methanone	Orexin/Hypocretin receptor type 1	Homo sapiens		 78.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373244	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373244&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89748217	404342346							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740995	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1cc(C)ccc1-c1cncnc1	InChI=1S/C25H26F3N5O/c1-16-5-7-20(18-11-29-15-30-12-18)21(10-16)24(34)33-9-3-4-17(2)22(33)14-32-23-8-6-19(13-31-23)25(26,27)28/h5-8,10-13,15,17,22H,3-4,9,14H2,1-2H3,(H,31,32)/t17-,22-/m1/s1	WEMBDXLNYKPGAQ-VGOFRKELSA-N	373244	US9896452, Example 107::rac-((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(pyrimidin-5-yl)phenyl)methanone	Orexin receptor type 2	Homo sapiens		>10000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373244	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373244&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			89748217	404342346							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740996	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1cc(C)ccc1-c1ccnn1C	InChI=1S/C25H28F3N5O/c1-16-6-8-19(21-10-11-31-32(21)3)20(13-16)24(34)33-12-4-5-17(2)22(33)15-30-23-9-7-18(14-29-23)25(26,27)28/h6-11,13-14,17,22H,4-5,12,15H2,1-3H3,(H,29,30)/t17-,22-/m1/s1	LXNOJWWFOBQPBW-VGOFRKELSA-N	373245	US9896452, Example 108::rac-((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(1-methyl-1H-pyrazol-5-yl)phenyl)methanone	Orexin/Hypocretin receptor type 1	Homo sapiens		 13.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373245	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373245&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89748286	404342347							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740997	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1cc(C)ccc1-c1ccnn1C	InChI=1S/C25H28F3N5O/c1-16-6-8-19(21-10-11-31-32(21)3)20(13-16)24(34)33-12-4-5-17(2)22(33)15-30-23-9-7-18(14-29-23)25(26,27)28/h6-11,13-14,17,22H,4-5,12,15H2,1-3H3,(H,29,30)/t17-,22-/m1/s1	LXNOJWWFOBQPBW-VGOFRKELSA-N	373245	US9896452, Example 108::rac-((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(1-methyl-1H-pyrazol-5-yl)phenyl)methanone	Orexin receptor type 2	Homo sapiens		>10000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373245	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373245&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			89748286	404342347							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740998	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1cc(C)ccc1-c1cnc(nc1)N1CCN(C)CC1	InChI=1S/C30H36F3N7O/c1-20-6-8-24(22-16-36-29(37-17-22)39-13-11-38(3)12-14-39)25(15-20)28(41)40-10-4-5-21(2)26(40)19-35-27-9-7-23(18-34-27)30(31,32)33/h6-9,15-18,21,26H,4-5,10-14,19H2,1-3H3,(H,34,35)/t21-,26-/m1/s1	LOZZDXHXCATCLY-QFQXNSOFSA-N	373246	US9896452, Example 109::rac-((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(2-(4-methylpiperazin-1-yl)pyrimidin-5-yl)phenyl)methanone	Orexin/Hypocretin receptor type 1	Homo sapiens		>1000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373246	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373246&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89748249	404342348							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
740999	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1cc(C)ccc1-c1ccc(nc1)N1CCN(C)CC1	InChI=1S/C31H37F3N6O/c1-21-6-9-25(23-7-11-29(37-18-23)39-15-13-38(3)14-16-39)26(17-21)30(41)40-12-4-5-22(2)27(40)20-36-28-10-8-24(19-35-28)31(32,33)34/h6-11,17-19,22,27H,4-5,12-16,20H2,1-3H3,(H,35,36)/t22-,27-/m1/s1	RQCQFTQDEOESSR-AJTFRIOCSA-N	373247	US9896452, Example 110::rac-((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)phenyl)methanone	Orexin/Hypocretin receptor type 1	Homo sapiens		>1000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373247	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373247&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89748232	404342349							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741000	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1cc(C)ccc1-c1cnn(CCN2CCOCC2)c1	InChI=1S/C30H37F3N6O2/c1-21-5-7-25(23-17-36-38(20-23)11-10-37-12-14-41-15-13-37)26(16-21)29(40)39-9-3-4-22(2)27(39)19-35-28-8-6-24(18-34-28)30(31,32)33/h5-8,16-18,20,22,27H,3-4,9-15,19H2,1-2H3,(H,34,35)/t22-,27-/m1/s1	RIWNEWATGQAZCT-AJTFRIOCSA-N	373248	US9896452, Example 111::rac-((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(1-(2-morpholinoethyl)-1H-pyrazol-4-yl)phenyl)methanone	Orexin/Hypocretin receptor type 1	Homo sapiens		>1000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373248	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373248&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89748272	404342350							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741001	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1cc(C)ccc1-c1ncccn1	InChI=1S/C25H26F3N5O/c1-16-6-8-19(23-29-10-4-11-30-23)20(13-16)24(34)33-12-3-5-17(2)21(33)15-32-22-9-7-18(14-31-22)25(26,27)28/h4,6-11,13-14,17,21H,3,5,12,15H2,1-2H3,(H,31,32)/t17-,21-/m1/s1	XWIPXBDSBZAUCQ-DYESRHJHSA-N	373249	US9896452, Example 112::rac-((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(pyrimidin-2-yl)phenyl)methanone	Orexin/Hypocretin receptor type 1	Homo sapiens		 17.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373249	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373249&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89748233	404342351							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741002	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1cc(C)ccc1-c1ncccn1	InChI=1S/C25H26F3N5O/c1-16-6-8-19(23-29-10-4-11-30-23)20(13-16)24(34)33-12-3-5-17(2)21(33)15-32-22-9-7-18(14-31-22)25(26,27)28/h4,6-11,13-14,17,21H,3,5,12,15H2,1-2H3,(H,31,32)/t17-,21-/m1/s1	XWIPXBDSBZAUCQ-DYESRHJHSA-N	373249	US9896452, Example 112::rac-((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(pyrimidin-2-yl)phenyl)methanone	Orexin receptor type 2	Homo sapiens		>10000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373249	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373249&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			89748233	404342351							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741003	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1cc(C)ccc1-c1ncco1	InChI=1S/C24H25F3N4O2/c1-15-5-7-18(22-28-9-11-33-22)19(12-15)23(32)31-10-3-4-16(2)20(31)14-30-21-8-6-17(13-29-21)24(25,26)27/h5-9,11-13,16,20H,3-4,10,14H2,1-2H3,(H,29,30)/t16-,20-/m1/s1	BRMBXQLTVLGCMF-OXQOHEQNSA-N	373250	US9896452, Example 113::rac-((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(oxazol-2-yl)phenyl)methanone	Orexin/Hypocretin receptor type 1	Homo sapiens		 25.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373250	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373250&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89739343	404342352							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741004	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1cc(C)ccc1-c1ncco1	InChI=1S/C24H25F3N4O2/c1-15-5-7-18(22-28-9-11-33-22)19(12-15)23(32)31-10-3-4-16(2)20(31)14-30-21-8-6-17(13-29-21)24(25,26)27/h5-9,11-13,16,20H,3-4,10,14H2,1-2H3,(H,29,30)/t16-,20-/m1/s1	BRMBXQLTVLGCMF-OXQOHEQNSA-N	373250	US9896452, Example 113::rac-((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(oxazol-2-yl)phenyl)methanone	Orexin receptor type 2	Homo sapiens		 190							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373250	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373250&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			89739343	404342352							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741005	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1cc(C)ccc1-n1nccn1	InChI=1S/C23H25F3N6O/c1-15-5-7-19(32-29-9-10-30-32)18(12-15)22(33)31-11-3-4-16(2)20(31)14-28-21-8-6-17(13-27-21)23(24,25)26/h5-10,12-13,16,20H,3-4,11,14H2,1-2H3,(H,27,28)/t16-,20-/m1/s1	KTHFQWHOCBTIND-OXQOHEQNSA-N	373251	US9896452, Ex. A106::US9896452, Example 114::rac-((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone	Orexin/Hypocretin receptor type 1	Homo sapiens		 3.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373251	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373251&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89748160	404342353							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741006	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1cc(C)ccc1-n1nccn1	InChI=1S/C23H25F3N6O/c1-15-5-7-19(32-29-9-10-30-32)18(12-15)22(33)31-11-3-4-16(2)20(31)14-28-21-8-6-17(13-27-21)23(24,25)26/h5-10,12-13,16,20H,3-4,11,14H2,1-2H3,(H,27,28)/t16-,20-/m1/s1	KTHFQWHOCBTIND-OXQOHEQNSA-N	373251	US9896452, Ex. A106::US9896452, Example 114::rac-((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone	Orexin receptor type 2	Homo sapiens		>10000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373251	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373251&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			89748160	404342353							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741007	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1cc(C)ccc1-n1ccnn1	InChI=1S/C23H25F3N6O/c1-15-5-7-19(32-11-9-29-30-32)18(12-15)22(33)31-10-3-4-16(2)20(31)14-28-21-8-6-17(13-27-21)23(24,25)26/h5-9,11-13,16,20H,3-4,10,14H2,1-2H3,(H,27,28)/t16-,20-/m1/s1	ZEKZASNCWSHDED-OXQOHEQNSA-N	373252	US9896452, Example 115::rac-((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(1H-1,2,3-triazol-1-yl)phenyl)methanone	Orexin/Hypocretin receptor type 1	Homo sapiens		 10.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373252	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373252&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89748163	404342354							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741008	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1cc(C)ccc1-n1ccnn1	InChI=1S/C23H25F3N6O/c1-15-5-7-19(32-11-9-29-30-32)18(12-15)22(33)31-10-3-4-16(2)20(31)14-28-21-8-6-17(13-27-21)23(24,25)26/h5-9,11-13,16,20H,3-4,10,14H2,1-2H3,(H,27,28)/t16-,20-/m1/s1	ZEKZASNCWSHDED-OXQOHEQNSA-N	373252	US9896452, Example 115::rac-((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(1H-1,2,3-triazol-1-yl)phenyl)methanone	Orexin receptor type 2	Homo sapiens		>10000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373252	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373252&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			89748163	404342354							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741009	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1cc(C)ccc1-n1ccnc1	InChI=1S/C24H26F3N5O/c1-16-5-7-20(31-11-9-28-15-31)19(12-16)23(33)32-10-3-4-17(2)21(32)14-30-22-8-6-18(13-29-22)24(25,26)27/h5-9,11-13,15,17,21H,3-4,10,14H2,1-2H3,(H,29,30)/t17-,21-/m1/s1	ISBJYSUXQMDRBI-DYESRHJHSA-N	373253	US9896452, Example 116::rac-(2-(1H-imidazol-1-yl)-5-methylphenyl)((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)methanone	Orexin/Hypocretin receptor type 1	Homo sapiens		<100.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373253	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373253&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89748177	404342355							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741010	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1cc(C)ccc1-n1cncn1	InChI=1S/C23H25F3N6O/c1-15-5-7-19(32-14-27-13-30-32)18(10-15)22(33)31-9-3-4-16(2)20(31)12-29-21-8-6-17(11-28-21)23(24,25)26/h5-8,10-11,13-14,16,20H,3-4,9,12H2,1-2H3,(H,28,29)/t16-,20-/m1/s1	YQOULNXVZPMRHL-OXQOHEQNSA-N	373254	US9896452, Example 117::rac-((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(1H-1,2,4-triazol-1-yl)phenyl)methanone	Orexin/Hypocretin receptor type 1	Homo sapiens		 38.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373254	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373254&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89748164	404342356							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741011	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1cc(C)ccc1-n1cncn1	InChI=1S/C23H25F3N6O/c1-15-5-7-19(32-14-27-13-30-32)18(10-15)22(33)31-9-3-4-16(2)20(31)12-29-21-8-6-17(11-28-21)23(24,25)26/h5-8,10-11,13-14,16,20H,3-4,9,12H2,1-2H3,(H,28,29)/t16-,20-/m1/s1	YQOULNXVZPMRHL-OXQOHEQNSA-N	373254	US9896452, Example 117::rac-((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(1H-1,2,4-triazol-1-yl)phenyl)methanone	Orexin receptor type 2	Homo sapiens		>10000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373254	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373254&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			89748164	404342356							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741012	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1ccccc1Oc1ccccc1	InChI=1S/C26H26F3N3O2/c1-18-8-7-15-32(22(18)17-31-24-14-13-19(16-30-24)26(27,28)29)25(33)21-11-5-6-12-23(21)34-20-9-3-2-4-10-20/h2-6,9-14,16,18,22H,7-8,15,17H2,1H3,(H,30,31)/t18-,22-/m1/s1	NLGJRSVKPYNZGD-XMSQKQJNSA-N	373255	US9896452, Example 118::rac-((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(2-phenoxyphenyl)methanone	Orexin/Hypocretin receptor type 1	Homo sapiens		 262							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373255	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373255&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89748166	404342357							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741013	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1ccccc1Oc1ccccc1	InChI=1S/C26H26F3N3O2/c1-18-8-7-15-32(22(18)17-31-24-14-13-19(16-30-24)26(27,28)29)25(33)21-11-5-6-12-23(21)34-20-9-3-2-4-10-20/h2-6,9-14,16,18,22H,7-8,15,17H2,1H3,(H,30,31)/t18-,22-/m1/s1	NLGJRSVKPYNZGD-XMSQKQJNSA-N	373255	US9896452, Example 118::rac-((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(2-phenoxyphenyl)methanone	Orexin receptor type 2	Homo sapiens		>10000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373255	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373255&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			89748166	404342357							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741014	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1ccnn1-c1ccccc1	InChI=1S/C23H24F3N5O/c1-16-6-5-13-30(20(16)15-28-21-10-9-17(14-27-21)23(24,25)26)22(32)19-11-12-29-31(19)18-7-3-2-4-8-18/h2-4,7-12,14,16,20H,5-6,13,15H2,1H3,(H,27,28)/t16-,20-/m1/s1	NUXVQZDISSPOCV-OXQOHEQNSA-N	373256	US9896452, Example 119::rac-((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(1-phenyl-1H-pyrazol-5-yl)methanone	Orexin/Hypocretin receptor type 1	Homo sapiens		 400							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373256	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373256&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89740521	404342358							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741015	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1ccnn1-c1ccccc1	InChI=1S/C23H24F3N5O/c1-16-6-5-13-30(20(16)15-28-21-10-9-17(14-27-21)23(24,25)26)22(32)19-11-12-29-31(19)18-7-3-2-4-8-18/h2-4,7-12,14,16,20H,5-6,13,15H2,1H3,(H,27,28)/t16-,20-/m1/s1	NUXVQZDISSPOCV-OXQOHEQNSA-N	373256	US9896452, Example 119::rac-((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(1-phenyl-1H-pyrazol-5-yl)methanone	Orexin receptor type 2	Homo sapiens		>10000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373256	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373256&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			89740521	404342358							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741016	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1ccccc1-n1nccn1	InChI=1S/C22H23F3N6O/c1-15-5-4-12-30(19(15)14-27-20-9-8-16(13-26-20)22(23,24)25)21(32)17-6-2-3-7-18(17)31-28-10-11-29-31/h2-3,6-11,13,15,19H,4-5,12,14H2,1H3,(H,26,27)/t15-,19-/m1/s1	FCVLRNRCGDIIDA-DNVCBOLYSA-N	373257	US9896452, Ex. A314::US9896452, Example 120::rac-((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(1H-pyrazol-1-yl)phenyl)methanone	Orexin/Hypocretin receptor type 1	Homo sapiens		 3.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373257	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373257&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728107	404342359							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741017	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1ccccc1-n1nccn1	InChI=1S/C22H23F3N6O/c1-15-5-4-12-30(19(15)14-27-20-9-8-16(13-26-20)22(23,24)25)21(32)17-6-2-3-7-18(17)31-28-10-11-29-31/h2-3,6-11,13,15,19H,4-5,12,14H2,1H3,(H,26,27)/t15-,19-/m1/s1	FCVLRNRCGDIIDA-DNVCBOLYSA-N	373257	US9896452, Ex. A314::US9896452, Example 120::rac-((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(1H-pyrazol-1-yl)phenyl)methanone	Orexin receptor type 2	Homo sapiens		 500							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373257	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373257&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117728107	404342359							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741018	C[C@@H]1CCCN([C@@H]1CNc1nccnc1Cl)C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C22H23ClFN5OS/c1-13-4-3-11-29(17(13)12-27-21-20(23)25-9-10-26-21)22(30)18-19(31-14(2)28-18)15-5-7-16(24)8-6-15/h5-10,13,17H,3-4,11-12H2,1-2H3,(H,26,27)/t13-,17-/m1/s1	WUPSIVBFXUPBBZ-CXAGYDPISA-N	373258	US9896452, Example 121::rac-((2S,3R)-2-(((3-chloropyrazin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone	Orexin/Hypocretin receptor type 1	Homo sapiens		>1000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373258	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373258&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89739533	404342360							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741019	C[C@@H]1CCCN([C@@H]1CNc1ncc(Cl)cn1)C(=O)c1ccccc1OC(F)(F)F	InChI=1S/C19H20ClF3N4O2/c1-12-5-4-8-27(15(12)11-26-18-24-9-13(20)10-25-18)17(28)14-6-2-3-7-16(14)29-19(21,22)23/h2-3,6-7,9-10,12,15H,4-5,8,11H2,1H3,(H,24,25,26)/t12-,15-/m1/s1	GXEVWILUXKAVKS-IUODEOHRSA-N	373259	US9896452, Example 122::rac-((2S,3R)-2-(((5-chloropyrimidin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(2-(trifluoromethoxy)phenyl)methanone	Orexin/Hypocretin receptor type 1	Homo sapiens		 3500							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373259	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373259&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89748178	404342361							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741020	C[C@@H]1CCCN([C@@H]1CNc1ncc(Cl)cn1)C(=O)c1ccccc1OC(F)(F)F	InChI=1S/C19H20ClF3N4O2/c1-12-5-4-8-27(15(12)11-26-18-24-9-13(20)10-25-18)17(28)14-6-2-3-7-16(14)29-19(21,22)23/h2-3,6-7,9-10,12,15H,4-5,8,11H2,1H3,(H,24,25,26)/t12-,15-/m1/s1	GXEVWILUXKAVKS-IUODEOHRSA-N	373259	US9896452, Example 122::rac-((2S,3R)-2-(((5-chloropyrimidin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(2-(trifluoromethoxy)phenyl)methanone	Orexin receptor type 2	Homo sapiens		 5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373259	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373259&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			89748178	404342361							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741021	C[C@@H]1CCCN([C@@H]1CNc1cncc(Cl)n1)C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C22H23ClFN5OS/c1-13-4-3-9-29(17(13)10-26-19-12-25-11-18(23)28-19)22(30)20-21(31-14(2)27-20)15-5-7-16(24)8-6-15/h5-8,11-13,17H,3-4,9-10H2,1-2H3,(H,26,28)/t13-,17-/m1/s1	UJDJPPZVYSNBKU-CXAGYDPISA-N	373260	US9896452, Example 123::rac-((2S,3R)-2-(((6-chloropyrazin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone	Orexin/Hypocretin receptor type 1	Homo sapiens		 3600							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373260	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373260&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89739813	404342362							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741022	C[C@@H]1CCCN([C@@H]1CNc1cncc(Cl)n1)C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C22H23ClFN5OS/c1-13-4-3-9-29(17(13)10-26-19-12-25-11-18(23)28-19)22(30)20-21(31-14(2)27-20)15-5-7-16(24)8-6-15/h5-8,11-13,17H,3-4,9-10H2,1-2H3,(H,26,28)/t13-,17-/m1/s1	UJDJPPZVYSNBKU-CXAGYDPISA-N	373260	US9896452, Example 123::rac-((2S,3R)-2-(((6-chloropyrazin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone	Orexin receptor type 2	Homo sapiens		 3200							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373260	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373260&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			89739813	404342362							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741023	C[C@@H]1CCCN([C@@H]1CNC(=O)c1cccc2oc(C)cc12)C(=O)c1nc(C)sc1-c1ccccc1	InChI=1S/C28H29N3O3S/c1-17-9-8-14-31(28(33)25-26(35-19(3)30-25)20-10-5-4-6-11-20)23(17)16-29-27(32)21-12-7-13-24-22(21)15-18(2)34-24/h4-7,10-13,15,17,23H,8-9,14,16H2,1-3H3,(H,29,32)/t17-,23-/m1/s1	VLBRCICIJFGSAX-UZUQRXQVSA-N	50384424	CHEMBL2031486::US9896452, Example 124	Orexin/Hypocretin receptor type 1	Homo sapiens		 15.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50384424	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50384424&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			70685886	160863507		CHEMBL2031486				ZINC84759398	1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741024	C[C@@H]1CCCN([C@@H]1CNC(=O)c1cccc2oc(C)cc12)C(=O)c1nc(C)sc1-c1ccccc1	InChI=1S/C28H29N3O3S/c1-17-9-8-14-31(28(33)25-26(35-19(3)30-25)20-10-5-4-6-11-20)23(17)16-29-27(32)21-12-7-13-24-22(21)15-18(2)34-24/h4-7,10-13,15,17,23H,8-9,14,16H2,1-3H3,(H,29,32)/t17-,23-/m1/s1	VLBRCICIJFGSAX-UZUQRXQVSA-N	50384424	CHEMBL2031486::US9896452, Example 124	Orexin receptor type 2	Homo sapiens		 237							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50384424	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50384424&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			70685886	160863507		CHEMBL2031486				ZINC84759398	1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741025	C[C@@H]1CCCN([C@@H]1CNC(=O)c1cccc2cccnc12)C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C28H27FN4O2S/c1-17-6-5-15-33(28(35)25-26(36-18(2)32-25)20-10-12-21(29)13-11-20)23(17)16-31-27(34)22-9-3-7-19-8-4-14-30-24(19)22/h3-4,7-14,17,23H,5-6,15-16H2,1-2H3,(H,31,34)/t17-,23-/m1/s1	AIQBJVPTNVSUNF-UZUQRXQVSA-N	50384422	CHEMBL2031484::US9896452, Example 125	Orexin/Hypocretin receptor type 1	Homo sapiens		 10.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50384422	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50384422&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			70681619	160863505		CHEMBL2031484				ZINC84652893	1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741026	C[C@@H]1CCCN([C@@H]1CNC(=O)c1cccc2cccnc12)C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C28H27FN4O2S/c1-17-6-5-15-33(28(35)25-26(36-18(2)32-25)20-10-12-21(29)13-11-20)23(17)16-31-27(34)22-9-3-7-19-8-4-14-30-24(19)22/h3-4,7-14,17,23H,5-6,15-16H2,1-2H3,(H,31,34)/t17-,23-/m1/s1	AIQBJVPTNVSUNF-UZUQRXQVSA-N	50384422	CHEMBL2031484::US9896452, Example 125	Orexin receptor type 2	Homo sapiens		 95.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50384422	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50384422&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			70681619	160863505		CHEMBL2031484				ZINC84652893	1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741027	O[C@H]1C[C@@H](CNC(=O)c2cccc3cccnc23)N(C1)C(=O)c1ccccc1-c1ccccc1	InChI=1S/C28H25N3O3/c32-22-16-21(17-30-27(33)25-14-6-10-20-11-7-15-29-26(20)25)31(18-22)28(34)24-13-5-4-12-23(24)19-8-2-1-3-9-19/h1-15,21-22,32H,16-18H2,(H,30,33)/t21-,22-/m0/s1	DGPPIHXUBWXOKZ-VXKWHMMOSA-N	373263	N-(((2S,4S)-1-([1,1&#8242;-biphenyl]-2-carbonyl)-4-hydroxypyrrolidin-2-yl)methyl)quinoline-8-carboxamide::US9896452, Example 126	Orexin/Hypocretin receptor type 1	Homo sapiens		 6.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373263	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373263&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89748180	404342365							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741028	O[C@H]1C[C@@H](CNC(=O)c2cccc3cccnc23)N(C1)C(=O)c1ccccc1-c1ccccc1	InChI=1S/C28H25N3O3/c32-22-16-21(17-30-27(33)25-14-6-10-20-11-7-15-29-26(20)25)31(18-22)28(34)24-13-5-4-12-23(24)19-8-2-1-3-9-19/h1-15,21-22,32H,16-18H2,(H,30,33)/t21-,22-/m0/s1	DGPPIHXUBWXOKZ-VXKWHMMOSA-N	373263	N-(((2S,4S)-1-([1,1&#8242;-biphenyl]-2-carbonyl)-4-hydroxypyrrolidin-2-yl)methyl)quinoline-8-carboxamide::US9896452, Example 126	Orexin receptor type 2	Homo sapiens		 8.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373263	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373263&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			89748180	404342365							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741029	CO[C@H]1C[C@@H](CNC(=O)c2cccc3cccnc23)N(C1)C(=O)c1ccccc1-c1ccccc1	InChI=1S/C29H27N3O3/c1-35-23-17-22(18-31-28(33)26-15-7-11-21-12-8-16-30-27(21)26)32(19-23)29(34)25-14-6-5-13-24(25)20-9-3-2-4-10-20/h2-16,22-23H,17-19H2,1H3,(H,31,33)/t22-,23-/m0/s1	LCUULBNNTBGAPD-GOTSBHOMSA-N	373264	N-(((2S,4S)-1-([1,1&#8242;-biphenyl]-2-carbonyl)-4-methoxypyrrolidin-2-yl)methyl)quinoline-8-carboxamide::US9896452, Example 127	Orexin/Hypocretin receptor type 1	Homo sapiens		 8.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373264	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373264&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89748168	404342366							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741030	CO[C@H]1C[C@@H](CNC(=O)c2cccc3cccnc23)N(C1)C(=O)c1ccccc1-c1ccccc1	InChI=1S/C29H27N3O3/c1-35-23-17-22(18-31-28(33)26-15-7-11-21-12-8-16-30-27(21)26)32(19-23)29(34)25-14-6-5-13-24(25)20-9-3-2-4-10-20/h2-16,22-23H,17-19H2,1H3,(H,31,33)/t22-,23-/m0/s1	LCUULBNNTBGAPD-GOTSBHOMSA-N	373264	N-(((2S,4S)-1-([1,1&#8242;-biphenyl]-2-carbonyl)-4-methoxypyrrolidin-2-yl)methyl)quinoline-8-carboxamide::US9896452, Example 127	Orexin receptor type 2	Homo sapiens		 25.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373264	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373264&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			89748168	404342366							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741031	F[C@@H]1C[C@@H](CNC(=O)c2cccc3cccnc23)N(C1)C(=O)c1ccccc1-c1ccccc1	InChI=1S/C28H24FN3O2/c29-21-16-22(17-31-27(33)25-14-6-10-20-11-7-15-30-26(20)25)32(18-21)28(34)24-13-5-4-12-23(24)19-8-2-1-3-9-19/h1-15,21-22H,16-18H2,(H,31,33)/t21-,22+/m1/s1	QTPNZRYZZTWQMZ-YADHBBJMSA-N	373265	N-(((2S,4R)-1-(Biphenylcarbonyl)-4-fluoropyrrolidin-2-yl)methyl)quinoline-8-carboxamide::US9896452, Example 128	Orexin/Hypocretin receptor type 1	Homo sapiens		 35.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373265	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373265&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89748169	404342367							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741032	F[C@@H]1C[C@@H](CNC(=O)c2cccc3cccnc23)N(C1)C(=O)c1ccccc1-c1ccccc1	InChI=1S/C28H24FN3O2/c29-21-16-22(17-31-27(33)25-14-6-10-20-11-7-15-30-26(20)25)32(18-21)28(34)24-13-5-4-12-23(24)19-8-2-1-3-9-19/h1-15,21-22H,16-18H2,(H,31,33)/t21-,22+/m1/s1	QTPNZRYZZTWQMZ-YADHBBJMSA-N	373265	N-(((2S,4R)-1-(Biphenylcarbonyl)-4-fluoropyrrolidin-2-yl)methyl)quinoline-8-carboxamide::US9896452, Example 128	Orexin receptor type 2	Homo sapiens		 30.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373265	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373265&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			89748169	404342367							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741033	CO[C@@H]1C[C@@H](CNC(=O)c2cccc3cccnc23)N(C1)C(=O)c1ccccc1-c1ccccc1	InChI=1S/C29H27N3O3/c1-35-23-17-22(18-31-28(33)26-15-7-11-21-12-8-16-30-27(21)26)32(19-23)29(34)25-14-6-5-13-24(25)20-9-3-2-4-10-20/h2-16,22-23H,17-19H2,1H3,(H,31,33)/t22-,23+/m0/s1	LCUULBNNTBGAPD-XZOQPEGZSA-N	373266	N-(((2S,4R)-1-([1,1&#8242;-biphenyl]-2-carbonyl)-4-methoxypyrrolidin-2-yl)methyl)quinoline-8-carboxamide::US9896452, Example 129	Orexin/Hypocretin receptor type 1	Homo sapiens		 120							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373266	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373266&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89748170	404342368							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741034	CO[C@@H]1C[C@@H](CNC(=O)c2cccc3cccnc23)N(C1)C(=O)c1ccccc1-c1ccccc1	InChI=1S/C29H27N3O3/c1-35-23-17-22(18-31-28(33)26-15-7-11-21-12-8-16-30-27(21)26)32(19-23)29(34)25-14-6-5-13-24(25)20-9-3-2-4-10-20/h2-16,22-23H,17-19H2,1H3,(H,31,33)/t22-,23+/m0/s1	LCUULBNNTBGAPD-XZOQPEGZSA-N	373266	N-(((2S,4R)-1-([1,1&#8242;-biphenyl]-2-carbonyl)-4-methoxypyrrolidin-2-yl)methyl)quinoline-8-carboxamide::US9896452, Example 129	Orexin receptor type 2	Homo sapiens		 320							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373266	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373266&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			89748170	404342368							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741035	Cc1nc(c(s1)C(=O)N1CC[C@H](O)[C@H]1CNC(=O)c1cccc2cccnc12)-c1ccccc1	InChI=1S/C26H24N4O3S/c1-16-29-23(18-7-3-2-4-8-18)24(34-16)26(33)30-14-12-21(31)20(30)15-28-25(32)19-11-5-9-17-10-6-13-27-22(17)19/h2-11,13,20-21,31H,12,14-15H2,1H3,(H,28,32)/t20-,21+/m1/s1	FGLKLNBPUKOQPH-RTWAWAEBSA-N	373267	N-(((2R,3S)-3-hydroxy-1-(2-methyl-4-phenylthiazole-5-carbonyl)pyrrolidin-2-yl)methyl)quinoline-8-carboxamide::US9896452, Example 130	Orexin/Hypocretin receptor type 1	Homo sapiens		 6.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373267	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373267&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89748179	404342369							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741036	CC(=O)O[C@H]1C[C@@H](CNC(=O)c2cccc3cccnc23)N(C1)C(=O)c1ccccc1-c1ccccc1	InChI=1S/C30H27N3O4/c1-20(34)37-24-17-23(18-32-29(35)27-15-7-11-22-12-8-16-31-28(22)27)33(19-24)30(36)26-14-6-5-13-25(26)21-9-3-2-4-10-21/h2-16,23-24H,17-19H2,1H3,(H,32,35)/t23-,24-/m0/s1	UNSBHHWFPLXPNB-ZEQRLZLVSA-N	373268	(3S,5S)-1-([1,1&#8242;-biphenyl]-2-carbonyl)-5-((quinoline-8-carboxamido)methyl)pyrrolidin-3-yl acetate::US9896452, Example 131	Orexin/Hypocretin receptor type 1	Homo sapiens		 53.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373268	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373268&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			71715847	404342370							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741037	CC(=O)O[C@H]1C[C@@H](CNC(=O)c2cccc3cccnc23)N(C1)C(=O)c1ccccc1-c1ccccc1	InChI=1S/C30H27N3O4/c1-20(34)37-24-17-23(18-32-29(35)27-15-7-11-22-12-8-16-31-28(22)27)33(19-24)30(36)26-14-6-5-13-25(26)21-9-3-2-4-10-21/h2-16,23-24H,17-19H2,1H3,(H,32,35)/t23-,24-/m0/s1	UNSBHHWFPLXPNB-ZEQRLZLVSA-N	373268	(3S,5S)-1-([1,1&#8242;-biphenyl]-2-carbonyl)-5-((quinoline-8-carboxamido)methyl)pyrrolidin-3-yl acetate::US9896452, Example 131	Orexin receptor type 2	Homo sapiens		 40.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373268	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373268&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			71715847	404342370							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741038	Cc1nc(c(s1)C(=O)N1CCC(=O)[C@H]1CNC(=O)c1cccc2cccnc12)-c1ccccc1	InChI=1S/C26H22N4O3S/c1-16-29-23(18-7-3-2-4-8-18)24(34-16)26(33)30-14-12-21(31)20(30)15-28-25(32)19-11-5-9-17-10-6-13-27-22(17)19/h2-11,13,20H,12,14-15H2,1H3,(H,28,32)/t20-/m1/s1	VTUBYRUKBJKXRZ-HXUWFJFHSA-N	373269	(R)-N-((1-(2-methyl-4-phenylthiazole-5-carbonyl)-3-oxopyrrolidin-2-yl)methyl)quinoline-8-carboxamide::US9896452, Example 132	Orexin/Hypocretin receptor type 1	Homo sapiens		 230							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373269	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373269&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89739187	404342371							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741039	Cc1nc(c(s1)C(=O)N1CCC(=O)[C@H]1CNC(=O)c1cccc2cccnc12)-c1ccccc1	InChI=1S/C26H22N4O3S/c1-16-29-23(18-7-3-2-4-8-18)24(34-16)26(33)30-14-12-21(31)20(30)15-28-25(32)19-11-5-9-17-10-6-13-27-22(17)19/h2-11,13,20H,12,14-15H2,1H3,(H,28,32)/t20-/m1/s1	VTUBYRUKBJKXRZ-HXUWFJFHSA-N	373269	(R)-N-((1-(2-methyl-4-phenylthiazole-5-carbonyl)-3-oxopyrrolidin-2-yl)methyl)quinoline-8-carboxamide::US9896452, Example 132	Orexin receptor type 2	Homo sapiens		 1400							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373269	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373269&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			89739187	404342371							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741040	Cc1nc(c(s1)C(=O)N1CCC(F)(F)[C@H]1CNC(=O)c1cccc2cccnc12)-c1ccccc1	InChI=1S/C26H22F2N4O2S/c1-16-31-22(18-7-3-2-4-8-18)23(35-16)25(34)32-14-12-26(27,28)20(32)15-30-24(33)19-11-5-9-17-10-6-13-29-21(17)19/h2-11,13,20H,12,14-15H2,1H3,(H,30,33)/t20-/m1/s1	RWAAIAZKYDLWDY-HXUWFJFHSA-N	373270	(R)-N-((3,3-difluoro-1-(2-methyl-4-phenylthiazole-5-carbonyl)pyrrolidin-2-yl)methyl)quinoline-8-carboxamide::US9896452, Example 133	Orexin/Hypocretin receptor type 1	Homo sapiens		 12.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373270	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373270&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89739525	404342372							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741041	Cc1nc(c(s1)C(=O)N1CCC(F)(F)[C@H]1CNC(=O)c1cccc2cccnc12)-c1ccccc1	InChI=1S/C26H22F2N4O2S/c1-16-31-22(18-7-3-2-4-8-18)23(35-16)25(34)32-14-12-26(27,28)20(32)15-30-24(33)19-11-5-9-17-10-6-13-29-21(17)19/h2-11,13,20H,12,14-15H2,1H3,(H,30,33)/t20-/m1/s1	RWAAIAZKYDLWDY-HXUWFJFHSA-N	373270	(R)-N-((3,3-difluoro-1-(2-methyl-4-phenylthiazole-5-carbonyl)pyrrolidin-2-yl)methyl)quinoline-8-carboxamide::US9896452, Example 133	Orexin receptor type 2	Homo sapiens		 1400							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373270	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373270&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			89739525	404342372							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741042	Cc1nc(c(s1)C(=O)N1CC[C@@H](O)C[C@H]1CNC(=O)c1cccc2cccnc12)-c1ccccc1	InChI=1S/C27H26N4O3S/c1-17-30-24(19-7-3-2-4-8-19)25(35-17)27(34)31-14-12-21(32)15-20(31)16-29-26(33)22-11-5-9-18-10-6-13-28-23(18)22/h2-11,13,20-21,32H,12,14-16H2,1H3,(H,29,33)/t20-,21+/m0/s1	OAWDJSBCYTYARA-LEWJYISDSA-N	373271	N-(((2S,4R)-4-hydroxy-1-(2-methyl-4-phenylthiazole-5-carbonyl)piperidin-2-yl)methyl)quinoline-8-carboxamide::US9896452, Example 134	Orexin/Hypocretin receptor type 1	Homo sapiens		 5.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373271	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373271&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89740379	404342373							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741043	Cc1nc(c(s1)C(=O)N1CC[C@@H](O)C[C@H]1CNC(=O)c1cccc2cccnc12)-c1ccccc1	InChI=1S/C27H26N4O3S/c1-17-30-24(19-7-3-2-4-8-19)25(35-17)27(34)31-14-12-21(32)15-20(31)16-29-26(33)22-11-5-9-18-10-6-13-28-23(18)22/h2-11,13,20-21,32H,12,14-16H2,1H3,(H,29,33)/t20-,21+/m0/s1	OAWDJSBCYTYARA-LEWJYISDSA-N	373271	N-(((2S,4R)-4-hydroxy-1-(2-methyl-4-phenylthiazole-5-carbonyl)piperidin-2-yl)methyl)quinoline-8-carboxamide::US9896452, Example 134	Orexin receptor type 2	Homo sapiens		>10000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373271	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373271&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			89740379	404342373							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741044	Cc1nc(c(s1)C(=O)N1CCC(F)(F)C[C@H]1CNC(=O)c1cccc2cccnc12)-c1ccccc1	InChI=1S/C27H24F2N4O2S/c1-17-32-23(19-7-3-2-4-8-19)24(36-17)26(35)33-14-12-27(28,29)15-20(33)16-31-25(34)21-11-5-9-18-10-6-13-30-22(18)21/h2-11,13,20H,12,14-16H2,1H3,(H,31,34)/t20-/m0/s1	PBDFCTXWCIUFCB-FQEVSTJZSA-N	50384433	CHEMBL2031496::US9896452, Example 136	Orexin/Hypocretin receptor type 1	Homo sapiens		<1000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50384433	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50384433&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			70683743	160863516		CHEMBL2031496				ZINC84669966	1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741045	C[C@H]1CCCN([C@@H]1CNC(=O)c1cccc2cccnc12)C(=O)c1nc(C)sc1-c1ccccc1	InChI=1S/C28H28N4O2S/c1-18-9-8-16-32(28(34)25-26(35-19(2)31-25)21-10-4-3-5-11-21)23(18)17-30-27(33)22-14-6-12-20-13-7-15-29-24(20)22/h3-7,10-15,18,23H,8-9,16-17H2,1-2H3,(H,30,33)/t18-,23+/m0/s1	SRKVUFVTSRBFFN-FDDCHVKYSA-N	50384429	CHEMBL2031492::US9896452, Example 137	Orexin/Hypocretin receptor type 1	Homo sapiens		 3.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50384429	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50384429&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			70694255	160863512		CHEMBL2031492				ZINC84668471	1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741046	C[C@H]1CCCN([C@@H]1CNC(=O)c1cccc2cccnc12)C(=O)c1nc(C)sc1-c1ccccc1	InChI=1S/C28H28N4O2S/c1-18-9-8-16-32(28(34)25-26(35-19(2)31-25)21-10-4-3-5-11-21)23(18)17-30-27(33)22-14-6-12-20-13-7-15-29-24(20)22/h3-7,10-15,18,23H,8-9,16-17H2,1-2H3,(H,30,33)/t18-,23+/m0/s1	SRKVUFVTSRBFFN-FDDCHVKYSA-N	50384429	CHEMBL2031492::US9896452, Example 137	Orexin receptor type 2	Homo sapiens		 100.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50384429	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50384429&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			70694255	160863512		CHEMBL2031492				ZINC84668471	1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741047	Cc1nc(C(=O)N2CCC[C@H]([C@H]2CNC(=O)c2cccc3cccnc23)C(F)(F)F)c(s1)-c1ccccc1	InChI=1S/C28H25F3N4O2S/c1-17-34-24(25(38-17)19-8-3-2-4-9-19)27(37)35-15-7-13-21(28(29,30)31)22(35)16-33-26(36)20-12-5-10-18-11-6-14-32-23(18)20/h2-6,8-12,14,21-22H,7,13,15-16H2,1H3,(H,33,36)/t21-,22-/m1/s1	JZHYQAVNBVKWNS-FGZHOGPDSA-N	50384409	CHEMBL2031487::US9896452, Example 138	Orexin/Hypocretin receptor type 1	Homo sapiens		 8.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50384409	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50384409&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			70688011	160863492		CHEMBL2031487				ZINC84759399	1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741048	Cc1nc(C(=O)N2CCC[C@H]([C@H]2CNC(=O)c2cccc3cccnc23)C(F)(F)F)c(s1)-c1ccccc1	InChI=1S/C28H25F3N4O2S/c1-17-34-24(25(38-17)19-8-3-2-4-9-19)27(37)35-15-7-13-21(28(29,30)31)22(35)16-33-26(36)20-12-5-10-18-11-6-14-32-23(18)20/h2-6,8-12,14,21-22H,7,13,15-16H2,1H3,(H,33,36)/t21-,22-/m1/s1	JZHYQAVNBVKWNS-FGZHOGPDSA-N	50384409	CHEMBL2031487::US9896452, Example 138	Orexin receptor type 2	Homo sapiens		 40.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50384409	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50384409&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			70688011	160863492		CHEMBL2031487				ZINC84759399	1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741049	Cc1nc(C(=O)N2CCC[C@H]([C@H]2CNC(=O)c2cccc3occc23)C(F)(F)F)c(s1)-c1ccccc1	InChI=1S/C27H24F3N3O3S/c1-16-32-23(24(37-16)17-7-3-2-4-8-17)26(35)33-13-6-10-20(27(28,29)30)21(33)15-31-25(34)19-9-5-11-22-18(19)12-14-36-22/h2-5,7-9,11-12,14,20-21H,6,10,13,15H2,1H3,(H,31,34)/t20-,21-/m1/s1	LHCWXNBUYBMDHF-NHCUHLMSSA-N	50384427	CHEMBL2031490::US9896452, Example 139	Orexin/Hypocretin receptor type 1	Homo sapiens		 3.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50384427	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50384427&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			70696350	160863510		CHEMBL2031490				ZINC84759402	1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741050	Cc1nc(C(=O)N2CCC[C@H]([C@H]2CNC(=O)c2cccc3occc23)C(F)(F)F)c(s1)-c1ccccc1	InChI=1S/C27H24F3N3O3S/c1-16-32-23(24(37-16)17-7-3-2-4-8-17)26(35)33-13-6-10-20(27(28,29)30)21(33)15-31-25(34)19-9-5-11-22-18(19)12-14-36-22/h2-5,7-9,11-12,14,20-21H,6,10,13,15H2,1H3,(H,31,34)/t20-,21-/m1/s1	LHCWXNBUYBMDHF-NHCUHLMSSA-N	50384427	CHEMBL2031490::US9896452, Example 139	Orexin receptor type 2	Homo sapiens		 17.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50384427	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50384427&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			70696350	160863510		CHEMBL2031490				ZINC84759402	1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741051	O=C(NCC1C2CCC(CC2)N1C(=O)c1ccccc1-c1ccccc1)c1cccc2cccnc12	InChI=1S/C31H29N3O2/c35-30(27-14-6-10-23-11-7-19-32-29(23)27)33-20-28-22-15-17-24(18-16-22)34(28)31(36)26-13-5-4-12-25(26)21-8-2-1-3-9-21/h1-14,19,22,24,28H,15-18,20H2,(H,33,35)	XHWVPYQYSCANOI-UHFFFAOYSA-N	373276	US9896452, Example 140::rac-N-(((1s,4s)-2-([1,1&#8242;-biphenyl]-2-carbonyl)-2-azabicyclo[2.2.2]octan-3-yl)methyl)quinoline-8-carboxamide	Orexin/Hypocretin receptor type 1	Homo sapiens		<100.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373276	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373276&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			71715902	404342378							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741052	Cc1nc(C(=O)N2C3CCC(CC3)C2CNC(=O)c2cccc3cccnc23)c(s1)-c1ccccc1	InChI=1S/C29H28N4O2S/c1-18-32-26(27(36-18)21-7-3-2-4-8-21)29(35)33-22-14-12-19(13-15-22)24(33)17-31-28(34)23-11-5-9-20-10-6-16-30-25(20)23/h2-11,16,19,22,24H,12-15,17H2,1H3,(H,31,34)	KCFDAPJXDCPYPD-UHFFFAOYSA-N	373277	US9896452, Example 141::rac-N-(((1s,4s)-2-(2-methyl-5-phenylthiazole-4-carbonyl)-2-azabicyclo[2.2.2]octan-3-yl)methyl)quinoline-8-carboxamide	Orexin/Hypocretin receptor type 1	Homo sapiens		 2.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373277	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373277&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89748266	404342379							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741053	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1cc(C)ccc1-c1cnn(C)c1	InChI=1S/C25H28F3N5O/c1-16-6-8-20(18-12-31-32(3)15-18)21(11-16)24(34)33-10-4-5-17(2)22(33)14-30-23-9-7-19(13-29-23)25(26,27)28/h6-9,11-13,15,17,22H,4-5,10,14H2,1-3H3,(H,29,30)/t17-,22-/m1/s1	XHXUTIQEYCEZLE-VGOFRKELSA-N	373240	US9896452, Ex. A1::US9896452, Example 103::rac-((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(1-methyl-1H-pyrazol-4-yl)phenyl)methanone	Orexin/Hypocretin receptor type 1	Homo sapiens		 2.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373240	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373240&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89748276	404342342							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741054	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1cc(C)ccc1-c1cnn(C)c1	InChI=1S/C25H28F3N5O/c1-16-6-8-20(18-12-31-32(3)15-18)21(11-16)24(34)33-10-4-5-17(2)22(33)14-30-23-9-7-19(13-29-23)25(26,27)28/h6-9,11-13,15,17,22H,4-5,10,14H2,1-3H3,(H,29,30)/t17-,22-/m1/s1	XHXUTIQEYCEZLE-VGOFRKELSA-N	373240	US9896452, Ex. A1::US9896452, Example 103::rac-((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(1-methyl-1H-pyrazol-4-yl)phenyl)methanone	Orexin receptor type 2	Homo sapiens		 4000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373240	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373240&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			89748276	404342342							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741055	C[C@@H]1CCCN([C@@H]1CNc1nc2ccccc2o1)C(=O)c1cc(C)ccc1-c1cnn(C)c1	InChI=1S/C26H29N5O2/c1-17-10-11-20(19-14-28-30(3)16-19)21(13-17)25(32)31-12-6-7-18(2)23(31)15-27-26-29-22-8-4-5-9-24(22)33-26/h4-5,8-11,13-14,16,18,23H,6-7,12,15H2,1-3H3,(H,27,29)/t18-,23-/m1/s1	VLNTXGZTFHOWLZ-WZONZLPQSA-N	373279	((2S,3R)-2-((Benzo[d]oxazol-2-ylamino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(1-methyl-1H-pyrazol-4-yl)phenyl)methanone::US9896452, Ex. A2	Orexin/Hypocretin receptor type 1	Homo sapiens		 61.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373279	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373279&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728157	404342380							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741056	C[C@@H]1CCCN([C@@H]1CNc1nc2ccccc2o1)C(=O)c1cc(C)ccc1-c1cnn(C)c1	InChI=1S/C26H29N5O2/c1-17-10-11-20(19-14-28-30(3)16-19)21(13-17)25(32)31-12-6-7-18(2)23(31)15-27-26-29-22-8-4-5-9-24(22)33-26/h4-5,8-11,13-14,16,18,23H,6-7,12,15H2,1-3H3,(H,27,29)/t18-,23-/m1/s1	VLNTXGZTFHOWLZ-WZONZLPQSA-N	373279	((2S,3R)-2-((Benzo[d]oxazol-2-ylamino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(1-methyl-1H-pyrazol-4-yl)phenyl)methanone::US9896452, Ex. A2	Orexin receptor type 2	Homo sapiens		>4000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373279	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373279&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117728157	404342380							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741057	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1cc(C)ccc1-c1cn[nH]c1			373280	((2S,3R)-3-Methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(1H-pyrazol-4-yl)phenyl)methanone::US9896452, Ex. A3	Orexin/Hypocretin receptor type 1	Homo sapiens		 6.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373280	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373280&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			145866018	404342381							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741058	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1cc(C)ccc1-c1cn[nH]c1			373280	((2S,3R)-3-Methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(1H-pyrazol-4-yl)phenyl)methanone::US9896452, Ex. A3	Orexin receptor type 2	Homo sapiens		>4000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373280	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373280&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			145866018	404342381							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741059	COc1ncc(cn1)-c1ccc(C)cc1C(=O)N1CCC[C@@H](C)[C@H]1CNc1ccc(cn1)C(F)(F)F	InChI=1S/C26H28F3N5O2/c1-16-6-8-20(18-12-32-25(36-3)33-13-18)21(11-16)24(35)34-10-4-5-17(2)22(34)15-31-23-9-7-19(14-30-23)26(27,28)29/h6-9,11-14,17,22H,4-5,10,15H2,1-3H3,(H,30,31)/t17-,22-/m1/s1	HSBYWIRPTJCKPW-VGOFRKELSA-N	373281	(2-(2-Methoxypyrimidin-5-yl)-5-methylphenyl)((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)methanone::US9896452, Ex. A4	Orexin/Hypocretin receptor type 1	Homo sapiens		 25.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373281	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373281&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727925	404342382							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741060	COc1ncc(cn1)-c1ccc(C)cc1C(=O)N1CCC[C@@H](C)[C@H]1CNc1ccc(cn1)C(F)(F)F	InChI=1S/C26H28F3N5O2/c1-16-6-8-20(18-12-32-25(36-3)33-13-18)21(11-16)24(35)34-10-4-5-17(2)22(34)15-31-23-9-7-19(14-30-23)26(27,28)29/h6-9,11-14,17,22H,4-5,10,15H2,1-3H3,(H,30,31)/t17-,22-/m1/s1	HSBYWIRPTJCKPW-VGOFRKELSA-N	373281	(2-(2-Methoxypyrimidin-5-yl)-5-methylphenyl)((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)methanone::US9896452, Ex. A4	Orexin receptor type 2	Homo sapiens		>4000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373281	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373281&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727925	404342382							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741061	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1cc(C)ccc1-c1cncc(C)c1	InChI=1S/C27H29F3N4O/c1-17-6-8-22(20-11-18(2)13-31-14-20)23(12-17)26(35)34-10-4-5-19(3)24(34)16-33-25-9-7-21(15-32-25)27(28,29)30/h6-9,11-15,19,24H,4-5,10,16H2,1-3H3,(H,32,33)/t19-,24-/m1/s1	WZBOFEVZHIWEBH-NTKDMRAZSA-N	373282	((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(5-methylpyridin-3-yl)phenyl)methanone::US9896452, Ex. A5	Orexin/Hypocretin receptor type 1	Homo sapiens		 6.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373282	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373282&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727967	404342383							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741062	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1cc(C)ccc1-c1cncc(C)c1	InChI=1S/C27H29F3N4O/c1-17-6-8-22(20-11-18(2)13-31-14-20)23(12-17)26(35)34-10-4-5-19(3)24(34)16-33-25-9-7-21(15-32-25)27(28,29)30/h6-9,11-15,19,24H,4-5,10,16H2,1-3H3,(H,32,33)/t19-,24-/m1/s1	WZBOFEVZHIWEBH-NTKDMRAZSA-N	373282	((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(5-methylpyridin-3-yl)phenyl)methanone::US9896452, Ex. A5	Orexin receptor type 2	Homo sapiens		 3500							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373282	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373282&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727967	404342383							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741063	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1cc(C)ccc1-c1ccn(C)c1	InChI=1S/C26H29F3N4O/c1-17-6-8-21(19-10-12-32(3)16-19)22(13-17)25(34)33-11-4-5-18(2)23(33)15-31-24-9-7-20(14-30-24)26(27,28)29/h6-10,12-14,16,18,23H,4-5,11,15H2,1-3H3,(H,30,31)/t18-,23-/m1/s1	SXCLQMIMVGSWJA-WZONZLPQSA-N	373283	((2S,3R)-3-Methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(1-methyl-1H-pyrrol-3-yl)phenyl)methanone::US9896452, Ex. A6	Orexin/Hypocretin receptor type 1	Homo sapiens		 13.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373283	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373283&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727817	404342384							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741064	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1cc(C)ccc1-c1ccn(C)c1	InChI=1S/C26H29F3N4O/c1-17-6-8-21(19-10-12-32(3)16-19)22(13-17)25(34)33-11-4-5-18(2)23(33)15-31-24-9-7-20(14-30-24)26(27,28)29/h6-10,12-14,16,18,23H,4-5,11,15H2,1-3H3,(H,30,31)/t18-,23-/m1/s1	SXCLQMIMVGSWJA-WZONZLPQSA-N	373283	((2S,3R)-3-Methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(1-methyl-1H-pyrrol-3-yl)phenyl)methanone::US9896452, Ex. A6	Orexin receptor type 2	Homo sapiens		>4000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373283	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373283&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727817	404342384							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741065	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1cc(C)ccc1-c1cnccc1C	InChI=1S/C27H29F3N4O/c1-17-6-8-21(23-15-31-11-10-18(23)2)22(13-17)26(35)34-12-4-5-19(3)24(34)16-33-25-9-7-20(14-32-25)27(28,29)30/h6-11,13-15,19,24H,4-5,12,16H2,1-3H3,(H,32,33)/t19-,24-/m1/s1	WZQBTQKBXARIKC-NTKDMRAZSA-N	373284	((2S,3R)-3-Methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(4-methylpyridin-3-yl)phenyl)methanone::US9896452, Ex. A8	Orexin/Hypocretin receptor type 1	Homo sapiens		 58.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373284	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373284&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728307	404342385							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741066	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1cc(C)ccc1-c1cnccc1C	InChI=1S/C27H29F3N4O/c1-17-6-8-21(23-15-31-11-10-18(23)2)22(13-17)26(35)34-12-4-5-19(3)24(34)16-33-25-9-7-20(14-32-25)27(28,29)30/h6-11,13-15,19,24H,4-5,12,16H2,1-3H3,(H,32,33)/t19-,24-/m1/s1	WZQBTQKBXARIKC-NTKDMRAZSA-N	373284	((2S,3R)-3-Methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(4-methylpyridin-3-yl)phenyl)methanone::US9896452, Ex. A8	Orexin receptor type 2	Homo sapiens		>4000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373284	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373284&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117728307	404342385							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741067	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1cc(C)ccc1-c1ccccn1	InChI=1S/C26H27F3N4O/c1-17-8-10-20(22-7-3-4-12-30-22)21(14-17)25(34)33-13-5-6-18(2)23(33)16-32-24-11-9-19(15-31-24)26(27,28)29/h3-4,7-12,14-15,18,23H,5-6,13,16H2,1-2H3,(H,31,32)/t18-,23-/m1/s1	SWYPOYDCCSKIGI-WZONZLPQSA-N	373285	((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(pyridin-2-yl)phenyl)methanone::US9896452, Ex. A9	Orexin/Hypocretin receptor type 1	Homo sapiens		 9.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373285	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373285&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727635	404342386							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741068	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1cc(C)ccc1-c1ccccn1	InChI=1S/C26H27F3N4O/c1-17-8-10-20(22-7-3-4-12-30-22)21(14-17)25(34)33-13-5-6-18(2)23(33)16-32-24-11-9-19(15-31-24)26(27,28)29/h3-4,7-12,14-15,18,23H,5-6,13,16H2,1-2H3,(H,31,32)/t18-,23-/m1/s1	SWYPOYDCCSKIGI-WZONZLPQSA-N	373285	((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(pyridin-2-yl)phenyl)methanone::US9896452, Ex. A9	Orexin receptor type 2	Homo sapiens		 3700							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373285	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373285&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727635	404342386							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741069	C[C@@H]1CCCN([C@@H]1CNc1nc2ccc(Cl)cc2o1)C(=O)c1cc(C)ccc1-c1cnn(C)c1	InChI=1S/C26H28ClN5O2/c1-16-6-8-20(18-13-29-31(3)15-18)21(11-16)25(33)32-10-4-5-17(2)23(32)14-28-26-30-22-9-7-19(27)12-24(22)34-26/h6-9,11-13,15,17,23H,4-5,10,14H2,1-3H3,(H,28,30)/t17-,23-/m1/s1	IBZFIVQQDNDPRN-UZUQRXQVSA-N	373286	((2S,3R)-2-(((6-Chlorobenzo[d]oxazol-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(1-methyl-1H-pyrazol-4-yl)phenyl)methanone::US9896452, Ex. A10	Orexin/Hypocretin receptor type 1	Homo sapiens		 81.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373286	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373286&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728062	404342387							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741070	C[C@@H]1CCCN([C@@H]1CNc1nc2ccc(Cl)cc2o1)C(=O)c1cc(C)ccc1-c1cnn(C)c1	InChI=1S/C26H28ClN5O2/c1-16-6-8-20(18-13-29-31(3)15-18)21(11-16)25(33)32-10-4-5-17(2)23(32)14-28-26-30-22-9-7-19(27)12-24(22)34-26/h6-9,11-13,15,17,23H,4-5,10,14H2,1-3H3,(H,28,30)/t17-,23-/m1/s1	IBZFIVQQDNDPRN-UZUQRXQVSA-N	373286	((2S,3R)-2-(((6-Chlorobenzo[d]oxazol-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(1-methyl-1H-pyrazol-4-yl)phenyl)methanone::US9896452, Ex. A10	Orexin receptor type 2	Homo sapiens		>4000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373286	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373286&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117728062	404342387							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741071	C[C@@H]1CCCN([C@@H]1CNc1nc2cc(Cl)ccc2o1)C(=O)c1cc(C)ccc1-n1nccn1	InChI=1S/C24H25ClN6O2/c1-15-5-7-20(31-27-9-10-28-31)18(12-15)23(32)30-11-3-4-16(2)21(30)14-26-24-29-19-13-17(25)6-8-22(19)33-24/h5-10,12-13,16,21H,3-4,11,14H2,1-2H3,(H,26,29)/t16-,21-/m1/s1	NZVFTQSJWLBCIO-IIBYNOLFSA-N	373287	((2S,3R)-2-(((5-Chlorobenzo[d]oxazol-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A11	Orexin/Hypocretin receptor type 1	Homo sapiens		 3.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373287	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373287&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89748195	404342388							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741072	C[C@@H]1CCCN([C@@H]1CNc1nc2cc(Cl)ccc2o1)C(=O)c1cc(C)ccc1-n1nccn1	InChI=1S/C24H25ClN6O2/c1-15-5-7-20(31-27-9-10-28-31)18(12-15)23(32)30-11-3-4-16(2)21(30)14-26-24-29-19-13-17(25)6-8-22(19)33-24/h5-10,12-13,16,21H,3-4,11,14H2,1-2H3,(H,26,29)/t16-,21-/m1/s1	NZVFTQSJWLBCIO-IIBYNOLFSA-N	373287	((2S,3R)-2-(((5-Chlorobenzo[d]oxazol-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A11	Orexin receptor type 2	Homo sapiens		 45.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373287	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373287&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			89748195	404342388							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741073	C[C@@H]1CCCN([C@@H]1CNc1nc2cc(Cl)ccc2o1)C(=O)c1cc(C)ccc1-c1cnn(C)c1	InChI=1S/C26H28ClN5O2/c1-16-6-8-20(18-13-29-31(3)15-18)21(11-16)25(33)32-10-4-5-17(2)23(32)14-28-26-30-22-12-19(27)7-9-24(22)34-26/h6-9,11-13,15,17,23H,4-5,10,14H2,1-3H3,(H,28,30)/t17-,23-/m1/s1	XCCLELVOLKRXME-UZUQRXQVSA-N	373288	((2S,3R)-2-(((5-chlorobenzo[d]oxazol-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(1-methyl-1H-pyrazol-4-yl)phenyl)methanone::US9896452, Ex. A12	Orexin/Hypocretin receptor type 1	Homo sapiens		 20.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373288	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373288&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89748189	404342389							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741074	C[C@@H]1CCCN([C@@H]1CNc1nc2cc(Cl)ccc2o1)C(=O)c1cc(C)ccc1-c1cnn(C)c1	InChI=1S/C26H28ClN5O2/c1-16-6-8-20(18-13-29-31(3)15-18)21(11-16)25(33)32-10-4-5-17(2)23(32)14-28-26-30-22-12-19(27)7-9-24(22)34-26/h6-9,11-13,15,17,23H,4-5,10,14H2,1-3H3,(H,28,30)/t17-,23-/m1/s1	XCCLELVOLKRXME-UZUQRXQVSA-N	373288	((2S,3R)-2-(((5-chlorobenzo[d]oxazol-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(1-methyl-1H-pyrazol-4-yl)phenyl)methanone::US9896452, Ex. A12	Orexin receptor type 2	Homo sapiens		 800							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373288	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373288&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			89748189	404342389							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741075	C[C@@H]1CCCN([C@@H]1CNc1nc2cc(Cl)ccc2o1)C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C25H24ClFN4O2S/c1-14-4-3-11-31(20(14)13-28-25-30-19-12-17(26)7-10-21(19)33-25)24(32)22-23(34-15(2)29-22)16-5-8-18(27)9-6-16/h5-10,12,14,20H,3-4,11,13H2,1-2H3,(H,28,30)/t14-,20-/m1/s1	CDQLBCDCGGHTKS-JLTOFOAXSA-N	373289	((2S,3R)-2-(((5-Chlorobenzo[d]oxazol-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone::US9896452, Ex. A13::US9896452, Ex. A84	Orexin/Hypocretin receptor type 1	Homo sapiens		 3.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373289	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373289&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727881	404342390							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741076	C[C@@H]1CCCN([C@@H]1CNc1nc2cc(Cl)ccc2o1)C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C25H24ClFN4O2S/c1-14-4-3-11-31(20(14)13-28-25-30-19-12-17(26)7-10-21(19)33-25)24(32)22-23(34-15(2)29-22)16-5-8-18(27)9-6-16/h5-10,12,14,20H,3-4,11,13H2,1-2H3,(H,28,30)/t14-,20-/m1/s1	CDQLBCDCGGHTKS-JLTOFOAXSA-N	373289	((2S,3R)-2-(((5-Chlorobenzo[d]oxazol-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone::US9896452, Ex. A13::US9896452, Ex. A84	Orexin receptor type 2	Homo sapiens		>4000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373289	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373289&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727881	404342390							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741077	C[C@@H]1CCCN([C@@H]1CNc1nc2ccc(Cl)cc2o1)C(=O)c1cc(C)ccc1-n1nccn1	InChI=1S/C24H25ClN6O2/c1-15-5-8-20(31-27-9-10-28-31)18(12-15)23(32)30-11-3-4-16(2)21(30)14-26-24-29-19-7-6-17(25)13-22(19)33-24/h5-10,12-13,16,21H,3-4,11,14H2,1-2H3,(H,26,29)/t16-,21-/m1/s1	FZCMCYCGHOTQKS-IIBYNOLFSA-N	373290	((2S,3R)-2-(((6-Chlorobenzo[d]oxazol-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A14	Orexin/Hypocretin receptor type 1	Homo sapiens		 10.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373290	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373290&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89748191	404342391							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741078	C[C@@H]1CCCN([C@@H]1CNc1nc2ccc(Cl)cc2o1)C(=O)c1cc(C)ccc1-n1nccn1	InChI=1S/C24H25ClN6O2/c1-15-5-8-20(31-27-9-10-28-31)18(12-15)23(32)30-11-3-4-16(2)21(30)14-26-24-29-19-7-6-17(25)13-22(19)33-24/h5-10,12-13,16,21H,3-4,11,14H2,1-2H3,(H,26,29)/t16-,21-/m1/s1	FZCMCYCGHOTQKS-IIBYNOLFSA-N	373290	((2S,3R)-2-(((6-Chlorobenzo[d]oxazol-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A14	Orexin receptor type 2	Homo sapiens		 620							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373290	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373290&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			89748191	404342391							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741079	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1cc(C)ccc1-n1ncnc1C	InChI=1S/C24H27F3N6O/c1-15-6-8-20(33-17(3)30-14-31-33)19(11-15)23(34)32-10-4-5-16(2)21(32)13-29-22-9-7-18(12-28-22)24(25,26)27/h6-9,11-12,14,16,21H,4-5,10,13H2,1-3H3,(H,28,29)/t16-,21-/m1/s1	WBDFFUDCLSSREL-IIBYNOLFSA-N	373291	((2S,3R)-3-Methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(5-methyl-1H-1,2,4-triazol-1-yl)phenyl)methanone::US9896452, Ex. A16	Orexin/Hypocretin receptor type 1	Homo sapiens		 260							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373291	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373291&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727728	404342392							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741080	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1cc(C)ccc1-n1ncnc1C	InChI=1S/C24H27F3N6O/c1-15-6-8-20(33-17(3)30-14-31-33)19(11-15)23(34)32-10-4-5-16(2)21(32)13-29-22-9-7-18(12-28-22)24(25,26)27/h6-9,11-12,14,16,21H,4-5,10,13H2,1-3H3,(H,28,29)/t16-,21-/m1/s1	WBDFFUDCLSSREL-IIBYNOLFSA-N	373291	((2S,3R)-3-Methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(5-methyl-1H-1,2,4-triazol-1-yl)phenyl)methanone::US9896452, Ex. A16	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373291	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373291&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727728	404342392							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741081	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1cc(C)ccc1-n1cnc(C)n1	InChI=1S/C24H27F3N6O/c1-15-6-8-20(33-14-30-17(3)31-33)19(11-15)23(34)32-10-4-5-16(2)21(32)13-29-22-9-7-18(12-28-22)24(25,26)27/h6-9,11-12,14,16,21H,4-5,10,13H2,1-3H3,(H,28,29)/t16-,21-/m1/s1	QGIJVZQSMSANOU-IIBYNOLFSA-N	373292	((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl)methanone::US9896452, Ex. A17	Orexin/Hypocretin receptor type 1	Homo sapiens		 20.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373292	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373292&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728043	404342393							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741082	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1cc(C)ccc1-n1cnc(C)n1	InChI=1S/C24H27F3N6O/c1-15-6-8-20(33-14-30-17(3)31-33)19(11-15)23(34)32-10-4-5-16(2)21(32)13-29-22-9-7-18(12-28-22)24(25,26)27/h6-9,11-12,14,16,21H,4-5,10,13H2,1-3H3,(H,28,29)/t16-,21-/m1/s1	QGIJVZQSMSANOU-IIBYNOLFSA-N	373292	((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl)methanone::US9896452, Ex. A17	Orexin receptor type 2	Homo sapiens		>4000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373292	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373292&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117728043	404342393							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741083	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1cc(C)ccc1-c1ccn(C)n1	InChI=1S/C25H28F3N5O/c1-16-6-8-19(21-10-12-32(3)31-21)20(13-16)24(34)33-11-4-5-17(2)22(33)15-30-23-9-7-18(14-29-23)25(26,27)28/h6-10,12-14,17,22H,4-5,11,15H2,1-3H3,(H,29,30)/t17-,22-/m1/s1	LPTVVOAHTAJOKU-VGOFRKELSA-N	373293	((2S,3R)-3-Methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(1-methyl-1H-pyrazol-3-yl)phenyl)methanone::US9896452, Ex. A18	Orexin/Hypocretin receptor type 1	Homo sapiens		 7.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373293	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373293&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728078	404342394							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741084	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1cc(C)ccc1-c1ccn(C)n1	InChI=1S/C25H28F3N5O/c1-16-6-8-19(21-10-12-32(3)31-21)20(13-16)24(34)33-11-4-5-17(2)22(33)15-30-23-9-7-18(14-29-23)25(26,27)28/h6-10,12-14,17,22H,4-5,11,15H2,1-3H3,(H,29,30)/t17-,22-/m1/s1	LPTVVOAHTAJOKU-VGOFRKELSA-N	373293	((2S,3R)-3-Methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(1-methyl-1H-pyrazol-3-yl)phenyl)methanone::US9896452, Ex. A18	Orexin receptor type 2	Homo sapiens		>4000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373293	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373293&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117728078	404342394							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741085	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1cc(C)ccc1-c1cnccn1	InChI=1S/C25H26F3N5O/c1-16-5-7-19(21-14-29-9-10-30-21)20(12-16)24(34)33-11-3-4-17(2)22(33)15-32-23-8-6-18(13-31-23)25(26,27)28/h5-10,12-14,17,22H,3-4,11,15H2,1-2H3,(H,31,32)/t17-,22-/m1/s1	FXEJYJOLEHLEJH-VGOFRKELSA-N	373294	((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(pyrazin-2-yl)phenyl)methanone::US9896452, Ex. A19	Orexin/Hypocretin receptor type 1	Homo sapiens		 4.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373294	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373294&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727645	404342395							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741086	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1cc(C)ccc1-c1cnccn1	InChI=1S/C25H26F3N5O/c1-16-5-7-19(21-14-29-9-10-30-21)20(12-16)24(34)33-11-3-4-17(2)22(33)15-32-23-8-6-18(13-31-23)25(26,27)28/h5-10,12-14,17,22H,3-4,11,15H2,1-2H3,(H,31,32)/t17-,22-/m1/s1	FXEJYJOLEHLEJH-VGOFRKELSA-N	373294	((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(pyrazin-2-yl)phenyl)methanone::US9896452, Ex. A19	Orexin receptor type 2	Homo sapiens		 230							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373294	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373294&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727645	404342395							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741087	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1cc(C)ccc1-c1nccn1C	InChI=1S/C25H28F3N5O/c1-16-6-8-19(23-29-10-12-32(23)3)20(13-16)24(34)33-11-4-5-17(2)21(33)15-31-22-9-7-18(14-30-22)25(26,27)28/h6-10,12-14,17,21H,4-5,11,15H2,1-3H3,(H,30,31)/t17-,21-/m1/s1	RXNRYFCAEZNLBC-DYESRHJHSA-N	373295	((2S,3R)-3-Methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(1-methyl-1H-imidazol-2-yl)phenyl)methanone::US9896452, Ex. A20	Orexin/Hypocretin receptor type 1	Homo sapiens		 37.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373295	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373295&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727913	404342396							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741088	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1cc(C)ccc1-c1nccn1C	InChI=1S/C25H28F3N5O/c1-16-6-8-19(23-29-10-12-32(23)3)20(13-16)24(34)33-11-4-5-17(2)21(33)15-31-22-9-7-18(14-30-22)25(26,27)28/h6-10,12-14,17,21H,4-5,11,15H2,1-3H3,(H,30,31)/t17-,21-/m1/s1	RXNRYFCAEZNLBC-DYESRHJHSA-N	373295	((2S,3R)-3-Methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(1-methyl-1H-imidazol-2-yl)phenyl)methanone::US9896452, Ex. A20	Orexin receptor type 2	Homo sapiens		>4000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373295	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373295&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727913	404342396							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741089	COc1ccnc(n1)-c1ccc(C)cc1C(=O)N1CCC[C@@H](C)[C@H]1CNc1ccc(cn1)C(F)(F)F	InChI=1S/C26H28F3N5O2/c1-16-6-8-19(24-30-11-10-23(33-24)36-3)20(13-16)25(35)34-12-4-5-17(2)21(34)15-32-22-9-7-18(14-31-22)26(27,28)29/h6-11,13-14,17,21H,4-5,12,15H2,1-3H3,(H,31,32)/t17-,21-/m1/s1	HKCVHCDKDFQEJF-DYESRHJHSA-N	373296	(2-(4-Methoxypyrimidin-2-yl)-5-methylphenyl)((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)methanone::US9896452, Ex. A21	Orexin/Hypocretin receptor type 1	Homo sapiens		 13.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373296	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373296&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728179	404342397							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741090	COc1ccnc(n1)-c1ccc(C)cc1C(=O)N1CCC[C@@H](C)[C@H]1CNc1ccc(cn1)C(F)(F)F	InChI=1S/C26H28F3N5O2/c1-16-6-8-19(24-30-11-10-23(33-24)36-3)20(13-16)25(35)34-12-4-5-17(2)21(34)15-32-22-9-7-18(14-31-22)26(27,28)29/h6-11,13-14,17,21H,4-5,12,15H2,1-3H3,(H,31,32)/t17-,21-/m1/s1	HKCVHCDKDFQEJF-DYESRHJHSA-N	373296	(2-(4-Methoxypyrimidin-2-yl)-5-methylphenyl)((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)methanone::US9896452, Ex. A21	Orexin receptor type 2	Homo sapiens		>4000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373296	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373296&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117728179	404342397							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741091	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1cc(C)ccc1-c1nn[nH]n1			373297	((2S,3R)-3-Methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(2H-tetrazol-5-yl)phenyl)methanone::US9896452, Ex. A23	Orexin/Hypocretin receptor type 1	Homo sapiens		>1000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373297	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373297&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727769	404342398							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741092	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1cc(C)ccc1-c1nccs1	InChI=1S/C24H25F3N4OS/c1-15-5-7-18(22-28-9-11-33-22)19(12-15)23(32)31-10-3-4-16(2)20(31)14-30-21-8-6-17(13-29-21)24(25,26)27/h5-9,11-13,16,20H,3-4,10,14H2,1-2H3,(H,29,30)/t16-,20-/m1/s1	LWRSQRDSWOOLGR-OXQOHEQNSA-N	373298	((2S,3R)-3-Methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(thiazol-2-yl)phenyl)methanone::US9896452, Ex. A24	Orexin/Hypocretin receptor type 1	Homo sapiens		 11.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373298	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373298&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727916	404342399							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741093	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1cc(C)ccc1-c1nccs1	InChI=1S/C24H25F3N4OS/c1-15-5-7-18(22-28-9-11-33-22)19(12-15)23(32)31-10-3-4-16(2)20(31)14-30-21-8-6-17(13-29-21)24(25,26)27/h5-9,11-13,16,20H,3-4,10,14H2,1-2H3,(H,29,30)/t16-,20-/m1/s1	LWRSQRDSWOOLGR-OXQOHEQNSA-N	373298	((2S,3R)-3-Methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(thiazol-2-yl)phenyl)methanone::US9896452, Ex. A24	Orexin receptor type 2	Homo sapiens		 410							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373298	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373298&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727916	404342399							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741094	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1cc(C)ccc1-c1cncs1	InChI=1S/C24H25F3N4OS/c1-15-5-7-18(21-13-28-14-33-21)19(10-15)23(32)31-9-3-4-16(2)20(31)12-30-22-8-6-17(11-29-22)24(25,26)27/h5-8,10-11,13-14,16,20H,3-4,9,12H2,1-2H3,(H,29,30)/t16-,20-/m1/s1	GZVCTONBAFBSPO-OXQOHEQNSA-N	373299	((2S,3R)-3-Methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(thiazol-5-yl)phenyl)methanone::US9896452, Ex. A25	Orexin/Hypocretin receptor type 1	Homo sapiens		 5.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373299	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373299&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728514	404342400							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741095	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1cc(C)ccc1-c1cncs1	InChI=1S/C24H25F3N4OS/c1-15-5-7-18(21-13-28-14-33-21)19(10-15)23(32)31-9-3-4-16(2)20(31)12-30-22-8-6-17(11-29-22)24(25,26)27/h5-8,10-11,13-14,16,20H,3-4,9,12H2,1-2H3,(H,29,30)/t16-,20-/m1/s1	GZVCTONBAFBSPO-OXQOHEQNSA-N	373299	((2S,3R)-3-Methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(thiazol-5-yl)phenyl)methanone::US9896452, Ex. A25	Orexin receptor type 2	Homo sapiens		>4000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373299	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373299&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117728514	404342400							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741096	C[C@@H]1CCCN([C@@H]1CNc1nc2cc(Cl)ccc2o1)C(=O)c1cc(C)ccc1-n1cnc(C)n1	InChI=1S/C25H27ClN6O2/c1-15-6-8-21(32-14-28-17(3)30-32)19(11-15)24(33)31-10-4-5-16(2)22(31)13-27-25-29-20-12-18(26)7-9-23(20)34-25/h6-9,11-12,14,16,22H,4-5,10,13H2,1-3H3,(H,27,29)/t16-,22-/m1/s1	REPWWTRXQVIIOM-OPAMFIHVSA-N	373300	((2S,3R)-2-(((5-Chlorobenzo[d]oxazol-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl)methanone::US9896452, Ex. A29	Orexin/Hypocretin receptor type 1	Homo sapiens		 87.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373300	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373300&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89748175	404342401							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741097	C[C@@H]1CCCN([C@@H]1CNc1nc2cc(Cl)ccc2o1)C(=O)c1cc(C)ccc1-n1cnc(C)n1	InChI=1S/C25H27ClN6O2/c1-15-6-8-21(32-14-28-17(3)30-32)19(11-15)24(33)31-10-4-5-16(2)22(31)13-27-25-29-20-12-18(26)7-9-23(20)34-25/h6-9,11-12,14,16,22H,4-5,10,13H2,1-3H3,(H,27,29)/t16-,22-/m1/s1	REPWWTRXQVIIOM-OPAMFIHVSA-N	373300	((2S,3R)-2-(((5-Chlorobenzo[d]oxazol-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl)methanone::US9896452, Ex. A29	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373300	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373300&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			89748175	404342401							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741098	C[C@@H]1CCCN([C@@H]1CNc1nc2cc(Cl)ccc2o1)C(=O)c1cc(C)ccc1-c1ccccn1	InChI=1S/C27H27ClN4O2/c1-17-8-10-20(22-7-3-4-12-29-22)21(14-17)26(33)32-13-5-6-18(2)24(32)16-30-27-31-23-15-19(28)9-11-25(23)34-27/h3-4,7-12,14-15,18,24H,5-6,13,16H2,1-2H3,(H,30,31)/t18-,24-/m1/s1	JVJPBEPAVWKUIU-HOYKHHGWSA-N	373301	((2S,3R)-2-(((5-Chlorobenzo[d]oxazol-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(pyridin-2-yl)phenyl)methanone::US9896452, Ex. A32	Orexin/Hypocretin receptor type 1	Homo sapiens		 9.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373301	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373301&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728094	404342402							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741099	C[C@@H]1CCCN([C@@H]1CNc1nc2cc(Cl)ccc2o1)C(=O)c1cc(C)ccc1-c1ccccn1	InChI=1S/C27H27ClN4O2/c1-17-8-10-20(22-7-3-4-12-29-22)21(14-17)26(33)32-13-5-6-18(2)24(32)16-30-27-31-23-15-19(28)9-11-25(23)34-27/h3-4,7-12,14-15,18,24H,5-6,13,16H2,1-2H3,(H,30,31)/t18-,24-/m1/s1	JVJPBEPAVWKUIU-HOYKHHGWSA-N	373301	((2S,3R)-2-(((5-Chlorobenzo[d]oxazol-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(pyridin-2-yl)phenyl)methanone::US9896452, Ex. A32	Orexin receptor type 2	Homo sapiens		 420							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373301	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373301&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117728094	404342402							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741100	C[C@@H]1CCCN([C@@H]1CNc1nc2cc(Cl)ccc2o1)C(=O)c1cc(C)ccc1-c1ccnc(C)c1	InChI=1S/C28H29ClN4O2/c1-17-6-8-22(20-10-11-30-19(3)14-20)23(13-17)27(34)33-12-4-5-18(2)25(33)16-31-28-32-24-15-21(29)7-9-26(24)35-28/h6-11,13-15,18,25H,4-5,12,16H2,1-3H3,(H,31,32)/t18-,25-/m1/s1	DGFIWWHUESCGRO-IQGLISFBSA-N	373302	((2S,3R)-2-(((5-Chlorobenzo[d]oxazol-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(2-methylpyridin-4-yl)phenyl)methanone::US9896452, Ex. A37	Orexin/Hypocretin receptor type 1	Homo sapiens		 4.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373302	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373302&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728047	404342403							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741101	C[C@@H]1CCCN([C@@H]1CNc1nc2cc(Cl)ccc2o1)C(=O)c1cc(C)ccc1-c1ccc(C)nc1	InChI=1S/C28H29ClN4O2/c1-17-6-10-22(20-8-7-19(3)30-15-20)23(13-17)27(34)33-12-4-5-18(2)25(33)16-31-28-32-24-14-21(29)9-11-26(24)35-28/h6-11,13-15,18,25H,4-5,12,16H2,1-3H3,(H,31,32)/t18-,25-/m1/s1	SZZAIOXALICHOP-IQGLISFBSA-N	373303	((2S,3R)-2-(((5-Chlorobenzo[d]oxazol-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(6-methylpyridin-3-yl)phenyl)methanone::US9896452, Ex. A38	Orexin/Hypocretin receptor type 1	Homo sapiens		 100.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373303	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373303&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727819	404342404							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741102	C[C@@H]1CCCN([C@@H]1CNc1nc2cc(Cl)ccc2o1)C(=O)c1cc(C)ccc1-c1ccc(C)nc1	InChI=1S/C28H29ClN4O2/c1-17-6-10-22(20-8-7-19(3)30-15-20)23(13-17)27(34)33-12-4-5-18(2)25(33)16-31-28-32-24-14-21(29)9-11-26(24)35-28/h6-11,13-15,18,25H,4-5,12,16H2,1-3H3,(H,31,32)/t18-,25-/m1/s1	SZZAIOXALICHOP-IQGLISFBSA-N	373303	((2S,3R)-2-(((5-Chlorobenzo[d]oxazol-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(6-methylpyridin-3-yl)phenyl)methanone::US9896452, Ex. A38	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373303	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373303&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727819	404342404							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741103	C[C@@H]1CCCN([C@@H]1CNc1ncc(Cl)cn1)C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C22H23ClFN5OS/c1-13-4-3-9-29(18(13)12-27-22-25-10-16(23)11-26-22)21(30)19-20(31-14(2)28-19)15-5-7-17(24)8-6-15/h5-8,10-11,13,18H,3-4,9,12H2,1-2H3,(H,25,26,27)/t13-,18-/m1/s1	HOYRKLOSSPBUHN-FZKQIMNGSA-N	373221	US9896452, Ex. A41::US9896452, Example 82::rac-((2S,3R)-2-(((5-chloropyrimidin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone	Orexin/Hypocretin receptor type 1	Homo sapiens		 4.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373221	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373221&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89739388	404342323							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741104	C[C@@H]1CCCN([C@@H]1CNc1ncc(Cl)cn1)C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C22H23ClFN5OS/c1-13-4-3-9-29(18(13)12-27-22-25-10-16(23)11-26-22)21(30)19-20(31-14(2)28-19)15-5-7-17(24)8-6-15/h5-8,10-11,13,18H,3-4,9,12H2,1-2H3,(H,25,26,27)/t13-,18-/m1/s1	HOYRKLOSSPBUHN-FZKQIMNGSA-N	373221	US9896452, Ex. A41::US9896452, Example 82::rac-((2S,3R)-2-(((5-chloropyrimidin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone	Orexin receptor type 2	Homo sapiens		>4000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373221	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373221&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			89739388	404342323							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741105	C[C@H]1CCCN([C@H]1CNc1nc2ccccc2o1)C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C25H25FN4O2S/c1-15-6-5-13-30(20(15)14-27-25-29-19-7-3-4-8-21(19)32-25)24(31)22-23(33-16(2)28-22)17-9-11-18(26)12-10-17/h3-4,7-12,15,20H,5-6,13-14H2,1-2H3,(H,27,29)/t15-,20-/m0/s1	RSCBRJAESFFMDG-YWZLYKJASA-N	373305	((2R,3S)-2-((Benzo[d]oxazol-2-ylamino)methyl)-3-methylpiperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone::US9896452, Ex. A42	Orexin/Hypocretin receptor type 1	Homo sapiens		>1000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373305	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373305&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728051	404342405							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741106	C[C@H]1CCCN([C@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C24H24F4N4OS/c1-14-4-3-11-32(19(14)13-30-20-10-7-17(12-29-20)24(26,27)28)23(33)21-22(34-15(2)31-21)16-5-8-18(25)9-6-16/h5-10,12,14,19H,3-4,11,13H2,1-2H3,(H,29,30)/t14-,19-/m0/s1	SVCKMOGUOXOQCC-LIRRHRJNSA-N	373306	(5-(4-Fluorophenyl)-2-methylthiazol-4-yl)((2R,3S)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)methanone::US9896452, Ex. A43	Orexin/Hypocretin receptor type 1	Homo sapiens		 670							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373306	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373306&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727822	404342406							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741107	C[C@H]1CCCN([C@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C24H24F4N4OS/c1-14-4-3-11-32(19(14)13-30-20-10-7-17(12-29-20)24(26,27)28)23(33)21-22(34-15(2)31-21)16-5-8-18(25)9-6-16/h5-10,12,14,19H,3-4,11,13H2,1-2H3,(H,29,30)/t14-,19-/m0/s1	SVCKMOGUOXOQCC-LIRRHRJNSA-N	373306	(5-(4-Fluorophenyl)-2-methylthiazol-4-yl)((2R,3S)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)methanone::US9896452, Ex. A43	Orexin receptor type 2	Homo sapiens		>4000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373306	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373306&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727822	404342406							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741108	C[C@@H]1CCCN([C@@H]1CNc1ccc(F)cn1)C(=O)c1cc(C)ccc1-c1cnn(C)c1	InChI=1S/C24H28FN5O/c1-16-6-8-20(18-12-28-29(3)15-18)21(11-16)24(31)30-10-4-5-17(2)22(30)14-27-23-9-7-19(25)13-26-23/h6-9,11-13,15,17,22H,4-5,10,14H2,1-3H3,(H,26,27)/t17-,22-/m1/s1	TZEVSDDQMYMRFX-VGOFRKELSA-N	373307	((2S,3R)-2-(((5-Fluoropyridin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(1-methyl-1H-pyrazol-4-yl)phenyl)methanone::US9896452, Ex. A44	Orexin/Hypocretin receptor type 1	Homo sapiens		 11.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373307	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373307&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728039	404342407							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741109	C[C@@H]1CCCN([C@@H]1CNc1ccc(F)cn1)C(=O)c1cc(C)ccc1-c1cnn(C)c1	InChI=1S/C24H28FN5O/c1-16-6-8-20(18-12-28-29(3)15-18)21(11-16)24(31)30-10-4-5-17(2)22(30)14-27-23-9-7-19(25)13-26-23/h6-9,11-13,15,17,22H,4-5,10,14H2,1-3H3,(H,26,27)/t17-,22-/m1/s1	TZEVSDDQMYMRFX-VGOFRKELSA-N	373307	((2S,3R)-2-(((5-Fluoropyridin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(1-methyl-1H-pyrazol-4-yl)phenyl)methanone::US9896452, Ex. A44	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373307	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373307&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117728039	404342407							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741110	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C#N)C(=O)c1cc(C)ccc1-c1cnn(C)c1	InChI=1S/C25H28N6O/c1-17-6-8-21(20-14-29-30(3)16-20)22(11-17)25(32)31-10-4-5-18(2)23(31)15-28-24-9-7-19(12-26)13-27-24/h6-9,11,13-14,16,18,23H,4-5,10,15H2,1-3H3,(H,27,28)/t18-,23-/m1/s1	DZCPKVJWHPFIKG-WZONZLPQSA-N	373308	6-((((2S,3R)-3-Methyl-1-(5-methyl-2-(1-methyl-1H-pyrazol-4-yl)benzoyl)piperidin-2-yl)methyl)amino)nicotinonitrile::US9896452, Ex. A45	Orexin/Hypocretin receptor type 1	Homo sapiens		>1000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373308	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373308&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728093	404342408							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741111	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C#N)C(=O)c1cc(C)ccc1-n1nccn1	InChI=1S/C23H25N7O/c1-16-5-7-20(30-27-9-10-28-30)19(12-16)23(31)29-11-3-4-17(2)21(29)15-26-22-8-6-18(13-24)14-25-22/h5-10,12,14,17,21H,3-4,11,15H2,1-2H3,(H,25,26)/t17-,21-/m1/s1	MGSGNMUJJXUGRQ-DYESRHJHSA-N	373309	6-((((2S,3R)-3-Methyl-1-(5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl)piperidin-2-yl)methyl)amino)nicotinonitrile::US9896452, Ex. A127::US9896452, Ex. A46	Orexin/Hypocretin receptor type 1	Homo sapiens		 5.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373309	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373309&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727834	404342409							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741112	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C#N)C(=O)c1cc(C)ccc1-n1nccn1	InChI=1S/C23H25N7O/c1-16-5-7-20(30-27-9-10-28-30)19(12-16)23(31)29-11-3-4-17(2)21(29)15-26-22-8-6-18(13-24)14-25-22/h5-10,12,14,17,21H,3-4,11,15H2,1-2H3,(H,25,26)/t17-,21-/m1/s1	MGSGNMUJJXUGRQ-DYESRHJHSA-N	373309	6-((((2S,3R)-3-Methyl-1-(5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl)piperidin-2-yl)methyl)amino)nicotinonitrile::US9896452, Ex. A127::US9896452, Ex. A46	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373309	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373309&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727834	404342409							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741113	C[C@@H]1CCCN([C@@H]1CNc1ccc(F)cn1)C(=O)c1cc(C)ccc1-n1nccn1	InChI=1S/C22H25FN6O/c1-15-5-7-19(29-26-9-10-27-29)18(12-15)22(30)28-11-3-4-16(2)20(28)14-25-21-8-6-17(23)13-24-21/h5-10,12-13,16,20H,3-4,11,14H2,1-2H3,(H,24,25)/t16-,20-/m1/s1	XUINUSYAEFGXPE-OXQOHEQNSA-N	373310	((2S,3R)-2-(((5-Fluoropyridin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A47	Orexin/Hypocretin receptor type 1	Homo sapiens		 150							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373310	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373310&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728203	404342410							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741114	C[C@@H]1CCCN([C@@H]1CNc1ccc(F)cn1)C(=O)c1cc(C)ccc1-n1nccn1	InChI=1S/C22H25FN6O/c1-15-5-7-19(29-26-9-10-27-29)18(12-15)22(30)28-11-3-4-16(2)20(28)14-25-21-8-6-17(23)13-24-21/h5-10,12-13,16,20H,3-4,11,14H2,1-2H3,(H,24,25)/t16-,20-/m1/s1	XUINUSYAEFGXPE-OXQOHEQNSA-N	373310	((2S,3R)-2-(((5-Fluoropyridin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A47	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373310	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373310&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117728203	404342410							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741115	C[C@@H]1CCCN([C@@H]1CNc1ccc(C)cn1)C(=O)c1cc(C)ccc1-n1nccn1	InChI=1S/C23H28N6O/c1-16-6-8-20(29-26-10-11-27-29)19(13-16)23(30)28-12-4-5-18(3)21(28)15-25-22-9-7-17(2)14-24-22/h6-11,13-14,18,21H,4-5,12,15H2,1-3H3,(H,24,25)/t18-,21-/m1/s1	WBTXYPRRDPEDHA-WIYYLYMNSA-N	373312	((2S,3R)-3-Methyl-2-(((5-methylpyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A48	Orexin/Hypocretin receptor type 1	Homo sapiens		 25.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373312	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373312&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727745	404342411							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741116	C[C@@H]1CCCN([C@@H]1CNc1ccc(C)cn1)C(=O)c1cc(C)ccc1-n1nccn1	InChI=1S/C23H28N6O/c1-16-6-8-20(29-26-10-11-27-29)19(13-16)23(30)28-12-4-5-18(3)21(28)15-25-22-9-7-17(2)14-24-22/h6-11,13-14,18,21H,4-5,12,15H2,1-3H3,(H,24,25)/t18-,21-/m1/s1	WBTXYPRRDPEDHA-WIYYLYMNSA-N	373312	((2S,3R)-3-Methyl-2-(((5-methylpyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A48	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373312	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373312&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727745	404342411							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741117	C[C@@H]1CCCN([C@@H]1CNc1ccc(C)cn1)C(=O)c1cc(C)ccc1-c1cnn(C)c1	InChI=1S/C25H31N5O/c1-17-7-9-21(20-14-28-29(4)16-20)22(12-17)25(31)30-11-5-6-19(3)23(30)15-27-24-10-8-18(2)13-26-24/h7-10,12-14,16,19,23H,5-6,11,15H2,1-4H3,(H,26,27)/t19-,23-/m1/s1	CHIULFAHBAWYRK-AUSIDOKSSA-N	373313	((2S,3R)-3-Methyl-2-(((5-methylpyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(1-methyl-1H-pyrazol-4-yl)phenyl)methanone::US9896452, Ex. A49	Orexin/Hypocretin receptor type 1	Homo sapiens		 500							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373313	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373313&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728261	404342412							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741118	C[C@@H]1CCCN([C@@H]1CNc1ccc(C)cn1)C(=O)c1cc(C)ccc1-c1cnn(C)c1	InChI=1S/C25H31N5O/c1-17-7-9-21(20-14-28-29(4)16-20)22(12-17)25(31)30-11-5-6-19(3)23(30)15-27-24-10-8-18(2)13-26-24/h7-10,12-14,16,19,23H,5-6,11,15H2,1-4H3,(H,26,27)/t19-,23-/m1/s1	CHIULFAHBAWYRK-AUSIDOKSSA-N	373313	((2S,3R)-3-Methyl-2-(((5-methylpyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(1-methyl-1H-pyrazol-4-yl)phenyl)methanone::US9896452, Ex. A49	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373313	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373313&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117728261	404342412							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741119	C[C@@H]1CCCN([C@@H]1CNc1nc2cc(Cl)ccc2o1)C(=O)c1cc(C)ccc1-c1ccnn1C	InChI=1S/C26H28ClN5O2/c1-16-6-8-19(22-10-11-29-31(22)3)20(13-16)25(33)32-12-4-5-17(2)23(32)15-28-26-30-21-14-18(27)7-9-24(21)34-26/h6-11,13-14,17,23H,4-5,12,15H2,1-3H3,(H,28,30)/t17-,23-/m1/s1	XXEPGDPDPBZUTQ-UZUQRXQVSA-N	373314	((2S,3R)-2-(((5-Chlorobenzo[d]oxazol-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(1-methyl-1H-pyrazol-5-yl)phenyl)methanone::US9896452, Ex. A50	Orexin/Hypocretin receptor type 1	Homo sapiens		 230							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373314	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373314&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727681	404342413							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741120	C[C@@H]1CCCN([C@@H]1CNc1nc2cc(Cl)ccc2o1)C(=O)c1cc(C)ccc1-c1ccnn1C	InChI=1S/C26H28ClN5O2/c1-16-6-8-19(22-10-11-29-31(22)3)20(13-16)25(33)32-12-4-5-17(2)23(32)15-28-26-30-21-14-18(27)7-9-24(21)34-26/h6-11,13-14,17,23H,4-5,12,15H2,1-3H3,(H,28,30)/t17-,23-/m1/s1	XXEPGDPDPBZUTQ-UZUQRXQVSA-N	373314	((2S,3R)-2-(((5-Chlorobenzo[d]oxazol-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(1-methyl-1H-pyrazol-5-yl)phenyl)methanone::US9896452, Ex. A50	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373314	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373314&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727681	404342413							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741121	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C#N)C(=O)c1cc(C)ccc1-n1cnc(n1)C(F)(F)F	InChI=1S/C24H24F3N7O/c1-15-5-7-19(34-14-31-23(32-34)24(25,26)27)18(10-15)22(35)33-9-3-4-16(2)20(33)13-30-21-8-6-17(11-28)12-29-21/h5-8,10,12,14,16,20H,3-4,9,13H2,1-2H3,(H,29,30)/t16-,20-/m1/s1	KHRNHFQFDPSYCR-OXQOHEQNSA-N	373315	6-((((2S,3R)-3-Methyl-1-(5-methyl-2-(3-(trifluoromethyl)-1H-1,2,4-triazol-1-yl)benzoyl)piperidin-2-yl)methyl)amino)nicotinonitrile::US9896452, Ex. A51	Orexin/Hypocretin receptor type 1	Homo sapiens		>1000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373315	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373315&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727854	404342414							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741122	C[C@@H]1CCCN([C@@H]1CNc1ccc(F)cn1)C(=O)c1cc(C)ccc1-c1ccnc(C)c1	InChI=1S/C26H29FN4O/c1-17-6-8-22(20-10-11-28-19(3)14-20)23(13-17)26(32)31-12-4-5-18(2)24(31)16-30-25-9-7-21(27)15-29-25/h6-11,13-15,18,24H,4-5,12,16H2,1-3H3,(H,29,30)/t18-,24-/m1/s1	AUFITBVYOOFHJN-HOYKHHGWSA-N	373316	((2S,3R)-2-(((5-Fluoropyridin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(2-methylpyridin-4-yl)phenyl)methanone::US9896452, Ex. A53	Orexin/Hypocretin receptor type 1	Homo sapiens		 670							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373316	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373316&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728585	404342415							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741123	C[C@@H]1CCCN([C@@H]1CNc1ccc(F)cn1)C(=O)c1cc(C)ccc1-c1ccnc(C)c1	InChI=1S/C26H29FN4O/c1-17-6-8-22(20-10-11-28-19(3)14-20)23(13-17)26(32)31-12-4-5-18(2)24(31)16-30-25-9-7-21(27)15-29-25/h6-11,13-15,18,24H,4-5,12,16H2,1-3H3,(H,29,30)/t18-,24-/m1/s1	AUFITBVYOOFHJN-HOYKHHGWSA-N	373316	((2S,3R)-2-(((5-Fluoropyridin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(2-methylpyridin-4-yl)phenyl)methanone::US9896452, Ex. A53	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373316	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373316&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117728585	404342415							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741124	C[C@@H]1CCCN([C@@H]1CNc1ccc(C)cn1)C(=O)c1cc(C)ccc1-n1cnc(n1)C(F)(F)F	InChI=1S/C24H27F3N6O/c1-15-6-8-19(33-14-30-23(31-33)24(25,26)27)18(11-15)22(34)32-10-4-5-17(3)20(32)13-29-21-9-7-16(2)12-28-21/h6-9,11-12,14,17,20H,4-5,10,13H2,1-3H3,(H,28,29)/t17-,20-/m1/s1	IECDSJXFDVSLNJ-YLJYHZDGSA-N	373317	((2S,3R)-3-Methyl-2-(((5-methylpyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(3-(trifluoromethyl)-1H-1,2,4-triazol-1-yl)phenyl)methanone::US9896452, Ex. A56	Orexin/Hypocretin receptor type 1	Homo sapiens		>1000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373317	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373317&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727836	404342416							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741125	C[C@@H]1CCCN([C@@H]1CNc1ccc(F)cn1)C(=O)c1cc(C)ccc1-n1cnc(n1)C(F)(F)F	InChI=1S/C23H24F4N6O/c1-14-5-7-18(33-13-30-22(31-33)23(25,26)27)17(10-14)21(34)32-9-3-4-15(2)19(32)12-29-20-8-6-16(24)11-28-20/h5-8,10-11,13,15,19H,3-4,9,12H2,1-2H3,(H,28,29)/t15-,19-/m1/s1	CBBJSNPJDBTOCA-DNVCBOLYSA-N	373318	((2S,3R)-2-(((5-Fluoropyridin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(3-(trifluoromethyl)-1H-1,2,4-triazol-1-yl)phenyl)methanone::US9896452, Ex. A57	Orexin/Hypocretin receptor type 1	Homo sapiens		>1000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373318	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373318&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728086	404342417							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741126	C[C@@H]1CCCN([C@@H]1CNc1ccc(F)cn1)C(=O)c1cc(C)ccc1-c1ccccn1	InChI=1S/C25H27FN4O/c1-17-8-10-20(22-7-3-4-12-27-22)21(14-17)25(31)30-13-5-6-18(2)23(30)16-29-24-11-9-19(26)15-28-24/h3-4,7-12,14-15,18,23H,5-6,13,16H2,1-2H3,(H,28,29)/t18-,23-/m1/s1	IXSPJLXVFOXKFM-WZONZLPQSA-N	373319	((2S,3R)-2-(((5-Fluoropyridin-2-yl)amino)methyl)-3-methylpiperidin-1-yl) (5-methyl-2-(pyridin-2-yl)phenyl)methanone::US9896452, Ex. A58	Orexin/Hypocretin receptor type 1	Homo sapiens		 230							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373319	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373319&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728168	404342418							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741127	C[C@@H]1CCCN([C@@H]1CNc1ccc(F)cn1)C(=O)c1cc(C)ccc1-c1ccccn1	InChI=1S/C25H27FN4O/c1-17-8-10-20(22-7-3-4-12-27-22)21(14-17)25(31)30-13-5-6-18(2)23(30)16-29-24-11-9-19(26)15-28-24/h3-4,7-12,14-15,18,23H,5-6,13,16H2,1-2H3,(H,28,29)/t18-,23-/m1/s1	IXSPJLXVFOXKFM-WZONZLPQSA-N	373319	((2S,3R)-2-(((5-Fluoropyridin-2-yl)amino)methyl)-3-methylpiperidin-1-yl) (5-methyl-2-(pyridin-2-yl)phenyl)methanone::US9896452, Ex. A58	Orexin receptor type 2	Homo sapiens		 2400							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373319	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373319&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117728168	404342418							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741128	C[C@@H]1CCCN([C@@H]1CNc1ccc(C)cn1)C(=O)c1cc(C)ccc1-c1ccccn1	InChI=1S/C26H30N4O/c1-18-9-11-21(23-8-4-5-13-27-23)22(15-18)26(31)30-14-6-7-20(3)24(30)17-29-25-12-10-19(2)16-28-25/h4-5,8-13,15-16,20,24H,6-7,14,17H2,1-3H3,(H,28,29)/t20-,24-/m1/s1	FQWWSILNSMMOBB-HYBUGGRVSA-N	373320	((2S,3R)-3-Methyl-2-(((5-methylpyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(pyridin-2-yl)phenyl)methanone::US9896452, Ex. A59	Orexin/Hypocretin receptor type 1	Homo sapiens		 50.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373320	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373320&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728127	404342419							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741129	C[C@@H]1CCCN([C@@H]1CNc1ccc(C)cn1)C(=O)c1cc(C)ccc1-c1ccccn1	InChI=1S/C26H30N4O/c1-18-9-11-21(23-8-4-5-13-27-23)22(15-18)26(31)30-14-6-7-20(3)24(30)17-29-25-12-10-19(2)16-28-25/h4-5,8-13,15-16,20,24H,6-7,14,17H2,1-3H3,(H,28,29)/t20-,24-/m1/s1	FQWWSILNSMMOBB-HYBUGGRVSA-N	373320	((2S,3R)-3-Methyl-2-(((5-methylpyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(pyridin-2-yl)phenyl)methanone::US9896452, Ex. A59	Orexin receptor type 2	Homo sapiens		>2000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373320	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373320&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117728127	404342419							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741130	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C#N)C(=O)c1cc(C)ccc1-c1ccccn1	InChI=1S/C26H27N5O/c1-18-8-10-21(23-7-3-4-12-28-23)22(14-18)26(32)31-13-5-6-19(2)24(31)17-30-25-11-9-20(15-27)16-29-25/h3-4,7-12,14,16,19,24H,5-6,13,17H2,1-2H3,(H,29,30)/t19-,24-/m1/s1	MHCCELCMOQKEHD-NTKDMRAZSA-N	373321	6-((((2S,3R)-3-Methyl-1-(5-methyl-2-(pyridin-2-yl)benzoyl)piperidin-2-yl)methyl)amino)nicotinonitrile::US9896452, Ex. A60	Orexin/Hypocretin receptor type 1	Homo sapiens		 490							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373321	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373321&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728292	404342420							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741131	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C#N)C(=O)c1cc(C)ccc1-c1ccccn1	InChI=1S/C26H27N5O/c1-18-8-10-21(23-7-3-4-12-28-23)22(14-18)26(32)31-13-5-6-19(2)24(31)17-30-25-11-9-20(15-27)16-29-25/h3-4,7-12,14,16,19,24H,5-6,13,17H2,1-2H3,(H,29,30)/t19-,24-/m1/s1	MHCCELCMOQKEHD-NTKDMRAZSA-N	373321	6-((((2S,3R)-3-Methyl-1-(5-methyl-2-(pyridin-2-yl)benzoyl)piperidin-2-yl)methyl)amino)nicotinonitrile::US9896452, Ex. A60	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373321	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373321&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117728292	404342420							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741132	C[C@@H]1CCCN([C@@H]1CNc1ccc(F)cn1)C(=O)c1cc(C)ccc1-c1ccnn1C	InChI=1S/C24H28FN5O/c1-16-6-8-19(21-10-11-28-29(21)3)20(13-16)24(31)30-12-4-5-17(2)22(30)15-27-23-9-7-18(25)14-26-23/h6-11,13-14,17,22H,4-5,12,15H2,1-3H3,(H,26,27)/t17-,22-/m1/s1	ANVDBNYPYGFLDF-VGOFRKELSA-N	373322	((2S,3R)-2-(((5-Fluoropyridin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(1-methyl-1H-pyrazol-5-yl)phenyl)methanone::US9896452, Ex. A61	Orexin/Hypocretin receptor type 1	Homo sapiens		 1100							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373322	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373322&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728024	404342421							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741133	C[C@@H]1CCCN([C@@H]1CNc1ccc(F)cn1)C(=O)c1cc(C)ccc1-c1ccnn1C	InChI=1S/C24H28FN5O/c1-16-6-8-19(21-10-11-28-29(21)3)20(13-16)24(31)30-12-4-5-17(2)22(30)15-27-23-9-7-18(25)14-26-23/h6-11,13-14,17,22H,4-5,12,15H2,1-3H3,(H,26,27)/t17-,22-/m1/s1	ANVDBNYPYGFLDF-VGOFRKELSA-N	373322	((2S,3R)-2-(((5-Fluoropyridin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(1-methyl-1H-pyrazol-5-yl)phenyl)methanone::US9896452, Ex. A61	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373322	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373322&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117728024	404342421							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741134	C[C@@H]1CCCN([C@@H]1CNc1nc2cc(Cl)ccc2o1)C(=O)c1cc(C)ccc1-n1cnc(n1)C(F)(F)F	InChI=1S/C25H24ClF3N6O2/c1-14-5-7-19(35-13-31-23(33-35)25(27,28)29)17(10-14)22(36)34-9-3-4-15(2)20(34)12-30-24-32-18-11-16(26)6-8-21(18)37-24/h5-8,10-11,13,15,20H,3-4,9,12H2,1-2H3,(H,30,32)/t15-,20-/m1/s1	RIUNMLVVNMSMRT-FOIQADDNSA-N	373323	((2S,3R)-2-(((5-Chlorobenzo[d]oxazol-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(3-(trifluoromethyl)-1H-1,2,4-triazol-1-yl)phenyl)methanone::US9896452, Ex. A64	Orexin/Hypocretin receptor type 1	Homo sapiens		>1000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373323	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373323&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727889	404342422							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741135	C[C@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C24H24F4N4OS/c1-14-4-3-11-32(19(14)13-30-20-10-7-17(12-29-20)24(26,27)28)23(33)21-22(34-15(2)31-21)16-5-8-18(25)9-6-16/h5-10,12,14,19H,3-4,11,13H2,1-2H3,(H,29,30)/t14-,19+/m0/s1	SVCKMOGUOXOQCC-IFXJQAMLSA-N	373324	(5-(4-Fluorophenyl)-2-methylthiazol-4-yl)((2S,3S)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)methanone::US9896452, Ex. A65	Orexin/Hypocretin receptor type 1	Homo sapiens		 7.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373324	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373324&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727887	404342423							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741136	C[C@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C24H24F4N4OS/c1-14-4-3-11-32(19(14)13-30-20-10-7-17(12-29-20)24(26,27)28)23(33)21-22(34-15(2)31-21)16-5-8-18(25)9-6-16/h5-10,12,14,19H,3-4,11,13H2,1-2H3,(H,29,30)/t14-,19+/m0/s1	SVCKMOGUOXOQCC-IFXJQAMLSA-N	373324	(5-(4-Fluorophenyl)-2-methylthiazol-4-yl)((2S,3S)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)methanone::US9896452, Ex. A65	Orexin receptor type 2	Homo sapiens		 38.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373324	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373324&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727887	404342423							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741137	C[C@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1cc(C)ccc1-c1cnn(C)c1	InChI=1S/C25H28F3N5O/c1-16-6-8-20(18-12-31-32(3)15-18)21(11-16)24(34)33-10-4-5-17(2)22(33)14-30-23-9-7-19(13-29-23)25(26,27)28/h6-9,11-13,15,17,22H,4-5,10,14H2,1-3H3,(H,29,30)/t17-,22+/m0/s1	XHXUTIQEYCEZLE-HTAPYJJXSA-N	373325	((2S,3S)-3-Methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(1-methyl-1H-pyrazol-4-yl)phenyl)methanone::US9896452, Ex. A66	Orexin/Hypocretin receptor type 1	Homo sapiens		 150							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373325	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373325&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727805	404342424							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741138	C[C@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1cc(C)ccc1-c1cnn(C)c1	InChI=1S/C25H28F3N5O/c1-16-6-8-20(18-12-31-32(3)15-18)21(11-16)24(34)33-10-4-5-17(2)22(33)14-30-23-9-7-19(13-29-23)25(26,27)28/h6-9,11-13,15,17,22H,4-5,10,14H2,1-3H3,(H,29,30)/t17-,22+/m0/s1	XHXUTIQEYCEZLE-HTAPYJJXSA-N	373325	((2S,3S)-3-Methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(1-methyl-1H-pyrazol-4-yl)phenyl)methanone::US9896452, Ex. A66	Orexin receptor type 2	Homo sapiens		 2500							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373325	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373325&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727805	404342424							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741139	C[C@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1cc(C)ccc1-n1nccn1	InChI=1S/C23H25F3N6O/c1-15-5-7-19(32-29-9-10-30-32)18(12-15)22(33)31-11-3-4-16(2)20(31)14-28-21-8-6-17(13-27-21)23(24,25)26/h5-10,12-13,16,20H,3-4,11,14H2,1-2H3,(H,27,28)/t16-,20+/m0/s1	KTHFQWHOCBTIND-OXJNMPFZSA-N	373326	((2S,3S)-3-Methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A67	Orexin/Hypocretin receptor type 1	Homo sapiens		 6.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373326	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373326&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727748	404342425							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741140	C[C@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1cc(C)ccc1-n1nccn1	InChI=1S/C23H25F3N6O/c1-15-5-7-19(32-29-9-10-30-32)18(12-15)22(33)31-11-3-4-16(2)20(31)14-28-21-8-6-17(13-27-21)23(24,25)26/h5-10,12-13,16,20H,3-4,11,14H2,1-2H3,(H,27,28)/t16-,20+/m0/s1	KTHFQWHOCBTIND-OXJNMPFZSA-N	373326	((2S,3S)-3-Methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A67	Orexin receptor type 2	Homo sapiens		 130							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373326	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373326&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727748	404342425							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741141	Cc1ccc(c(c1)C(=O)N1CC2CCCC2C1CNc1ccc(cn1)C(F)(F)F)-n1nccn1	InChI=1S/C24H25F3N6O/c1-15-5-7-20(33-30-9-10-31-33)19(11-15)23(34)32-14-16-3-2-4-18(16)21(32)13-29-22-8-6-17(12-28-22)24(25,26)27/h5-12,16,18,21H,2-4,13-14H2,1H3,(H,28,29)	HDMRCFDSJOOFRM-UHFFFAOYSA-N	373327	(5-Methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)(1-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)methanone::US9896452, Ex. A69	Orexin/Hypocretin receptor type 1	Homo sapiens		 21.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373327	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373327&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89748145	404342426							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741142	Cc1ccc(c(c1)C(=O)N1CC2CCCC2C1CNc1ccc(cn1)C(F)(F)F)-n1nccn1	InChI=1S/C24H25F3N6O/c1-15-5-7-20(33-30-9-10-31-33)19(11-15)23(34)32-14-16-3-2-4-18(16)21(32)13-29-22-8-6-17(12-28-22)24(25,26)27/h5-12,16,18,21H,2-4,13-14H2,1H3,(H,28,29)	HDMRCFDSJOOFRM-UHFFFAOYSA-N	373327	(5-Methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)(1-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)methanone::US9896452, Ex. A69	Orexin receptor type 2	Homo sapiens		 1400							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373327	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373327&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			89748145	404342426							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741143	Cc1ccc(-c2cnn(C)c2)c(c1)C(=O)N1CC2CCCC2C1CNc1ccc(cn1)C(F)(F)F	InChI=1S/C26H28F3N5O/c1-16-6-8-20(18-11-32-33(2)14-18)22(10-16)25(35)34-15-17-4-3-5-21(17)23(34)13-31-24-9-7-19(12-30-24)26(27,28)29/h6-12,14,17,21,23H,3-5,13,15H2,1-2H3,(H,30,31)	NUMFDEALCNXBCG-UHFFFAOYSA-N	373328	(5-Methyl-2-(1-methyl-1H-pyrazol-4-yl)phenyl)(1-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)methanone::US9896452, Ex. A71	Orexin/Hypocretin receptor type 1	Homo sapiens		 70.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373328	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373328&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727879	404342427							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741144	Cc1ccc(-c2cnn(C)c2)c(c1)C(=O)N1CC2CCCC2C1CNc1ccc(cn1)C(F)(F)F	InChI=1S/C26H28F3N5O/c1-16-6-8-20(18-11-32-33(2)14-18)22(10-16)25(35)34-15-17-4-3-5-21(17)23(34)13-31-24-9-7-19(12-30-24)26(27,28)29/h6-12,14,17,21,23H,3-5,13,15H2,1-2H3,(H,30,31)	NUMFDEALCNXBCG-UHFFFAOYSA-N	373328	(5-Methyl-2-(1-methyl-1H-pyrazol-4-yl)phenyl)(1-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)methanone::US9896452, Ex. A71	Orexin receptor type 2	Homo sapiens		 3600							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373328	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373328&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727879	404342427							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741145	COc1c(F)cccc1C(=O)N1CCC[C@@H](C)[C@H]1CNc1ccc(cn1)C(F)(F)F	InChI=1S/C21H23F4N3O2/c1-13-5-4-10-28(20(29)15-6-3-7-16(22)19(15)30-2)17(13)12-27-18-9-8-14(11-26-18)21(23,24)25/h3,6-9,11,13,17H,4-5,10,12H2,1-2H3,(H,26,27)/t13-,17-/m1/s1	PMXGECKJQJOAPU-CXAGYDPISA-N	373329	(3-Fluoro-2-methoxyphenyl)((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)methanone::US9896452, Ex. A75	Orexin/Hypocretin receptor type 1	Homo sapiens		 1300							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373329	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373329&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727679	404342428							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741146	COc1c(F)cccc1C(=O)N1CCC[C@@H](C)[C@H]1CNc1ccc(cn1)C(F)(F)F	InChI=1S/C21H23F4N3O2/c1-13-5-4-10-28(20(29)15-6-3-7-16(22)19(15)30-2)17(13)12-27-18-9-8-14(11-26-18)21(23,24)25/h3,6-9,11,13,17H,4-5,10,12H2,1-2H3,(H,26,27)/t13-,17-/m1/s1	PMXGECKJQJOAPU-CXAGYDPISA-N	373329	(3-Fluoro-2-methoxyphenyl)((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)methanone::US9896452, Ex. A75	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373329	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373329&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727679	404342428							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741147	Cc1nc(C(=O)N2CCCC3CN(CC23)c2nc3ccc(Cl)cc3o2)c(s1)-c1ccc(F)cc1	InChI=1S/C25H22ClFN4O2S/c1-14-28-22(23(34-14)15-4-7-18(27)8-5-15)24(32)31-10-2-3-16-12-30(13-20(16)31)25-29-19-9-6-17(26)11-21(19)33-25/h4-9,11,16,20H,2-3,10,12-13H2,1H3	ZYWZQXJQBJKHFD-UHFFFAOYSA-N	373330	(6-(6-Chlorobenzo[d]oxazol-2-yl)octahydro-1H-pyrrolo[3,4-b]pyridin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone::US9896452, Ex. A76	Orexin/Hypocretin receptor type 1	Homo sapiens		>1000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373330	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373330&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727874	404342429							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741148	Cc1nc(C(=O)N2CCCC3CN(CC23)c2ccc(cn2)C(F)(F)F)c(s1)-c1ccc(F)cc1	InChI=1S/C24H22F4N4OS/c1-14-30-21(22(34-14)15-4-7-18(25)8-5-15)23(33)32-10-2-3-16-12-31(13-19(16)32)20-9-6-17(11-29-20)24(26,27)28/h4-9,11,16,19H,2-3,10,12-13H2,1H3	LABPJUZQHCCHNA-UHFFFAOYSA-N	373331	(5-(4-Fluorophenyl)-2-methylthiazol-4-yl)(6-(5-(trifluoromethyl)pyridin-2-yl)octahydro-1H-pyrrolo[3,4-b]pyridin-1-yl)methanone::US9896452, Ex. A77	Orexin/Hypocretin receptor type 1	Homo sapiens		>1000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373331	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373331&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727850	404342430							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741149	C[C@@H]1CCCN([C@@H]1CNc1ccc(Cl)cn1)C(=O)c1cc(C)ccc1-n1nccn1	InChI=1S/C22H25ClN6O/c1-15-5-7-19(29-26-9-10-27-29)18(12-15)22(30)28-11-3-4-16(2)20(28)14-25-21-8-6-17(23)13-24-21/h5-10,12-13,16,20H,3-4,11,14H2,1-2H3,(H,24,25)/t16-,20-/m1/s1	FWBPFEDJZUBSPO-OXQOHEQNSA-N	373332	((2S,3R)-2-(((5-Chloropyridin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A78	Orexin/Hypocretin receptor type 1	Homo sapiens		 7.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373332	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373332&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727653	404342431							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741150	C[C@@H]1CCCN([C@@H]1CNc1ccc(Cl)cn1)C(=O)c1cc(C)ccc1-n1nccn1	InChI=1S/C22H25ClN6O/c1-15-5-7-19(29-26-9-10-27-29)18(12-15)22(30)28-11-3-4-16(2)20(28)14-25-21-8-6-17(23)13-24-21/h5-10,12-13,16,20H,3-4,11,14H2,1-2H3,(H,24,25)/t16-,20-/m1/s1	FWBPFEDJZUBSPO-OXQOHEQNSA-N	373332	((2S,3R)-2-(((5-Chloropyridin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A78	Orexin receptor type 2	Homo sapiens		 2900							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373332	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373332&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727653	404342431							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741151	C[C@@H]1CCCN([C@@H]1CNc1cccc(C)n1)C(=O)c1cc(C)ccc1-n1nccn1	InChI=1S/C23H28N6O/c1-16-9-10-20(29-25-11-12-26-29)19(14-16)23(30)28-13-5-6-17(2)21(28)15-24-22-8-4-7-18(3)27-22/h4,7-12,14,17,21H,5-6,13,15H2,1-3H3,(H,24,27)/t17-,21-/m1/s1	FSNRUXQFZZRKHI-DYESRHJHSA-N	373333	((2S,3R)-3-Methyl-2-(((6-methylpyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A79	Orexin/Hypocretin receptor type 1	Homo sapiens		 310							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373333	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373333&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728171	404342432							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741152	C[C@@H]1CCCN([C@@H]1CNc1cccc(C)n1)C(=O)c1cc(C)ccc1-n1nccn1	InChI=1S/C23H28N6O/c1-16-9-10-20(29-25-11-12-26-29)19(14-16)23(30)28-13-5-6-17(2)21(28)15-24-22-8-4-7-18(3)27-22/h4,7-12,14,17,21H,5-6,13,15H2,1-3H3,(H,24,27)/t17-,21-/m1/s1	FSNRUXQFZZRKHI-DYESRHJHSA-N	373333	((2S,3R)-3-Methyl-2-(((6-methylpyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A79	Orexin receptor type 2	Homo sapiens		>4000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373333	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373333&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117728171	404342432							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741153	COc1cccc(NC[C@@H]2[C@H](C)CCCN2C(=O)c2cc(C)ccc2-n2nccn2)n1	InChI=1S/C23H28N6O2/c1-16-9-10-19(29-25-11-12-26-29)18(14-16)23(30)28-13-5-6-17(2)20(28)15-24-21-7-4-8-22(27-21)31-3/h4,7-12,14,17,20H,5-6,13,15H2,1-3H3,(H,24,27)/t17-,20-/m1/s1	IAFFMEPLGNDYNX-YLJYHZDGSA-N	373334	((2S,3R)-2-(((6-Methoxypyridin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A80	Orexin/Hypocretin receptor type 1	Homo sapiens		 1870							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373334	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373334&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728110	404342433							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741154	COc1cccc(NC[C@@H]2[C@H](C)CCCN2C(=O)c2cc(C)ccc2-n2nccn2)n1	InChI=1S/C23H28N6O2/c1-16-9-10-19(29-25-11-12-26-29)18(14-16)23(30)28-13-5-6-17(2)20(28)15-24-21-7-4-8-22(27-21)31-3/h4,7-12,14,17,20H,5-6,13,15H2,1-3H3,(H,24,27)/t17-,20-/m1/s1	IAFFMEPLGNDYNX-YLJYHZDGSA-N	373334	((2S,3R)-2-(((6-Methoxypyridin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A80	Orexin receptor type 2	Homo sapiens		>4000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373334	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373334&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117728110	404342433							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741155	C[C@@H]1CCCN([C@@H]1CNc1ncc(cc1F)C(F)(F)F)C(=O)c1cc(C)ccc1-n1nccn1	InChI=1S/C23H24F4N6O/c1-14-5-6-19(33-30-7-8-31-33)17(10-14)22(34)32-9-3-4-15(2)20(32)13-29-21-18(24)11-16(12-28-21)23(25,26)27/h5-8,10-12,15,20H,3-4,9,13H2,1-2H3,(H,28,29)/t15-,20-/m1/s1	ZGIXUPFDDFNPTE-FOIQADDNSA-N	373335	((2S,3R)-2-(((3-Fluoro-5-(trifluoromethyl)pyridin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A82	Orexin/Hypocretin receptor type 1	Homo sapiens		 8.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373335	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373335&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727746	404342434							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741156	C[C@@H]1CCCN([C@@H]1CNc1ncc(cc1F)C(F)(F)F)C(=O)c1cc(C)ccc1-n1nccn1	InChI=1S/C23H24F4N6O/c1-14-5-6-19(33-30-7-8-31-33)17(10-14)22(34)32-9-3-4-15(2)20(32)13-29-21-18(24)11-16(12-28-21)23(25,26)27/h5-8,10-12,15,20H,3-4,9,13H2,1-2H3,(H,28,29)/t15-,20-/m1/s1	ZGIXUPFDDFNPTE-FOIQADDNSA-N	373335	((2S,3R)-2-(((3-Fluoro-5-(trifluoromethyl)pyridin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A82	Orexin receptor type 2	Homo sapiens		 840							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373335	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373335&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727746	404342434							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741157	C[C@@H]1CCCN([C@@H]1CNc1nc2cc(Cl)ccc2o1)C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C25H24ClFN4O2S/c1-14-4-3-11-31(20(14)13-28-25-30-19-12-17(26)7-10-21(19)33-25)24(32)22-23(34-15(2)29-22)16-5-8-18(27)9-6-16/h5-10,12,14,20H,3-4,11,13H2,1-2H3,(H,28,30)/t14-,20-/m1/s1	CDQLBCDCGGHTKS-JLTOFOAXSA-N	373289	((2S,3R)-2-(((5-Chlorobenzo[d]oxazol-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone::US9896452, Ex. A13::US9896452, Ex. A84	Orexin/Hypocretin receptor type 1	Homo sapiens		 3.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373289	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373289&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727881	404342390							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741158	C[C@@H]1CCCN([C@@H]1CNc1nc2cc(Cl)ccc2o1)C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C25H24ClFN4O2S/c1-14-4-3-11-31(20(14)13-28-25-30-19-12-17(26)7-10-21(19)33-25)24(32)22-23(34-15(2)29-22)16-5-8-18(27)9-6-16/h5-10,12,14,20H,3-4,11,13H2,1-2H3,(H,28,30)/t14-,20-/m1/s1	CDQLBCDCGGHTKS-JLTOFOAXSA-N	373289	((2S,3R)-2-(((5-Chlorobenzo[d]oxazol-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone::US9896452, Ex. A13::US9896452, Ex. A84	Orexin receptor type 2	Homo sapiens		>4000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373289	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373289&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727881	404342390							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741159	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C24H24F4N4OS/c1-14-4-3-11-32(19(14)13-30-20-10-7-17(12-29-20)24(26,27)28)23(33)21-22(34-15(2)31-21)16-5-8-18(25)9-6-16/h5-10,12,14,19H,3-4,11,13H2,1-2H3,(H,29,30)/t14-,19-/m1/s1	SVCKMOGUOXOQCC-AUUYWEPGSA-N	373147	US9896452, Ex. A85::US9896452, Example 11::rac-(5-(4-fluorophenyl)-2-methylthiazol-4-yl)((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)methanone	Orexin/Hypocretin receptor type 1	Homo sapiens		 2.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373147	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373147&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89748213	404342251							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741160	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C24H24F4N4OS/c1-14-4-3-11-32(19(14)13-30-20-10-7-17(12-29-20)24(26,27)28)23(33)21-22(34-15(2)31-21)16-5-8-18(25)9-6-16/h5-10,12,14,19H,3-4,11,13H2,1-2H3,(H,29,30)/t14-,19-/m1/s1	SVCKMOGUOXOQCC-AUUYWEPGSA-N	373147	US9896452, Ex. A85::US9896452, Example 11::rac-(5-(4-fluorophenyl)-2-methylthiazol-4-yl)((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)methanone	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373147	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373147&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			89748213	404342251							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741161	C[C@@H]1CCCN([C@@H]1CNc1cccc(C)n1)C(=O)c1cc(C)ccc1-c1cnn(C)c1	InChI=1S/C25H31N5O/c1-17-10-11-21(20-14-27-29(4)16-20)22(13-17)25(31)30-12-6-7-18(2)23(30)15-26-24-9-5-8-19(3)28-24/h5,8-11,13-14,16,18,23H,6-7,12,15H2,1-4H3,(H,26,28)/t18-,23-/m1/s1	VDZSXMACWJKMBN-WZONZLPQSA-N	373339	((2S,3R)-3-Methyl-2-(((6-methylpyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(1-methyl-1H-pyrazol-4-yl)phenyl)methanone::US9896452, Ex. A87	Orexin/Hypocretin receptor type 1	Homo sapiens		 220							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373339	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373339&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728212	404342435							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741162	C[C@@H]1CCCN([C@@H]1CNc1cccc(C)n1)C(=O)c1cc(C)ccc1-c1cnn(C)c1	InChI=1S/C25H31N5O/c1-17-10-11-21(20-14-27-29(4)16-20)22(13-17)25(31)30-12-6-7-18(2)23(30)15-26-24-9-5-8-19(3)28-24/h5,8-11,13-14,16,18,23H,6-7,12,15H2,1-4H3,(H,26,28)/t18-,23-/m1/s1	VDZSXMACWJKMBN-WZONZLPQSA-N	373339	((2S,3R)-3-Methyl-2-(((6-methylpyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(1-methyl-1H-pyrazol-4-yl)phenyl)methanone::US9896452, Ex. A87	Orexin receptor type 2	Homo sapiens		>4000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373339	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373339&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117728212	404342435							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741163	C[C@@H]1CCCN([C@@H]1CNc1ncccc1C(F)(F)F)C(=O)c1cc(C)ccc1-n1nccn1	InChI=1S/C23H25F3N6O/c1-15-7-8-19(32-29-10-11-30-32)17(13-15)22(33)31-12-4-5-16(2)20(31)14-28-21-18(23(24,25)26)6-3-9-27-21/h3,6-11,13,16,20H,4-5,12,14H2,1-2H3,(H,27,28)/t16-,20-/m1/s1	RIEJJXQDXNLZKX-OXQOHEQNSA-N	373340	((2S,3R)-3-Methyl-2-(((3-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A88	Orexin/Hypocretin receptor type 1	Homo sapiens		 600							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373340	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373340&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728150	404342436							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741164	C[C@@H]1CCCN([C@@H]1CNc1ncccc1C(F)(F)F)C(=O)c1cc(C)ccc1-n1nccn1	InChI=1S/C23H25F3N6O/c1-15-7-8-19(32-29-10-11-30-32)17(13-15)22(33)31-12-4-5-16(2)20(31)14-28-21-18(23(24,25)26)6-3-9-27-21/h3,6-11,13,16,20H,4-5,12,14H2,1-2H3,(H,27,28)/t16-,20-/m1/s1	RIEJJXQDXNLZKX-OXQOHEQNSA-N	373340	((2S,3R)-3-Methyl-2-(((3-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A88	Orexin receptor type 2	Homo sapiens		 1800							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373340	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373340&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117728150	404342436							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741165	C[C@@H]1CCCN([C@@H]1CNc1ncccc1C#N)C(=O)c1cc(C)ccc1-n1nccn1	InChI=1S/C23H25N7O/c1-16-7-8-20(30-27-10-11-28-30)19(13-16)23(31)29-12-4-5-17(2)21(29)15-26-22-18(14-24)6-3-9-25-22/h3,6-11,13,17,21H,4-5,12,15H2,1-2H3,(H,25,26)/t17-,21-/m1/s1	WZFKGBDFEMXSHP-DYESRHJHSA-N	373341	2-((((2S,3R)-3-Methyl-1-(5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl)piperidin-2-yl)methyl)amino)nicotinonitrile::US9896452, Ex. A90	Orexin/Hypocretin receptor type 1	Homo sapiens		 360							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373341	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373341&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727990	404342437							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741166	C[C@@H]1CCCN([C@@H]1CNc1ncccc1C#N)C(=O)c1cc(C)ccc1-n1nccn1	InChI=1S/C23H25N7O/c1-16-7-8-20(30-27-10-11-28-30)19(13-16)23(31)29-12-4-5-17(2)21(29)15-26-22-18(14-24)6-3-9-25-22/h3,6-11,13,17,21H,4-5,12,15H2,1-2H3,(H,25,26)/t17-,21-/m1/s1	WZFKGBDFEMXSHP-DYESRHJHSA-N	373341	2-((((2S,3R)-3-Methyl-1-(5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl)piperidin-2-yl)methyl)amino)nicotinonitrile::US9896452, Ex. A90	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373341	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373341&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727990	404342437							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741167	C[C@@H]1CCCN([C@@H]1CNc1ncc(Cl)cc1F)C(=O)c1cc(C)ccc1-n1nccn1	InChI=1S/C22H24ClFN6O/c1-14-5-6-19(30-27-7-8-28-30)17(10-14)22(31)29-9-3-4-15(2)20(29)13-26-21-18(24)11-16(23)12-25-21/h5-8,10-12,15,20H,3-4,9,13H2,1-2H3,(H,25,26)/t15-,20-/m1/s1	GWUBJSOBJGIGBO-FOIQADDNSA-N	373342	((2S,3R)-2-(((5-Chloro-3-fluoropyridin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A173::US9896452, Ex. A92	Orexin/Hypocretin receptor type 1	Homo sapiens		 1.000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373342	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373342&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727654	404342438							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741168	C[C@@H]1CCCN([C@@H]1CNc1ncc(Cl)cc1F)C(=O)c1cc(C)ccc1-n1nccn1	InChI=1S/C22H24ClFN6O/c1-14-5-6-19(30-27-7-8-28-30)17(10-14)22(31)29-9-3-4-15(2)20(29)13-26-21-18(24)11-16(23)12-25-21/h5-8,10-12,15,20H,3-4,9,13H2,1-2H3,(H,25,26)/t15-,20-/m1/s1	GWUBJSOBJGIGBO-FOIQADDNSA-N	373342	((2S,3R)-2-(((5-Chloro-3-fluoropyridin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A173::US9896452, Ex. A92	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373342	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373342&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727654	404342438							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741169	C[C@@H]1CCCN([C@@H]1CNc1ncccc1C(F)(F)F)C(=O)c1cc(C)ccc1-c1cnn(C)c1	InChI=1S/C25H28F3N5O/c1-16-8-9-19(18-13-31-32(3)15-18)20(12-16)24(34)33-11-5-6-17(2)22(33)14-30-23-21(25(26,27)28)7-4-10-29-23/h4,7-10,12-13,15,17,22H,5-6,11,14H2,1-3H3,(H,29,30)/t17-,22-/m1/s1	JOSOKVYNZLGFLZ-VGOFRKELSA-N	373343	((2S,3R)-3-Methyl-2-(((3-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(1-methyl-1H-pyrazol-4-yl)phenyl)methanone::US9896452, Ex. A93	Orexin/Hypocretin receptor type 1	Homo sapiens		 460							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373343	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373343&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728126	404342439							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741170	C[C@@H]1CCCN([C@@H]1CNc1ncccc1C(F)(F)F)C(=O)c1cc(C)ccc1-c1cnn(C)c1	InChI=1S/C25H28F3N5O/c1-16-8-9-19(18-13-31-32(3)15-18)20(12-16)24(34)33-11-5-6-17(2)22(33)14-30-23-21(25(26,27)28)7-4-10-29-23/h4,7-10,12-13,15,17,22H,5-6,11,14H2,1-3H3,(H,29,30)/t17-,22-/m1/s1	JOSOKVYNZLGFLZ-VGOFRKELSA-N	373343	((2S,3R)-3-Methyl-2-(((3-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(1-methyl-1H-pyrazol-4-yl)phenyl)methanone::US9896452, Ex. A93	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373343	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373343&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117728126	404342439							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741171	C[C@@H]1CCCN([C@@H]1CNc1ncccc1C#N)C(=O)c1cc(C)ccc1-c1cnn(C)c1	InChI=1S/C25H28N6O/c1-17-8-9-21(20-14-29-30(3)16-20)22(12-17)25(32)31-11-5-6-18(2)23(31)15-28-24-19(13-26)7-4-10-27-24/h4,7-10,12,14,16,18,23H,5-6,11,15H2,1-3H3,(H,27,28)/t18-,23-/m1/s1	RAFCDHJQRLUETJ-WZONZLPQSA-N	373344	2-((((2S,3R)-3-Methyl-1-(5-methyl-2-(1-methyl-1H-pyrazol-4-yl)benzoyl)piperidin-2-yl)methyl)amino)nicotinonitrile::US9896452, Ex. A95	Orexin/Hypocretin receptor type 1	Homo sapiens		>1000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373344	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373344&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727691	404342440							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741172	COc1cccnc1NC[C@@H]1[C@H](C)CCCN1C(=O)c1cc(C)ccc1-n1nccn1	InChI=1S/C23H28N6O2/c1-16-8-9-19(29-26-11-12-27-29)18(14-16)23(30)28-13-5-6-17(2)20(28)15-25-22-21(31-3)7-4-10-24-22/h4,7-12,14,17,20H,5-6,13,15H2,1-3H3,(H,24,25)/t17-,20-/m1/s1	YQMANKIZJQTUNF-YLJYHZDGSA-N	373345	((2S,3R)-2-(((3-Methoxypyridin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A98	Orexin/Hypocretin receptor type 1	Homo sapiens		 270							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373345	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373345&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727821	404342441							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741173	COc1cccnc1NC[C@@H]1[C@H](C)CCCN1C(=O)c1cc(C)ccc1-n1nccn1	InChI=1S/C23H28N6O2/c1-16-8-9-19(29-26-11-12-27-29)18(14-16)23(30)28-13-5-6-17(2)20(28)15-25-22-21(31-3)7-4-10-24-22/h4,7-12,14,17,20H,5-6,13,15H2,1-3H3,(H,24,25)/t17-,20-/m1/s1	YQMANKIZJQTUNF-YLJYHZDGSA-N	373345	((2S,3R)-2-(((3-Methoxypyridin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A98	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373345	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373345&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727821	404342441							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741174	C[C@@H]1CCCN([C@@H]1CNc1ncccc1C)C(=O)c1cc(C)ccc1-n1nccn1	InChI=1S/C23H28N6O/c1-16-8-9-20(29-26-11-12-27-29)19(14-16)23(30)28-13-5-7-17(2)21(28)15-25-22-18(3)6-4-10-24-22/h4,6,8-12,14,17,21H,5,7,13,15H2,1-3H3,(H,24,25)/t17-,21-/m1/s1	XKZJPVPVPDMFOL-DYESRHJHSA-N	373346	((2S,3R)-3-Methyl-2-(((3-methylpyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A99	Orexin/Hypocretin receptor type 1	Homo sapiens		 340							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373346	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373346&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727923	404342442							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741175	C[C@@H]1CCCN([C@@H]1CNc1ncccc1C)C(=O)c1cc(C)ccc1-n1nccn1	InChI=1S/C23H28N6O/c1-16-8-9-20(29-26-11-12-27-29)19(14-16)23(30)28-13-5-7-17(2)21(28)15-25-22-18(3)6-4-10-24-22/h4,6,8-12,14,17,21H,5,7,13,15H2,1-3H3,(H,24,25)/t17-,21-/m1/s1	XKZJPVPVPDMFOL-DYESRHJHSA-N	373346	((2S,3R)-3-Methyl-2-(((3-methylpyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A99	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373346	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373346&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727923	404342442							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741176	C[C@@H]1CCCN([C@@H]1CNc1ncccc1C)C(=O)c1cc(C)ccc1-c1cnn(C)c1	InChI=1S/C25H31N5O/c1-17-9-10-21(20-14-28-29(4)16-20)22(13-17)25(31)30-12-6-8-18(2)23(30)15-27-24-19(3)7-5-11-26-24/h5,7,9-11,13-14,16,18,23H,6,8,12,15H2,1-4H3,(H,26,27)/t18-,23-/m1/s1	LDXOPLSEHAJAJY-WZONZLPQSA-N	373347	((2S,3R)-3-Methyl-2-(((3-methylpyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(1-methyl-1H-pyrazol-4-yl)phenyl)methanone::US9896452, Ex. A100	Orexin/Hypocretin receptor type 1	Homo sapiens		 1300							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373347	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373347&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727858	404342443							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741177	C[C@@H]1CCCN([C@@H]1CNc1ncccc1C)C(=O)c1cc(C)ccc1-c1cnn(C)c1	InChI=1S/C25H31N5O/c1-17-9-10-21(20-14-28-29(4)16-20)22(13-17)25(31)30-12-6-8-18(2)23(30)15-27-24-19(3)7-5-11-26-24/h5,7,9-11,13-14,16,18,23H,6,8,12,15H2,1-4H3,(H,26,27)/t18-,23-/m1/s1	LDXOPLSEHAJAJY-WZONZLPQSA-N	373347	((2S,3R)-3-Methyl-2-(((3-methylpyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(1-methyl-1H-pyrazol-4-yl)phenyl)methanone::US9896452, Ex. A100	Orexin receptor type 2	Homo sapiens		 1200							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373347	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373347&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727858	404342443							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741178	C[C@@H]1CCCN([C@@H]1CNc1nnc(s1)C(F)(F)F)C(=O)c1cc(C)ccc1-n1nccn1	InChI=1S/C20H22F3N7OS/c1-12-5-6-15(30-25-7-8-26-30)14(10-12)17(31)29-9-3-4-13(2)16(29)11-24-19-28-27-18(32-19)20(21,22)23/h5-8,10,13,16H,3-4,9,11H2,1-2H3,(H,24,28)/t13-,16-/m1/s1	VMQJZOOCIGLSKY-CZUORRHYSA-N	373348	((2S,3R)-3-Methyl-2-(((5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A102	Orexin/Hypocretin receptor type 1	Homo sapiens		 61.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373348	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373348&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727799	404342444							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741179	C[C@@H]1CCCN([C@@H]1CNc1nnc(s1)C(F)(F)F)C(=O)c1cc(C)ccc1-n1nccn1	InChI=1S/C20H22F3N7OS/c1-12-5-6-15(30-25-7-8-26-30)14(10-12)17(31)29-9-3-4-13(2)16(29)11-24-19-28-27-18(32-19)20(21,22)23/h5-8,10,13,16H,3-4,9,11H2,1-2H3,(H,24,28)/t13-,16-/m1/s1	VMQJZOOCIGLSKY-CZUORRHYSA-N	373348	((2S,3R)-3-Methyl-2-(((5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A102	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373348	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373348&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727799	404342444							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741180	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1cc(C)ccc1-c1cccc(C)n1	InChI=1S/C27H29F3N4O/c1-17-9-11-21(23-8-4-7-19(3)33-23)22(14-17)26(35)34-13-5-6-18(2)24(34)16-32-25-12-10-20(15-31-25)27(28,29)30/h4,7-12,14-15,18,24H,5-6,13,16H2,1-3H3,(H,31,32)/t18-,24-/m1/s1	WDRMYSCJKBOVSW-HOYKHHGWSA-N	373349	((2S,3R)-3-Methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(6-methylpyridin-2-yl)phenyl)methanone::US9896452, Ex. A104	Orexin/Hypocretin receptor type 1	Homo sapiens		 3.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373349	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373349&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89748268	404342445							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741181	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1cc(C)ccc1-c1cccc(C)n1	InChI=1S/C27H29F3N4O/c1-17-9-11-21(23-8-4-7-19(3)33-23)22(14-17)26(35)34-13-5-6-18(2)24(34)16-32-25-12-10-20(15-31-25)27(28,29)30/h4,7-12,14-15,18,24H,5-6,13,16H2,1-3H3,(H,31,32)/t18-,24-/m1/s1	WDRMYSCJKBOVSW-HOYKHHGWSA-N	373349	((2S,3R)-3-Methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(6-methylpyridin-2-yl)phenyl)methanone::US9896452, Ex. A104	Orexin receptor type 2	Homo sapiens		 1900							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373349	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373349&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			89748268	404342445							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741182	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1cc(C)ccc1-n1nccn1	InChI=1S/C23H25F3N6O/c1-15-5-7-19(32-29-9-10-30-32)18(12-15)22(33)31-11-3-4-16(2)20(31)14-28-21-8-6-17(13-27-21)23(24,25)26/h5-10,12-13,16,20H,3-4,11,14H2,1-2H3,(H,27,28)/t16-,20-/m1/s1	KTHFQWHOCBTIND-OXQOHEQNSA-N	373251	US9896452, Ex. A106::US9896452, Example 114::rac-((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone	Orexin/Hypocretin receptor type 1	Homo sapiens		 7.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373251	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373251&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89748160	404342353							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741183	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1cc(C)ccc1-n1nccn1	InChI=1S/C23H25F3N6O/c1-15-5-7-19(32-29-9-10-30-32)18(12-15)22(33)31-11-3-4-16(2)20(31)14-28-21-8-6-17(13-27-21)23(24,25)26/h5-10,12-13,16,20H,3-4,11,14H2,1-2H3,(H,27,28)/t16-,20-/m1/s1	KTHFQWHOCBTIND-OXQOHEQNSA-N	373251	US9896452, Ex. A106::US9896452, Example 114::rac-((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone	Orexin receptor type 2	Homo sapiens		 2300							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373251	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373251&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			89748160	404342353							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741184	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1cc(C)ccc1-n1cc(C)cn1	InChI=1S/C25H28F3N5O/c1-16-6-8-21(33-15-17(2)12-31-33)20(11-16)24(34)32-10-4-5-18(3)22(32)14-30-23-9-7-19(13-29-23)25(26,27)28/h6-9,11-13,15,18,22H,4-5,10,14H2,1-3H3,(H,29,30)/t18-,22-/m1/s1	OIOSLKQRWPKHHK-XMSQKQJNSA-N	373351	((2S,3R)-3-Methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(4-methyl-1H-pyrazol-1-yl)phenyl)methanone::US9896452, Ex. A107	Orexin/Hypocretin receptor type 1	Homo sapiens		 4.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373351	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373351&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727739	404342446							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741185	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1cc(C)ccc1-n1cc(C)cn1	InChI=1S/C25H28F3N5O/c1-16-6-8-21(33-15-17(2)12-31-33)20(11-16)24(34)32-10-4-5-18(3)22(32)14-30-23-9-7-19(13-29-23)25(26,27)28/h6-9,11-13,15,18,22H,4-5,10,14H2,1-3H3,(H,29,30)/t18-,22-/m1/s1	OIOSLKQRWPKHHK-XMSQKQJNSA-N	373351	((2S,3R)-3-Methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(4-methyl-1H-pyrazol-1-yl)phenyl)methanone::US9896452, Ex. A107	Orexin receptor type 2	Homo sapiens		 140							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373351	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373351&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727739	404342446							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741186	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1cc(C)ccc1-n1ccc(C)n1	InChI=1S/C25H28F3N5O/c1-16-6-8-21(33-12-10-18(3)31-33)20(13-16)24(34)32-11-4-5-17(2)22(32)15-30-23-9-7-19(14-29-23)25(26,27)28/h6-10,12-14,17,22H,4-5,11,15H2,1-3H3,(H,29,30)/t17-,22-/m1/s1	MZHLVUVPAFKQLO-VGOFRKELSA-N	373352	((2S,3R)-3-Methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(3-methyl-1H-pyrazol-1-yl)phenyl)methanone::US9896452, Ex. A108	Orexin/Hypocretin receptor type 1	Homo sapiens		 2.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373352	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373352&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89748172	404342447							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741187	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1cc(C)ccc1-n1ccc(C)n1	InChI=1S/C25H28F3N5O/c1-16-6-8-21(33-12-10-18(3)31-33)20(13-16)24(34)32-11-4-5-17(2)22(32)15-30-23-9-7-19(14-29-23)25(26,27)28/h6-10,12-14,17,22H,4-5,11,15H2,1-3H3,(H,29,30)/t17-,22-/m1/s1	MZHLVUVPAFKQLO-VGOFRKELSA-N	373352	((2S,3R)-3-Methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(3-methyl-1H-pyrazol-1-yl)phenyl)methanone::US9896452, Ex. A108	Orexin receptor type 2	Homo sapiens		 1800							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373352	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373352&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			89748172	404342447							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741188	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1nc(C)sc1-c1cccc(F)c1	InChI=1S/C24H24F4N4OS/c1-14-5-4-10-32(19(14)13-30-20-9-8-17(12-29-20)24(26,27)28)23(33)21-22(34-15(2)31-21)16-6-3-7-18(25)11-16/h3,6-9,11-12,14,19H,4-5,10,13H2,1-2H3,(H,29,30)/t14-,19-/m1/s1	MSTBQANRKVSXKE-AUUYWEPGSA-N	373353	(5-(3-Fluorophenyl)-2-methylthiazol-4-yl)((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)methanone::US9896452, Ex. A109	Orexin/Hypocretin receptor type 1	Homo sapiens		<10.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373353	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373353&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728506	404342448							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741189	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1nc(C)sc1-c1cccc(F)c1	InChI=1S/C24H24F4N4OS/c1-14-5-4-10-32(19(14)13-30-20-9-8-17(12-29-20)24(26,27)28)23(33)21-22(34-15(2)31-21)16-6-3-7-18(25)11-16/h3,6-9,11-12,14,19H,4-5,10,13H2,1-2H3,(H,29,30)/t14-,19-/m1/s1	MSTBQANRKVSXKE-AUUYWEPGSA-N	373353	(5-(3-Fluorophenyl)-2-methylthiazol-4-yl)((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)methanone::US9896452, Ex. A109	Orexin receptor type 2	Homo sapiens		>4000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373353	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373353&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117728506	404342448							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741190	CCn1cc(cn1)-c1ccc(C)cc1C(=O)N1CCC[C@@H](C)[C@H]1CNc1ccc(cn1)C(F)(F)F	InChI=1S/C26H30F3N5O/c1-4-33-16-19(13-32-33)21-9-7-17(2)12-22(21)25(35)34-11-5-6-18(3)23(34)15-31-24-10-8-20(14-30-24)26(27,28)29/h7-10,12-14,16,18,23H,4-6,11,15H2,1-3H3,(H,30,31)/t18-,23-/m1/s1	FSKFTFYIKWTLSH-WZONZLPQSA-N	373354	(2-(1-Ethyl-1H-pyrazol-4-yl)-5-methylphenyl)((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)methanone::US9896452, Ex. A110	Orexin/Hypocretin receptor type 1	Homo sapiens		 16.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373354	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373354&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727993	404342449							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741191	CCn1cc(cn1)-c1ccc(C)cc1C(=O)N1CCC[C@@H](C)[C@H]1CNc1ccc(cn1)C(F)(F)F	InChI=1S/C26H30F3N5O/c1-4-33-16-19(13-32-33)21-9-7-17(2)12-22(21)25(35)34-11-5-6-18(3)23(34)15-31-24-10-8-20(14-30-24)26(27,28)29/h7-10,12-14,16,18,23H,4-6,11,15H2,1-3H3,(H,30,31)/t18-,23-/m1/s1	FSKFTFYIKWTLSH-WZONZLPQSA-N	373354	(2-(1-Ethyl-1H-pyrazol-4-yl)-5-methylphenyl)((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)methanone::US9896452, Ex. A110	Orexin receptor type 2	Homo sapiens		 690							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373354	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373354&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727993	404342449							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741192	CC(C)n1cc(cn1)-c1ccc(C)cc1C(=O)N1CCC[C@@H](C)[C@H]1CNc1ccc(cn1)C(F)(F)F	InChI=1S/C27H32F3N5O/c1-17(2)35-16-20(13-33-35)22-9-7-18(3)12-23(22)26(36)34-11-5-6-19(4)24(34)15-32-25-10-8-21(14-31-25)27(28,29)30/h7-10,12-14,16-17,19,24H,5-6,11,15H2,1-4H3,(H,31,32)/t19-,24-/m1/s1	YNHXASVWSHWIRI-NTKDMRAZSA-N	373355	(2-(1-Isopropyl-1H-pyrazol-4-yl)-5-methylphenyl)((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)methanone::US9896452, Ex. A111	Orexin/Hypocretin receptor type 1	Homo sapiens		 17.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373355	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373355&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727723	404342450							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741193	CC(C)n1cc(cn1)-c1ccc(C)cc1C(=O)N1CCC[C@@H](C)[C@H]1CNc1ccc(cn1)C(F)(F)F	InChI=1S/C27H32F3N5O/c1-17(2)35-16-20(13-33-35)22-9-7-18(3)12-23(22)26(36)34-11-5-6-19(4)24(34)15-32-25-10-8-21(14-31-25)27(28,29)30/h7-10,12-14,16-17,19,24H,5-6,11,15H2,1-4H3,(H,31,32)/t19-,24-/m1/s1	YNHXASVWSHWIRI-NTKDMRAZSA-N	373355	(2-(1-Isopropyl-1H-pyrazol-4-yl)-5-methylphenyl)((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)methanone::US9896452, Ex. A111	Orexin receptor type 2	Homo sapiens		 860							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373355	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373355&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727723	404342450							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741194	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1cc(C)ccc1-n1ncc(C)n1	InChI=1S/C24H27F3N6O/c1-15-6-8-20(33-30-12-17(3)31-33)19(11-15)23(34)32-10-4-5-16(2)21(32)14-29-22-9-7-18(13-28-22)24(25,26)27/h6-9,11-13,16,21H,4-5,10,14H2,1-3H3,(H,28,29)/t16-,21-/m1/s1	QOUUKDQKZCPNRX-IIBYNOLFSA-N	373356	((2S,3R)-3-Methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(4-methyl-2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A112	Orexin/Hypocretin receptor type 1	Homo sapiens		 2.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373356	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373356&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727992	404342451							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741195	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1cc(C)ccc1-n1ncc(C)n1	InChI=1S/C24H27F3N6O/c1-15-6-8-20(33-30-12-17(3)31-33)19(11-15)23(34)32-10-4-5-16(2)21(32)14-29-22-9-7-18(13-28-22)24(25,26)27/h6-9,11-13,16,21H,4-5,10,14H2,1-3H3,(H,28,29)/t16-,21-/m1/s1	QOUUKDQKZCPNRX-IIBYNOLFSA-N	373356	((2S,3R)-3-Methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(4-methyl-2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A112	Orexin receptor type 2	Homo sapiens		 250							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373356	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373356&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727992	404342451							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741196	C[C@@H]1CCCN([C@@H]1COc1ccc(cn1)C(F)(F)F)C(=O)c1cc(C)ccc1-c1cnn(C)c1	InChI=1S/C25H27F3N4O2/c1-16-6-8-20(18-12-30-31(3)14-18)21(11-16)24(33)32-10-4-5-17(2)22(32)15-34-23-9-7-19(13-29-23)25(26,27)28/h6-9,11-14,17,22H,4-5,10,15H2,1-3H3/t17-,22-/m1/s1	SXXWINNBQHFSOH-VGOFRKELSA-N	373357	((2S,3R)-3-Methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)oxy)methyl)piperidin-1-yl)(5-methyl-2-(1-methyl-1H-pyrazol-4-yl)phenyl)methanone::US9896452, Ex. A114	Orexin/Hypocretin receptor type 1	Homo sapiens		>1000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373357	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373357&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727953	404342452							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741197	C[C@@H]1CCCN([C@@H]1CNc1nc2cc(Cl)ccc2o1)C(=O)c1cc(C)ccc1-n1ccc(C)n1	InChI=1S/C26H28ClN5O2/c1-16-6-8-22(32-12-10-18(3)30-32)20(13-16)25(33)31-11-4-5-17(2)23(31)15-28-26-29-21-14-19(27)7-9-24(21)34-26/h6-10,12-14,17,23H,4-5,11,15H2,1-3H3,(H,28,29)/t17-,23-/m1/s1	OHCBDURGBPHFFD-UZUQRXQVSA-N	373358	((2S,3R)-2-(((5-Chlorobenzo[d]oxazol-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(3-methyl-1H-pyrazol-1-yl)phenyl)methanone::US9896452, Ex. A115	Orexin/Hypocretin receptor type 1	Homo sapiens		 16.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373358	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373358&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728081	404342453							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741198	C[C@@H]1CCCN([C@@H]1CNc1nc2cc(Cl)ccc2o1)C(=O)c1cc(C)ccc1-n1ccc(C)n1	InChI=1S/C26H28ClN5O2/c1-16-6-8-22(32-12-10-18(3)30-32)20(13-16)25(33)31-11-4-5-17(2)23(31)15-28-26-29-21-14-19(27)7-9-24(21)34-26/h6-10,12-14,17,23H,4-5,11,15H2,1-3H3,(H,28,29)/t17-,23-/m1/s1	OHCBDURGBPHFFD-UZUQRXQVSA-N	373358	((2S,3R)-2-(((5-Chlorobenzo[d]oxazol-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(3-methyl-1H-pyrazol-1-yl)phenyl)methanone::US9896452, Ex. A115	Orexin receptor type 2	Homo sapiens		>4000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373358	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373358&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117728081	404342453							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741199	C[C@@H]1CCCN([C@@H]1CNc1nc2cc(Cl)ccc2o1)C(=O)c1cc(C)ccc1-n1ncc(C)n1	InChI=1S/C25H27ClN6O2/c1-15-6-8-21(32-28-13-17(3)30-32)19(11-15)24(33)31-10-4-5-16(2)22(31)14-27-25-29-20-12-18(26)7-9-23(20)34-25/h6-9,11-13,16,22H,4-5,10,14H2,1-3H3,(H,27,29)/t16-,22-/m1/s1	LGAFETZZZJRZJI-OPAMFIHVSA-N	373359	((2S,3R)-2-(((5-Chlorobenzo[d]oxazol-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(4-methyl-2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A116	Orexin/Hypocretin receptor type 1	Homo sapiens		 4.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373359	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373359&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727949	404342454							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741200	C[C@@H]1CCCN([C@@H]1CNc1nc2cc(Cl)ccc2o1)C(=O)c1cc(C)ccc1-n1ncc(C)n1	InChI=1S/C25H27ClN6O2/c1-15-6-8-21(32-28-13-17(3)30-32)19(11-15)24(33)31-10-4-5-16(2)22(31)14-27-25-29-20-12-18(26)7-9-23(20)34-25/h6-9,11-13,16,22H,4-5,10,14H2,1-3H3,(H,27,29)/t16-,22-/m1/s1	LGAFETZZZJRZJI-OPAMFIHVSA-N	373359	((2S,3R)-2-(((5-Chlorobenzo[d]oxazol-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(4-methyl-2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A116	Orexin receptor type 2	Homo sapiens		 1100							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373359	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373359&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727949	404342454							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741201	C[C@@H]1CCCN([C@@H]1CNc1ccc(Cl)cn1)C(=O)c1cc(C)ccc1-c1ccccn1	InChI=1S/C25H27ClN4O/c1-17-8-10-20(22-7-3-4-12-27-22)21(14-17)25(31)30-13-5-6-18(2)23(30)16-29-24-11-9-19(26)15-28-24/h3-4,7-12,14-15,18,23H,5-6,13,16H2,1-2H3,(H,28,29)/t18-,23-/m1/s1	QHIHMDSFZZWWEF-WZONZLPQSA-N	373360	((2S,3R)-2-(((5-chloropyridin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(pyridin-2-yl)phenyl)methanone::US9896452, Ex. A117	Orexin/Hypocretin receptor type 1	Homo sapiens		 37.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373360	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373360&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727711	404342455							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741202	C[C@@H]1CCCN([C@@H]1CNc1ccc(Cl)cn1)C(=O)c1cc(C)ccc1-c1ccccn1	InChI=1S/C25H27ClN4O/c1-17-8-10-20(22-7-3-4-12-27-22)21(14-17)25(31)30-13-5-6-18(2)23(30)16-29-24-11-9-19(26)15-28-24/h3-4,7-12,14-15,18,23H,5-6,13,16H2,1-2H3,(H,28,29)/t18-,23-/m1/s1	QHIHMDSFZZWWEF-WZONZLPQSA-N	373360	((2S,3R)-2-(((5-chloropyridin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(pyridin-2-yl)phenyl)methanone::US9896452, Ex. A117	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373360	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373360&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727711	404342455							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741203	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1cc(C)ccc1-c1ccc(C)cn1	InChI=1S/C27H29F3N4O/c1-17-6-9-21(23-10-7-18(2)14-31-23)22(13-17)26(35)34-12-4-5-19(3)24(34)16-33-25-11-8-20(15-32-25)27(28,29)30/h6-11,13-15,19,24H,4-5,12,16H2,1-3H3,(H,32,33)/t19-,24-/m1/s1	UZLPTWNVMJUCDE-NTKDMRAZSA-N	373361	((2S,3R)-3-Methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(5-methylpyridin-2-yl)phenyl)methanone::US9896452, Ex. A118	Orexin/Hypocretin receptor type 1	Homo sapiens		 15.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373361	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373361&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727677	404342456							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741204	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1cc(C)ccc1-c1ccc(C)cn1	InChI=1S/C27H29F3N4O/c1-17-6-9-21(23-10-7-18(2)14-31-23)22(13-17)26(35)34-12-4-5-19(3)24(34)16-33-25-11-8-20(15-32-25)27(28,29)30/h6-11,13-15,19,24H,4-5,12,16H2,1-3H3,(H,32,33)/t19-,24-/m1/s1	UZLPTWNVMJUCDE-NTKDMRAZSA-N	373361	((2S,3R)-3-Methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(5-methylpyridin-2-yl)phenyl)methanone::US9896452, Ex. A118	Orexin receptor type 2	Homo sapiens		 2200							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373361	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373361&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727677	404342456							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741205	C[C@@H]1CCCN([C@@H]1CNc1ccc(nn1)C(F)(F)F)C(=O)c1cc(C)ccc1-n1nccn1	InChI=1S/C22H24F3N7O/c1-14-5-6-17(32-27-9-10-28-32)16(12-14)21(33)31-11-3-4-15(2)18(31)13-26-20-8-7-19(29-30-20)22(23,24)25/h5-10,12,15,18H,3-4,11,13H2,1-2H3,(H,26,30)/t15-,18-/m1/s1	IBWMCOCDXCSZPF-CRAIPNDOSA-N	373362	((2S,3R)-3-Methyl-2-(((6-(trifluoromethyl)pyridazin-3-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A119	Orexin/Hypocretin receptor type 1	Homo sapiens		 19.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373362	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373362&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727979	404342457							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741206	C[C@@H]1CCCN([C@@H]1CNc1ccc(nn1)C(F)(F)F)C(=O)c1cc(C)ccc1-n1nccn1	InChI=1S/C22H24F3N7O/c1-14-5-6-17(32-27-9-10-28-32)16(12-14)21(33)31-11-3-4-15(2)18(31)13-26-20-8-7-19(29-30-20)22(23,24)25/h5-10,12,15,18H,3-4,11,13H2,1-2H3,(H,26,30)/t15-,18-/m1/s1	IBWMCOCDXCSZPF-CRAIPNDOSA-N	373362	((2S,3R)-3-Methyl-2-(((6-(trifluoromethyl)pyridazin-3-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A119	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373362	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373362&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727979	404342457							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741207	C[C@@H]1CCCN([C@@H]1CNc1ccc(Cl)cn1)C(=O)c1cc(C)ccc1-n1ccc(C)n1	InChI=1S/C24H28ClN5O/c1-16-6-8-21(30-12-10-18(3)28-30)20(13-16)24(31)29-11-4-5-17(2)22(29)15-27-23-9-7-19(25)14-26-23/h6-10,12-14,17,22H,4-5,11,15H2,1-3H3,(H,26,27)/t17-,22-/m1/s1	JAJHINXXZXEHPT-VGOFRKELSA-N	373363	((2S,3R)-2-(((5-Chloropyridin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(3-methyl-1H-pyrazol-1-yl)phenyl)methanone::US9896452, Ex. A120	Orexin/Hypocretin receptor type 1	Homo sapiens		 21.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373363	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373363&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727975	404342458							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741208	C[C@@H]1CCCN([C@@H]1CNc1ccc(Cl)cn1)C(=O)c1cc(C)ccc1-n1ccc(C)n1	InChI=1S/C24H28ClN5O/c1-16-6-8-21(30-12-10-18(3)28-30)20(13-16)24(31)29-11-4-5-17(2)22(29)15-27-23-9-7-19(25)14-26-23/h6-10,12-14,17,22H,4-5,11,15H2,1-3H3,(H,26,27)/t17-,22-/m1/s1	JAJHINXXZXEHPT-VGOFRKELSA-N	373363	((2S,3R)-2-(((5-Chloropyridin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(3-methyl-1H-pyrazol-1-yl)phenyl)methanone::US9896452, Ex. A120	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373363	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373363&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727975	404342458							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741209	C[C@@H]1CCCN([C@@H]1CNc1ccc(Cl)cn1)C(=O)c1cc(C)ccc1-n1ncc(C)n1	InChI=1S/C23H27ClN6O/c1-15-6-8-20(30-27-12-17(3)28-30)19(11-15)23(31)29-10-4-5-16(2)21(29)14-26-22-9-7-18(24)13-25-22/h6-9,11-13,16,21H,4-5,10,14H2,1-3H3,(H,25,26)/t16-,21-/m1/s1	SFYBTDUEJRTOHZ-IIBYNOLFSA-N	373364	((2S,3R)-2-(((5-Chloropyridin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(4-methyl-2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A121	Orexin/Hypocretin receptor type 1	Homo sapiens		 5.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373364	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373364&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728142	404342459							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741210	C[C@@H]1CCCN([C@@H]1CNc1ccc(Cl)cn1)C(=O)c1cc(C)ccc1-n1ncc(C)n1	InChI=1S/C23H27ClN6O/c1-15-6-8-20(30-27-12-17(3)28-30)19(11-15)23(31)29-10-4-5-16(2)21(29)14-26-22-9-7-18(24)13-25-22/h6-9,11-13,16,21H,4-5,10,14H2,1-3H3,(H,25,26)/t16-,21-/m1/s1	SFYBTDUEJRTOHZ-IIBYNOLFSA-N	373364	((2S,3R)-2-(((5-Chloropyridin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(4-methyl-2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A121	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373364	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373364&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117728142	404342459							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741211	C[C@@H]1CCCN([C@@H]1CNc1ncc2cc(Br)ccc2n1)C(=O)c1cc(C)ccc1-n1nccn1	InChI=1S/C25H26BrN7O/c1-16-5-8-22(33-29-9-10-30-33)20(12-16)24(34)32-11-3-4-17(2)23(32)15-28-25-27-14-18-13-19(26)6-7-21(18)31-25/h5-10,12-14,17,23H,3-4,11,15H2,1-2H3,(H,27,28,31)/t17-,23-/m1/s1	JQPRDDIADOXCIN-UZUQRXQVSA-N	373365	((2S,3R)-2-(((6-Bromoquinazolin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A122	Orexin/Hypocretin receptor type 1	Homo sapiens		 96.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373365	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373365&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727971	404342460							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741212	C[C@@H]1CCCN([C@@H]1CNc1ncc2cc(Br)ccc2n1)C(=O)c1cc(C)ccc1-n1nccn1	InChI=1S/C25H26BrN7O/c1-16-5-8-22(33-29-9-10-30-33)20(12-16)24(34)32-11-3-4-17(2)23(32)15-28-25-27-14-18-13-19(26)6-7-21(18)31-25/h5-10,12-14,17,23H,3-4,11,15H2,1-2H3,(H,27,28,31)/t17-,23-/m1/s1	JQPRDDIADOXCIN-UZUQRXQVSA-N	373365	((2S,3R)-2-(((6-Bromoquinazolin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A122	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373365	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373365&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727971	404342460							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741213	C[C@@H]1CCCN([C@@H]1CNc1nc(cs1)C(F)(F)F)C(=O)c1cc(C)ccc1-n1nccn1	InChI=1S/C21H23F3N6OS/c1-13-5-6-16(30-26-7-8-27-30)15(10-13)19(31)29-9-3-4-14(2)17(29)11-25-20-28-18(12-32-20)21(22,23)24/h5-8,10,12,14,17H,3-4,9,11H2,1-2H3,(H,25,28)/t14-,17-/m1/s1	MPFRTOANWDWLDZ-RHSMWYFYSA-N	373366	((2S,3R)-3-Methyl-2-(((4-(trifluoromethyl)thiazol-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A123	Orexin/Hypocretin receptor type 1	Homo sapiens		 410							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373366	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373366&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727709	404342461							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741214	C[C@@H]1CCCN([C@@H]1CNc1nc(cs1)C(F)(F)F)C(=O)c1cc(C)ccc1-n1nccn1	InChI=1S/C21H23F3N6OS/c1-13-5-6-16(30-26-7-8-27-30)15(10-13)19(31)29-9-3-4-14(2)17(29)11-25-20-28-18(12-32-20)21(22,23)24/h5-8,10,12,14,17H,3-4,9,11H2,1-2H3,(H,25,28)/t14-,17-/m1/s1	MPFRTOANWDWLDZ-RHSMWYFYSA-N	373366	((2S,3R)-3-Methyl-2-(((4-(trifluoromethyl)thiazol-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A123	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373366	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373366&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727709	404342461							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741215	C[C@@H]1CCCN([C@@H]1CNc1ccc(nn1)C(F)(F)F)C(=O)c1cc(C)ccc1-n1ncc(C)n1	InChI=1S/C23H26F3N7O/c1-14-6-7-18(33-28-12-16(3)31-33)17(11-14)22(34)32-10-4-5-15(2)19(32)13-27-21-9-8-20(29-30-21)23(24,25)26/h6-9,11-12,15,19H,4-5,10,13H2,1-3H3,(H,27,30)/t15-,19-/m1/s1	LPRGLXHHIKAPCG-DNVCBOLYSA-N	373367	((2S,3R)-3-methyl-2-(((6-(trifluoromethyl)pyridazin-3-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(4-methyl-2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A125	Orexin/Hypocretin receptor type 1	Homo sapiens		 25.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373367	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373367&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728228	404342462							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741216	C[C@@H]1CCCN([C@@H]1CNc1ccc(nn1)C(F)(F)F)C(=O)c1cc(C)ccc1-n1ncc(C)n1	InChI=1S/C23H26F3N7O/c1-14-6-7-18(33-28-12-16(3)31-33)17(11-14)22(34)32-10-4-5-15(2)19(32)13-27-21-9-8-20(29-30-21)23(24,25)26/h6-9,11-12,15,19H,4-5,10,13H2,1-3H3,(H,27,30)/t15-,19-/m1/s1	LPRGLXHHIKAPCG-DNVCBOLYSA-N	373367	((2S,3R)-3-methyl-2-(((6-(trifluoromethyl)pyridazin-3-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(4-methyl-2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A125	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373367	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373367&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117728228	404342462							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741217	COc1ccc(NC[C@@H]2[C@H](C)CCCN2C(=O)c2cc(C)ccc2-n2nccn2)nc1	InChI=1S/C23H28N6O2/c1-16-6-8-20(29-26-10-11-27-29)19(13-16)23(30)28-12-4-5-17(2)21(28)15-25-22-9-7-18(31-3)14-24-22/h6-11,13-14,17,21H,4-5,12,15H2,1-3H3,(H,24,25)/t17-,21-/m1/s1	DDIJLMRKHNYNEO-DYESRHJHSA-N	373368	((2S,3R)-2-(((5-Methoxypyridin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A126	Orexin/Hypocretin receptor type 1	Homo sapiens		 43.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373368	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373368&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727619	404342463							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741218	COc1ccc(NC[C@@H]2[C@H](C)CCCN2C(=O)c2cc(C)ccc2-n2nccn2)nc1	InChI=1S/C23H28N6O2/c1-16-6-8-20(29-26-10-11-27-29)19(13-16)23(30)28-12-4-5-17(2)21(28)15-25-22-9-7-18(31-3)14-24-22/h6-11,13-14,17,21H,4-5,12,15H2,1-3H3,(H,24,25)/t17-,21-/m1/s1	DDIJLMRKHNYNEO-DYESRHJHSA-N	373368	((2S,3R)-2-(((5-Methoxypyridin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A126	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373368	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373368&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727619	404342463							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741219	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C#N)C(=O)c1cc(C)ccc1-n1nccn1	InChI=1S/C23H25N7O/c1-16-5-7-20(30-27-9-10-28-30)19(12-16)23(31)29-11-3-4-17(2)21(29)15-26-22-8-6-18(13-24)14-25-22/h5-10,12,14,17,21H,3-4,11,15H2,1-2H3,(H,25,26)/t17-,21-/m1/s1	MGSGNMUJJXUGRQ-DYESRHJHSA-N	373309	6-((((2S,3R)-3-Methyl-1-(5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl)piperidin-2-yl)methyl)amino)nicotinonitrile::US9896452, Ex. A127::US9896452, Ex. A46	Orexin/Hypocretin receptor type 1	Homo sapiens		 5.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373309	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373309&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727834	404342409							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741220	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C#N)C(=O)c1cc(C)ccc1-n1nccn1	InChI=1S/C23H25N7O/c1-16-5-7-20(30-27-9-10-28-30)19(12-16)23(31)29-11-3-4-17(2)21(29)15-26-22-8-6-18(13-24)14-25-22/h5-10,12,14,17,21H,3-4,11,15H2,1-2H3,(H,25,26)/t17-,21-/m1/s1	MGSGNMUJJXUGRQ-DYESRHJHSA-N	373309	6-((((2S,3R)-3-Methyl-1-(5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl)piperidin-2-yl)methyl)amino)nicotinonitrile::US9896452, Ex. A127::US9896452, Ex. A46	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373309	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373309&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727834	404342409							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741221	C[C@@H]1CCCN([C@@H]1CNc1nc2cc(F)ccc2o1)C(=O)c1cc(C)ccc1-n1nccn1	InChI=1S/C24H25FN6O2/c1-15-5-7-20(31-27-9-10-28-31)18(12-15)23(32)30-11-3-4-16(2)21(30)14-26-24-29-19-13-17(25)6-8-22(19)33-24/h5-10,12-13,16,21H,3-4,11,14H2,1-2H3,(H,26,29)/t16-,21-/m1/s1	XYJCAEKTDPOHKG-IIBYNOLFSA-N	373370	((2S,3R)-2-(((5-Fluorobenzo[d]oxazol-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A129	Orexin/Hypocretin receptor type 1	Homo sapiens		 3.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373370	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373370&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728163	404342464							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741222	C[C@@H]1CCCN([C@@H]1CNc1nc2cc(F)ccc2o1)C(=O)c1cc(C)ccc1-n1nccn1	InChI=1S/C24H25FN6O2/c1-15-5-7-20(31-27-9-10-28-31)18(12-15)23(32)30-11-3-4-16(2)21(30)14-26-24-29-19-13-17(25)6-8-22(19)33-24/h5-10,12-13,16,21H,3-4,11,14H2,1-2H3,(H,26,29)/t16-,21-/m1/s1	XYJCAEKTDPOHKG-IIBYNOLFSA-N	373370	((2S,3R)-2-(((5-Fluorobenzo[d]oxazol-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A129	Orexin receptor type 2	Homo sapiens		 100.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373370	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373370&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117728163	404342464							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741223	C[C@@H]1CCCN([C@@H]1CNc1ccc(nn1)C(F)(F)F)C(=O)c1cc(C)ccc1-n1ccc(C)n1	InChI=1S/C24H27F3N6O/c1-15-6-7-19(33-12-10-17(3)31-33)18(13-15)23(34)32-11-4-5-16(2)20(32)14-28-22-9-8-21(29-30-22)24(25,26)27/h6-10,12-13,16,20H,4-5,11,14H2,1-3H3,(H,28,30)/t16-,20-/m1/s1	ZJJGGJYYZRBGGN-OXQOHEQNSA-N	373371	((2S,3R)-3-Methyl-2-(((6-(trifluoromethyl)pyridazin-3-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(3-methyl-1H-pyrazol-1-yl)phenyl)methanone::US9896452, Ex. A130	Orexin/Hypocretin receptor type 1	Homo sapiens		 21.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373371	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373371&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727701	404342465							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741224	C[C@@H]1CCCN([C@@H]1CNc1ccc(nn1)C(F)(F)F)C(=O)c1cc(C)ccc1-n1ccc(C)n1	InChI=1S/C24H27F3N6O/c1-15-6-7-19(33-12-10-17(3)31-33)18(13-15)23(34)32-11-4-5-16(2)20(32)14-28-22-9-8-21(29-30-22)24(25,26)27/h6-10,12-13,16,20H,4-5,11,14H2,1-3H3,(H,28,30)/t16-,20-/m1/s1	ZJJGGJYYZRBGGN-OXQOHEQNSA-N	373371	((2S,3R)-3-Methyl-2-(((6-(trifluoromethyl)pyridazin-3-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(3-methyl-1H-pyrazol-1-yl)phenyl)methanone::US9896452, Ex. A130	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373371	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373371&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727701	404342465							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741225	C[C@@H]1CCCN([C@@H]1CNc1ncc(cn1)C#N)C(=O)c1cc(C)ccc1-n1ccc(C)n1	InChI=1S/C24H27N7O/c1-16-6-7-21(31-10-8-18(3)29-31)20(11-16)23(32)30-9-4-5-17(2)22(30)15-28-24-26-13-19(12-25)14-27-24/h6-8,10-11,13-14,17,22H,4-5,9,15H2,1-3H3,(H,26,27,28)/t17-,22-/m1/s1	KLNKUBNTJYXQPL-VGOFRKELSA-N	373372	2-((((2S,3R)-3-Methyl-1-(5-methyl-2-(3-methyl-1H-pyrazol-1-yl)benzoyl)piperidin-2-yl)methyl)amino)pyrimidine-5-carbonitrile::US9896452, Ex. A131	Orexin/Hypocretin receptor type 1	Homo sapiens		 20.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373372	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373372&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728484	404342466							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741226	C[C@@H]1CCCN([C@@H]1CNc1ncc(cn1)C#N)C(=O)c1cc(C)ccc1-n1ccc(C)n1	InChI=1S/C24H27N7O/c1-16-6-7-21(31-10-8-18(3)29-31)20(11-16)23(32)30-9-4-5-17(2)22(30)15-28-24-26-13-19(12-25)14-27-24/h6-8,10-11,13-14,17,22H,4-5,9,15H2,1-3H3,(H,26,27,28)/t17-,22-/m1/s1	KLNKUBNTJYXQPL-VGOFRKELSA-N	373372	2-((((2S,3R)-3-Methyl-1-(5-methyl-2-(3-methyl-1H-pyrazol-1-yl)benzoyl)piperidin-2-yl)methyl)amino)pyrimidine-5-carbonitrile::US9896452, Ex. A131	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373372	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373372&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117728484	404342466							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741227	C[C@@H]1CCCN([C@@H]1CNc1nnc(s1)C(F)(F)F)C(=O)c1cc(C)ccc1-n1ccc(C)n1	InChI=1S/C22H25F3N6OS/c1-13-6-7-17(31-10-8-15(3)29-31)16(11-13)19(32)30-9-4-5-14(2)18(30)12-26-21-28-27-20(33-21)22(23,24)25/h6-8,10-11,14,18H,4-5,9,12H2,1-3H3,(H,26,28)/t14-,18-/m1/s1	KOTYWCBPAIQSPY-RDTXWAMCSA-N	373373	((2S,3R)-3-Methyl-2-(((5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(3-methyl-1H-pyrazol-1-yl)phenyl)methanone::US9896452, Ex. A132	Orexin/Hypocretin receptor type 1	Homo sapiens		 160							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373373	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373373&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728274	404342467							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741228	C[C@@H]1CCCN([C@@H]1CNc1nnc(s1)C(F)(F)F)C(=O)c1cc(C)ccc1-n1ccc(C)n1	InChI=1S/C22H25F3N6OS/c1-13-6-7-17(31-10-8-15(3)29-31)16(11-13)19(32)30-9-4-5-14(2)18(30)12-26-21-28-27-20(33-21)22(23,24)25/h6-8,10-11,14,18H,4-5,9,12H2,1-3H3,(H,26,28)/t14-,18-/m1/s1	KOTYWCBPAIQSPY-RDTXWAMCSA-N	373373	((2S,3R)-3-Methyl-2-(((5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(3-methyl-1H-pyrazol-1-yl)phenyl)methanone::US9896452, Ex. A132	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373373	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373373&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117728274	404342467							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741229	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C#N)C(=O)c1cc(C)ccc1-n1ccc(C)n1	InChI=1S/C25H28N6O/c1-17-6-8-22(31-12-10-19(3)29-31)21(13-17)25(32)30-11-4-5-18(2)23(30)16-28-24-9-7-20(14-26)15-27-24/h6-10,12-13,15,18,23H,4-5,11,16H2,1-3H3,(H,27,28)/t18-,23-/m1/s1	FRGAPXCPMZPRKS-WZONZLPQSA-N	373374	6-((((2S,3R)-3-Methyl-1-(5-methyl-2-(3-methyl-1H-pyrazol-1-yl)benzoyl)piperidin-2-yl)methyl)amino)nicotinonitrile::US9896452, Ex. A133	Orexin/Hypocretin receptor type 1	Homo sapiens		 93.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373374	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373374&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727687	404342468							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741230	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C#N)C(=O)c1cc(C)ccc1-n1ccc(C)n1	InChI=1S/C25H28N6O/c1-17-6-8-22(31-12-10-19(3)29-31)21(13-17)25(32)30-11-4-5-18(2)23(30)16-28-24-9-7-20(14-26)15-27-24/h6-10,12-13,15,18,23H,4-5,11,16H2,1-3H3,(H,27,28)/t18-,23-/m1/s1	FRGAPXCPMZPRKS-WZONZLPQSA-N	373374	6-((((2S,3R)-3-Methyl-1-(5-methyl-2-(3-methyl-1H-pyrazol-1-yl)benzoyl)piperidin-2-yl)methyl)amino)nicotinonitrile::US9896452, Ex. A133	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373374	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373374&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727687	404342468							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741231	C[C@@H]1CCCN([C@@H]1CNc1ncc(cn1)C#N)C(=O)c1cc(C)ccc1-n1nccn1	InChI=1S/C22H24N8O/c1-15-5-6-19(30-27-7-8-28-30)18(10-15)21(31)29-9-3-4-16(2)20(29)14-26-22-24-12-17(11-23)13-25-22/h5-8,10,12-13,16,20H,3-4,9,14H2,1-2H3,(H,24,25,26)/t16-,20-/m1/s1	JGUOBSQQYXZYNI-OXQOHEQNSA-N	373375	2-((((2S,3R)-3-Methyl-1-(5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl)piperidin-2-yl)methyl)amino)pyrimidine-5-carbonitrile::US9896452, Ex. A134	Orexin/Hypocretin receptor type 1	Homo sapiens		 150							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373375	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373375&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727856	404342469							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741232	C[C@@H]1CCCN([C@@H]1CNc1ncc(cn1)C#N)C(=O)c1cc(C)ccc1-n1nccn1	InChI=1S/C22H24N8O/c1-15-5-6-19(30-27-7-8-28-30)18(10-15)21(31)29-9-3-4-16(2)20(29)14-26-22-24-12-17(11-23)13-25-22/h5-8,10,12-13,16,20H,3-4,9,14H2,1-2H3,(H,24,25,26)/t16-,20-/m1/s1	JGUOBSQQYXZYNI-OXQOHEQNSA-N	373375	2-((((2S,3R)-3-Methyl-1-(5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl)piperidin-2-yl)methyl)amino)pyrimidine-5-carbonitrile::US9896452, Ex. A134	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373375	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373375&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727856	404342469							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741233	C[C@@H]1CCCN([C@@H]1CNc1nnc(s1)C(F)(F)F)C(=O)c1cc(C)ccc1-n1ncc(C)n1	InChI=1S/C21H24F3N7OS/c1-12-6-7-16(31-26-10-14(3)29-31)15(9-12)18(32)30-8-4-5-13(2)17(30)11-25-20-28-27-19(33-20)21(22,23)24/h6-7,9-10,13,17H,4-5,8,11H2,1-3H3,(H,25,28)/t13-,17-/m1/s1	VVGRATQGRFCDNT-CXAGYDPISA-N	373377	((2S,3R)-3-Methyl-2-(((5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(4-methyl-2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A135	Orexin/Hypocretin receptor type 1	Homo sapiens		 21.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373377	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373377&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727845	404342470							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741234	C[C@@H]1CCCN([C@@H]1CNc1nnc(s1)C(F)(F)F)C(=O)c1cc(C)ccc1-n1ncc(C)n1	InChI=1S/C21H24F3N7OS/c1-12-6-7-16(31-26-10-14(3)29-31)15(9-12)18(32)30-8-4-5-13(2)17(30)11-25-20-28-27-19(33-20)21(22,23)24/h6-7,9-10,13,17H,4-5,8,11H2,1-3H3,(H,25,28)/t13-,17-/m1/s1	VVGRATQGRFCDNT-CXAGYDPISA-N	373377	((2S,3R)-3-Methyl-2-(((5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(4-methyl-2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A135	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373377	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373377&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727845	404342470							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741235	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C1CC1)C(=O)c1cc(C)ccc1-n1nccn1	InChI=1S/C25H30N6O/c1-17-5-9-22(31-28-11-12-29-31)21(14-17)25(32)30-13-3-4-18(2)23(30)16-27-24-10-8-20(15-26-24)19-6-7-19/h5,8-12,14-15,18-19,23H,3-4,6-7,13,16H2,1-2H3,(H,26,27)/t18-,23-/m1/s1	ODRSUBOCIUQDQX-WZONZLPQSA-N	373378	((2S,3R)-2-(((5-Cyclopropylpyridin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A136	Orexin/Hypocretin receptor type 1	Homo sapiens		 4.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373378	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373378&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728315	404342471							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741236	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C1CC1)C(=O)c1cc(C)ccc1-n1nccn1	InChI=1S/C25H30N6O/c1-17-5-9-22(31-28-11-12-29-31)21(14-17)25(32)30-13-3-4-18(2)23(30)16-27-24-10-8-20(15-26-24)19-6-7-19/h5,8-12,14-15,18-19,23H,3-4,6-7,13,16H2,1-2H3,(H,26,27)/t18-,23-/m1/s1	ODRSUBOCIUQDQX-WZONZLPQSA-N	373378	((2S,3R)-2-(((5-Cyclopropylpyridin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A136	Orexin receptor type 2	Homo sapiens		 590							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373378	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373378&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117728315	404342471							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741237	C[C@@H]1CCCN([C@@H]1CNc1ccc(nn1)C(F)(F)F)C(=O)c1cc(C)ccc1-c1ncccn1	InChI=1S/C24H25F3N6O/c1-15-6-7-17(22-28-10-4-11-29-22)18(13-15)23(34)33-12-3-5-16(2)19(33)14-30-21-9-8-20(31-32-21)24(25,26)27/h4,6-11,13,16,19H,3,5,12,14H2,1-2H3,(H,30,32)/t16-,19-/m1/s1	HZRMCWBKAIBSGP-VQIMIIECSA-N	373379	((2S,3R)-3-Methyl-2-(((6-(trifluoromethyl)pyridazin-3-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(pyrimidin-2-yl)phenyl)methanone::US9896452, Ex. A137	Orexin/Hypocretin receptor type 1	Homo sapiens		 31.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373379	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373379&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728165	404342472							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741238	C[C@@H]1CCCN([C@@H]1CNc1ccc(nn1)C(F)(F)F)C(=O)c1cc(C)ccc1-c1ncccn1	InChI=1S/C24H25F3N6O/c1-15-6-7-17(22-28-10-4-11-29-22)18(13-15)23(34)33-12-3-5-16(2)19(33)14-30-21-9-8-20(31-32-21)24(25,26)27/h4,6-11,13,16,19H,3,5,12,14H2,1-2H3,(H,30,32)/t16-,19-/m1/s1	HZRMCWBKAIBSGP-VQIMIIECSA-N	373379	((2S,3R)-3-Methyl-2-(((6-(trifluoromethyl)pyridazin-3-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(pyrimidin-2-yl)phenyl)methanone::US9896452, Ex. A137	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373379	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373379&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117728165	404342472							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741239	C[C@@H]1CCCN([C@@H]1CNc1ccc(Cl)cn1)C(=O)c1cc(C)ccc1-c1ncccn1	InChI=1S/C24H26ClN5O/c1-16-6-8-19(23-26-10-4-11-27-23)20(13-16)24(31)30-12-3-5-17(2)21(30)15-29-22-9-7-18(25)14-28-22/h4,6-11,13-14,17,21H,3,5,12,15H2,1-2H3,(H,28,29)/t17-,21-/m1/s1	NDRJWFUYOQMTMX-DYESRHJHSA-N	373380	((2S,3R)-2-(((5-Chloropyridin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(pyrimidin-2-yl)phenyl)methanone::US9896452, Ex. A138	Orexin/Hypocretin receptor type 1	Homo sapiens		 12.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373380	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373380&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727998	404342473							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741240	C[C@@H]1CCCN([C@@H]1CNc1ccc(Cl)cn1)C(=O)c1cc(C)ccc1-c1ncccn1	InChI=1S/C24H26ClN5O/c1-16-6-8-19(23-26-10-4-11-27-23)20(13-16)24(31)30-12-3-5-17(2)21(30)15-29-22-9-7-18(25)14-28-22/h4,6-11,13-14,17,21H,3,5,12,15H2,1-2H3,(H,28,29)/t17-,21-/m1/s1	NDRJWFUYOQMTMX-DYESRHJHSA-N	373380	((2S,3R)-2-(((5-Chloropyridin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(pyrimidin-2-yl)phenyl)methanone::US9896452, Ex. A138	Orexin receptor type 2	Homo sapiens		 3400							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373380	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373380&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727998	404342473							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741241	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C#N)C(=O)c1cc(C)ccc1-c1ncccn1	InChI=1S/C25H26N6O/c1-17-6-8-20(24-27-10-4-11-28-24)21(13-17)25(32)31-12-3-5-18(2)22(31)16-30-23-9-7-19(14-26)15-29-23/h4,6-11,13,15,18,22H,3,5,12,16H2,1-2H3,(H,29,30)/t18-,22-/m1/s1	JYKPPEXOCDNDKA-XMSQKQJNSA-N	373381	6-((((2S,3R)-3-Methyl-1-(5-methyl-2-(pyrimidin-2-yl)benzoyl)piperidin-2-yl)methyl)amino)nicotinonitrile::US9896452, Ex. A139	Orexin/Hypocretin receptor type 1	Homo sapiens		 140							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373381	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373381&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728164	404342474							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741242	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C#N)C(=O)c1cc(C)ccc1-c1ncccn1	InChI=1S/C25H26N6O/c1-17-6-8-20(24-27-10-4-11-28-24)21(13-17)25(32)31-12-3-5-18(2)22(31)16-30-23-9-7-19(14-26)15-29-23/h4,6-11,13,15,18,22H,3,5,12,16H2,1-2H3,(H,29,30)/t18-,22-/m1/s1	JYKPPEXOCDNDKA-XMSQKQJNSA-N	373381	6-((((2S,3R)-3-Methyl-1-(5-methyl-2-(pyrimidin-2-yl)benzoyl)piperidin-2-yl)methyl)amino)nicotinonitrile::US9896452, Ex. A139	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373381	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373381&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117728164	404342474							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741243	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C1(CC1)C#N)C(=O)c1cc(C)ccc1-n1nccn1	InChI=1S/C26H29N7O/c1-18-5-7-22(33-30-11-12-31-33)21(14-18)25(34)32-13-3-4-19(2)23(32)16-29-24-8-6-20(15-28-24)26(17-27)9-10-26/h5-8,11-12,14-15,19,23H,3-4,9-10,13,16H2,1-2H3,(H,28,29)/t19-,23-/m1/s1	QUADUSPYBLUAKD-AUSIDOKSSA-N	373382	1-(6-((((2S,3R)-3-Methyl-1-(5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl)piperidin-2-yl)methyl)amino)pyridin-3-yl)cyclopropanecarbonitrile::US9896452, Ex. A140	Orexin/Hypocretin receptor type 1	Homo sapiens		 13.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373382	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373382&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728340	404342475							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741244	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C1(CC1)C#N)C(=O)c1cc(C)ccc1-n1nccn1	InChI=1S/C26H29N7O/c1-18-5-7-22(33-30-11-12-31-33)21(14-18)25(34)32-13-3-4-19(2)23(32)16-29-24-8-6-20(15-28-24)26(17-27)9-10-26/h5-8,11-12,14-15,19,23H,3-4,9-10,13,16H2,1-2H3,(H,28,29)/t19-,23-/m1/s1	QUADUSPYBLUAKD-AUSIDOKSSA-N	373382	1-(6-((((2S,3R)-3-Methyl-1-(5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl)piperidin-2-yl)methyl)amino)pyridin-3-yl)cyclopropanecarbonitrile::US9896452, Ex. A140	Orexin receptor type 2	Homo sapiens		 790							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373382	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373382&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117728340	404342475							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741245	C[C@@H]1CCCN([C@@H]1CNc1nc2cc(F)ccc2o1)C(=O)c1cc(C)ccc1-n1ncc(C)n1	InChI=1S/C25H27FN6O2/c1-15-6-8-21(32-28-13-17(3)30-32)19(11-15)24(33)31-10-4-5-16(2)22(31)14-27-25-29-20-12-18(26)7-9-23(20)34-25/h6-9,11-13,16,22H,4-5,10,14H2,1-3H3,(H,27,29)/t16-,22-/m1/s1	YCYUDFTUFUSQNS-OPAMFIHVSA-N	373383	((2S,3R)-2-(((5-Fluorobenzo[d]oxazol-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(4-methyl-2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A141	Orexin/Hypocretin receptor type 1	Homo sapiens		 3.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373383	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373383&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728313	404342476							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741246	C[C@@H]1CCCN([C@@H]1CNc1nc2cc(F)ccc2o1)C(=O)c1cc(C)ccc1-n1ncc(C)n1	InChI=1S/C25H27FN6O2/c1-15-6-8-21(32-28-13-17(3)30-32)19(11-15)24(33)31-10-4-5-16(2)22(31)14-27-25-29-20-12-18(26)7-9-23(20)34-25/h6-9,11-13,16,22H,4-5,10,14H2,1-3H3,(H,27,29)/t16-,22-/m1/s1	YCYUDFTUFUSQNS-OPAMFIHVSA-N	373383	((2S,3R)-2-(((5-Fluorobenzo[d]oxazol-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(4-methyl-2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A141	Orexin receptor type 2	Homo sapiens		 86.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373383	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373383&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117728313	404342476							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741247	C[C@@H]1CCCN([C@@H]1CNc1ccc(F)cn1)C(=O)c1cc(C)ccc1-n1ncc(C)n1	InChI=1S/C23H27FN6O/c1-15-6-8-20(30-27-12-17(3)28-30)19(11-15)23(31)29-10-4-5-16(2)21(29)14-26-22-9-7-18(24)13-25-22/h6-9,11-13,16,21H,4-5,10,14H2,1-3H3,(H,25,26)/t16-,21-/m1/s1	XTCVCLFBQLKQPA-IIBYNOLFSA-N	373384	((2S,3R)-2-(((5-Fluoropyridin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(4-methyl-2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A142	Orexin/Hypocretin receptor type 1	Homo sapiens		 51.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373384	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373384&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728183	404342477							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741248	C[C@@H]1CCCN([C@@H]1CNc1ccc(F)cn1)C(=O)c1cc(C)ccc1-n1ncc(C)n1	InChI=1S/C23H27FN6O/c1-15-6-8-20(30-27-12-17(3)28-30)19(11-15)23(31)29-10-4-5-16(2)21(29)14-26-22-9-7-18(24)13-25-22/h6-9,11-13,16,21H,4-5,10,14H2,1-3H3,(H,25,26)/t16-,21-/m1/s1	XTCVCLFBQLKQPA-IIBYNOLFSA-N	373384	((2S,3R)-2-(((5-Fluoropyridin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(4-methyl-2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A142	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373384	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373384&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117728183	404342477							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741249	C[C@@H]1CCCN([C@@H]1CNc1ccc(C)cn1)C(=O)c1cc(C)ccc1-c1ncccn1	InChI=1S/C25H29N5O/c1-17-7-9-20(24-26-11-5-12-27-24)21(14-17)25(31)30-13-4-6-19(3)22(30)16-29-23-10-8-18(2)15-28-23/h5,7-12,14-15,19,22H,4,6,13,16H2,1-3H3,(H,28,29)/t19-,22-/m1/s1	PXAVUEYDDTVGEN-DENIHFKCSA-N	373385	((2S,3R)-3-Methyl-2-(((5-methylpyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(pyrimidin-2-yl)phenyl)methanone::US9896452, Ex. A143	Orexin/Hypocretin receptor type 1	Homo sapiens		 26.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373385	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373385&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727803	404342478							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741250	C[C@@H]1CCCN([C@@H]1CNc1ccc(C)cn1)C(=O)c1cc(C)ccc1-c1ncccn1	InChI=1S/C25H29N5O/c1-17-7-9-20(24-26-11-5-12-27-24)21(14-17)25(31)30-13-4-6-19(3)22(30)16-29-23-10-8-18(2)15-28-23/h5,7-12,14-15,19,22H,4,6,13,16H2,1-3H3,(H,28,29)/t19-,22-/m1/s1	PXAVUEYDDTVGEN-DENIHFKCSA-N	373385	((2S,3R)-3-Methyl-2-(((5-methylpyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(pyrimidin-2-yl)phenyl)methanone::US9896452, Ex. A143	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373385	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373385&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727803	404342478							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741251	C[C@@H]1CCCN([C@@H]1CNc1ccc(nn1)C#N)C(=O)c1cc(C)ccc1-n1nccn1	InChI=1S/C22H24N8O/c1-15-5-7-19(30-25-9-10-26-30)18(12-15)22(31)29-11-3-4-16(2)20(29)14-24-21-8-6-17(13-23)27-28-21/h5-10,12,16,20H,3-4,11,14H2,1-2H3,(H,24,28)/t16-,20-/m1/s1	DSNITHVCCIMLAP-OXQOHEQNSA-N	373386	6-((((2S,3R)-3-Methyl-1-(5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl)piperidin-2-yl)methyl)amino)pyridazine-3-carbonitrile::US9896452, Ex. A145	Orexin/Hypocretin receptor type 1	Homo sapiens		>1000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373386	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373386&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727851	404342479							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741252	C[C@@H]1CCCN([C@@H]1CNc1ccc(C)nn1)C(=O)c1cc(C)ccc1-n1nccn1	InChI=1S/C22H27N7O/c1-15-6-8-19(29-24-10-11-25-29)18(13-15)22(30)28-12-4-5-16(2)20(28)14-23-21-9-7-17(3)26-27-21/h6-11,13,16,20H,4-5,12,14H2,1-3H3,(H,23,27)/t16-,20-/m1/s1	LJRXMPRKWNIMRG-OXQOHEQNSA-N	373388	((2S,3R)-3-Methyl-2-(((6-methylpyridazin-3-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A146	Orexin/Hypocretin receptor type 1	Homo sapiens		>1000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373388	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373388&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727729	404342480							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741253	C[C@@H]1CCCN([C@@H]1CNc1ncc(Cl)cn1)C(=O)c1cc(C)ccc1-n1nccn1	InChI=1S/C21H24ClN7O/c1-14-5-6-18(29-26-7-8-27-29)17(10-14)20(30)28-9-3-4-15(2)19(28)13-25-21-23-11-16(22)12-24-21/h5-8,10-12,15,19H,3-4,9,13H2,1-2H3,(H,23,24,25)/t15-,19-/m1/s1	NGSXSHQBMOQXPL-DNVCBOLYSA-N	373235	US9896452, Ex. A147::US9896452, Example 98::rac-((2S,3R)-2-(((5-chloropyrimidin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone	Orexin/Hypocretin receptor type 1	Homo sapiens		 8.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373235	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373235&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89748215	404342337							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741254	C[C@@H]1CCCN([C@@H]1CNc1ncc(Cl)cn1)C(=O)c1cc(C)ccc1-n1nccn1	InChI=1S/C21H24ClN7O/c1-14-5-6-18(29-26-7-8-27-29)17(10-14)20(30)28-9-3-4-15(2)19(28)13-25-21-23-11-16(22)12-24-21/h5-8,10-12,15,19H,3-4,9,13H2,1-2H3,(H,23,24,25)/t15-,19-/m1/s1	NGSXSHQBMOQXPL-DNVCBOLYSA-N	373235	US9896452, Ex. A147::US9896452, Example 98::rac-((2S,3R)-2-(((5-chloropyrimidin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373235	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373235&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			89748215	404342337							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741255	C[C@@H]1CCCN([C@@H]1CNc1ncc(cc1F)C#N)C(=O)c1cc(C)ccc1-n1nccn1	InChI=1S/C23H24FN7O/c1-15-5-6-20(31-28-7-8-29-31)18(10-15)23(32)30-9-3-4-16(2)21(30)14-27-22-19(24)11-17(12-25)13-26-22/h5-8,10-11,13,16,21H,3-4,9,14H2,1-2H3,(H,26,27)/t16-,21-/m1/s1	HMWCLKDXLYUSTH-IIBYNOLFSA-N	373390	5-Fluoro-6-((((2S,3R)-3-methyl-1-(5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl)piperidin-2-yl)methyl)amino)nicotinonitrile::US9896452, Ex. A148	Orexin/Hypocretin receptor type 1	Homo sapiens		 83.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373390	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373390&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727865	404342481							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741256	C[C@@H]1CCCN([C@@H]1CNc1ncc(cc1F)C#N)C(=O)c1cc(C)ccc1-n1nccn1	InChI=1S/C23H24FN7O/c1-15-5-6-20(31-28-7-8-29-31)18(10-15)23(32)30-9-3-4-16(2)21(30)14-27-22-19(24)11-17(12-25)13-26-22/h5-8,10-11,13,16,21H,3-4,9,14H2,1-2H3,(H,26,27)/t16-,21-/m1/s1	HMWCLKDXLYUSTH-IIBYNOLFSA-N	373390	5-Fluoro-6-((((2S,3R)-3-methyl-1-(5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl)piperidin-2-yl)methyl)amino)nicotinonitrile::US9896452, Ex. A148	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373390	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373390&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727865	404342481							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741257	C[C@@H]1CCCN([C@@H]1CNc1ncc(cn1)C(F)(F)F)C(=O)c1cc(C)ccc1-n1nccn1	InChI=1S/C22H24F3N7O/c1-14-5-6-18(32-29-7-8-30-32)17(10-14)20(33)31-9-3-4-15(2)19(31)13-28-21-26-11-16(12-27-21)22(23,24)25/h5-8,10-12,15,19H,3-4,9,13H2,1-2H3,(H,26,27,28)/t15-,19-/m1/s1	UOFUCJWLSMCUJD-DNVCBOLYSA-N	373234	US9896452, Ex. A149::US9896452, Example 97::rac-((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone	Orexin/Hypocretin receptor type 1	Homo sapiens		 3.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373234	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373234&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			89748240	404342336							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741258	C[C@@H]1CCCN([C@@H]1CNc1ncc(cn1)C(F)(F)F)C(=O)c1cc(C)ccc1-n1nccn1	InChI=1S/C22H24F3N7O/c1-14-5-6-18(32-29-7-8-30-32)17(10-14)20(33)31-9-3-4-15(2)19(31)13-28-21-26-11-16(12-27-21)22(23,24)25/h5-8,10-12,15,19H,3-4,9,13H2,1-2H3,(H,26,27,28)/t15-,19-/m1/s1	UOFUCJWLSMCUJD-DNVCBOLYSA-N	373234	US9896452, Ex. A149::US9896452, Example 97::rac-((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373234	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373234&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			89748240	404342336							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741259	C[C@@H]1CCCN([C@@H]1CNc1ccc(nn1)C(F)(F)F)C(=O)c1cc(C)ccc1-c1ccccn1	InChI=1S/C25H26F3N5O/c1-16-8-9-18(20-7-3-4-12-29-20)19(14-16)24(34)33-13-5-6-17(2)21(33)15-30-23-11-10-22(31-32-23)25(26,27)28/h3-4,7-12,14,17,21H,5-6,13,15H2,1-2H3,(H,30,32)/t17-,21-/m1/s1	SRCLRKQPKBHJOT-DYESRHJHSA-N	373392	((2S,3R)-3-Methyl-2-(((6-(trifluoromethyl)pyridazin-3-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(pyridin-2-yl)phenyl)methanone::US9896452, Ex. A150	Orexin/Hypocretin receptor type 1	Homo sapiens		 130							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373392	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373392&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117729258	404342482							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741260	C[C@@H]1CCCN([C@@H]1CNc1ccc(nn1)C(F)(F)F)C(=O)c1cc(C)ccc1-c1ccccn1	InChI=1S/C25H26F3N5O/c1-16-8-9-18(20-7-3-4-12-29-20)19(14-16)24(34)33-13-5-6-17(2)21(33)15-30-23-11-10-22(31-32-23)25(26,27)28/h3-4,7-12,14,17,21H,5-6,13,15H2,1-2H3,(H,30,32)/t17-,21-/m1/s1	SRCLRKQPKBHJOT-DYESRHJHSA-N	373392	((2S,3R)-3-Methyl-2-(((6-(trifluoromethyl)pyridazin-3-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(pyridin-2-yl)phenyl)methanone::US9896452, Ex. A150	Orexin receptor type 2	Homo sapiens		 4000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373392	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373392&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117729258	404342482							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741261	C[C@@H]1CCCN([C@@H]1CNc1nnc(s1)C(F)(F)F)C(=O)c1cc(C)ccc1-c1ccccn1	InChI=1S/C23H24F3N5OS/c1-14-8-9-16(18-7-3-4-10-27-18)17(12-14)20(32)31-11-5-6-15(2)19(31)13-28-22-30-29-21(33-22)23(24,25)26/h3-4,7-10,12,15,19H,5-6,11,13H2,1-2H3,(H,28,30)/t15-,19-/m1/s1	MBXXWRKSWWCYFA-DNVCBOLYSA-N	373393	((2S,3R)-3-Methyl-2-(((5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(pyridin-2-yl)phenyl)methanone::US9896452, Ex. A151	Orexin/Hypocretin receptor type 1	Homo sapiens		 83.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373393	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373393&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728032	404342483							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741262	C[C@@H]1CCCN([C@@H]1CNc1nnc(s1)C(F)(F)F)C(=O)c1cc(C)ccc1-c1ccccn1	InChI=1S/C23H24F3N5OS/c1-14-8-9-16(18-7-3-4-10-27-18)17(12-14)20(32)31-11-5-6-15(2)19(31)13-28-22-30-29-21(33-22)23(24,25)26/h3-4,7-10,12,15,19H,5-6,11,13H2,1-2H3,(H,28,30)/t15-,19-/m1/s1	MBXXWRKSWWCYFA-DNVCBOLYSA-N	373393	((2S,3R)-3-Methyl-2-(((5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(pyridin-2-yl)phenyl)methanone::US9896452, Ex. A151	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373393	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373393&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117728032	404342483							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741263	C[C@@H]1CCCN([C@@H]1CNc1ncc(cn1)C(F)(F)F)C(=O)c1cc(C)ccc1-c1ccccn1	InChI=1S/C25H26F3N5O/c1-16-8-9-19(21-7-3-4-10-29-21)20(12-16)23(34)33-11-5-6-17(2)22(33)15-32-24-30-13-18(14-31-24)25(26,27)28/h3-4,7-10,12-14,17,22H,5-6,11,15H2,1-2H3,(H,30,31,32)/t17-,22-/m1/s1	SADIGGDWYUDOPY-VGOFRKELSA-N	373394	((2S,3R)-3-Methyl-2-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(pyridin-2-yl)phenyl)methanone::US9896452, Ex. A152	Orexin/Hypocretin receptor type 1	Homo sapiens		 4.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373394	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373394&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728853	404342484							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741264	C[C@@H]1CCCN([C@@H]1CNc1ncc(cn1)C(F)(F)F)C(=O)c1cc(C)ccc1-c1ccccn1	InChI=1S/C25H26F3N5O/c1-16-8-9-19(21-7-3-4-10-29-21)20(12-16)23(34)33-11-5-6-17(2)22(33)15-32-24-30-13-18(14-31-24)25(26,27)28/h3-4,7-10,12-14,17,22H,5-6,11,15H2,1-2H3,(H,30,31,32)/t17-,22-/m1/s1	SADIGGDWYUDOPY-VGOFRKELSA-N	373394	((2S,3R)-3-Methyl-2-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(pyridin-2-yl)phenyl)methanone::US9896452, Ex. A152	Orexin receptor type 2	Homo sapiens		 2000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373394	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373394&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117728853	404342484							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741265	C[C@@H]1CCCN([C@@H]1CNc1ncc(cn1)C#N)C(=O)c1cc(C)ccc1-c1ccccn1	InChI=1S/C25H26N6O/c1-17-8-9-20(22-7-3-4-10-27-22)21(12-17)24(32)31-11-5-6-18(2)23(31)16-30-25-28-14-19(13-26)15-29-25/h3-4,7-10,12,14-15,18,23H,5-6,11,16H2,1-2H3,(H,28,29,30)/t18-,23-/m1/s1	DIOAJPZXKSVEOF-WZONZLPQSA-N	373395	2-((((2S,3R)-3-Methyl-1-(5-methyl-2-(pyridin-2-yl)benzoyl)piperidin-2-yl)methyl)amino)pyrimidine-5-carbonitrile::US9896452, Ex. A153	Orexin/Hypocretin receptor type 1	Homo sapiens		 140							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373395	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373395&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728167	404342485							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741266	C[C@@H]1CCCN([C@@H]1CNc1ncc(cn1)C#N)C(=O)c1cc(C)ccc1-c1ccccn1	InChI=1S/C25H26N6O/c1-17-8-9-20(22-7-3-4-10-27-22)21(12-17)24(32)31-11-5-6-18(2)23(31)16-30-25-28-14-19(13-26)15-29-25/h3-4,7-10,12,14-15,18,23H,5-6,11,16H2,1-2H3,(H,28,29,30)/t18-,23-/m1/s1	DIOAJPZXKSVEOF-WZONZLPQSA-N	373395	2-((((2S,3R)-3-Methyl-1-(5-methyl-2-(pyridin-2-yl)benzoyl)piperidin-2-yl)methyl)amino)pyrimidine-5-carbonitrile::US9896452, Ex. A153	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373395	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373395&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117728167	404342485							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741267	C[C@@H]1CCCN([C@@H]1CNc1ccc(C)nn1)C(=O)c1cc(C)ccc1-n1cccn1	InChI=1S/C23H28N6O/c1-16-7-9-20(29-13-5-11-25-29)19(14-16)23(30)28-12-4-6-17(2)21(28)15-24-22-10-8-18(3)26-27-22/h5,7-11,13-14,17,21H,4,6,12,15H2,1-3H3,(H,24,27)/t17-,21-/m1/s1	JVXZUIATRCAXSB-DYESRHJHSA-N	373396	((2S,3R)-3-Methyl-2-(((6-methylpyridazin-3-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(1H-pyrazol-1-yl)phenyl)methanone::US9896452, Ex. A154	Orexin/Hypocretin receptor type 1	Homo sapiens		>1000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373396	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373396&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727657	404342486							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741268	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C#N)C(=O)c1cc(C)ccc1-n1cccn1	InChI=1S/C24H26N6O/c1-17-6-8-21(30-12-4-10-28-30)20(13-17)24(31)29-11-3-5-18(2)22(29)16-27-23-9-7-19(14-25)15-26-23/h4,6-10,12-13,15,18,22H,3,5,11,16H2,1-2H3,(H,26,27)/t18-,22-/m1/s1	RMDXIELGJALRDL-XMSQKQJNSA-N	373397	6-((((2S,3R)-3-Methyl-1-(5-methyl-2-(1H-pyrazol-1-yl)benzoyl)piperidin-2-yl)methyl)amino)nicotinonitrile::US9896452, Ex. A155	Orexin/Hypocretin receptor type 1	Homo sapiens		 500							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373397	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373397&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727904	404342487							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741269	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C#N)C(=O)c1cc(C)ccc1-n1cccn1	InChI=1S/C24H26N6O/c1-17-6-8-21(30-12-4-10-28-30)20(13-17)24(31)29-11-3-5-18(2)22(29)16-27-23-9-7-19(14-25)15-26-23/h4,6-10,12-13,15,18,22H,3,5,11,16H2,1-2H3,(H,26,27)/t18-,22-/m1/s1	RMDXIELGJALRDL-XMSQKQJNSA-N	373397	6-((((2S,3R)-3-Methyl-1-(5-methyl-2-(1H-pyrazol-1-yl)benzoyl)piperidin-2-yl)methyl)amino)nicotinonitrile::US9896452, Ex. A155	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373397	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373397&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727904	404342487							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741270	C[C@@H]1CCCN([C@@H]1CNc1ccc(nn1)C#N)C(=O)c1cc(C)ccc1-n1cccn1	InChI=1S/C23H25N7O/c1-16-6-8-20(30-12-4-10-26-30)19(13-16)23(31)29-11-3-5-17(2)21(29)15-25-22-9-7-18(14-24)27-28-22/h4,6-10,12-13,17,21H,3,5,11,15H2,1-2H3,(H,25,28)/t17-,21-/m1/s1	ILLMJEHGNCPHFO-DYESRHJHSA-N	373398	6-((((2S,3R)-3-Methyl-1-(5-methyl-2-(1H-pyrazol-1-yl)benzoyl)piperidin-2-yl)methyl)amino)pyridazine-3-carbonitrile::US9896452, Ex. A156	Orexin/Hypocretin receptor type 1	Homo sapiens		>1000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373398	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373398&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727767	404342488							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741271	C[C@@H]1CCCN([C@@H]1CNc1ccc(nn1)C(F)(F)F)C(=O)c1cc(C)ccc1-n1cccn1	InChI=1S/C23H25F3N6O/c1-15-6-7-18(32-12-4-10-28-32)17(13-15)22(33)31-11-3-5-16(2)19(31)14-27-21-9-8-20(29-30-21)23(24,25)26/h4,6-10,12-13,16,19H,3,5,11,14H2,1-2H3,(H,27,30)/t16-,19-/m1/s1	BUFJQKGAQYUTDE-VQIMIIECSA-N	373399	((2S,3R)-3-mMethyl-2-(((6-(trifluoromethyl)pyridazin-3-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(1H-pyrazol-1-yl)phenyl)methanone::US9896452, Ex. A157	Orexin/Hypocretin receptor type 1	Homo sapiens		 110							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373399	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373399&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728769	404342489							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741272	C[C@@H]1CCCN([C@@H]1CNc1ccc(nn1)C(F)(F)F)C(=O)c1cc(C)ccc1-n1cccn1	InChI=1S/C23H25F3N6O/c1-15-6-7-18(32-12-4-10-28-32)17(13-15)22(33)31-11-3-5-16(2)19(31)14-27-21-9-8-20(29-30-21)23(24,25)26/h4,6-10,12-13,16,19H,3,5,11,14H2,1-2H3,(H,27,30)/t16-,19-/m1/s1	BUFJQKGAQYUTDE-VQIMIIECSA-N	373399	((2S,3R)-3-mMethyl-2-(((6-(trifluoromethyl)pyridazin-3-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(1H-pyrazol-1-yl)phenyl)methanone::US9896452, Ex. A157	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373399	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373399&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117728769	404342489							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741273	C[C@@H]1CCCN([C@@H]1CNc1ccc(Cl)cn1)C(=O)c1cc(C)ccc1-c1ccc(cn1)C(F)(F)F	InChI=1S/C26H26ClF3N4O/c1-16-5-8-20(22-9-6-18(13-31-22)26(28,29)30)21(12-16)25(35)34-11-3-4-17(2)23(34)15-33-24-10-7-19(27)14-32-24/h5-10,12-14,17,23H,3-4,11,15H2,1-2H3,(H,32,33)/t17-,23-/m1/s1	FPVULEDUFZGDIV-UZUQRXQVSA-N	373400	((2S,3R)-2-(((5-Chloropyridin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(5-(trifluoromethyl)pyridin-2-yl)phenyl)methanone::US9896452, Ex. A158	Orexin/Hypocretin receptor type 1	Homo sapiens		 220							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373400	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373400&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728016	404342490							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741274	C[C@@H]1CCCN([C@@H]1CNc1ccc(Cl)cn1)C(=O)c1cc(C)ccc1-c1ccc(cn1)C(F)(F)F	InChI=1S/C26H26ClF3N4O/c1-16-5-8-20(22-9-6-18(13-31-22)26(28,29)30)21(12-16)25(35)34-11-3-4-17(2)23(34)15-33-24-10-7-19(27)14-32-24/h5-10,12-14,17,23H,3-4,11,15H2,1-2H3,(H,32,33)/t17-,23-/m1/s1	FPVULEDUFZGDIV-UZUQRXQVSA-N	373400	((2S,3R)-2-(((5-Chloropyridin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(5-(trifluoromethyl)pyridin-2-yl)phenyl)methanone::US9896452, Ex. A158	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373400	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373400&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117728016	404342490							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741275	C[C@@H]1CCCN([C@@H]1CNc1ccc(Cl)cn1)C(=O)c1cc(C)ccc1-c1ccc(F)cn1	InChI=1S/C25H26ClFN4O/c1-16-5-8-20(22-9-7-19(27)14-28-22)21(12-16)25(32)31-11-3-4-17(2)23(31)15-30-24-10-6-18(26)13-29-24/h5-10,12-14,17,23H,3-4,11,15H2,1-2H3,(H,29,30)/t17-,23-/m1/s1	QHSRSTPPAWBUHN-UZUQRXQVSA-N	373401	((2S,3R)-2-(((5-Chloropyridin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(2-(5-fluoropyridin-2-yl)-5-methylphenyl)methanone::US9896452, Ex. A159	Orexin/Hypocretin receptor type 1	Homo sapiens		 170							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373401	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373401&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727898	404342491							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741276	C[C@@H]1CCCN([C@@H]1CNc1ccc(Cl)cn1)C(=O)c1cc(C)ccc1-c1ccc(F)cn1	InChI=1S/C25H26ClFN4O/c1-16-5-8-20(22-9-7-19(27)14-28-22)21(12-16)25(32)31-11-3-4-17(2)23(31)15-30-24-10-6-18(26)13-29-24/h5-10,12-14,17,23H,3-4,11,15H2,1-2H3,(H,29,30)/t17-,23-/m1/s1	QHSRSTPPAWBUHN-UZUQRXQVSA-N	373401	((2S,3R)-2-(((5-Chloropyridin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(2-(5-fluoropyridin-2-yl)-5-methylphenyl)methanone::US9896452, Ex. A159	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373401	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373401&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727898	404342491							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741277	C[C@@H]1CCCN([C@@H]1CNc1ncc(cn1)C(F)(F)F)C(=O)c1cc(Cl)ccc1-n1nccn1	InChI=1S/C21H21ClF3N7O/c1-13-3-2-8-31(18(13)12-28-20-26-10-14(11-27-20)21(23,24)25)19(33)16-9-15(22)4-5-17(16)32-29-6-7-30-32/h4-7,9-11,13,18H,2-3,8,12H2,1H3,(H,26,27,28)/t13-,18-/m1/s1	BKTDEMAGNQFCMV-FZKQIMNGSA-N	373402	(5-Chloro-2-(2H-1,2,3-triazol-2-yl)phenyl)((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidin-1-yl)methanone::US9896452, Ex. A160	Orexin/Hypocretin receptor type 1	Homo sapiens		 1.000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373402	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373402&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727673	404342492							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741278	C[C@@H]1CCCN([C@@H]1CNc1ncc(cn1)C(F)(F)F)C(=O)c1cc(Cl)ccc1-n1nccn1	InChI=1S/C21H21ClF3N7O/c1-13-3-2-8-31(18(13)12-28-20-26-10-14(11-27-20)21(23,24)25)19(33)16-9-15(22)4-5-17(16)32-29-6-7-30-32/h4-7,9-11,13,18H,2-3,8,12H2,1H3,(H,26,27,28)/t13-,18-/m1/s1	BKTDEMAGNQFCMV-FZKQIMNGSA-N	373402	(5-Chloro-2-(2H-1,2,3-triazol-2-yl)phenyl)((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidin-1-yl)methanone::US9896452, Ex. A160	Orexin receptor type 2	Homo sapiens		 1300							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373402	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373402&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727673	404342492							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741279	C[C@@H]1CCCN([C@@H]1CNc1ccc(Cl)cn1)C(=O)c1cc(Cl)ccc1-n1nccn1	InChI=1S/C21H22Cl2N6O/c1-14-3-2-10-28(19(14)13-25-20-7-5-16(23)12-24-20)21(30)17-11-15(22)4-6-18(17)29-26-8-9-27-29/h4-9,11-12,14,19H,2-3,10,13H2,1H3,(H,24,25)/t14-,19-/m1/s1	YLEGFLMTDIRMPY-AUUYWEPGSA-N	373403	(5-Chloro-2-(2H-1,2,3-triazol-2-yl)phenyl)((2S,3R)-2-(((5-chloropyridin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)methanone::US9896452, Ex. A161	Orexin/Hypocretin receptor type 1	Homo sapiens		 13.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373403	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373403&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117729093	404342493							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741280	C[C@@H]1CCCN([C@@H]1CNc1ccc(Cl)cn1)C(=O)c1cc(Cl)ccc1-n1nccn1	InChI=1S/C21H22Cl2N6O/c1-14-3-2-10-28(19(14)13-25-20-7-5-16(23)12-24-20)21(30)17-11-15(22)4-6-18(17)29-26-8-9-27-29/h4-9,11-12,14,19H,2-3,10,13H2,1H3,(H,24,25)/t14-,19-/m1/s1	YLEGFLMTDIRMPY-AUUYWEPGSA-N	373403	(5-Chloro-2-(2H-1,2,3-triazol-2-yl)phenyl)((2S,3R)-2-(((5-chloropyridin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)methanone::US9896452, Ex. A161	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373403	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373403&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117729093	404342493							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741281	C[C@@H]1CCCN([C@@H]1CNc1ccc(nn1)C(F)(F)F)C(=O)c1cc(Cl)ccc1-n1nccn1	InChI=1S/C21H21ClF3N7O/c1-13-3-2-10-31(17(13)12-26-19-7-6-18(29-30-19)21(23,24)25)20(33)15-11-14(22)4-5-16(15)32-27-8-9-28-32/h4-9,11,13,17H,2-3,10,12H2,1H3,(H,26,30)/t13-,17-/m1/s1	DOMZNEDFRRLOTC-CXAGYDPISA-N	373404	(5-Chloro-2-(2H-1,2,3-triazol-2-yl)phenyl)((2S,3R)-3-methyl-2-(((6-(trifluoromethyl)pyridazin-3-yl)amino)methyl)piperidin-1-yl)methanone::US9896452, Ex. A162	Orexin/Hypocretin receptor type 1	Homo sapiens		 15.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373404	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373404&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727960	404342494							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741282	C[C@@H]1CCCN([C@@H]1CNc1ccc(nn1)C(F)(F)F)C(=O)c1cc(Cl)ccc1-n1nccn1	InChI=1S/C21H21ClF3N7O/c1-13-3-2-10-31(17(13)12-26-19-7-6-18(29-30-19)21(23,24)25)20(33)15-11-14(22)4-5-16(15)32-27-8-9-28-32/h4-9,11,13,17H,2-3,10,12H2,1H3,(H,26,30)/t13-,17-/m1/s1	DOMZNEDFRRLOTC-CXAGYDPISA-N	373404	(5-Chloro-2-(2H-1,2,3-triazol-2-yl)phenyl)((2S,3R)-3-methyl-2-(((6-(trifluoromethyl)pyridazin-3-yl)amino)methyl)piperidin-1-yl)methanone::US9896452, Ex. A162	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373404	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373404&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727960	404342494							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741283	C[C@@H]1CCCN([C@@H]1CNc1nccc(n1)C(F)(F)F)C(=O)c1cc(C)ccc1-n1nccn1	InChI=1S/C22H24F3N7O/c1-14-5-6-17(32-28-9-10-29-32)16(12-14)20(33)31-11-3-4-15(2)18(31)13-27-21-26-8-7-19(30-21)22(23,24)25/h5-10,12,15,18H,3-4,11,13H2,1-2H3,(H,26,27,30)/t15-,18-/m1/s1	GLSUOGDEYDDDIC-CRAIPNDOSA-N	373405	((2S,3R)-3-Methyl-2-(((4-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A163	Orexin/Hypocretin receptor type 1	Homo sapiens		 71.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373405	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373405&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727738	404342495							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741284	C[C@@H]1CCCN([C@@H]1CNc1nccc(n1)C(F)(F)F)C(=O)c1cc(C)ccc1-n1nccn1	InChI=1S/C22H24F3N7O/c1-14-5-6-17(32-28-9-10-29-32)16(12-14)20(33)31-11-3-4-15(2)18(31)13-27-21-26-8-7-19(30-21)22(23,24)25/h5-10,12,15,18H,3-4,11,13H2,1-2H3,(H,26,27,30)/t15-,18-/m1/s1	GLSUOGDEYDDDIC-CRAIPNDOSA-N	373405	((2S,3R)-3-Methyl-2-(((4-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A163	Orexin receptor type 2	Homo sapiens		 1200							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373405	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373405&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727738	404342495							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741285	C[C@@H]1CCCN([C@@H]1CNc1ccc(nn1)C(F)(F)F)C(=O)c1nc(C)ccc1-n1cccn1	InChI=1S/C22H24F3N7O/c1-14-5-3-11-31(17(14)13-26-19-9-8-18(29-30-19)22(23,24)25)21(33)20-16(7-6-15(2)28-20)32-12-4-10-27-32/h4,6-10,12,14,17H,3,5,11,13H2,1-2H3,(H,26,30)/t14-,17-/m1/s1	LAXVDPFCORHHCM-RHSMWYFYSA-N	373406	((2S,3R)-3-Methyl-2-(((6-(trifluoromethyl)pyridazin-3-yl)amino)methyl)piperidin-1-yl)(6-methyl-3-(1H-pyrazol-1-yl)pyridin-2-yl)methanone::US9896452, Ex. A164	Orexin/Hypocretin receptor type 1	Homo sapiens		 75.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373406	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373406&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727911	404342496							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741286	C[C@@H]1CCCN([C@@H]1CNc1ccc(nn1)C(F)(F)F)C(=O)c1nc(C)ccc1-n1cccn1	InChI=1S/C22H24F3N7O/c1-14-5-3-11-31(17(14)13-26-19-9-8-18(29-30-19)22(23,24)25)21(33)20-16(7-6-15(2)28-20)32-12-4-10-27-32/h4,6-10,12,14,17H,3,5,11,13H2,1-2H3,(H,26,30)/t14-,17-/m1/s1	LAXVDPFCORHHCM-RHSMWYFYSA-N	373406	((2S,3R)-3-Methyl-2-(((6-(trifluoromethyl)pyridazin-3-yl)amino)methyl)piperidin-1-yl)(6-methyl-3-(1H-pyrazol-1-yl)pyridin-2-yl)methanone::US9896452, Ex. A164	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373406	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373406&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727911	404342496							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741287	C[C@@H]1CCCN([C@@H]1CNc1ccc(nn1)C(F)(F)F)C(=O)c1nc(C)ccc1-c1ccccn1	InChI=1S/C24H25F3N6O/c1-15-6-5-13-33(19(15)14-29-21-11-10-20(31-32-21)24(25,26)27)23(34)22-17(9-8-16(2)30-22)18-7-3-4-12-28-18/h3-4,7-12,15,19H,5-6,13-14H2,1-2H3,(H,29,32)/t15-,19-/m1/s1	XFEKODPLXBOLIO-DNVCBOLYSA-N	373407	((2S,3R)-3-methyl-2-(((6-(trifluoromethyl)pyridazin-3-yl)amino)methyl)piperidin-1-yl)(6&#8242;-methyl-[2,3&#8242;-bipyridin]-2&#8242;-yl)methanone::US9896452, Ex. A165	Orexin/Hypocretin receptor type 1	Homo sapiens		 27.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373407	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373407&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728131	404342497							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741288	C[C@@H]1CCCN([C@@H]1CNc1ccc(nn1)C(F)(F)F)C(=O)c1nc(C)ccc1-c1ccccn1	InChI=1S/C24H25F3N6O/c1-15-6-5-13-33(19(15)14-29-21-11-10-20(31-32-21)24(25,26)27)23(34)22-17(9-8-16(2)30-22)18-7-3-4-12-28-18/h3-4,7-12,15,19H,5-6,13-14H2,1-2H3,(H,29,32)/t15-,19-/m1/s1	XFEKODPLXBOLIO-DNVCBOLYSA-N	373407	((2S,3R)-3-methyl-2-(((6-(trifluoromethyl)pyridazin-3-yl)amino)methyl)piperidin-1-yl)(6&#8242;-methyl-[2,3&#8242;-bipyridin]-2&#8242;-yl)methanone::US9896452, Ex. A165	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373407	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373407&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117728131	404342497							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741289	C[C@@H]1CCCN([C@@H]1CNc1ncc(cn1)C(F)(F)F)C(=O)c1nc(C)ccc1-n1cccn1	InChI=1S/C22H24F3N7O/c1-14-5-3-9-31(18(14)13-28-21-26-11-16(12-27-21)22(23,24)25)20(33)19-17(7-6-15(2)30-19)32-10-4-8-29-32/h4,6-8,10-12,14,18H,3,5,9,13H2,1-2H3,(H,26,27,28)/t14-,18-/m1/s1	ZYOMABPRPDBZDJ-RDTXWAMCSA-N	373408	((2S,3R)-3-Methyl-2-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidin-1-yl)(6-methyl-3-(1H-pyrazol-1-yl)pyridin-2-yl)methanone::US9896452, Ex. A166	Orexin/Hypocretin receptor type 1	Homo sapiens		 8.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373408	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373408&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728102	404342498							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741290	C[C@@H]1CCCN([C@@H]1CNc1ncc(cn1)C(F)(F)F)C(=O)c1nc(C)ccc1-n1cccn1	InChI=1S/C22H24F3N7O/c1-14-5-3-9-31(18(14)13-28-21-26-11-16(12-27-21)22(23,24)25)20(33)19-17(7-6-15(2)30-19)32-10-4-8-29-32/h4,6-8,10-12,14,18H,3,5,9,13H2,1-2H3,(H,26,27,28)/t14-,18-/m1/s1	ZYOMABPRPDBZDJ-RDTXWAMCSA-N	373408	((2S,3R)-3-Methyl-2-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidin-1-yl)(6-methyl-3-(1H-pyrazol-1-yl)pyridin-2-yl)methanone::US9896452, Ex. A166	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373408	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373408&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117728102	404342498							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741291	C[C@@H]1CCCN([C@@H]1CNc1ncc(cn1)C(F)(F)F)C(=O)c1nc(C)ccc1-c1ccccn1	InChI=1S/C24H25F3N6O/c1-15-6-5-11-33(20(15)14-31-23-29-12-17(13-30-23)24(25,26)27)22(34)21-18(9-8-16(2)32-21)19-7-3-4-10-28-19/h3-4,7-10,12-13,15,20H,5-6,11,14H2,1-2H3,(H,29,30,31)/t15-,20-/m1/s1	FKSSVKQRFCEOFB-FOIQADDNSA-N	373409	((2S,3R)-3-Methyl-2-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidin-1-yl)(6&#8242;-methyl-[2,3&#8242;-bipyridin]-2&#8242;-yl)methanone::US9896452, Ex. A167	Orexin/Hypocretin receptor type 1	Homo sapiens		 5.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373409	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373409&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727941	404342499							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741292	C[C@@H]1CCCN([C@@H]1CNc1ncc(cn1)C(F)(F)F)C(=O)c1nc(C)ccc1-c1ccccn1	InChI=1S/C24H25F3N6O/c1-15-6-5-11-33(20(15)14-31-23-29-12-17(13-30-23)24(25,26)27)22(34)21-18(9-8-16(2)32-21)19-7-3-4-10-28-19/h3-4,7-10,12-13,15,20H,5-6,11,14H2,1-2H3,(H,29,30,31)/t15-,20-/m1/s1	FKSSVKQRFCEOFB-FOIQADDNSA-N	373409	((2S,3R)-3-Methyl-2-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidin-1-yl)(6&#8242;-methyl-[2,3&#8242;-bipyridin]-2&#8242;-yl)methanone::US9896452, Ex. A167	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373409	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373409&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727941	404342499							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741293	C[C@@H]1CCCN([C@@H]1CNc1ccc(Cl)cn1)C(=O)c1nc(C)ccc1-n1cccn1	InChI=1S/C22H25ClN6O/c1-15-5-3-11-28(19(15)14-25-20-9-7-17(23)13-24-20)22(30)21-18(8-6-16(2)27-21)29-12-4-10-26-29/h4,6-10,12-13,15,19H,3,5,11,14H2,1-2H3,(H,24,25)/t15-,19-/m1/s1	CJERDRRFDFAZQE-DNVCBOLYSA-N	373410	((2S,3R)-2-(((5-Chloropyridin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(6-methyl-3-(1H-pyrazol-1-yl)pyridin-2-yl)methanone::US9896452, Ex. A168	Orexin/Hypocretin receptor type 1	Homo sapiens		 10.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373410	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373410&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727667	404342500							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741294	C[C@@H]1CCCN([C@@H]1CNc1ccc(Cl)cn1)C(=O)c1nc(C)ccc1-n1cccn1	InChI=1S/C22H25ClN6O/c1-15-5-3-11-28(19(15)14-25-20-9-7-17(23)13-24-20)22(30)21-18(8-6-16(2)27-21)29-12-4-10-26-29/h4,6-10,12-13,15,19H,3,5,11,14H2,1-2H3,(H,24,25)/t15-,19-/m1/s1	CJERDRRFDFAZQE-DNVCBOLYSA-N	373410	((2S,3R)-2-(((5-Chloropyridin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(6-methyl-3-(1H-pyrazol-1-yl)pyridin-2-yl)methanone::US9896452, Ex. A168	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373410	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373410&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727667	404342500							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741295	C[C@@H]1CCCN([C@@H]1CNc1ccc(Cl)cn1)C(=O)c1nc(C)ccc1-c1ccccn1	InChI=1S/C24H26ClN5O/c1-16-6-5-13-30(21(16)15-28-22-11-9-18(25)14-27-22)24(31)23-19(10-8-17(2)29-23)20-7-3-4-12-26-20/h3-4,7-12,14,16,21H,5-6,13,15H2,1-2H3,(H,27,28)/t16-,21-/m1/s1	ZJBABATZGBTDAI-IIBYNOLFSA-N	373411	((2S,3R)-2-(((5-Chloropyridin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(6&#8242;-methyl-[2,3&#8242;-bipyridin]-2&#8242;-yl)methanone::US9896452, Ex. A169	Orexin/Hypocretin receptor type 1	Homo sapiens		 8.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373411	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373411&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727789	404342501							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741296	C[C@@H]1CCCN([C@@H]1CNc1ccc(Cl)cn1)C(=O)c1nc(C)ccc1-c1ccccn1	InChI=1S/C24H26ClN5O/c1-16-6-5-13-30(21(16)15-28-22-11-9-18(25)14-27-22)24(31)23-19(10-8-17(2)29-23)20-7-3-4-12-26-20/h3-4,7-12,14,16,21H,5-6,13,15H2,1-2H3,(H,27,28)/t16-,21-/m1/s1	ZJBABATZGBTDAI-IIBYNOLFSA-N	373411	((2S,3R)-2-(((5-Chloropyridin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(6&#8242;-methyl-[2,3&#8242;-bipyridin]-2&#8242;-yl)methanone::US9896452, Ex. A169	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373411	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373411&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727789	404342501							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741297	C[C@@H]1CCCN([C@@H]1CNc1ncc(F)cn1)C(=O)c1cc(C)ccc1-n1nccn1	InChI=1S/C21H24FN7O/c1-14-5-6-18(29-26-7-8-27-29)17(10-14)20(30)28-9-3-4-15(2)19(28)13-25-21-23-11-16(22)12-24-21/h5-8,10-12,15,19H,3-4,9,13H2,1-2H3,(H,23,24,25)/t15-,19-/m1/s1	AOHZGKIWPQMZIL-DNVCBOLYSA-N	373412	((2S,3R)-2-(((5-Fluoropyrimidin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A171	Orexin/Hypocretin receptor type 1	Homo sapiens		 370							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373412	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373412&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727808	404342502							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741298	C[C@@H]1CCCN([C@@H]1CNc1ncc(F)cn1)C(=O)c1cc(C)ccc1-n1nccn1	InChI=1S/C21H24FN7O/c1-14-5-6-18(29-26-7-8-27-29)17(10-14)20(30)28-9-3-4-15(2)19(28)13-25-21-23-11-16(22)12-24-21/h5-8,10-12,15,19H,3-4,9,13H2,1-2H3,(H,23,24,25)/t15-,19-/m1/s1	AOHZGKIWPQMZIL-DNVCBOLYSA-N	373412	((2S,3R)-2-(((5-Fluoropyrimidin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A171	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373412	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373412&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727808	404342502							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741299	C[C@@H]1CCCN([C@@H]1CNc1ncc(F)cc1F)C(=O)c1cc(C)ccc1-n1nccn1	InChI=1S/C22H24F2N6O/c1-14-5-6-19(30-27-7-8-28-30)17(10-14)22(31)29-9-3-4-15(2)20(29)13-26-21-18(24)11-16(23)12-25-21/h5-8,10-12,15,20H,3-4,9,13H2,1-2H3,(H,25,26)/t15-,20-/m1/s1	MWUQVNQYLMESNL-FOIQADDNSA-N	373413	((2S,3R)-2-(((3,5-Difluoropyridin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A172	Orexin/Hypocretin receptor type 1	Homo sapiens		 64.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373413	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373413&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728014	404342503							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741300	C[C@@H]1CCCN([C@@H]1CNc1ncc(F)cc1F)C(=O)c1cc(C)ccc1-n1nccn1	InChI=1S/C22H24F2N6O/c1-14-5-6-19(30-27-7-8-28-30)17(10-14)22(31)29-9-3-4-15(2)20(29)13-26-21-18(24)11-16(23)12-25-21/h5-8,10-12,15,20H,3-4,9,13H2,1-2H3,(H,25,26)/t15-,20-/m1/s1	MWUQVNQYLMESNL-FOIQADDNSA-N	373413	((2S,3R)-2-(((3,5-Difluoropyridin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A172	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373413	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373413&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117728014	404342503							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741301	C[C@@H]1CCCN([C@@H]1CNc1ncc(Cl)cc1F)C(=O)c1cc(C)ccc1-n1nccn1	InChI=1S/C22H24ClFN6O/c1-14-5-6-19(30-27-7-8-28-30)17(10-14)22(31)29-9-3-4-15(2)20(29)13-26-21-18(24)11-16(23)12-25-21/h5-8,10-12,15,20H,3-4,9,13H2,1-2H3,(H,25,26)/t15-,20-/m1/s1	GWUBJSOBJGIGBO-FOIQADDNSA-N	373342	((2S,3R)-2-(((5-Chloro-3-fluoropyridin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A173::US9896452, Ex. A92	Orexin/Hypocretin receptor type 1	Homo sapiens		 1.000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373342	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373342&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727654	404342438							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741302	C[C@@H]1CCCN([C@@H]1CNc1ncc(Cl)cc1F)C(=O)c1cc(C)ccc1-n1nccn1	InChI=1S/C22H24ClFN6O/c1-14-5-6-19(30-27-7-8-28-30)17(10-14)22(31)29-9-3-4-15(2)20(29)13-26-21-18(24)11-16(23)12-25-21/h5-8,10-12,15,20H,3-4,9,13H2,1-2H3,(H,25,26)/t15-,20-/m1/s1	GWUBJSOBJGIGBO-FOIQADDNSA-N	373342	((2S,3R)-2-(((5-Chloro-3-fluoropyridin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A173::US9896452, Ex. A92	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373342	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373342&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727654	404342438							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741303	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1nc(C)ccc1-n1nccn1	InChI=1S/C22H24F3N7O/c1-14-4-3-11-31(18(14)13-27-19-8-6-16(12-26-19)22(23,24)25)21(33)20-17(7-5-15(2)30-20)32-28-9-10-29-32/h5-10,12,14,18H,3-4,11,13H2,1-2H3,(H,26,27)/t14-,18-/m1/s1	BVMLYHVIRMBSIT-RDTXWAMCSA-N	373415	((2S,3R)-3-Methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)methanone::US9896452, Ex. A174	Orexin/Hypocretin receptor type 1	Homo sapiens		 1.000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373415	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373415&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728080	404342504							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741304	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1nc(C)ccc1-n1nccn1	InChI=1S/C22H24F3N7O/c1-14-4-3-11-31(18(14)13-27-19-8-6-16(12-26-19)22(23,24)25)21(33)20-17(7-5-15(2)30-20)32-28-9-10-29-32/h5-10,12,14,18H,3-4,11,13H2,1-2H3,(H,26,27)/t14-,18-/m1/s1	BVMLYHVIRMBSIT-RDTXWAMCSA-N	373415	((2S,3R)-3-Methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)methanone::US9896452, Ex. A174	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373415	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373415&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117728080	404342504							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741305	C[C@@H]1CCCN([C@@H]1CNc1ncc(cn1)C(F)(F)F)C(=O)c1nc(C)ccc1-n1nccn1	InChI=1S/C21H23F3N8O/c1-13-4-3-9-31(17(13)12-27-20-25-10-15(11-26-20)21(22,23)24)19(33)18-16(6-5-14(2)30-18)32-28-7-8-29-32/h5-8,10-11,13,17H,3-4,9,12H2,1-2H3,(H,25,26,27)/t13-,17-/m1/s1	JZUGYYPKJKQEMG-CXAGYDPISA-N	373416	((2S,3R)-3-Methyl-2-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidin-1-yl)(6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)methanone::US9896452, Ex. A175	Orexin/Hypocretin receptor type 1	Homo sapiens		 1.000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373416	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373416&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727903	404342505							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741306	C[C@@H]1CCCN([C@@H]1CNc1ncc(cn1)C(F)(F)F)C(=O)c1nc(C)ccc1-n1nccn1	InChI=1S/C21H23F3N8O/c1-13-4-3-9-31(17(13)12-27-20-25-10-15(11-26-20)21(22,23)24)19(33)18-16(6-5-14(2)30-18)32-28-7-8-29-32/h5-8,10-11,13,17H,3-4,9,12H2,1-2H3,(H,25,26,27)/t13-,17-/m1/s1	JZUGYYPKJKQEMG-CXAGYDPISA-N	373416	((2S,3R)-3-Methyl-2-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidin-1-yl)(6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)methanone::US9896452, Ex. A175	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373416	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373416&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727903	404342505							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741307	C[C@@H]1CCCN([C@@H]1CNc1ccc(nn1)C(F)(F)F)C(=O)c1nc(C)ccc1-n1nccn1	InChI=1S/C21H23F3N8O/c1-13-4-3-11-31(16(13)12-25-18-8-7-17(29-30-18)21(22,23)24)20(33)19-15(6-5-14(2)28-19)32-26-9-10-27-32/h5-10,13,16H,3-4,11-12H2,1-2H3,(H,25,30)/t13-,16-/m1/s1	LJTLOJZYSKVQQY-CZUORRHYSA-N	373417	((2S,3R)-3-Methyl-2-(((6-(trifluoromethyl)pyridazin-3-yl)amino)methyl)piperidin-1-yl)(6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)methanone::US9896452, Ex. A176	Orexin/Hypocretin receptor type 1	Homo sapiens		 6.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373417	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373417&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728079	404342506							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741308	C[C@@H]1CCCN([C@@H]1CNc1ccc(nn1)C(F)(F)F)C(=O)c1nc(C)ccc1-n1nccn1	InChI=1S/C21H23F3N8O/c1-13-4-3-11-31(16(13)12-25-18-8-7-17(29-30-18)21(22,23)24)20(33)19-15(6-5-14(2)28-19)32-26-9-10-27-32/h5-10,13,16H,3-4,11-12H2,1-2H3,(H,25,30)/t13-,16-/m1/s1	LJTLOJZYSKVQQY-CZUORRHYSA-N	373417	((2S,3R)-3-Methyl-2-(((6-(trifluoromethyl)pyridazin-3-yl)amino)methyl)piperidin-1-yl)(6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)methanone::US9896452, Ex. A176	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373417	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373417&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117728079	404342506							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741309	C[C@@H]1CCCN([C@@H]1CNc1ncc(Cl)cn1)C(=O)c1nc(C)ccc1-n1nccn1	InChI=1S/C20H23ClN8O/c1-13-4-3-9-28(17(13)12-24-20-22-10-15(21)11-23-20)19(30)18-16(6-5-14(2)27-18)29-25-7-8-26-29/h5-8,10-11,13,17H,3-4,9,12H2,1-2H3,(H,22,23,24)/t13-,17-/m1/s1	QTTLIYGWTNCOEE-CXAGYDPISA-N	373418	((2S,3R)-2-(((5-Chloropyrimidin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)methanone::US9896452, Ex. A177	Orexin/Hypocretin receptor type 1	Homo sapiens		 5.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373418	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373418&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728109	404342507							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741310	C[C@@H]1CCCN([C@@H]1CNc1ncc(Cl)cn1)C(=O)c1nc(C)ccc1-n1nccn1	InChI=1S/C20H23ClN8O/c1-13-4-3-9-28(17(13)12-24-20-22-10-15(21)11-23-20)19(30)18-16(6-5-14(2)27-18)29-25-7-8-26-29/h5-8,10-11,13,17H,3-4,9,12H2,1-2H3,(H,22,23,24)/t13-,17-/m1/s1	QTTLIYGWTNCOEE-CXAGYDPISA-N	373418	((2S,3R)-2-(((5-Chloropyrimidin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)methanone::US9896452, Ex. A177	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373418	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373418&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117728109	404342507							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741311	C[C@@H]1CCCN([C@@H]1CNc1ccc(Cl)cn1)C(=O)c1nc(C)ccc1-n1nccn1	InChI=1S/C21H24ClN7O/c1-14-4-3-11-28(18(14)13-24-19-8-6-16(22)12-23-19)21(30)20-17(7-5-15(2)27-20)29-25-9-10-26-29/h5-10,12,14,18H,3-4,11,13H2,1-2H3,(H,23,24)/t14-,18-/m1/s1	GMDAZMLAWHSJRK-RDTXWAMCSA-N	373419	((2S,3R)-2-(((5-Chloropyridin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)methanone::US9896452, Ex. A178	Orexin/Hypocretin receptor type 1	Homo sapiens		 4.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373419	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373419&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727737	404342508							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741312	C[C@@H]1CCCN([C@@H]1CNc1ccc(Cl)cn1)C(=O)c1nc(C)ccc1-n1nccn1	InChI=1S/C21H24ClN7O/c1-14-4-3-11-28(18(14)13-24-19-8-6-16(22)12-23-19)21(30)20-17(7-5-15(2)27-20)29-25-9-10-26-29/h5-10,12,14,18H,3-4,11,13H2,1-2H3,(H,23,24)/t14-,18-/m1/s1	GMDAZMLAWHSJRK-RDTXWAMCSA-N	373419	((2S,3R)-2-(((5-Chloropyridin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)methanone::US9896452, Ex. A178	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373419	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373419&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727737	404342508							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741313	C[C@@H]1CCCN([C@@H]1CNc1ncc(F)cn1)C(=O)c1cc(C)ccc1-c1ccccn1	InChI=1S/C24H26FN5O/c1-16-8-9-19(21-7-3-4-10-26-21)20(12-16)23(31)30-11-5-6-17(2)22(30)15-29-24-27-13-18(25)14-28-24/h3-4,7-10,12-14,17,22H,5-6,11,15H2,1-2H3,(H,27,28,29)/t17-,22-/m1/s1	AWAKPXPQECZJHS-VGOFRKELSA-N	373420	((2S,3R)-2-(((5-Fluoropyrimidin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(pyridin-2-yl)phenyl)methanone::US9896452, Ex. A179	Orexin/Hypocretin receptor type 1	Homo sapiens		 490							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373420	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373420&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728393	404342509							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741314	C[C@@H]1CCCN([C@@H]1CNc1ncc(F)cn1)C(=O)c1cc(C)ccc1-c1ccccn1	InChI=1S/C24H26FN5O/c1-16-8-9-19(21-7-3-4-10-26-21)20(12-16)23(31)30-11-5-6-17(2)22(30)15-29-24-27-13-18(25)14-28-24/h3-4,7-10,12-14,17,22H,5-6,11,15H2,1-2H3,(H,27,28,29)/t17-,22-/m1/s1	AWAKPXPQECZJHS-VGOFRKELSA-N	373420	((2S,3R)-2-(((5-Fluoropyrimidin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(pyridin-2-yl)phenyl)methanone::US9896452, Ex. A179	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373420	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373420&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117728393	404342509							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741315	C[C@@H]1CCCN([C@@H]1CNc1nc2ccccc2o1)C(=O)c1cc(C)ccc1-n1nccn1	InChI=1S/C24H26N6O2/c1-16-9-10-20(30-26-11-12-27-30)18(14-16)23(31)29-13-5-6-17(2)21(29)15-25-24-28-19-7-3-4-8-22(19)32-24/h3-4,7-12,14,17,21H,5-6,13,15H2,1-2H3,(H,25,28)/t17-,21-/m1/s1	XICYINDZEAEGIE-DYESRHJHSA-N	373421	((2S,3R)-2-((Benzo[d]oxazol-2-ylamino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A180	Orexin/Hypocretin receptor type 1	Homo sapiens		 4.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373421	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373421&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728114	404342510							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741316	C[C@@H]1CCCN([C@@H]1CNc1nc2ccccc2o1)C(=O)c1cc(C)ccc1-n1nccn1	InChI=1S/C24H26N6O2/c1-16-9-10-20(30-26-11-12-27-30)18(14-16)23(31)29-13-5-6-17(2)21(29)15-25-24-28-19-7-3-4-8-22(19)32-24/h3-4,7-12,14,17,21H,5-6,13,15H2,1-2H3,(H,25,28)/t17-,21-/m1/s1	XICYINDZEAEGIE-DYESRHJHSA-N	373421	((2S,3R)-2-((Benzo[d]oxazol-2-ylamino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A180	Orexin receptor type 2	Homo sapiens		 160							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373421	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373421&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117728114	404342510							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741317	C[C@@H]1CCCN([C@@H]1CNc1ncc(Cl)cc1F)C(=O)c1cc(C)ccc1-c1ncccn1	InChI=1S/C24H25ClFN5O/c1-15-6-7-18(22-27-8-4-9-28-22)19(11-15)24(32)31-10-3-5-16(2)21(31)14-30-23-20(26)12-17(25)13-29-23/h4,6-9,11-13,16,21H,3,5,10,14H2,1-2H3,(H,29,30)/t16-,21-/m1/s1	AFAXRUDWPAJYOI-IIBYNOLFSA-N	373422	((2S,3R)-2-(((5-Chloro-3-fluoropyridin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(pyrimidin-2-yl)phenyl)methanone::US9896452, Ex. A181	Orexin/Hypocretin receptor type 1	Homo sapiens		 4.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373422	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373422&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727778	404342511							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741318	C[C@@H]1CCCN([C@@H]1CNc1ncc(Cl)cc1F)C(=O)c1cc(C)ccc1-c1ncccn1	InChI=1S/C24H25ClFN5O/c1-15-6-7-18(22-27-8-4-9-28-22)19(11-15)24(32)31-10-3-5-16(2)21(31)14-30-23-20(26)12-17(25)13-29-23/h4,6-9,11-13,16,21H,3,5,10,14H2,1-2H3,(H,29,30)/t16-,21-/m1/s1	AFAXRUDWPAJYOI-IIBYNOLFSA-N	373422	((2S,3R)-2-(((5-Chloro-3-fluoropyridin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(pyrimidin-2-yl)phenyl)methanone::US9896452, Ex. A181	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373422	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373422&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727778	404342511							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741319	C[C@@H]1CCCN([C@@H]1CNc1ncc(F)cc1F)C(=O)c1cc(C)ccc1-c1ncccn1	InChI=1S/C24H25F2N5O/c1-15-6-7-18(22-27-8-4-9-28-22)19(11-15)24(32)31-10-3-5-16(2)21(31)14-30-23-20(26)12-17(25)13-29-23/h4,6-9,11-13,16,21H,3,5,10,14H2,1-2H3,(H,29,30)/t16-,21-/m1/s1	XOZXYXIDMIHDOT-IIBYNOLFSA-N	373423	((2S,3R)-2-(((3,5-Difluoropyridin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(pyrimidin-2-yl)phenyl)methanone::US9896452, Ex. A182	Orexin/Hypocretin receptor type 1	Homo sapiens		 140							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373423	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373423&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728273	404342512							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741320	C[C@@H]1CCCN([C@@H]1CNc1ncc(F)cc1F)C(=O)c1cc(C)ccc1-c1ncccn1	InChI=1S/C24H25F2N5O/c1-15-6-7-18(22-27-8-4-9-28-22)19(11-15)24(32)31-10-3-5-16(2)21(31)14-30-23-20(26)12-17(25)13-29-23/h4,6-9,11-13,16,21H,3,5,10,14H2,1-2H3,(H,29,30)/t16-,21-/m1/s1	XOZXYXIDMIHDOT-IIBYNOLFSA-N	373423	((2S,3R)-2-(((3,5-Difluoropyridin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(pyrimidin-2-yl)phenyl)methanone::US9896452, Ex. A182	Orexin receptor type 2	Homo sapiens		 4000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373423	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373423&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117728273	404342512							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741321	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1nc(C)ccc1-c1ncccn1	InChI=1S/C24H25F3N6O/c1-15-5-3-12-33(19(15)14-31-20-9-7-17(13-30-20)24(25,26)27)23(34)21-18(8-6-16(2)32-21)22-28-10-4-11-29-22/h4,6-11,13,15,19H,3,5,12,14H2,1-2H3,(H,30,31)/t15-,19-/m1/s1	AIAHNKPXRXURRU-DNVCBOLYSA-N	373424	((2S,3R)-3-Methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(6-methyl-3-(pyrimidin-2-yl)pyridin-2-yl)methanone::US9896452, Ex. A183	Orexin/Hypocretin receptor type 1	Homo sapiens		 3.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373424	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373424&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728224	404342513							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741322	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1nc(C)ccc1-c1ncccn1	InChI=1S/C24H25F3N6O/c1-15-5-3-12-33(19(15)14-31-20-9-7-17(13-30-20)24(25,26)27)23(34)21-18(8-6-16(2)32-21)22-28-10-4-11-29-22/h4,6-11,13,15,19H,3,5,12,14H2,1-2H3,(H,30,31)/t15-,19-/m1/s1	AIAHNKPXRXURRU-DNVCBOLYSA-N	373424	((2S,3R)-3-Methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(6-methyl-3-(pyrimidin-2-yl)pyridin-2-yl)methanone::US9896452, Ex. A183	Orexin receptor type 2	Homo sapiens		 4000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373424	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373424&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117728224	404342513							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741323	C[C@@H]1CCCN([C@@H]1CNc1ncc(cn1)C(F)(F)F)C(=O)c1nc(C)ccc1-c1ncccn1	InChI=1S/C23H24F3N7O/c1-14-5-3-10-33(18(14)13-31-22-29-11-16(12-30-22)23(24,25)26)21(34)19-17(7-6-15(2)32-19)20-27-8-4-9-28-20/h4,6-9,11-12,14,18H,3,5,10,13H2,1-2H3,(H,29,30,31)/t14-,18-/m1/s1	UBDAMZPPOURCBV-RDTXWAMCSA-N	373425	((2S,3R)-3-Methyl-2-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidin-1-yl)(6-methyl-3-(pyrimidin-2-yl)pyridin-2-yl)methanone::US9896452, Ex. A184	Orexin/Hypocretin receptor type 1	Homo sapiens		 5.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373425	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373425&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727733	404342514							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741324	C[C@@H]1CCCN([C@@H]1CNc1ncc(cn1)C(F)(F)F)C(=O)c1nc(C)ccc1-c1ncccn1	InChI=1S/C23H24F3N7O/c1-14-5-3-10-33(18(14)13-31-22-29-11-16(12-30-22)23(24,25)26)21(34)19-17(7-6-15(2)32-19)20-27-8-4-9-28-20/h4,6-9,11-12,14,18H,3,5,10,13H2,1-2H3,(H,29,30,31)/t14-,18-/m1/s1	UBDAMZPPOURCBV-RDTXWAMCSA-N	373425	((2S,3R)-3-Methyl-2-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidin-1-yl)(6-methyl-3-(pyrimidin-2-yl)pyridin-2-yl)methanone::US9896452, Ex. A184	Orexin receptor type 2	Homo sapiens		 2500							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373425	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373425&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727733	404342514							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741325	C[C@@H]1CCCN([C@@H]1CNc1ccc(nn1)C(F)(F)F)C(=O)c1nc(C)ccc1-c1ncccn1	InChI=1S/C23H24F3N7O/c1-14-5-3-12-33(17(14)13-29-19-9-8-18(31-32-19)23(24,25)26)22(34)20-16(7-6-15(2)30-20)21-27-10-4-11-28-21/h4,6-11,14,17H,3,5,12-13H2,1-2H3,(H,29,32)/t14-,17-/m1/s1	JHTCOYRDBNZOHT-RHSMWYFYSA-N	373426	((2S,3R)-3-Methyl-2-(((6-(trifluoromethyl)pyridazin-3-yl)amino)methyl)piperidin-1-yl)(6-methyl-3-(pyrimidin-2-yl)pyridin-2-yl)methanone::US9896452, Ex. A185	Orexin/Hypocretin receptor type 1	Homo sapiens		 46.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373426	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373426&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728112	404342515							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741326	C[C@@H]1CCCN([C@@H]1CNc1ccc(nn1)C(F)(F)F)C(=O)c1nc(C)ccc1-c1ncccn1	InChI=1S/C23H24F3N7O/c1-14-5-3-12-33(17(14)13-29-19-9-8-18(31-32-19)23(24,25)26)22(34)20-16(7-6-15(2)30-20)21-27-10-4-11-28-21/h4,6-11,14,17H,3,5,12-13H2,1-2H3,(H,29,32)/t14-,17-/m1/s1	JHTCOYRDBNZOHT-RHSMWYFYSA-N	373426	((2S,3R)-3-Methyl-2-(((6-(trifluoromethyl)pyridazin-3-yl)amino)methyl)piperidin-1-yl)(6-methyl-3-(pyrimidin-2-yl)pyridin-2-yl)methanone::US9896452, Ex. A185	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373426	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373426&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117728112	404342515							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741327	C[C@@H]1CCCN([C@@H]1CNc1ccc(Cl)cn1)C(=O)c1nc(C)ccc1-c1ncccn1	InChI=1S/C23H25ClN6O/c1-15-5-3-12-30(19(15)14-28-20-9-7-17(24)13-27-20)23(31)21-18(8-6-16(2)29-21)22-25-10-4-11-26-22/h4,6-11,13,15,19H,3,5,12,14H2,1-2H3,(H,27,28)/t15-,19-/m1/s1	SZHZMTWOKFVWTM-DNVCBOLYSA-N	373427	((2S,3R)-2-(((5-chloropyridin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(6-methyl-3-(pyrimidin-2-yl)pyridin-2-yl)methanone::US9896452, Ex. A186	Orexin/Hypocretin receptor type 1	Homo sapiens		 5.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373427	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373427&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728229	404342516							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741328	C[C@@H]1CCCN([C@@H]1CNc1ccc(Cl)cn1)C(=O)c1nc(C)ccc1-c1ncccn1	InChI=1S/C23H25ClN6O/c1-15-5-3-12-30(19(15)14-28-20-9-7-17(24)13-27-20)23(31)21-18(8-6-16(2)29-21)22-25-10-4-11-26-22/h4,6-11,13,15,19H,3,5,12,14H2,1-2H3,(H,27,28)/t15-,19-/m1/s1	SZHZMTWOKFVWTM-DNVCBOLYSA-N	373427	((2S,3R)-2-(((5-chloropyridin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(6-methyl-3-(pyrimidin-2-yl)pyridin-2-yl)methanone::US9896452, Ex. A186	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373427	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373427&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117728229	404342516							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741329	C[C@@H]1CCCN([C@@H]1CNc1nnc(s1)C(F)(F)F)C(=O)c1nc(C)ccc1-c1ncccn1	InChI=1S/C21H22F3N7OS/c1-12-5-3-10-31(15(12)11-27-20-30-29-19(33-20)21(22,23)24)18(32)16-14(7-6-13(2)28-16)17-25-8-4-9-26-17/h4,6-9,12,15H,3,5,10-11H2,1-2H3,(H,27,30)/t12-,15-/m1/s1	BAEJQDZBHBROMJ-IUODEOHRSA-N	373428	((2S,3R)-3-Methyl-2-(((5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl)amino)methyl)piperidin-1-yl)(6-methyl-3-(pyrimidin-2-yl)pyridin-2-yl)methanone::US9896452, Ex. A187	Orexin/Hypocretin receptor type 1	Homo sapiens		 200							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373428	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373428&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727947	404342517							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741330	C[C@@H]1CCCN([C@@H]1CNc1nnc(s1)C(F)(F)F)C(=O)c1nc(C)ccc1-c1ncccn1	InChI=1S/C21H22F3N7OS/c1-12-5-3-10-31(15(12)11-27-20-30-29-19(33-20)21(22,23)24)18(32)16-14(7-6-13(2)28-16)17-25-8-4-9-26-17/h4,6-9,12,15H,3,5,10-11H2,1-2H3,(H,27,30)/t12-,15-/m1/s1	BAEJQDZBHBROMJ-IUODEOHRSA-N	373428	((2S,3R)-3-Methyl-2-(((5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl)amino)methyl)piperidin-1-yl)(6-methyl-3-(pyrimidin-2-yl)pyridin-2-yl)methanone::US9896452, Ex. A187	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373428	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373428&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727947	404342517							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741331	C[C@@H]1CCCN([C@@H]1CNc1ncc(cc1F)C(F)(F)F)C(=O)c1nc(C)ccc1-n1nccn1	InChI=1S/C22H23F4N7O/c1-13-4-3-9-32(18(13)12-28-20-16(23)10-15(11-27-20)22(24,25)26)21(34)19-17(6-5-14(2)31-19)33-29-7-8-30-33/h5-8,10-11,13,18H,3-4,9,12H2,1-2H3,(H,27,28)/t13-,18-/m1/s1	KQJQPFUMQSFPQA-FZKQIMNGSA-N	373429	((2S,3R)-2-(((3-Fluoro-5-(trifluoromethyl)pyridin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)methanone::US9896452, Ex. A188	Orexin/Hypocretin receptor type 1	Homo sapiens		 1.000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373429	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373429&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727686	404342518							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741332	C[C@@H]1CCCN([C@@H]1CNc1ncc(cc1F)C(F)(F)F)C(=O)c1nc(C)ccc1-n1nccn1	InChI=1S/C22H23F4N7O/c1-13-4-3-9-32(18(13)12-28-20-16(23)10-15(11-27-20)22(24,25)26)21(34)19-17(6-5-14(2)31-19)33-29-7-8-30-33/h5-8,10-11,13,18H,3-4,9,12H2,1-2H3,(H,27,28)/t13-,18-/m1/s1	KQJQPFUMQSFPQA-FZKQIMNGSA-N	373429	((2S,3R)-2-(((3-Fluoro-5-(trifluoromethyl)pyridin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)methanone::US9896452, Ex. A188	Orexin receptor type 2	Homo sapiens		 2300							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373429	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373429&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727686	404342518							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741333	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C#N)C(=O)c1nc(C)ccc1-n1nccn1	InChI=1S/C22H24N8O/c1-15-4-3-11-29(19(15)14-25-20-8-6-17(12-23)13-24-20)22(31)21-18(7-5-16(2)28-21)30-26-9-10-27-30/h5-10,13,15,19H,3-4,11,14H2,1-2H3,(H,24,25)/t15-,19-/m1/s1	JNSOWRQKOMDFFS-DNVCBOLYSA-N	373430	6-((((2S,3R)-3-Methyl-1-(6-methyl-3-(2H-1,2,3-triazol-2-yl)picolinoyl)piperidin-2-yl)methyl)amino)nicotinonitrile::US9896452, Ex. A189	Orexin/Hypocretin receptor type 1	Homo sapiens		 120							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373430	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373430&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728147	404342519							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741334	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C#N)C(=O)c1nc(C)ccc1-n1nccn1	InChI=1S/C22H24N8O/c1-15-4-3-11-29(19(15)14-25-20-8-6-17(12-23)13-24-20)22(31)21-18(7-5-16(2)28-21)30-26-9-10-27-30/h5-10,13,15,19H,3-4,11,14H2,1-2H3,(H,24,25)/t15-,19-/m1/s1	JNSOWRQKOMDFFS-DNVCBOLYSA-N	373430	6-((((2S,3R)-3-Methyl-1-(6-methyl-3-(2H-1,2,3-triazol-2-yl)picolinoyl)piperidin-2-yl)methyl)amino)nicotinonitrile::US9896452, Ex. A189	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373430	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373430&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117728147	404342519							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741335	C[C@@H]1CCCN([C@@H]1CNc1ncc(cn1)C#N)C(=O)c1nc(C)ccc1-n1nccn1	InChI=1S/C21H23N9O/c1-14-4-3-9-29(18(14)13-25-21-23-11-16(10-22)12-24-21)20(31)19-17(6-5-15(2)28-19)30-26-7-8-27-30/h5-8,11-12,14,18H,3-4,9,13H2,1-2H3,(H,23,24,25)/t14-,18-/m1/s1	ZKGAAERIFLQKJV-RDTXWAMCSA-N	373431	2-((((2S,3R)-3-Methyl-1-(6-methyl-3-(2H-1,2,3-triazol-2-yl)picolinoyl)piperidin-2-yl)methyl)amino)pyrimidine-5-carbonitrile::US9896452, Ex. A190	Orexin/Hypocretin receptor type 1	Homo sapiens		 2000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373431	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373431&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727644	404342520							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741336	C[C@@H]1CCCN([C@@H]1CNc1ncc(cn1)C#N)C(=O)c1nc(C)ccc1-n1nccn1	InChI=1S/C21H23N9O/c1-14-4-3-9-29(18(14)13-25-21-23-11-16(10-22)12-24-21)20(31)19-17(6-5-15(2)28-19)30-26-7-8-27-30/h5-8,11-12,14,18H,3-4,9,13H2,1-2H3,(H,23,24,25)/t14-,18-/m1/s1	ZKGAAERIFLQKJV-RDTXWAMCSA-N	373431	2-((((2S,3R)-3-Methyl-1-(6-methyl-3-(2H-1,2,3-triazol-2-yl)picolinoyl)piperidin-2-yl)methyl)amino)pyrimidine-5-carbonitrile::US9896452, Ex. A190	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373431	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373431&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727644	404342520							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741337	C[C@@H]1CCCN([C@@H]1CNc1nnc(s1)C(F)(F)F)C(=O)c1nc(C)ccc1-n1nccn1	InChI=1S/C19H21F3N8OS/c1-11-4-3-9-29(14(11)10-23-18-28-27-17(32-18)19(20,21)22)16(31)15-13(6-5-12(2)26-15)30-24-7-8-25-30/h5-8,11,14H,3-4,9-10H2,1-2H3,(H,23,28)/t11-,14-/m1/s1	XZHWUADFCRIQAJ-BXUZGUMPSA-N	373432	((2S,3R)-3-Methyl-2-(((5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl)amino)methyl)piperidin-1-yl)(6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)methanone::US9896452, Ex. A191	Orexin/Hypocretin receptor type 1	Homo sapiens		 43.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373432	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373432&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728125	404342521							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741338	C[C@@H]1CCCN([C@@H]1CNc1nnc(s1)C(F)(F)F)C(=O)c1nc(C)ccc1-n1nccn1	InChI=1S/C19H21F3N8OS/c1-11-4-3-9-29(14(11)10-23-18-28-27-17(32-18)19(20,21)22)16(31)15-13(6-5-12(2)26-15)30-24-7-8-25-30/h5-8,11,14H,3-4,9-10H2,1-2H3,(H,23,28)/t11-,14-/m1/s1	XZHWUADFCRIQAJ-BXUZGUMPSA-N	373432	((2S,3R)-3-Methyl-2-(((5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl)amino)methyl)piperidin-1-yl)(6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)methanone::US9896452, Ex. A191	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373432	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373432&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117728125	404342521							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741339	C[C@@H]1CCCN([C@@H]1CNc1ncc(cc1F)C#N)C(=O)c1nc(C)ccc1-n1nccn1	InChI=1S/C22H23FN8O/c1-14-4-3-9-30(19(14)13-26-21-17(23)10-16(11-24)12-25-21)22(32)20-18(6-5-15(2)29-20)31-27-7-8-28-31/h5-8,10,12,14,19H,3-4,9,13H2,1-2H3,(H,25,26)/t14-,19-/m1/s1	ZHEJYTZBJONODD-AUUYWEPGSA-N	373433	5-Fluoro-6-((((2S,3R)-3-methyl-1-(6-methyl-3-(2H-1,2,3-triazol-2-yl)picolinoyl)piperidin-2-yl)methyl)amino)nicotinonitrile::US9896452, Ex. A193	Orexin/Hypocretin receptor type 1	Homo sapiens		 100.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373433	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373433&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728161	404342522							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741340	C[C@@H]1CCCN([C@@H]1CNc1ncc(cc1F)C#N)C(=O)c1nc(C)ccc1-n1nccn1	InChI=1S/C22H23FN8O/c1-14-4-3-9-30(19(14)13-26-21-17(23)10-16(11-24)12-25-21)22(32)20-18(6-5-15(2)29-20)31-27-7-8-28-31/h5-8,10,12,14,19H,3-4,9,13H2,1-2H3,(H,25,26)/t14-,19-/m1/s1	ZHEJYTZBJONODD-AUUYWEPGSA-N	373433	5-Fluoro-6-((((2S,3R)-3-methyl-1-(6-methyl-3-(2H-1,2,3-triazol-2-yl)picolinoyl)piperidin-2-yl)methyl)amino)nicotinonitrile::US9896452, Ex. A193	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373433	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373433&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117728161	404342522							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741341	C[C@@H]1CCCN([C@@H]1CN(C)c1ccc(cn1)C(F)(F)F)C(=O)c1nc(C)ccc1-n1nccn1	InChI=1S/C23H26F3N7O/c1-15-5-4-12-32(19(15)14-31(3)20-9-7-17(13-27-20)23(24,25)26)22(34)21-18(8-6-16(2)30-21)33-28-10-11-29-33/h6-11,13,15,19H,4-5,12,14H2,1-3H3/t15-,19-/m1/s1	QVIJSBXDLWKHDC-DNVCBOLYSA-N	373434	((2S,3R)-3-Methyl-2-((methyl(5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)methanone::US9896452, Ex. A194	Orexin/Hypocretin receptor type 1	Homo sapiens		 6.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373434	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373434&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727658	404342523							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741342	C[C@@H]1CCCN([C@@H]1CN(C)c1ccc(cn1)C(F)(F)F)C(=O)c1nc(C)ccc1-n1nccn1	InChI=1S/C23H26F3N7O/c1-15-5-4-12-32(19(15)14-31(3)20-9-7-17(13-27-20)23(24,25)26)22(34)21-18(8-6-16(2)30-21)33-28-10-11-29-33/h6-11,13,15,19H,4-5,12,14H2,1-3H3/t15-,19-/m1/s1	QVIJSBXDLWKHDC-DNVCBOLYSA-N	373434	((2S,3R)-3-Methyl-2-((methyl(5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)methanone::US9896452, Ex. A194	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373434	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373434&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727658	404342523							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741343	C[C@@H]1CCCN([C@@H]1CNc1nc2cc(Cl)ccc2o1)C(=O)c1nc(C)ccc1-n1nccn1	InChI=1S/C23H24ClN7O2/c1-14-4-3-11-30(19(14)13-25-23-29-17-12-16(24)6-8-20(17)33-23)22(32)21-18(7-5-15(2)28-21)31-26-9-10-27-31/h5-10,12,14,19H,3-4,11,13H2,1-2H3,(H,25,29)/t14-,19-/m1/s1	DBDQRJSDHDMDBC-AUUYWEPGSA-N	373435	((2S,3R)-2-(((5-Chlorobenzo[d]oxazol-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)methanone::US9896452, Ex. A195	Orexin/Hypocretin receptor type 1	Homo sapiens		 4.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373435	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373435&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728033	404342524							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741344	C[C@@H]1CCCN([C@@H]1CNc1nc2cc(Cl)ccc2o1)C(=O)c1nc(C)ccc1-n1nccn1	InChI=1S/C23H24ClN7O2/c1-14-4-3-11-30(19(14)13-25-23-29-17-12-16(24)6-8-20(17)33-23)22(32)21-18(7-5-15(2)28-21)31-26-9-10-27-31/h5-10,12,14,19H,3-4,11,13H2,1-2H3,(H,25,29)/t14-,19-/m1/s1	DBDQRJSDHDMDBC-AUUYWEPGSA-N	373435	((2S,3R)-2-(((5-Chlorobenzo[d]oxazol-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)methanone::US9896452, Ex. A195	Orexin receptor type 2	Homo sapiens		 389							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373435	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373435&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117728033	404342524							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741345	C[C@@H]1CCCN([C@@H]1CNc1ccc(C)cn1)C(=O)c1nc(C)ccc1-n1nccn1	InChI=1S/C22H27N7O/c1-15-6-9-20(23-13-15)24-14-19-16(2)5-4-12-28(19)22(30)21-18(8-7-17(3)27-21)29-25-10-11-26-29/h6-11,13,16,19H,4-5,12,14H2,1-3H3,(H,23,24)/t16-,19-/m1/s1	CFYSMVSUBYXIHB-VQIMIIECSA-N	373436	((2S,3R)-3-Methyl-2-(((5-methylpyridin-2-yl)amino)methyl)piperidin-1-yl)(6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)methanone::US9896452, Ex. A196	Orexin/Hypocretin receptor type 1	Homo sapiens		 17.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373436	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373436&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727776	404342525							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741346	C[C@@H]1CCCN([C@@H]1CNc1ccc(C)cn1)C(=O)c1nc(C)ccc1-n1nccn1	InChI=1S/C22H27N7O/c1-15-6-9-20(23-13-15)24-14-19-16(2)5-4-12-28(19)22(30)21-18(8-7-17(3)27-21)29-25-10-11-26-29/h6-11,13,16,19H,4-5,12,14H2,1-3H3,(H,23,24)/t16-,19-/m1/s1	CFYSMVSUBYXIHB-VQIMIIECSA-N	373436	((2S,3R)-3-Methyl-2-(((5-methylpyridin-2-yl)amino)methyl)piperidin-1-yl)(6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)methanone::US9896452, Ex. A196	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373436	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373436&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727776	404342525							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741347	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1cc(C)ccc1-c1cccnn1	InChI=1S/C25H26F3N5O/c1-16-7-9-19(21-6-3-11-31-32-21)20(13-16)24(34)33-12-4-5-17(2)22(33)15-30-23-10-8-18(14-29-23)25(26,27)28/h3,6-11,13-14,17,22H,4-5,12,15H2,1-2H3,(H,29,30)/t17-,22-/m1/s1	ACOMRCGXBFTVES-VGOFRKELSA-N	373437	((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(pyridazin-3-yl)phenyl)methanone::US9896452, Ex. A197	Orexin/Hypocretin receptor type 1	Homo sapiens		 7.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373437	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373437&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728061	404342526							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741348	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1cc(C)ccc1-c1cccnn1	InChI=1S/C25H26F3N5O/c1-16-7-9-19(21-6-3-11-31-32-21)20(13-16)24(34)33-12-4-5-17(2)22(33)15-30-23-10-8-18(14-29-23)25(26,27)28/h3,6-11,13-14,17,22H,4-5,12,15H2,1-2H3,(H,29,30)/t17-,22-/m1/s1	ACOMRCGXBFTVES-VGOFRKELSA-N	373437	((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(pyridazin-3-yl)phenyl)methanone::US9896452, Ex. A197	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373437	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373437&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117728061	404342526							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741349	C[C@@H]1CCCN([C@@H]1CNc1ncc(cn1)C(F)(F)F)C(=O)c1cc(C)ccc1-c1cccnn1	InChI=1S/C24H25F3N6O/c1-15-7-8-18(20-6-3-9-31-32-20)19(11-15)22(34)33-10-4-5-16(2)21(33)14-30-23-28-12-17(13-29-23)24(25,26)27/h3,6-9,11-13,16,21H,4-5,10,14H2,1-2H3,(H,28,29,30)/t16-,21-/m1/s1	CFOAGYOQMAJOKH-IIBYNOLFSA-N	373438	((2S,3R)-3-Methyl-2-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(pyridazin-3-yl)phenyl)methanone::US9896452, Ex. A198	Orexin/Hypocretin receptor type 1	Homo sapiens		 5.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373438	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373438&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728235	404342527							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741350	C[C@@H]1CCCN([C@@H]1CNc1ncc(cn1)C(F)(F)F)C(=O)c1cc(C)ccc1-c1cccnn1	InChI=1S/C24H25F3N6O/c1-15-7-8-18(20-6-3-9-31-32-20)19(11-15)22(34)33-10-4-5-16(2)21(33)14-30-23-28-12-17(13-29-23)24(25,26)27/h3,6-9,11-13,16,21H,4-5,10,14H2,1-2H3,(H,28,29,30)/t16-,21-/m1/s1	CFOAGYOQMAJOKH-IIBYNOLFSA-N	373438	((2S,3R)-3-Methyl-2-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(pyridazin-3-yl)phenyl)methanone::US9896452, Ex. A198	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373438	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373438&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117728235	404342527							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741351	C[C@@H]1CCCN([C@@H]1CNc1nc2cc(Cl)ccc2o1)C(=O)c1nc(C)ccc1-c1ccccn1	InChI=1S/C26H26ClN5O2/c1-16-6-5-13-32(22(16)15-29-26-31-21-14-18(27)9-11-23(21)34-26)25(33)24-19(10-8-17(2)30-24)20-7-3-4-12-28-20/h3-4,7-12,14,16,22H,5-6,13,15H2,1-2H3,(H,29,31)/t16-,22-/m1/s1	SVIFTVOTHDCJFS-OPAMFIHVSA-N	373439	((2S,3R)-2-(((5-Chlorobenzo[d]oxazol-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(6&#8242;-methyl-[2,3&#8242;-bipyridin]-2&#8242;-yl)methanone::US9896452, Ex. A199	Orexin/Hypocretin receptor type 1	Homo sapiens		 15.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373439	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373439&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727917	404342528							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741352	C[C@@H]1CCCN([C@@H]1CNc1nc2cc(Cl)ccc2o1)C(=O)c1nc(C)ccc1-c1ccccn1	InChI=1S/C26H26ClN5O2/c1-16-6-5-13-32(22(16)15-29-26-31-21-14-18(27)9-11-23(21)34-26)25(33)24-19(10-8-17(2)30-24)20-7-3-4-12-28-20/h3-4,7-12,14,16,22H,5-6,13,15H2,1-2H3,(H,29,31)/t16-,22-/m1/s1	SVIFTVOTHDCJFS-OPAMFIHVSA-N	373439	((2S,3R)-2-(((5-Chlorobenzo[d]oxazol-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(6&#8242;-methyl-[2,3&#8242;-bipyridin]-2&#8242;-yl)methanone::US9896452, Ex. A199	Orexin receptor type 2	Homo sapiens		 2600							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373439	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373439&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727917	404342528							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741353	C[C@@H]1CCCN([C@@H]1CNc1ccc(nn1)C(F)(F)F)C(=O)c1cc(Cl)ccc1-c1ncccn1	InChI=1S/C23H22ClF3N6O/c1-14-4-2-11-33(18(14)13-30-20-8-7-19(31-32-20)23(25,26)27)22(34)17-12-15(24)5-6-16(17)21-28-9-3-10-29-21/h3,5-10,12,14,18H,2,4,11,13H2,1H3,(H,30,32)/t14-,18-/m1/s1	NGDJJCBHJUBRAH-RDTXWAMCSA-N	373440	(5-Chloro-2-(pyrimidin-2-yl)phenyl)((2S,3R)-3-methyl-2-(((6-(trifluoromethyl)pyridazin-3-yl)amino)methyl)piperidin-1-yl)methanone::US9896452, Ex. A200	Orexin/Hypocretin receptor type 1	Homo sapiens		 54.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373440	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373440&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728299	404342529							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741354	C[C@@H]1CCCN([C@@H]1CNc1ccc(nn1)C(F)(F)F)C(=O)c1cc(Cl)ccc1-c1ncccn1	InChI=1S/C23H22ClF3N6O/c1-14-4-2-11-33(18(14)13-30-20-8-7-19(31-32-20)23(25,26)27)22(34)17-12-15(24)5-6-16(17)21-28-9-3-10-29-21/h3,5-10,12,14,18H,2,4,11,13H2,1H3,(H,30,32)/t14-,18-/m1/s1	NGDJJCBHJUBRAH-RDTXWAMCSA-N	373440	(5-Chloro-2-(pyrimidin-2-yl)phenyl)((2S,3R)-3-methyl-2-(((6-(trifluoromethyl)pyridazin-3-yl)amino)methyl)piperidin-1-yl)methanone::US9896452, Ex. A200	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373440	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373440&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117728299	404342529							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741355	C[C@@H]1CCCN([C@@H]1CNc1ncc(cn1)C(F)(F)F)C(=O)c1cc(Cl)ccc1-c1ncccn1	InChI=1S/C23H22ClF3N6O/c1-14-4-2-9-33(19(14)13-32-22-30-11-15(12-31-22)23(25,26)27)21(34)18-10-16(24)5-6-17(18)20-28-7-3-8-29-20/h3,5-8,10-12,14,19H,2,4,9,13H2,1H3,(H,30,31,32)/t14-,19-/m1/s1	XDBPBLRBJQELMH-AUUYWEPGSA-N	373441	(5-Chloro-2-(pyrimidin-2-yl)phenyl)((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidin-1-yl)methanone::US9896452, Ex. A201	Orexin/Hypocretin receptor type 1	Homo sapiens		 4.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373441	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373441&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728231	404342530							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741356	C[C@@H]1CCCN([C@@H]1CNc1ncc(cn1)C(F)(F)F)C(=O)c1cc(Cl)ccc1-c1ncccn1	InChI=1S/C23H22ClF3N6O/c1-14-4-2-9-33(19(14)13-32-22-30-11-15(12-31-22)23(25,26)27)21(34)18-10-16(24)5-6-17(18)20-28-7-3-8-29-20/h3,5-8,10-12,14,19H,2,4,9,13H2,1H3,(H,30,31,32)/t14-,19-/m1/s1	XDBPBLRBJQELMH-AUUYWEPGSA-N	373441	(5-Chloro-2-(pyrimidin-2-yl)phenyl)((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidin-1-yl)methanone::US9896452, Ex. A201	Orexin receptor type 2	Homo sapiens		 2800							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373441	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373441&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117728231	404342530							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741357	C[C@@H]1CCCN([C@@H]1CNc1ncc(Cl)cn1)C(=O)c1cc(Cl)ccc1-c1ncccn1	InChI=1S/C22H22Cl2N6O/c1-14-4-2-9-30(19(14)13-29-22-27-11-16(24)12-28-22)21(31)18-10-15(23)5-6-17(18)20-25-7-3-8-26-20/h3,5-8,10-12,14,19H,2,4,9,13H2,1H3,(H,27,28,29)/t14-,19-/m1/s1	YHWJWGGNLJCUJI-AUUYWEPGSA-N	373442	(5-Chloro-2-(pyrimidin-2-yl)phenyl)((2S,3R)-2-(((5-chloropyrimidin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)methanone::US9896452, Ex. A202	Orexin/Hypocretin receptor type 1	Homo sapiens		 18.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373442	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373442&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727974	404342531							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741358	C[C@@H]1CCCN([C@@H]1CNc1ncc(Cl)cn1)C(=O)c1cc(Cl)ccc1-c1ncccn1	InChI=1S/C22H22Cl2N6O/c1-14-4-2-9-30(19(14)13-29-22-27-11-16(24)12-28-22)21(31)18-10-15(23)5-6-17(18)20-25-7-3-8-26-20/h3,5-8,10-12,14,19H,2,4,9,13H2,1H3,(H,27,28,29)/t14-,19-/m1/s1	YHWJWGGNLJCUJI-AUUYWEPGSA-N	373442	(5-Chloro-2-(pyrimidin-2-yl)phenyl)((2S,3R)-2-(((5-chloropyrimidin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)methanone::US9896452, Ex. A202	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373442	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373442&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727974	404342531							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741359	C[C@@H]1CCCN([C@@H]1CNc1ccc(Cl)cn1)C(=O)c1cc(Cl)ccc1-c1ncccn1	InChI=1S/C23H23Cl2N5O/c1-15-4-2-11-30(20(15)14-29-21-8-6-17(25)13-28-21)23(31)19-12-16(24)5-7-18(19)22-26-9-3-10-27-22/h3,5-10,12-13,15,20H,2,4,11,14H2,1H3,(H,28,29)/t15-,20-/m1/s1	RMOMVVZBRIYAIB-FOIQADDNSA-N	373443	(5-Chloro-2-(pyrimidin-2-yl)phenyl)((2S,3R)-2-(((5-chloropyridin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)methanone::US9896452, Ex. A203	Orexin/Hypocretin receptor type 1	Homo sapiens		 21.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373443	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373443&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728002	404342532							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741360	C[C@@H]1CCCN([C@@H]1CNc1ccc(Cl)cn1)C(=O)c1cc(Cl)ccc1-c1ncccn1	InChI=1S/C23H23Cl2N5O/c1-15-4-2-11-30(20(15)14-29-21-8-6-17(25)13-28-21)23(31)19-12-16(24)5-7-18(19)22-26-9-3-10-27-22/h3,5-10,12-13,15,20H,2,4,11,14H2,1H3,(H,28,29)/t15-,20-/m1/s1	RMOMVVZBRIYAIB-FOIQADDNSA-N	373443	(5-Chloro-2-(pyrimidin-2-yl)phenyl)((2S,3R)-2-(((5-chloropyridin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)methanone::US9896452, Ex. A203	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373443	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373443&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117728002	404342532							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741361	C[C@@H]1CCCN([C@@H]1CNc1nc2ccccc2o1)C(=O)c1cc(C)ccc1-c1ncccn1	InChI=1S/C26H27N5O2/c1-17-10-11-19(24-27-12-6-13-28-24)20(15-17)25(32)31-14-5-7-18(2)22(31)16-29-26-30-21-8-3-4-9-23(21)33-26/h3-4,6,8-13,15,18,22H,5,7,14,16H2,1-2H3,(H,29,30)/t18-,22-/m1/s1	CMHXDZPNJZYWHC-XMSQKQJNSA-N	373444	((2S,3R)-2-((Benzo[d]oxazol-2-ylamino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(pyrimidin-2-yl)phenyl)methanone::US9896452, Ex. A204	Orexin/Hypocretin receptor type 1	Homo sapiens		 3.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373444	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373444&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727950	404342533							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741362	C[C@@H]1CCCN([C@@H]1CNc1nc2ccccc2o1)C(=O)c1cc(C)ccc1-c1ncccn1	InChI=1S/C26H27N5O2/c1-17-10-11-19(24-27-12-6-13-28-24)20(15-17)25(32)31-14-5-7-18(2)22(31)16-29-26-30-21-8-3-4-9-23(21)33-26/h3-4,6,8-13,15,18,22H,5,7,14,16H2,1-2H3,(H,29,30)/t18-,22-/m1/s1	CMHXDZPNJZYWHC-XMSQKQJNSA-N	373444	((2S,3R)-2-((Benzo[d]oxazol-2-ylamino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(pyrimidin-2-yl)phenyl)methanone::US9896452, Ex. A204	Orexin receptor type 2	Homo sapiens		 260							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373444	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373444&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727950	404342533							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741363	C[C@@H]1CCCN([C@@H]1CNc1nc2cc(Cl)ccc2o1)C(=O)c1cc(C)ccc1-c1ncccn1	InChI=1S/C26H26ClN5O2/c1-16-6-8-19(24-28-10-4-11-29-24)20(13-16)25(33)32-12-3-5-17(2)22(32)15-30-26-31-21-14-18(27)7-9-23(21)34-26/h4,6-11,13-14,17,22H,3,5,12,15H2,1-2H3,(H,30,31)/t17-,22-/m1/s1	IFFBSTVOUUIZGY-VGOFRKELSA-N	373445	US9896452, Ex. A205	Orexin/Hypocretin receptor type 1	Homo sapiens		 11.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373445	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373445&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727846	404342534							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741364	C[C@@H]1CCCN([C@@H]1CNc1nc2cc(Cl)ccc2o1)C(=O)c1cc(C)ccc1-c1ncccn1	InChI=1S/C26H26ClN5O2/c1-16-6-8-19(24-28-10-4-11-29-24)20(13-16)25(33)32-12-3-5-17(2)22(32)15-30-26-31-21-14-18(27)7-9-23(21)34-26/h4,6-11,13-14,17,22H,3,5,12,15H2,1-2H3,(H,30,31)/t17-,22-/m1/s1	IFFBSTVOUUIZGY-VGOFRKELSA-N	373445	US9896452, Ex. A205	Orexin receptor type 2	Homo sapiens		 350							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373445	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373445&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727846	404342534							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741365	C[C@@H]1CCCN([C@@H]1CNc1nc2cc(F)ccc2o1)C(=O)c1cc(C)ccc1-c1ncccn1	InChI=1S/C26H26FN5O2/c1-16-6-8-19(24-28-10-4-11-29-24)20(13-16)25(33)32-12-3-5-17(2)22(32)15-30-26-31-21-14-18(27)7-9-23(21)34-26/h4,6-11,13-14,17,22H,3,5,12,15H2,1-2H3,(H,30,31)/t17-,22-/m1/s1	SVWKECQFVLIUDL-VGOFRKELSA-N	373446	((2S,3R)-2-(((5-Fluorobenzo[d]oxazol-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(pyrimidin-2-yl)phenyl)methanone::US9896452, Ex. A206	Orexin/Hypocretin receptor type 1	Homo sapiens		 6.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373446	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373446&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728249	404342535							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741366	C[C@@H]1CCCN([C@@H]1CNc1nc2cc(F)ccc2o1)C(=O)c1cc(C)ccc1-c1ncccn1	InChI=1S/C26H26FN5O2/c1-16-6-8-19(24-28-10-4-11-29-24)20(13-16)25(33)32-12-3-5-17(2)22(32)15-30-26-31-21-14-18(27)7-9-23(21)34-26/h4,6-11,13-14,17,22H,3,5,12,15H2,1-2H3,(H,30,31)/t17-,22-/m1/s1	SVWKECQFVLIUDL-VGOFRKELSA-N	373446	((2S,3R)-2-(((5-Fluorobenzo[d]oxazol-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-methyl-2-(pyrimidin-2-yl)phenyl)methanone::US9896452, Ex. A206	Orexin receptor type 2	Homo sapiens		 140							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373446	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373446&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117728249	404342535							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741367	C[C@@H]1CCCN([C@@H]1CNc1ncc(cn1)C(F)(F)F)C(=O)c1cc(F)ccc1-n1nccn1	InChI=1S/C21H21F4N7O/c1-13-3-2-8-31(18(13)12-28-20-26-10-14(11-27-20)21(23,24)25)19(33)16-9-15(22)4-5-17(16)32-29-6-7-30-32/h4-7,9-11,13,18H,2-3,8,12H2,1H3,(H,26,27,28)/t13-,18-/m1/s1	FHYUVPNQBPEQKT-FZKQIMNGSA-N	373447	(5-Fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidin-1-yl)methanone::US9896452, Ex. A207	Orexin/Hypocretin receptor type 1	Homo sapiens		 11.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373447	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373447&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727892	404342536							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741368	C[C@@H]1CCCN([C@@H]1CNc1ncc(cn1)C(F)(F)F)C(=O)c1cc(F)ccc1-n1nccn1	InChI=1S/C21H21F4N7O/c1-13-3-2-8-31(18(13)12-28-20-26-10-14(11-27-20)21(23,24)25)19(33)16-9-15(22)4-5-17(16)32-29-6-7-30-32/h4-7,9-11,13,18H,2-3,8,12H2,1H3,(H,26,27,28)/t13-,18-/m1/s1	FHYUVPNQBPEQKT-FZKQIMNGSA-N	373447	(5-Fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidin-1-yl)methanone::US9896452, Ex. A207	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373447	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373447&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727892	404342536							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741369	C[C@@H]1CCCN([C@@H]1CNc1ccc(nn1)C(F)(F)F)C(=O)c1cc(F)ccc1-n1nccn1	InChI=1S/C21H21F4N7O/c1-13-3-2-10-31(17(13)12-26-19-7-6-18(29-30-19)21(23,24)25)20(33)15-11-14(22)4-5-16(15)32-27-8-9-28-32/h4-9,11,13,17H,2-3,10,12H2,1H3,(H,26,30)/t13-,17-/m1/s1	DUEMGAZFOOAHKP-CXAGYDPISA-N	373448	(5-Fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)((2S,3R)-3-methyl-2-(((6-(trifluoromethyl)pyridazin-3-yl)amino)methyl)piperidin-1-yl)methanone::US9896452, Ex. A208	Orexin/Hypocretin receptor type 1	Homo sapiens		 200							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373448	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373448&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727838	404342537							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741370	C[C@@H]1CCCN([C@@H]1CNc1ccc(nn1)C(F)(F)F)C(=O)c1cc(F)ccc1-n1nccn1	InChI=1S/C21H21F4N7O/c1-13-3-2-10-31(17(13)12-26-19-7-6-18(29-30-19)21(23,24)25)20(33)15-11-14(22)4-5-16(15)32-27-8-9-28-32/h4-9,11,13,17H,2-3,10,12H2,1H3,(H,26,30)/t13-,17-/m1/s1	DUEMGAZFOOAHKP-CXAGYDPISA-N	373448	(5-Fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)((2S,3R)-3-methyl-2-(((6-(trifluoromethyl)pyridazin-3-yl)amino)methyl)piperidin-1-yl)methanone::US9896452, Ex. A208	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373448	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373448&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727838	404342537							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741371	C[C@@H]1CCCN([C@@H]1CNc1ccc(Cl)cn1)C(=O)c1cc(F)ccc1-n1nccn1	InChI=1S/C21H22ClFN6O/c1-14-3-2-10-28(19(14)13-25-20-7-4-15(22)12-24-20)21(30)17-11-16(23)5-6-18(17)29-26-8-9-27-29/h4-9,11-12,14,19H,2-3,10,13H2,1H3,(H,24,25)/t14-,19-/m1/s1	QHODWDZXMZACCH-AUUYWEPGSA-N	373449	((2S,3R)-2-(((5-Chloropyridin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A209	Orexin/Hypocretin receptor type 1	Homo sapiens		 45.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373449	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373449&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727620	404342538							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741372	C[C@@H]1CCCN([C@@H]1CNc1ccc(Cl)cn1)C(=O)c1cc(F)ccc1-n1nccn1	InChI=1S/C21H22ClFN6O/c1-14-3-2-10-28(19(14)13-25-20-7-4-15(22)12-24-20)21(30)17-11-16(23)5-6-18(17)29-26-8-9-27-29/h4-9,11-12,14,19H,2-3,10,13H2,1H3,(H,24,25)/t14-,19-/m1/s1	QHODWDZXMZACCH-AUUYWEPGSA-N	373449	((2S,3R)-2-(((5-Chloropyridin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A209	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373449	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373449&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727620	404342538							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741373	Cc1ccc(c(c1)C(=O)N1CCC(F)(F)C[C@H]1CNc1ccc(Cl)cn1)-n1nccn1	InChI=1S/C21H21ClF2N6O/c1-14-2-4-18(30-27-7-8-28-30)17(10-14)20(31)29-9-6-21(23,24)11-16(29)13-26-19-5-3-15(22)12-25-19/h2-5,7-8,10,12,16H,6,9,11,13H2,1H3,(H,25,26)/t16-/m0/s1	ZPQPWDHQHSWVPY-INIZCTEOSA-N	373450	(S)-(2-(((5-Chloropyridin-2-yl)amino)methyl)-4,4-difluoropiperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A210	Orexin/Hypocretin receptor type 1	Homo sapiens		 140							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373450	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373450&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727689	404342539							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741374	Cc1ccc(c(c1)C(=O)N1CCC(F)(F)C[C@H]1CNc1ccc(Cl)cn1)-n1nccn1	InChI=1S/C21H21ClF2N6O/c1-14-2-4-18(30-27-7-8-28-30)17(10-14)20(31)29-9-6-21(23,24)11-16(29)13-26-19-5-3-15(22)12-25-19/h2-5,7-8,10,12,16H,6,9,11,13H2,1H3,(H,25,26)/t16-/m0/s1	ZPQPWDHQHSWVPY-INIZCTEOSA-N	373450	(S)-(2-(((5-Chloropyridin-2-yl)amino)methyl)-4,4-difluoropiperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A210	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373450	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373450&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727689	404342539							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741375	Cc1ccc(c(c1)C(=O)N1CCC(F)(F)C[C@H]1CNc1ncc(cn1)C(F)(F)F)-n1nccn1	InChI=1S/C21H20F5N7O/c1-13-2-3-17(33-30-5-6-31-33)16(8-13)18(34)32-7-4-20(22,23)9-15(32)12-29-19-27-10-14(11-28-19)21(24,25)26/h2-3,5-6,8,10-11,15H,4,7,9,12H2,1H3,(H,27,28,29)/t15-/m0/s1	UBLDMODIJJPHMK-HNNXBMFYSA-N	373451	(S)-(4,4-Difluoro-2-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A211	Orexin/Hypocretin receptor type 1	Homo sapiens		 140							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373451	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373451&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727642	404342540							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741376	Cc1ccc(c(c1)C(=O)N1CCC(F)(F)C[C@H]1CNc1ncc(cn1)C(F)(F)F)-n1nccn1	InChI=1S/C21H20F5N7O/c1-13-2-3-17(33-30-5-6-31-33)16(8-13)18(34)32-7-4-20(22,23)9-15(32)12-29-19-27-10-14(11-28-19)21(24,25)26/h2-3,5-6,8,10-11,15H,4,7,9,12H2,1H3,(H,27,28,29)/t15-/m0/s1	UBLDMODIJJPHMK-HNNXBMFYSA-N	373451	(S)-(4,4-Difluoro-2-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A211	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373451	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373451&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727642	404342540							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741377	C[C@@H]1CCCN([C@@H]1CNc1ncc(cn1)C(F)(F)F)C(=O)c1cc(C)ccc1-c1ncccn1	InChI=1S/C24H25F3N6O/c1-15-6-7-18(21-28-8-4-9-29-21)19(11-15)22(34)33-10-3-5-16(2)20(33)14-32-23-30-12-17(13-31-23)24(25,26)27/h4,6-9,11-13,16,20H,3,5,10,14H2,1-2H3,(H,30,31,32)/t16-,20-/m1/s1	DESSTILEFOJHSP-OXQOHEQNSA-N	373452	((2S,3R)-3-Methyl-2-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(pyrimidin-2-yl)phenyl)methanone::US9896452, Ex. A212	Orexin/Hypocretin receptor type 1	Homo sapiens		 5.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373452	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373452&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728264	404342541							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741378	C[C@@H]1CCCN([C@@H]1CNc1ncc(cn1)C(F)(F)F)C(=O)c1cc(C)ccc1-c1ncccn1	InChI=1S/C24H25F3N6O/c1-15-6-7-18(21-28-8-4-9-29-21)19(11-15)22(34)33-10-3-5-16(2)20(33)14-32-23-30-12-17(13-31-23)24(25,26)27/h4,6-9,11-13,16,20H,3,5,10,14H2,1-2H3,(H,30,31,32)/t16-,20-/m1/s1	DESSTILEFOJHSP-OXQOHEQNSA-N	373452	((2S,3R)-3-Methyl-2-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(pyrimidin-2-yl)phenyl)methanone::US9896452, Ex. A212	Orexin receptor type 2	Homo sapiens		 3300							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373452	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373452&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117728264	404342541							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741379	C[C@@H]1CCCN([C@@H]1CNc1ncc2ccc(C)cc2n1)C(=O)c1cc(C)ccc1-n1nccn1	InChI=1S/C26H29N7O/c1-17-7-9-23(33-29-10-11-30-33)21(13-17)25(34)32-12-4-5-19(3)24(32)16-28-26-27-15-20-8-6-18(2)14-22(20)31-26/h6-11,13-15,19,24H,4-5,12,16H2,1-3H3,(H,27,28,31)/t19-,24-/m1/s1	QMUHINDYXGWPRL-NTKDMRAZSA-N	373453	((2S,3R)-3-Methyl-2-(((7-methylquinazolin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A215	Orexin/Hypocretin receptor type 1	Homo sapiens		 10.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373453	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373453&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727914	404342542							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741380	C[C@@H]1CCCN([C@@H]1CNc1ncc2ccc(C)cc2n1)C(=O)c1cc(C)ccc1-n1nccn1	InChI=1S/C26H29N7O/c1-17-7-9-23(33-29-10-11-30-33)21(13-17)25(34)32-12-4-5-19(3)24(32)16-28-26-27-15-20-8-6-18(2)14-22(20)31-26/h6-11,13-15,19,24H,4-5,12,16H2,1-3H3,(H,27,28,31)/t19-,24-/m1/s1	QMUHINDYXGWPRL-NTKDMRAZSA-N	373453	((2S,3R)-3-Methyl-2-(((7-methylquinazolin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A215	Orexin receptor type 2	Homo sapiens		 1300							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373453	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373453&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727914	404342542							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741381	C[C@@H]1CCCN([C@@H]1CNc1ncc2ccccc2n1)C(=O)c1cc(C)ccc1-n1nccn1	InChI=1S/C25H27N7O/c1-17-9-10-22(32-28-11-12-29-32)20(14-17)24(33)31-13-5-6-18(2)23(31)16-27-25-26-15-19-7-3-4-8-21(19)30-25/h3-4,7-12,14-15,18,23H,5-6,13,16H2,1-2H3,(H,26,27,30)/t18-,23-/m1/s1	RDGFBGVMGHBXGW-WZONZLPQSA-N	373454	((2S,3R)-3-Methyl-2-((quinazolin-2-ylamino)methyl)piperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A216	Orexin/Hypocretin receptor type 1	Homo sapiens		 5.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373454	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373454&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728268	404342543							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741382	C[C@@H]1CCCN([C@@H]1CNc1ncc2ccccc2n1)C(=O)c1cc(C)ccc1-n1nccn1	InChI=1S/C25H27N7O/c1-17-9-10-22(32-28-11-12-29-32)20(14-17)24(33)31-13-5-6-18(2)23(31)16-27-25-26-15-19-7-3-4-8-21(19)30-25/h3-4,7-12,14-15,18,23H,5-6,13,16H2,1-2H3,(H,26,27,30)/t18-,23-/m1/s1	RDGFBGVMGHBXGW-WZONZLPQSA-N	373454	((2S,3R)-3-Methyl-2-((quinazolin-2-ylamino)methyl)piperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A216	Orexin receptor type 2	Homo sapiens		 2000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373454	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373454&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117728268	404342543							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741383	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1nc(C)ccc1-c1ccccn1	InChI=1S/C25H26F3N5O/c1-16-6-5-13-33(21(16)15-31-22-11-9-18(14-30-22)25(26,27)28)24(34)23-19(10-8-17(2)32-23)20-7-3-4-12-29-20/h3-4,7-12,14,16,21H,5-6,13,15H2,1-2H3,(H,30,31)/t16-,21-/m1/s1	DLPSCLMVTPZXRV-IIBYNOLFSA-N	373455	((2S,3R)-3-Methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(6&#8242;-methyl-[2,3&#8242;-bipyridin]-2&#8242;-yl)methanone::US9896452, Ex. A217	Orexin/Hypocretin receptor type 1	Homo sapiens		 150							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373455	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373455&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728582	404342544							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741384	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1nc(C)ccc1-c1ccccn1	InChI=1S/C25H26F3N5O/c1-16-6-5-13-33(21(16)15-31-22-11-9-18(14-30-22)25(26,27)28)24(34)23-19(10-8-17(2)32-23)20-7-3-4-12-29-20/h3-4,7-12,14,16,21H,5-6,13,15H2,1-2H3,(H,30,31)/t16-,21-/m1/s1	DLPSCLMVTPZXRV-IIBYNOLFSA-N	373455	((2S,3R)-3-Methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(6&#8242;-methyl-[2,3&#8242;-bipyridin]-2&#8242;-yl)methanone::US9896452, Ex. A217	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373455	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373455&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117728582	404342544							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741385	C[C@@H]1CCCN([C@@H]1CNc1nc2ccccc2o1)C(=O)c1ccccc1-n1nccn1	InChI=1S/C23H24N6O2/c1-16-7-6-14-28(20(16)15-24-23-27-18-9-3-5-11-21(18)31-23)22(30)17-8-2-4-10-19(17)29-25-12-13-26-29/h2-5,8-13,16,20H,6-7,14-15H2,1H3,(H,24,27)/t16-,20-/m1/s1	OTQISTMACWUXOQ-OXQOHEQNSA-N	373456	(2-(2H-1,2,3-Triazol-2-yl)phenyl)((2S,3R)-2-((benzo[d]oxazol-2-ylamino)methyl)-3-methylpiperidin-1-yl)methanone::US9896452, Ex. A218	Orexin/Hypocretin receptor type 1	Homo sapiens		 130							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373456	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373456&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728328	404342545							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741386	C[C@@H]1CCCN([C@@H]1CNc1nc2ccccc2o1)C(=O)c1ccccc1-n1nccn1	InChI=1S/C23H24N6O2/c1-16-7-6-14-28(20(16)15-24-23-27-18-9-3-5-11-21(18)31-23)22(30)17-8-2-4-10-19(17)29-25-12-13-26-29/h2-5,8-13,16,20H,6-7,14-15H2,1H3,(H,24,27)/t16-,20-/m1/s1	OTQISTMACWUXOQ-OXQOHEQNSA-N	373456	(2-(2H-1,2,3-Triazol-2-yl)phenyl)((2S,3R)-2-((benzo[d]oxazol-2-ylamino)methyl)-3-methylpiperidin-1-yl)methanone::US9896452, Ex. A218	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373456	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373456&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117728328	404342545							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741387	C[C@@H]1CCCN([C@@H]1CNc1nc2cc(Cl)ccc2o1)C(=O)c1ccccc1-n1nccn1	InChI=1S/C23H23ClN6O2/c1-15-5-4-12-29(22(31)17-6-2-3-7-19(17)30-26-10-11-27-30)20(15)14-25-23-28-18-13-16(24)8-9-21(18)32-23/h2-3,6-11,13,15,20H,4-5,12,14H2,1H3,(H,25,28)/t15-,20-/m1/s1	FDRWAHVENDNMSA-FOIQADDNSA-N	373457	(2-(2H-1,2,3-Triazol-2-yl)phenyl)((2S,3R)-2-(((5-chlorobenzo[d]oxazol-2-yl)amino)methyl)-3-methylpiperidin-1-yl)methanone::US9896452, Ex. A219	Orexin/Hypocretin receptor type 1	Homo sapiens		 2600							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373457	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373457&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727666	404342546							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741388	C[C@@H]1CCCN([C@@H]1CNc1nc2cc(Cl)ccc2o1)C(=O)c1ccccc1-n1nccn1	InChI=1S/C23H23ClN6O2/c1-15-5-4-12-29(22(31)17-6-2-3-7-19(17)30-26-10-11-27-30)20(15)14-25-23-28-18-13-16(24)8-9-21(18)32-23/h2-3,6-11,13,15,20H,4-5,12,14H2,1H3,(H,25,28)/t15-,20-/m1/s1	FDRWAHVENDNMSA-FOIQADDNSA-N	373457	(2-(2H-1,2,3-Triazol-2-yl)phenyl)((2S,3R)-2-(((5-chlorobenzo[d]oxazol-2-yl)amino)methyl)-3-methylpiperidin-1-yl)methanone::US9896452, Ex. A219	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373457	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373457&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727666	404342546							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741389	C[C@@H]1CCCN([C@@H]1CNc1ncc2cc(C)ccc2n1)C(=O)c1cc(C)ccc1-n1nccn1	InChI=1S/C26H29N7O/c1-17-6-8-22-20(13-17)15-27-26(31-22)28-16-24-19(3)5-4-12-32(24)25(34)21-14-18(2)7-9-23(21)33-29-10-11-30-33/h6-11,13-15,19,24H,4-5,12,16H2,1-3H3,(H,27,28,31)/t19-,24-/m1/s1	SGVPKQADOWGHFJ-NTKDMRAZSA-N	373458	((2S,3R)-3-Methyl-2-(((6-methylquinazolin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A220	Orexin/Hypocretin receptor type 1	Homo sapiens		 11.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373458	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373458&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728103	404342547							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741390	C[C@@H]1CCCN([C@@H]1CNc1ncc2cc(C)ccc2n1)C(=O)c1cc(C)ccc1-n1nccn1	InChI=1S/C26H29N7O/c1-17-6-8-22-20(13-17)15-27-26(31-22)28-16-24-19(3)5-4-12-32(24)25(34)21-14-18(2)7-9-23(21)33-29-10-11-30-33/h6-11,13-15,19,24H,4-5,12,16H2,1-3H3,(H,27,28,31)/t19-,24-/m1/s1	SGVPKQADOWGHFJ-NTKDMRAZSA-N	373458	((2S,3R)-3-Methyl-2-(((6-methylquinazolin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A220	Orexin receptor type 2	Homo sapiens		 2500							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373458	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373458&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117728103	404342547							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741391	C[C@@H]1CCCN([C@@H]1CNc1ncc(Cl)cn1)C(=O)c1cc(F)ccc1-n1nccn1	InChI=1S/C20H21ClFN7O/c1-13-3-2-8-28(18(13)12-25-20-23-10-14(21)11-24-20)19(30)16-9-15(22)4-5-17(16)29-26-6-7-27-29/h4-7,9-11,13,18H,2-3,8,12H2,1H3,(H,23,24,25)/t13-,18-/m1/s1	WKJZUFUODZRBPZ-FZKQIMNGSA-N	373459	((2S,3R)-2-(((5-Chloropyrimidin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A221	Orexin/Hypocretin receptor type 1	Homo sapiens		 32.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373459	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373459&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727982	404342548							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741392	C[C@@H]1CCCN([C@@H]1CNc1ncc(Cl)cn1)C(=O)c1cc(F)ccc1-n1nccn1	InChI=1S/C20H21ClFN7O/c1-13-3-2-8-28(18(13)12-25-20-23-10-14(21)11-24-20)19(30)16-9-15(22)4-5-17(16)29-26-6-7-27-29/h4-7,9-11,13,18H,2-3,8,12H2,1H3,(H,23,24,25)/t13-,18-/m1/s1	WKJZUFUODZRBPZ-FZKQIMNGSA-N	373459	((2S,3R)-2-(((5-Chloropyrimidin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A221	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373459	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373459&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727982	404342548							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741393	C[C@@H]1CCCN([C@@H]1CNc1ncc(Cl)cn1)C(=O)c1nc(C)ccc1-c1cccnc1	InChI=1S/C23H25ClN6O/c1-15-5-4-10-30(20(15)14-28-23-26-12-18(24)13-27-23)22(31)21-19(8-7-16(2)29-21)17-6-3-9-25-11-17/h3,6-9,11-13,15,20H,4-5,10,14H2,1-2H3,(H,26,27,28)/t15-,20-/m1/s1	UNPHEIGOIBVSIF-FOIQADDNSA-N	373460	((2S,3R)-2-(((5-Chloropyrimidin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(6-methyl-[3,3&#8242;-bipyridin]-2-yl)methanone::US9896452, Ex. A222	Orexin/Hypocretin receptor type 1	Homo sapiens		 82.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373460	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373460&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728669	404342549							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741394	C[C@@H]1CCCN([C@@H]1CNc1ncc(Cl)cn1)C(=O)c1nc(C)ccc1-c1cccnc1	InChI=1S/C23H25ClN6O/c1-15-5-4-10-30(20(15)14-28-23-26-12-18(24)13-27-23)22(31)21-19(8-7-16(2)29-21)17-6-3-9-25-11-17/h3,6-9,11-13,15,20H,4-5,10,14H2,1-2H3,(H,26,27,28)/t15-,20-/m1/s1	UNPHEIGOIBVSIF-FOIQADDNSA-N	373460	((2S,3R)-2-(((5-Chloropyrimidin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(6-methyl-[3,3&#8242;-bipyridin]-2-yl)methanone::US9896452, Ex. A222	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373460	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373460&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117728669	404342549							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741395	C[C@@H]1CCCN([C@@H]1CNc1ncc(cn1)C(F)(F)F)C(=O)c1nc(C)ccc1-c1cccnc1	InChI=1S/C24H25F3N6O/c1-15-5-4-10-33(20(15)14-31-23-29-12-18(13-30-23)24(25,26)27)22(34)21-19(8-7-16(2)32-21)17-6-3-9-28-11-17/h3,6-9,11-13,15,20H,4-5,10,14H2,1-2H3,(H,29,30,31)/t15-,20-/m1/s1	PUHWKALPFTWQID-FOIQADDNSA-N	373461	((2S,3R)-3-Methyl-2-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidin-1-yl)(6-methyl-[3,3&#8242;-bipyridin]-2-yl)methanone::US9896452, Ex. A223	Orexin/Hypocretin receptor type 1	Homo sapiens		 37.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373461	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373461&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727839	404342550							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741396	C[C@@H]1CCCN([C@@H]1CNc1ncc(cn1)C(F)(F)F)C(=O)c1nc(C)ccc1-c1cccnc1	InChI=1S/C24H25F3N6O/c1-15-5-4-10-33(20(15)14-31-23-29-12-18(13-30-23)24(25,26)27)22(34)21-19(8-7-16(2)32-21)17-6-3-9-28-11-17/h3,6-9,11-13,15,20H,4-5,10,14H2,1-2H3,(H,29,30,31)/t15-,20-/m1/s1	PUHWKALPFTWQID-FOIQADDNSA-N	373461	((2S,3R)-3-Methyl-2-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidin-1-yl)(6-methyl-[3,3&#8242;-bipyridin]-2-yl)methanone::US9896452, Ex. A223	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373461	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373461&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727839	404342550							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741397	C[C@@H]1CCCN([C@@H]1CNc1ccc(Cl)cn1)C(=O)c1nc(C)ccc1-c1cccnc1	InChI=1S/C24H26ClN5O/c1-16-5-4-12-30(21(16)15-28-22-10-8-19(25)14-27-22)24(31)23-20(9-7-17(2)29-23)18-6-3-11-26-13-18/h3,6-11,13-14,16,21H,4-5,12,15H2,1-2H3,(H,27,28)/t16-,21-/m1/s1	XUNFIPFXMFJLQJ-IIBYNOLFSA-N	373462	((2S,3R)-2-(((5-Chloropyridin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(6-methyl-[3,3&#8242;-bipyridin]-2-yl)methanone::US9896452, Ex. A224	Orexin/Hypocretin receptor type 1	Homo sapiens		 13.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373462	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373462&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728770	404342551							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741398	C[C@@H]1CCCN([C@@H]1CNc1ccc(Cl)cn1)C(=O)c1nc(C)ccc1-c1cccnc1	InChI=1S/C24H26ClN5O/c1-16-5-4-12-30(21(16)15-28-22-10-8-19(25)14-27-22)24(31)23-20(9-7-17(2)29-23)18-6-3-11-26-13-18/h3,6-11,13-14,16,21H,4-5,12,15H2,1-2H3,(H,27,28)/t16-,21-/m1/s1	XUNFIPFXMFJLQJ-IIBYNOLFSA-N	373462	((2S,3R)-2-(((5-Chloropyridin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(6-methyl-[3,3&#8242;-bipyridin]-2-yl)methanone::US9896452, Ex. A224	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373462	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373462&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117728770	404342551							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741399	C[C@@H]1CCCN([C@@H]1CNc1ncc(Cl)cn1)C(=O)c1nccc2ccccc12	InChI=1S/C21H22ClN5O/c1-14-5-4-10-27(18(14)13-26-21-24-11-16(22)12-25-21)20(28)19-17-7-3-2-6-15(17)8-9-23-19/h2-3,6-9,11-12,14,18H,4-5,10,13H2,1H3,(H,24,25,26)/t14-,18-/m1/s1	GNJMUDFHEQZVKO-RDTXWAMCSA-N	373463	((2S,3R)-2-(((5-Chloropyrimidin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(isoquinolin-1-yl)methanone::US9896452, Ex. A225	Orexin/Hypocretin receptor type 1	Homo sapiens		 340							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373463	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373463&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727732	404342552							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741400	C[C@@H]1CCCN([C@@H]1CNc1ncc(Cl)cn1)C(=O)c1nccc2ccccc12	InChI=1S/C21H22ClN5O/c1-14-5-4-10-27(18(14)13-26-21-24-11-16(22)12-25-21)20(28)19-17-7-3-2-6-15(17)8-9-23-19/h2-3,6-9,11-12,14,18H,4-5,10,13H2,1H3,(H,24,25,26)/t14-,18-/m1/s1	GNJMUDFHEQZVKO-RDTXWAMCSA-N	373463	((2S,3R)-2-(((5-Chloropyrimidin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(isoquinolin-1-yl)methanone::US9896452, Ex. A225	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373463	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373463&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727732	404342552							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741401	C[C@@H]1CCCN([C@@H]1CNc1ncc(Cl)cn1)C(=O)c1cc(F)ccc1-c1ncccn1	InChI=1S/C22H22ClFN6O/c1-14-4-2-9-30(19(14)13-29-22-27-11-15(23)12-28-22)21(31)18-10-16(24)5-6-17(18)20-25-7-3-8-26-20/h3,5-8,10-12,14,19H,2,4,9,13H2,1H3,(H,27,28,29)/t14-,19-/m1/s1	CTZGAXJGPLLTHJ-AUUYWEPGSA-N	373464	((2S,3R)-2-(((5-Chloropyrimidin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-fluoro-2-(pyrimidin-2-yl)phenyl)methanone::US9896452, Ex. A226	Orexin/Hypocretin receptor type 1	Homo sapiens		 11.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373464	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373464&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728234	404342553							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741402	C[C@@H]1CCCN([C@@H]1CNc1ncc(Cl)cn1)C(=O)c1cc(F)ccc1-c1ncccn1	InChI=1S/C22H22ClFN6O/c1-14-4-2-9-30(19(14)13-29-22-27-11-15(23)12-28-22)21(31)18-10-16(24)5-6-17(18)20-25-7-3-8-26-20/h3,5-8,10-12,14,19H,2,4,9,13H2,1H3,(H,27,28,29)/t14-,19-/m1/s1	CTZGAXJGPLLTHJ-AUUYWEPGSA-N	373464	((2S,3R)-2-(((5-Chloropyrimidin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-fluoro-2-(pyrimidin-2-yl)phenyl)methanone::US9896452, Ex. A226	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373464	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373464&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117728234	404342553							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741403	C[C@@H]1CCCN([C@@H]1CNc1ncc(cn1)C(F)(F)F)C(=O)c1cc(F)ccc1-c1ncccn1	InChI=1S/C23H22F4N6O/c1-14-4-2-9-33(19(14)13-32-22-30-11-15(12-31-22)23(25,26)27)21(34)18-10-16(24)5-6-17(18)20-28-7-3-8-29-20/h3,5-8,10-12,14,19H,2,4,9,13H2,1H3,(H,30,31,32)/t14-,19-/m1/s1	SCESJOPTFMLSAI-AUUYWEPGSA-N	373465	(5-Fluoro-2-(pyrimidin-2-yl)phenyl)((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidin-1-yl)methanone::US9896452, Ex. A227	Orexin/Hypocretin receptor type 1	Homo sapiens		 2.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373465	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373465&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727996	404342554							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741404	C[C@@H]1CCCN([C@@H]1CNc1ncc(cn1)C(F)(F)F)C(=O)c1cc(F)ccc1-c1ncccn1	InChI=1S/C23H22F4N6O/c1-14-4-2-9-33(19(14)13-32-22-30-11-15(12-31-22)23(25,26)27)21(34)18-10-16(24)5-6-17(18)20-28-7-3-8-29-20/h3,5-8,10-12,14,19H,2,4,9,13H2,1H3,(H,30,31,32)/t14-,19-/m1/s1	SCESJOPTFMLSAI-AUUYWEPGSA-N	373465	(5-Fluoro-2-(pyrimidin-2-yl)phenyl)((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidin-1-yl)methanone::US9896452, Ex. A227	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373465	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373465&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727996	404342554							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741405	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1cc(F)ccc1-c1ncccn1	InChI=1S/C24H23F4N5O/c1-15-4-2-11-33(20(15)14-32-21-8-5-16(13-31-21)24(26,27)28)23(34)19-12-17(25)6-7-18(19)22-29-9-3-10-30-22/h3,5-10,12-13,15,20H,2,4,11,14H2,1H3,(H,31,32)/t15-,20-/m1/s1	YWQIKKGXOBNSIM-FOIQADDNSA-N	373466	(5-Fluoro-2-(pyrimidin-2-yl)phenyl)((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)methanone::US9896452, Ex. A228	Orexin/Hypocretin receptor type 1	Homo sapiens		 1.000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373466	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373466&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728022	404342555							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741406	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1cc(F)ccc1-c1ncccn1	InChI=1S/C24H23F4N5O/c1-15-4-2-11-33(20(15)14-32-21-8-5-16(13-31-21)24(26,27)28)23(34)19-12-17(25)6-7-18(19)22-29-9-3-10-30-22/h3,5-10,12-13,15,20H,2,4,11,14H2,1H3,(H,31,32)/t15-,20-/m1/s1	YWQIKKGXOBNSIM-FOIQADDNSA-N	373466	(5-Fluoro-2-(pyrimidin-2-yl)phenyl)((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)methanone::US9896452, Ex. A228	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373466	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373466&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117728022	404342555							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741407	C[C@@H]1CCCN([C@@H]1CNc1ccc(Cl)cn1)C(=O)c1cc(F)ccc1-c1ncccn1	InChI=1S/C23H23ClFN5O/c1-15-4-2-11-30(20(15)14-29-21-8-5-16(24)13-28-21)23(31)19-12-17(25)6-7-18(19)22-26-9-3-10-27-22/h3,5-10,12-13,15,20H,2,4,11,14H2,1H3,(H,28,29)/t15-,20-/m1/s1	GDIBHJFPOZOJID-FOIQADDNSA-N	373467	((2S,3R)-2-(((5-Chloropyridin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-fluoro-2-(pyrimidin-2-yl)phenyl)methanone::US9896452, Ex. A229	Orexin/Hypocretin receptor type 1	Homo sapiens		 4.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373467	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373467&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727935	404342556							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741408	C[C@@H]1CCCN([C@@H]1CNc1ccc(Cl)cn1)C(=O)c1cc(F)ccc1-c1ncccn1	InChI=1S/C23H23ClFN5O/c1-15-4-2-11-30(20(15)14-29-21-8-5-16(24)13-28-21)23(31)19-12-17(25)6-7-18(19)22-26-9-3-10-27-22/h3,5-10,12-13,15,20H,2,4,11,14H2,1H3,(H,28,29)/t15-,20-/m1/s1	GDIBHJFPOZOJID-FOIQADDNSA-N	373467	((2S,3R)-2-(((5-Chloropyridin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(5-fluoro-2-(pyrimidin-2-yl)phenyl)methanone::US9896452, Ex. A229	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373467	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373467&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727935	404342556							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741409	C[C@@H]1CCCN([C@@H]1CNc1ncc(cn1)C(F)(F)F)C(=O)c1cccc(F)c1-c1ncccn1	InChI=1S/C23H22F4N6O/c1-14-5-3-10-33(18(14)13-32-22-30-11-15(12-31-22)23(25,26)27)21(34)16-6-2-7-17(24)19(16)20-28-8-4-9-29-20/h2,4,6-9,11-12,14,18H,3,5,10,13H2,1H3,(H,30,31,32)/t14-,18-/m1/s1	WYGURLLNVZJXDA-RDTXWAMCSA-N	373468	(3-Fluoro-2-(pyrimidin-2-yl)phenyl)((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidin-1-yl)methanone::US9896452, Ex. A230	Orexin/Hypocretin receptor type 1	Homo sapiens		 5.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373468	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373468&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728101	404342557							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741410	C[C@@H]1CCCN([C@@H]1CNc1ncc(cn1)C(F)(F)F)C(=O)c1cccc(F)c1-c1ncccn1	InChI=1S/C23H22F4N6O/c1-14-5-3-10-33(18(14)13-32-22-30-11-15(12-31-22)23(25,26)27)21(34)16-6-2-7-17(24)19(16)20-28-8-4-9-29-20/h2,4,6-9,11-12,14,18H,3,5,10,13H2,1H3,(H,30,31,32)/t14-,18-/m1/s1	WYGURLLNVZJXDA-RDTXWAMCSA-N	373468	(3-Fluoro-2-(pyrimidin-2-yl)phenyl)((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidin-1-yl)methanone::US9896452, Ex. A230	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373468	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373468&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117728101	404342557							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741411	C[C@@H]1CCCN([C@@H]1CNc1ncc(Cl)cn1)C(=O)c1cccc(F)c1-c1ncccn1	InChI=1S/C22H22ClFN6O/c1-14-5-3-10-30(18(14)13-29-22-27-11-15(23)12-28-22)21(31)16-6-2-7-17(24)19(16)20-25-8-4-9-26-20/h2,4,6-9,11-12,14,18H,3,5,10,13H2,1H3,(H,27,28,29)/t14-,18-/m1/s1	MQZYQMQHJPVUSJ-RDTXWAMCSA-N	373469	(3-Fluoro-2-(pyrimidin-2-yl)phenyl)((2S,3R)-3-methyl-2-(((5-chloropyrimidin-2-yl)amino)methyl)piperidin-1-yl)methanone::US9896452, Ex. A231	Orexin/Hypocretin receptor type 1	Homo sapiens		 17.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373469	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373469&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728044	404342558							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741412	C[C@@H]1CCCN([C@@H]1CNc1ncc(Cl)cn1)C(=O)c1cccc(F)c1-c1ncccn1	InChI=1S/C22H22ClFN6O/c1-14-5-3-10-30(18(14)13-29-22-27-11-15(23)12-28-22)21(31)16-6-2-7-17(24)19(16)20-25-8-4-9-26-20/h2,4,6-9,11-12,14,18H,3,5,10,13H2,1H3,(H,27,28,29)/t14-,18-/m1/s1	MQZYQMQHJPVUSJ-RDTXWAMCSA-N	373469	(3-Fluoro-2-(pyrimidin-2-yl)phenyl)((2S,3R)-3-methyl-2-(((5-chloropyrimidin-2-yl)amino)methyl)piperidin-1-yl)methanone::US9896452, Ex. A231	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373469	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373469&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117728044	404342558							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741413	C[C@@H]1CCCN([C@@H]1CNc1ccc(Cl)cn1)C(=O)c1cccc(F)c1-c1ncccn1	InChI=1S/C23H23ClFN5O/c1-15-5-3-12-30(19(15)14-29-20-9-8-16(24)13-28-20)23(31)17-6-2-7-18(25)21(17)22-26-10-4-11-27-22/h2,4,6-11,13,15,19H,3,5,12,14H2,1H3,(H,28,29)/t15-,19-/m1/s1	ISXXZLNGFZBNDF-DNVCBOLYSA-N	373470	((2S,3R)-2-(((5-chloropyridin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(3-fluoro-2-(pyrimidin-2-yl)phenyl)methanone::US9896452, Ex. A232	Orexin/Hypocretin receptor type 1	Homo sapiens		 8.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373470	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373470&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728193	404342559							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741414	C[C@@H]1CCCN([C@@H]1CNc1ccc(Cl)cn1)C(=O)c1cccc(F)c1-c1ncccn1	InChI=1S/C23H23ClFN5O/c1-15-5-3-12-30(19(15)14-29-20-9-8-16(24)13-28-20)23(31)17-6-2-7-18(25)21(17)22-26-10-4-11-27-22/h2,4,6-11,13,15,19H,3,5,12,14H2,1H3,(H,28,29)/t15-,19-/m1/s1	ISXXZLNGFZBNDF-DNVCBOLYSA-N	373470	((2S,3R)-2-(((5-chloropyridin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(3-fluoro-2-(pyrimidin-2-yl)phenyl)methanone::US9896452, Ex. A232	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373470	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373470&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117728193	404342559							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741415	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1cccc(F)c1-c1ncccn1	InChI=1S/C24H23F4N5O/c1-15-5-3-12-33(19(15)14-32-20-9-8-16(13-31-20)24(26,27)28)23(34)17-6-2-7-18(25)21(17)22-29-10-4-11-30-22/h2,4,6-11,13,15,19H,3,5,12,14H2,1H3,(H,31,32)/t15-,19-/m1/s1	RYLOAVVOYUGPSB-DNVCBOLYSA-N	373471	(3-Fluoro-2-(pyrimidin-2-yl)phenyl)((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)methanone::US9896452, Ex. A233	Orexin/Hypocretin receptor type 1	Homo sapiens		 5.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373471	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373471&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727754	404342560							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741416	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1cccc(F)c1-c1ncccn1	InChI=1S/C24H23F4N5O/c1-15-5-3-12-33(19(15)14-32-20-9-8-16(13-31-20)24(26,27)28)23(34)17-6-2-7-18(25)21(17)22-29-10-4-11-30-22/h2,4,6-11,13,15,19H,3,5,12,14H2,1H3,(H,31,32)/t15-,19-/m1/s1	RYLOAVVOYUGPSB-DNVCBOLYSA-N	373471	(3-Fluoro-2-(pyrimidin-2-yl)phenyl)((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)methanone::US9896452, Ex. A233	Orexin receptor type 2	Homo sapiens		 810							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373471	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373471&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727754	404342560							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741417	C[C@@H]1CCCN([C@@H]1CNc1ncc(Cl)cn1)C(=O)c1c(F)cccc1-c1ncccn1	InChI=1S/C22H22ClFN6O/c1-14-5-3-10-30(18(14)13-29-22-27-11-15(23)12-28-22)21(31)19-16(6-2-7-17(19)24)20-25-8-4-9-26-20/h2,4,6-9,11-12,14,18H,3,5,10,13H2,1H3,(H,27,28,29)/t14-,18-/m1/s1	FMSAOPOHKGHUSJ-RDTXWAMCSA-N	373472	((2S,3R)-2-(((5-chloropyrimidin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(2-fluoro-6-(pyrimidin-2-yl)phenyl)methanone::US9896452, Ex. A239	Orexin/Hypocretin receptor type 1	Homo sapiens		 83.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373472	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373472&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728337	404342561							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741418	C[C@@H]1CCCN([C@@H]1CNc1ncc(Cl)cn1)C(=O)c1c(F)cccc1-c1ncccn1	InChI=1S/C22H22ClFN6O/c1-14-5-3-10-30(18(14)13-29-22-27-11-15(23)12-28-22)21(31)19-16(6-2-7-17(19)24)20-25-8-4-9-26-20/h2,4,6-9,11-12,14,18H,3,5,10,13H2,1H3,(H,27,28,29)/t14-,18-/m1/s1	FMSAOPOHKGHUSJ-RDTXWAMCSA-N	373472	((2S,3R)-2-(((5-chloropyrimidin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(2-fluoro-6-(pyrimidin-2-yl)phenyl)methanone::US9896452, Ex. A239	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373472	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373472&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117728337	404342561							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741419	C[C@@H]1CCCN([C@@H]1CNc1ncc(cn1)C(F)(F)F)C(=O)c1c(F)cccc1-c1ncccn1	InChI=1S/C23H22F4N6O/c1-14-5-3-10-33(18(14)13-32-22-30-11-15(12-31-22)23(25,26)27)21(34)19-16(6-2-7-17(19)24)20-28-8-4-9-29-20/h2,4,6-9,11-12,14,18H,3,5,10,13H2,1H3,(H,30,31,32)/t14-,18-/m1/s1	SUORDRLKFSHXJA-RDTXWAMCSA-N	373473	(2-Fluoro-6-(pyrimidin-2-yl)phenyl)((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidin-1-yl)methanone::US9896452, Ex. A240	Orexin/Hypocretin receptor type 1	Homo sapiens		 3.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373473	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373473&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727828	404342562							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741420	C[C@@H]1CCCN([C@@H]1CNc1ncc(cn1)C(F)(F)F)C(=O)c1c(F)cccc1-c1ncccn1	InChI=1S/C23H22F4N6O/c1-14-5-3-10-33(18(14)13-32-22-30-11-15(12-31-22)23(25,26)27)21(34)19-16(6-2-7-17(19)24)20-28-8-4-9-29-20/h2,4,6-9,11-12,14,18H,3,5,10,13H2,1H3,(H,30,31,32)/t14-,18-/m1/s1	SUORDRLKFSHXJA-RDTXWAMCSA-N	373473	(2-Fluoro-6-(pyrimidin-2-yl)phenyl)((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidin-1-yl)methanone::US9896452, Ex. A240	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373473	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373473&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727828	404342562							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741421	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1c(F)cccc1-c1ncccn1	InChI=1S/C24H23F4N5O/c1-15-5-3-12-33(19(15)14-32-20-9-8-16(13-31-20)24(26,27)28)23(34)21-17(6-2-7-18(21)25)22-29-10-4-11-30-22/h2,4,6-11,13,15,19H,3,5,12,14H2,1H3,(H,31,32)/t15-,19-/m1/s1	FOEUTAWOTAPZPU-DNVCBOLYSA-N	373474	(2-Fluoro-6-(pyrimidin-2-yl)phenyl)((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)methanone::US9896452, Ex. A241	Orexin/Hypocretin receptor type 1	Homo sapiens		 9.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373474	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373474&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727852	404342563							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741422	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1c(F)cccc1-c1ncccn1	InChI=1S/C24H23F4N5O/c1-15-5-3-12-33(19(15)14-32-20-9-8-16(13-31-20)24(26,27)28)23(34)21-17(6-2-7-18(21)25)22-29-10-4-11-30-22/h2,4,6-11,13,15,19H,3,5,12,14H2,1H3,(H,31,32)/t15-,19-/m1/s1	FOEUTAWOTAPZPU-DNVCBOLYSA-N	373474	(2-Fluoro-6-(pyrimidin-2-yl)phenyl)((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)methanone::US9896452, Ex. A241	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373474	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373474&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727852	404342563							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741423	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1cc(F)c(F)cc1-c1ncccn1	InChI=1S/C24H22F5N5O/c1-14-4-2-9-34(20(14)13-33-21-6-5-15(12-32-21)24(27,28)29)23(35)17-11-19(26)18(25)10-16(17)22-30-7-3-8-31-22/h3,5-8,10-12,14,20H,2,4,9,13H2,1H3,(H,32,33)/t14-,20-/m1/s1	HESYYKSASFCJTJ-JLTOFOAXSA-N	373475	(4,5-difluoro-2-(pyrimidin-2-yl)phenyl)((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)methanone::US9896452, Ex. A242	Orexin/Hypocretin receptor type 1	Homo sapiens		 24.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373475	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373475&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727639	404342564							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741424	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1cc(F)c(F)cc1-c1ncccn1	InChI=1S/C24H22F5N5O/c1-14-4-2-9-34(20(14)13-33-21-6-5-15(12-32-21)24(27,28)29)23(35)17-11-19(26)18(25)10-16(17)22-30-7-3-8-31-22/h3,5-8,10-12,14,20H,2,4,9,13H2,1H3,(H,32,33)/t14-,20-/m1/s1	HESYYKSASFCJTJ-JLTOFOAXSA-N	373475	(4,5-difluoro-2-(pyrimidin-2-yl)phenyl)((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)methanone::US9896452, Ex. A242	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373475	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373475&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727639	404342564							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741425	C[C@@H]1CCCN([C@@H]1CNc1ncc(cn1)C(F)(F)F)C(=O)c1cc(F)c(F)cc1-c1ncccn1	InChI=1S/C23H21F5N6O/c1-13-4-2-7-34(19(13)12-33-22-31-10-14(11-32-22)23(26,27)28)21(35)16-9-18(25)17(24)8-15(16)20-29-5-3-6-30-20/h3,5-6,8-11,13,19H,2,4,7,12H2,1H3,(H,31,32,33)/t13-,19-/m1/s1	GVXZUOBZCHXFNF-BFUOFWGJSA-N	373476	(4,5-difluoro-2-(pyrimidin-2-yl)phenyl)((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidin-1-yl)methanone::US9896452, Ex. A243	Orexin/Hypocretin receptor type 1	Homo sapiens		 75.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373476	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373476&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728335	404342565							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741426	C[C@@H]1CCCN([C@@H]1CNc1ncc(cn1)C(F)(F)F)C(=O)c1cc(F)c(F)cc1-c1ncccn1	InChI=1S/C23H21F5N6O/c1-13-4-2-7-34(19(13)12-33-22-31-10-14(11-32-22)23(26,27)28)21(35)16-9-18(25)17(24)8-15(16)20-29-5-3-6-30-20/h3,5-6,8-11,13,19H,2,4,7,12H2,1H3,(H,31,32,33)/t13-,19-/m1/s1	GVXZUOBZCHXFNF-BFUOFWGJSA-N	373476	(4,5-difluoro-2-(pyrimidin-2-yl)phenyl)((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidin-1-yl)methanone::US9896452, Ex. A243	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373476	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373476&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117728335	404342565							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741427	C[C@@H]1CCCN([C@@H]1CNc1ncc(Cl)cn1)C(=O)c1cc(F)c(F)cc1-c1ncccn1	InChI=1S/C22H21ClF2N6O/c1-13-4-2-7-31(19(13)12-30-22-28-10-14(23)11-29-22)21(32)16-9-18(25)17(24)8-15(16)20-26-5-3-6-27-20/h3,5-6,8-11,13,19H,2,4,7,12H2,1H3,(H,28,29,30)/t13-,19-/m1/s1	SBTWFFJFXDIIKU-BFUOFWGJSA-N	373477	((2S,3R)-2-(((5-chloropyrimidin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(4,5-difluoro-2-(pyrimidin-2-yl)phenyl)methanone::US9896452, Ex. A244	Orexin/Hypocretin receptor type 1	Homo sapiens		 1300							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373477	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373477&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117729441	404342566							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741428	C[C@@H]1CCCN([C@@H]1CNc1ncc(Cl)cn1)C(=O)c1cc(F)c(F)cc1-c1ncccn1	InChI=1S/C22H21ClF2N6O/c1-13-4-2-7-31(19(13)12-30-22-28-10-14(23)11-29-22)21(32)16-9-18(25)17(24)8-15(16)20-26-5-3-6-27-20/h3,5-6,8-11,13,19H,2,4,7,12H2,1H3,(H,28,29,30)/t13-,19-/m1/s1	SBTWFFJFXDIIKU-BFUOFWGJSA-N	373477	((2S,3R)-2-(((5-chloropyrimidin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(4,5-difluoro-2-(pyrimidin-2-yl)phenyl)methanone::US9896452, Ex. A244	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373477	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373477&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117729441	404342566							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741429	C[C@@H]1CCCN([C@@H]1CNc1ccc(Cl)cn1)C(=O)c1cc(F)c(F)cc1-n1nccn1	InChI=1S/C21H21ClF2N6O/c1-13-3-2-8-29(19(13)12-26-20-5-4-14(22)11-25-20)21(31)15-9-16(23)17(24)10-18(15)30-27-6-7-28-30/h4-7,9-11,13,19H,2-3,8,12H2,1H3,(H,25,26)/t13-,19-/m1/s1	KWDPEBXJJHIYJH-BFUOFWGJSA-N	373478	((2S,3R)-2-(((5-chloropyridin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(4,5-difluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A246	Orexin/Hypocretin receptor type 1	Homo sapiens		>100.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373478	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373478&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727943	404342567							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741430	C[C@@H]1CCCN([C@@H]1CNc1ccc(Cl)cn1)C(=O)c1cc(F)c(F)cc1-n1nccn1	InChI=1S/C21H21ClF2N6O/c1-13-3-2-8-29(19(13)12-26-20-5-4-14(22)11-25-20)21(31)15-9-16(23)17(24)10-18(15)30-27-6-7-28-30/h4-7,9-11,13,19H,2-3,8,12H2,1H3,(H,25,26)/t13-,19-/m1/s1	KWDPEBXJJHIYJH-BFUOFWGJSA-N	373478	((2S,3R)-2-(((5-chloropyridin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(4,5-difluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A246	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373478	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373478&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727943	404342567							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741431	C[C@@H]1CCCN([C@@H]1CNc1ncc(Cl)cn1)C(=O)c1cc(F)c(F)cc1-n1nccn1	InChI=1S/C20H20ClF2N7O/c1-12-3-2-6-29(18(12)11-26-20-24-9-13(21)10-25-20)19(31)14-7-15(22)16(23)8-17(14)30-27-4-5-28-30/h4-5,7-10,12,18H,2-3,6,11H2,1H3,(H,24,25,26)/t12-,18-/m1/s1	CYYXSJPAPWKBRF-KZULUSFZSA-N	373479	((2S,3R)-2-(((5-chloropyrimidin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(4,5-difluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A247	Orexin/Hypocretin receptor type 1	Homo sapiens		>100.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373479	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373479&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728124	404342568							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741432	C[C@@H]1CCCN([C@@H]1CNc1ncc(Cl)cn1)C(=O)c1cc(F)c(F)cc1-n1nccn1	InChI=1S/C20H20ClF2N7O/c1-12-3-2-6-29(18(12)11-26-20-24-9-13(21)10-25-20)19(31)14-7-15(22)16(23)8-17(14)30-27-4-5-28-30/h4-5,7-10,12,18H,2-3,6,11H2,1H3,(H,24,25,26)/t12-,18-/m1/s1	CYYXSJPAPWKBRF-KZULUSFZSA-N	373479	((2S,3R)-2-(((5-chloropyrimidin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(4,5-difluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A247	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373479	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373479&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117728124	404342568							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741433	C[C@@H]1CCCN([C@@H]1CNc1ncc(cn1)C(F)(F)F)C(=O)c1cc(F)c(F)cc1-n1nccn1	InChI=1S/C21H20F5N7O/c1-12-3-2-6-32(18(12)11-29-20-27-9-13(10-28-20)21(24,25)26)19(34)14-7-15(22)16(23)8-17(14)33-30-4-5-31-33/h4-5,7-10,12,18H,2-3,6,11H2,1H3,(H,27,28,29)/t12-,18-/m1/s1	BLTQXEXWVIEIIZ-KZULUSFZSA-N	373480	(4,5-difluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidin-1-yl)methanone::US9896452, Ex. A248	Orexin/Hypocretin receptor type 1	Homo sapiens		 20.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373480	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373480&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727795	404342569							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741434	C[C@@H]1CCCN([C@@H]1CNc1ncc(cn1)C(F)(F)F)C(=O)c1cc(F)c(F)cc1-n1nccn1	InChI=1S/C21H20F5N7O/c1-12-3-2-6-32(18(12)11-29-20-27-9-13(10-28-20)21(24,25)26)19(34)14-7-15(22)16(23)8-17(14)33-30-4-5-31-33/h4-5,7-10,12,18H,2-3,6,11H2,1H3,(H,27,28,29)/t12-,18-/m1/s1	BLTQXEXWVIEIIZ-KZULUSFZSA-N	373480	(4,5-difluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidin-1-yl)methanone::US9896452, Ex. A248	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373480	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373480&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727795	404342569							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741435	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1cc(F)c(F)cc1-n1nccn1	InChI=1S/C22H21F5N6O/c1-13-3-2-8-32(19(13)12-29-20-5-4-14(11-28-20)22(25,26)27)21(34)15-9-16(23)17(24)10-18(15)33-30-6-7-31-33/h4-7,9-11,13,19H,2-3,8,12H2,1H3,(H,28,29)/t13-,19-/m1/s1	BLNYTJNINCWWFT-BFUOFWGJSA-N	373481	(4,5-difluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)methanone::US9896452, Ex. A249	Orexin/Hypocretin receptor type 1	Homo sapiens		 18.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373481	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373481&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727968	404342570							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741436	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1cc(F)c(F)cc1-n1nccn1	InChI=1S/C22H21F5N6O/c1-13-3-2-8-32(19(13)12-29-20-5-4-14(11-28-20)22(25,26)27)21(34)15-9-16(23)17(24)10-18(15)33-30-6-7-31-33/h4-7,9-11,13,19H,2-3,8,12H2,1H3,(H,28,29)/t13-,19-/m1/s1	BLNYTJNINCWWFT-BFUOFWGJSA-N	373481	(4,5-difluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)methanone::US9896452, Ex. A249	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373481	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373481&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727968	404342570							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741437	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1ccc(F)cc1-n1nccn1	InChI=1S/C22H22F4N6O/c1-14-3-2-10-31(19(14)13-28-20-7-4-15(12-27-20)22(24,25)26)21(33)17-6-5-16(23)11-18(17)32-29-8-9-30-32/h4-9,11-12,14,19H,2-3,10,13H2,1H3,(H,27,28)/t14-,19-/m1/s1	NMVMHYYUBADCCG-AUUYWEPGSA-N	373482	(4-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)methanone::US9896452, Ex. A250	Orexin/Hypocretin receptor type 1	Homo sapiens		 47.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373482	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373482&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727697	404342571							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741438	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1ccc(F)cc1-n1nccn1	InChI=1S/C22H22F4N6O/c1-14-3-2-10-31(19(14)13-28-20-7-4-15(12-27-20)22(24,25)26)21(33)17-6-5-16(23)11-18(17)32-29-8-9-30-32/h4-9,11-12,14,19H,2-3,10,13H2,1H3,(H,27,28)/t14-,19-/m1/s1	NMVMHYYUBADCCG-AUUYWEPGSA-N	373482	(4-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)methanone::US9896452, Ex. A250	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373482	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373482&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727697	404342571							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741439	C[C@@H]1CCCN([C@@H]1CNc1ncc(cn1)C(F)(F)F)C(=O)c1ccc(F)cc1-n1nccn1	InChI=1S/C21H21F4N7O/c1-13-3-2-8-31(18(13)12-28-20-26-10-14(11-27-20)21(23,24)25)19(33)16-5-4-15(22)9-17(16)32-29-6-7-30-32/h4-7,9-11,13,18H,2-3,8,12H2,1H3,(H,26,27,28)/t13-,18-/m1/s1	AUWCKIUJWSEYIL-FZKQIMNGSA-N	373483	(4-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidin-1-yl)methanone::US9896452, Ex. A251	Orexin/Hypocretin receptor type 1	Homo sapiens		 58.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373483	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373483&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727791	404342572							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741440	C[C@@H]1CCCN([C@@H]1CNc1ncc(cn1)C(F)(F)F)C(=O)c1ccc(F)cc1-n1nccn1	InChI=1S/C21H21F4N7O/c1-13-3-2-8-31(18(13)12-28-20-26-10-14(11-27-20)21(23,24)25)19(33)16-5-4-15(22)9-17(16)32-29-6-7-30-32/h4-7,9-11,13,18H,2-3,8,12H2,1H3,(H,26,27,28)/t13-,18-/m1/s1	AUWCKIUJWSEYIL-FZKQIMNGSA-N	373483	(4-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidin-1-yl)methanone::US9896452, Ex. A251	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373483	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373483&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727791	404342572							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741441	C[C@@H]1CCCN([C@@H]1CNc1ccc(Cl)cn1)C(=O)c1cccc(F)c1-n1nccn1	InChI=1S/C21H22ClFN6O/c1-14-4-3-11-28(18(14)13-25-19-8-7-15(22)12-24-19)21(30)16-5-2-6-17(23)20(16)29-26-9-10-27-29/h2,5-10,12,14,18H,3-4,11,13H2,1H3,(H,24,25)/t14-,18-/m1/s1	FBNSFKNHZMQGLH-RDTXWAMCSA-N	373484	((2S,3R)-2-(((5-chloropyridin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(3-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A254	Orexin/Hypocretin receptor type 1	Homo sapiens		 37.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373484	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373484&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727784	404342573							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741442	C[C@@H]1CCCN([C@@H]1CNc1ccc(Cl)cn1)C(=O)c1cccc(F)c1-n1nccn1	InChI=1S/C21H22ClFN6O/c1-14-4-3-11-28(18(14)13-25-19-8-7-15(22)12-24-19)21(30)16-5-2-6-17(23)20(16)29-26-9-10-27-29/h2,5-10,12,14,18H,3-4,11,13H2,1H3,(H,24,25)/t14-,18-/m1/s1	FBNSFKNHZMQGLH-RDTXWAMCSA-N	373484	((2S,3R)-2-(((5-chloropyridin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(3-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A254	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373484	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373484&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727784	404342573							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741443	C[C@@H]1CCCN([C@@H]1CNc1ncc(Cl)cn1)C(=O)c1cccc(F)c1-n1nccn1	InChI=1S/C20H21ClFN7O/c1-13-4-3-9-28(17(13)12-25-20-23-10-14(21)11-24-20)19(30)15-5-2-6-16(22)18(15)29-26-7-8-27-29/h2,5-8,10-11,13,17H,3-4,9,12H2,1H3,(H,23,24,25)/t13-,17-/m1/s1	NJEKJYWFBCFQAD-CXAGYDPISA-N	373485	((2S,3R)-2-(((5-chloropyrimidin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(3-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A255	Orexin/Hypocretin receptor type 1	Homo sapiens		 41.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373485	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373485&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727633	404342574							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741444	C[C@@H]1CCCN([C@@H]1CNc1ncc(Cl)cn1)C(=O)c1cccc(F)c1-n1nccn1	InChI=1S/C20H21ClFN7O/c1-13-4-3-9-28(17(13)12-25-20-23-10-14(21)11-24-20)19(30)15-5-2-6-16(22)18(15)29-26-7-8-27-29/h2,5-8,10-11,13,17H,3-4,9,12H2,1H3,(H,23,24,25)/t13-,17-/m1/s1	NJEKJYWFBCFQAD-CXAGYDPISA-N	373485	((2S,3R)-2-(((5-chloropyrimidin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(3-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A255	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373485	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373485&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727633	404342574							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741445	C[C@@H]1CCCN([C@@H]1CNc1ncc(cn1)C(F)(F)F)C(=O)c1cccc(F)c1-n1nccn1	InChI=1S/C21H21F4N7O/c1-13-4-3-9-31(17(13)12-28-20-26-10-14(11-27-20)21(23,24)25)19(33)15-5-2-6-16(22)18(15)32-29-7-8-30-32/h2,5-8,10-11,13,17H,3-4,9,12H2,1H3,(H,26,27,28)/t13-,17-/m1/s1	LJNCPNLQIFQRJM-CXAGYDPISA-N	373486	(3-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidin-1-yl)methanone::US9896452, Ex. A256	Orexin/Hypocretin receptor type 1	Homo sapiens		 5.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373486	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373486&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727779	404342575							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741446	C[C@@H]1CCCN([C@@H]1CNc1ncc(cn1)C(F)(F)F)C(=O)c1cccc(F)c1-n1nccn1	InChI=1S/C21H21F4N7O/c1-13-4-3-9-31(17(13)12-28-20-26-10-14(11-27-20)21(23,24)25)19(33)15-5-2-6-16(22)18(15)32-29-7-8-30-32/h2,5-8,10-11,13,17H,3-4,9,12H2,1H3,(H,26,27,28)/t13-,17-/m1/s1	LJNCPNLQIFQRJM-CXAGYDPISA-N	373486	(3-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidin-1-yl)methanone::US9896452, Ex. A256	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373486	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373486&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727779	404342575							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741447	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1cccc(F)c1-n1nccn1	InChI=1S/C22H22F4N6O/c1-14-4-3-11-31(18(14)13-28-19-8-7-15(12-27-19)22(24,25)26)21(33)16-5-2-6-17(23)20(16)32-29-9-10-30-32/h2,5-10,12,14,18H,3-4,11,13H2,1H3,(H,27,28)/t14-,18-/m1/s1	CSFKQHYLUJBRPC-RDTXWAMCSA-N	373487	(3-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)methanone::US9896452, Ex. A257	Orexin/Hypocretin receptor type 1	Homo sapiens		 4.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373487	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373487&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728156	404342576							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741448	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1cccc(F)c1-n1nccn1	InChI=1S/C22H22F4N6O/c1-14-4-3-11-31(18(14)13-28-19-8-7-15(12-27-19)22(24,25)26)21(33)16-5-2-6-17(23)20(16)32-29-9-10-30-32/h2,5-10,12,14,18H,3-4,11,13H2,1H3,(H,27,28)/t14-,18-/m1/s1	CSFKQHYLUJBRPC-RDTXWAMCSA-N	373487	(3-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)methanone::US9896452, Ex. A257	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373487	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373487&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117728156	404342576							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741449	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1c(F)cccc1-n1nccn1	InChI=1S/C22H22F4N6O/c1-14-4-3-11-31(18(14)13-28-19-8-7-15(12-27-19)22(24,25)26)21(33)20-16(23)5-2-6-17(20)32-29-9-10-30-32/h2,5-10,12,14,18H,3-4,11,13H2,1H3,(H,27,28)/t14-,18-/m1/s1	VEINLLMPZRUEHL-RDTXWAMCSA-N	373488	(2-fluoro-6-(2H-1,2,3-triazol-2-yl)phenyl)((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)methanone::US9896452, Ex. A258	Orexin/Hypocretin receptor type 1	Homo sapiens		 4.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373488	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373488&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727631	404342577							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741450	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1c(F)cccc1-n1nccn1	InChI=1S/C22H22F4N6O/c1-14-4-3-11-31(18(14)13-28-19-8-7-15(12-27-19)22(24,25)26)21(33)20-16(23)5-2-6-17(20)32-29-9-10-30-32/h2,5-10,12,14,18H,3-4,11,13H2,1H3,(H,27,28)/t14-,18-/m1/s1	VEINLLMPZRUEHL-RDTXWAMCSA-N	373488	(2-fluoro-6-(2H-1,2,3-triazol-2-yl)phenyl)((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)methanone::US9896452, Ex. A258	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373488	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373488&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727631	404342577							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741451	C[C@@H]1CCCN([C@@H]1CNc1ncc(cn1)C(F)(F)F)C(=O)c1c(F)cccc1-n1nccn1	InChI=1S/C21H21F4N7O/c1-13-4-3-9-31(17(13)12-28-20-26-10-14(11-27-20)21(23,24)25)19(33)18-15(22)5-2-6-16(18)32-29-7-8-30-32/h2,5-8,10-11,13,17H,3-4,9,12H2,1H3,(H,26,27,28)/t13-,17-/m1/s1	PSTXYXVIQCDKBC-CXAGYDPISA-N	373489	(2-fluoro-6-(2H-1,2,3-triazol-2-yl)phenyl)((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidin-1-yl)methanone::US9896452, Ex. A259	Orexin/Hypocretin receptor type 1	Homo sapiens		 9.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373489	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373489&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727962	404342578							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741452	C[C@@H]1CCCN([C@@H]1CNc1ncc(cn1)C(F)(F)F)C(=O)c1c(F)cccc1-n1nccn1	InChI=1S/C21H21F4N7O/c1-13-4-3-9-31(17(13)12-28-20-26-10-14(11-27-20)21(23,24)25)19(33)18-15(22)5-2-6-16(18)32-29-7-8-30-32/h2,5-8,10-11,13,17H,3-4,9,12H2,1H3,(H,26,27,28)/t13-,17-/m1/s1	PSTXYXVIQCDKBC-CXAGYDPISA-N	373489	(2-fluoro-6-(2H-1,2,3-triazol-2-yl)phenyl)((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidin-1-yl)methanone::US9896452, Ex. A259	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373489	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373489&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727962	404342578							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741453	C[C@@H]1CCCN([C@@H]1CNc1ncc(Cl)cn1)C(=O)c1c(F)cccc1-n1nccn1	InChI=1S/C20H21ClFN7O/c1-13-4-3-9-28(17(13)12-25-20-23-10-14(21)11-24-20)19(30)18-15(22)5-2-6-16(18)29-26-7-8-27-29/h2,5-8,10-11,13,17H,3-4,9,12H2,1H3,(H,23,24,25)/t13-,17-/m1/s1	VNXUTKPAQKSIRB-CXAGYDPISA-N	373490	((2S,3R)-2-(((5-chloropyrimidin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(2-fluoro-6-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A260	Orexin/Hypocretin receptor type 1	Homo sapiens		 85.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373490	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373490&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727844	404342579							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741454	C[C@@H]1CCCN([C@@H]1CNc1ncc(Cl)cn1)C(=O)c1c(F)cccc1-n1nccn1	InChI=1S/C20H21ClFN7O/c1-13-4-3-9-28(17(13)12-25-20-23-10-14(21)11-24-20)19(30)18-15(22)5-2-6-16(18)29-26-7-8-27-29/h2,5-8,10-11,13,17H,3-4,9,12H2,1H3,(H,23,24,25)/t13-,17-/m1/s1	VNXUTKPAQKSIRB-CXAGYDPISA-N	373490	((2S,3R)-2-(((5-chloropyrimidin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(2-fluoro-6-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A260	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373490	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373490&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727844	404342579							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741455	C[C@@H]1CCCN([C@@H]1CNc1ccc(Cl)cn1)C(=O)c1c(F)cccc1-n1nccn1	InChI=1S/C21H22ClFN6O/c1-14-4-3-11-28(18(14)13-25-19-8-7-15(22)12-24-19)21(30)20-16(23)5-2-6-17(20)29-26-9-10-27-29/h2,5-10,12,14,18H,3-4,11,13H2,1H3,(H,24,25)/t14-,18-/m1/s1	MCCXVRKOAOCZBC-RDTXWAMCSA-N	373491	((2S,3R)-2-(((5-chloropyridin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(2-fluoro-6-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A261	Orexin/Hypocretin receptor type 1	Homo sapiens		 5.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373491	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373491&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727781	404342580							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741456	C[C@@H]1CCCN([C@@H]1CNc1ccc(Cl)cn1)C(=O)c1c(F)cccc1-n1nccn1	InChI=1S/C21H22ClFN6O/c1-14-4-3-11-28(18(14)13-25-19-8-7-15(22)12-24-19)21(30)20-16(23)5-2-6-17(20)29-26-9-10-27-29/h2,5-10,12,14,18H,3-4,11,13H2,1H3,(H,24,25)/t14-,18-/m1/s1	MCCXVRKOAOCZBC-RDTXWAMCSA-N	373491	((2S,3R)-2-(((5-chloropyridin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(2-fluoro-6-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A261	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373491	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373491&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727781	404342580							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741457	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1cccc(C)c1-n1nccn1	InChI=1S/C23H25F3N6O/c1-15-6-4-12-31(19(15)14-28-20-9-8-17(13-27-20)23(24,25)26)22(33)18-7-3-5-16(2)21(18)32-29-10-11-30-32/h3,5,7-11,13,15,19H,4,6,12,14H2,1-2H3,(H,27,28)/t15-,19-/m1/s1	NZQAWBOIBGEHDJ-DNVCBOLYSA-N	373492	((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(3-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A266	Orexin/Hypocretin receptor type 1	Homo sapiens		 4.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373492	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373492&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727722	404342581							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741458	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1cccc(C)c1-n1nccn1	InChI=1S/C23H25F3N6O/c1-15-6-4-12-31(19(15)14-28-20-9-8-17(13-27-20)23(24,25)26)22(33)18-7-3-5-16(2)21(18)32-29-10-11-30-32/h3,5,7-11,13,15,19H,4,6,12,14H2,1-2H3,(H,27,28)/t15-,19-/m1/s1	NZQAWBOIBGEHDJ-DNVCBOLYSA-N	373492	((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(3-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A266	Orexin receptor type 2	Homo sapiens		 1100							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373492	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373492&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727722	404342581							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741459	C[C@@H]1CCCN([C@@H]1CNc1ncc(cn1)C(F)(F)F)C(=O)c1cccc(C)c1-n1nccn1	InChI=1S/C22H24F3N7O/c1-14-6-4-10-31(18(14)13-28-21-26-11-16(12-27-21)22(23,24)25)20(33)17-7-3-5-15(2)19(17)32-29-8-9-30-32/h3,5,7-9,11-12,14,18H,4,6,10,13H2,1-2H3,(H,26,27,28)/t14-,18-/m1/s1	NMUJFWSVDZIYRN-RDTXWAMCSA-N	373493	((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidin-1-yl)(3-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A267	Orexin/Hypocretin receptor type 1	Homo sapiens		 6.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373493	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373493&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728265	404342582							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741460	C[C@@H]1CCCN([C@@H]1CNc1ncc(cn1)C(F)(F)F)C(=O)c1cccc(C)c1-n1nccn1	InChI=1S/C22H24F3N7O/c1-14-6-4-10-31(18(14)13-28-21-26-11-16(12-27-21)22(23,24)25)20(33)17-7-3-5-15(2)19(17)32-29-8-9-30-32/h3,5,7-9,11-12,14,18H,4,6,10,13H2,1-2H3,(H,26,27,28)/t14-,18-/m1/s1	NMUJFWSVDZIYRN-RDTXWAMCSA-N	373493	((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidin-1-yl)(3-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A267	Orexin receptor type 2	Homo sapiens		 2600							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373493	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373493&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117728265	404342582							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741461	C[C@@H]1CCCN([C@@H]1CNc1ncc(Cl)cn1)C(=O)c1cccc(C)c1-n1nccn1	InChI=1S/C21H24ClN7O/c1-14-6-4-10-28(18(14)13-25-21-23-11-16(22)12-24-21)20(30)17-7-3-5-15(2)19(17)29-26-8-9-27-29/h3,5,7-9,11-12,14,18H,4,6,10,13H2,1-2H3,(H,23,24,25)/t14-,18-/m1/s1	NCFXFEJAUKCAFU-RDTXWAMCSA-N	373494	((2S,3R)-2-(((5-chloropyrimidin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(3-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A268	Orexin/Hypocretin receptor type 1	Homo sapiens		 3.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373494	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373494&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728217	404342583							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741462	C[C@@H]1CCCN([C@@H]1CNc1ncc(Cl)cn1)C(=O)c1cccc(C)c1-n1nccn1	InChI=1S/C21H24ClN7O/c1-14-6-4-10-28(18(14)13-25-21-23-11-16(22)12-24-21)20(30)17-7-3-5-15(2)19(17)29-26-8-9-27-29/h3,5,7-9,11-12,14,18H,4,6,10,13H2,1-2H3,(H,23,24,25)/t14-,18-/m1/s1	NCFXFEJAUKCAFU-RDTXWAMCSA-N	373494	((2S,3R)-2-(((5-chloropyrimidin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(3-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A268	Orexin receptor type 2	Homo sapiens		 1700							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373494	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373494&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117728217	404342583							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741463	C[C@@H]1CCCN([C@@H]1CNc1ncc(Cl)cn1)C(=O)c1ccc(C)cc1-n1nccn1	InChI=1S/C21H24ClN7O/c1-14-5-6-17(18(10-14)29-26-7-8-27-29)20(30)28-9-3-4-15(2)19(28)13-25-21-23-11-16(22)12-24-21/h5-8,10-12,15,19H,3-4,9,13H2,1-2H3,(H,23,24,25)/t15-,19-/m1/s1	MQNUXSQQMWLMDO-DNVCBOLYSA-N	373495	((2S,3R)-2-(((5-chloropyrimidin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(4-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A271	Orexin/Hypocretin receptor type 1	Homo sapiens		 86.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373495	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373495&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728294	404342584							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741464	C[C@@H]1CCCN([C@@H]1CNc1ncc(Cl)cn1)C(=O)c1ccc(C)cc1-n1nccn1	InChI=1S/C21H24ClN7O/c1-14-5-6-17(18(10-14)29-26-7-8-27-29)20(30)28-9-3-4-15(2)19(28)13-25-21-23-11-16(22)12-24-21/h5-8,10-12,15,19H,3-4,9,13H2,1-2H3,(H,23,24,25)/t15-,19-/m1/s1	MQNUXSQQMWLMDO-DNVCBOLYSA-N	373495	((2S,3R)-2-(((5-chloropyrimidin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(4-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A271	Orexin receptor type 2	Homo sapiens		 9400							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373495	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373495&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117728294	404342584							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741465	C[C@@H]1CCCN([C@@H]1CNc1ncc(cn1)C(F)(F)F)C(=O)c1ccc(C)cc1-n1nccn1	InChI=1S/C22H24F3N7O/c1-14-5-6-17(18(10-14)32-29-7-8-30-32)20(33)31-9-3-4-15(2)19(31)13-28-21-26-11-16(12-27-21)22(23,24)25/h5-8,10-12,15,19H,3-4,9,13H2,1-2H3,(H,26,27,28)/t15-,19-/m1/s1	QAVRGTUUHZZCIU-DNVCBOLYSA-N	373496	((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidin-1-yl)(4-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A272	Orexin/Hypocretin receptor type 1	Homo sapiens		 14.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373496	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373496&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727878	404342585							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741466	C[C@@H]1CCCN([C@@H]1CNc1ncc(cn1)C(F)(F)F)C(=O)c1ccc(C)cc1-n1nccn1	InChI=1S/C22H24F3N7O/c1-14-5-6-17(18(10-14)32-29-7-8-30-32)20(33)31-9-3-4-15(2)19(31)13-28-21-26-11-16(12-27-21)22(23,24)25/h5-8,10-12,15,19H,3-4,9,13H2,1-2H3,(H,26,27,28)/t15-,19-/m1/s1	QAVRGTUUHZZCIU-DNVCBOLYSA-N	373496	((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidin-1-yl)(4-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A272	Orexin receptor type 2	Homo sapiens		 8500							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373496	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373496&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727878	404342585							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741467	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1ccc(C)cc1-n1nccn1	InChI=1S/C23H25F3N6O/c1-15-5-7-18(19(12-15)32-29-9-10-30-32)22(33)31-11-3-4-16(2)20(31)14-28-21-8-6-17(13-27-21)23(24,25)26/h5-10,12-13,16,20H,3-4,11,14H2,1-2H3,(H,27,28)/t16-,20-/m1/s1	HNGVVNFIUVFIMF-OXQOHEQNSA-N	373497	((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(4-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A273	Orexin/Hypocretin receptor type 1	Homo sapiens		 6.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373497	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373497&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728242	404342586							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741468	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1ccc(C)cc1-n1nccn1	InChI=1S/C23H25F3N6O/c1-15-5-7-18(19(12-15)32-29-9-10-30-32)22(33)31-11-3-4-16(2)20(31)14-28-21-8-6-17(13-27-21)23(24,25)26/h5-10,12-13,16,20H,3-4,11,14H2,1-2H3,(H,27,28)/t16-,20-/m1/s1	HNGVVNFIUVFIMF-OXQOHEQNSA-N	373497	((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(4-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A273	Orexin receptor type 2	Homo sapiens		 4400							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373497	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373497&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117728242	404342586							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741469	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1cccc(C)c1-c1ncccn1	InChI=1S/C25H26F3N5O/c1-16-7-4-13-33(20(16)15-32-21-10-9-18(14-31-21)25(26,27)28)24(34)19-8-3-6-17(2)22(19)23-29-11-5-12-30-23/h3,5-6,8-12,14,16,20H,4,7,13,15H2,1-2H3,(H,31,32)/t16-,20-/m1/s1	ADCIAWCGFADFAQ-OXQOHEQNSA-N	373498	((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(3-methyl-2-(pyrimidin-2-yl)phenyl)methanone::US9896452, Ex. A298	Orexin/Hypocretin receptor type 1	Homo sapiens		 5.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373498	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373498&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728000	404342587							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741470	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1cccc(C)c1-c1ncccn1	InChI=1S/C25H26F3N5O/c1-16-7-4-13-33(20(16)15-32-21-10-9-18(14-31-21)25(26,27)28)24(34)19-8-3-6-17(2)22(19)23-29-11-5-12-30-23/h3,5-6,8-12,14,16,20H,4,7,13,15H2,1-2H3,(H,31,32)/t16-,20-/m1/s1	ADCIAWCGFADFAQ-OXQOHEQNSA-N	373498	((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(3-methyl-2-(pyrimidin-2-yl)phenyl)methanone::US9896452, Ex. A298	Orexin receptor type 2	Homo sapiens		 483							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373498	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373498&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117728000	404342587							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741471	C[C@@H]1CCCN([C@@H]1CNc1ncc(cn1)C(F)(F)F)C(=O)c1cccc(C)c1-c1ncccn1	InChI=1S/C24H25F3N6O/c1-15-7-4-11-33(19(15)14-32-23-30-12-17(13-31-23)24(25,26)27)22(34)18-8-3-6-16(2)20(18)21-28-9-5-10-29-21/h3,5-6,8-10,12-13,15,19H,4,7,11,14H2,1-2H3,(H,30,31,32)/t15-,19-/m1/s1	ARTSNUKMDAQOOP-DNVCBOLYSA-N	373499	((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidin-1-yl)(3-methyl-2-(pyrimidin-2-yl)phenyl)methanone::US9896452, Ex. A299	Orexin/Hypocretin receptor type 1	Homo sapiens		 3.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373499	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373499&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727811	404342588							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741472	C[C@@H]1CCCN([C@@H]1CNc1ncc(cn1)C(F)(F)F)C(=O)c1cccc(C)c1-c1ncccn1	InChI=1S/C24H25F3N6O/c1-15-7-4-11-33(19(15)14-32-23-30-12-17(13-31-23)24(25,26)27)22(34)18-8-3-6-16(2)20(18)21-28-9-5-10-29-21/h3,5-6,8-10,12-13,15,19H,4,7,11,14H2,1-2H3,(H,30,31,32)/t15-,19-/m1/s1	ARTSNUKMDAQOOP-DNVCBOLYSA-N	373499	((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidin-1-yl)(3-methyl-2-(pyrimidin-2-yl)phenyl)methanone::US9896452, Ex. A299	Orexin receptor type 2	Homo sapiens		 2350							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373499	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373499&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727811	404342588							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741473	C[C@@H]1CCCN([C@@H]1CNc1ncc(cn1)C(F)(F)F)C(=O)c1c(C)cccc1-c1ncccn1	InChI=1S/C24H25F3N6O/c1-15-7-4-11-33(19(15)14-32-23-30-12-17(13-31-23)24(25,26)27)22(34)20-16(2)6-3-8-18(20)21-28-9-5-10-29-21/h3,5-6,8-10,12-13,15,19H,4,7,11,14H2,1-2H3,(H,30,31,32)/t15-,19-/m1/s1	NXMJNUNCOFRTTE-DNVCBOLYSA-N	373500	((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidin-1-yl)(2-methyl-6-(pyrimidin-2-yl)phenyl)methanone::US9896452, Ex. A307	Orexin/Hypocretin receptor type 1	Homo sapiens		 250							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373500	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373500&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728146	404342589							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741474	C[C@@H]1CCCN([C@@H]1CNc1ncc(cn1)C(F)(F)F)C(=O)c1c(C)cccc1-c1ncccn1	InChI=1S/C24H25F3N6O/c1-15-7-4-11-33(19(15)14-32-23-30-12-17(13-31-23)24(25,26)27)22(34)20-16(2)6-3-8-18(20)21-28-9-5-10-29-21/h3,5-6,8-10,12-13,15,19H,4,7,11,14H2,1-2H3,(H,30,31,32)/t15-,19-/m1/s1	NXMJNUNCOFRTTE-DNVCBOLYSA-N	373500	((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidin-1-yl)(2-methyl-6-(pyrimidin-2-yl)phenyl)methanone::US9896452, Ex. A307	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373500	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373500&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117728146	404342589							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741475	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1cc(F)ccc1-n1nccn1	InChI=1S/C22H22F4N6O/c1-14-3-2-10-31(19(14)13-28-20-7-4-15(12-27-20)22(24,25)26)21(33)17-11-16(23)5-6-18(17)32-29-8-9-30-32/h4-9,11-12,14,19H,2-3,10,13H2,1H3,(H,27,28)/t14-,19-/m1/s1	CNACQXVIJMRLGT-AUUYWEPGSA-N	373501	((2S,3R)-2-(((5-chloropyrimidin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(3-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A310	Orexin/Hypocretin receptor type 1	Homo sapiens		 3.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373501	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373501&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117732715	404342590							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741476	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1cc(F)ccc1-n1nccn1	InChI=1S/C22H22F4N6O/c1-14-3-2-10-31(19(14)13-28-20-7-4-15(12-27-20)22(24,25)26)21(33)17-11-16(23)5-6-18(17)32-29-8-9-30-32/h4-9,11-12,14,19H,2-3,10,13H2,1H3,(H,27,28)/t14-,19-/m1/s1	CNACQXVIJMRLGT-AUUYWEPGSA-N	373501	((2S,3R)-2-(((5-chloropyrimidin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)(3-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone::US9896452, Ex. A310	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373501	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373501&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117732715	404342590							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741477	C[C@H]1CCCN([C@@H]1CNc1ncc(cn1)C(F)(F)F)C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C23H23F4N5OS/c1-13-4-3-9-32(18(13)12-30-22-28-10-16(11-29-22)23(25,26)27)21(33)19-20(34-14(2)31-19)15-5-7-17(24)8-6-15/h5-8,10-11,13,18H,3-4,9,12H2,1-2H3,(H,28,29,30)/t13-,18+/m0/s1	BPQDADCPUWZLIG-SCLBCKFNSA-N	373134	(5-(4-fluorophenyl)-2-methylthiazol-4-yl)((2S,3S)-3-methyl-2-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidin-1-yl)methanone::US9896452, Ex. A311	Orexin/Hypocretin receptor type 1	Homo sapiens		 27.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373134	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373134&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117732716	404342239							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741478	C[C@H]1CCCN([C@@H]1CNc1ncc(cn1)C(F)(F)F)C(=O)c1nc(C)sc1-c1ccc(F)cc1	InChI=1S/C23H23F4N5OS/c1-13-4-3-9-32(18(13)12-30-22-28-10-16(11-29-22)23(25,26)27)21(33)19-20(34-14(2)31-19)15-5-7-17(24)8-6-15/h5-8,10-11,13,18H,3-4,9,12H2,1-2H3,(H,28,29,30)/t13-,18+/m0/s1	BPQDADCPUWZLIG-SCLBCKFNSA-N	373134	(5-(4-fluorophenyl)-2-methylthiazol-4-yl)((2S,3S)-3-methyl-2-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidin-1-yl)methanone::US9896452, Ex. A311	Orexin receptor type 2	Homo sapiens		 3100							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373134	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373134&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117732716	404342239							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741479	Cc1ccc(-c2ncccn2)c(c1)C(=O)N1CCC(F)(F)CC1CNc1ncc(cn1)C(F)(F)F	InChI=1S/C23H21F5N6O/c1-14-3-4-17(19-29-6-2-7-30-19)18(9-14)20(35)34-8-5-22(24,25)10-16(34)13-33-21-31-11-15(12-32-21)23(26,27)28/h2-4,6-7,9,11-12,16H,5,8,10,13H2,1H3,(H,31,32,33)	RTLNETICFGUGJA-UHFFFAOYSA-N	373502	(S)-(4,4-difluoro-2-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(pyrimidin-2-yl)phenyl)methanone::US9896452, Ex. A312	Orexin/Hypocretin receptor type 1	Homo sapiens		 144							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373502	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373502&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727663	404342591							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741480	Cc1ccc(-c2ncccn2)c(c1)C(=O)N1CCC(F)(F)CC1CNc1ncc(cn1)C(F)(F)F	InChI=1S/C23H21F5N6O/c1-14-3-4-17(19-29-6-2-7-30-19)18(9-14)20(35)34-8-5-22(24,25)10-16(34)13-33-21-31-11-15(12-32-21)23(26,27)28/h2-4,6-7,9,11-12,16H,5,8,10,13H2,1H3,(H,31,32,33)	RTLNETICFGUGJA-UHFFFAOYSA-N	373502	(S)-(4,4-difluoro-2-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(pyrimidin-2-yl)phenyl)methanone::US9896452, Ex. A312	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373502	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373502&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727663	404342591							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741481	C[C@@H]1CCCN([C@@H]1CNc1ncc(cn1)C(F)(F)F)C(=O)c1ccccc1-n1nccn1	InChI=1S/C21H22F3N7O/c1-14-5-4-10-30(18(14)13-27-20-25-11-15(12-26-20)21(22,23)24)19(32)16-6-2-3-7-17(16)31-28-8-9-29-31/h2-3,6-9,11-12,14,18H,4-5,10,13H2,1H3,(H,25,26,27)/t14-,18-/m1/s1	AZURIOSHTDKNNJ-RDTXWAMCSA-N	373503	(2-(2H-1,2,3-triazol-2-yl)phenyl)((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidin-1-yl)methanone::US9896452, Ex. A313	Orexin/Hypocretin receptor type 1	Homo sapiens		 5.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373503	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373503&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728133	404342592							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741482	C[C@@H]1CCCN([C@@H]1CNc1ncc(cn1)C(F)(F)F)C(=O)c1ccccc1-n1nccn1	InChI=1S/C21H22F3N7O/c1-14-5-4-10-30(18(14)13-27-20-25-11-15(12-26-20)21(22,23)24)19(32)16-6-2-3-7-17(16)31-28-8-9-29-31/h2-3,6-9,11-12,14,18H,4-5,10,13H2,1H3,(H,25,26,27)/t14-,18-/m1/s1	AZURIOSHTDKNNJ-RDTXWAMCSA-N	373503	(2-(2H-1,2,3-triazol-2-yl)phenyl)((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidin-1-yl)methanone::US9896452, Ex. A313	Orexin receptor type 2	Homo sapiens		 3600							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373503	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373503&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117728133	404342592							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741483	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1ccccc1-n1nccn1	InChI=1S/C22H23F3N6O/c1-15-5-4-12-30(19(15)14-27-20-9-8-16(13-26-20)22(23,24)25)21(32)17-6-2-3-7-18(17)31-28-10-11-29-31/h2-3,6-11,13,15,19H,4-5,12,14H2,1H3,(H,26,27)/t15-,19-/m1/s1	FCVLRNRCGDIIDA-DNVCBOLYSA-N	373257	US9896452, Ex. A314::US9896452, Example 120::rac-((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(1H-pyrazol-1-yl)phenyl)methanone	Orexin/Hypocretin receptor type 1	Homo sapiens		 2.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373257	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373257&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728107	404342359							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741484	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1ccccc1-n1nccn1	InChI=1S/C22H23F3N6O/c1-15-5-4-12-30(19(15)14-27-20-9-8-16(13-26-20)22(23,24)25)21(32)17-6-2-3-7-18(17)31-28-10-11-29-31/h2-3,6-11,13,15,19H,4-5,12,14H2,1H3,(H,26,27)/t15-,19-/m1/s1	FCVLRNRCGDIIDA-DNVCBOLYSA-N	373257	US9896452, Ex. A314::US9896452, Example 120::rac-((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(1H-pyrazol-1-yl)phenyl)methanone	Orexin receptor type 2	Homo sapiens		 2700							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373257	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373257&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117728107	404342359							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741485	C[C@H]1CCCN([C@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1cc(C)ccc1-c1cnn(C)c1	InChI=1S/C25H28F3N5O/c1-16-6-8-20(18-12-31-32(3)15-18)21(11-16)24(34)33-10-4-5-17(2)22(33)14-30-23-9-7-19(13-29-23)25(26,27)28/h6-9,11-13,15,17,22H,4-5,10,14H2,1-3H3,(H,29,30)/t17-,22-/m0/s1	XHXUTIQEYCEZLE-JTSKRJEESA-N	373505	((2R,3S)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(1-methyl-1H-pyrazol-4-yl)phenyl)methanone::US9896452, Ex. A315	Orexin/Hypocretin receptor type 1	Homo sapiens		 2500							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373505	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373505&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727860	404342593							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741486	C[C@H]1CCCN([C@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1cc(C)ccc1-c1cnn(C)c1	InChI=1S/C25H28F3N5O/c1-16-6-8-20(18-12-31-32(3)15-18)21(11-16)24(34)33-10-4-5-17(2)22(33)14-30-23-9-7-19(13-29-23)25(26,27)28/h6-9,11-13,15,17,22H,4-5,10,14H2,1-3H3,(H,29,30)/t17-,22-/m0/s1	XHXUTIQEYCEZLE-JTSKRJEESA-N	373505	((2R,3S)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(1-methyl-1H-pyrazol-4-yl)phenyl)methanone::US9896452, Ex. A315	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373505	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373505&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727860	404342593							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741487	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1ccccc1-c1ncccn1	InChI=1S/C24H24F3N5O/c1-16-6-4-13-32(20(16)15-31-21-10-9-17(14-30-21)24(25,26)27)23(33)19-8-3-2-7-18(19)22-28-11-5-12-29-22/h2-3,5,7-12,14,16,20H,4,6,13,15H2,1H3,(H,30,31)/t16-,20-/m1/s1	FQSKEAZCYOLTPI-OXQOHEQNSA-N	373506	((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(2-(pyrimidin-2-yl)phenyl)methanone::US9896452, Ex. A316	Orexin/Hypocretin receptor type 1	Homo sapiens		 4.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373506	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373506&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728095	404342594							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741488	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1ccccc1-c1ncccn1	InChI=1S/C24H24F3N5O/c1-16-6-4-13-32(20(16)15-31-21-10-9-17(14-30-21)24(25,26)27)23(33)19-8-3-2-7-18(19)22-28-11-5-12-29-22/h2-3,5,7-12,14,16,20H,4,6,13,15H2,1H3,(H,30,31)/t16-,20-/m1/s1	FQSKEAZCYOLTPI-OXQOHEQNSA-N	373506	((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)(2-(pyrimidin-2-yl)phenyl)methanone::US9896452, Ex. A316	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373506	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373506&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117728095	404342594							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741489	C[C@@H]1CCCN([C@@H]1CNc1ncc(cn1)C(F)(F)F)C(=O)c1ccccc1-c1ncccn1	InChI=1S/C23H23F3N6O/c1-15-6-4-11-32(19(15)14-31-22-29-12-16(13-30-22)23(24,25)26)21(33)18-8-3-2-7-17(18)20-27-9-5-10-28-20/h2-3,5,7-10,12-13,15,19H,4,6,11,14H2,1H3,(H,29,30,31)/t15-,19-/m1/s1	QMXJDHYHTVTCMX-DNVCBOLYSA-N	373507	((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidin-1-yl)(2-(pyrimidin-2-yl)phenyl)methanone::US9896452, Ex. A317	Orexin/Hypocretin receptor type 1	Homo sapiens		 1.000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373507	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373507&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727684	404342595							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741490	C[C@@H]1CCCN([C@@H]1CNc1ncc(cn1)C(F)(F)F)C(=O)c1ccccc1-c1ncccn1	InChI=1S/C23H23F3N6O/c1-15-6-4-11-32(19(15)14-31-22-29-12-16(13-30-22)23(24,25)26)21(33)18-8-3-2-7-17(18)20-27-9-5-10-28-20/h2-3,5,7-10,12-13,15,19H,4,6,11,14H2,1H3,(H,29,30,31)/t15-,19-/m1/s1	QMXJDHYHTVTCMX-DNVCBOLYSA-N	373507	((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidin-1-yl)(2-(pyrimidin-2-yl)phenyl)methanone::US9896452, Ex. A317	Orexin receptor type 2	Homo sapiens		>1000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373507	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373507&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727684	404342595							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741491	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1c(F)c(C)ccc1-n1nccn1	InChI=1S/C23H24F4N6O/c1-14-4-3-11-32(18(14)13-29-19-8-6-16(12-28-19)23(25,26)27)22(34)20-17(33-30-9-10-31-33)7-5-15(2)21(20)24/h5-10,12,14,18H,3-4,11,13H2,1-2H3,(H,28,29)/t14-,18-/m1/s1	GDEMAHDHJCXVNH-RDTXWAMCSA-N	373508	(2-fluoro-3-methyl-6-(2H-1,2,3-triazol-2-yl)phenyl)((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)methanone::US9896452, Ex. A318	Orexin/Hypocretin receptor type 1	Homo sapiens		 7.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373508	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373508&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727883	404342596							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741492	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1c(F)c(C)ccc1-n1nccn1	InChI=1S/C23H24F4N6O/c1-14-4-3-11-32(18(14)13-29-19-8-6-16(12-28-19)23(25,26)27)22(34)20-17(33-30-9-10-31-33)7-5-15(2)21(20)24/h5-10,12,14,18H,3-4,11,13H2,1-2H3,(H,28,29)/t14-,18-/m1/s1	GDEMAHDHJCXVNH-RDTXWAMCSA-N	373508	(2-fluoro-3-methyl-6-(2H-1,2,3-triazol-2-yl)phenyl)((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)methanone::US9896452, Ex. A318	Orexin receptor type 2	Homo sapiens		 2500							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373508	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373508&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727883	404342596							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741493	C[C@@H]1CCCN([C@@H]1CNc1ncc(cn1)C(F)(F)F)C(=O)c1c(F)c(C)ccc1-n1nccn1	InChI=1S/C22H23F4N7O/c1-13-4-3-9-32(17(13)12-29-21-27-10-15(11-28-21)22(24,25)26)20(34)18-16(33-30-7-8-31-33)6-5-14(2)19(18)23/h5-8,10-11,13,17H,3-4,9,12H2,1-2H3,(H,27,28,29)/t13-,17-/m1/s1	FFFVPJLBIWZFGE-CXAGYDPISA-N	373509	(2-fluoro-3-methyl-6-(2H-1,2,3-triazol-2-yl)phenyl)((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidin-1-yl)methanone::US9896452, Ex. A319	Orexin/Hypocretin receptor type 1	Homo sapiens		 6.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373509	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373509&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728338	404342597							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741494	C[C@@H]1CCCN([C@@H]1CNc1ncc(cn1)C(F)(F)F)C(=O)c1c(F)c(C)ccc1-n1nccn1	InChI=1S/C22H23F4N7O/c1-13-4-3-9-32(17(13)12-29-21-27-10-15(11-28-21)22(24,25)26)20(34)18-16(33-30-7-8-31-33)6-5-14(2)19(18)23/h5-8,10-11,13,17H,3-4,9,12H2,1-2H3,(H,27,28,29)/t13-,17-/m1/s1	FFFVPJLBIWZFGE-CXAGYDPISA-N	373509	(2-fluoro-3-methyl-6-(2H-1,2,3-triazol-2-yl)phenyl)((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidin-1-yl)methanone::US9896452, Ex. A319	Orexin receptor type 2	Homo sapiens		 4500							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373509	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373509&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117728338	404342597							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741495	C[C@@H]1CCCN([C@@H]1CNc1ncc(cn1)C(F)(F)F)C(=O)c1cc(ccc1-n1nccn1)C#N	InChI=1S/C22H21F3N8O/c1-14-3-2-8-32(19(14)13-29-21-27-11-16(12-28-21)22(23,24)25)20(34)17-9-15(10-26)4-5-18(17)33-30-6-7-31-33/h4-7,9,11-12,14,19H,2-3,8,13H2,1H3,(H,27,28,29)/t14-,19-/m1/s1	ASJLBZRMIFYLQQ-AUUYWEPGSA-N	373510	3-((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidine-1-carbonyl)-4-(2H-1,2,3-triazol-2-yl)benzonitrile::US9896452, Ex. A322	Orexin/Hypocretin receptor type 1	Homo sapiens		 11.0							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373510	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373510&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727934	404342598							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741496	C[C@@H]1CCCN([C@@H]1CNc1ncc(cn1)C(F)(F)F)C(=O)c1cc(ccc1-n1nccn1)C#N	InChI=1S/C22H21F3N8O/c1-14-3-2-8-32(19(14)13-29-21-27-11-16(12-28-21)22(23,24)25)20(34)17-9-15(10-26)4-5-18(17)33-30-6-7-31-33/h4-7,9,11-12,14,19H,2-3,8,13H2,1H3,(H,27,28,29)/t14-,19-/m1/s1	ASJLBZRMIFYLQQ-AUUYWEPGSA-N	373510	3-((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidine-1-carbonyl)-4-(2H-1,2,3-triazol-2-yl)benzonitrile::US9896452, Ex. A322	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373510	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373510&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727934	404342598							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741497	C[C@@H]1CCCN([C@@H]1CNc1ncc(cn1)C(F)(F)F)C(=O)c1cc(ccc1-c1ncccn1)C#N	InChI=1S/C24H22F3N7O/c1-15-4-2-9-34(20(15)14-33-23-31-12-17(13-32-23)24(25,26)27)22(35)19-10-16(11-28)5-6-18(19)21-29-7-3-8-30-21/h3,5-8,10,12-13,15,20H,2,4,9,14H2,1H3,(H,31,32,33)/t15-,20-/m1/s1	XQLMRBHDVDZUPQ-FOIQADDNSA-N	373511	3-((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidine-1-carbonyl)-4-(pyrimidin-2-yl)benzonitrile::US9896452, Ex. A323	Orexin/Hypocretin receptor type 1	Homo sapiens		 10.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373511	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373511&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728399	404342599							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741498	C[C@@H]1CCCN([C@@H]1CNc1ncc(cn1)C(F)(F)F)C(=O)c1cc(ccc1-c1ncccn1)C#N	InChI=1S/C24H22F3N7O/c1-15-4-2-9-34(20(15)14-33-23-31-12-17(13-32-23)24(25,26)27)22(35)19-10-16(11-28)5-6-18(19)21-29-7-3-8-30-21/h3,5-8,10,12-13,15,20H,2,4,9,14H2,1H3,(H,31,32,33)/t15-,20-/m1/s1	XQLMRBHDVDZUPQ-FOIQADDNSA-N	373511	3-((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidine-1-carbonyl)-4-(pyrimidin-2-yl)benzonitrile::US9896452, Ex. A323	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373511	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373511&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117728399	404342599							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741499	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1c(F)c(F)ccc1-n1nccn1	InChI=1S/C22H21F5N6O/c1-13-3-2-10-32(17(13)12-29-18-7-4-14(11-28-18)22(25,26)27)21(34)19-16(33-30-8-9-31-33)6-5-15(23)20(19)24/h4-9,11,13,17H,2-3,10,12H2,1H3,(H,28,29)/t13-,17-/m1/s1	OIRHLGBHOQKBJU-CXAGYDPISA-N	373512	(2,3-difluoro-6-(2H-1,2,3-triazol-2-yl)phenyl)((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)methanone::US9896452, Ex. A336	Orexin/Hypocretin receptor type 1	Homo sapiens		 10.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373512	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373512&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727801	404342600							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741500	C[C@@H]1CCCN([C@@H]1CNc1ccc(cn1)C(F)(F)F)C(=O)c1c(F)c(F)ccc1-n1nccn1	InChI=1S/C22H21F5N6O/c1-13-3-2-10-32(17(13)12-29-18-7-4-14(11-28-18)22(25,26)27)21(34)19-16(33-30-8-9-31-33)6-5-15(23)20(19)24/h4-9,11,13,17H,2-3,10,12H2,1H3,(H,28,29)/t13-,17-/m1/s1	OIRHLGBHOQKBJU-CXAGYDPISA-N	373512	(2,3-difluoro-6-(2H-1,2,3-triazol-2-yl)phenyl)((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)methanone::US9896452, Ex. A336	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373512	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373512&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727801	404342600							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741501	C[C@@H]1CCCN([C@@H]1CNc1ncc(cn1)C(F)(F)F)C(=O)c1c(F)c(F)ccc1-n1nccn1	InChI=1S/C21H20F5N7O/c1-12-3-2-8-32(16(12)11-29-20-27-9-13(10-28-20)21(24,25)26)19(34)17-15(33-30-6-7-31-33)5-4-14(22)18(17)23/h4-7,9-10,12,16H,2-3,8,11H2,1H3,(H,27,28,29)/t12-,16-/m1/s1	VREVCPBFCGTIGW-MLGOLLRUSA-N	373513	(2,3-difluoro-6-(2H-1,2,3-triazol-2-yl)phenyl)((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidin-1-yl)methanone::US9896452, Ex. A337	Orexin/Hypocretin receptor type 1	Homo sapiens		 9.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373513	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373513&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117728214	404342601							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741502	C[C@@H]1CCCN([C@@H]1CNc1ncc(cn1)C(F)(F)F)C(=O)c1c(F)c(F)ccc1-n1nccn1	InChI=1S/C21H20F5N7O/c1-12-3-2-8-32(16(12)11-29-20-27-9-13(10-28-20)21(24,25)26)19(34)17-15(33-30-6-7-31-33)5-4-14(22)18(17)23/h4-7,9-10,12,16H,2-3,8,11H2,1H3,(H,27,28,29)/t12-,16-/m1/s1	VREVCPBFCGTIGW-MLGOLLRUSA-N	373513	(2,3-difluoro-6-(2H-1,2,3-triazol-2-yl)phenyl)((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidin-1-yl)methanone::US9896452, Ex. A337	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373513	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373513&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117728214	404342601							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741503	COc1ccc(c(C(=O)N2CCC[C@@H](C)[C@H]2CNc2ccc(cn2)C(F)(F)F)c1F)-n1nccn1	InChI=1S/C23H24F4N6O2/c1-14-4-3-11-32(17(14)13-29-19-8-5-15(12-28-19)23(25,26)27)22(34)20-16(33-30-9-10-31-33)6-7-18(35-2)21(20)24/h5-10,12,14,17H,3-4,11,13H2,1-2H3,(H,28,29)/t14-,17-/m1/s1	NMRYDMKXCPNLQL-RHSMWYFYSA-N	373514	(2-fluoro-3-methoxy-6-(2H-1,2,3-triazol-2-yl)phenyl)((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)methanone::US9896452, Ex. A338	Orexin/Hypocretin receptor type 1	Homo sapiens		<10.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373514	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373514&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727939	404342602							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741504	COc1ccc(c(C(=O)N2CCC[C@@H](C)[C@H]2CNc2ccc(cn2)C(F)(F)F)c1F)-n1nccn1	InChI=1S/C23H24F4N6O2/c1-14-4-3-11-32(17(14)13-29-19-8-5-15(12-28-19)23(25,26)27)22(34)20-16(33-30-9-10-31-33)6-7-18(35-2)21(20)24/h5-10,12,14,17H,3-4,11,13H2,1-2H3,(H,28,29)/t14-,17-/m1/s1	NMRYDMKXCPNLQL-RHSMWYFYSA-N	373514	(2-fluoro-3-methoxy-6-(2H-1,2,3-triazol-2-yl)phenyl)((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)methanone::US9896452, Ex. A338	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373514	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373514&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727939	404342602							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741505	COc1ccc(c(C(=O)N2CCC[C@@H](C)[C@H]2CNc2ncc(cn2)C(F)(F)F)c1F)-n1nccn1	InChI=1S/C22H23F4N7O2/c1-13-4-3-9-32(16(13)12-29-21-27-10-14(11-28-21)22(24,25)26)20(34)18-15(33-30-7-8-31-33)5-6-17(35-2)19(18)23/h5-8,10-11,13,16H,3-4,9,12H2,1-2H3,(H,27,28,29)/t13-,16-/m1/s1	JMJCURBMHAZGQL-CZUORRHYSA-N	373515	(2-fluoro-3-methoxy-6-(2H-1,2,3-triazol-2-yl)phenyl)((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidin-1-yl)methanone::US9896452, Ex. A339	Orexin/Hypocretin receptor type 1	Homo sapiens		 5.00							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373515	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5448&target=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373515&enzyme=Orexin%2FHypocretin+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search			117727859	404342603							1	MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP	4ZJ8,4ZJC	Orexin/Hypocretin receptor type 1	OX1R_HUMAN	O43613	A8K3A6 Q9HBV6																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
741506	COc1ccc(c(C(=O)N2CCC[C@@H](C)[C@H]2CNc2ncc(cn2)C(F)(F)F)c1F)-n1nccn1	InChI=1S/C22H23F4N7O2/c1-13-4-3-9-32(16(13)12-29-21-27-10-14(11-28-21)22(24,25)26)20(34)18-15(33-30-7-8-31-33)5-6-17(35-2)19(18)23/h5-8,10-11,13,16H,3-4,9,12H2,1-2H3,(H,27,28,29)/t13-,16-/m1/s1	JMJCURBMHAZGQL-CZUORRHYSA-N	373515	(2-fluoro-3-methoxy-6-(2H-1,2,3-triazol-2-yl)phenyl)((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidin-1-yl)methanone::US9896452, Ex. A339	Orexin receptor type 2	Homo sapiens		>5000							US Patent		10.7270/Q22J6F5N		aid1798225	US9896452	Kamenecka, TM; He, Y; Nguyen, W; Jiang, R; Song, X; Herr, RJ; Jiang, Q	2/20/2018	1/21/2020	EOLAS THERAPEUTICS, INC.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=373515	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5447&target=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=373515&enzyme=Orexin+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search			117727859	404342603							1	MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW	4S0V,5WQC,5WS3	Orexin receptor type 2	OX2R_HUMAN	O43614	Q5VTM0