BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Date of publication Date in BindingDB Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID PubChem SID ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence 1 PDB ID(s) of Target Chain 1 UniProt (SwissProt) Recommended Name of Target Chain 1 UniProt (SwissProt) Entry Name of Target Chain 1 UniProt (SwissProt) Primary ID of Target Chain 1 UniProt (SwissProt) Secondary ID(s) of Target Chain 1 UniProt (SwissProt) Alternative ID(s) of Target Chain 1 UniProt (TrEMBL) Submitted Name of Target Chain 1 UniProt (TrEMBL) Entry Name of Target Chain 1 UniProt (TrEMBL) Primary ID of Target Chain 1 UniProt (TrEMBL) Secondary ID(s) of Target Chain 1 UniProt (TrEMBL) Alternative ID(s) of Target Chain 1 BindingDB Target Chain Sequence 2 PDB ID(s) of Target Chain 2 UniProt (SwissProt) Recommended Name of Target Chain 2 UniProt (SwissProt) Entry Name of Target Chain 2 UniProt (SwissProt) Primary ID of Target Chain 2 UniProt (SwissProt) Secondary ID(s) of Target Chain 2 UniProt (SwissProt) Alternative ID(s) of Target Chain 2 UniProt (TrEMBL) Submitted Name of Target Chain 2 UniProt (TrEMBL) Entry Name of Target Chain 2 UniProt (TrEMBL) Primary ID of Target Chain 2 UniProt (TrEMBL) Secondary ID(s) of Target Chain 2 UniProt (TrEMBL) Alternative ID(s) of Target Chain 2 BindingDB Target Chain Sequence 3 PDB ID(s) of Target Chain 3 UniProt (SwissProt) Recommended Name of Target Chain 3 UniProt (SwissProt) Entry Name of Target Chain 3 UniProt (SwissProt) Primary ID of Target Chain 3 UniProt (SwissProt) Secondary ID(s) of Target Chain 3 UniProt (SwissProt) Alternative ID(s) of Target Chain 3 UniProt (TrEMBL) Submitted Name of Target Chain 3 UniProt (TrEMBL) Entry Name of Target Chain 3 UniProt (TrEMBL) Primary ID of Target Chain 3 UniProt (TrEMBL) Secondary ID(s) of Target Chain 3 UniProt (TrEMBL) Alternative ID(s) of Target Chain 3 BindingDB Target Chain Sequence 4 PDB ID(s) of Target Chain 4 UniProt (SwissProt) Recommended Name of Target Chain 4 UniProt (SwissProt) Entry Name of Target Chain 4 UniProt (SwissProt) Primary ID of Target Chain 4 UniProt (SwissProt) Secondary ID(s) of Target Chain 4 UniProt (SwissProt) Alternative ID(s) of Target Chain 4 UniProt (TrEMBL) Submitted Name of Target Chain 4 UniProt (TrEMBL) Entry Name of Target Chain 4 UniProt (TrEMBL) Primary ID of Target Chain 4 UniProt (TrEMBL) Secondary ID(s) of Target Chain 4 UniProt (TrEMBL) Alternative ID(s) of Target Chain 4 BindingDB Target Chain Sequence 5 PDB ID(s) of Target Chain 5 UniProt (SwissProt) Recommended Name of Target Chain 5 UniProt (SwissProt) Entry Name of Target Chain 5 UniProt (SwissProt) Primary ID of Target Chain 5 UniProt (SwissProt) Secondary ID(s) of Target Chain 5 UniProt (SwissProt) Alternative ID(s) of Target Chain 5 UniProt (TrEMBL) Submitted Name of Target Chain 5 UniProt (TrEMBL) Entry Name of Target Chain 5 UniProt (TrEMBL) Primary ID of Target Chain 5 UniProt (TrEMBL) Secondary ID(s) of Target Chain 5 UniProt (TrEMBL) Alternative ID(s) of Target Chain 5 BindingDB Target Chain Sequence 6 PDB ID(s) of Target Chain 6 UniProt (SwissProt) Recommended Name of Target Chain 6 UniProt (SwissProt) Entry Name of Target Chain 6 UniProt (SwissProt) Primary ID of Target Chain 6 UniProt (SwissProt) Secondary ID(s) of Target Chain 6 UniProt (SwissProt) Alternative ID(s) of Target Chain 6 UniProt (TrEMBL) Submitted Name of Target Chain 6 UniProt (TrEMBL) Entry Name of Target Chain 6 UniProt (TrEMBL) Primary ID of Target Chain 6 UniProt (TrEMBL) Secondary ID(s) of Target Chain 6 UniProt (TrEMBL) Alternative ID(s) of Target Chain 6 BindingDB Target Chain Sequence 7 PDB ID(s) of Target Chain 7 UniProt (SwissProt) Recommended Name of Target Chain 7 UniProt (SwissProt) Entry Name of Target Chain 7 UniProt (SwissProt) Primary ID of Target Chain 7 UniProt (SwissProt) Secondary ID(s) of Target Chain 7 UniProt (SwissProt) Alternative ID(s) of Target Chain 7 UniProt (TrEMBL) Submitted Name of Target Chain 7 UniProt (TrEMBL) Entry Name of Target Chain 7 UniProt (TrEMBL) Primary ID of Target Chain 7 UniProt (TrEMBL) Secondary ID(s) of Target Chain 7 UniProt (TrEMBL) Alternative ID(s) of Target Chain 7 BindingDB Target Chain Sequence 8 PDB ID(s) of Target Chain 8 UniProt (SwissProt) Recommended Name of Target Chain 8 UniProt (SwissProt) Entry Name of Target Chain 8 UniProt (SwissProt) Primary ID of Target Chain 8 UniProt (SwissProt) Secondary ID(s) of Target Chain 8 UniProt (SwissProt) Alternative ID(s) of Target Chain 8 UniProt (TrEMBL) Submitted Name of Target Chain 8 UniProt (TrEMBL) Entry Name of Target Chain 8 UniProt (TrEMBL) Primary ID of Target Chain 8 UniProt (TrEMBL) Secondary ID(s) of Target Chain 8 UniProt (TrEMBL) Alternative ID(s) of Target Chain 8 BindingDB Target Chain Sequence 9 PDB ID(s) of Target Chain 9 UniProt (SwissProt) Recommended Name of Target Chain 9 UniProt (SwissProt) Entry Name of Target Chain 9 UniProt (SwissProt) Primary ID of Target Chain 9 UniProt (SwissProt) Secondary ID(s) of Target Chain 9 UniProt (SwissProt) Alternative ID(s) of Target Chain 9 UniProt (TrEMBL) Submitted Name of Target Chain 9 UniProt (TrEMBL) Entry Name of Target Chain 9 UniProt (TrEMBL) Primary ID of Target Chain 9 UniProt (TrEMBL) Secondary ID(s) of Target Chain 9 UniProt (TrEMBL) Alternative ID(s) of Target Chain 9 BindingDB Target Chain Sequence 10 PDB ID(s) of Target Chain 10 UniProt (SwissProt) Recommended Name of Target Chain 10 UniProt (SwissProt) Entry Name of Target Chain 10 UniProt (SwissProt) Primary ID of Target Chain 10 UniProt (SwissProt) Secondary ID(s) of Target Chain 10 UniProt (SwissProt) Alternative ID(s) of Target Chain 10 UniProt (TrEMBL) Submitted Name of Target Chain 10 UniProt (TrEMBL) Entry Name of Target Chain 10 UniProt (TrEMBL) Primary ID of Target Chain 10 UniProt (TrEMBL) Secondary ID(s) of Target Chain 10 UniProt (TrEMBL) Alternative ID(s) of Target Chain 10 BindingDB Target Chain Sequence 11 PDB ID(s) of Target Chain 11 UniProt (SwissProt) Recommended Name of Target Chain 11 UniProt (SwissProt) Entry Name of Target Chain 11 UniProt (SwissProt) Primary ID of Target Chain 11 UniProt (SwissProt) Secondary ID(s) of Target Chain 11 UniProt (SwissProt) Alternative ID(s) of Target Chain 11 UniProt (TrEMBL) Submitted Name of Target Chain 11 UniProt (TrEMBL) Entry Name of Target Chain 11 UniProt (TrEMBL) Primary ID of Target Chain 11 UniProt (TrEMBL) Secondary ID(s) of Target Chain 11 UniProt (TrEMBL) Alternative ID(s) of Target Chain 11 BindingDB Target Chain Sequence 12 PDB ID(s) of Target Chain 12 UniProt (SwissProt) Recommended Name of Target Chain 12 UniProt (SwissProt) Entry Name of Target Chain 12 UniProt (SwissProt) Primary ID of Target Chain 12 UniProt (SwissProt) Secondary ID(s) of Target Chain 12 UniProt (SwissProt) Alternative ID(s) of Target Chain 12 UniProt (TrEMBL) Submitted Name of Target Chain 12 UniProt (TrEMBL) Entry Name of Target Chain 12 UniProt (TrEMBL) Primary ID of Target Chain 12 UniProt (TrEMBL) Secondary ID(s) of Target Chain 12 UniProt (TrEMBL) Alternative ID(s) of Target Chain 12 BindingDB Target Chain Sequence 13 PDB ID(s) of Target Chain 13 UniProt (SwissProt) Recommended Name of Target Chain 13 UniProt (SwissProt) Entry Name of Target Chain 13 UniProt (SwissProt) Primary ID of Target Chain 13 UniProt (SwissProt) Secondary ID(s) of Target Chain 13 UniProt (SwissProt) Alternative ID(s) of Target Chain 13 UniProt (TrEMBL) Submitted Name of Target Chain 13 UniProt (TrEMBL) Entry Name of Target Chain 13 UniProt (TrEMBL) Primary ID of Target Chain 13 UniProt (TrEMBL) Secondary ID(s) of Target Chain 13 UniProt (TrEMBL) Alternative ID(s) of Target Chain 13 BindingDB Target Chain Sequence 14 PDB ID(s) of Target Chain 14 UniProt (SwissProt) Recommended Name of Target Chain 14 UniProt (SwissProt) Entry Name of Target Chain 14 UniProt (SwissProt) Primary ID of Target Chain 14 UniProt (SwissProt) Secondary ID(s) of Target Chain 14 UniProt (SwissProt) Alternative ID(s) of Target Chain 14 UniProt (TrEMBL) Submitted Name of Target Chain 14 UniProt (TrEMBL) Entry Name of Target Chain 14 UniProt (TrEMBL) Primary ID of Target Chain 14 UniProt (TrEMBL) Secondary ID(s) of Target Chain 14 UniProt (TrEMBL) Alternative ID(s) of Target Chain 14 BindingDB Target Chain Sequence 15 PDB ID(s) of Target Chain 15 UniProt (SwissProt) Recommended Name of Target Chain 15 UniProt (SwissProt) Entry Name of Target Chain 15 UniProt (SwissProt) Primary ID of Target Chain 15 UniProt (SwissProt) Secondary ID(s) of Target Chain 15 UniProt (SwissProt) Alternative ID(s) of Target Chain 15 UniProt (TrEMBL) Submitted Name of Target Chain 15 UniProt (TrEMBL) Entry Name of Target Chain 15 UniProt (TrEMBL) Primary ID of Target Chain 15 UniProt (TrEMBL) Secondary ID(s) of Target Chain 15 UniProt (TrEMBL) Alternative ID(s) of Target Chain 15 BindingDB Target Chain Sequence 16 PDB ID(s) of Target Chain 16 UniProt (SwissProt) Recommended Name of Target Chain 16 UniProt (SwissProt) Entry Name of Target Chain 16 UniProt (SwissProt) Primary ID of Target Chain 16 UniProt (SwissProt) Secondary ID(s) of Target Chain 16 UniProt (SwissProt) Alternative ID(s) of Target Chain 16 UniProt (TrEMBL) Submitted Name of Target Chain 16 UniProt (TrEMBL) Entry Name of Target Chain 16 UniProt (TrEMBL) Primary ID of Target Chain 16 UniProt (TrEMBL) Secondary ID(s) of Target Chain 16 UniProt (TrEMBL) Alternative ID(s) of Target Chain 16 BindingDB Target Chain Sequence 17 PDB ID(s) of Target Chain 17 UniProt (SwissProt) Recommended Name of Target Chain 17 UniProt (SwissProt) Entry Name of Target Chain 17 UniProt (SwissProt) Primary ID of Target Chain 17 UniProt (SwissProt) Secondary ID(s) of Target Chain 17 UniProt (SwissProt) Alternative ID(s) of Target Chain 17 UniProt (TrEMBL) Submitted Name of Target Chain 17 UniProt (TrEMBL) Entry Name of Target Chain 17 UniProt (TrEMBL) Primary ID of Target Chain 17 UniProt (TrEMBL) Secondary ID(s) of Target Chain 17 UniProt (TrEMBL) Alternative ID(s) of Target Chain 17 BindingDB Target Chain Sequence 18 PDB ID(s) of Target Chain 18 UniProt (SwissProt) Recommended Name of Target Chain 18 UniProt (SwissProt) Entry Name of Target Chain 18 UniProt (SwissProt) Primary ID of Target Chain 18 UniProt (SwissProt) Secondary ID(s) of Target Chain 18 UniProt (SwissProt) Alternative ID(s) of Target Chain 18 UniProt (TrEMBL) Submitted Name of Target Chain 18 UniProt (TrEMBL) Entry Name of Target Chain 18 UniProt (TrEMBL) Primary ID of Target Chain 18 UniProt (TrEMBL) Secondary ID(s) of Target Chain 18 UniProt (TrEMBL) Alternative ID(s) of Target Chain 18 BindingDB Target Chain Sequence 19 PDB ID(s) of Target Chain 19 UniProt (SwissProt) Recommended Name of Target Chain 19 UniProt (SwissProt) Entry Name of Target Chain 19 UniProt (SwissProt) Primary ID of Target Chain 19 UniProt (SwissProt) Secondary ID(s) of Target Chain 19 UniProt (SwissProt) Alternative ID(s) of Target Chain 19 UniProt (TrEMBL) Submitted Name of Target Chain 19 UniProt (TrEMBL) Entry Name of Target Chain 19 UniProt (TrEMBL) Primary ID of Target Chain 19 UniProt (TrEMBL) Secondary ID(s) of Target Chain 19 UniProt (TrEMBL) Alternative ID(s) of Target Chain 19 BindingDB Target Chain Sequence 20 PDB ID(s) of Target Chain 20 UniProt (SwissProt) Recommended Name of Target Chain 20 UniProt (SwissProt) Entry Name of Target Chain 20 UniProt (SwissProt) Primary ID of Target Chain 20 UniProt (SwissProt) Secondary ID(s) of Target Chain 20 UniProt (SwissProt) Alternative ID(s) of Target Chain 20 UniProt (TrEMBL) Submitted Name of Target Chain 20 UniProt (TrEMBL) Entry Name of Target Chain 20 UniProt (TrEMBL) Primary ID of Target Chain 20 UniProt (TrEMBL) Secondary ID(s) of Target Chain 20 UniProt (TrEMBL) Alternative ID(s) of Target Chain 20 BindingDB Target Chain Sequence 21 PDB ID(s) of Target Chain 21 UniProt (SwissProt) Recommended Name of Target Chain 21 UniProt (SwissProt) Entry Name of Target Chain 21 UniProt (SwissProt) Primary ID of Target Chain 21 UniProt (SwissProt) Secondary ID(s) of Target Chain 21 UniProt (SwissProt) Alternative ID(s) of Target Chain 21 UniProt (TrEMBL) Submitted Name of Target Chain 21 UniProt (TrEMBL) Entry Name of Target Chain 21 UniProt (TrEMBL) Primary ID of Target Chain 21 UniProt (TrEMBL) Secondary ID(s) of Target Chain 21 UniProt (TrEMBL) Alternative ID(s) of Target Chain 21 BindingDB Target Chain Sequence 22 PDB ID(s) of Target Chain 22 UniProt (SwissProt) Recommended Name of Target Chain 22 UniProt (SwissProt) Entry Name of Target Chain 22 UniProt (SwissProt) Primary ID of Target Chain 22 UniProt (SwissProt) Secondary ID(s) of Target Chain 22 UniProt (SwissProt) Alternative ID(s) of Target Chain 22 UniProt (TrEMBL) Submitted Name of Target Chain 22 UniProt (TrEMBL) Entry Name of Target Chain 22 UniProt (TrEMBL) Primary ID of Target Chain 22 UniProt (TrEMBL) Secondary ID(s) of Target Chain 22 UniProt (TrEMBL) Alternative ID(s) of Target Chain 22 BindingDB Target Chain Sequence 23 PDB ID(s) of Target Chain 23 UniProt (SwissProt) Recommended Name of Target Chain 23 UniProt (SwissProt) Entry Name of Target Chain 23 UniProt (SwissProt) Primary ID of Target Chain 23 UniProt (SwissProt) Secondary ID(s) of Target Chain 23 UniProt (SwissProt) Alternative ID(s) of Target Chain 23 UniProt (TrEMBL) Submitted Name of Target Chain 23 UniProt (TrEMBL) Entry Name of Target Chain 23 UniProt (TrEMBL) Primary ID of Target Chain 23 UniProt (TrEMBL) Secondary ID(s) of Target Chain 23 UniProt (TrEMBL) Alternative ID(s) of Target Chain 23 BindingDB Target Chain Sequence 24 PDB ID(s) of Target Chain 24 UniProt (SwissProt) Recommended Name of Target Chain 24 UniProt (SwissProt) Entry Name of Target Chain 24 UniProt (SwissProt) Primary ID of Target Chain 24 UniProt (SwissProt) Secondary ID(s) of Target Chain 24 UniProt (SwissProt) Alternative ID(s) of Target Chain 24 UniProt (TrEMBL) Submitted Name of Target Chain 24 UniProt (TrEMBL) Entry Name of Target Chain 24 UniProt (TrEMBL) Primary ID of Target Chain 24 UniProt (TrEMBL) Secondary ID(s) of Target Chain 24 UniProt (TrEMBL) Alternative ID(s) of Target Chain 24 BindingDB Target Chain Sequence 25 PDB ID(s) of Target Chain 25 UniProt (SwissProt) Recommended Name of Target Chain 25 UniProt (SwissProt) Entry Name of Target Chain 25 UniProt (SwissProt) Primary ID of Target Chain 25 UniProt (SwissProt) Secondary ID(s) of Target Chain 25 UniProt (SwissProt) Alternative ID(s) of Target Chain 25 UniProt (TrEMBL) Submitted Name of Target Chain 25 UniProt (TrEMBL) Entry Name of Target Chain 25 UniProt (TrEMBL) Primary ID of Target Chain 25 UniProt (TrEMBL) Secondary ID(s) of Target Chain 25 UniProt (TrEMBL) Alternative ID(s) of Target Chain 25 BindingDB Target Chain Sequence 26 PDB ID(s) of Target Chain 26 UniProt (SwissProt) Recommended Name of Target Chain 26 UniProt (SwissProt) Entry Name of Target Chain 26 UniProt (SwissProt) Primary ID of Target Chain 26 UniProt (SwissProt) Secondary ID(s) of Target Chain 26 UniProt (SwissProt) Alternative ID(s) of Target Chain 26 UniProt (TrEMBL) Submitted Name of Target Chain 26 UniProt (TrEMBL) Entry Name of Target Chain 26 UniProt (TrEMBL) Primary ID of Target Chain 26 UniProt (TrEMBL) Secondary ID(s) of Target Chain 26 UniProt (TrEMBL) Alternative ID(s) of Target Chain 26 BindingDB Target Chain Sequence 27 PDB ID(s) of Target Chain 27 UniProt (SwissProt) Recommended Name of Target Chain 27 UniProt (SwissProt) Entry Name of Target Chain 27 UniProt (SwissProt) Primary ID of Target Chain 27 UniProt (SwissProt) Secondary ID(s) of Target Chain 27 UniProt (SwissProt) Alternative ID(s) of Target Chain 27 UniProt (TrEMBL) Submitted Name of Target Chain 27 UniProt (TrEMBL) Entry Name of Target Chain 27 UniProt (TrEMBL) Primary ID of Target Chain 27 UniProt (TrEMBL) Secondary ID(s) of Target Chain 27 UniProt (TrEMBL) Alternative ID(s) of Target Chain 27 BindingDB Target Chain Sequence 28 PDB ID(s) of Target Chain 28 UniProt (SwissProt) Recommended Name of Target Chain 28 UniProt (SwissProt) Entry Name of Target Chain 28 UniProt (SwissProt) Primary ID of Target Chain 28 UniProt (SwissProt) Secondary ID(s) of Target Chain 28 UniProt (SwissProt) Alternative ID(s) of Target Chain 28 UniProt (TrEMBL) Submitted Name of Target Chain 28 UniProt (TrEMBL) Entry Name of Target Chain 28 UniProt (TrEMBL) Primary ID of Target Chain 28 UniProt (TrEMBL) Secondary ID(s) of Target Chain 28 UniProt (TrEMBL) Alternative ID(s) of Target Chain 28 BindingDB Target Chain Sequence 29 PDB ID(s) of Target Chain 29 UniProt (SwissProt) Recommended Name of Target Chain 29 UniProt (SwissProt) Entry Name of Target Chain 29 UniProt (SwissProt) Primary ID of Target Chain 29 UniProt (SwissProt) Secondary ID(s) of Target Chain 29 UniProt (SwissProt) Alternative ID(s) of Target Chain 29 UniProt (TrEMBL) Submitted Name of Target Chain 29 UniProt (TrEMBL) Entry Name of Target Chain 29 UniProt (TrEMBL) Primary ID of Target Chain 29 UniProt (TrEMBL) Secondary ID(s) of Target Chain 29 UniProt (TrEMBL) Alternative ID(s) of Target Chain 29 BindingDB Target Chain Sequence 30 PDB ID(s) of Target Chain 30 UniProt (SwissProt) Recommended Name of Target Chain 30 UniProt (SwissProt) Entry Name of Target Chain 30 UniProt (SwissProt) Primary ID of Target Chain 30 UniProt (SwissProt) Secondary ID(s) of Target Chain 30 UniProt (SwissProt) Alternative ID(s) of Target Chain 30 UniProt (TrEMBL) Submitted Name of Target Chain 30 UniProt (TrEMBL) Entry Name of Target Chain 30 UniProt (TrEMBL) Primary ID of Target Chain 30 UniProt (TrEMBL) Secondary ID(s) of Target Chain 30 UniProt (TrEMBL) Alternative ID(s) of Target Chain 30 BindingDB Target Chain Sequence 31 PDB ID(s) of Target Chain 31 UniProt (SwissProt) Recommended Name of Target Chain 31 UniProt (SwissProt) Entry Name of Target Chain 31 UniProt (SwissProt) Primary ID of Target Chain 31 UniProt (SwissProt) Secondary ID(s) of Target Chain 31 UniProt (SwissProt) Alternative ID(s) of Target Chain 31 UniProt (TrEMBL) Submitted Name of Target Chain 31 UniProt (TrEMBL) Entry Name of Target Chain 31 UniProt (TrEMBL) Primary ID of Target Chain 31 UniProt (TrEMBL) Secondary ID(s) of Target Chain 31 UniProt (TrEMBL) Alternative ID(s) of Target Chain 31 BindingDB Target Chain Sequence 32 PDB ID(s) of Target Chain 32 UniProt (SwissProt) Recommended Name of Target Chain 32 UniProt (SwissProt) Entry Name of Target Chain 32 UniProt (SwissProt) Primary ID of Target Chain 32 UniProt (SwissProt) Secondary ID(s) of Target Chain 32 UniProt (SwissProt) Alternative ID(s) of Target Chain 32 UniProt (TrEMBL) Submitted Name of Target Chain 32 UniProt (TrEMBL) Entry Name of Target Chain 32 UniProt (TrEMBL) Primary ID of Target Chain 32 UniProt (TrEMBL) Secondary ID(s) of Target Chain 32 UniProt (TrEMBL) Alternative ID(s) of Target Chain 32 BindingDB Target Chain Sequence 33 PDB ID(s) of Target Chain 33 UniProt (SwissProt) Recommended Name of Target Chain 33 UniProt (SwissProt) Entry Name of Target Chain 33 UniProt (SwissProt) Primary ID of Target Chain 33 UniProt (SwissProt) Secondary ID(s) of Target Chain 33 UniProt (SwissProt) Alternative ID(s) of Target Chain 33 UniProt (TrEMBL) Submitted Name of Target Chain 33 UniProt (TrEMBL) Entry Name of Target Chain 33 UniProt (TrEMBL) Primary ID of Target Chain 33 UniProt (TrEMBL) Secondary ID(s) of Target Chain 33 UniProt (TrEMBL) Alternative ID(s) of Target Chain 33 BindingDB Target Chain Sequence 34 PDB ID(s) of Target Chain 34 UniProt (SwissProt) Recommended Name of Target Chain 34 UniProt (SwissProt) Entry Name of Target Chain 34 UniProt (SwissProt) Primary ID of Target Chain 34 UniProt (SwissProt) Secondary ID(s) of Target Chain 34 UniProt (SwissProt) Alternative ID(s) of Target Chain 34 UniProt (TrEMBL) Submitted Name of Target Chain 34 UniProt (TrEMBL) Entry Name of Target Chain 34 UniProt (TrEMBL) Primary ID of Target Chain 34 UniProt (TrEMBL) Secondary ID(s) of Target Chain 34 UniProt (TrEMBL) Alternative ID(s) of Target Chain 34 BindingDB Target Chain Sequence 35 PDB ID(s) of Target Chain 35 UniProt (SwissProt) Recommended Name of Target Chain 35 UniProt (SwissProt) Entry Name of Target Chain 35 UniProt (SwissProt) Primary ID of Target Chain 35 UniProt (SwissProt) Secondary ID(s) of Target Chain 35 UniProt (SwissProt) Alternative ID(s) of Target Chain 35 UniProt (TrEMBL) Submitted Name of Target Chain 35 UniProt (TrEMBL) Entry Name of Target Chain 35 UniProt (TrEMBL) Primary ID of Target Chain 35 UniProt (TrEMBL) Secondary ID(s) of Target Chain 35 UniProt (TrEMBL) Alternative ID(s) of Target Chain 35 BindingDB Target Chain Sequence 36 PDB ID(s) of Target Chain 36 UniProt (SwissProt) Recommended Name of Target Chain 36 UniProt (SwissProt) Entry Name of Target Chain 36 UniProt (SwissProt) Primary ID of Target Chain 36 UniProt (SwissProt) Secondary ID(s) of Target Chain 36 UniProt (SwissProt) Alternative ID(s) of Target Chain 36 UniProt (TrEMBL) Submitted Name of Target Chain 36 UniProt (TrEMBL) Entry Name of Target Chain 36 UniProt (TrEMBL) Primary ID of Target Chain 36 UniProt (TrEMBL) Secondary ID(s) of Target Chain 36 UniProt (TrEMBL) Alternative ID(s) of Target Chain 36 BindingDB Target Chain Sequence 37 PDB ID(s) of Target Chain 37 UniProt (SwissProt) Recommended Name of Target Chain 37 UniProt (SwissProt) Entry Name of Target Chain 37 UniProt (SwissProt) Primary ID of Target Chain 37 UniProt (SwissProt) Secondary ID(s) of Target Chain 37 UniProt (SwissProt) Alternative ID(s) of Target Chain 37 UniProt (TrEMBL) Submitted Name of Target Chain 37 UniProt (TrEMBL) Entry Name of Target Chain 37 UniProt (TrEMBL) Primary ID of Target Chain 37 UniProt (TrEMBL) Secondary ID(s) of Target Chain 37 UniProt (TrEMBL) Alternative ID(s) of Target Chain 37 BindingDB Target Chain Sequence 38 PDB ID(s) of Target Chain 38 UniProt (SwissProt) Recommended Name of Target Chain 38 UniProt (SwissProt) Entry Name of Target Chain 38 UniProt (SwissProt) Primary ID of Target Chain 38 UniProt (SwissProt) Secondary ID(s) of Target Chain 38 UniProt (SwissProt) Alternative ID(s) of Target Chain 38 UniProt (TrEMBL) Submitted Name of Target Chain 38 UniProt (TrEMBL) Entry Name of Target Chain 38 UniProt (TrEMBL) Primary ID of Target Chain 38 UniProt (TrEMBL) Secondary ID(s) of Target Chain 38 UniProt (TrEMBL) Alternative ID(s) of Target Chain 38 BindingDB Target Chain Sequence 39 PDB ID(s) of Target Chain 39 UniProt (SwissProt) Recommended Name of Target Chain 39 UniProt (SwissProt) Entry Name of Target Chain 39 UniProt (SwissProt) Primary ID of Target Chain 39 UniProt (SwissProt) Secondary ID(s) of Target Chain 39 UniProt (SwissProt) Alternative ID(s) of Target Chain 39 UniProt (TrEMBL) Submitted Name of Target Chain 39 UniProt (TrEMBL) Entry Name of Target Chain 39 UniProt (TrEMBL) Primary ID of Target Chain 39 UniProt (TrEMBL) Secondary ID(s) of Target Chain 39 UniProt (TrEMBL) Alternative ID(s) of Target Chain 39 BindingDB Target Chain Sequence 40 PDB ID(s) of Target Chain 40 UniProt (SwissProt) Recommended Name of Target Chain 40 UniProt (SwissProt) Entry Name of Target Chain 40 UniProt (SwissProt) Primary ID of Target Chain 40 UniProt (SwissProt) Secondary ID(s) of Target Chain 40 UniProt (SwissProt) Alternative ID(s) of Target Chain 40 UniProt (TrEMBL) Submitted Name of Target Chain 40 UniProt (TrEMBL) Entry Name of Target Chain 40 UniProt (TrEMBL) Primary ID of Target Chain 40 UniProt (TrEMBL) Secondary ID(s) of Target Chain 40 UniProt (TrEMBL) Alternative ID(s) of Target Chain 40 BindingDB Target Chain Sequence 41 PDB ID(s) of Target Chain 41 UniProt (SwissProt) Recommended Name of Target Chain 41 UniProt (SwissProt) Entry Name of Target Chain 41 UniProt (SwissProt) Primary ID of Target Chain 41 UniProt (SwissProt) Secondary ID(s) of Target Chain 41 UniProt (SwissProt) Alternative ID(s) of Target Chain 41 UniProt (TrEMBL) Submitted Name of Target Chain 41 UniProt (TrEMBL) Entry Name of Target Chain 41 UniProt (TrEMBL) Primary ID of Target Chain 41 UniProt (TrEMBL) Secondary ID(s) of Target Chain 41 UniProt (TrEMBL) Alternative ID(s) of Target Chain 41 BindingDB Target Chain Sequence 42 PDB ID(s) of Target Chain 42 UniProt (SwissProt) Recommended Name of Target Chain 42 UniProt (SwissProt) Entry Name of Target Chain 42 UniProt (SwissProt) Primary ID of Target Chain 42 UniProt (SwissProt) Secondary ID(s) of Target Chain 42 UniProt (SwissProt) Alternative ID(s) of Target Chain 42 UniProt (TrEMBL) Submitted Name of Target Chain 42 UniProt (TrEMBL) Entry Name of Target Chain 42 UniProt (TrEMBL) Primary ID of Target Chain 42 UniProt (TrEMBL) Secondary ID(s) of Target Chain 42 UniProt (TrEMBL) Alternative ID(s) of Target Chain 42 BindingDB Target Chain Sequence 43 PDB ID(s) of Target Chain 43 UniProt (SwissProt) Recommended Name of Target Chain 43 UniProt (SwissProt) Entry Name of Target Chain 43 UniProt (SwissProt) Primary ID of Target Chain 43 UniProt (SwissProt) Secondary ID(s) of Target Chain 43 UniProt (SwissProt) Alternative ID(s) of Target Chain 43 UniProt (TrEMBL) Submitted Name of Target Chain 43 UniProt (TrEMBL) Entry Name of Target Chain 43 UniProt (TrEMBL) Primary ID of Target Chain 43 UniProt (TrEMBL) Secondary ID(s) of Target Chain 43 UniProt (TrEMBL) Alternative ID(s) of Target Chain 43 BindingDB Target Chain Sequence 44 PDB ID(s) of Target Chain 44 UniProt (SwissProt) Recommended Name of Target Chain 44 UniProt (SwissProt) Entry Name of Target Chain 44 UniProt (SwissProt) Primary ID of Target Chain 44 UniProt (SwissProt) Secondary ID(s) of Target Chain 44 UniProt (SwissProt) Alternative ID(s) of Target Chain 44 UniProt (TrEMBL) Submitted Name of Target Chain 44 UniProt (TrEMBL) Entry Name of Target Chain 44 UniProt (TrEMBL) Primary ID of Target Chain 44 UniProt (TrEMBL) Secondary ID(s) of Target Chain 44 UniProt (TrEMBL) Alternative ID(s) of Target Chain 44 BindingDB Target Chain Sequence 45 PDB ID(s) of Target Chain 45 UniProt (SwissProt) Recommended Name of Target Chain 45 UniProt (SwissProt) Entry Name of Target Chain 45 UniProt (SwissProt) Primary ID of Target Chain 45 UniProt (SwissProt) Secondary ID(s) of Target Chain 45 UniProt (SwissProt) Alternative ID(s) of Target Chain 45 UniProt (TrEMBL) Submitted Name of Target Chain 45 UniProt (TrEMBL) Entry Name of Target Chain 45 UniProt (TrEMBL) Primary ID of Target Chain 45 UniProt (TrEMBL) Secondary ID(s) of Target Chain 45 UniProt (TrEMBL) Alternative ID(s) of Target Chain 45 BindingDB Target Chain Sequence 46 PDB ID(s) of Target Chain 46 UniProt (SwissProt) Recommended Name of Target Chain 46 UniProt (SwissProt) Entry Name of Target Chain 46 UniProt (SwissProt) Primary ID of Target Chain 46 UniProt (SwissProt) Secondary ID(s) of Target Chain 46 UniProt (SwissProt) Alternative ID(s) of Target Chain 46 UniProt (TrEMBL) Submitted Name of Target Chain 46 UniProt (TrEMBL) Entry Name of Target Chain 46 UniProt (TrEMBL) Primary ID of Target Chain 46 UniProt (TrEMBL) Secondary ID(s) of Target Chain 46 UniProt (TrEMBL) Alternative ID(s) of Target Chain 46 BindingDB Target Chain Sequence 47 PDB ID(s) of Target Chain 47 UniProt (SwissProt) Recommended Name of Target Chain 47 UniProt (SwissProt) Entry Name of Target Chain 47 UniProt (SwissProt) Primary ID of Target Chain 47 UniProt (SwissProt) Secondary ID(s) of Target Chain 47 UniProt (SwissProt) Alternative ID(s) of Target Chain 47 UniProt (TrEMBL) Submitted Name of Target Chain 47 UniProt (TrEMBL) Entry Name of Target Chain 47 UniProt (TrEMBL) Primary ID of Target Chain 47 UniProt (TrEMBL) Secondary ID(s) of Target Chain 47 UniProt (TrEMBL) Alternative ID(s) of Target Chain 47 BindingDB Target Chain Sequence 48 PDB ID(s) of Target Chain 48 UniProt (SwissProt) Recommended Name of Target Chain 48 UniProt (SwissProt) Entry Name of Target Chain 48 UniProt (SwissProt) Primary ID of Target Chain 48 UniProt (SwissProt) Secondary ID(s) of Target Chain 48 UniProt (SwissProt) Alternative ID(s) of Target Chain 48 UniProt (TrEMBL) Submitted Name of Target Chain 48 UniProt (TrEMBL) Entry Name of Target Chain 48 UniProt (TrEMBL) Primary ID of Target Chain 48 UniProt (TrEMBL) Secondary ID(s) of Target Chain 48 UniProt (TrEMBL) Alternative ID(s) of Target Chain 48 BindingDB Target Chain Sequence 49 PDB ID(s) of Target Chain 49 UniProt (SwissProt) Recommended Name of Target Chain 49 UniProt (SwissProt) Entry Name of Target Chain 49 UniProt (SwissProt) Primary ID of Target Chain 49 UniProt (SwissProt) Secondary ID(s) of Target Chain 49 UniProt (SwissProt) Alternative ID(s) of Target Chain 49 UniProt (TrEMBL) Submitted Name of Target Chain 49 UniProt (TrEMBL) Entry Name of Target Chain 49 UniProt (TrEMBL) Primary ID of Target Chain 49 UniProt (TrEMBL) Secondary ID(s) of Target Chain 49 UniProt (TrEMBL) Alternative ID(s) of Target Chain 49 BindingDB Target Chain Sequence 50 PDB ID(s) of Target Chain 50 UniProt (SwissProt) Recommended Name of Target Chain 50 UniProt (SwissProt) Entry Name of Target Chain 50 UniProt (SwissProt) Primary ID of Target Chain 50 UniProt (SwissProt) Secondary ID(s) of Target Chain 50 UniProt (SwissProt) Alternative ID(s) of Target Chain 50 UniProt (TrEMBL) Submitted Name of Target Chain 50 UniProt (TrEMBL) Entry Name of Target Chain 50 UniProt (TrEMBL) Primary ID of Target Chain 50 UniProt (TrEMBL) Secondary ID(s) of Target Chain 50 UniProt (TrEMBL) Alternative ID(s) of Target Chain 50 728686 C[C@H](NC(=O)N1CCN(CC1(C)C)c1ncnc2[nH]c(cc12)-c1ccc(C)nc1)c1cccc(Cl)c1 368753 N-[(1S)-1-(3-chlorophenyl)ethyl]-2,2- dimethyl-4-[6-(6-methyl-3-pyridyl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]piperazine-1- carboxamide::US10227357, Compound P-0001 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368753 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368753&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114635 402365553 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728687 C[C@H](NC(=O)N1CCN(CC1(C)C)c1ncnc2[nH]c(cc12)-c1ccc(C)nc1)c1cccc(Cl)c1 368753 N-[(1S)-1-(3-chlorophenyl)ethyl]-2,2- dimethyl-4-[6-(6-methyl-3-pyridyl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]piperazine-1- carboxamide::US10227357, Compound P-0001 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368753 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368753&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114635 402365553 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728688 C[C@H](NC(=O)N1CCN(CC1(C)C)c1ncnc2[nH]c(cc12)-c1ccc(C)nc1)c1cccc(OC(F)F)c1 368754 N-[(1S)-1-[3-(difluoromethoxy)phenyl]ethyl]- 2,2-dimethyl-4-[6-(6-methyl-3-pyridyl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]piperazine-1- carboxamide::US10227357, Compound P-0002 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368754 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368754&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115510 402365554 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728689 C[C@H](NC(=O)N1CCN(CC1(C)C)c1ncnc2[nH]c(cc12)-c1ccc(C)nc1)c1cccc(OC(F)F)c1 368754 N-[(1S)-1-[3-(difluoromethoxy)phenyl]ethyl]- 2,2-dimethyl-4-[6-(6-methyl-3-pyridyl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]piperazine-1- carboxamide::US10227357, Compound P-0002 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368754 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368754&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115510 402365554 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728690 COc1cccc(c1)[C@H](C)NC(=O)N1CCN(CC1)c1ncnc2[nH]c(C)cc12 368755 N-[(1S)-1-(3-methoxyphenyl)ethyl]-4-(6- methyl-7H-pyrrolo[2,3-d]pyrimidin-4- yl)piperazine-1-carboxamide::US10227357, Compound P-0003 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368755 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368755&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115053 402365555 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728691 COc1cccc(c1)[C@H](C)NC(=O)N1CCN(CC1)c1ncnc2[nH]c(C)cc12 368755 N-[(1S)-1-(3-methoxyphenyl)ethyl]-4-(6- methyl-7H-pyrrolo[2,3-d]pyrimidin-4- yl)piperazine-1-carboxamide::US10227357, Compound P-0003 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368755 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368755&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115053 402365555 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728692 COc1cc(ccc1F)[C@H](C)NC(=O)N1CCN(C[C@H]1C)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 368756 (2R)-N-[(1S)-1-(4-fluoro-3-methoxy- phenyl)ethyl]-4-[6-(4-fluorophenyl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]-2-methyl- piperazine-1-carboxamide::US10227357, Compound P-0004 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368756 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368756&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 89993975 402365556 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728693 COc1cc(ccc1F)[C@H](C)NC(=O)N1CCN(C[C@H]1C)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 368756 (2R)-N-[(1S)-1-(4-fluoro-3-methoxy- phenyl)ethyl]-4-[6-(4-fluorophenyl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]-2-methyl- piperazine-1-carboxamide::US10227357, Compound P-0004 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368756 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368756&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 89993975 402365556 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728694 C[C@H](NC(=O)N1CCN(CC1(C)C)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1)c1cccc(F)c1 368757 N-[(1S)-1-(3-fluorophenyl)ethyl]-4-[6-(4- fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]-2,2-dimethyl-piperazine-1-carboxamide::US10227357, Compound P-0005 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368757 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368757&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114818 402365557 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728695 C[C@H](NC(=O)N1CCN(CC1(C)C)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1)c1cccc(F)c1 368757 N-[(1S)-1-(3-fluorophenyl)ethyl]-4-[6-(4- fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]-2,2-dimethyl-piperazine-1-carboxamide::US10227357, Compound P-0005 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368757 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368757&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114818 402365557 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728696 C[C@H](NC(=O)N1CCN(CC1(C)C)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1)c1cccc(OC(F)F)c1 368758 N-[(1S)-1-[3-(difluoromethoxy)phenyl]ethyl]- 4-[6-(4-fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-2,2-dimethyl-piperazine-1- carboxamide::US10227357, Compound P-0006 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368758 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368758&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114372 402365558 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728697 C[C@H](NC(=O)N1CCN(CC1(C)C)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1)c1cccc(OC(F)F)c1 368758 N-[(1S)-1-[3-(difluoromethoxy)phenyl]ethyl]- 4-[6-(4-fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-2,2-dimethyl-piperazine-1- carboxamide::US10227357, Compound P-0006 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368758 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368758&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114372 402365558 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728698 C[C@H](NC(=O)N1CCN(CC1(C)C)c1ncnc2[nH]c(cc12)-c1ccc(C)nc1)c1cccc(F)c1 368759 N-[(1S)-1-(3-fluorophenyl)ethyl]-2,2- dimethyl-4-[6-(6-methyl-3-pyridyl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]piperazine-1- carboxamide::US10227357, Compound P-0007 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368759 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368759&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115004 402365559 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728699 C[C@H](NC(=O)N1CCN(CC1(C)C)c1ncnc2[nH]c(cc12)-c1ccc(C)nc1)c1cccc(F)c1 368759 N-[(1S)-1-(3-fluorophenyl)ethyl]-2,2- dimethyl-4-[6-(6-methyl-3-pyridyl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]piperazine-1- carboxamide::US10227357, Compound P-0007 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368759 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368759&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115004 402365559 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728700 C[C@H](NC(=O)N1CCN(CC1(C)C)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1)c1cccc(Cl)c1 368760 N-[(1S)-1-(3-chlorophenyl)ethyl]-4-[6-(4- fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]-2,2-dimethyl-piperazine-1-carboxamide::US10227357, Compound P-0008 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368760 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368760&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114478 402365560 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728701 C[C@H](NC(=O)N1CCN(CC1(C)C)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1)c1cccc(Cl)c1 368760 N-[(1S)-1-(3-chlorophenyl)ethyl]-4-[6-(4- fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]-2,2-dimethyl-piperazine-1-carboxamide::US10227357, Compound P-0008 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368760 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368760&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114478 402365560 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728702 COc1cccc(c1)C(C)NC(=O)N1CCN(CC1(C)C)c1ncnc2[nH]c(cc12)-c1ccnc(OC)c1 368761 N-[(1S)-1-(3-methoxyphenyl)ethyl]-4-[6-(2- methoxy-4-pyridyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-2,2-dimethyl-piperazine-1- carboxamide::US10227357, Compound P-0009 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368761 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368761&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90134298 402365561 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728703 COc1cccc(c1)C(C)NC(=O)N1CCN(CC1(C)C)c1ncnc2[nH]c(cc12)-c1ccnc(OC)c1 368761 N-[(1S)-1-(3-methoxyphenyl)ethyl]-4-[6-(2- methoxy-4-pyridyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-2,2-dimethyl-piperazine-1- carboxamide::US10227357, Compound P-0009 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368761 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368761&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90134298 402365561 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728704 Cn1cc(cn1)-c1cc2c(ncnc2[nH]1)N1CCN(CC1)c1nc2ccccc2[nH]1 InChI=1S/C21H21N9/c1-28-12-14(11-24-28)18-10-15-19(25-18)22-13-23-20(15)29-6-8-30(9-7-29)21-26-16-4-2-3-5-17(16)27-21/h2-5,10-13H,6-9H2,1H3,(H,26,27)(H,22,23,25) KFAVCGYLYVJNFY-UHFFFAOYSA-N 368762 4-[4-(1H-benzimidazol-2-yl)piperazin-1-yl]-6- (1-methylpyrazol-4-yl)-7H-pyrrolo[2,3- d]pyrimidine::US10227357, Compound P-0010 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368762 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368762&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114528 402365562 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728705 Cn1cc(cn1)-c1cc2c(ncnc2[nH]1)N1CCN(CC1)c1nc2ccccc2[nH]1 InChI=1S/C21H21N9/c1-28-12-14(11-24-28)18-10-15-19(25-18)22-13-23-20(15)29-6-8-30(9-7-29)21-26-16-4-2-3-5-17(16)27-21/h2-5,10-13H,6-9H2,1H3,(H,26,27)(H,22,23,25) KFAVCGYLYVJNFY-UHFFFAOYSA-N 368762 4-[4-(1H-benzimidazol-2-yl)piperazin-1-yl]-6- (1-methylpyrazol-4-yl)-7H-pyrrolo[2,3- d]pyrimidine::US10227357, Compound P-0010 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368762 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368762&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114528 402365562 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728706 Fc1ccc(cc1)-c1cc2c(ncnc2[nH]1)N1CCN(CC1)c1nc2ccccc2[nH]1 InChI=1S/C23H20FN7/c24-16-7-5-15(6-8-16)20-13-17-21(27-20)25-14-26-22(17)30-9-11-31(12-10-30)23-28-18-3-1-2-4-19(18)29-23/h1-8,13-14H,9-12H2,(H,28,29)(H,25,26,27) JRPOKDPREWNZIS-UHFFFAOYSA-N 368763 4-[4-(1H-benzimidazol-2-yl)piperazin-1-yl]-6- (4-fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidine::US10227357, Compound P-0011 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368763 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368763&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114100 402365563 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728707 Fc1ccc(cc1)-c1cc2c(ncnc2[nH]1)N1CCN(CC1)c1nc2ccccc2[nH]1 InChI=1S/C23H20FN7/c24-16-7-5-15(6-8-16)20-13-17-21(27-20)25-14-26-22(17)30-9-11-31(12-10-30)23-28-18-3-1-2-4-19(18)29-23/h1-8,13-14H,9-12H2,(H,28,29)(H,25,26,27) JRPOKDPREWNZIS-UHFFFAOYSA-N 368763 4-[4-(1H-benzimidazol-2-yl)piperazin-1-yl]-6- (4-fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidine::US10227357, Compound P-0011 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368763 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368763&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114100 402365563 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728708 COc1cc(ccn1)-c1cc2c(ncnc2[nH]1)N1CCN(C(=O)N[C@@H](C)c2cccc(OC(F)F)c2)C(C)(C)C1 368764 N-[(1S)-1-[3-(difluoromethoxy)phenyl]ethyl]- 4-[6-(2-methoxy-4-pyridyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-2,2-dimethyl-piperazine-1- carboxamide::US10227357, Compound P-0012 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368764 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368764&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 73389132 402365564 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728709 COc1cc(ccn1)-c1cc2c(ncnc2[nH]1)N1CCN(C(=O)N[C@@H](C)c2cccc(OC(F)F)c2)C(C)(C)C1 368764 N-[(1S)-1-[3-(difluoromethoxy)phenyl]ethyl]- 4-[6-(2-methoxy-4-pyridyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-2,2-dimethyl-piperazine-1- carboxamide::US10227357, Compound P-0012 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368764 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368764&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 73389132 402365564 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728710 Cc1ccc(cn1)-c1cc2c(ncnc2[nH]1)N1CCN(CC1)c1nc2ccccc2[nH]1 InChI=1S/C23H22N8/c1-15-6-7-16(13-24-15)20-12-17-21(27-20)25-14-26-22(17)30-8-10-31(11-9-30)23-28-18-4-2-3-5-19(18)29-23/h2-7,12-14H,8-11H2,1H3,(H,28,29)(H,25,26,27) JECANMLWCZKICC-UHFFFAOYSA-N 368765 4-[4-(1H-benzimidazol-2-yl)piperazin-1-yl]-6- (6-methyl-3-pyridyl)-7H-pyrrolo[2,3- d]pyrimidine::US10227357, Compound P-0013 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368765 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368765&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114330 402365565 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728711 Cc1ccc(cn1)-c1cc2c(ncnc2[nH]1)N1CCN(CC1)c1nc2ccccc2[nH]1 InChI=1S/C23H22N8/c1-15-6-7-16(13-24-15)20-12-17-21(27-20)25-14-26-22(17)30-8-10-31(11-9-30)23-28-18-4-2-3-5-19(18)29-23/h2-7,12-14H,8-11H2,1H3,(H,28,29)(H,25,26,27) JECANMLWCZKICC-UHFFFAOYSA-N 368765 4-[4-(1H-benzimidazol-2-yl)piperazin-1-yl]-6- (6-methyl-3-pyridyl)-7H-pyrrolo[2,3- d]pyrimidine::US10227357, Compound P-0013 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368765 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368765&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114330 402365565 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728712 C[C@H](NC(=O)N1CCN(C[C@H]1C)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1)c1cccc(OC(F)F)c1 368766 (2R)-N-[(1S)-1-[3- (difluoromethoxy)phenyl]ethyl]-4-[6-(4- fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]-2-methyl-piperazine-1-carboxamide::US10227357, Compound P-0014 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368766 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368766&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115246 402365566 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728713 C[C@H](NC(=O)N1CCN(C[C@H]1C)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1)c1cccc(OC(F)F)c1 368766 (2R)-N-[(1S)-1-[3- (difluoromethoxy)phenyl]ethyl]-4-[6-(4- fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]-2-methyl-piperazine-1-carboxamide::US10227357, Compound P-0014 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368766 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368766&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115246 402365566 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728714 COc1cccc(c1)[C@H](C)NC(=O)N1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 368767 4-[6-(4-fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[(1S)-1-[3- (trideuteriomethoxy)phenyl]ethyl]piperazine- 1-carboxamide::US10227357, Compound P-0015::US10227357, Compound P-0144 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368767 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368767&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114806 402365567 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728715 COc1cccc(c1)[C@H](C)NC(=O)N1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 368767 4-[6-(4-fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[(1S)-1-[3- (trideuteriomethoxy)phenyl]ethyl]piperazine- 1-carboxamide::US10227357, Compound P-0015::US10227357, Compound P-0144 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368767 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368767&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114806 402365567 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728716 C[C@H](NC(=O)N1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1)c1cccc(c1)N(C)C 368768 N-[(1S)-1-[3-(dimethylamino)phenyl]ethyl]-4- [6-(4-fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]piperazine-1-carboxamide::US10227357, Compound P-0016 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368768 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368768&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114888 402365568 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728717 C[C@H](NC(=O)N1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1)c1cccc(c1)N(C)C 368768 N-[(1S)-1-[3-(dimethylamino)phenyl]ethyl]-4- [6-(4-fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]piperazine-1-carboxamide::US10227357, Compound P-0016 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368768 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368768&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114888 402365568 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728718 CC(C)(C)Oc1ccc(NC(=O)N2CCN(CC2)c2ncnc3[nH]c(cc23)-c2ccc(Cl)cc2)cc1 InChI=1S/C27H29ClN6O2/c1-27(2,3)36-21-10-8-20(9-11-21)31-26(35)34-14-12-33(13-15-34)25-22-16-23(32-24(22)29-17-30-25)18-4-6-19(28)7-5-18/h4-11,16-17H,12-15H2,1-3H3,(H,31,35)(H,29,30,32) NPGURYNZYCJVLR-UHFFFAOYSA-N 368769 N-(4-tert-butoxyphenyl)-4-[6-(4- chlorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]piperazine-1-carboxamide::US10227357, Compound P-0017 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368769 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368769&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114865 402365569 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728719 COc1ccc(cc1)[C@H](C)NC(=O)N1CCN(C[C@H]1C)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 368770 (2R)-4-[6-(4-fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[(1S)-1-(4- methoxyphenyl)ethyl]-2-methyl-piperazine- 1-carboxamide::US10227357, Compound P-0018 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368770 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368770&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115491 402365570 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728720 COc1ccc(cc1)[C@H](C)NC(=O)N1CCN(C[C@H]1C)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 368770 (2R)-4-[6-(4-fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[(1S)-1-(4- methoxyphenyl)ethyl]-2-methyl-piperazine- 1-carboxamide::US10227357, Compound P-0018 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368770 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368770&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115491 402365570 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728721 COc1ccc(cc1)[C@@H](C)NC(=O)N1CCN(C[C@H]1C)c1ncnc2[nH]c(cc12)-c1ccc(Cl)cc1 368771 (2R)-4-[6-(4-chlorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[(1R)-1-(4- methoxyphenyl)ethyl]-2-methyl-piperazine- 1-carboxamide::US10227357, Compound P-0019 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368771 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368771&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114426 402365571 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728722 COc1ccc(cc1)[C@@H](C)NC(=O)N1CCN(C[C@H]1C)c1ncnc2[nH]c(cc12)-c1ccc(Cl)cc1 368771 (2R)-4-[6-(4-chlorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[(1R)-1-(4- methoxyphenyl)ethyl]-2-methyl-piperazine- 1-carboxamide::US10227357, Compound P-0019 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368771 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368771&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114426 402365571 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728723 C[C@H](NC(=O)N1CCN(C[C@H]1C)c1ncnc2[nH]c(cc12)-c1ccc(Cl)cc1)c1ccc(Cl)cc1 368772 (2R)-N-[(1S)-1-(4-chlorophenyl)ethyl]-4-[6-(4- chlorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]-2-methyl-piperazine-1-carboxamide::US10227357, Compound P-0020 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368772 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368772&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115486 402365572 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728724 C[C@H](NC(=O)N1CCN(C[C@H]1C)c1ncnc2[nH]c(cc12)-c1ccc(Cl)cc1)c1ccc(Cl)cc1 368772 (2R)-N-[(1S)-1-(4-chlorophenyl)ethyl]-4-[6-(4- chlorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]-2-methyl-piperazine-1-carboxamide::US10227357, Compound P-0020 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368772 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368772&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115486 402365572 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728725 C[C@@H](NC(=O)N1CCN(C[C@H]1C)c1ncnc2[nH]c(cc12)-c1ccc(Cl)cc1)c1ccc(Cl)cc1 368773 (2R)-N-[(1S)-1-(4-chlorophenyl)ethyl]-4-[6-(4- chlorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]-2-methyl-piperazine-1-carboxamide::US10227357, Compound P-0021 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368773 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368773&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90137123 402365573 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728726 C[C@@H](NC(=O)N1CCN(C[C@H]1C)c1ncnc2[nH]c(cc12)-c1ccc(Cl)cc1)c1ccc(F)cc1 368774 (2R)-4-[6-(4-chlorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[(1R)-1-(4- fluorophenyl)ethyl]-2-methyl-piperazine-1- carboxamide::US10227357, Compound P-0022 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368774 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368774&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114583 402365574 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728727 C[C@H](NC(=O)N1CCN(C[C@H]1C)c1ncnc2[nH]c(cc12)-c1ccc(Cl)cc1)c1ccc(F)cc1 368775 (2R)-4-[6-(4-chlorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[(1S)-1-(4- fluorophenyl)ethyl]-2-methyl-piperazine-1- carboxamide::US10227357, Compound P-0023 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368775 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368775&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114639 402365575 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728728 C[C@H](NC(=O)N1CCN(C[C@H]1C)c1ncnc2[nH]c(cc12)-c1ccc(Cl)cc1)c1ccc(F)cc1 368775 (2R)-4-[6-(4-chlorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[(1S)-1-(4- fluorophenyl)ethyl]-2-methyl-piperazine-1- carboxamide::US10227357, Compound P-0023 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368775 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368775&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114639 402365575 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728729 COc1cccc(c1)[C@H](C)NC(=O)N1CCN(C[C@H]1C)c1ncnc2[nH]c(cc12)-c1ccc(Cl)cc1 368776 (2R)-4-[6-(4-chlorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[(1S)-1-(3- methoxyphenyl)ethyl]-2-methyl-piperazine- 1-carboxamide::US10227357, Compound P-0024 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368776 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368776&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114556 402365576 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728730 COc1cccc(c1)[C@H](C)NC(=O)N1CCN(C[C@H]1C)c1ncnc2[nH]c(cc12)-c1ccc(Cl)cc1 368776 (2R)-4-[6-(4-chlorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[(1S)-1-(3- methoxyphenyl)ethyl]-2-methyl-piperazine- 1-carboxamide::US10227357, Compound P-0024 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368776 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368776&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114556 402365576 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728731 COc1cccc(c1)[C@@H](C)NC(=O)N1CCN(C[C@H]1C)c1ncnc2[nH]c(cc12)-c1ccc(Cl)cc1 368777 (2R)-4-[6-(4-chlorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[(1R)-1-(3- methoxyphenyl)ethyl]-2-methyl-piperazine- 1-carboxamide::US10227357, Compound P-0025 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368777 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368777&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114536 402365577 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728732 Fc1ccc(cc1)-c1cc2c(ncnc2[nH]1)N1CCN(CC1)NS(=O)(=O)c1ccc(OC(F)(F)F)cc1 InChI=1S/C23H20F4N6O3S/c24-16-3-1-15(2-4-16)20-13-19-21(30-20)28-14-29-22(19)32-9-11-33(12-10-32)31-37(34,35)18-7-5-17(6-8-18)36-23(25,26)27/h1-8,13-14,31H,9-12H2,(H,28,29,30) GIZSTEOZDPNNCN-UHFFFAOYSA-N 368778 N-[4-[6-(4-fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]piperazin-1-yl]-4- (trifluoromethoxy)benzenesulfonamide::US10227357, Compound P-0026 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368778 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368778&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114626 402365578 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728733 C[C@H](NC(=O)N1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1)c1cccc(Cl)c1 368779 N-[(1S)-1-(3-chlorophenyl)ethyl]-4-[6-(4- fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]piperazine-1-carboxamide::US10227357, Compound P-0027 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368779 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368779&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 73291754 402365579 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728734 C[C@H](NC(=O)N1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1)c1cccc(Cl)c1 368779 N-[(1S)-1-(3-chlorophenyl)ethyl]-4-[6-(4- fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]piperazine-1-carboxamide::US10227357, Compound P-0027 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368779 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368779&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 73291754 402365579 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728735 COc1cccc(c1)[C@H](C)NC(=O)N1CCN(C[C@H]1C)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 368780 (2R)-4-[6-(4-fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[(1S)-1-(3- methoxyphenyl)ethyl]-2-methyl-piperazine- 1-carboxamide::US10227357, Compound P-0028 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368780 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368780&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 73389131 402365580 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728736 COc1cccc(c1)[C@H](C)NC(=O)N1CCN(C[C@H]1C)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 368780 (2R)-4-[6-(4-fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[(1S)-1-(3- methoxyphenyl)ethyl]-2-methyl-piperazine- 1-carboxamide::US10227357, Compound P-0028 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368780 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368780&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 73389131 402365580 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728737 C[C@H](NC(=O)N1CCN(C[C@H]1C)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1)c1ccc(Cl)cc1 368781 (2R)-N-[(1S)-1-(4-chlorophenyl)ethyl]-4-[6-(4- fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]-2-methyl-piperazine-1-carboxamide::US10227357, Compound P-0029 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368781 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368781&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114637 402365581 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728738 C[C@H](NC(=O)N1CCN(C[C@H]1C)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1)c1ccc(Cl)cc1 368781 (2R)-N-[(1S)-1-(4-chlorophenyl)ethyl]-4-[6-(4- fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]-2-methyl-piperazine-1-carboxamide::US10227357, Compound P-0029 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368781 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368781&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114637 402365581 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728739 C[C@H](NC(=O)N1CCN(C[C@H]1C)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1)c1ccc(F)cc1 368782 (2R)-N-[(1S)-1-(4-fluorophenyl)ethyl]-4-[6-(4- fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]-2-methyl-piperazine-1-carboxamide::US10227357, Compound P-0030 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368782 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368782&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114348 402365582 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728740 C[C@H](NC(=O)N1CCN(C[C@H]1C)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1)c1ccc(F)cc1 368782 (2R)-N-[(1S)-1-(4-fluorophenyl)ethyl]-4-[6-(4- fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]-2-methyl-piperazine-1-carboxamide::US10227357, Compound P-0030 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368782 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368782&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114348 402365582 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728741 COc1ccc(cc1)[C@@H](C)NC(=O)N1CCN(C[C@H]1C)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 368783 (2R)-4-[6-(4-fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[(1R)-1-(4- methoxyphenyl)ethyl]-2-methyl-piperazine- 1-carboxamide::US10227357, Compound P-0031 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368783 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368783&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114376 402365583 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728742 COc1ccc(cc1)[C@@H](C)NC(=O)N1CCN(C[C@H]1C)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 368783 (2R)-4-[6-(4-fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[(1R)-1-(4- methoxyphenyl)ethyl]-2-methyl-piperazine- 1-carboxamide::US10227357, Compound P-0031 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368783 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368783&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114376 402365583 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728743 COc1cccc(c1)[C@@H](C)NC(=O)N1CCN(C[C@H]1C)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 368784 (2R)-4-[6-(4-fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[(1R)-1-(3- methoxyphenyl)ethyl]-2-methyl-piperazine- 1-carboxamide::US10227357, Compound P-0032 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368784 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368784&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115114 402365584 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728744 COc1cccc(c1)[C@@H](C)NC(=O)N1CCN(C[C@H]1C)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 368784 (2R)-4-[6-(4-fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[(1R)-1-(3- methoxyphenyl)ethyl]-2-methyl-piperazine- 1-carboxamide::US10227357, Compound P-0032 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368784 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368784&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115114 402365584 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728745 C[C@H](NC(=O)N1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1)c1cccc(c1)C(F)(F)F 368785 4-[6-(4-fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[(1S)-1-[3- (trifluoromethyl)phenyl]ethyl]piperazine-1- carboxamide::US10227357, Compound P-0033 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368785 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368785&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114480 402365585 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728746 C[C@@H](NC(=O)N1CCN(C[C@H]1C)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1)c1ccc(F)cc1 368786 (2R)-N-[(1R)-1-(4-fluorophenyl)ethyl]-4-[6-(4- fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]-2-methyl-piperazine-1-carboxamide::US10227357, Compound P-0034 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368786 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368786&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114039 402365586 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728747 C[C@@H](NC(=O)N1CCN(C[C@H]1C)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1)c1ccc(Cl)cc1 368787 (2R)-N-[(1R)-1-(4-chlorophenyl)ethyl]-4-[6-(4- fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]-2-methyl-piperazine-1-carboxamide::US10227357, Compound P-0035 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368787 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368787&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90113995 402365587 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728748 C[C@@H](NC(=O)N1CCN(C[C@H]1C)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1)c1ccc(Cl)cc1 368787 (2R)-N-[(1R)-1-(4-chlorophenyl)ethyl]-4-[6-(4- fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]-2-methyl-piperazine-1-carboxamide::US10227357, Compound P-0035 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368787 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368787&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90113995 402365587 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728749 C[C@H](NC(=O)N1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1)c1cccc(F)c1 368788 N-[(1S)-1-(3-fluorophenyl)ethyl]-4-[6-(4- fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]piperazine-1-carboxamide::US10227357, Compound P-0036 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368788 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368788&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115286 402365588 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728750 FC(F)Oc1cccc(CNC(=O)N2CCN(CC2)c2ncnc3[nH]c(cc23)-c2ccc(Cl)cc2)c1 InChI=1S/C25H23ClF2N6O2/c26-18-6-4-17(5-7-18)21-13-20-22(32-21)30-15-31-23(20)33-8-10-34(11-9-33)25(35)29-14-16-2-1-3-19(12-16)36-24(27)28/h1-7,12-13,15,24H,8-11,14H2,(H,29,35)(H,30,31,32) WPVSHLKORRTAKF-UHFFFAOYSA-N 368789 4-[6-(4-chlorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[[3- (difluoromethoxy)phenyl]methyl]piperazine- 1-carboxamide::US10227357, Compound P-0037 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368789 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368789&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114759 402365589 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728751 COc1cccc(c1)[C@H](C)NC(=O)N1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(Cl)cc1 368790 4-[6-(4-chlorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[(1S)-1-(3- methoxyphenyl)ethyl]piperazine-1- carboxamide::US10227357, Compound P-0038 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368790 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368790&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115466 402365590 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728752 C[C@H]1CN(CCN1C(=O)Nc1ccc(C)nc1)c1ncnc2[nH]c(cc12)-c1ccncc1 368791 (2S)-2-methyl-N-(6-methyl-3-pyridyl)-4-[6-(4- pyridyl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]piperazine-1-carboxamide::US10227357, Compound P-0039 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368791 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368791&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114733 402365591 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728753 C[C@H]1CN(CCN1C(=O)NCc1cccc(Cl)c1)c1ncnc2[nH]c(cc12)-c1ccncc1 368792 (2S)-N-[(3-chlorophenyl)methyl]-2-methyl-4- [6-(4-pyridyl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]piperazine-1-carboxamide::US10227357, Compound P-0040 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368792 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368792&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115203 402365592 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728754 C[C@H]1CN(CCN1C(=O)NCc1ccc(F)cc1)c1ncnc2[nH]c(cc12)-c1ccncc1 368793 (2S)-N-[(4-fluorophenyl)methyl]-2-methyl-4- [6-(4-pyridyl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]piperazine-1-carboxamide::US10227357, Compound P-0041 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368793 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368793&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114794 402365593 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728755 C[C@H]1CN(CCN1C(=O)Nc1ccc(OC(F)(F)F)cc1)c1ncnc2[nH]c(cc12)-c1ccncc1 368794 (2S)-2-methyl-4-[6-(4-pyridyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[4- (trifluoromethoxy)phenyl]piperazine-1- carboxamide::US10227357, Compound P-0043 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368794 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368794&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114185 402365594 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728756 C[C@H]1CN(CCN1C(=O)NCc1ccc(Cl)cc1)c1ncnc2[nH]c(cc12)-c1ccncc1 368795 (2S)-N-[(4-chlorophenyl)methyl]-2-methyl-4- [6-(4-pyridyl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]piperazine-1-carboxamide::US10227357, Compound P-0044 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368795 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368795&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114439 402365595 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728757 C[C@H]1CN(CCN1C(=O)NCc1ccc(Cl)cc1)c1ncnc2[nH]c(cc12)-c1ccncc1 368795 (2S)-N-[(4-chlorophenyl)methyl]-2-methyl-4- [6-(4-pyridyl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]piperazine-1-carboxamide::US10227357, Compound P-0044 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368795 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368795&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114439 402365595 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728758 C[C@H]1CN(CCN1C(=O)Nc1ccc(Cl)cc1)c1ncnc2[nH]c(cc12)-c1ccncc1 368796 (2S)-N-(4-chlorophenyl)-2-methyl-4-[6-(4- pyridyl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]piperazine-1-carboxamide::US10227357, Compound P-0045 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368796 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368796&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115172 402365596 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728759 C[C@H]1CN(CCN1C(=O)Nc1ccc(Cl)cc1)c1ncnc2[nH]c(cc12)-c1ccncc1 368796 (2S)-N-(4-chlorophenyl)-2-methyl-4-[6-(4- pyridyl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]piperazine-1-carboxamide::US10227357, Compound P-0045 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368796 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368796&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115172 402365596 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728760 C[C@H]1CN(CCN1C(=O)Nc1ccc(cc1)N(C)C)c1ncnc2[nH]c(cc12)-c1ccncc1 368797 (2S)-N-(4-dimethylaminophenyl)-2-methyl-4- [6-(4-pyridyl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]piperazine-1-carboxamide::US10227357, Compound P-0046 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368797 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368797&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115083 402365597 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728761 COc1cccc(c1)[C@H](C)NC(=O)N1CCN(CC1)c1ncnc2[nH]c(cc12)C#CC1CC1 368798 4-[6-(2-cyclopropylethynyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[(1S)-1-(3- methoxyphenyl)ethyl]piperazine-1- carboxamide::US10227357, Compound P-0047 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368798 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368798&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115041 402365598 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728762 COc1cccc(c1)[C@H](C)NC(=O)N1CCN(CC1)c1ncnc2[nH]c(cc12)C#CC1CC1 368798 4-[6-(2-cyclopropylethynyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[(1S)-1-(3- methoxyphenyl)ethyl]piperazine-1- carboxamide::US10227357, Compound P-0047 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368798 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368798&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115041 402365598 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728763 CCC(NC(=O)N1CCN(C[C@@H]1C)c1ncnc2[nH]c(cc12)-c1ccncc1)c1ccccc1 368799 (2S)-2-methyl-N-[(1S)-1-phenylpropyl]-4-[6- (4-pyridyl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]piperazine-1-carboxamide::US10227357, Compound P-0048 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368799 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368799&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90137115 402365599 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728764 CC(NC(=O)N1CCN(C[C@@H]1C)c1ncnc2[nH]c(cc12)-c1ccncc1)c1ccc(F)cc1 368800 (2S)-N-[(1S)-1-(4-fluorophenyl)ethyl]-2- methyl-4-[6-(4-pyridyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]piperazine-1-carboxamide::US10227357, Compound P-0049 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368800 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368800&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90134696 402365600 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728765 CC(NC(=O)N1CCN(C[C@@H]1C)c1ncnc2[nH]c(cc12)-c1ccncc1)c1ccc(Cl)cc1 368801 (2S)-N-[(1S)-1-(4-chlorophenyl)ethyl]-2- methyl-4-[6-(4-pyridyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]piperazine-1-carboxamide::US10227357, Compound P-0050 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368801 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368801&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 89993979 402365601 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728766 COc1cccc(c1)C(C)NC(=O)N1CCN(C[C@@H]1C)c1ncnc2[nH]c(cc12)-c1ccncc1 368802 (2S)-N-[(1S)-1-(3-methoxyphenyl)ethyl]-2- methyl-4-[6-(4-pyridyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]piperazine-1-carboxamide::US10227357, Compound P-0051 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368802 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368802&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 89993980 402365602 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728767 CN(C)c1ccc(NC(=O)N2CCN(CC2)c2ncnc3[nH]c(cc23)C#CC2CC2)cc1 InChI=1S/C24H27N7O/c1-29(2)20-9-7-18(8-10-20)28-24(32)31-13-11-30(12-14-31)23-21-15-19(6-5-17-3-4-17)27-22(21)25-16-26-23/h7-10,15-17H,3-4,11-14H2,1-2H3,(H,28,32)(H,25,26,27) CVKYOOGRXQNCIS-UHFFFAOYSA-N 368803 4-[6-(2-cyclopropylethynyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-(4- dimethylaminophenyl)piperazine-1- carboxamide::US10227357, Compound P-0052 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368803 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368803&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115403 402365603 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728768 CN(C)c1ccc(NC(=O)N2CCN(CC2)c2ncnc3[nH]c(cc23)C#CC2CC2)cc1 InChI=1S/C24H27N7O/c1-29(2)20-9-7-18(8-10-20)28-24(32)31-13-11-30(12-14-31)23-21-15-19(6-5-17-3-4-17)27-22(21)25-16-26-23/h7-10,15-17H,3-4,11-14H2,1-2H3,(H,28,32)(H,25,26,27) CVKYOOGRXQNCIS-UHFFFAOYSA-N 368803 4-[6-(2-cyclopropylethynyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-(4- dimethylaminophenyl)piperazine-1- carboxamide::US10227357, Compound P-0052 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368803 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368803&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115403 402365603 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728769 FC(F)(F)Oc1ccc(NC(=O)N2CCN(CC2)c2ncnc3[nH]c(cc23)C#CC2CC2)cc1 InChI=1S/C23H21F3N6O2/c24-23(25,26)34-18-7-5-16(6-8-18)30-22(33)32-11-9-31(10-12-32)21-19-13-17(4-3-15-1-2-15)29-20(19)27-14-28-21/h5-8,13-15H,1-2,9-12H2,(H,30,33)(H,27,28,29) WQETUYOJBXCPQI-UHFFFAOYSA-N 368804 4-[6-(2-cyclopropylethynyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[4- (trifluoromethoxy)phenyl]piperazine-1- carboxamide::US10227357, Compound P-0053 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368804 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368804&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114384 402365604 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728770 FC(F)(F)Oc1ccc(NC(=O)N2CCN(CC2)c2ncnc3[nH]c(cc23)C#CC2CC2)cc1 InChI=1S/C23H21F3N6O2/c24-23(25,26)34-18-7-5-16(6-8-18)30-22(33)32-11-9-31(10-12-32)21-19-13-17(4-3-15-1-2-15)29-20(19)27-14-28-21/h5-8,13-15H,1-2,9-12H2,(H,30,33)(H,27,28,29) WQETUYOJBXCPQI-UHFFFAOYSA-N 368804 4-[6-(2-cyclopropylethynyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[4- (trifluoromethoxy)phenyl]piperazine-1- carboxamide::US10227357, Compound P-0053 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368804 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368804&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114384 402365604 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728771 CCC(NC(=O)N1CCN(CC1C)c1ncnc2[nH]c(cc12)-c1ccncc1)c1ccccc1 368805 (2R)-2-methyl-N-[(1S)-1-phenylpropyl]-4-[6- (4-pyridyl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]piperazine-1-carboxamide::US10227357, Compound P-0054 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368805 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368805&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 89993984 402365605 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728772 C[C@@H]1CN(CCN1C(=O)Nc1ccc(C)nc1)c1ncnc2[nH]c(cc12)-c1ccncc1 368806 (2R)-2-methyl-N-(6-methyl-3-pyridyl)-4-[6-(4- pyridyl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]piperazine-1-carboxamide::US10227357, Compound P-0055 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368806 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368806&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115038 402365606 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728773 C[C@@H]1CN(CCN1C(=O)NCc1cccc(Cl)c1)c1ncnc2[nH]c(cc12)-c1ccncc1 368807 (2R)-N-[(3-chlorophenyl)methyl]-2-methyl-4- [6-(4-pyridyl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]piperazine-1-carboxamide::US10227357, Compound P-0056 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368807 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368807&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114523 402365607 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728774 C[C@@H]1CN(CCN1C(=O)NCc1cccc(Cl)c1)c1ncnc2[nH]c(cc12)-c1ccncc1 368807 (2R)-N-[(3-chlorophenyl)methyl]-2-methyl-4- [6-(4-pyridyl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]piperazine-1-carboxamide::US10227357, Compound P-0056 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368807 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368807&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114523 402365607 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728775 COc1ccc(NC(=O)N2CCN(C[C@H]2C)c2ncnc3[nH]c(cc23)-c2ccncc2)cn1 368808 (2R)-N-(6-methoxy-3-pyridyl)-2-methyl-4-[6- (4-pyridyl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]piperazine-1-carboxamide::US10227357, Compound P-0057 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368808 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368808&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90137113 402365608 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728776 COc1ccc(NC(=O)N2CCN(C[C@H]2C)c2ncnc3[nH]c(cc23)-c2ccncc2)cn1 368808 (2R)-N-(6-methoxy-3-pyridyl)-2-methyl-4-[6- (4-pyridyl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]piperazine-1-carboxamide::US10227357, Compound P-0057 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368808 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368808&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90137113 402365608 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728777 C[C@H](NC(=O)N1CCN(C[C@H]1C)c1ncnc2[nH]c(cc12)-c1ccncc1)c1ccc(F)cc1 368809 (2R)-N-[(1S)-1-(4-fluorophenyl)ethyl]-2- methyl-4-[6-(4-pyridyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]piperazine-1-carboxamide::US10227357, Compound P-0058 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368809 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368809&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114233 402365609 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728778 C[C@H](NC(=O)N1CCN(C[C@H]1C)c1ncnc2[nH]c(cc12)-c1ccncc1)c1ccc(F)cc1 368809 (2R)-N-[(1S)-1-(4-fluorophenyl)ethyl]-2- methyl-4-[6-(4-pyridyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]piperazine-1-carboxamide::US10227357, Compound P-0058 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368809 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368809&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114233 402365609 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728779 C[C@H](NC(=O)N1CCN(C[C@H]1C)c1ncnc2[nH]c(cc12)-c1ccncc1)c1ccc(Cl)cc1 368810 (2R)-N-[(1S)-1-(4-chlorophenyl)ethyl]-2- methyl-4-[6-(4-pyridyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]piperazine-1-carboxamide::US10227357, Compound P-0059 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368810 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368810&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114996 402365610 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728780 C[C@H](NC(=O)N1CCN(C[C@H]1C)c1ncnc2[nH]c(cc12)-c1ccncc1)c1ccc(Cl)cc1 368810 (2R)-N-[(1S)-1-(4-chlorophenyl)ethyl]-2- methyl-4-[6-(4-pyridyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]piperazine-1-carboxamide::US10227357, Compound P-0059 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368810 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368810&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114996 402365610 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728781 COc1cccc(c1)[C@H](C)NC(=O)N1CCN(C[C@H]1C)c1ncnc2[nH]c(cc12)-c1ccncc1 368811 (2R)-N-[(1S)-1-(3-methoxyphenyl)ethyl]-2- methyl-4-[6-(4-pyridyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]piperazine-1-carboxamide::US10227357, Compound P-0060 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368811 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368811&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115321 402365611 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728782 COc1cccc(c1)[C@H](C)NC(=O)N1CCN(C[C@H]1C)c1ncnc2[nH]c(cc12)-c1ccncc1 368811 (2R)-N-[(1S)-1-(3-methoxyphenyl)ethyl]-2- methyl-4-[6-(4-pyridyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]piperazine-1-carboxamide::US10227357, Compound P-0060 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368811 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368811&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115321 402365611 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728783 C[C@@H]1CN(CCN1C(=O)NCc1ccc(F)cc1)c1ncnc2[nH]c(cc12)-c1ccncc1 368812 (2R)-N-[(4-fluorophenyl)methyl]-2-methyl-4- [6-(4-pyridyl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]piperazine-1-carboxamide::US10227357, Compound P-0061 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368812 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368812&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114689 402365612 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728784 C[C@@H]1CN(CCN1C(=O)NCc1ccc(F)cc1)c1ncnc2[nH]c(cc12)-c1ccncc1 368812 (2R)-N-[(4-fluorophenyl)methyl]-2-methyl-4- [6-(4-pyridyl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]piperazine-1-carboxamide::US10227357, Compound P-0061 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368812 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368812&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114689 402365612 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728785 C[C@@H]1CN(CCN1C(=O)Nc1ccc(F)c(Cl)c1)c1ncnc2[nH]c(cc12)-c1ccncc1 368813 (2R)-N-(3-chloro-4-fluoro-phenyl)-2-methyl- 4-[6-(4-pyridyl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]piperazine-1-carboxamide::US10227357, Compound P-0062 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368813 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368813&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114662 402365613 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728786 C[C@@H]1CN(CCN1C(=O)Nc1ccc(F)c(Cl)c1)c1ncnc2[nH]c(cc12)-c1ccncc1 368813 (2R)-N-(3-chloro-4-fluoro-phenyl)-2-methyl- 4-[6-(4-pyridyl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]piperazine-1-carboxamide::US10227357, Compound P-0062 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368813 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368813&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114662 402365613 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728787 C[C@@H]1CN(CCN1C(=O)Nc1ccc(OC(F)(F)F)cc1)c1ncnc2[nH]c(cc12)-c1ccncc1 368814 (2R)-2-methyl-4-[6-(4-pyridyl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]-N-[4- (trifluoromethoxy)phenyl]piperazine-1- carboxamide::US10227357, Compound P-0063 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368814 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368814&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114851 402365614 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728788 C[C@@H]1CN(CCN1C(=O)Nc1ccc(OC(F)(F)F)cc1)c1ncnc2[nH]c(cc12)-c1ccncc1 368814 (2R)-2-methyl-4-[6-(4-pyridyl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]-N-[4- (trifluoromethoxy)phenyl]piperazine-1- carboxamide::US10227357, Compound P-0063 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368814 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368814&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114851 402365614 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728789 C[C@@H]1CN(CCN1C(=O)NCc1ccc(Cl)cc1)c1ncnc2[nH]c(cc12)-c1ccncc1 368815 (2R)-N-[(4-chlorophenyl)methyl]-2-methyl-4- [6-(4-pyridyl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]piperazine-1-carboxamide::US10227357, Compound P-0064 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368815 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368815&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114250 402365615 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728790 C[C@@H]1CN(CCN1C(=O)NCc1ccc(Cl)cc1)c1ncnc2[nH]c(cc12)-c1ccncc1 368815 (2R)-N-[(4-chlorophenyl)methyl]-2-methyl-4- [6-(4-pyridyl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]piperazine-1-carboxamide::US10227357, Compound P-0064 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368815 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368815&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114250 402365615 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728791 C[C@@H]1CN(CCN1C(=O)Nc1ccc(Cl)cc1)c1ncnc2[nH]c(cc12)-c1ccncc1 368816 (2R)-N-(4-chlorophenyl)-2-methyl-4-[6-(4- pyridyl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]piperazine-1-carboxamide::US10227357, Compound P-0065 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368816 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368816&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115427 402365616 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728792 C[C@@H]1CN(CCN1C(=O)Nc1ccc(Cl)cc1)c1ncnc2[nH]c(cc12)-c1ccncc1 368816 (2R)-N-(4-chlorophenyl)-2-methyl-4-[6-(4- pyridyl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]piperazine-1-carboxamide::US10227357, Compound P-0065 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368816 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368816&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115427 402365616 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728793 C[C@@H]1CN(CCN1C(=O)Nc1ccc(cc1)N(C)C)c1ncnc2[nH]c(cc12)-c1ccncc1 368817 (2R)-N-(4-dimethylaminophenyl)-2-methyl-4- [6-(4-pyridyl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]piperazine-1-carboxamide::US10227357, Compound P-0066 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368817 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368817&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114483 402365617 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728794 C[C@@H]1CN(CCN1C(=O)Nc1ccc(cc1)N(C)C)c1ncnc2[nH]c(cc12)-c1ccncc1 368817 (2R)-N-(4-dimethylaminophenyl)-2-methyl-4- [6-(4-pyridyl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]piperazine-1-carboxamide::US10227357, Compound P-0066 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368817 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368817&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114483 402365617 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728795 Fc1ccccc1-c1cc2c(ncnc2[nH]1)N1CCN(CC1)C(=O)Nc1ccc(OC(F)(F)F)cc1 InChI=1S/C24H20F4N6O2/c25-19-4-2-1-3-17(19)20-13-18-21(32-20)29-14-30-22(18)33-9-11-34(12-10-33)23(35)31-15-5-7-16(8-6-15)36-24(26,27)28/h1-8,13-14H,9-12H2,(H,31,35)(H,29,30,32) URBLJLPZSXNERE-UHFFFAOYSA-N 368818 4-[6-(2-fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[4- (trifluoromethoxy)phenyl]piperazine-1- carboxamide::US10227357, Compound P-0067 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368818 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368818&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114464 402365618 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728796 Fc1ccccc1-c1cc2c(ncnc2[nH]1)N1CCN(CC1)C(=O)Nc1ccc(OC(F)(F)F)cc1 InChI=1S/C24H20F4N6O2/c25-19-4-2-1-3-17(19)20-13-18-21(32-20)29-14-30-22(18)33-9-11-34(12-10-33)23(35)31-15-5-7-16(8-6-15)36-24(26,27)28/h1-8,13-14H,9-12H2,(H,31,35)(H,29,30,32) URBLJLPZSXNERE-UHFFFAOYSA-N 368818 4-[6-(2-fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[4- (trifluoromethoxy)phenyl]piperazine-1- carboxamide::US10227357, Compound P-0067 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368818 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368818&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114464 402365618 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728797 CC1CN(CCN1C(=O)Nc1ccccc1)c1ncnc2[nH]c(cc12)-c1ccncc1 368819 2-methyl-N-phenyl-4-[6-(4-pyridyl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]piperazine-1- carboxamide::US10227357, Compound P-0068 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368819 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368819&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115035 402365619 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728798 CC1CN(CCN1C(=O)Nc1ccccc1)c1ncnc2[nH]c(cc12)-c1ccncc1 368819 2-methyl-N-phenyl-4-[6-(4-pyridyl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]piperazine-1- carboxamide::US10227357, Compound P-0068 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368819 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368819&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115035 402365619 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728799 COc1cccc(c1)[C@H](C)NC(=O)N1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(cc1)C#N 368820 4-[6-(4-cyanophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[(1S)-1-(3- methoxyphenyl)ethyl]piperazine-1- carboxamide::US10227357, Compound P-0069 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368820 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368820&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114248 402365620 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728800 CN(C)c1ccc(NC(=O)N2CCN(CC2)c2ncnc3[nH]c(cc23)-c2ccc(cc2)C#N)cc1 InChI=1S/C26H26N8O/c1-32(2)21-9-7-20(8-10-21)30-26(35)34-13-11-33(12-14-34)25-22-15-23(31-24(22)28-17-29-25)19-5-3-18(16-27)4-6-19/h3-10,15,17H,11-14H2,1-2H3,(H,30,35)(H,28,29,31) SECULNVIFPBTSP-UHFFFAOYSA-N 368821 4-[6-(4-cyanophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-(4- dimethylaminophenyl)piperazine-1- carboxamide::US10227357, Compound P-0070 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368821 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368821&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115085 402365621 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728801 CN(C)c1ccc(NC(=O)N2CCN(CC2)c2ncnc3[nH]c(cc23)-c2ccc(cc2)C#N)cc1 InChI=1S/C26H26N8O/c1-32(2)21-9-7-20(8-10-21)30-26(35)34-13-11-33(12-14-34)25-22-15-23(31-24(22)28-17-29-25)19-5-3-18(16-27)4-6-19/h3-10,15,17H,11-14H2,1-2H3,(H,30,35)(H,28,29,31) SECULNVIFPBTSP-UHFFFAOYSA-N 368821 4-[6-(4-cyanophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-(4- dimethylaminophenyl)piperazine-1- carboxamide::US10227357, Compound P-0070 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368821 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368821&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115085 402365621 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728802 C[C@H]1CN(CCN1)c1ncnc2[nH]c(cc12)-c1ccncc1 368822 4-[(3S)-3-methylpiperazin-1-yl]-6-(4-pyridyl)- 7H-pyrrolo[2,3-d]pyrimidine::US10227357, Compound P-0071 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368822 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368822&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114867 402365622 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728803 C[C@H]1CN(CCN1)c1ncnc2[nH]c(cc12)-c1ccncc1 368822 4-[(3S)-3-methylpiperazin-1-yl]-6-(4-pyridyl)- 7H-pyrrolo[2,3-d]pyrimidine::US10227357, Compound P-0071 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368822 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368822&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114867 402365622 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728804 C[C@H](NC(=O)N1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1)c1cccc(OC(F)F)c1 368823 N-[(1S)-1-[3-(difluoromethoxy)phenyl]ethyl]- 4-[6-(4-fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]piperazine-1-carboxamide::US10227357, Compound P-0072 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368823 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368823&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115181 402365623 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728805 C[C@H](NC(=O)N1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1)c1cccc(OC(F)F)c1 368823 N-[(1S)-1-[3-(difluoromethoxy)phenyl]ethyl]- 4-[6-(4-fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]piperazine-1-carboxamide::US10227357, Compound P-0072 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368823 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368823&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115181 402365623 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728806 FC(F)Oc1cccc(CNC(=O)N2CCN(CC2)c2ncnc3[nH]c(cc23)-c2ccc(F)cc2)c1 InChI=1S/C25H23F3N6O2/c26-18-6-4-17(5-7-18)21-13-20-22(32-21)30-15-31-23(20)33-8-10-34(11-9-33)25(35)29-14-16-2-1-3-19(12-16)36-24(27)28/h1-7,12-13,15,24H,8-11,14H2,(H,29,35)(H,30,31,32) YLBRDINOJIJPOS-UHFFFAOYSA-N 368824 N-[[3-(difluoromethoxy)phenyl]methyl]-4-[6- (4-fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidin- 4-yl]piperazine-1-carboxamide::US10227357, Compound P-0073 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368824 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368824&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114287 402365624 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728807 C[C@@H]1CN(CCN1)c1ncnc2[nH]c(cc12)-c1ccncc1 368825 4-[(3R)-3-methylpiperazin-1-yl]-6-(4-pyridyl)- 7H-pyrrolo[2,3-d]pyrimidine::US10227357, Compound P-0074 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368825 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368825&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90001310 402365625 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728808 C[C@@H]1CN(CCN1)c1ncnc2[nH]c(cc12)-c1ccncc1 368825 4-[(3R)-3-methylpiperazin-1-yl]-6-(4-pyridyl)- 7H-pyrrolo[2,3-d]pyrimidine::US10227357, Compound P-0074 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368825 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368825&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90001310 402365625 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728809 C[C@H](NC(=O)N1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1)c1cccc(OC(F)(F)F)c1 368826 4-[6-(4-fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[(1S)-1-[3- (trifluoromethoxy)phenyl]lethyl]piperazine-1- carboxamide::US10227357, Compound P-0075 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368826 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368826&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90137096 402365626 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728810 C[C@H](NC(=O)N1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1)c1cccc(OC(F)(F)F)c1 368826 4-[6-(4-fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[(1S)-1-[3- (trifluoromethoxy)phenyl]lethyl]piperazine-1- carboxamide::US10227357, Compound P-0075 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368826 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368826&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90137096 402365626 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728811 Fc1ccc(cc1)-c1cc2c(ncnc2[nH]1)N1CCN(CC1)C(=O)NCc1cccc(OC(F)(F)F)c1 InChI=1S/C25H22F4N6O2/c26-18-6-4-17(5-7-18)21-13-20-22(33-21)31-15-32-23(20)34-8-10-35(11-9-34)24(36)30-14-16-2-1-3-19(12-16)37-25(27,28)29/h1-7,12-13,15H,8-11,14H2,(H,30,36)(H,31,32,33) MQUJAJYCMPMXIX-UHFFFAOYSA-N 368827 4-[6-(4-fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[[3- (trifluoromethoxy)phenyl]methyl]piperazine- 1-carboxamide::US10227357, Compound P-0076 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368827 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368827&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114685 402365627 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728812 CS(=O)(=O)Nc1ccc(cc1)-c1cc2c(ncnc2[nH]1)N1CCN(CC1)C(=O)Nc1ccc(OC(F)(F)F)cc1 InChI=1S/C25H24F3N7O4S/c1-40(37,38)33-18-4-2-16(3-5-18)21-14-20-22(32-21)29-15-30-23(20)34-10-12-35(13-11-34)24(36)31-17-6-8-19(9-7-17)39-25(26,27)28/h2-9,14-15,33H,10-13H2,1H3,(H,31,36)(H,29,30,32) LEOMCJGMTVVVHI-UHFFFAOYSA-N 368828 4-[6-[4-(methanesulfonamido)phenyl]-7H- pyrrolo[2,3-d]pyrimidin-4-yl]-N-[4- (trifluoromethoxy)phenyl]piperazine-1- carboxamide::US10227357, Compound P-0077 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368828 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368828&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90137118 402365628 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728813 CS(=O)(=O)Nc1ccc(cc1)-c1cc2c(ncnc2[nH]1)N1CCN(CC1)C(=O)Nc1ccc(OC(F)(F)F)cc1 InChI=1S/C25H24F3N7O4S/c1-40(37,38)33-18-4-2-16(3-5-18)21-14-20-22(32-21)29-15-30-23(20)34-10-12-35(13-11-34)24(36)31-17-6-8-19(9-7-17)39-25(26,27)28/h2-9,14-15,33H,10-13H2,1H3,(H,31,36)(H,29,30,32) LEOMCJGMTVVVHI-UHFFFAOYSA-N 368828 4-[6-[4-(methanesulfonamido)phenyl]-7H- pyrrolo[2,3-d]pyrimidin-4-yl]-N-[4- (trifluoromethoxy)phenyl]piperazine-1- carboxamide::US10227357, Compound P-0077 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368828 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368828&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90137118 402365628 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728814 NC(=O)c1cccc(c1)-c1cc2c(ncnc2[nH]1)N1CCN(CC1)C(=O)Nc1ccc(OC(F)(F)F)cc1 InChI=1S/C25H22F3N7O3/c26-25(27,28)38-18-6-4-17(5-7-18)32-24(37)35-10-8-34(9-11-35)23-19-13-20(33-22(19)30-14-31-23)15-2-1-3-16(12-15)21(29)36/h1-7,12-14H,8-11H2,(H2,29,36)(H,32,37)(H,30,31,33) WDHMHAZQTCWKLM-UHFFFAOYSA-N 368829 4-[6-(3-carbamoylphenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[4- (trifluoromethoxy)phenyl]piperazine-1- carboxamide::US10227357, Compound P-0078 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368829 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368829&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114046 402365629 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728815 NC(=O)c1cccc(c1)-c1cc2c(ncnc2[nH]1)N1CCN(CC1)C(=O)Nc1ccc(OC(F)(F)F)cc1 InChI=1S/C25H22F3N7O3/c26-25(27,28)38-18-6-4-17(5-7-18)32-24(37)35-10-8-34(9-11-35)23-19-13-20(33-22(19)30-14-31-23)15-2-1-3-16(12-15)21(29)36/h1-7,12-14H,8-11H2,(H2,29,36)(H,32,37)(H,30,31,33) WDHMHAZQTCWKLM-UHFFFAOYSA-N 368829 4-[6-(3-carbamoylphenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[4- (trifluoromethoxy)phenyl]piperazine-1- carboxamide::US10227357, Compound P-0078 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368829 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368829&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114046 402365629 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728816 Cc1ncc(s1)-c1cc2c(ncnc2[nH]1)N1CCN(CC1)C(=O)NCc1ccc(F)cc1 InChI=1S/C22H22FN7OS/c1-14-24-12-19(32-14)18-10-17-20(28-18)26-13-27-21(17)29-6-8-30(9-7-29)22(31)25-11-15-2-4-16(23)5-3-15/h2-5,10,12-13H,6-9,11H2,1H3,(H,25,31)(H,26,27,28) AUXXIGOUPDDXLC-UHFFFAOYSA-N 368830 N-[(4-fluorophenyl)methyl]-4-[6-(2- methylthiazol-5-yl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]piperazine-1-carboxamide::US10227357, Compound P-0079 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368830 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368830&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90001219 402365630 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728817 Cc1ncc(s1)-c1cc2c(ncnc2[nH]1)N1CCN(CC1)C(=O)NCc1ccc(F)cc1 InChI=1S/C22H22FN7OS/c1-14-24-12-19(32-14)18-10-17-20(28-18)26-13-27-21(17)29-6-8-30(9-7-29)22(31)25-11-15-2-4-16(23)5-3-15/h2-5,10,12-13H,6-9,11H2,1H3,(H,25,31)(H,26,27,28) AUXXIGOUPDDXLC-UHFFFAOYSA-N 368830 N-[(4-fluorophenyl)methyl]-4-[6-(2- methylthiazol-5-yl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]piperazine-1-carboxamide::US10227357, Compound P-0079 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368830 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368830&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90001219 402365630 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728818 Cc1ncc(s1)-c1cc2c(ncnc2[nH]1)N1CCN(CC1)C(=O)Nc1ccc(OC(F)(F)F)cc1 InChI=1S/C22H20F3N7O2S/c1-13-26-11-18(35-13)17-10-16-19(30-17)27-12-28-20(16)31-6-8-32(9-7-31)21(33)29-14-2-4-15(5-3-14)34-22(23,24)25/h2-5,10-12H,6-9H2,1H3,(H,29,33)(H,27,28,30) XEEOJFVOOZEIRE-UHFFFAOYSA-N 368831 4-[6-(2-methylthiazol-5-yl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[4- (trifluoromethoxy)phenyl]piperazine-1- carboxamide::US10227357, Compound P-0080 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368831 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368831&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115099 402365631 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728819 Cc1ncc(s1)-c1cc2c(ncnc2[nH]1)N1CCN(CC1)C(=O)Nc1ccc(OC(F)(F)F)cc1 InChI=1S/C22H20F3N7O2S/c1-13-26-11-18(35-13)17-10-16-19(30-17)27-12-28-20(16)31-6-8-32(9-7-31)21(33)29-14-2-4-15(5-3-14)34-22(23,24)25/h2-5,10-12H,6-9H2,1H3,(H,29,33)(H,27,28,30) XEEOJFVOOZEIRE-UHFFFAOYSA-N 368831 4-[6-(2-methylthiazol-5-yl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[4- (trifluoromethoxy)phenyl]piperazine-1- carboxamide::US10227357, Compound P-0080 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368831 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368831&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115099 402365631 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728820 CNC(=O)c1cccc(c1)-c1cc2c(ncnc2[nH]1)N1CCN(CC1)C(=O)NCc1ccc(F)cc1 InChI=1S/C26H26FN7O2/c1-28-25(35)19-4-2-3-18(13-19)22-14-21-23(32-22)30-16-31-24(21)33-9-11-34(12-10-33)26(36)29-15-17-5-7-20(27)8-6-17/h2-8,13-14,16H,9-12,15H2,1H3,(H,28,35)(H,29,36)(H,30,31,32) KPZHQCUSOQAHFQ-UHFFFAOYSA-N 368832 N-[(4-fluorophenyl)rnethyl]-4-[6-[3- (methylcarbamoyl)phenyl]-7H-pyrrolo[2,3- d]pyrimidin-4-yl]piperazine-1-carboxamide::US10227357, Compound P-0081 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368832 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368832&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90137142 402365632 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728821 CNC(=O)c1cccc(c1)-c1cc2c(ncnc2[nH]1)N1CCN(CC1)C(=O)NCc1ccc(F)cc1 InChI=1S/C26H26FN7O2/c1-28-25(35)19-4-2-3-18(13-19)22-14-21-23(32-22)30-16-31-24(21)33-9-11-34(12-10-33)26(36)29-15-17-5-7-20(27)8-6-17/h2-8,13-14,16H,9-12,15H2,1H3,(H,28,35)(H,29,36)(H,30,31,32) KPZHQCUSOQAHFQ-UHFFFAOYSA-N 368832 N-[(4-fluorophenyl)rnethyl]-4-[6-[3- (methylcarbamoyl)phenyl]-7H-pyrrolo[2,3- d]pyrimidin-4-yl]piperazine-1-carboxamide::US10227357, Compound P-0081 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368832 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368832&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90137142 402365632 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728822 CC(=O)Nc1cccc(c1)-c1cc2c(ncnc2[nH]1)N1CCN(CC1)C(=O)NCc1ccc(F)cc1 InChI=1S/C26H26FN7O2/c1-17(35)31-21-4-2-3-19(13-21)23-14-22-24(32-23)29-16-30-25(22)33-9-11-34(12-10-33)26(36)28-15-18-5-7-20(27)8-6-18/h2-8,13-14,16H,9-12,15H2,1H3,(H,28,36)(H,31,35)(H,29,30,32) RFZOJZUGDPBAGI-UHFFFAOYSA-N 368833 4-[6-(3-acetamidophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[(4- fluorophenyl)methyl]piperazine-1- carboxamide::US10227357, Compound P-0082 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368833 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368833&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114236 402365633 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728823 CC(=O)Nc1cccc(c1)-c1cc2c(ncnc2[nH]1)N1CCN(CC1)C(=O)NCc1ccc(F)cc1 InChI=1S/C26H26FN7O2/c1-17(35)31-21-4-2-3-19(13-21)23-14-22-24(32-23)29-16-30-25(22)33-9-11-34(12-10-33)26(36)28-15-18-5-7-20(27)8-6-18/h2-8,13-14,16H,9-12,15H2,1H3,(H,28,36)(H,31,35)(H,29,30,32) RFZOJZUGDPBAGI-UHFFFAOYSA-N 368833 4-[6-(3-acetamidophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[(4- fluorophenyl)methyl]piperazine-1- carboxamide::US10227357, Compound P-0082 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368833 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368833&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114236 402365633 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728824 NS(=O)(=O)c1cccc(c1)-c1cc2c(ncnc2[nH]1)N1CCN(CC1)C(=O)Nc1ccc(OC(F)(F)F)cc1 InChI=1S/C24H22F3N7O4S/c25-24(26,27)38-17-6-4-16(5-7-17)31-23(35)34-10-8-33(9-11-34)22-19-13-20(32-21(19)29-14-30-22)15-2-1-3-18(12-15)39(28,36)37/h1-7,12-14H,8-11H2,(H,31,35)(H2,28,36,37)(H,29,30,32) UFRKHCQQFZROCP-UHFFFAOYSA-N 368834 4-[6-(3-sulfamoylphenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[4- (trifluoromethoxy)phenyl]piperazine-1- carboxamide::US10227357, Compound P-0083 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368834 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368834&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114598 402365634 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728825 NS(=O)(=O)c1cccc(c1)-c1cc2c(ncnc2[nH]1)N1CCN(CC1)C(=O)Nc1ccc(OC(F)(F)F)cc1 InChI=1S/C24H22F3N7O4S/c25-24(26,27)38-17-6-4-16(5-7-17)31-23(35)34-10-8-33(9-11-34)22-19-13-20(32-21(19)29-14-30-22)15-2-1-3-18(12-15)39(28,36)37/h1-7,12-14H,8-11H2,(H,31,35)(H2,28,36,37)(H,29,30,32) UFRKHCQQFZROCP-UHFFFAOYSA-N 368834 4-[6-(3-sulfamoylphenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[4- (trifluoromethoxy)phenyl]piperazine-1- carboxamide::US10227357, Compound P-0083 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368834 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368834&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114598 402365634 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728826 CC(=O)Nc1ccc(cn1)-c1cc2c(ncnc2[nH]1)N1CCN(CC1)C(=O)Nc1ccc(OC(F)(F)F)cc1 InChI=1S/C25H23F3N8O3/c1-15(37)32-21-7-2-16(13-29-21)20-12-19-22(34-20)30-14-31-23(19)35-8-10-36(11-9-35)24(38)33-17-3-5-18(6-4-17)39-25(26,27)28/h2-7,12-14H,8-11H2,1H3,(H,33,38)(H,29,32,37)(H,30,31,34) AMBIIMOGPMMTSI-UHFFFAOYSA-N 368835 4-[6-(6-acetamido-3-pyridyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[4- (trifluoromethoxy)phenyl]piperazine-1- carboxamide::US10227357, Compound P-0084 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368835 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368835&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114933 402365635 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728827 CC(=O)Nc1ccc(cn1)-c1cc2c(ncnc2[nH]1)N1CCN(CC1)C(=O)Nc1ccc(OC(F)(F)F)cc1 InChI=1S/C25H23F3N8O3/c1-15(37)32-21-7-2-16(13-29-21)20-12-19-22(34-20)30-14-31-23(19)35-8-10-36(11-9-35)24(38)33-17-3-5-18(6-4-17)39-25(26,27)28/h2-7,12-14H,8-11H2,1H3,(H,33,38)(H,29,32,37)(H,30,31,34) AMBIIMOGPMMTSI-UHFFFAOYSA-N 368835 4-[6-(6-acetamido-3-pyridyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[4- (trifluoromethoxy)phenyl]piperazine-1- carboxamide::US10227357, Compound P-0084 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368835 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368835&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114933 402365635 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728828 CN(C)C(=O)c1cccc(c1)-c1cc2c(ncnc2[nH]1)N1CCN(CC1)C(=O)Nc1ccc(OC(F)(F)F)cc1 InChI=1S/C27H26F3N7O3/c1-35(2)25(38)18-5-3-4-17(14-18)22-15-21-23(34-22)31-16-32-24(21)36-10-12-37(13-11-36)26(39)33-19-6-8-20(9-7-19)40-27(28,29)30/h3-9,14-16H,10-13H2,1-2H3,(H,33,39)(H,31,32,34) VLUBBVVJGPSOOO-UHFFFAOYSA-N 368836 4-[6-[3-(dimethylcarbamoyl)phenyl]-7H- pyrrolo[2,3-d]pyrimidin-4-yl]-N-[4- (trifluoromethoxy)phenyl]piperazine-1- carboxamide::US10227357, Compound P-0085 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368836 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368836&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114803 402365636 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728829 CN(C)C(=O)c1cccc(c1)-c1cc2c(ncnc2[nH]1)N1CCN(CC1)C(=O)Nc1ccc(OC(F)(F)F)cc1 InChI=1S/C27H26F3N7O3/c1-35(2)25(38)18-5-3-4-17(14-18)22-15-21-23(34-22)31-16-32-24(21)36-10-12-37(13-11-36)26(39)33-19-6-8-20(9-7-19)40-27(28,29)30/h3-9,14-16H,10-13H2,1-2H3,(H,33,39)(H,31,32,34) VLUBBVVJGPSOOO-UHFFFAOYSA-N 368836 4-[6-[3-(dimethylcarbamoyl)phenyl]-7H- pyrrolo[2,3-d]pyrimidin-4-yl]-N-[4- (trifluoromethoxy)phenyl]piperazine-1- carboxamide::US10227357, Compound P-0085 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368836 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368836&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114803 402365636 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728830 FC(F)(F)Oc1ccc(NC(=O)N2CCN(CC2)c2ncnc3[nH]c(cc23)-c2ccc(cc2)C#N)cc1 InChI=1S/C25H20F3N7O2/c26-25(27,28)37-19-7-5-18(6-8-19)32-24(36)35-11-9-34(10-12-35)23-20-13-21(33-22(20)30-15-31-23)17-3-1-16(14-29)2-4-17/h1-8,13,15H,9-12H2,(H,32,36)(H,30,31,33) YBUMZEGGMQRZMX-UHFFFAOYSA-N 368837 4-[6-(4-cyanophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[4- (trifluoromethoxy)phenyl]piperazine-1- carboxamide::US10227357, Compound P-0086 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368837 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368837&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115042 402365637 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728831 FC(F)(F)Oc1ccc(NC(=O)N2CCN(CC2)c2ncnc3[nH]c(cc23)-c2ccc(cc2)C#N)cc1 InChI=1S/C25H20F3N7O2/c26-25(27,28)37-19-7-5-18(6-8-19)32-24(36)35-11-9-34(10-12-35)23-20-13-21(33-22(20)30-15-31-23)17-3-1-16(14-29)2-4-17/h1-8,13,15H,9-12H2,(H,32,36)(H,30,31,33) YBUMZEGGMQRZMX-UHFFFAOYSA-N 368837 4-[6-(4-cyanophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[4- (trifluoromethoxy)phenyl]piperazine-1- carboxamide::US10227357, Compound P-0086 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368837 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368837&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115042 402365637 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728832 COc1ncc(CNC(=O)N2CCN(CC2)c2ncnc3[nH]c(cc23)-c2ccc(F)cc2)cc1F InChI=1S/C24H23F2N7O2/c1-35-23-19(26)10-15(12-27-23)13-28-24(34)33-8-6-32(7-9-33)22-18-11-20(31-21(18)29-14-30-22)16-2-4-17(25)5-3-16/h2-5,10-12,14H,6-9,13H2,1H3,(H,28,34)(H,29,30,31) CVAKFWMBBBJPCA-UHFFFAOYSA-N 368838 N-[(5-fluoro-6-methoxy-3-pyridyl)methyl]-4- [6-(4-fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]piperazine-1-carboxamide::US10227357, Compound P-0087 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368838 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368838&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114672 402365638 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728833 COc1ncc(CNC(=O)N2CCN(CC2)c2ncnc3[nH]c(cc23)-c2ccc(F)cc2)cc1F InChI=1S/C24H23F2N7O2/c1-35-23-19(26)10-15(12-27-23)13-28-24(34)33-8-6-32(7-9-33)22-18-11-20(31-21(18)29-14-30-22)16-2-4-17(25)5-3-16/h2-5,10-12,14H,6-9,13H2,1H3,(H,28,34)(H,29,30,31) CVAKFWMBBBJPCA-UHFFFAOYSA-N 368838 N-[(5-fluoro-6-methoxy-3-pyridyl)methyl]-4- [6-(4-fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]piperazine-1-carboxamide::US10227357, Compound P-0087 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368838 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368838&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114672 402365638 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728834 CCNC(=O)N1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 InChI=1S/C19H21FN6O/c1-2-21-19(27)26-9-7-25(8-10-26)18-15-11-16(24-17(15)22-12-23-18)13-3-5-14(20)6-4-13/h3-6,11-12H,2,7-10H2,1H3,(H,21,27)(H,22,23,24) MJQVSVYPEBCDOL-UHFFFAOYSA-N 368839 N-ethyl-4-[6-(4-fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]piperazine-1-carboxamide::US10227357, Compound P-0088 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368839 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368839&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115186 402365639 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728835 CCOc1ccc(NC(=O)N2CCN(CC2)c2ncnc3[nH]c(cc23)C#C)cc1 InChI=1S/C21H22N6O2/c1-3-15-13-18-19(24-15)22-14-23-20(18)26-9-11-27(12-10-26)21(28)25-16-5-7-17(8-6-16)29-4-2/h1,5-8,13-14H,4,9-12H2,2H3,(H,25,28)(H,22,23,24) RCTWFOAGIPHERB-UHFFFAOYSA-N 368840 N-(4-ethoxyphenyl)-4-(6-ethynyl-7H- pyrrolo[2,3-d]pyrimidin-4-yl)piperazine-1- carboxamide::US10227357, Compound P-0089 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368840 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368840&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115461 402365640 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728836 CCOc1ccc(NC(=O)N2CCN(CC2)c2ncnc3[nH]c(cc23)C#C)cc1 InChI=1S/C21H22N6O2/c1-3-15-13-18-19(24-15)22-14-23-20(18)26-9-11-27(12-10-26)21(28)25-16-5-7-17(8-6-16)29-4-2/h1,5-8,13-14H,4,9-12H2,2H3,(H,25,28)(H,22,23,24) RCTWFOAGIPHERB-UHFFFAOYSA-N 368840 N-(4-ethoxyphenyl)-4-(6-ethynyl-7H- pyrrolo[2,3-d]pyrimidin-4-yl)piperazine-1- carboxamide::US10227357, Compound P-0089 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368840 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368840&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115461 402365640 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728837 Fc1ccc(CNC(=O)N2CCN(CC2)c2ncnc3[nH]c(cc23)-c2ccc(F)cc2)cc1 InChI=1S/C24H22F2N6O/c25-18-5-1-16(2-6-18)14-27-24(33)32-11-9-31(10-12-32)23-20-13-21(30-22(20)28-15-29-23)17-3-7-19(26)8-4-17/h1-8,13,15H,9-12,14H2,(H,27,33)(H,28,29,30) IBUBXEVTJVCGPS-UHFFFAOYSA-N 368841 N-[(4-fluorophenyl)methyl]-4-[6-(4- fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]piperazine-1-carboxamide::US10227357, Compound P-0090 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368841 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368841&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114848 402365641 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728838 Cn1cc(cn1)-c1cc2c(ncnc2[nH]1)N1CCN(CC1)C(=O)Nc1ccc(OC(F)F)cc1 InChI=1S/C22H22F2N8O2/c1-30-12-14(11-27-30)18-10-17-19(29-18)25-13-26-20(17)31-6-8-32(9-7-31)22(33)28-15-2-4-16(5-3-15)34-21(23)24/h2-5,10-13,21H,6-9H2,1H3,(H,28,33)(H,25,26,29) HYVLHSCQKWIWDS-UHFFFAOYSA-N 368842 N-[4-(difluoromethoxy)phenyl]-4-[6-(1- methylpyrazol-4-yl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]piperazine-1-carboxamide::US10227357, Compound P-0091 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368842 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368842&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114084 402365642 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728839 Cn1cc(cn1)-c1cc2c(ncnc2[nH]1)N1CCN(CC1)C(=O)Nc1ccc(OC(F)F)cc1 InChI=1S/C22H22F2N8O2/c1-30-12-14(11-27-30)18-10-17-19(29-18)25-13-26-20(17)31-6-8-32(9-7-31)22(33)28-15-2-4-16(5-3-15)34-21(23)24/h2-5,10-13,21H,6-9H2,1H3,(H,28,33)(H,25,26,29) HYVLHSCQKWIWDS-UHFFFAOYSA-N 368842 N-[4-(difluoromethoxy)phenyl]-4-[6-(1- methylpyrazol-4-yl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]piperazine-1-carboxamide::US10227357, Compound P-0091 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368842 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368842&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114084 402365642 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728840 Cn1cc(cn1)-c1cc2c(ncnc2[nH]1)N1CCN(CC1)C(=O)Nc1ccc(OC(F)(F)F)cc1 InChI=1S/C22H21F3N8O2/c1-31-12-14(11-28-31)18-10-17-19(30-18)26-13-27-20(17)32-6-8-33(9-7-32)21(34)29-15-2-4-16(5-3-15)35-22(23,24)25/h2-5,10-13H,6-9H2,1H3,(H,29,34)(H,26,27,30) LUJFKRVABWXGMF-UHFFFAOYSA-N 368843 4-[6-(1-methylpyrazol-4-yl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[4- (trifluoromethoxy)phenyl]piperazine-1- carboxamide::US10227357, Compound P-0092 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368843 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368843&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114516 402365643 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728841 Cn1cc(cn1)-c1cc2c(ncnc2[nH]1)N1CCN(CC1)C(=O)Nc1ccc(OC(F)(F)F)cc1 InChI=1S/C22H21F3N8O2/c1-31-12-14(11-28-31)18-10-17-19(30-18)26-13-27-20(17)32-6-8-33(9-7-32)21(34)29-15-2-4-16(5-3-15)35-22(23,24)25/h2-5,10-13H,6-9H2,1H3,(H,29,34)(H,26,27,30) LUJFKRVABWXGMF-UHFFFAOYSA-N 368843 4-[6-(1-methylpyrazol-4-yl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[4- (trifluoromethoxy)phenyl]piperazine-1- carboxamide::US10227357, Compound P-0092 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368843 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368843&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114516 402365643 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728842 COc1cccc(c1)[C@H](C)NC(=O)N1CCN(CC1)c1ncnc2[nH]c(cc12)-c1cnn(C)c1 368844 N-[(1S)-1-(3-methoxyphenyl)ethyl]-4-[6-(1- methylpyrazol-4-yl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]piperazine-1-carboxamide::US10227357, Compound P-0093 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368844 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368844&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115104 402365644 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728843 COc1cccc(c1)[C@H](C)NC(=O)N1CCN(CC1)c1ncnc2[nH]c(cc12)-c1cnn(C)c1 368844 N-[(1S)-1-(3-methoxyphenyl)ethyl]-4-[6-(1- methylpyrazol-4-yl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]piperazine-1-carboxamide::US10227357, Compound P-0093 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368844 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368844&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115104 402365644 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728844 C[C@H](NC(=O)N1CCN(CC1)c1ncnc2[nH]c(cc12)-c1cnn(C)c1)c1ccc(F)cc1 368845 N-[(1S)-1-(4-fluorophenyl)ethyl]-4-[6-(1- methylpyrazol-4-yl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]piperazine-1-carboxamide::US10227357, Compound P-0094 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368845 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368845&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114799 402365645 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728845 C[C@H](NC(=O)N1CCN(CC1)c1ncnc2[nH]c(cc12)-c1cnn(C)c1)c1ccc(F)cc1 368845 N-[(1S)-1-(4-fluorophenyl)ethyl]-4-[6-(1- methylpyrazol-4-yl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]piperazine-1-carboxamide::US10227357, Compound P-0094 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368845 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368845&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114799 402365645 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728846 C[C@H](NC(=O)N1CCN(CC1)c1ncnc2[nH]c(cc12)-c1cnn(C)c1)c1ccc(Cl)cc1 368846 N-[(1S)-1-(4-chlorophenyl)ethyl]-4-[6-(1- methylpyrazol-4-yl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]piperazine-1-carboxamide::US10227357, Compound P-0095 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368846 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368846&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114229 402365646 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728847 C[C@H](NC(=O)N1CCN(CC1)c1ncnc2[nH]c(cc12)-c1cnn(C)c1)c1ccc(Cl)cc1 368846 N-[(1S)-1-(4-chlorophenyl)ethyl]-4-[6-(1- methylpyrazol-4-yl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]piperazine-1-carboxamide::US10227357, Compound P-0095 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368846 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368846&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114229 402365646 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728848 Cn1cc(cn1)-c1cc2c(ncnc2[nH]1)N1CCN(CC1)C(=O)Nc1ccc(F)cc1 InChI=1S/C21H21FN8O/c1-28-12-14(11-25-28)18-10-17-19(27-18)23-13-24-20(17)29-6-8-30(9-7-29)21(31)26-16-4-2-15(22)3-5-16/h2-5,10-13H,6-9H2,1H3,(H,26,31)(H,23,24,27) MFDKJSSNXCJMAR-UHFFFAOYSA-N 368847 N-(4-fluorophenyl)-4-[6-(1-methylpyrazol-4- yl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]piperazine-1-carboxamide::US10227357, Compound P-0096 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368847 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368847&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114481 402365647 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728849 Cn1cc(cn1)-c1cc2c(ncnc2[nH]1)N1CCN(CC1)C(=O)Nc1ccc(F)cc1 InChI=1S/C21H21FN8O/c1-28-12-14(11-25-28)18-10-17-19(27-18)23-13-24-20(17)29-6-8-30(9-7-29)21(31)26-16-4-2-15(22)3-5-16/h2-5,10-13H,6-9H2,1H3,(H,26,31)(H,23,24,27) MFDKJSSNXCJMAR-UHFFFAOYSA-N 368847 N-(4-fluorophenyl)-4-[6-(1-methylpyrazol-4- yl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]piperazine-1-carboxamide::US10227357, Compound P-0096 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368847 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368847&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114481 402365647 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728850 Cn1cc(cn1)-c1cc2c(ncnc2[nH]1)N1CCN(CC1)C(=O)NCc1ccc(Cl)cc1 InChI=1S/C22H23ClN8O/c1-29-13-16(12-27-29)19-10-18-20(28-19)25-14-26-21(18)30-6-8-31(9-7-30)22(32)24-11-15-2-4-17(23)5-3-15/h2-5,10,12-14H,6-9,11H2,1H3,(H,24,32)(H,25,26,28) APFYPUJMBRDNJJ-UHFFFAOYSA-N 368848 N-[(4-chlorophenyl)methyl]-4-[6-(1- methylpyrazol-4-yl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]piperazine-1-carboxamide::US10227357, Compound P-0097 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368848 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368848&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114596 402365648 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728851 Cn1cc(cn1)-c1cc2c(ncnc2[nH]1)N1CCN(CC1)C(=O)NCc1ccc(Cl)cc1 InChI=1S/C22H23ClN8O/c1-29-13-16(12-27-29)19-10-18-20(28-19)25-14-26-21(18)30-6-8-31(9-7-30)22(32)24-11-15-2-4-17(23)5-3-15/h2-5,10,12-14H,6-9,11H2,1H3,(H,24,32)(H,25,26,28) APFYPUJMBRDNJJ-UHFFFAOYSA-N 368848 N-[(4-chlorophenyl)methyl]-4-[6-(1- methylpyrazol-4-yl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]piperazine-1-carboxamide::US10227357, Compound P-0097 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368848 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368848&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114596 402365648 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728852 Fc1ccc(cc1)-c1cc2c(ncnc2[nH]1)N1CCN(CC1)C(=O)NS(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C23H20ClFN6O3S/c24-16-3-7-18(8-4-16)35(33,34)29-23(32)31-11-9-30(10-12-31)22-19-13-20(28-21(19)26-14-27-22)15-1-5-17(25)6-2-15/h1-8,13-14H,9-12H2,(H,29,32)(H,26,27,28) NLPVFKLRIYSVAI-UHFFFAOYSA-N 368849 N-(4-chlorophenyl)sulfonyl-4-[6-(4- fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]piperazine-1-carboxamide::US10227357, Compound P-0098 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368849 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368849&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114699 402365649 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728853 Fc1ccc(cc1)-c1cc2c(ncnc2[nH]1)N1CCN(CC1)C(=O)NS(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C23H20ClFN6O3S/c24-16-3-7-18(8-4-16)35(33,34)29-23(32)31-11-9-30(10-12-31)22-19-13-20(28-21(19)26-14-27-22)15-1-5-17(25)6-2-15/h1-8,13-14H,9-12H2,(H,29,32)(H,26,27,28) NLPVFKLRIYSVAI-UHFFFAOYSA-N 368849 N-(4-chlorophenyl)sulfonyl-4-[6-(4- fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]piperazine-1-carboxamide::US10227357, Compound P-0098 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368849 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368849&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114699 402365649 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728854 NS(=O)(=O)c1ccc(cc1)-c1cc2c(ncnc2[nH]1)N1CCN(CC1)C(=O)NCc1ccc(F)cc1 InChI=1S/C24H24FN7O3S/c25-18-5-1-16(2-6-18)14-27-24(33)32-11-9-31(10-12-32)23-20-13-21(30-22(20)28-15-29-23)17-3-7-19(8-4-17)36(26,34)35/h1-8,13,15H,9-12,14H2,(H,27,33)(H2,26,34,35)(H,28,29,30) CSMLXPJQGBGWPU-UHFFFAOYSA-N 368850 N-[(4-fluorophenyl)methyl]-4-[6-(4- sulfamoylphenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]piperazine-1-carboxamide::US10227357, Compound P-0099 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368850 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368850&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114879 402365650 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728855 NS(=O)(=O)c1ccc(cc1)-c1cc2c(ncnc2[nH]1)N1CCN(CC1)C(=O)NCc1ccc(F)cc1 InChI=1S/C24H24FN7O3S/c25-18-5-1-16(2-6-18)14-27-24(33)32-11-9-31(10-12-32)23-20-13-21(30-22(20)28-15-29-23)17-3-7-19(8-4-17)36(26,34)35/h1-8,13,15H,9-12,14H2,(H,27,33)(H2,26,34,35)(H,28,29,30) CSMLXPJQGBGWPU-UHFFFAOYSA-N 368850 N-[(4-fluorophenyl)methyl]-4-[6-(4- sulfamoylphenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]piperazine-1-carboxamide::US10227357, Compound P-0099 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368850 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368850&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114879 402365650 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728856 NS(=O)(=O)c1ccc(cc1)-c1cc2c(ncnc2[nH]1)N1CCN(CC1)C(=O)Nc1ccc(OC(F)(F)F)cc1 InChI=1S/C24H22F3N7O4S/c25-24(26,27)38-17-5-3-16(4-6-17)31-23(35)34-11-9-33(10-12-34)22-19-13-20(32-21(19)29-14-30-22)15-1-7-18(8-2-15)39(28,36)37/h1-8,13-14H,9-12H2,(H,31,35)(H2,28,36,37)(H,29,30,32) CJJFVTLCZDLCTI-UHFFFAOYSA-N 368851 4-[6-(4-sulfamoylphenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[4- (trifluoromethoxy)phenyl]piperazine-1- carboxamide::US10227357, Compound P-0100 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368851 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368851&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114941 402365651 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728857 NS(=O)(=O)c1ccc(cc1)-c1cc2c(ncnc2[nH]1)N1CCN(CC1)C(=O)Nc1ccc(OC(F)(F)F)cc1 InChI=1S/C24H22F3N7O4S/c25-24(26,27)38-17-5-3-16(4-6-17)31-23(35)34-11-9-33(10-12-34)22-19-13-20(32-21(19)29-14-30-22)15-1-7-18(8-2-15)39(28,36)37/h1-8,13-14H,9-12H2,(H,31,35)(H2,28,36,37)(H,29,30,32) CJJFVTLCZDLCTI-UHFFFAOYSA-N 368851 4-[6-(4-sulfamoylphenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[4- (trifluoromethoxy)phenyl]piperazine-1- carboxamide::US10227357, Compound P-0100 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368851 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368851&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114941 402365651 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728858 Fc1ccc(CNC(=O)N2CCN(CC2)c2ncnc3[nH]c(cc23)-c2ccncc2)cc1 InChI=1S/C23H22FN7O/c24-18-3-1-16(2-4-18)14-26-23(32)31-11-9-30(10-12-31)22-19-13-20(17-5-7-25-8-6-17)29-21(19)27-15-28-22/h1-8,13,15H,9-12,14H2,(H,26,32)(H,27,28,29) RGMMSEPAKPNRRO-UHFFFAOYSA-N 368852 N-[(4-fluorophenyl)methyl]-4-[6-(4-pyridyl)- 7H-pyrrolo[2,3-d]pyrimidin-4-yl]piperazine-1- carboxamide::US10227357, Compound P-0101 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368852 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368852&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114737 402365652 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728859 Fc1ccc(CNC(=O)N2CCN(CC2)c2ncnc3[nH]c(cc23)-c2ccncc2)cc1 InChI=1S/C23H22FN7O/c24-18-3-1-16(2-4-18)14-26-23(32)31-11-9-30(10-12-31)22-19-13-20(17-5-7-25-8-6-17)29-21(19)27-15-28-22/h1-8,13,15H,9-12,14H2,(H,26,32)(H,27,28,29) RGMMSEPAKPNRRO-UHFFFAOYSA-N 368852 N-[(4-fluorophenyl)methyl]-4-[6-(4-pyridyl)- 7H-pyrrolo[2,3-d]pyrimidin-4-yl]piperazine-1- carboxamide::US10227357, Compound P-0101 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368852 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368852&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114737 402365652 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728860 FC(F)(F)Oc1ccc(NC(=O)N2CCN(CC2)c2ncnc3[nH]c(cc23)-c2ccncc2)cc1 InChI=1S/C23H20F3N7O2/c24-23(25,26)35-17-3-1-16(2-4-17)30-22(34)33-11-9-32(10-12-33)21-18-13-19(15-5-7-27-8-6-15)31-20(18)28-14-29-21/h1-8,13-14H,9-12H2,(H,30,34)(H,28,29,31) XZCNMBMXOWYSQZ-UHFFFAOYSA-N 368853 4-[6-(4-pyridyl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]-N-[4-(trifluoromethoxy)phenyl]piperazine- 1-carboxamide::US10227357, Compound P-0102 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368853 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368853&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114433 402365653 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728861 FC(F)(F)Oc1ccc(NC(=O)N2CCN(CC2)c2ncnc3[nH]c(cc23)-c2ccncc2)cc1 InChI=1S/C23H20F3N7O2/c24-23(25,26)35-17-3-1-16(2-4-17)30-22(34)33-11-9-32(10-12-33)21-18-13-19(15-5-7-27-8-6-15)31-20(18)28-14-29-21/h1-8,13-14H,9-12H2,(H,30,34)(H,28,29,31) XZCNMBMXOWYSQZ-UHFFFAOYSA-N 368853 4-[6-(4-pyridyl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]-N-[4-(trifluoromethoxy)phenyl]piperazine- 1-carboxamide::US10227357, Compound P-0102 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368853 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368853&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114433 402365653 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728862 Cc1ccc(cn1)-c1cc2c(ncnc2[nH]1)N1CCN(CC1)C(=O)NCc1ccc(F)cc1 InChI=1S/C24H24FN7O/c1-16-2-5-18(14-26-16)21-12-20-22(30-21)28-15-29-23(20)31-8-10-32(11-9-31)24(33)27-13-17-3-6-19(25)7-4-17/h2-7,12,14-15H,8-11,13H2,1H3,(H,27,33)(H,28,29,30) ZUIBOKKCXOECNX-UHFFFAOYSA-N 368854 N-[(4-fluorophenyl)methyl]-4-[6-(6-methyl-3- pyridyl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]piperazine-1-carboxamide::US10227357, Compound P-0103 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368854 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368854&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114405 402365654 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728863 Cc1ccc(cn1)-c1cc2c(ncnc2[nH]1)N1CCN(CC1)C(=O)NCc1ccc(F)cc1 InChI=1S/C24H24FN7O/c1-16-2-5-18(14-26-16)21-12-20-22(30-21)28-15-29-23(20)31-8-10-32(11-9-31)24(33)27-13-17-3-6-19(25)7-4-17/h2-7,12,14-15H,8-11,13H2,1H3,(H,27,33)(H,28,29,30) ZUIBOKKCXOECNX-UHFFFAOYSA-N 368854 N-[(4-fluorophenyl)methyl]-4-[6-(6-methyl-3- pyridyl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]piperazine-1-carboxamide::US10227357, Compound P-0103 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368854 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368854&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114405 402365654 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728864 COc1cc(ccn1)-c1cc2c(ncnc2[nH]1)N1CCN(CC1)C(=O)NCc1ccc(F)cc1 InChI=1S/C24H24FN7O2/c1-34-21-12-17(6-7-26-21)20-13-19-22(30-20)28-15-29-23(19)31-8-10-32(11-9-31)24(33)27-14-16-2-4-18(25)5-3-16/h2-7,12-13,15H,8-11,14H2,1H3,(H,27,33)(H,28,29,30) OHAMTIFVCDCBTM-UHFFFAOYSA-N 368855 N-[(4-fluorophenyl)methyl]-4-[6-(2-methoxy- 4-pyridyl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]piperazine-1-carboxamide::US10227357, Compound P-0104 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368855 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368855&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114487 402365655 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728865 COc1cc(ccn1)-c1cc2c(ncnc2[nH]1)N1CCN(CC1)C(=O)NCc1ccc(F)cc1 InChI=1S/C24H24FN7O2/c1-34-21-12-17(6-7-26-21)20-13-19-22(30-20)28-15-29-23(19)31-8-10-32(11-9-31)24(33)27-14-16-2-4-18(25)5-3-16/h2-7,12-13,15H,8-11,14H2,1H3,(H,27,33)(H,28,29,30) OHAMTIFVCDCBTM-UHFFFAOYSA-N 368855 N-[(4-fluorophenyl)methyl]-4-[6-(2-methoxy- 4-pyridyl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]piperazine-1-carboxamide::US10227357, Compound P-0104 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368855 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368855&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114487 402365655 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728866 NS(=O)(=O)c1cccc(c1)-c1cc2c(ncnc2[nH]1)N1CCN(CC1)C(=O)NCc1ccc(F)cc1 InChI=1S/C24H24FN7O3S/c25-18-6-4-16(5-7-18)14-27-24(33)32-10-8-31(9-11-32)23-20-13-21(30-22(20)28-15-29-23)17-2-1-3-19(12-17)36(26,34)35/h1-7,12-13,15H,8-11,14H2,(H,27,33)(H2,26,34,35)(H,28,29,30) MZWUDJSUYCXIMK-UHFFFAOYSA-N 368856 N-[(4-fluorophenyl)methyl]-4-[6-(3- sulfamoylphenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]piperazine-1-carboxamide::US10227357, Compound P-0105 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368856 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368856&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114796 402365656 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728867 NS(=O)(=O)c1cccc(c1)-c1cc2c(ncnc2[nH]1)N1CCN(CC1)C(=O)NCc1ccc(F)cc1 InChI=1S/C24H24FN7O3S/c25-18-6-4-16(5-7-18)14-27-24(33)32-10-8-31(9-11-32)23-20-13-21(30-22(20)28-15-29-23)17-2-1-3-19(12-17)36(26,34)35/h1-7,12-13,15H,8-11,14H2,(H,27,33)(H2,26,34,35)(H,28,29,30) MZWUDJSUYCXIMK-UHFFFAOYSA-N 368856 N-[(4-fluorophenyl)methyl]-4-[6-(3- sulfamoylphenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]piperazine-1-carboxamide::US10227357, Compound P-0105 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368856 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368856&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114796 402365656 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728868 COc1ncc(cn1)-c1cc2c(ncnc2[nH]1)N1CCN(CC1)C(=O)NCc1ccc(F)cc1 InChI=1S/C23H23FN8O2/c1-34-22-25-12-16(13-26-22)19-10-18-20(30-19)28-14-29-21(18)31-6-8-32(9-7-31)23(33)27-11-15-2-4-17(24)5-3-15/h2-5,10,12-14H,6-9,11H2,1H3,(H,27,33)(H,28,29,30) GSIGQICBLPIDMG-UHFFFAOYSA-N 368857 N-[(4-fluorophenyl)methyl]-4-[6-(2- methoxypyrimidin-5-yl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]piperazine-1-carboxamide::US10227357, Compound P-0106 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368857 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368857&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114294 402365657 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728869 COc1ncc(cn1)-c1cc2c(ncnc2[nH]1)N1CCN(CC1)C(=O)NCc1ccc(F)cc1 InChI=1S/C23H23FN8O2/c1-34-22-25-12-16(13-26-22)19-10-18-20(30-19)28-14-29-21(18)31-6-8-32(9-7-31)23(33)27-11-15-2-4-17(24)5-3-15/h2-5,10,12-14H,6-9,11H2,1H3,(H,27,33)(H,28,29,30) GSIGQICBLPIDMG-UHFFFAOYSA-N 368857 N-[(4-fluorophenyl)methyl]-4-[6-(2- methoxypyrimidin-5-yl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]piperazine-1-carboxamide::US10227357, Compound P-0106 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368857 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368857&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114294 402365657 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728870 CS(=O)(=O)Nc1cccc(c1)-c1cc2c(ncnc2[nH]1)N1CCN(CC1)C(=O)NCc1ccc(F)cc1 InChI=1S/C25H26FN7O3S/c1-37(35,36)31-20-4-2-3-18(13-20)22-14-21-23(30-22)28-16-29-24(21)32-9-11-33(12-10-32)25(34)27-15-17-5-7-19(26)8-6-17/h2-8,13-14,16,31H,9-12,15H2,1H3,(H,27,34)(H,28,29,30) LDIUQISEKWWRBJ-UHFFFAOYSA-N 368858 N-[(4-fluorophenyl)methyl]-4-[6-[3- (methanesulfonamido)phenyl]-7H- pyrrolo[2,3-d]pyrimidin-4-yl]piperazine-1- carboxamide::US10227357, Compound P-0107 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368858 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368858&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114110 402365658 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728871 CS(=O)(=O)Nc1cccc(c1)-c1cc2c(ncnc2[nH]1)N1CCN(CC1)C(=O)NCc1ccc(F)cc1 InChI=1S/C25H26FN7O3S/c1-37(35,36)31-20-4-2-3-18(13-20)22-14-21-23(30-22)28-16-29-24(21)32-9-11-33(12-10-32)25(34)27-15-17-5-7-19(26)8-6-17/h2-8,13-14,16,31H,9-12,15H2,1H3,(H,27,34)(H,28,29,30) LDIUQISEKWWRBJ-UHFFFAOYSA-N 368858 N-[(4-fluorophenyl)methyl]-4-[6-[3- (methanesulfonamido)phenyl]-7H- pyrrolo[2,3-d]pyrimidin-4-yl]piperazine-1- carboxamide::US10227357, Compound P-0107 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368858 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368858&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114110 402365658 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728872 NC(=O)c1cccc(c1)-c1cc2c(ncnc2[nH]1)N1CCN(CC1)C(=O)NCc1ccc(F)cc1 InChI=1S/C25H24FN7O2/c26-19-6-4-16(5-7-19)14-28-25(35)33-10-8-32(9-11-33)24-20-13-21(31-23(20)29-15-30-24)17-2-1-3-18(12-17)22(27)34/h1-7,12-13,15H,8-11,14H2,(H2,27,34)(H,28,35)(H,29,30,31) SGSKOZZGGMJYJC-UHFFFAOYSA-N 368859 4-[6-(3-carbamoylphenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[(4- fluorophenyl)methyl]piperazine-1- carboxamide::US10227357, Compound P-0108 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368859 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368859&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114681 402365659 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728873 NC(=O)c1cccc(c1)-c1cc2c(ncnc2[nH]1)N1CCN(CC1)C(=O)NCc1ccc(F)cc1 InChI=1S/C25H24FN7O2/c26-19-6-4-16(5-7-19)14-28-25(35)33-10-8-32(9-11-33)24-20-13-21(31-23(20)29-15-30-24)17-2-1-3-18(12-17)22(27)34/h1-7,12-13,15H,8-11,14H2,(H2,27,34)(H,28,35)(H,29,30,31) SGSKOZZGGMJYJC-UHFFFAOYSA-N 368859 4-[6-(3-carbamoylphenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[(4- fluorophenyl)methyl]piperazine-1- carboxamide::US10227357, Compound P-0108 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368859 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368859&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114681 402365659 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728874 Fc1ccc(CNC(=O)N2CCN(CC2)c2ncnc3[nH]c(cc23)-c2ccc(cc2)C#N)cc1 InChI=1S/C25H22FN7O/c26-20-7-3-18(4-8-20)15-28-25(34)33-11-9-32(10-12-33)24-21-13-22(31-23(21)29-16-30-24)19-5-1-17(14-27)2-6-19/h1-8,13,16H,9-12,15H2,(H,28,34)(H,29,30,31) YOPOUXHOMZEMLX-UHFFFAOYSA-N 368860 4-[6-(4-cyanophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[(4- fluorophenyl)methyl]piperazine-1- carboxamide::US10227357, Compound P-0109 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368860 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368860&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114939 402365660 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728875 Fc1ccc(CNC(=O)N2CCN(CC2)c2ncnc3[nH]c(cc23)-c2ccc(cc2)C#N)cc1 InChI=1S/C25H22FN7O/c26-20-7-3-18(4-8-20)15-28-25(34)33-11-9-32(10-12-33)24-21-13-22(31-23(21)29-16-30-24)19-5-1-17(14-27)2-6-19/h1-8,13,16H,9-12,15H2,(H,28,34)(H,29,30,31) YOPOUXHOMZEMLX-UHFFFAOYSA-N 368860 4-[6-(4-cyanophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[(4- fluorophenyl)methyl]piperazine-1- carboxamide::US10227357, Compound P-0109 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368860 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368860&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114939 402365660 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728876 Fc1ccc(CNC(=O)N2CCN(CC2)c2ncnc3[nH]c(cc23)-c2cccc(c2)C#N)cc1 InChI=1S/C25H22FN7O/c26-20-6-4-17(5-7-20)15-28-25(34)33-10-8-32(9-11-33)24-21-13-22(31-23(21)29-16-30-24)19-3-1-2-18(12-19)14-27/h1-7,12-13,16H,8-11,15H2,(H,28,34)(H,29,30,31) NWKKTBQDWBYBBP-UHFFFAOYSA-N 368861 4-[6-(3-cyanophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[(4- fluorophenyl)methyl]piperazine-1- carboxamide::US10227357, Compound P-0110 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368861 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368861&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115366 402365661 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728877 Fc1ccc(CNC(=O)N2CCN(CC2)c2ncnc3[nH]c(cc23)-c2cccc(c2)C#N)cc1 InChI=1S/C25H22FN7O/c26-20-6-4-17(5-7-20)15-28-25(34)33-10-8-32(9-11-33)24-21-13-22(31-23(21)29-16-30-24)19-3-1-2-18(12-19)14-27/h1-7,12-13,16H,8-11,15H2,(H,28,34)(H,29,30,31) NWKKTBQDWBYBBP-UHFFFAOYSA-N 368861 4-[6-(3-cyanophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[(4- fluorophenyl)methyl]piperazine-1- carboxamide::US10227357, Compound P-0110 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368861 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368861&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115366 402365661 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728878 FC(F)(F)Oc1ccc(NC(=O)N2CCN(CC2)c2ncnc3[nH]c(cc23)-c2ccc(nc2)C2CC2)cc1 InChI=1S/C26H24F3N7O2/c27-26(28,29)38-19-6-4-18(5-7-19)33-25(37)36-11-9-35(10-12-36)24-20-13-22(34-23(20)31-15-32-24)17-3-8-21(30-14-17)16-1-2-16/h3-8,13-16H,1-2,9-12H2,(H,33,37)(H,31,32,34) ZLUVQPUUWDLFHZ-UHFFFAOYSA-N 368862 4-[6-(6-cyclopropyl-3-pyridyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[4- (trifluoromethoxy)phenyl]piperazine-1- carboxamide::US10227357, Compound P-0111 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368862 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368862&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115420 402365662 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728879 FC(F)(F)Oc1ccc(NC(=O)N2CCN(CC2)c2ncnc3[nH]c(cc23)-c2ccc(nc2)C2CC2)cc1 InChI=1S/C26H24F3N7O2/c27-26(28,29)38-19-6-4-18(5-7-19)33-25(37)36-11-9-35(10-12-36)24-20-13-22(34-23(20)31-15-32-24)17-3-8-21(30-14-17)16-1-2-16/h3-8,13-16H,1-2,9-12H2,(H,33,37)(H,31,32,34) ZLUVQPUUWDLFHZ-UHFFFAOYSA-N 368862 4-[6-(6-cyclopropyl-3-pyridyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[4- (trifluoromethoxy)phenyl]piperazine-1- carboxamide::US10227357, Compound P-0111 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368862 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368862&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115420 402365662 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728880 FC(F)(F)Oc1ccc(NC(=O)N2CCN(CC2)c2ncnc3[nH]c(cc23)-c2cnc(nc2)C2CC2)cc1 InChI=1S/C25H23F3N8O2/c26-25(27,28)38-18-5-3-17(4-6-18)33-24(37)36-9-7-35(8-10-36)23-19-11-20(34-22(19)31-14-32-23)16-12-29-21(30-13-16)15-1-2-15/h3-6,11-15H,1-2,7-10H2,(H,33,37)(H,31,32,34) HSIYMWXIDXWQAH-UHFFFAOYSA-N 368863 4-[6-(2-cyclopropylpyrimidin-5-yl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]-N-[4- (trifluoromethoxy)phenyl]piperazine-1- carboxamide::US10227357, Compound P-0112 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368863 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368863&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115077 402365663 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728881 FC(F)(F)Oc1ccc(NC(=O)N2CCN(CC2)c2ncnc3[nH]c(cc23)-c2cnc(nc2)C2CC2)cc1 InChI=1S/C25H23F3N8O2/c26-25(27,28)38-18-5-3-17(4-6-18)33-24(37)36-9-7-35(8-10-36)23-19-11-20(34-22(19)31-14-32-23)16-12-29-21(30-13-16)15-1-2-15/h3-6,11-15H,1-2,7-10H2,(H,33,37)(H,31,32,34) HSIYMWXIDXWQAH-UHFFFAOYSA-N 368863 4-[6-(2-cyclopropylpyrimidin-5-yl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]-N-[4- (trifluoromethoxy)phenyl]piperazine-1- carboxamide::US10227357, Compound P-0112 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368863 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368863&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115077 402365663 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728882 FC(F)(F)Oc1ccc(NC(=O)N2CCN(CC2)c2ncnc3[nH]c(cc23)-c2ccc(cc2)C2(CC2)C#N)cc1 InChI=1S/C28H24F3N7O2/c29-28(30,31)40-21-7-5-20(6-8-21)35-26(39)38-13-11-37(12-14-38)25-22-15-23(36-24(22)33-17-34-25)18-1-3-19(4-2-18)27(16-32)9-10-27/h1-8,15,17H,9-14H2,(H,35,39)(H,33,34,36) BMRQUTVFHFEMRE-UHFFFAOYSA-N 368864 4-[6-[4-(1-cyanocyclopropyl)phenyl]-7H- pyrrolo[2,3-d]pyrimidin-4-yl]-N-[4- (trifluoromethoxy)phenyl]piperazine-1- carboxamide::US10227357, Compound P-0113 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368864 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368864&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115039 402365664 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728883 FC(F)(F)Oc1ccc(NC(=O)N2CCN(CC2)c2ncnc3[nH]c(cc23)-c2ccc(cc2)C2(CC2)C#N)cc1 InChI=1S/C28H24F3N7O2/c29-28(30,31)40-21-7-5-20(6-8-21)35-26(39)38-13-11-37(12-14-38)25-22-15-23(36-24(22)33-17-34-25)18-1-3-19(4-2-18)27(16-32)9-10-27/h1-8,15,17H,9-14H2,(H,35,39)(H,33,34,36) BMRQUTVFHFEMRE-UHFFFAOYSA-N 368864 4-[6-[4-(1-cyanocyclopropyl)phenyl]-7H- pyrrolo[2,3-d]pyrimidin-4-yl]-N-[4- (trifluoromethoxy)phenyl]piperazine-1- carboxamide::US10227357, Compound P-0113 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368864 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368864&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115039 402365664 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728884 CN(C)c1ccc(cn1)-c1cc2c(ncnc2[nH]1)N1CCN(CC1)C(=O)Nc1ccc(OC(F)(F)F)cc1 InChI=1S/C25H25F3N8O2/c1-34(2)21-8-3-16(14-29-21)20-13-19-22(33-20)30-15-31-23(19)35-9-11-36(12-10-35)24(37)32-17-4-6-18(7-5-17)38-25(26,27)28/h3-8,13-15H,9-12H2,1-2H3,(H,32,37)(H,30,31,33) LUMVLDQNLDWDGU-UHFFFAOYSA-N 368865 4-[6-[6-(dimethylamino)-3-pyridyl]-7H- pyrrolo[2,3-d]pyrimidin-4-yl]-N-[4- (trifluoromethoxy)phenyl]piperazine-1- carboxamide::US10227357, Compound P-0114 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368865 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368865&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114641 402365665 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728885 CN(C)c1ccc(cn1)-c1cc2c(ncnc2[nH]1)N1CCN(CC1)C(=O)Nc1ccc(OC(F)(F)F)cc1 InChI=1S/C25H25F3N8O2/c1-34(2)21-8-3-16(14-29-21)20-13-19-22(33-20)30-15-31-23(19)35-9-11-36(12-10-35)24(37)32-17-4-6-18(7-5-17)38-25(26,27)28/h3-8,13-15H,9-12H2,1-2H3,(H,32,37)(H,30,31,33) LUMVLDQNLDWDGU-UHFFFAOYSA-N 368865 4-[6-[6-(dimethylamino)-3-pyridyl]-7H- pyrrolo[2,3-d]pyrimidin-4-yl]-N-[4- (trifluoromethoxy)phenyl]piperazine-1- carboxamide::US10227357, Compound P-0114 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368865 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368865&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114641 402365665 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728886 Cc1ccc(cn1)-c1cc2c(ncnc2[nH]1)N1CCN(CC1)C(=O)Nc1ccc(OC(F)(F)F)cc1 InChI=1S/C24H22F3N7O2/c1-15-2-3-16(13-28-15)20-12-19-21(32-20)29-14-30-22(19)33-8-10-34(11-9-33)23(35)31-17-4-6-18(7-5-17)36-24(25,26)27/h2-7,12-14H,8-11H2,1H3,(H,31,35)(H,29,30,32) KJKJKBPHSJGKFN-UHFFFAOYSA-N 368866 4-[6-(6-methyl-3-pyridyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[4- (trifluoromethoxy)phenyl]piperazine-1- carboxamide::US10227357, Compound P-0115 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368866 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368866&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114564 402365666 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728887 Cc1ccc(cn1)-c1cc2c(ncnc2[nH]1)N1CCN(CC1)C(=O)Nc1ccc(OC(F)(F)F)cc1 InChI=1S/C24H22F3N7O2/c1-15-2-3-16(13-28-15)20-12-19-21(32-20)29-14-30-22(19)33-8-10-34(11-9-33)23(35)31-17-4-6-18(7-5-17)36-24(25,26)27/h2-7,12-14H,8-11H2,1H3,(H,31,35)(H,29,30,32) KJKJKBPHSJGKFN-UHFFFAOYSA-N 368866 4-[6-(6-methyl-3-pyridyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[4- (trifluoromethoxy)phenyl]piperazine-1- carboxamide::US10227357, Compound P-0115 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368866 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368866&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114564 402365666 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728888 CNC(=O)c1cccc(c1)-c1cc2c(ncnc2[nH]1)N1CCN(CC1)C(=O)Nc1ccc(OC(F)(F)F)cc1 InChI=1S/C26H24F3N7O3/c1-30-24(37)17-4-2-3-16(13-17)21-14-20-22(34-21)31-15-32-23(20)35-9-11-36(12-10-35)25(38)33-18-5-7-19(8-6-18)39-26(27,28)29/h2-8,13-15H,9-12H2,1H3,(H,30,37)(H,33,38)(H,31,32,34) HCYUHPXGJQQNAB-UHFFFAOYSA-N 368867 4-[6-[3-(methylcarbamoyl)phenyl]-7H- pyrrolo[2,3-d]pyrimidin-4-yl]-N-[4- (trifluoromethoxy)phenyl]piperazine-1- carboxamide::US10227357, Compound P-0116 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368867 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368867&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114840 402365667 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728889 CNC(=O)c1cccc(c1)-c1cc2c(ncnc2[nH]1)N1CCN(CC1)C(=O)Nc1ccc(OC(F)(F)F)cc1 InChI=1S/C26H24F3N7O3/c1-30-24(37)17-4-2-3-16(13-17)21-14-20-22(34-21)31-15-32-23(20)35-9-11-36(12-10-35)25(38)33-18-5-7-19(8-6-18)39-26(27,28)29/h2-8,13-15H,9-12H2,1H3,(H,30,37)(H,33,38)(H,31,32,34) HCYUHPXGJQQNAB-UHFFFAOYSA-N 368867 4-[6-[3-(methylcarbamoyl)phenyl]-7H- pyrrolo[2,3-d]pyrimidin-4-yl]-N-[4- (trifluoromethoxy)phenyl]piperazine-1- carboxamide::US10227357, Compound P-0116 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368867 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368867&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114840 402365667 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728890 COc1cc(ccn1)-c1cc2c(ncnc2[nH]1)N1CCN(CC1)C(=O)Nc1ccc(OC(F)(F)F)cc1 InChI=1S/C24H22F3N7O3/c1-36-20-12-15(6-7-28-20)19-13-18-21(32-19)29-14-30-22(18)33-8-10-34(11-9-33)23(35)31-16-2-4-17(5-3-16)37-24(25,26)27/h2-7,12-14H,8-11H2,1H3,(H,31,35)(H,29,30,32) MXAPOQIBVPXISQ-UHFFFAOYSA-N 368868 4-[6-(2-methoxy-4-pyridyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[4- (trifluoromethoxy)phenyl]piperazine-1- carboxamide::US10227357, Compound P-0117 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368868 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368868&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115115 402365668 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728891 COc1cc(ccn1)-c1cc2c(ncnc2[nH]1)N1CCN(CC1)C(=O)Nc1ccc(OC(F)(F)F)cc1 InChI=1S/C24H22F3N7O3/c1-36-20-12-15(6-7-28-20)19-13-18-21(32-19)29-14-30-22(18)33-8-10-34(11-9-33)23(35)31-16-2-4-17(5-3-16)37-24(25,26)27/h2-7,12-14H,8-11H2,1H3,(H,31,35)(H,29,30,32) MXAPOQIBVPXISQ-UHFFFAOYSA-N 368868 4-[6-(2-methoxy-4-pyridyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[4- (trifluoromethoxy)phenyl]piperazine-1- carboxamide::US10227357, Compound P-0117 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368868 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368868&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115115 402365668 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728892 COc1ccc(cn1)-c1cc2c(ncnc2[nH]1)N1CCN(CC1)C(=O)Nc1ccc(OC(F)(F)F)cc1 InChI=1S/C24H22F3N7O3/c1-36-20-7-2-15(13-28-20)19-12-18-21(32-19)29-14-30-22(18)33-8-10-34(11-9-33)23(35)31-16-3-5-17(6-4-16)37-24(25,26)27/h2-7,12-14H,8-11H2,1H3,(H,31,35)(H,29,30,32) YNUBOLBJUBIMLC-UHFFFAOYSA-N 368869 4-[6-(6-methoxy-3-pyridyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[4- (trifluoromethoxy)phenyl]piperazine-1- carboxamide::US10227357, Compound P-0118 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368869 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368869&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114540 402365669 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728893 COc1ccc(cn1)-c1cc2c(ncnc2[nH]1)N1CCN(CC1)C(=O)Nc1ccc(OC(F)(F)F)cc1 InChI=1S/C24H22F3N7O3/c1-36-20-7-2-15(13-28-20)19-12-18-21(32-19)29-14-30-22(18)33-8-10-34(11-9-33)23(35)31-16-3-5-17(6-4-16)37-24(25,26)27/h2-7,12-14H,8-11H2,1H3,(H,31,35)(H,29,30,32) YNUBOLBJUBIMLC-UHFFFAOYSA-N 368869 4-[6-(6-methoxy-3-pyridyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[4- (trifluoromethoxy)phenyl]piperazine-1- carboxamide::US10227357, Compound P-0118 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368869 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368869&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114540 402365669 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728894 CS(=O)(=O)Nc1cccc(c1)-c1cc2c(ncnc2[nH]1)N1CCN(CC1)C(=O)Nc1ccc(OC(F)(F)F)cc1 InChI=1S/C25H24F3N7O4S/c1-40(37,38)33-18-4-2-3-16(13-18)21-14-20-22(32-21)29-15-30-23(20)34-9-11-35(12-10-34)24(36)31-17-5-7-19(8-6-17)39-25(26,27)28/h2-8,13-15,33H,9-12H2,1H3,(H,31,36)(H,29,30,32) JKZCQRHPCAKCIC-UHFFFAOYSA-N 368870 4-[6-[3-(methanesulfonamido)phenyl]-7H- pyrrolo[2,3-d]pyrimidin-4-yl]-N-[4- (trifluoromethoxy)phenyl]piperazine-1- carboxamide::US10227357, Compound P-0119 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368870 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368870&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114846 402365670 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728895 CS(=O)(=O)Nc1cccc(c1)-c1cc2c(ncnc2[nH]1)N1CCN(CC1)C(=O)Nc1ccc(OC(F)(F)F)cc1 InChI=1S/C25H24F3N7O4S/c1-40(37,38)33-18-4-2-3-16(13-18)21-14-20-22(32-21)29-15-30-23(20)34-9-11-35(12-10-34)24(36)31-17-5-7-19(8-6-17)39-25(26,27)28/h2-8,13-15,33H,9-12H2,1H3,(H,31,36)(H,29,30,32) JKZCQRHPCAKCIC-UHFFFAOYSA-N 368870 4-[6-[3-(methanesulfonamido)phenyl]-7H- pyrrolo[2,3-d]pyrimidin-4-yl]-N-[4- (trifluoromethoxy)phenyl]piperazine-1- carboxamide::US10227357, Compound P-0119 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368870 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368870&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114846 402365670 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728896 CC(=O)Nc1cccc(c1)-c1cc2c(ncnc2[nH]1)N1CCN(CC1)C(=O)Nc1ccc(OC(F)(F)F)cc1 InChI=1S/C26H24F3N7O3/c1-16(37)32-19-4-2-3-17(13-19)22-14-21-23(34-22)30-15-31-24(21)35-9-11-36(12-10-35)25(38)33-18-5-7-20(8-6-18)39-26(27,28)29/h2-8,13-15H,9-12H2,1H3,(H,32,37)(H,33,38)(H,30,31,34) QBIREWNKYSEUCC-UHFFFAOYSA-N 368871 4-[6-(3-acetamidophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[4- (trifluoromethoxy)phenyl]piperazine-1- carboxamide::US10227357, Compound P-0120 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368871 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368871&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115010 402365671 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728897 CC(=O)Nc1cccc(c1)-c1cc2c(ncnc2[nH]1)N1CCN(CC1)C(=O)Nc1ccc(OC(F)(F)F)cc1 InChI=1S/C26H24F3N7O3/c1-16(37)32-19-4-2-3-17(13-19)22-14-21-23(34-22)30-15-31-24(21)35-9-11-36(12-10-35)25(38)33-18-5-7-20(8-6-18)39-26(27,28)29/h2-8,13-15H,9-12H2,1H3,(H,32,37)(H,33,38)(H,30,31,34) QBIREWNKYSEUCC-UHFFFAOYSA-N 368871 4-[6-(3-acetamidophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[4- (trifluoromethoxy)phenyl]piperazine-1- carboxamide::US10227357, Compound P-0120 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368871 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368871&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115010 402365671 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728898 FC(F)(F)Oc1ccc(NC(=O)N2CCN(CC2)c2ncnc3[nH]c(cc23)-c2cccc(c2)C#N)cc1 InChI=1S/C25H20F3N7O2/c26-25(27,28)37-19-6-4-18(5-7-19)32-24(36)35-10-8-34(9-11-35)23-20-13-21(33-22(20)30-15-31-23)17-3-1-2-16(12-17)14-29/h1-7,12-13,15H,8-11H2,(H,32,36)(H,30,31,33) UIQCVAXVVMPCLL-UHFFFAOYSA-N 368872 4-[6-(3-cyanophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[4- (trifluoromethoxy)phenyl]piperazine-1- carboxamide::US10227357, Compound P-0121 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368872 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368872&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114335 402365672 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728899 FC(F)(F)Oc1ccc(NC(=O)N2CCN(CC2)c2ncnc3[nH]c(cc23)-c2cccc(c2)C#N)cc1 InChI=1S/C25H20F3N7O2/c26-25(27,28)37-19-6-4-18(5-7-19)32-24(36)35-10-8-34(9-11-35)23-20-13-21(33-22(20)30-15-31-23)17-3-1-2-16(12-17)14-29/h1-7,12-13,15H,8-11H2,(H,32,36)(H,30,31,33) UIQCVAXVVMPCLL-UHFFFAOYSA-N 368872 4-[6-(3-cyanophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[4- (trifluoromethoxy)phenyl]piperazine-1- carboxamide::US10227357, Compound P-0121 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368872 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368872&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114335 402365672 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728900 COc1cccc(CNC(=O)N2CCN(CC2)c2ncnc3[nH]c(cc23)-c2ccc(F)cc2)n1 InChI=1S/C24H24FN7O2/c1-34-21-4-2-3-18(29-21)14-26-24(33)32-11-9-31(10-12-32)23-19-13-20(30-22(19)27-15-28-23)16-5-7-17(25)8-6-16/h2-8,13,15H,9-12,14H2,1H3,(H,26,33)(H,27,28,30) DAKZKOJDOHXCCO-UHFFFAOYSA-N 368873 4-[6-(4-fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[(6-methoxy-2- pyridyl)methyl]piperazine-1-carboxamide::US10227357, Compound P-0122 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368873 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368873&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90001401 402365673 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728901 Clc1ccc(CNC(=O)N2CCN(CC2)c2ncnc3[nH]c(cc23)-c2cccnc2)nc1 InChI=1S/C22H21ClN8O/c23-16-3-4-17(25-12-16)13-26-22(32)31-8-6-30(7-9-31)21-18-10-19(15-2-1-5-24-11-15)29-20(18)27-14-28-21/h1-5,10-12,14H,6-9,13H2,(H,26,32)(H,27,28,29) WTRXSZCQUNACDD-UHFFFAOYSA-N 368874 N-[(5-chloro-2-pyridyl)methyl]-4-[6-(3- pyridyl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]piperazine-1-carboxamide::US10227357, Compound P-0123 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368874 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368874&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114902 402365674 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728902 Clc1ccc(CNC(=O)N2CCN(CC2)c2ncnc3[nH]c(cc23)-c2cccnc2)nc1 InChI=1S/C22H21ClN8O/c23-16-3-4-17(25-12-16)13-26-22(32)31-8-6-30(7-9-31)21-18-10-19(15-2-1-5-24-11-15)29-20(18)27-14-28-21/h1-5,10-12,14H,6-9,13H2,(H,26,32)(H,27,28,29) WTRXSZCQUNACDD-UHFFFAOYSA-N 368874 N-[(5-chloro-2-pyridyl)methyl]-4-[6-(3- pyridyl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]piperazine-1-carboxamide::US10227357, Compound P-0123 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368874 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368874&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114902 402365674 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728903 Fc1ccc(CNC(=O)N2CCN(CC2)c2ncnc3[nH]c(cc23)-c2cccnc2)nc1 InChI=1S/C22H21FN8O/c23-16-3-4-17(25-12-16)13-26-22(32)31-8-6-30(7-9-31)21-18-10-19(15-2-1-5-24-11-15)29-20(18)27-14-28-21/h1-5,10-12,14H,6-9,13H2,(H,26,32)(H,27,28,29) WHVIPMIYADWIBJ-UHFFFAOYSA-N 368875 N-[(5-fluoro-2-pyridyl)methyl]-4-[6-(3- pyridyl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]piperazine-1-carboxamide::US10227357, Compound P-0124 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368875 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368875&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114752 402365675 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728904 FC(F)Oc1ccc(NC(=O)N2CCN(CC2)c2ncnc3[nH]c(cc23)-c2ccc(F)cc2)cc1 InChI=1S/C24H21F3N6O2/c25-16-3-1-15(2-4-16)20-13-19-21(31-20)28-14-29-22(19)32-9-11-33(12-10-32)24(34)30-17-5-7-18(8-6-17)35-23(26)27/h1-8,13-14,23H,9-12H2,(H,30,34)(H,28,29,31) WIQBZVBAGXSZMS-UHFFFAOYSA-N 368876 N-[4-(difluoromethoxy)phenyl]-4-[6-(4- fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]piperazine-1-carboxamide::US10227357, Compound P-0125 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368876 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368876&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115508 402365676 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728905 FC(F)Oc1ccc(NC(=O)N2CCN(CC2)c2ncnc3[nH]c(cc23)-c2ccc(F)cc2)cc1 InChI=1S/C24H21F3N6O2/c25-16-3-1-15(2-4-16)20-13-19-21(31-20)28-14-29-22(19)32-9-11-33(12-10-32)24(34)30-17-5-7-18(8-6-17)35-23(26)27/h1-8,13-14,23H,9-12H2,(H,30,34)(H,28,29,31) WIQBZVBAGXSZMS-UHFFFAOYSA-N 368876 N-[4-(difluoromethoxy)phenyl]-4-[6-(4- fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]piperazine-1-carboxamide::US10227357, Compound P-0125 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368876 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368876&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115508 402365676 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728906 C[C@H](NC(=O)N1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1)c1ccc(F)cc1 368877 N-[(1S)-1-(4-fluorophenyl)ethyl]-4-[6-(4- fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]piperazine-1-carboxamide::US10227357, Compound P-0126 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368877 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368877&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114687 402365677 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728907 COc1cc(CNC(=O)N2CCN(CC2)c2ncnc3[nH]c(cc23)-c2cccnc2)ccn1 InChI=1S/C23H24N8O2/c1-33-20-11-16(4-6-25-20)13-26-23(32)31-9-7-30(8-10-31)22-18-12-19(17-3-2-5-24-14-17)29-21(18)27-15-28-22/h2-6,11-12,14-15H,7-10,13H2,1H3,(H,26,32)(H,27,28,29) VGHUZKJEPPMNGH-UHFFFAOYSA-N 368878 N-[(2-methoxy-4-pyridyl)methyl]-4-[6-(3- pyridyl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]piperazine-1-carboxamide::US10227357, Compound P-0127 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368878 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368878&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115043 402365678 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728908 COc1cc(CNC(=O)N2CCN(CC2)c2ncnc3[nH]c(cc23)-c2cccnc2)ccn1 InChI=1S/C23H24N8O2/c1-33-20-11-16(4-6-25-20)13-26-23(32)31-9-7-30(8-10-31)22-18-12-19(17-3-2-5-24-14-17)29-21(18)27-15-28-22/h2-6,11-12,14-15H,7-10,13H2,1H3,(H,26,32)(H,27,28,29) VGHUZKJEPPMNGH-UHFFFAOYSA-N 368878 N-[(2-methoxy-4-pyridyl)methyl]-4-[6-(3- pyridyl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]piperazine-1-carboxamide::US10227357, Compound P-0127 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368878 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368878&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115043 402365678 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728909 COc1cccc(CNC(=O)N2CCN(CC2)c2ncnc3[nH]c(cc23)-c2cccnc2)n1 InChI=1S/C23H24N8O2/c1-33-20-6-2-5-17(28-20)14-25-23(32)31-10-8-30(9-11-31)22-18-12-19(16-4-3-7-24-13-16)29-21(18)26-15-27-22/h2-7,12-13,15H,8-11,14H2,1H3,(H,25,32)(H,26,27,29) TZIQTEZBRULWSV-UHFFFAOYSA-N 368879 N-[(6-methoxy-2-pyridyl)methyl]-4-[6-(3- pyridyl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]piperazine-1-carboxamide::US10227357, Compound P-0128 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368879 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368879&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114824 402365679 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728910 COc1cccc(CNC(=O)N2CCN(CC2)c2ncnc3[nH]c(cc23)-c2cccnc2)n1 InChI=1S/C23H24N8O2/c1-33-20-6-2-5-17(28-20)14-25-23(32)31-10-8-30(9-11-31)22-18-12-19(16-4-3-7-24-13-16)29-21(18)26-15-27-22/h2-7,12-13,15H,8-11,14H2,1H3,(H,25,32)(H,26,27,29) TZIQTEZBRULWSV-UHFFFAOYSA-N 368879 N-[(6-methoxy-2-pyridyl)methyl]-4-[6-(3- pyridyl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]piperazine-1-carboxamide::US10227357, Compound P-0128 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368879 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368879&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114824 402365679 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728911 COc1ccc(CNC(=O)N2CCN(CC2)c2ncnc3[nH]c(cc23)-c2ccc(F)cc2)cn1 InChI=1S/C24H24FN7O2/c1-34-21-7-2-16(13-26-21)14-27-24(33)32-10-8-31(9-11-32)23-19-12-20(30-22(19)28-15-29-23)17-3-5-18(25)6-4-17/h2-7,12-13,15H,8-11,14H2,1H3,(H,27,33)(H,28,29,30) WUBDQZUMYCZGNG-UHFFFAOYSA-N 368880 4-[6-(4-fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[(6-methoxy-3- pyridyl)methyl]piperazine-1-carboxamide::US10227357, Compound P-0129 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368880&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115174 402365680 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728912 NC(=O)N1CCN(CC1)c1ncnc2[nH]c(cc12)-c1cccnc1 InChI=1S/C16H17N7O/c17-16(24)23-6-4-22(5-7-23)15-12-8-13(11-2-1-3-18-9-11)21-14(12)19-10-20-15/h1-3,8-10H,4-7H2,(H2,17,24)(H,19,20,21) UZEXEEVLSCKBCT-UHFFFAOYSA-N 368881 4-[6-(3-pyridyl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]piperazine-1-carboxamide::US10227357, Compound P-0130 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368881 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368881&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114308 402365681 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728913 NC(=O)N1CCN(CC1)c1ncnc2[nH]c(cc12)-c1cccnc1 InChI=1S/C16H17N7O/c17-16(24)23-6-4-22(5-7-23)15-12-8-13(11-2-1-3-18-9-11)21-14(12)19-10-20-15/h1-3,8-10H,4-7H2,(H2,17,24)(H,19,20,21) UZEXEEVLSCKBCT-UHFFFAOYSA-N 368881 4-[6-(3-pyridyl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]piperazine-1-carboxamide::US10227357, Compound P-0130 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368881 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368881&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114308 402365681 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728914 Fc1ccc(cc1)-c1cc2c(ncnc2[nH]1)N1CCN(CC1)C(=O)NCc1cncc(F)c1 InChI=1S/C23H21F2N7O/c24-17-3-1-16(2-4-17)20-10-19-21(30-20)28-14-29-22(19)31-5-7-32(8-6-31)23(33)27-12-15-9-18(25)13-26-11-15/h1-4,9-11,13-14H,5-8,12H2,(H,27,33)(H,28,29,30) ITLUXJFXAILQAK-UHFFFAOYSA-N 368882 4-[6-(4-fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[(5-fluoro-3- pyridyl)methyl]piperazine-1-carboxamide::US10227357, Compound P-0131 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368882 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368882&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115029 402365682 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728915 Fc1ccc(cc1)-c1cc2c(ncnc2[nH]1)N1CCN(CC1)C(=O)NCc1cncc(F)c1 InChI=1S/C23H21F2N7O/c24-17-3-1-16(2-4-17)20-10-19-21(30-20)28-14-29-22(19)31-5-7-32(8-6-31)23(33)27-12-15-9-18(25)13-26-11-15/h1-4,9-11,13-14H,5-8,12H2,(H,27,33)(H,28,29,30) ITLUXJFXAILQAK-UHFFFAOYSA-N 368882 4-[6-(4-fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[(5-fluoro-3- pyridyl)methyl]piperazine-1-carboxamide::US10227357, Compound P-0131 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368882 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368882&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115029 402365682 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728916 CN(C)c1ccc(NC(=O)N2CCN(CC2)c2ncnc3[nH]ccc23)cc1 InChI=1S/C19H23N7O/c1-24(2)15-5-3-14(4-6-15)23-19(27)26-11-9-25(10-12-26)18-16-7-8-20-17(16)21-13-22-18/h3-8,13H,9-12H2,1-2H3,(H,23,27)(H,20,21,22) PCHOZUOFPPNIIO-UHFFFAOYSA-N 368883 N-(4-dimethylaminophenyl)-4-(7H- pyrrolo[2,3-d]pyrimidin-4-yl)piperazine-1- carboxamide::US10227357, Compound P-0132 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368883 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368883&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114915 402365683 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728917 Fc1ccc(cc1)-c1cc2c(ncnc2[nH]1)N1CCN(CC1)C(=O)Nc1ccc(OC(F)(F)F)cc1 InChI=1S/C24H20F4N6O2/c25-16-3-1-15(2-4-16)20-13-19-21(32-20)29-14-30-22(19)33-9-11-34(12-10-33)23(35)31-17-5-7-18(8-6-17)36-24(26,27)28/h1-8,13-14H,9-12H2,(H,31,35)(H,29,30,32) GOPIQENBZCCMCV-UHFFFAOYSA-N 368884 4-[6-(4-fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[4- (trifluoromethoxy)phenyl]piperazine-1- carboxamide::US10227357, Compound P-0133 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368884 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368884&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114864 402365684 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728918 Fc1ccc(cc1)-c1cc2c(ncnc2[nH]1)N1CCN(CC1)C(=O)Nc1ccc(OC(F)(F)F)cc1 InChI=1S/C24H20F4N6O2/c25-16-3-1-15(2-4-16)20-13-19-21(32-20)29-14-30-22(19)33-9-11-34(12-10-33)23(35)31-17-5-7-18(8-6-17)36-24(26,27)28/h1-8,13-14H,9-12H2,(H,31,35)(H,29,30,32) GOPIQENBZCCMCV-UHFFFAOYSA-N 368884 4-[6-(4-fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[4- (trifluoromethoxy)phenyl]piperazine-1- carboxamide::US10227357, Compound P-0133 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368884 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368884&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114864 402365684 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728919 FC(F)(F)Oc1ccc(NC(=O)N2CCN(CC2)c2ncnc3[nH]c(cc23)-c2ccc(Cl)cc2)cc1 InChI=1S/C24H20ClF3N6O2/c25-16-3-1-15(2-4-16)20-13-19-21(32-20)29-14-30-22(19)33-9-11-34(12-10-33)23(35)31-17-5-7-18(8-6-17)36-24(26,27)28/h1-8,13-14H,9-12H2,(H,31,35)(H,29,30,32) GMYCJGKPJSFCSO-UHFFFAOYSA-N 368885 4-[6-(4-chlorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[4- (trifluoromethoxy)phenyl]piperazine-1- carboxamide::US10227357, Compound P-0134 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368885 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368885&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114432 402365685 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728920 FC(F)(F)Oc1ccc(NC(=O)N2CCN(CC2)c2ncnc3[nH]c(cc23)-c2ccc(Cl)cc2)cc1 InChI=1S/C24H20ClF3N6O2/c25-16-3-1-15(2-4-16)20-13-19-21(32-20)29-14-30-22(19)33-9-11-34(12-10-33)23(35)31-17-5-7-18(8-6-17)36-24(26,27)28/h1-8,13-14H,9-12H2,(H,31,35)(H,29,30,32) GMYCJGKPJSFCSO-UHFFFAOYSA-N 368885 4-[6-(4-chlorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[4- (trifluoromethoxy)phenyl]piperazine-1- carboxamide::US10227357, Compound P-0134 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368885 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368885&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114432 402365685 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728921 Fc1ccc(CNC(=O)N2CCN(CC2)c2ncnc3[nH]cc(CC4CC4)c23)cc1 InChI=1S/C22H25FN6O/c23-18-5-3-16(4-6-18)12-25-22(30)29-9-7-28(8-10-29)21-19-17(11-15-1-2-15)13-24-20(19)26-14-27-21/h3-6,13-15H,1-2,7-12H2,(H,25,30)(H,24,26,27) KOJLPNHGGWSZFX-UHFFFAOYSA-N 368886 4-[5-(cyclopropylmethyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[(4- fluorophenyl)methyl]piperazine-1- carboxamide::US10227357, Compound P-0137 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368886 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368886&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114444 402365686 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728922 Fc1ccc(CNC(=O)N2CCN(CC2)c2ncnc3[nH]cc(CC4CC4)c23)cc1 InChI=1S/C22H25FN6O/c23-18-5-3-16(4-6-18)12-25-22(30)29-9-7-28(8-10-29)21-19-17(11-15-1-2-15)13-24-20(19)26-14-27-21/h3-6,13-15H,1-2,7-12H2,(H,25,30)(H,24,26,27) KOJLPNHGGWSZFX-UHFFFAOYSA-N 368886 4-[5-(cyclopropylmethyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[(4- fluorophenyl)methyl]piperazine-1- carboxamide::US10227357, Compound P-0137 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368886 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368886&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114444 402365686 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728923 Clc1ccc(CNC(=O)N2CCN(CC2)c2ncnc3[nH]c(cc23)C2CC2)cc1 InChI=1S/C21H23ClN6O/c22-16-5-1-14(2-6-16)12-23-21(29)28-9-7-27(8-10-28)20-17-11-18(15-3-4-15)26-19(17)24-13-25-20/h1-2,5-6,11,13,15H,3-4,7-10,12H2,(H,23,29)(H,24,25,26) BAGBCLDRCLIKNS-UHFFFAOYSA-N 368887 N-[(4-chlorophenyl)methyl]-4-(6-cyclopropyl- 7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperazine-1- carboxamide::US10227357, Compound P-0138 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368887 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368887&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114581 402365687 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728924 Clc1cc2c(ncnc2[nH]1)N1CCN(CC1)C(=O)NCc1ccc(Cl)cc1 InChI=1S/C18H18Cl2N6O/c19-13-3-1-12(2-4-13)10-21-18(27)26-7-5-25(6-8-26)17-14-9-15(20)24-16(14)22-11-23-17/h1-4,9,11H,5-8,10H2,(H,21,27)(H,22,23,24) DIFAXRUCAVIPTR-UHFFFAOYSA-N 368888 N-[(4-chlorophenyl)methyl]-4-(6-chloro-7H- pyrrolo[2,3-d]pyrimidin-4-yl)piperazine-1- carboxamide::US10227357, Compound P-0139 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368888 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368888&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114764 402365688 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728925 COc1ncc(F)cc1CNC(=O)N1CCN(CC1)c1ncnc2[nH]c(cc12)-c1cccnc1 InChI=1S/C23H23FN8O2/c1-34-22-16(9-17(24)13-26-22)12-27-23(33)32-7-5-31(6-8-32)21-18-10-19(15-3-2-4-25-11-15)30-20(18)28-14-29-21/h2-4,9-11,13-14H,5-8,12H2,1H3,(H,27,33)(H,28,29,30) LIGNGEIHIDEWJR-UHFFFAOYSA-N 368889 N-[(5-fluoro-2-methoxy-3-pyridyl)methyl]-4- [6-(3-pyridyl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]piperazine-1-carboxamide::US10227357, Compound P-0140 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368889 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368889&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114706 402365689 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728926 Cc1ccc(NS(=O)(=O)N2CCN(CC2)c2ncnc3[nH]c(cc23)-c2ccc(Cl)cc2)cc1 InChI=1S/C23H23ClN6O2S/c1-16-2-8-19(9-3-16)28-33(31,32)30-12-10-29(11-13-30)23-20-14-21(27-22(20)25-15-26-23)17-4-6-18(24)7-5-17/h2-9,14-15,28H,10-13H2,1H3,(H,25,26,27) KPMRSBFHBKHIKC-UHFFFAOYSA-N 368890 4-[6-(4-chlorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-(p-tolyl)piperazine-1- sulfonamide::US10227357, Compound P-0142 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368890 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368890&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114841 402365690 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728927 Fc1ccc(cc1)-c1cc2c(ncnc2[nH]1)N1CCN(CC1)C(=O)NC(=O)c1ccccc1 InChI=1S/C24H21FN6O2/c25-18-8-6-16(7-9-18)20-14-19-21(28-20)26-15-27-22(19)30-10-12-31(13-11-30)24(33)29-23(32)17-4-2-1-3-5-17/h1-9,14-15H,10-13H2,(H,26,27,28)(H,29,32,33) QGNSDMZTRPCMCN-UHFFFAOYSA-N 368891 N-benzoyl-4-[6-(4-fluorophenyl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]piperazine-1- carboxamide::US10227357, Compound P-0143 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368891 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368891&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114834 402365691 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728928 COc1cccc(c1)[C@H](C)NC(=O)N1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 368767 4-[6-(4-fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[(1S)-1-[3- (trideuteriomethoxy)phenyl]ethyl]piperazine- 1-carboxamide::US10227357, Compound P-0015::US10227357, Compound P-0144 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368767 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368767&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114806 402365567 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728929 COc1cccc(c1)[C@H](C)NC(=O)N1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 368767 4-[6-(4-fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[(1S)-1-[3- (trideuteriomethoxy)phenyl]ethyl]piperazine- 1-carboxamide::US10227357, Compound P-0015::US10227357, Compound P-0144 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368767 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368767&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114806 402365567 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728930 COc1ccc(cc1)[C@@H](C)NC(=O)N1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 368893 4-[6-(4-fluorophenyl)-7H-pyrrolo[2,3- pyrimidin-4-yl]-N-[(1R)-1-(4- methoxyphenyl)ethyl]piperazine-1- carboxamide::US10227357, Compound P-0145 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368893 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368893&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90134757 402365692 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728931 C[C@@H](NC(=O)N1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1)c1ccc(F)cc1 368894 N-[(1R)-1-(4-fluorophenyl)ethyl]-4-[6-(4- fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]piperazine-1-carboxamide::US10227357, Compound P-0146 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368894 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368894&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115003 402365693 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728932 Fc1ccc(cc1)-c1cc2c(ncnc2[nH]1)N1CCN(CC1)C(=O)NC(=O)NC1CCCC1 InChI=1S/C23H26FN7O2/c24-16-7-5-15(6-8-16)19-13-18-20(28-19)25-14-26-21(18)30-9-11-31(12-10-30)23(33)29-22(32)27-17-3-1-2-4-17/h5-8,13-14,17H,1-4,9-12H2,(H,25,26,28)(H2,27,29,32,33) WBZUITSOXWGSNH-UHFFFAOYSA-N 368895 N-[(1R)-1-(4-fluorophenyl)ethyl]-4-[6-(4- fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]piperazine-1-carboxamide::US10227357, Compound P-0147 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368895 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368895&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90137117 402365694 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728933 COc1cccc(c1)[C@@H](C)NC(=O)N1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 368896 N-cyclopentyl-4-[6-(4-fluorophenyl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]piperazine-1- carboxamide::US10227357, Compound P-0148 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368896 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368896&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114557 402365695 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728934 Fc1ccc(CNC(=O)N2CCN(CC2)c2ncnc3[nH]c(cc23)C#N)cc1 InChI=1S/C19H18FN7O/c20-14-3-1-13(2-4-14)11-22-19(28)27-7-5-26(6-8-27)18-16-9-15(10-21)25-17(16)23-12-24-18/h1-4,9,12H,5-8,11H2,(H,22,28)(H,23,24,25) KPDKDDUCFVXDSO-UHFFFAOYSA-N 368897 4-[6-(4-fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[(1R)-1-(3- methoxyphenyl)ethyl]piperazine-1- carboxamide::US10227357, Compound P-0149 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368897 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368897&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90137122 402365696 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728935 Fc1ccc(CNC(=O)N2CCN(CC2)c2ncnc3[nH]c(cc23)C#N)cc1 InChI=1S/C19H18FN7O/c20-14-3-1-13(2-4-14)11-22-19(28)27-7-5-26(6-8-27)18-16-9-15(10-21)25-17(16)23-12-24-18/h1-4,9,12H,5-8,11H2,(H,22,28)(H,23,24,25) KPDKDDUCFVXDSO-UHFFFAOYSA-N 368897 4-[6-(4-fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[(1R)-1-(3- methoxyphenyl)ethyl]piperazine-1- carboxamide::US10227357, Compound P-0149 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368897 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368897&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90137122 402365696 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728936 Cc1nc(no1)-c1cccc(NC(=O)N2CCN(CC2)c2ncnc3[nH]ccc23)c1 InChI=1S/C20H20N8O2/c1-13-24-17(26-30-13)14-3-2-4-15(11-14)25-20(29)28-9-7-27(8-10-28)19-16-5-6-21-18(16)22-12-23-19/h2-6,11-12H,7-10H2,1H3,(H,25,29)(H,21,22,23) YSSNTXOBYPIQGO-UHFFFAOYSA-N 368898 4-(6-cyano-7H-pyrrolo[2,3-d]pyrimidin-4-yl)- N-[(4-fluorophenyl)rnethyl]piperazine-1- carboxamide::US10227357, Compound P-0150 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368898 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368898&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114705 402365697 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728937 Cc1nc(no1)-c1cccc(NC(=O)N2CCN(CC2)c2ncnc3[nH]ccc23)c1 InChI=1S/C20H20N8O2/c1-13-24-17(26-30-13)14-3-2-4-15(11-14)25-20(29)28-9-7-27(8-10-28)19-16-5-6-21-18(16)22-12-23-19/h2-6,11-12H,7-10H2,1H3,(H,25,29)(H,21,22,23) YSSNTXOBYPIQGO-UHFFFAOYSA-N 368898 4-(6-cyano-7H-pyrrolo[2,3-d]pyrimidin-4-yl)- N-[(4-fluorophenyl)rnethyl]piperazine-1- carboxamide::US10227357, Compound P-0150 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368898 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368898&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114705 402365697 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728938 O=C(Nc1cccnc1)N1CCN(CC1)c1ncnc2[nH]ccc12 InChI=1S/C16H17N7O/c24-16(21-12-2-1-4-17-10-12)23-8-6-22(7-9-23)15-13-3-5-18-14(13)19-11-20-15/h1-5,10-11H,6-9H2,(H,21,24)(H,18,19,20) RBVGWXKGRWSLNR-UHFFFAOYSA-N 368899 N-[3-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]- 4-(7H-pyrrolo[2,3-d]pyrimidin-4- yl)piperazine-1-carboxamide::US10227357, Compound P-0151 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368899 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368899&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114793 402365698 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728939 O=C(Nc1cccnc1)N1CCN(CC1)c1ncnc2[nH]ccc12 InChI=1S/C16H17N7O/c24-16(21-12-2-1-4-17-10-12)23-8-6-22(7-9-23)15-13-3-5-18-14(13)19-11-20-15/h1-5,10-11H,6-9H2,(H,21,24)(H,18,19,20) RBVGWXKGRWSLNR-UHFFFAOYSA-N 368899 N-[3-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]- 4-(7H-pyrrolo[2,3-d]pyrimidin-4- yl)piperazine-1-carboxamide::US10227357, Compound P-0151 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368899 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368899&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114793 402365698 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728940 Fc1ccc(cc1)-c1cc2c(ncnc2[nH]1)N1CCN(CC1)C(=O)NCc1ccc(Cl)cc1 InChI=1S/C24H22ClFN6O/c25-18-5-1-16(2-6-18)14-27-24(33)32-11-9-31(10-12-32)23-20-13-21(30-22(20)28-15-29-23)17-3-7-19(26)8-4-17/h1-8,13,15H,9-12,14H2,(H,27,33)(H,28,29,30) YSWMRYYPOZRMQV-UHFFFAOYSA-N 368900 N-(3-pyridyl)-4-(7H-pyrrolo[2,3-d]pyrimidin- 4-yl)piperazine-1-carboxamide::US10227357, Compound P-0152 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368900 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368900&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114307 402365699 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728941 Fc1ccc(cc1)-c1cc2c(ncnc2[nH]1)N1CCN(CC1)C(=O)NCc1ccccc1Cl InChI=1S/C24H22ClFN6O/c25-20-4-2-1-3-17(20)14-27-24(33)32-11-9-31(10-12-32)23-19-13-21(30-22(19)28-15-29-23)16-5-7-18(26)8-6-16/h1-8,13,15H,9-12,14H2,(H,27,33)(H,28,29,30) BTXUXOKRPBKKRW-UHFFFAOYSA-N 368901 N-[(4-chlorophenyl)methyl]-4-[6-(4- fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]piperazine-1-carboxamide::US10227357, Compound P-0153 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368901 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368901&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114935 402365700 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728942 C[C@H](NC(=O)N1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1)c1cccc2ccccc12 368902 N-[(2-chlorophenyl)methyl]-4-[6-(4- fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]piperazine-1-carboxamide::US10227357, Compound P-0154 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368902 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368902&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114862 402365701 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728943 C[C@H](NC(=O)N1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1)c1cccc2ccccc12 368902 N-[(2-chlorophenyl)methyl]-4-[6-(4- fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]piperazine-1-carboxamide::US10227357, Compound P-0154 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368902 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368902&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114862 402365701 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728944 COc1cccc(CNC(=O)N2CCN(CC2)c2ncnc3[nH]c(cc23)-c2ccc(F)cc2)c1 InChI=1S/C25H25FN6O2/c1-34-20-4-2-3-17(13-20)15-27-25(33)32-11-9-31(10-12-32)24-21-14-22(30-23(21)28-16-29-24)18-5-7-19(26)8-6-18/h2-8,13-14,16H,9-12,15H2,1H3,(H,27,33)(H,28,29,30) JEMCBSJYDUKGES-UHFFFAOYSA-N 368903 4-[6-(4-fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[(1S)-1-(1- naphthyl)ethyl]piperazine-1-carboxamide::US10227357, Compound P-0155 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368903 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368903&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114835 402365702 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728945 COc1cccc(CNC(=O)N2CCN(CC2)c2ncnc3[nH]c(cc23)-c2ccc(F)cc2)c1 InChI=1S/C25H25FN6O2/c1-34-20-4-2-3-17(13-20)15-27-25(33)32-11-9-31(10-12-32)24-21-14-22(30-23(21)28-16-29-24)18-5-7-19(26)8-6-18/h2-8,13-14,16H,9-12,15H2,1H3,(H,27,33)(H,28,29,30) JEMCBSJYDUKGES-UHFFFAOYSA-N 368903 4-[6-(4-fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[(1S)-1-(1- naphthyl)ethyl]piperazine-1-carboxamide::US10227357, Compound P-0155 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368903 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368903&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114835 402365702 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728946 COc1ccc(CNC(=O)N2CCN(CC2)c2ncnc3[nH]c(cc23)-c2ccc(F)cc2)cc1 InChI=1S/C25H25FN6O2/c1-34-20-8-2-17(3-9-20)15-27-25(33)32-12-10-31(11-13-32)24-21-14-22(30-23(21)28-16-29-24)18-4-6-19(26)7-5-18/h2-9,14,16H,10-13,15H2,1H3,(H,27,33)(H,28,29,30) AVVXFPCXVOEUPC-UHFFFAOYSA-N 368904 4-[6-(4-fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[(3- methoxyphenyl)methyl]piperazine-1- carboxamide::US10227357, Compound P-0156 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368904 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368904&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114215 402365703 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728947 COc1ccc(CNC(=O)N2CCN(CC2)c2ncnc3[nH]c(cc23)-c2ccc(F)cc2)cc1 InChI=1S/C25H25FN6O2/c1-34-20-8-2-17(3-9-20)15-27-25(33)32-12-10-31(11-13-32)24-21-14-22(30-23(21)28-16-29-24)18-4-6-19(26)7-5-18/h2-9,14,16H,10-13,15H2,1H3,(H,27,33)(H,28,29,30) AVVXFPCXVOEUPC-UHFFFAOYSA-N 368904 4-[6-(4-fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[(3- methoxyphenyl)methyl]piperazine-1- carboxamide::US10227357, Compound P-0156 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368904 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368904&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114215 402365703 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728948 Fc1ccc(CNC(=O)N2CCN(CC2)c2ncnc3[nH]cc(C#N)c23)cc1 InChI=1S/C19H18FN7O/c20-15-3-1-13(2-4-15)10-23-19(28)27-7-5-26(6-8-27)18-16-14(9-21)11-22-17(16)24-12-25-18/h1-4,11-12H,5-8,10H2,(H,23,28)(H,22,24,25) RBALINMSAIGBPA-UHFFFAOYSA-N 368905 4-[6-(4-fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[(4- methoxyphenyl)methyl]piperazine-1- carboxamide::US10227357, Compound P-0157 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368905 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368905&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114521 402365704 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728949 Fc1ccc(CNC(=O)N2CCN(CC2)c2ncnc3[nH]cc(C#N)c23)cc1 InChI=1S/C19H18FN7O/c20-15-3-1-13(2-4-15)10-23-19(28)27-7-5-26(6-8-27)18-16-14(9-21)11-22-17(16)24-12-25-18/h1-4,11-12H,5-8,10H2,(H,23,28)(H,22,24,25) RBALINMSAIGBPA-UHFFFAOYSA-N 368905 4-[6-(4-fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[(4- methoxyphenyl)methyl]piperazine-1- carboxamide::US10227357, Compound P-0157 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368905 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368905&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114521 402365704 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728950 Cc1ccccc1Cc1c[nH]c2ncnc(N3CCN(CC3)C(=O)NCc3ccc(F)cc3)c12 InChI=1S/C26H27FN6O/c1-18-4-2-3-5-20(18)14-21-16-28-24-23(21)25(31-17-30-24)32-10-12-33(13-11-32)26(34)29-15-19-6-8-22(27)9-7-19/h2-9,16-17H,10-15H2,1H3,(H,29,34)(H,28,30,31) KVQZFXHQOZHVOH-UHFFFAOYSA-N 368906 4-(5-cyano-7H-pyrrolo[2,3-d]pyrimidin-4-yl)- N-[(4-fluorophenyl)methyl]piperazine-1- carboxamide::US10227357, Compound P-0158 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368906 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368906&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115084 402365705 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728951 Cc1ccccc1C(=O)c1c[nH]c2ncnc(N3CCN(CC3)C(=O)NCc3ccc(F)cc3)c12 InChI=1S/C26H25FN6O2/c1-17-4-2-3-5-20(17)23(34)21-15-28-24-22(21)25(31-16-30-24)32-10-12-33(13-11-32)26(35)29-14-18-6-8-19(27)9-7-18/h2-9,15-16H,10-14H2,1H3,(H,29,35)(H,28,30,31) AIGMUPNKMIWGTN-UHFFFAOYSA-N 368907 N-[(4-fluorophenyl)methyl]-4-[5-(o- tolylmethyl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]piperazine-1-carboxamide::US10227357, Compound P-0159 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368907 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368907&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114725 402365706 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728952 Cc1ccccc1C(=O)c1c[nH]c2ncnc(N3CCN(CC3)C(=O)NCc3ccc(F)cc3)c12 InChI=1S/C26H25FN6O2/c1-17-4-2-3-5-20(17)23(34)21-15-28-24-22(21)25(31-16-30-24)32-10-12-33(13-11-32)26(35)29-14-18-6-8-19(27)9-7-18/h2-9,15-16H,10-14H2,1H3,(H,29,35)(H,28,30,31) AIGMUPNKMIWGTN-UHFFFAOYSA-N 368907 N-[(4-fluorophenyl)methyl]-4-[5-(o- tolylmethyl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]piperazine-1-carboxamide::US10227357, Compound P-0159 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368907 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368907&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114725 402365706 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728953 Fc1ccc(cc1)-c1cc2c(ncnc2[nH]1)N1CCN(CC1)C(=O)NCCc1ccc(Cl)cc1 InChI=1S/C25H24ClFN6O/c26-19-5-1-17(2-6-19)9-10-28-25(34)33-13-11-32(12-14-33)24-21-15-22(31-23(21)29-16-30-24)18-3-7-20(27)8-4-18/h1-8,15-16H,9-14H2,(H,28,34)(H,29,30,31) SSUASGOKNLCPCK-UHFFFAOYSA-N 368908 N-[(4-fluorophenyl)methyl]-4-[5-(2- methylbenzoyl)-7H-pyrrolo[2,3-d]pyrimidin- 4-yl]piperazine-1-carboxamide::US10227357, Compound P-0160 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368908 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368908&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115464 402365707 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728954 Fc1ccc(cc1)-c1cc2c(ncnc2[nH]1)N1CCN(CC1)C(=O)NCCc1ccccc1 InChI=1S/C25H25FN6O/c26-20-8-6-19(7-9-20)22-16-21-23(30-22)28-17-29-24(21)31-12-14-32(15-13-31)25(33)27-11-10-18-4-2-1-3-5-18/h1-9,16-17H,10-15H2,(H,27,33)(H,28,29,30) GVKIHMRAHALUMA-UHFFFAOYSA-N 368909 N-[2-(4-chlorophenyl)ethyl]-4-[6-(4- fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]piperazine-1-carboxamide::US10227357, Compound P-0161 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368909 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368909&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114693 402365708 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728955 Fc1cccc(CNC(=O)N2CCN(CC2)c2ncnc3[nH]ccc23)c1 InChI=1S/C18H19FN6O/c19-14-3-1-2-13(10-14)11-21-18(26)25-8-6-24(7-9-25)17-15-4-5-20-16(15)22-12-23-17/h1-5,10,12H,6-9,11H2,(H,21,26)(H,20,22,23) ANBNQFXQVPGQQU-UHFFFAOYSA-N 368910 4-[6-(4-fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-phenethyl-piperazine-1- carboxamide::US10227357, Compound P-0162 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368910 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368910&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114302 402365709 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728956 Fc1ccc(CCNC(=O)N2CCN(CC2)c2ncnc3[nH]ccc23)cc1 InChI=1S/C19H21FN6O/c20-15-3-1-14(2-4-15)5-7-22-19(27)26-11-9-25(10-12-26)18-16-6-8-21-17(16)23-13-24-18/h1-4,6,8,13H,5,7,9-12H2,(H,22,27)(H,21,23,24) RHJAXLQSBYGNDR-UHFFFAOYSA-N 368911 N-[(3-fluorophenyl)methyl]-4-(7H- pyrrolo[2,3-d]pyrimidin-4-yl)piperazine-1- carboxamide::US10227357, Compound P-0163 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368911 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368911&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115238 402365710 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728957 Fc1ccc(NC(=O)N2CCN(CC2)c2ncnc3[nH]ccc23)cc1Cl InChI=1S/C17H16ClFN6O/c18-13-9-11(1-2-14(13)19)23-17(26)25-7-5-24(6-8-25)16-12-3-4-20-15(12)21-10-22-16/h1-4,9-10H,5-8H2,(H,23,26)(H,20,21,22) ZRHAQHNXNLRXOW-UHFFFAOYSA-N 368912 N-[2-(4-fluorophenyl)ethyl]-4-(7H- pyrrolo[2,3-d]pyrimidin-4-yl)piperazine-1- carboxamide::US10227357, Compound P-0164 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368912 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368912&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114884 402365711 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728958 FC(F)(F)c1ccc(NC(=O)N2CCN(CC2)c2ncnc3[nH]ccc23)cc1 InChI=1S/C18H17F3N6O/c19-18(20,21)12-1-3-13(4-2-12)25-17(28)27-9-7-26(8-10-27)16-14-5-6-22-15(14)23-11-24-16/h1-6,11H,7-10H2,(H,25,28)(H,22,23,24) SOXDVKZPNXPXGA-UHFFFAOYSA-N 368913 N-(3-chloro-4-fluoro-phenyl)-4-(7H- pyrrolo[2,3-d]pyrimidin-4-yl)piperazine-1- carboxamide::US10227357, Compound P-0165 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368913 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368913&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90003402 402365712 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728959 FC(F)(F)c1ccc(NC(=O)N2CCN(CC2)c2ncnc3[nH]ccc23)cc1 InChI=1S/C18H17F3N6O/c19-18(20,21)12-1-3-13(4-2-12)25-17(28)27-9-7-26(8-10-27)16-14-5-6-22-15(14)23-11-24-16/h1-6,11H,7-10H2,(H,25,28)(H,22,23,24) SOXDVKZPNXPXGA-UHFFFAOYSA-N 368913 N-(3-chloro-4-fluoro-phenyl)-4-(7H- pyrrolo[2,3-d]pyrimidin-4-yl)piperazine-1- carboxamide::US10227357, Compound P-0165 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368913 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368913&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90003402 402365712 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728960 FC(F)(F)c1cccc(NC(=O)N2CCN(CC2)c2ncnc3[nH]ccc23)c1 InChI=1S/C18H17F3N6O/c19-18(20,21)12-2-1-3-13(10-12)25-17(28)27-8-6-26(7-9-27)16-14-4-5-22-15(14)23-11-24-16/h1-5,10-11H,6-9H2,(H,25,28)(H,22,23,24) IRTHNPWRNFRYGW-UHFFFAOYSA-N 368914 4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-N-[4- (trifluoromethyl)phenyl]piperazine-1- carboxamide::US10227357, Compound P-0166 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368914 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368914&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90004125 402365713 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728961 FC(F)(F)c1cccc(NC(=O)N2CCN(CC2)c2ncnc3[nH]ccc23)c1 InChI=1S/C18H17F3N6O/c19-18(20,21)12-2-1-3-13(10-12)25-17(28)27-8-6-26(7-9-27)16-14-4-5-22-15(14)23-11-24-16/h1-5,10-11H,6-9H2,(H,25,28)(H,22,23,24) IRTHNPWRNFRYGW-UHFFFAOYSA-N 368914 4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-N-[4- (trifluoromethyl)phenyl]piperazine-1- carboxamide::US10227357, Compound P-0166 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368914 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368914&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90004125 402365713 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728962 Clc1cccc(NC(=O)N2CCN(CC2)c2ncnc3[nH]ccc23)c1 InChI=1S/C17H17ClN6O/c18-12-2-1-3-13(10-12)22-17(25)24-8-6-23(7-9-24)16-14-4-5-19-15(14)20-11-21-16/h1-5,10-11H,6-9H2,(H,22,25)(H,19,20,21) KLKKFVMTYCCBBA-UHFFFAOYSA-N 368915 4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-N-[3- (trifluoromethyl)phenyl]piperazine-1- carboxamide::US10227357, Compound P-0167 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368915 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368915&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90001821 402365714 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728963 Clc1cccc(NC(=O)N2CCN(CC2)c2ncnc3[nH]ccc23)c1 InChI=1S/C17H17ClN6O/c18-12-2-1-3-13(10-12)22-17(25)24-8-6-23(7-9-24)16-14-4-5-19-15(14)20-11-21-16/h1-5,10-11H,6-9H2,(H,22,25)(H,19,20,21) KLKKFVMTYCCBBA-UHFFFAOYSA-N 368915 4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-N-[3- (trifluoromethyl)phenyl]piperazine-1- carboxamide::US10227357, Compound P-0167 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368915 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368915&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90001821 402365714 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728964 COc1ccc(CCNC(=O)N2CCN(CC2)c2ncnc3[nH]ccc23)cc1 InChI=1S/C20H24N6O2/c1-28-16-4-2-15(3-5-16)6-8-22-20(27)26-12-10-25(11-13-26)19-17-7-9-21-18(17)23-14-24-19/h2-5,7,9,14H,6,8,10-13H2,1H3,(H,22,27)(H,21,23,24) XETCIANUSSYHEC-UHFFFAOYSA-N 368916 N-(3-chlorophenyl)-4-(7H-pyrrolo[2,3- d]pyrimidin-4-yl)piperazine-1-carboxamide::US10227357, Compound P-0168 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368916 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368916&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114195 402365715 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728965 COc1ccc(CCNC(=O)N2CCN(CC2)c2ncnc3[nH]ccc23)cc1 InChI=1S/C20H24N6O2/c1-28-16-4-2-15(3-5-16)6-8-22-20(27)26-12-10-25(11-13-26)19-17-7-9-21-18(17)23-14-24-19/h2-5,7,9,14H,6,8,10-13H2,1H3,(H,22,27)(H,21,23,24) XETCIANUSSYHEC-UHFFFAOYSA-N 368916 N-(3-chlorophenyl)-4-(7H-pyrrolo[2,3- d]pyrimidin-4-yl)piperazine-1-carboxamide::US10227357, Compound P-0168 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368916 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368916&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114195 402365715 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728966 Clc1ccc(CNC(=O)N2CCN(CC2)c2ncnc3[nH]ccc23)cc1 InChI=1S/C18H19ClN6O/c19-14-3-1-13(2-4-14)11-21-18(26)25-9-7-24(8-10-25)17-15-5-6-20-16(15)22-12-23-17/h1-6,12H,7-11H2,(H,21,26)(H,20,22,23) UTXWEEORYBOWTB-UHFFFAOYSA-N 368917 N-[2-(4-methoxyphenyl)ethyl]-4-(7H- pyrrolo[2,3-d]pyrimidin-4-yl)piperazine-1- carboxamide::US10227357, Compound P-0169 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368917 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368917&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90001125 402365716 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728967 Clc1ccc(CNC(=O)N2CCN(CC2)c2ncnc3[nH]ccc23)cc1 InChI=1S/C18H19ClN6O/c19-14-3-1-13(2-4-14)11-21-18(26)25-9-7-24(8-10-25)17-15-5-6-20-16(15)22-12-23-17/h1-6,12H,7-11H2,(H,21,26)(H,20,22,23) UTXWEEORYBOWTB-UHFFFAOYSA-N 368917 N-[2-(4-methoxyphenyl)ethyl]-4-(7H- pyrrolo[2,3-d]pyrimidin-4-yl)piperazine-1- carboxamide::US10227357, Compound P-0169 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368917 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368917&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90001125 402365716 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728968 Clc1ccc(NC(=O)N2CCN(CC2)c2ncnc3[nH]ccc23)cc1 InChI=1S/C17H17ClN6O/c18-12-1-3-13(4-2-12)22-17(25)24-9-7-23(8-10-24)16-14-5-6-19-15(14)20-11-21-16/h1-6,11H,7-10H2,(H,22,25)(H,19,20,21) AWRYMGHMAYTTGU-UHFFFAOYSA-N 368918 N-[(4-chlorophenyl)methyl]-4-(7H- pyrrolo[2,3-d]pyrimidin-4-yl)piperazine-1- carboxamide::US10227357, Compound P-0170 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368918 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368918&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90001362 402365717 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728969 Clc1ccc(NC(=O)N2CCN(CC2)c2ncnc3[nH]ccc23)cc1 InChI=1S/C17H17ClN6O/c18-12-1-3-13(4-2-12)22-17(25)24-9-7-23(8-10-24)16-14-5-6-19-15(14)20-11-21-16/h1-6,11H,7-10H2,(H,22,25)(H,19,20,21) AWRYMGHMAYTTGU-UHFFFAOYSA-N 368918 N-[(4-chlorophenyl)methyl]-4-(7H- pyrrolo[2,3-d]pyrimidin-4-yl)piperazine-1- carboxamide::US10227357, Compound P-0170 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368918 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368918&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90001362 402365717 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728970 O=C(Nc1ccc(cc1)C#N)N1CCN(CC1)c1ncnc2[nH]ccc12 InChI=1S/C18H17N7O/c19-11-13-1-3-14(4-2-13)23-18(26)25-9-7-24(8-10-25)17-15-5-6-20-16(15)21-12-22-17/h1-6,12H,7-10H2,(H,23,26)(H,20,21,22) CPLGKQJBCGHMPY-UHFFFAOYSA-N 368919 N-(4-chlorophenyl)-4-(7H-pyrrolo[2,3- d]pyrimidin-4-yl)piperazine-1-carboxamide::US10227357, Compound P-0171 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368919 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368919&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114660 402365718 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728971 O=C(Nc1ccc(cc1)C#N)N1CCN(CC1)c1ncnc2[nH]ccc12 InChI=1S/C18H17N7O/c19-11-13-1-3-14(4-2-13)23-18(26)25-9-7-24(8-10-25)17-15-5-6-20-16(15)21-12-22-17/h1-6,12H,7-10H2,(H,23,26)(H,20,21,22) CPLGKQJBCGHMPY-UHFFFAOYSA-N 368919 N-(4-chlorophenyl)-4-(7H-pyrrolo[2,3- d]pyrimidin-4-yl)piperazine-1-carboxamide::US10227357, Compound P-0171 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368919 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368919&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114660 402365718 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728972 O=C(NC(=O)c1ccccc1)N1CCN(CC1)c1ncnc2[nH]ccc12 InChI=1S/C18H18N6O2/c25-17(13-4-2-1-3-5-13)22-18(26)24-10-8-23(9-11-24)16-14-6-7-19-15(14)20-12-21-16/h1-7,12H,8-11H2,(H,19,20,21)(H,22,25,26) NJRNXMMBYIAMBR-UHFFFAOYSA-N 368920 N-(3,4-dimethoxyphenyl)-4-(7H-pyrrolo[2,3- d]pyrimidin-4-yl)piperazine-1-carboxamide::US10227357, Compound P-0173 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368920 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368920&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114944 402365719 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728973 Fc1ccc(NC(=O)N2CCN(CC2)c2ncnc3[nH]ccc23)cc1F InChI=1S/C17H16F2N6O/c18-13-2-1-11(9-14(13)19)23-17(26)25-7-5-24(6-8-25)16-12-3-4-20-15(12)21-10-22-16/h1-4,9-10H,5-8H2,(H,23,26)(H,20,21,22) MFROKXVUCNDGMQ-UHFFFAOYSA-N 368921 N-benzoyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4- yl)piperazine-1-carboxamide::US10227357, Compound P-0174 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368921 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368921&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114850 402365720 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728974 CCc1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ncnc2[nH]ccc12 InChI=1S/C18H21N5O2S/c1-2-14-3-5-15(6-4-14)26(24,25)23-11-9-22(10-12-23)18-16-7-8-19-17(16)20-13-21-18/h3-8,13H,2,9-12H2,1H3,(H,19,20,21) GUBSVJXQGFGQMW-UHFFFAOYSA-N 368922 N-(3,4-difluorophenyl)-4-(7H-pyrrolo[2,3- d]pyrimidin-4-yl)piperazine-1-carboxamide::US10227357, Compound P-0175 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368922 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368922&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114505 402365721 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728975 C[C@H](NC(=O)N1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1)c1ccc(Cl)cc1 368923 N-cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin- 4-yl)piperazine-1-carboxamide::US10227357, Compound P-0177 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368923 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368923&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 73389456 402365722 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728976 C[C@H](NC(=O)N1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1)c1ccc(Cl)cc1 368923 N-cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin- 4-yl)piperazine-1-carboxamide::US10227357, Compound P-0177 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368923 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368923&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 73389456 402365722 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728977 Fc1ccc(CNC(=O)N2CCN(CC2)c2ncnc3[nH]cc(C4CC4)c23)cc1 InChI=1S/C21H23FN6O/c22-16-5-1-14(2-6-16)11-24-21(29)28-9-7-27(8-10-28)20-18-17(15-3-4-15)12-23-19(18)25-13-26-20/h1-2,5-6,12-13,15H,3-4,7-11H2,(H,24,29)(H,23,25,26) YLQXNTINTNTCHF-UHFFFAOYSA-N 368924 N-[(1S)-1-(4-chlorophenyl)ethyl]-4-[6-(4- fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]piperazine-1-carboxamide::US10227357, Compound P-0178 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368924 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368924&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114860 402365723 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728978 FC(F)(F)c1ccc(CNC(=O)N2CCN(CC2)c2ncnc3[nH]c(cc23)-c2ccc(Cl)cc2)cn1 InChI=1S/C24H21ClF3N7O/c25-17-4-2-16(3-5-17)19-11-18-21(33-19)31-14-32-22(18)34-7-9-35(10-8-34)23(36)30-13-15-1-6-20(29-12-15)24(26,27)28/h1-6,11-12,14H,7-10,13H2,(H,30,36)(H,31,32,33) MPBULGNIWQLCEN-UHFFFAOYSA-N 368925 4-(5-cyclopropyl-7H-pyrrolo[2,3-d]pyrimidin- 4-yl)-N-[(4-fluorophenyl)methyl]piperazine-1- carboxamide::US10227357, Compound P-0179 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368925 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368925&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114871 402365724 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728979 CCOc1ccc(NC(=O)N2CCN(CC2)c2ncnc3[nH]c(C)cc23)cc1 InChI=1S/C20H24N6O2/c1-3-28-16-6-4-15(5-7-16)24-20(27)26-10-8-25(9-11-26)19-17-12-14(2)23-18(17)21-13-22-19/h4-7,12-13H,3,8-11H2,1-2H3,(H,24,27)(H,21,22,23) GUPYLIQRXLVSEW-UHFFFAOYSA-N 368926 4-[6-(4-chlorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[[6-(trifluoromethyl)-3- pyridyl]methyl]piperazine-1-carboxamide::US10227357, Compound P-0180 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368926 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368926&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115023 402365725 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728980 Fc1ccc(CNC(=O)N2CCN(CC2)c2ncnc3[nH]ccc23)cc1 InChI=1S/C18H19FN6O/c19-14-3-1-13(2-4-14)11-21-18(26)25-9-7-24(8-10-25)17-15-5-6-20-16(15)22-12-23-17/h1-6,12H,7-11H2,(H,21,26)(H,20,22,23) JSJOSEKUPYTTAQ-UHFFFAOYSA-N 368927 N-(4-ethoxyphenyl)-4-(6-methyl-7H- pyrrolo[2,3-d]pyrimidin-4-yl)piperazine-1- carboxamide::US10227357, Compound P-0181 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368927 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368927&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114401 402365726 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728981 Fc1ccc(CNC(=O)N2CCN(CC2)c2ncnc3[nH]ccc23)cc1 InChI=1S/C18H19FN6O/c19-14-3-1-13(2-4-14)11-21-18(26)25-9-7-24(8-10-25)17-15-5-6-20-16(15)22-12-23-17/h1-6,12H,7-11H2,(H,21,26)(H,20,22,23) JSJOSEKUPYTTAQ-UHFFFAOYSA-N 368927 N-(4-ethoxyphenyl)-4-(6-methyl-7H- pyrrolo[2,3-d]pyrimidin-4-yl)piperazine-1- carboxamide::US10227357, Compound P-0181 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368927 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368927&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114401 402365726 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728982 Fc1ccc(NC(=O)N2CCN(CC2)c2ncnc3[nH]ccc23)cc1 InChI=1S/C17H17FN6O/c18-12-1-3-13(4-2-12)22-17(25)24-9-7-23(8-10-24)16-14-5-6-19-15(14)20-11-21-16/h1-6,11H,7-10H2,(H,22,25)(H,19,20,21) ARTLSCHOSBEPTQ-UHFFFAOYSA-N 368928 N-[(4-fluorophenyl)methyl]-4-(7H- pyrrolo[2,3-d]pyrimidin-4-yl)piperazine-1- carboxamide::US10227357, Compound P-0182 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368928 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368928&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114524 402365727 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728983 Fc1ccc(NC(=O)N2CCN(CC2)c2ncnc3[nH]ccc23)cc1 InChI=1S/C17H17FN6O/c18-12-1-3-13(4-2-12)22-17(25)24-9-7-23(8-10-24)16-14-5-6-19-15(14)20-11-21-16/h1-6,11H,7-10H2,(H,22,25)(H,19,20,21) ARTLSCHOSBEPTQ-UHFFFAOYSA-N 368928 N-[(4-fluorophenyl)methyl]-4-(7H- pyrrolo[2,3-d]pyrimidin-4-yl)piperazine-1- carboxamide::US10227357, Compound P-0182 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368928 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368928&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114524 402365727 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728984 FC(F)(F)Oc1ccc(NC(=O)N2CCN(CC2)c2ncnc3[nH]ccc23)cc1 InChI=1S/C18H17F3N6O2/c19-18(20,21)29-13-3-1-12(2-4-13)25-17(28)27-9-7-26(8-10-27)16-14-5-6-22-15(14)23-11-24-16/h1-6,11H,7-10H2,(H,25,28)(H,22,23,24) NFAPZFJRSYVIHA-UHFFFAOYSA-N 368929 N-(4-fluorophenyl)-4-(7H-pyrrolo[2,3- d]pyrimidin-4-yl)piperazine-1-carboxamide::US10227357, Compound P-0183 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368929 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368929&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114779 402365728 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728985 FC(F)(F)Oc1ccc(NC(=O)N2CCN(CC2)c2ncnc3[nH]ccc23)cc1 InChI=1S/C18H17F3N6O2/c19-18(20,21)29-13-3-1-12(2-4-13)25-17(28)27-9-7-26(8-10-27)16-14-5-6-22-15(14)23-11-24-16/h1-6,11H,7-10H2,(H,25,28)(H,22,23,24) NFAPZFJRSYVIHA-UHFFFAOYSA-N 368929 N-(4-fluorophenyl)-4-(7H-pyrrolo[2,3- d]pyrimidin-4-yl)piperazine-1-carboxamide::US10227357, Compound P-0183 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368929 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368929&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114779 402365728 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728986 C[C@H](NC(=O)N1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(Cl)cc1)c1ccc(Cl)cc1 368930 US10227357, Compound P-0187::tert-butyl 4-[5-(2-methylbenzoyl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]piperazine-1- carboxylate Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368930 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368930&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114349 402365729 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728987 C[C@H](NC(=O)N1CCN(CC1)c1ncnc2[nH]c(cc12)-c1cccnc1)c1ccc(Cl)cc1 368931 N-[(1S)-1-(4-chlorophenyl)ethyl]-4-[6-(4- chlorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]piperazine-1-carboxamide::US10227357, Compound P-0188 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368931 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368931&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114551 402365730 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728988 C[C@H](NC(=O)N1CCN(CC1)c1ncnc2[nH]c(cc12)-c1cccnc1)c1ccc(Cl)cc1 368931 N-[(1S)-1-(4-chlorophenyl)ethyl]-4-[6-(4- chlorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]piperazine-1-carboxamide::US10227357, Compound P-0188 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368931 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368931&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114551 402365730 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728989 FC(F)(F)Oc1ccc(NC(=O)N2CCN(CC2)c2ncnc3[nH]c(I)cc23)cc1 InChI=1S/C18H16F3IN6O2/c19-18(20,21)30-12-3-1-11(2-4-12)25-17(29)28-7-5-27(6-8-28)16-13-9-14(22)26-15(13)23-10-24-16/h1-4,9-10H,5-8H2,(H,25,29)(H,23,24,26) AVLRBSYPXSRGBC-UHFFFAOYSA-N 368932 5-methoxy-2-[4-(7H-pyrrolo[2,3-d]pyrimidin- 4-yl)piperazin-1-yl]sulfonyl-aniline::US10227357, Compound P-0190 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368932 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368932&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114548 402365731 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728990 CCCC(=O)N1CCN(CC1)c1ncnc2[nH]ccc12 InChI=1S/C14H19N5O/c1-2-3-12(20)18-6-8-19(9-7-18)14-11-4-5-15-13(11)16-10-17-14/h4-5,10H,2-3,6-9H2,1H3,(H,15,16,17) YWWZCRTXPMJUHS-UHFFFAOYSA-N 368933 4-[4-[(4- fluorophenyl)methylcarbamoyl]piperazin-1- yl]-N-phenyl-7H-pyrrolo[2,3-d]pyrimidine-6- carboxamide::US10227357, Compound P-0193 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368933 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368933&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114228 402365732 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728991 O=C(C1CCCCC1)N1CCN(CC1)c1ncnc2[nH]ccc12 InChI=1S/C17H23N5O/c23-17(13-4-2-1-3-5-13)22-10-8-21(9-11-22)16-14-6-7-18-15(14)19-12-20-16/h6-7,12-13H,1-5,8-11H2,(H,18,19,20) XUJWXPUCPSFPQO-UHFFFAOYSA-N 368934 1-[4-(7H-pyrrolo[2,3-d]pyrimidin-4- yl)piperazin-1-yl]butan-1-one::US10227357, Compound P-0194 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368934 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368934&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114690 402365733 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728992 O=C(C1CCCC1)N1CCN(CC1)c1ncnc2[nH]ccc12 InChI=1S/C16H21N5O/c22-16(12-3-1-2-4-12)21-9-7-20(8-10-21)15-13-5-6-17-14(13)18-11-19-15/h5-6,11-12H,1-4,7-10H2,(H,17,18,19) XYSNOEJLAFSMBR-UHFFFAOYSA-N 368935 US10227357, Compound P-0195::cyclohexyl-[4-(7H-pyrrolo[2,3-d]pyrimidin-4- yl)piperazin-1-yl]methanone Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368935 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368935&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114485 402365734 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728993 CCc1ccc(cc1)C(=O)N1CCN(CC1)c1ncnc2[nH]ccc12 InChI=1S/C19H21N5O/c1-2-14-3-5-15(6-4-14)19(25)24-11-9-23(10-12-24)18-16-7-8-20-17(16)21-13-22-18/h3-8,13H,2,9-12H2,1H3,(H,20,21,22) MCQZRGFBWDNDAO-UHFFFAOYSA-N 368936 US10227357, Compound P-0196::cyclopentyl-[4-(7H-pyrrolo[2,3-d]pyrimidin-4- yl)piperazin-1-yl]methanone Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368936 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368936&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114469 402365735 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728994 O=C(N1CCN(CC1)c1ncnc2[nH]ccc12)c1ccccc1 InChI=1S/C17H17N5O/c23-17(13-4-2-1-3-5-13)22-10-8-21(9-11-22)16-14-6-7-18-15(14)19-12-20-16/h1-7,12H,8-11H2,(H,18,19,20) VBSVDGDYOPVBFX-UHFFFAOYSA-N 368937 (4-ethylphenyl)-[4-(7H-pyrrolo[2,3- d]pyrimidin-4-yl)piperazin-1-yl]methanone::US10227357, Compound P-0197 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368937 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368937&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114085 402365736 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728995 CCCS(=O)(=O)N1CCN(CC1)c1ncnc2[nH]ccc12 InChI=1S/C13H19N5O2S/c1-2-9-21(19,20)18-7-5-17(6-8-18)13-11-3-4-14-12(11)15-10-16-13/h3-4,10H,2,5-9H2,1H3,(H,14,15,16) VUNPNXYGQRMZCE-UHFFFAOYSA-N 368938 US10227357, Compound P-0198::phenyl-[4-(7H-pyrrolo[2,3-d]pyrimidin-4- yl)piperazin-1-yl]methanone Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368938 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368938&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114216 402365737 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728996 O=S(=O)(N1CCN(CC1)c1ncnc2[nH]ccc12)c1ccccc1 InChI=1S/C16H17N5O2S/c22-24(23,13-4-2-1-3-5-13)21-10-8-20(9-11-21)16-14-6-7-17-15(14)18-12-19-16/h1-7,12H,8-11H2,(H,17,18,19) GNTLDVDLAQITMY-UHFFFAOYSA-N 368939 4-(4-propylsulfonylpiperazin-1-yl)-7H- pyrrolo[2,3-d]pyrimidine::US10227357, Compound P-0199 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368939 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368939&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114684 402365738 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728997 CCOc1ccc(NC(=O)N2CCN(CC2)c2ncnc3[nH]ccc23)cc1 InChI=1S/C19H22N6O2/c1-2-27-15-5-3-14(4-6-15)23-19(26)25-11-9-24(10-12-25)18-16-7-8-20-17(16)21-13-22-18/h3-8,13H,2,9-12H2,1H3,(H,23,26)(H,20,21,22) SBWCFGLRLRWRQK-UHFFFAOYSA-N 368940 4-[4-(benzenesulfonyl)piperazin-1-yl]-7H- pyrrolo[2,3-d]pyrimidine::US10227357, Compound P-0200 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368940 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368940&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114820 402365739 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728998 CCc1ccc(NC(=O)N2CCN(CC2)c2ncnc3[nH]ccc23)cc1 InChI=1S/C19H22N6O/c1-2-14-3-5-15(6-4-14)23-19(26)25-11-9-24(10-12-25)18-16-7-8-20-17(16)21-13-22-18/h3-8,13H,2,9-12H2,1H3,(H,23,26)(H,20,21,22) PETRBQZINIGDEL-UHFFFAOYSA-N 368941 N-(4-ethoxyphenyl)-4-(7H-pyrrolo[2,3- d]pyrimidin-4-yl)piperazine-1-carboxamide::US10227357, Compound P-0201 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368941 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368941&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115034 402365740 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 728999 CCCNC(=O)N1CCN(CC1)c1ncnc2[nH]ccc12 InChI=1S/C14H20N6O/c1-2-4-16-14(21)20-8-6-19(7-9-20)13-11-3-5-15-12(11)17-10-18-13/h3,5,10H,2,4,6-9H2,1H3,(H,16,21)(H,15,17,18) XAOFJYUSHIMNNE-UHFFFAOYSA-N 368942 N-(4-ethylphenyl)-4-(7H-pyrrolo[2,3- d]pyrimidin-4-yl)piperazine-1-carboxamide::US10227357, Compound P-0202 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368942 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368942&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115152 402365741 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729000 O=C(NC1CCCCC1)N1CCN(CC1)c1ncnc2[nH]ccc12 InChI=1S/C17H24N6O/c24-17(21-13-4-2-1-3-5-13)23-10-8-22(9-11-23)16-14-6-7-18-15(14)19-12-20-16/h6-7,12-13H,1-5,8-11H2,(H,21,24)(H,18,19,20) AEVASQGGCPVQKN-UHFFFAOYSA-N 368943 N-propyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4- yl)piperazine-1-carboxamide::US10227357, Compound P-0203 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368943 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368943&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114775 402365742 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729001 O=C(Nc1ccccc1)N1CCN(CC1)c1ncnc2[nH]ccc12 InChI=1S/C17H18N6O/c24-17(21-13-4-2-1-3-5-13)23-10-8-22(9-11-23)16-14-6-7-18-15(14)19-12-20-16/h1-7,12H,8-11H2,(H,21,24)(H,18,19,20) SDOXUQMIKGPROR-UHFFFAOYSA-N 368944 N-cyclohexyl-4-(7H-pyrrolo[2,3-d]pyrimidin- 4-yl)piperazine-1-carboxamide::US10227357, Compound P-0204 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368944 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368944&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114653 402365743 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729002 Cc1ccccc1C(=O)c1c[nH]c2ncnc(N3CCN(CC3)c3cc(NC4CC4)ncn3)c12 InChI=1S/C25H26N8O/c1-16-4-2-3-5-18(16)23(34)19-13-26-24-22(19)25(30-15-29-24)33-10-8-32(9-11-33)21-12-20(27-14-28-21)31-17-6-7-17/h2-5,12-15,17H,6-11H2,1H3,(H,26,29,30)(H,27,28,31) KDFSJJGUELGYNQ-UHFFFAOYSA-N 368945 N-phenyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4- yl)piperazine-1-carboxamide::US10227357, Compound P-0205 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368945 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368945&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114723 402365744 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729003 Fc1ccc(CNC(=O)N2CCN(CC2)c2ncnc3[nH]c(cc23)C(=O)c2ccc(Cl)cc2)cc1 InChI=1S/C25H22ClFN6O2/c26-18-5-3-17(4-6-18)22(34)21-13-20-23(31-21)29-15-30-24(20)32-9-11-33(12-10-32)25(35)28-14-16-1-7-19(27)8-2-16/h1-8,13,15H,9-12,14H2,(H,28,35)(H,29,30,31) IYEGVYVOVXBZEM-UHFFFAOYSA-N 368946 US10227357, Compound P-0206::[4-[4-[6-(cyclopropylamino)pyrimidin-4- yl]piperazin-1-yl]-7H-pyrrolo[2,3-d]pyrimidin- 5-yl]-(o-tolyl)methanone Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368946 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368946&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115096 402365745 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729004 Fc1ccc(CNC(=O)N2CCN(CC2)c2ncnc3[nH]c(Cc4ccc(Cl)cc4)cc23)cc1 InChI=1S/C25H24ClFN6O/c26-19-5-1-17(2-6-19)13-21-14-22-23(31-21)29-16-30-24(22)32-9-11-33(12-10-32)25(34)28-15-18-3-7-20(27)8-4-18/h1-8,14,16H,9-13,15H2,(H,28,34)(H,29,30,31) RXAHSAUDIHXXNY-UHFFFAOYSA-N 368947 4-[6-(4-chlorobenzoyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[(4- fluorophenyl)methyl]piperazine-1- carboxamide::US10227357, Compound P-0207 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368947 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368947&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114420 402365746 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729005 Fc1ccc(CNC(=O)N2CCN(CC2)c2ncnc3[nH]c(CC4CC4)cc23)cc1 InChI=1S/C22H25FN6O/c23-17-5-3-16(4-6-17)13-24-22(30)29-9-7-28(8-10-29)21-19-12-18(11-15-1-2-15)27-20(19)25-14-26-21/h3-6,12,14-15H,1-2,7-11,13H2,(H,24,30)(H,25,26,27) QIVDDWGFIXKTCK-UHFFFAOYSA-N 368948 4-[6-(cyclopropanecarbonyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[(4- fluorophenyl)methyl]piperazine-1- carboxamide::US10227357, Compound P-0209 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368948 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368948&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114276 402365747 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729006 CC(C)(C)OC(=O)N1CCN(CC1)c1ncnc2[nH]c(cc12)C(=O)Nc1ccccc1 InChI=1S/C22H26N6O3/c1-22(2,3)31-21(30)28-11-9-27(10-12-28)19-16-13-17(26-18(16)23-14-24-19)20(29)25-15-7-5-4-6-8-15/h4-8,13-14H,9-12H2,1-3H3,(H,25,29)(H,23,24,26) RFQPRKZUODXQFR-UHFFFAOYSA-N 368949 4-[6-(cyclopropylmethyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[(4- fluorophenyl)methyl]piperazine-1- carboxamide::US10227357, Compound P-0210 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368949 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368949&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90001602 402365748 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729007 Clc1ccc(CNC(=O)N2CCN(CC2)c2ncnc3[nH]c(cc23)-c2ccc(Cl)cc2)cc1 InChI=1S/C24H22Cl2N6O/c25-18-5-1-16(2-6-18)14-27-24(33)32-11-9-31(10-12-32)23-20-13-21(30-22(20)28-15-29-23)17-3-7-19(26)8-4-17/h1-8,13,15H,9-12,14H2,(H,27,33)(H,28,29,30) KYFWPTAERBTKQL-UHFFFAOYSA-N 368950 US10227357, Compound P-0211::tert-butyl 4-[6-(phenylcarbamoyl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]piperazine-1- carboxylate Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368950 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368950&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90001962 402365749 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729008 Fc1ccc(CNC(=O)N2CCN(CC2)c2ncnc3[nH]c(cc23)-c2ccc(Cl)cc2)cc1 InChI=1S/C24H22ClFN6O/c25-18-5-3-17(4-6-18)21-13-20-22(30-21)28-15-29-23(20)31-9-11-32(12-10-31)24(33)27-14-16-1-7-19(26)8-2-16/h1-8,13,15H,9-12,14H2,(H,27,33)(H,28,29,30) AGJUSGYELQFTPT-UHFFFAOYSA-N 368951 N-[(4-chlorophenyl)methyl]-4-[6-(4- chlorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]piperazine-1-carboxamide::US10227357, Compound P-0212 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368951 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368951&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114231 402365750 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729009 Fc1ccc(CNC(=O)N2CCN(CC2)c2ncnc3[nH]c(cc23)-c2ccc(Cl)cc2)cc1 InChI=1S/C24H22ClFN6O/c25-18-5-3-17(4-6-18)21-13-20-22(30-21)28-15-29-23(20)31-9-11-32(12-10-31)24(33)27-14-16-1-7-19(26)8-2-16/h1-8,13,15H,9-12,14H2,(H,27,33)(H,28,29,30) AGJUSGYELQFTPT-UHFFFAOYSA-N 368951 N-[(4-chlorophenyl)methyl]-4-[6-(4- chlorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]piperazine-1-carboxamide::US10227357, Compound P-0212 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368951 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368951&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114231 402365750 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729010 CCOc1ccc(NC(=O)N2CCN(CC2)c2ncnc3[nH]c(cc23)-c2ccc(Cl)cc2)cc1 InChI=1S/C25H25ClN6O2/c1-2-34-20-9-7-19(8-10-20)29-25(33)32-13-11-31(12-14-32)24-21-15-22(30-23(21)27-16-28-24)17-3-5-18(26)6-4-17/h3-10,15-16H,2,11-14H2,1H3,(H,29,33)(H,27,28,30) FNSOXNDJIFYYEQ-UHFFFAOYSA-N 368952 4-[6-(4-chlorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[(4- fluorophenyl)methyl]piperazine-1- carboxamide::US10227357, Compound P-0213 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368952 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368952&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115275 402365751 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729011 CCOc1ccc(NC(=O)N2CCN(CC2)c2ncnc3[nH]c(cc23)-c2ccc(Cl)cc2)cc1 InChI=1S/C25H25ClN6O2/c1-2-34-20-9-7-19(8-10-20)29-25(33)32-13-11-31(12-14-32)24-21-15-22(30-23(21)27-16-28-24)17-3-5-18(26)6-4-17/h3-10,15-16H,2,11-14H2,1H3,(H,29,33)(H,27,28,30) FNSOXNDJIFYYEQ-UHFFFAOYSA-N 368952 4-[6-(4-chlorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[(4- fluorophenyl)methyl]piperazine-1- carboxamide::US10227357, Compound P-0213 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368952 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368952&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115275 402365751 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729012 Clc1ccc(CNC(=O)N2CCN(CC2)c2ncnc3[nH]c(cc23)-c2ccccc2)cc1 InChI=1S/C24H23ClN6O/c25-19-8-6-17(7-9-19)15-26-24(32)31-12-10-30(11-13-31)23-20-14-21(18-4-2-1-3-5-18)29-22(20)27-16-28-23/h1-9,14,16H,10-13,15H2,(H,26,32)(H,27,28,29) KYCKFKUUWHRVIS-UHFFFAOYSA-N 368953 4-[6-(4-chlorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-(4- ethoxyphenyl)piperazine-1-carboxamide::US10227357, Compound P-0214 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368953 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368953&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114625 402365752 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729013 Clc1ccc(CNC(=O)N2CCN(CC2)c2ncnc3[nH]c(cc23)-c2ccccc2)cc1 InChI=1S/C24H23ClN6O/c25-19-8-6-17(7-9-19)15-26-24(32)31-12-10-30(11-13-31)23-20-14-21(18-4-2-1-3-5-18)29-22(20)27-16-28-23/h1-9,14,16H,10-13,15H2,(H,26,32)(H,27,28,29) KYCKFKUUWHRVIS-UHFFFAOYSA-N 368953 4-[6-(4-chlorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-(4- ethoxyphenyl)piperazine-1-carboxamide::US10227357, Compound P-0214 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368953 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368953&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114625 402365752 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729014 COc1cc(NC(=O)N2CCN(CC2)c2ncnc3[nH]cc(-c4ccccc4)c23)cc(OC)c1 InChI=1S/C25H26N6O3/c1-33-19-12-18(13-20(14-19)34-2)29-25(32)31-10-8-30(9-11-31)24-22-21(17-6-4-3-5-7-17)15-26-23(22)27-16-28-24/h3-7,12-16H,8-11H2,1-2H3,(H,29,32)(H,26,27,28) CNWKTMIEMOODJS-UHFFFAOYSA-N 368954 N-[(4-chlorophenyl)methyl]-4-(6-phenyl-7H- pyrrolo[2,3-d]pyrimidin-4-yl)piperazine-1- carboxamide::US10227357, Compound P-0215 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368954 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368954&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114357 402365753 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729015 COc1cc(NC(=O)N2CCN(CC2)c2ncnc3[nH]cc(-c4ccccc4)c23)cc(OC)c1 InChI=1S/C25H26N6O3/c1-33-19-12-18(13-20(14-19)34-2)29-25(32)31-10-8-30(9-11-31)24-22-21(17-6-4-3-5-7-17)15-26-23(22)27-16-28-24/h3-7,12-16H,8-11H2,1-2H3,(H,29,32)(H,26,27,28) CNWKTMIEMOODJS-UHFFFAOYSA-N 368954 N-[(4-chlorophenyl)methyl]-4-(6-phenyl-7H- pyrrolo[2,3-d]pyrimidin-4-yl)piperazine-1- carboxamide::US10227357, Compound P-0215 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368954 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368954&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114357 402365753 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729016 COc1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ncnc2[nH]ccc12 InChI=1S/C17H19N5O3S/c1-25-13-2-4-14(5-3-13)26(23,24)22-10-8-21(9-11-22)17-15-6-7-18-16(15)19-12-20-17/h2-7,12H,8-11H2,1H3,(H,18,19,20) GHNXABVLYFMFBJ-UHFFFAOYSA-N 368955 N-(3,5-dimethoxyphenyl)-4-(5-phenyl-7H- pyrrolo[2,3-d]pyrimidin-4-yl)piperazine-1- carboxamide::US10227357, Compound P-0216 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368955 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368955&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115198 402365754 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729017 CCCNS(=O)(=O)N1CCN(CC1)c1ncnc2[nH]c(cc12)-c1cccnc1 InChI=1S/C18H23N7O2S/c1-2-5-22-28(26,27)25-9-7-24(8-10-25)18-15-11-16(14-4-3-6-19-12-14)23-17(15)20-13-21-18/h3-4,6,11-13,22H,2,5,7-10H2,1H3,(H,20,21,23) FRBBJDYWVZEVOY-UHFFFAOYSA-N 368956 4-[4-(4-methoxyphenyl)sulfonylpiperazin-1- yl]-7H-pyrrolo[2,3-d]pyrimidine::US10227357, Compound P-0217 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368956 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368956&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90137126 402365755 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729018 CCCNS(=O)(=O)N1CCN(CC1)c1ncnc2[nH]c(cc12)-c1cccnc1 InChI=1S/C18H23N7O2S/c1-2-5-22-28(26,27)25-9-7-24(8-10-25)18-15-11-16(14-4-3-6-19-12-14)23-17(15)20-13-21-18/h3-4,6,11-13,22H,2,5,7-10H2,1H3,(H,20,21,23) FRBBJDYWVZEVOY-UHFFFAOYSA-N 368956 4-[4-(4-methoxyphenyl)sulfonylpiperazin-1- yl]-7H-pyrrolo[2,3-d]pyrimidine::US10227357, Compound P-0217 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368956 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368956&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90137126 402365755 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729019 CCCNC(=O)N1CCN(CC1)c1ncnc2[nH]c(cc12)-c1cccnc1 InChI=1S/C19H23N7O/c1-2-5-21-19(27)26-9-7-25(8-10-26)18-15-11-16(14-4-3-6-20-12-14)24-17(15)22-13-23-18/h3-4,6,11-13H,2,5,7-10H2,1H3,(H,21,27)(H,22,23,24) IHIMUFNYJGYMMZ-UHFFFAOYSA-N 368957 N-propyl-4-[6-(3-pyridyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]piperazine-1-carboxamide::US10227357, Compound P-0218 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368957 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368957&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115293 402365756 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729020 CCCNC(=O)N1CCN(CC1)c1ncnc2[nH]c(cc12)-c1cccnc1 InChI=1S/C19H23N7O/c1-2-5-21-19(27)26-9-7-25(8-10-26)18-15-11-16(14-4-3-6-20-12-14)24-17(15)22-13-23-18/h3-4,6,11-13H,2,5,7-10H2,1H3,(H,21,27)(H,22,23,24) IHIMUFNYJGYMMZ-UHFFFAOYSA-N 368957 N-propyl-4-[6-(3-pyridyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]piperazine-1-carboxamide::US10227357, Compound P-0218 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368957 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368957&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115293 402365756 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729021 Clc1ccccc1NC(=O)N1CCN(CC1)c1ncnc2[nH]c(cc12)-c1cccnc1 InChI=1S/C22H20ClN7O/c23-17-5-1-2-6-18(17)28-22(31)30-10-8-29(9-11-30)21-16-12-19(15-4-3-7-24-13-15)27-20(16)25-14-26-21/h1-7,12-14H,8-11H2,(H,28,31)(H,25,26,27) GMJVCQPSVVPFFP-UHFFFAOYSA-N 368958 N-(2-chlorophenyl)-4-[6-(3-pyridyl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]piperazine-1- carboxamide::US10227357, Compound P-0219 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368958 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368958&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115129 402365757 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729022 Clc1ccccc1NC(=O)N1CCN(CC1)c1ncnc2[nH]c(cc12)-c1cccnc1 InChI=1S/C22H20ClN7O/c23-17-5-1-2-6-18(17)28-22(31)30-10-8-29(9-11-30)21-16-12-19(15-4-3-7-24-13-15)27-20(16)25-14-26-21/h1-7,12-14H,8-11H2,(H,28,31)(H,25,26,27) GMJVCQPSVVPFFP-UHFFFAOYSA-N 368958 N-(2-chlorophenyl)-4-[6-(3-pyridyl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]piperazine-1- carboxamide::US10227357, Compound P-0219 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368958 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368958&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115129 402365757 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729023 CCOc1cccc(NC(=O)N2CCN(CC2)c2ncnc3[nH]c(cc23)-c2cccnc2)c1 InChI=1S/C24H25N7O2/c1-2-33-19-7-3-6-18(13-19)28-24(32)31-11-9-30(10-12-31)23-20-14-21(17-5-4-8-25-15-17)29-22(20)26-16-27-23/h3-8,13-16H,2,9-12H2,1H3,(H,28,32)(H,26,27,29) QCXXZHLEQSZCFR-UHFFFAOYSA-N 368959 N-(2-chlorophenyl)-4-[6-(3-pyridyl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]piperazine-1- carboxamide::US10227357, Compound P-0220 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368959 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368959&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114833 402365758 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729024 CCOc1cccc(NC(=O)N2CCN(CC2)c2ncnc3[nH]c(cc23)-c2cccnc2)c1 InChI=1S/C24H25N7O2/c1-2-33-19-7-3-6-18(13-19)28-24(32)31-11-9-30(10-12-31)23-20-14-21(17-5-4-8-25-15-17)29-22(20)26-16-27-23/h3-8,13-16H,2,9-12H2,1H3,(H,28,32)(H,26,27,29) QCXXZHLEQSZCFR-UHFFFAOYSA-N 368959 N-(2-chlorophenyl)-4-[6-(3-pyridyl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]piperazine-1- carboxamide::US10227357, Compound P-0220 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368959 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368959&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114833 402365758 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729025 Fc1ccc(CNC(=O)N2CCN(CC2)c2ncnc3[nH]c(cc23)-c2cccnc2)cc1 InChI=1S/C23H22FN7O/c24-18-5-3-16(4-6-18)13-26-23(32)31-10-8-30(9-11-31)22-19-12-20(17-2-1-7-25-14-17)29-21(19)27-15-28-22/h1-7,12,14-15H,8-11,13H2,(H,26,32)(H,27,28,29) VAZWPHJNPAQRQY-UHFFFAOYSA-N 368960 N-(3-ethoxyphenyl)-4-[6-(3-pyridyl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]piperazine-1- carboxamide::US10227357, Compound P-0221 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368960 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368960&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114882 402365759 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729026 Fc1ccc(CNC(=O)N2CCN(CC2)c2ncnc3[nH]c(cc23)-c2cccnc2)cc1 InChI=1S/C23H22FN7O/c24-18-5-3-16(4-6-18)13-26-23(32)31-10-8-30(9-11-31)22-19-12-20(17-2-1-7-25-14-17)29-21(19)27-15-28-22/h1-7,12,14-15H,8-11,13H2,(H,26,32)(H,27,28,29) VAZWPHJNPAQRQY-UHFFFAOYSA-N 368960 N-(3-ethoxyphenyl)-4-[6-(3-pyridyl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]piperazine-1- carboxamide::US10227357, Compound P-0221 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368960 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368960&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114882 402365759 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729027 FC(F)(F)c1cccc(NC(=O)N2CCN(CC2)c2ncnc3[nH]c(cc23)-c2cccnc2)c1 InChI=1S/C23H20F3N7O/c24-23(25,26)16-4-1-5-17(11-16)30-22(34)33-9-7-32(8-10-33)21-18-12-19(15-3-2-6-27-13-15)31-20(18)28-14-29-21/h1-6,11-14H,7-10H2,(H,30,34)(H,28,29,31) JJPSVXOVJADXOK-UHFFFAOYSA-N 368961 N-[(4-fluorophenyl)methyl]-4-[6-(3-pyridyl)- 7H-pyrrolo[2,3-d]pyrimidin-4-yl]piperazine-1- carboxamide::US10227357, Compound P-0222 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368961 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368961&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114593 402365760 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729028 FC(F)(F)c1cccc(NC(=O)N2CCN(CC2)c2ncnc3[nH]c(cc23)-c2cccnc2)c1 InChI=1S/C23H20F3N7O/c24-23(25,26)16-4-1-5-17(11-16)30-22(34)33-9-7-32(8-10-33)21-18-12-19(15-3-2-6-27-13-15)31-20(18)28-14-29-21/h1-6,11-14H,7-10H2,(H,30,34)(H,28,29,31) JJPSVXOVJADXOK-UHFFFAOYSA-N 368961 N-[(4-fluorophenyl)methyl]-4-[6-(3-pyridyl)- 7H-pyrrolo[2,3-d]pyrimidin-4-yl]piperazine-1- carboxamide::US10227357, Compound P-0222 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368961 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368961&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114593 402365760 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729029 FC(F)(F)Oc1ccc(NC(=O)N2CCN(CC2)c2ncnc3[nH]c(cc23)-c2cccnc2)cc1 InChI=1S/C23H20F3N7O2/c24-23(25,26)35-17-5-3-16(4-6-17)30-22(34)33-10-8-32(9-11-33)21-18-12-19(15-2-1-7-27-13-15)31-20(18)28-14-29-21/h1-7,12-14H,8-11H2,(H,30,34)(H,28,29,31) OVOMZQRCSVBNRV-UHFFFAOYSA-N 368962 4-[6-(3-pyridyl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]-N-[3-(trifluoromethyl)phenyl]piperazine- 1-carboxamide::US10227357, Compound P-0223 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368962 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368962&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114293 402365761 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729030 FC(F)(F)Oc1ccc(NC(=O)N2CCN(CC2)c2ncnc3[nH]c(cc23)-c2cccnc2)cc1 InChI=1S/C23H20F3N7O2/c24-23(25,26)35-17-5-3-16(4-6-17)30-22(34)33-10-8-32(9-11-33)21-18-12-19(15-2-1-7-27-13-15)31-20(18)28-14-29-21/h1-7,12-14H,8-11H2,(H,30,34)(H,28,29,31) OVOMZQRCSVBNRV-UHFFFAOYSA-N 368962 4-[6-(3-pyridyl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]-N-[3-(trifluoromethyl)phenyl]piperazine- 1-carboxamide::US10227357, Compound P-0223 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368962 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368962&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114293 402365761 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729031 CCOc1ccc(NC(=O)N2CCN(CC2)c2ncnc3[nH]c(cc23)-c2cccnc2)cc1 InChI=1S/C24H25N7O2/c1-2-33-19-7-5-18(6-8-19)28-24(32)31-12-10-30(11-13-31)23-20-14-21(17-4-3-9-25-15-17)29-22(20)26-16-27-23/h3-9,14-16H,2,10-13H2,1H3,(H,28,32)(H,26,27,29) FMLOELZMOVVPBY-UHFFFAOYSA-N 368963 4-[6-(3-pyridyl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]-N-[4-(trifluoromethoxy)phenyl]piperazine- 1-carboxamide::US10227357, Compound P-0224 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368963 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368963&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114821 402365762 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729032 CCOc1ccc(NC(=O)N2CCN(CC2)c2ncnc3[nH]c(cc23)-c2cccnc2)cc1 InChI=1S/C24H25N7O2/c1-2-33-19-7-5-18(6-8-19)28-24(32)31-12-10-30(11-13-31)23-20-14-21(17-4-3-9-25-15-17)29-22(20)26-16-27-23/h3-9,14-16H,2,10-13H2,1H3,(H,28,32)(H,26,27,29) FMLOELZMOVVPBY-UHFFFAOYSA-N 368963 4-[6-(3-pyridyl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]-N-[4-(trifluoromethoxy)phenyl]piperazine- 1-carboxamide::US10227357, Compound P-0224 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368963 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368963&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114821 402365762 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729033 Fc1ccc(CNC(=O)N2CCN(CC2)c2ncnc3[nH]cc(-c4ccccc4)c23)cc1 InChI=1S/C24H23FN6O/c25-19-8-6-17(7-9-19)14-27-24(32)31-12-10-30(11-13-31)23-21-20(18-4-2-1-3-5-18)15-26-22(21)28-16-29-23/h1-9,15-16H,10-14H2,(H,27,32)(H,26,28,29) HUIWDIPBDXHLHP-UHFFFAOYSA-N 368964 N-(4-ethoxyphenyl)-4-[6-(3-pyridyl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]piperazine-1- carboxamide::US10227357, Compound P-0225 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368964 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368964&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114960 402365763 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729034 Fc1ccc(CNC(=O)N2CCN(CC2)c2ncnc3[nH]cc(-c4ccccc4)c23)cc1 InChI=1S/C24H23FN6O/c25-19-8-6-17(7-9-19)14-27-24(32)31-12-10-30(11-13-31)23-21-20(18-4-2-1-3-5-18)15-26-22(21)28-16-29-23/h1-9,15-16H,10-14H2,(H,27,32)(H,26,28,29) HUIWDIPBDXHLHP-UHFFFAOYSA-N 368964 N-(4-ethoxyphenyl)-4-[6-(3-pyridyl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]piperazine-1- carboxamide::US10227357, Compound P-0225 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368964 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368964&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114960 402365763 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729035 COc1ccc(NC(=O)N2CCN(CC2)c2ncnc3[nH]cc(-c4ccccc4)c23)cc1 InChI=1S/C24H24N6O2/c1-32-19-9-7-18(8-10-19)28-24(31)30-13-11-29(12-14-30)23-21-20(17-5-3-2-4-6-17)15-25-22(21)26-16-27-23/h2-10,15-16H,11-14H2,1H3,(H,28,31)(H,25,26,27) HCQHLCMVIFJCJG-UHFFFAOYSA-N 368965 N-[(4-fluorophenyl)methyl]-4-(5-phenyl-7H- pyrrolo[2,3-d]pyrimidin-4-yl)piperazine-1- carboxamide::US10227357, Compound P-0226 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368965 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368965&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115033 402365764 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729036 COc1ccc(NC(=O)N2CCN(CC2)c2ncnc3[nH]cc(-c4ccccc4)c23)cc1 InChI=1S/C24H24N6O2/c1-32-19-9-7-18(8-10-19)28-24(31)30-13-11-29(12-14-30)23-21-20(17-5-3-2-4-6-17)15-25-22(21)26-16-27-23/h2-10,15-16H,11-14H2,1H3,(H,28,31)(H,25,26,27) HCQHLCMVIFJCJG-UHFFFAOYSA-N 368965 N-[(4-fluorophenyl)methyl]-4-(5-phenyl-7H- pyrrolo[2,3-d]pyrimidin-4-yl)piperazine-1- carboxamide::US10227357, Compound P-0226 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368965 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368965&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115033 402365764 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729037 COc1cccc(NC(=O)N2CCN(CC2)c2ncnc3[nH]cc(-c4ccccc4)c23)c1 InChI=1S/C24H24N6O2/c1-32-19-9-5-8-18(14-19)28-24(31)30-12-10-29(11-13-30)23-21-20(17-6-3-2-4-7-17)15-25-22(21)26-16-27-23/h2-9,14-16H,10-13H2,1H3,(H,28,31)(H,25,26,27) XIUXNTHOTDJBRE-UHFFFAOYSA-N 368966 N-(4-methoxyphenyl)-4-(5-phenyl-7H- pyrrolo[2,3-d]pyrimidin-4-yl)piperazine-1- carboxamide::US10227357, Compound P-0227 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368966 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368966&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115325 402365765 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729038 COc1cccc(NC(=O)N2CCN(CC2)c2ncnc3[nH]cc(-c4ccccc4)c23)c1 InChI=1S/C24H24N6O2/c1-32-19-9-5-8-18(14-19)28-24(31)30-12-10-29(11-13-30)23-21-20(17-6-3-2-4-7-17)15-25-22(21)26-16-27-23/h2-9,14-16H,10-13H2,1H3,(H,28,31)(H,25,26,27) XIUXNTHOTDJBRE-UHFFFAOYSA-N 368966 N-(4-methoxyphenyl)-4-(5-phenyl-7H- pyrrolo[2,3-d]pyrimidin-4-yl)piperazine-1- carboxamide::US10227357, Compound P-0227 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368966 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368966&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115325 402365765 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729039 COc1cc(NC(=O)N2CCN(CC2)c2ncnc3[nH]c(cc23)-c2cccnc2)cc(OC)c1 InChI=1S/C24H25N7O3/c1-33-18-10-17(11-19(12-18)34-2)28-24(32)31-8-6-30(7-9-31)23-20-13-21(16-4-3-5-25-14-16)29-22(20)26-15-27-23/h3-5,10-15H,6-9H2,1-2H3,(H,28,32)(H,26,27,29) YDDIPDITCFOKCS-UHFFFAOYSA-N 368967 N-(3-methoxyphenyl)-4-(5-phenyl-7H- pyrrolo[2,3-d]pyrimidin-4-yl)piperazine-1- carboxamide::US10227357, Compound P-0228 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368967 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368967&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114782 402365766 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729040 COc1ccc(NC(=O)N2CCN(CC2)c2ncnc3[nH]c(cc23)-c2cccnc2)cc1 InChI=1S/C23H23N7O2/c1-32-18-6-4-17(5-7-18)27-23(31)30-11-9-29(10-12-30)22-19-13-20(16-3-2-8-24-14-16)28-21(19)25-15-26-22/h2-8,13-15H,9-12H2,1H3,(H,27,31)(H,25,26,28) FZDBWXDWTILNIE-UHFFFAOYSA-N 368968 N-(3,5-dimethoxyphenyl)-4-[6-(3-pyridyl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]piperazine-1- carboxamide::US10227357, Compound P-0229 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368968 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368968&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114634 402365767 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729041 COc1ccc(NC(=O)N2CCN(CC2)c2ncnc3[nH]c(cc23)-c2cccnc2)cc1 InChI=1S/C23H23N7O2/c1-32-18-6-4-17(5-7-18)27-23(31)30-11-9-29(10-12-30)22-19-13-20(16-3-2-8-24-14-16)28-21(19)25-15-26-22/h2-8,13-15H,9-12H2,1H3,(H,27,31)(H,25,26,28) FZDBWXDWTILNIE-UHFFFAOYSA-N 368968 N-(3,5-dimethoxyphenyl)-4-[6-(3-pyridyl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]piperazine-1- carboxamide::US10227357, Compound P-0229 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368968 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368968&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114634 402365767 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729042 COc1cccc(NC(=O)N2CCN(CC2)c2ncnc3[nH]c(cc23)-c2cccnc2)c1 InChI=1S/C23H23N7O2/c1-32-18-6-2-5-17(12-18)27-23(31)30-10-8-29(9-11-30)22-19-13-20(16-4-3-7-24-14-16)28-21(19)25-15-26-22/h2-7,12-15H,8-11H2,1H3,(H,27,31)(H,25,26,28) NRSGPSCRERWLOZ-UHFFFAOYSA-N 368969 N-(4-methoxyphenyl)-4-[6-(3-pyridyl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]piperazine-1- carboxamide::US10227357, Compound P-0230 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368969 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368969&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115474 402365768 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729043 COc1cccc(NC(=O)N2CCN(CC2)c2ncnc3[nH]c(cc23)-c2cccnc2)c1 InChI=1S/C23H23N7O2/c1-32-18-6-2-5-17(12-18)27-23(31)30-10-8-29(9-11-30)22-19-13-20(16-4-3-7-24-14-16)28-21(19)25-15-26-22/h2-7,12-15H,8-11H2,1H3,(H,27,31)(H,25,26,28) NRSGPSCRERWLOZ-UHFFFAOYSA-N 368969 N-(4-methoxyphenyl)-4-[6-(3-pyridyl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]piperazine-1- carboxamide::US10227357, Compound P-0230 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368969 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368969&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115474 402365768 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729044 CC(C)(C)OC(=O)N1CCN(CC1)c1ncnc2[nH]c(cc12)-c1cccnc1 InChI=1S/C20H24N6O2/c1-20(2,3)28-19(27)26-9-7-25(8-10-26)18-15-11-16(14-5-4-6-21-12-14)24-17(15)22-13-23-18/h4-6,11-13H,7-10H2,1-3H3,(H,22,23,24) YVUVFUTZVBNNTH-UHFFFAOYSA-N 368970 N-(3-methoxyphenyl)-4-[6-(3-pyridyl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]piperazine-1- carboxamide::US10227357, Compound P-0231 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368970 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368970&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114809 402365769 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729045 C1CN(CCN1)c1ncnc2[nH]ccc12 InChI=1S/C10H13N5/c1-2-12-9-8(1)10(14-7-13-9)15-5-3-11-4-6-15/h1-2,7,11H,3-6H2,(H,12,13,14) LZSXQBNNRGZPES-UHFFFAOYSA-N 50304819 4-(piperazin-1-yl)-7H-pyrrolo[2,3-d]pyrimidine::CHEMBL595554::US10227357, Compound P-0232 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50304819 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50304819&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 6J9 5J5X,5IZJ,5IZF,7OOW 18008465 104159180 CHEMBL595554 ZINC40448778 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729046 C1CN(CCN1)c1ncnc2[nH]ccc12 InChI=1S/C10H13N5/c1-2-12-9-8(1)10(14-7-13-9)15-5-3-11-4-6-15/h1-2,7,11H,3-6H2,(H,12,13,14) LZSXQBNNRGZPES-UHFFFAOYSA-N 50304819 4-(piperazin-1-yl)-7H-pyrrolo[2,3-d]pyrimidine::CHEMBL595554::US10227357, Compound P-0232 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50304819 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50304819&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 6J9 5J5X,5IZJ,5IZF,7OOW 18008465 104159180 CHEMBL595554 ZINC40448778 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729047 COc1ccc(cc1)C(=O)N1CCN(CC1)c1ncnc2[nH]ccc12 InChI=1S/C18H19N5O2/c1-25-14-4-2-13(3-5-14)18(24)23-10-8-22(9-11-23)17-15-6-7-19-16(15)20-12-21-17/h2-7,12H,8-11H2,1H3,(H,19,20,21) DHQVNRGMPSBQNS-UHFFFAOYSA-N 368972 4-piperazin-1-yl-7H-pyrrolo[2,3-d]pyrimidine::US10227357, Compound P-0233 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368972 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368972&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115211 402365771 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729048 COc1ccc(cc1)C(=O)N1CCN(CC1)c1ncnc2[nH]ccc12 InChI=1S/C18H19N5O2/c1-25-14-4-2-13(3-5-14)18(24)23-10-8-22(9-11-23)17-15-6-7-19-16(15)20-12-21-17/h2-7,12H,8-11H2,1H3,(H,19,20,21) DHQVNRGMPSBQNS-UHFFFAOYSA-N 368972 4-piperazin-1-yl-7H-pyrrolo[2,3-d]pyrimidine::US10227357, Compound P-0233 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368972 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368972&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115211 402365771 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729049 COc1ccc(NC(=O)N2CCN(CC2)c2ncnc3[nH]ccc23)cc1 InChI=1S/C18H20N6O2/c1-26-14-4-2-13(3-5-14)22-18(25)24-10-8-23(9-11-24)17-15-6-7-19-16(15)20-12-21-17/h2-7,12H,8-11H2,1H3,(H,22,25)(H,19,20,21) PLDGWUVNKGXAGP-UHFFFAOYSA-N 368973 (4-methoxyphenyl)-[4-(7H-pyrrolo[2,3- d]pyrimidin-4-yl)piperazin-1-yl]methanone::US10227357, Compound P-0234 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368973 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368973&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114638 402365772 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729050 COc1ccc(NC(=O)N2CCN(CC2)c2ncnc3[nH]ccc23)cc1 InChI=1S/C18H20N6O2/c1-26-14-4-2-13(3-5-14)22-18(25)24-10-8-23(9-11-24)17-15-6-7-19-16(15)20-12-21-17/h2-7,12H,8-11H2,1H3,(H,22,25)(H,19,20,21) PLDGWUVNKGXAGP-UHFFFAOYSA-N 368973 (4-methoxyphenyl)-[4-(7H-pyrrolo[2,3- d]pyrimidin-4-yl)piperazin-1-yl]methanone::US10227357, Compound P-0234 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368973 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368973&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114638 402365772 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729051 CCCNC(=O)N1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccccc1 InChI=1S/C20H24N6O/c1-2-8-21-20(27)26-11-9-25(10-12-26)19-16-13-17(15-6-4-3-5-7-15)24-18(16)22-14-23-19/h3-7,13-14H,2,8-12H2,1H3,(H,21,27)(H,22,23,24) DGTCXNPVTYFIMK-UHFFFAOYSA-N 368974 N-(4-methoxyphenyl)-4-(7H-pyrrolo[2,3- d]pyrimidin-4-yl)piperazine-1-carboxamide::US10227357, Compound P-0235 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368974 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368974&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115247 402365773 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729052 CCCNC(=O)N1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccccc1 InChI=1S/C20H24N6O/c1-2-8-21-20(27)26-11-9-25(10-12-26)19-16-13-17(15-6-4-3-5-7-15)24-18(16)22-14-23-19/h3-7,13-14H,2,8-12H2,1H3,(H,21,27)(H,22,23,24) DGTCXNPVTYFIMK-UHFFFAOYSA-N 368974 N-(4-methoxyphenyl)-4-(7H-pyrrolo[2,3- d]pyrimidin-4-yl)piperazine-1-carboxamide::US10227357, Compound P-0235 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368974 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368974&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115247 402365773 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729053 Clc1ccccc1NC(=O)N1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccccc1 InChI=1S/C23H21ClN6O/c24-18-8-4-5-9-19(18)28-23(31)30-12-10-29(11-13-30)22-17-14-20(16-6-2-1-3-7-16)27-21(17)25-15-26-22/h1-9,14-15H,10-13H2,(H,28,31)(H,25,26,27) SHQPFSJNZOCWJI-UHFFFAOYSA-N 368975 4-(6-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)- N-propyl-piperazine-1-carboxamide::US10227357, Compound P-0236 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368975 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368975&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114891 402365774 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729054 Clc1ccccc1NC(=O)N1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccccc1 InChI=1S/C23H21ClN6O/c24-18-8-4-5-9-19(18)28-23(31)30-12-10-29(11-13-30)22-17-14-20(16-6-2-1-3-7-16)27-21(17)25-15-26-22/h1-9,14-15H,10-13H2,(H,28,31)(H,25,26,27) SHQPFSJNZOCWJI-UHFFFAOYSA-N 368975 4-(6-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)- N-propyl-piperazine-1-carboxamide::US10227357, Compound P-0236 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368975 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368975&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114891 402365774 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729055 COc1cccc(NC(=O)N2CCN(CC2)c2ncnc3[nH]c(cc23)-c2ccccc2)c1 InChI=1S/C24H24N6O2/c1-32-19-9-5-8-18(14-19)27-24(31)30-12-10-29(11-13-30)23-20-15-21(17-6-3-2-4-7-17)28-22(20)25-16-26-23/h2-9,14-16H,10-13H2,1H3,(H,27,31)(H,25,26,28) NHNDLKZODNGPDK-UHFFFAOYSA-N 368976 N-(2-chlorophenyl)-4-(6-phenyl-7H- pyrrolo[2,3-d]pyrimidin-4-yl)piperazine-1- carboxamide::US10227357, Compound P-0237 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368976 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368976&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90113968 402365775 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729056 COc1cccc(NC(=O)N2CCN(CC2)c2ncnc3[nH]c(cc23)-c2ccccc2)c1 InChI=1S/C24H24N6O2/c1-32-19-9-5-8-18(14-19)27-24(31)30-12-10-29(11-13-30)23-20-15-21(17-6-3-2-4-7-17)28-22(20)25-16-26-23/h2-9,14-16H,10-13H2,1H3,(H,27,31)(H,25,26,28) NHNDLKZODNGPDK-UHFFFAOYSA-N 368976 N-(2-chlorophenyl)-4-(6-phenyl-7H- pyrrolo[2,3-d]pyrimidin-4-yl)piperazine-1- carboxamide::US10227357, Compound P-0237 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368976 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368976&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90113968 402365775 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729057 COc1cc(NC(=O)N2CCN(CC2)c2ncnc3[nH]c(cc23)-c2ccccc2)cc(OC)c1 InChI=1S/C25H26N6O3/c1-33-19-12-18(13-20(14-19)34-2)28-25(32)31-10-8-30(9-11-31)24-21-15-22(17-6-4-3-5-7-17)29-23(21)26-16-27-24/h3-7,12-16H,8-11H2,1-2H3,(H,28,32)(H,26,27,29) NGKVRPMNOQBGNK-UHFFFAOYSA-N 368977 N-(3-methoxyphenyl)-4-(6-phenyl-7H- pyrrolo[2,3-d]pyrimidin-4-yl)piperazine-1- carboxamide::US10227357, Compound P-0238 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368977 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368977&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115078 402365776 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729058 COc1ccc(NC(=O)N2CCN(CC2)c2ncnc3[nH]c(cc23)-c2ccccc2)cc1 InChI=1S/C24H24N6O2/c1-32-19-9-7-18(8-10-19)27-24(31)30-13-11-29(12-14-30)23-20-15-21(17-5-3-2-4-6-17)28-22(20)25-16-26-23/h2-10,15-16H,11-14H2,1H3,(H,27,31)(H,25,26,28) WLQFFHNUSDMQFG-UHFFFAOYSA-N 368978 N-(3,5-dimethoxyphenyl)-4-(6-phenyl-7H- pyrrolo[2,3-d]pyrimidin-4-yl)piperazine-1- carboxamide::US10227357, Compound P-0239 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368978 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368978&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115344 402365777 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729059 COc1ccc(NC(=O)N2CCN(CC2)c2ncnc3[nH]c(cc23)-c2ccccc2)cc1 InChI=1S/C24H24N6O2/c1-32-19-9-7-18(8-10-19)27-24(31)30-13-11-29(12-14-30)23-20-15-21(17-5-3-2-4-6-17)28-22(20)25-16-26-23/h2-10,15-16H,11-14H2,1H3,(H,27,31)(H,25,26,28) WLQFFHNUSDMQFG-UHFFFAOYSA-N 368978 N-(3,5-dimethoxyphenyl)-4-(6-phenyl-7H- pyrrolo[2,3-d]pyrimidin-4-yl)piperazine-1- carboxamide::US10227357, Compound P-0239 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368978 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368978&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115344 402365777 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729060 CCCNS(=O)(=O)N1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccccc1 InChI=1S/C19H24N6O2S/c1-2-8-22-28(26,27)25-11-9-24(10-12-25)19-16-13-17(15-6-4-3-5-7-15)23-18(16)20-14-21-19/h3-7,13-14,22H,2,8-12H2,1H3,(H,20,21,23) UHQIHKVKMIGOGP-UHFFFAOYSA-N 368979 N-(4-methoxyphenyl)-4-(6-phenyl-7H- pyrrolo[2,3-d]pyrimidin-4-yl)piperazine-1- carboxamide::US10227357, Compound P-0240 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368979 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368979&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114674 402365778 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729061 Fc1ccc(CNC(=O)N2CCN(CC2)c2ncnc3[nH]c(cc23)-c2ccccc2)cc1 InChI=1S/C24H23FN6O/c25-19-8-6-17(7-9-19)15-26-24(32)31-12-10-30(11-13-31)23-20-14-21(18-4-2-1-3-5-18)29-22(20)27-16-28-23/h1-9,14,16H,10-13,15H2,(H,26,32)(H,27,28,29) ADHZFMCNUFNUTM-UHFFFAOYSA-N 368980 4-(6-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)- N-propyl-piperazine-1-sulfonamide::US10227357, Compound P-0241 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368980 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368980&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114562 402365779 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729062 Fc1ccc(CNC(=O)N2CCN(CC2)c2ncnc3[nH]c(cc23)-c2ccccc2)cc1 InChI=1S/C24H23FN6O/c25-19-8-6-17(7-9-19)15-26-24(32)31-12-10-30(11-13-31)23-20-14-21(18-4-2-1-3-5-18)29-22(20)27-16-28-23/h1-9,14,16H,10-13,15H2,(H,26,32)(H,27,28,29) ADHZFMCNUFNUTM-UHFFFAOYSA-N 368980 4-(6-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)- N-propyl-piperazine-1-sulfonamide::US10227357, Compound P-0241 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368980 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368980&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114562 402365779 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729063 Fc1ccc(NC(=O)N2CCN(CC2)c2ncnc3[nH]c(cc23)-c2ccccc2)cc1 InChI=1S/C23H21FN6O/c24-17-6-8-18(9-7-17)27-23(31)30-12-10-29(11-13-30)22-19-14-20(16-4-2-1-3-5-16)28-21(19)25-15-26-22/h1-9,14-15H,10-13H2,(H,27,31)(H,25,26,28) PWAPAQLSFMTKJO-UHFFFAOYSA-N 368981 N-[(4-fluorophenyl)methyl]-4-(6-phenyl-7H- pyrrolo[2,3-d]pyrimidin-4-yl)piperazine-1- carboxamide::US10227357, Compound P-0242 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368981 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368981&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114837 402365780 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729064 Fc1ccc(NC(=O)N2CCN(CC2)c2ncnc3[nH]c(cc23)-c2ccccc2)cc1 InChI=1S/C23H21FN6O/c24-17-6-8-18(9-7-17)27-23(31)30-12-10-29(11-13-30)22-19-14-20(16-4-2-1-3-5-16)28-21(19)25-15-26-22/h1-9,14-15H,10-13H2,(H,27,31)(H,25,26,28) PWAPAQLSFMTKJO-UHFFFAOYSA-N 368981 N-[(4-fluorophenyl)methyl]-4-(6-phenyl-7H- pyrrolo[2,3-d]pyrimidin-4-yl)piperazine-1- carboxamide::US10227357, Compound P-0242 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368981 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368981&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114837 402365780 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729065 CC(C)(C)OC(=O)N1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccccc1 InChI=1S/C21H25N5O2/c1-21(2,3)28-20(27)26-11-9-25(10-12-26)19-16-13-17(15-7-5-4-6-8-15)24-18(16)22-14-23-19/h4-8,13-14H,9-12H2,1-3H3,(H,22,23,24) PPMWVCGCSKIEIF-UHFFFAOYSA-N 368982 4-(6-iodo-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-N- (4-methoxyphenyl)piperazine-1-carboxamide::US10227357, Compound P-0244 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368982 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368982&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90134911 402365781 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729066 COc1cc2ncnc(-c3ccc(cc3F)S(=O)(=O)Nc3ccc(Cl)cc3)c2cc1OCCCN1CCOCC1 InChI=1S/C28H28ClFN4O5S/c1-37-26-17-25-23(16-27(26)39-12-2-9-34-10-13-38-14-11-34)28(32-18-31-25)22-8-7-21(15-24(22)30)40(35,36)33-20-5-3-19(29)4-6-20/h3-8,15-18,33H,2,9-14H2,1H3 VDJARNCZNZEFHT-UHFFFAOYSA-N 368983 N-(4-chlorophenyl)-3-fluoro-4-[7- methoxy-6-(3- morpholinopropoxy)quinazolin-4- yl]benzenesulfonamide::US10227357, Compound P-0247 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368983 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368983&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114499 402365782 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729067 COc1cc2ncnc(-c3ccc(cc3F)S(=O)(=O)Nc3ccc(Cl)cc3)c2cc1OCCCN1CCOCC1 InChI=1S/C28H28ClFN4O5S/c1-37-26-17-25-23(16-27(26)39-12-2-9-34-10-13-38-14-11-34)28(32-18-31-25)22-8-7-21(15-24(22)30)40(35,36)33-20-5-3-19(29)4-6-20/h3-8,15-18,33H,2,9-14H2,1H3 VDJARNCZNZEFHT-UHFFFAOYSA-N 368983 N-(4-chlorophenyl)-3-fluoro-4-[7- methoxy-6-(3- morpholinopropoxy)quinazolin-4- yl]benzenesulfonamide::US10227357, Compound P-0247 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368983 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368983&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114499 402365782 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729068 COc1cc2ncnc(-c3ccc(cc3F)S(=O)(=O)Nc3ccc(F)cc3)c2cc1OCCCN1CCOCC1 InChI=1S/C28H28F2N4O5S/c1-37-26-17-25-23(16-27(26)39-12-2-9-34-10-13-38-14-11-34)28(32-18-31-25)22-8-7-21(15-24(22)30)40(35,36)33-20-5-3-19(29)4-6-20/h3-8,15-18,33H,2,9-14H2,1H3 JYYGIKMZCTVGKE-UHFFFAOYSA-N 368984 3-fluoro-N-(4-fluorophenyl)-4-[7- methoxy-6-(3- morpholinopropoxy)quinazolin-4- yl]benzenesulfonamide::US10227357, Compound P-0248 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368984 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368984&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114619 402365783 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729069 COc1cc2ncnc(-c3ccc(cc3F)S(=O)(=O)Nc3ccc(F)cc3)c2cc1OCCCN1CCOCC1 InChI=1S/C28H28F2N4O5S/c1-37-26-17-25-23(16-27(26)39-12-2-9-34-10-13-38-14-11-34)28(32-18-31-25)22-8-7-21(15-24(22)30)40(35,36)33-20-5-3-19(29)4-6-20/h3-8,15-18,33H,2,9-14H2,1H3 JYYGIKMZCTVGKE-UHFFFAOYSA-N 368984 3-fluoro-N-(4-fluorophenyl)-4-[7- methoxy-6-(3- morpholinopropoxy)quinazolin-4- yl]benzenesulfonamide::US10227357, Compound P-0248 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368984 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368984&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114619 402365783 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729070 COc1ccc(cc1)S(=O)(=O)Nc1ccc(c(F)c1)-c1ncnc2cc(OC)c(OCCCN3CCOCC3)cc12 InChI=1S/C29H31FN4O6S/c1-37-21-5-7-22(8-6-21)41(35,36)33-20-4-9-23(25(30)16-20)29-24-17-28(27(38-2)18-26(24)31-19-32-29)40-13-3-10-34-11-14-39-15-12-34/h4-9,16-19,33H,3,10-15H2,1-2H3 VBLUBCSUZVXTMJ-UHFFFAOYSA-N 368985 N-[3-fluoro-4-[7-methoxy-6-(3- morpholinopropoxy)quinazolin-4- yl]phenyl]-4-methoxy- benzenesulfonamide::US10227357, Compound P-0249 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368985 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368985&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115175 402365784 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729071 COc1ccc(cc1)S(=O)(=O)Nc1ccc(c(F)c1)-c1ncnc2cc(OC)c(OCCCN3CCOCC3)cc12 InChI=1S/C29H31FN4O6S/c1-37-21-5-7-22(8-6-21)41(35,36)33-20-4-9-23(25(30)16-20)29-24-17-28(27(38-2)18-26(24)31-19-32-29)40-13-3-10-34-11-14-39-15-12-34/h4-9,16-19,33H,3,10-15H2,1-2H3 VBLUBCSUZVXTMJ-UHFFFAOYSA-N 368985 N-[3-fluoro-4-[7-methoxy-6-(3- morpholinopropoxy)quinazolin-4- yl]phenyl]-4-methoxy- benzenesulfonamide::US10227357, Compound P-0249 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368985 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368985&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115175 402365784 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729072 COc1cc2ncnc(-c3ccc(NS(=O)(=O)c4ccc(Cl)cc4)cc3F)c2cc1OCCCN1CCOCC1 InChI=1S/C28H28ClFN4O5S/c1-37-26-17-25-23(16-27(26)39-12-2-9-34-10-13-38-14-11-34)28(32-18-31-25)22-8-5-20(15-24(22)30)33-40(35,36)21-6-3-19(29)4-7-21/h3-8,15-18,33H,2,9-14H2,1H3 NTEFUBQWDUUBNO-UHFFFAOYSA-N 368986 4-chloro-N-[3-fluoro-4-[7-methoxy-6- (3-morpholinopropoxy)quinazolin-4- yl]phenyl]benzenesulfonamide::US10227357, Compound P-0250 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368986 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368986&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114605 402365785 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729073 COc1cc2ncnc(-c3ccc(NS(=O)(=O)c4ccc(Cl)cc4)cc3F)c2cc1OCCCN1CCOCC1 InChI=1S/C28H28ClFN4O5S/c1-37-26-17-25-23(16-27(26)39-12-2-9-34-10-13-38-14-11-34)28(32-18-31-25)22-8-5-20(15-24(22)30)33-40(35,36)21-6-3-19(29)4-7-21/h3-8,15-18,33H,2,9-14H2,1H3 NTEFUBQWDUUBNO-UHFFFAOYSA-N 368986 4-chloro-N-[3-fluoro-4-[7-methoxy-6- (3-morpholinopropoxy)quinazolin-4- yl]phenyl]benzenesulfonamide::US10227357, Compound P-0250 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368986 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368986&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114605 402365785 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729074 COc1cc2ncnc(-c3ccc(NS(=O)(=O)C4CC4)cc3F)c2cc1OCCCN1CCOCC1 InChI=1S/C25H29FN4O5S/c1-33-23-15-22-20(14-24(23)35-10-2-7-30-8-11-34-12-9-30)25(28-16-27-22)19-6-3-17(13-21(19)26)29-36(31,32)18-4-5-18/h3,6,13-16,18,29H,2,4-5,7-12H2,1H3 ZACKEGOJGJLAKP-UHFFFAOYSA-N 368987 N-[3-fluoro-4-[7-methoxy-6-(3- morpholinopropoxy)quinazolin-4- yl]phenyl]cyclopropanesulfonamide::US10227357, Compound P-0251 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368987 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368987&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114842 402365786 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729075 COc1cc2ncnc(-c3ccc(NS(=O)(=O)C4CC4)cc3F)c2cc1OCCCN1CCOCC1 InChI=1S/C25H29FN4O5S/c1-33-23-15-22-20(14-24(23)35-10-2-7-30-8-11-34-12-9-30)25(28-16-27-22)19-6-3-17(13-21(19)26)29-36(31,32)18-4-5-18/h3,6,13-16,18,29H,2,4-5,7-12H2,1H3 ZACKEGOJGJLAKP-UHFFFAOYSA-N 368987 N-[3-fluoro-4-[7-methoxy-6-(3- morpholinopropoxy)quinazolin-4- yl]phenyl]cyclopropanesulfonamide::US10227357, Compound P-0251 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368987 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368987&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114842 402365786 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729076 COc1cc2ncnc(-c3ccc(NS(C)(=O)=O)cc3F)c2cc1OCCCN1CCOCC1 InChI=1S/C23H27FN4O5S/c1-31-21-14-20-18(13-22(21)33-9-3-6-28-7-10-32-11-8-28)23(26-15-25-20)17-5-4-16(12-19(17)24)27-34(2,29)30/h4-5,12-15,27H,3,6-11H2,1-2H3 PLQDXTLFMYCSLJ-UHFFFAOYSA-N 368988 N-[3-fluoro-4-[7-methoxy-6-(3- morpholinopropoxy)quinazolin-4- yl]phenyl]methanesulfonamide::US10227357, Compound P-0252 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368988 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368988&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114288 402365787 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729077 COc1cc2ncnc(-c3ccc(NS(C)(=O)=O)cc3F)c2cc1OCCCN1CCOCC1 InChI=1S/C23H27FN4O5S/c1-31-21-14-20-18(13-22(21)33-9-3-6-28-7-10-32-11-8-28)23(26-15-25-20)17-5-4-16(12-19(17)24)27-34(2,29)30/h4-5,12-15,27H,3,6-11H2,1-2H3 PLQDXTLFMYCSLJ-UHFFFAOYSA-N 368988 N-[3-fluoro-4-[7-methoxy-6-(3- morpholinopropoxy)quinazolin-4- yl]phenyl]methanesulfonamide::US10227357, Compound P-0252 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368988 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368988&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114288 402365787 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729078 COc1cc2c(ncnc2cc1OCCCN1CCCCC1)-c1ccc(NS(=O)(=O)N2CCCC2)cc1F InChI=1S/C27H34FN5O4S/c1-36-25-17-22-24(18-26(25)37-15-7-12-32-10-3-2-4-11-32)29-19-30-27(22)21-9-8-20(16-23(21)28)31-38(34,35)33-13-5-6-14-33/h8-9,16-19,31H,2-7,10-15H2,1H3 OIPFOIZYMZHISK-UHFFFAOYSA-N 368989 N-[3-fluoro-4-[6-methoxy-7-[3-(1- piperidyl)propoxy]quinazolin-4- yl]phenyl]pyrrolidine-1-sulfonamide::US10227357, Compound P-0253 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368989 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368989&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114402 402365788 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729079 COc1cc2c(ncnc2cc1OCCCN1CCCCC1)-c1ccc(NS(=O)(=O)N2CCCC2)cc1F InChI=1S/C27H34FN5O4S/c1-36-25-17-22-24(18-26(25)37-15-7-12-32-10-3-2-4-11-32)29-19-30-27(22)21-9-8-20(16-23(21)28)31-38(34,35)33-13-5-6-14-33/h8-9,16-19,31H,2-7,10-15H2,1H3 OIPFOIZYMZHISK-UHFFFAOYSA-N 368989 N-[3-fluoro-4-[6-methoxy-7-[3-(1- piperidyl)propoxy]quinazolin-4- yl]phenyl]pyrrolidine-1-sulfonamide::US10227357, Compound P-0253 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368989 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368989&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114402 402365788 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729080 COc1cc2c(ncnc2cc1OCCCN1CCCCC1)-c1ccc(NS(C)(=O)=O)cc1F InChI=1S/C24H29FN4O4S/c1-32-22-14-19-21(15-23(22)33-12-6-11-29-9-4-3-5-10-29)26-16-27-24(19)18-8-7-17(13-20(18)25)28-34(2,30)31/h7-8,13-16,28H,3-6,9-12H2,1-2H3 AVVMMAHIJPBRMN-UHFFFAOYSA-N 368990 1,1,1-trideuterio-N-[3-fluoro-4-[6- methoxy-7-[3-(1- piperidyl)propoxy]quinazolin-4- yl]phenyl]methanesulfonamide::US10227357, Compound P-0254::US10227357, Compound P-0258 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368990 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368990&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115176 402365789 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729081 COc1cc2c(ncnc2cc1OCCCN1CCCCC1)-c1ccc(NS(C)(=O)=O)cc1F InChI=1S/C24H29FN4O4S/c1-32-22-14-19-21(15-23(22)33-12-6-11-29-9-4-3-5-10-29)26-16-27-24(19)18-8-7-17(13-20(18)25)28-34(2,30)31/h7-8,13-16,28H,3-6,9-12H2,1-2H3 AVVMMAHIJPBRMN-UHFFFAOYSA-N 368990 1,1,1-trideuterio-N-[3-fluoro-4-[6- methoxy-7-[3-(1- piperidyl)propoxy]quinazolin-4- yl]phenyl]methanesulfonamide::US10227357, Compound P-0254::US10227357, Compound P-0258 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368990 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368990&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115176 402365789 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729082 COc1ccc(cc1)S(=O)(=O)Nc1ccc(c(F)c1)-c1ncnc2cc(OCCCN3CCCCC3)c(OC)cc12 InChI=1S/C30H33FN4O5S/c1-38-22-8-10-23(11-9-22)41(36,37)34-21-7-12-24(26(31)17-21)30-25-18-28(39-2)29(19-27(25)32-20-33-30)40-16-6-15-35-13-4-3-5-14-35/h7-12,17-20,34H,3-6,13-16H2,1-2H3 FZUVKBRHAIGUSD-UHFFFAOYSA-N 368991 N-[3-fluoro-4-[6-methoxy-7-[3-(1- piperidyl)propoxy]quinazolin-4- yl]phenyl]-4-methoxy- benzenesulfonamide::US10227357, Compound P-0255 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368991 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368991&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114393 402365790 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729083 COc1ccc(cc1)S(=O)(=O)Nc1ccc(c(F)c1)-c1ncnc2cc(OCCCN3CCCCC3)c(OC)cc12 InChI=1S/C30H33FN4O5S/c1-38-22-8-10-23(11-9-22)41(36,37)34-21-7-12-24(26(31)17-21)30-25-18-28(39-2)29(19-27(25)32-20-33-30)40-16-6-15-35-13-4-3-5-14-35/h7-12,17-20,34H,3-6,13-16H2,1-2H3 FZUVKBRHAIGUSD-UHFFFAOYSA-N 368991 N-[3-fluoro-4-[6-methoxy-7-[3-(1- piperidyl)propoxy]quinazolin-4- yl]phenyl]-4-methoxy- benzenesulfonamide::US10227357, Compound P-0255 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368991 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368991&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114393 402365790 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729084 COc1cc2c(ncnc2cc1OCCCN1CCCCC1)-c1ccc(NS(=O)(=O)c2ccc(Cl)cc2)cc1F InChI=1S/C29H30ClFN4O4S/c1-38-27-17-24-26(18-28(27)39-15-5-14-35-12-3-2-4-13-35)32-19-33-29(24)23-11-8-21(16-25(23)31)34-40(36,37)22-9-6-20(30)7-10-22/h6-11,16-19,34H,2-5,12-15H2,1H3 RKLXAFMWZRSBJZ-UHFFFAOYSA-N 368992 4-chloro-N-[3-fluoro-4-[6-methoxy-7- [3-(1-piperidyl)propoxy]quinazolin-4- yl]phenyl]benzenesulfonamide::US10227357, Compound P-0256 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368992 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368992&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114814 402365791 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729085 COc1cc2c(ncnc2cc1OCCCN1CCCCC1)-c1ccc(NS(=O)(=O)c2ccc(Cl)cc2)cc1F InChI=1S/C29H30ClFN4O4S/c1-38-27-17-24-26(18-28(27)39-15-5-14-35-12-3-2-4-13-35)32-19-33-29(24)23-11-8-21(16-25(23)31)34-40(36,37)22-9-6-20(30)7-10-22/h6-11,16-19,34H,2-5,12-15H2,1H3 RKLXAFMWZRSBJZ-UHFFFAOYSA-N 368992 4-chloro-N-[3-fluoro-4-[6-methoxy-7- [3-(1-piperidyl)propoxy]quinazolin-4- yl]phenyl]benzenesulfonamide::US10227357, Compound P-0256 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368992 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368992&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114814 402365791 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729086 COc1cc2c(ncnc2cc1OCCCN1CCCCC1)-c1ccc(NS(=O)(=O)C2CC2)cc1F InChI=1S/C26H31FN4O4S/c1-34-24-15-21-23(16-25(24)35-13-5-12-31-10-3-2-4-11-31)28-17-29-26(21)20-9-6-18(14-22(20)27)30-36(32,33)19-7-8-19/h6,9,14-17,19,30H,2-5,7-8,10-13H2,1H3 ZXBGPZNXCICUPA-UHFFFAOYSA-N 368993 N-[3-fluoro-4-[6-methoxy-7-[3-(1- piperidyl)propoxy]quinazolin-4- yl]phenyl]cyclopropanesulfonamide::US10227357, Compound P-0257 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368993 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368993&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 86718040 402365792 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729087 COc1cc2c(ncnc2cc1OCCCN1CCCCC1)-c1ccc(NS(=O)(=O)C2CC2)cc1F InChI=1S/C26H31FN4O4S/c1-34-24-15-21-23(16-25(24)35-13-5-12-31-10-3-2-4-11-31)28-17-29-26(21)20-9-6-18(14-22(20)27)30-36(32,33)19-7-8-19/h6,9,14-17,19,30H,2-5,7-8,10-13H2,1H3 ZXBGPZNXCICUPA-UHFFFAOYSA-N 368993 N-[3-fluoro-4-[6-methoxy-7-[3-(1- piperidyl)propoxy]quinazolin-4- yl]phenyl]cyclopropanesulfonamide::US10227357, Compound P-0257 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368993 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368993&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 86718040 402365792 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729088 COc1cc2c(ncnc2cc1OCCCN1CCCCC1)-c1ccc(NS(C)(=O)=O)cc1F InChI=1S/C24H29FN4O4S/c1-32-22-14-19-21(15-23(22)33-12-6-11-29-9-4-3-5-10-29)26-16-27-24(19)18-8-7-17(13-20(18)25)28-34(2,30)31/h7-8,13-16,28H,3-6,9-12H2,1-2H3 AVVMMAHIJPBRMN-UHFFFAOYSA-N 368990 1,1,1-trideuterio-N-[3-fluoro-4-[6- methoxy-7-[3-(1- piperidyl)propoxy]quinazolin-4- yl]phenyl]methanesulfonamide::US10227357, Compound P-0254::US10227357, Compound P-0258 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368990 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368990&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115176 402365789 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729089 COc1cc2c(ncnc2cc1OCCCN1CCCCC1)-c1ccc(NS(C)(=O)=O)cc1F InChI=1S/C24H29FN4O4S/c1-32-22-14-19-21(15-23(22)33-12-6-11-29-9-4-3-5-10-29)26-16-27-24(19)18-8-7-17(13-20(18)25)28-34(2,30)31/h7-8,13-16,28H,3-6,9-12H2,1-2H3 AVVMMAHIJPBRMN-UHFFFAOYSA-N 368990 1,1,1-trideuterio-N-[3-fluoro-4-[6- methoxy-7-[3-(1- piperidyl)propoxy]quinazolin-4- yl]phenyl]methanesulfonamide::US10227357, Compound P-0254::US10227357, Compound P-0258 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368990 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368990&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115176 402365789 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729090 COCCOc1cc2ncnc(-c3ccc(NS(=O)(=O)c4ccc(OC(F)F)cc4)cc3F)c2cc1OCCOC InChI=1S/C27H26F3N3O7S/c1-36-9-11-38-24-14-21-23(15-25(24)39-12-10-37-2)31-16-32-26(21)20-8-3-17(13-22(20)28)33-41(34,35)19-6-4-18(5-7-19)40-27(29)30/h3-8,13-16,27,33H,9-12H2,1-2H3 NYOIXEMLJFYOFR-UHFFFAOYSA-N 368995 N-[4-[6,7-bis(2- methoxyethoxy)quinazolin-4-yl]-3- fluoro-phenyl]-4- (difluoromethoxy)benzenesulfonamide::US10227357, Compound P-0259 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368995 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368995&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115179 402365793 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729091 COCCOc1cc2ncnc(-c3ccc(NS(=O)(=O)c4ccc(OC(F)F)cc4)cc3F)c2cc1OCCOC InChI=1S/C27H26F3N3O7S/c1-36-9-11-38-24-14-21-23(15-25(24)39-12-10-37-2)31-16-32-26(21)20-8-3-17(13-22(20)28)33-41(34,35)19-6-4-18(5-7-19)40-27(29)30/h3-8,13-16,27,33H,9-12H2,1-2H3 NYOIXEMLJFYOFR-UHFFFAOYSA-N 368995 N-[4-[6,7-bis(2- methoxyethoxy)quinazolin-4-yl]-3- fluoro-phenyl]-4- (difluoromethoxy)benzenesulfonamide::US10227357, Compound P-0259 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368995 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368995&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115179 402365793 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729092 COCCOc1cc2ncnc(-c3ccc(NS(=O)(=O)c4cccc(F)c4)cc3F)c2cc1OCCOC InChI=1S/C26H25F2N3O6S/c1-34-8-10-36-24-14-21-23(15-25(24)37-11-9-35-2)29-16-30-26(21)20-7-6-18(13-22(20)28)31-38(32,33)19-5-3-4-17(27)12-19/h3-7,12-16,31H,8-11H2,1-2H3 NYLJAEBISDEHKX-UHFFFAOYSA-N 368996 N-[4-[6,7-bis(2- methoxyethoxy)quinazolin-4-yl]-3- fluoro-phenyl]-3-fluoro- benzenesulfonamide::US10227357, Compound P-0260 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368996 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368996&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114310 402365794 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729093 COCCOc1cc2ncnc(-c3ccc(NS(=O)(=O)c4cccc(F)c4)cc3F)c2cc1OCCOC InChI=1S/C26H25F2N3O6S/c1-34-8-10-36-24-14-21-23(15-25(24)37-11-9-35-2)29-16-30-26(21)20-7-6-18(13-22(20)28)31-38(32,33)19-5-3-4-17(27)12-19/h3-7,12-16,31H,8-11H2,1-2H3 NYLJAEBISDEHKX-UHFFFAOYSA-N 368996 N-[4-[6,7-bis(2- methoxyethoxy)quinazolin-4-yl]-3- fluoro-phenyl]-3-fluoro- benzenesulfonamide::US10227357, Compound P-0260 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368996 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368996&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114310 402365794 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729094 COCCOc1cc2ncnc(-c3ccc(NS(=O)(=O)c4ccc(Cl)cc4)cc3F)c2cc1OCCOC InChI=1S/C26H25ClFN3O6S/c1-34-9-11-36-24-14-21-23(15-25(24)37-12-10-35-2)29-16-30-26(21)20-8-5-18(13-22(20)28)31-38(32,33)19-6-3-17(27)4-7-19/h3-8,13-16,31H,9-12H2,1-2H3 OLWUXMQAHAHWGM-UHFFFAOYSA-N 368997 N-[4-[6,7-bis(2- methoxyethoxy)quinazolin-4-yl]-3- fluoro-phenyl]-4-chloro- benzenesulfonamide::US10227357, Compound P-0261 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368997 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368997&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114489 402365795 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729095 COCCOc1cc2ncnc(-c3ccc(NS(=O)(=O)c4ccc(Cl)cc4)cc3F)c2cc1OCCOC InChI=1S/C26H25ClFN3O6S/c1-34-9-11-36-24-14-21-23(15-25(24)37-12-10-35-2)29-16-30-26(21)20-8-5-18(13-22(20)28)31-38(32,33)19-6-3-17(27)4-7-19/h3-8,13-16,31H,9-12H2,1-2H3 OLWUXMQAHAHWGM-UHFFFAOYSA-N 368997 N-[4-[6,7-bis(2- methoxyethoxy)quinazolin-4-yl]-3- fluoro-phenyl]-4-chloro- benzenesulfonamide::US10227357, Compound P-0261 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368997 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368997&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114489 402365795 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729096 COCCOc1cc2ncnc(-c3ccc(NS(=O)(=O)c4ccc(OC)cc4)cc3F)c2cc1OCCOC InChI=1S/C27H28FN3O7S/c1-34-10-12-37-25-15-22-24(16-26(25)38-13-11-35-2)29-17-30-27(22)21-9-4-18(14-23(21)28)31-39(32,33)20-7-5-19(36-3)6-8-20/h4-9,14-17,31H,10-13H2,1-3H3 ZKBJGPDYKGYEHO-UHFFFAOYSA-N 368998 N-[4-[6,7-bis(2- methoxyethoxy)quinazolin-4-yl]-3- fluoro-phenyl]-4-methoxy- benzenesulfonamide::US10227357, Compound P-0262 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368998 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368998&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114309 402365796 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729097 COCCOc1cc2ncnc(-c3ccc(NS(=O)(=O)c4ccc(OC)cc4)cc3F)c2cc1OCCOC InChI=1S/C27H28FN3O7S/c1-34-10-12-37-25-15-22-24(16-26(25)38-13-11-35-2)29-17-30-27(22)21-9-4-18(14-23(21)28)31-39(32,33)20-7-5-19(36-3)6-8-20/h4-9,14-17,31H,10-13H2,1-3H3 ZKBJGPDYKGYEHO-UHFFFAOYSA-N 368998 N-[4-[6,7-bis(2- methoxyethoxy)quinazolin-4-yl]-3- fluoro-phenyl]-4-methoxy- benzenesulfonamide::US10227357, Compound P-0262 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368998 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368998&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114309 402365796 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729098 COCCOc1cc2ncnc(-c3ccc(NS(=O)(=O)C4CC4)cc3F)c2cc1OCCOC InChI=1S/C23H26FN3O6S/c1-30-7-9-32-21-12-18-20(13-22(21)33-10-8-31-2)25-14-26-23(18)17-6-3-15(11-19(17)24)27-34(28,29)16-4-5-16/h3,6,11-14,16,27H,4-5,7-10H2,1-2H3 YSGPBAOLVZQBDU-UHFFFAOYSA-N 368999 N-[4-[6,7-bis(2- methoxyethoxy)quinazolin-4-yl]-3- fluoro- phenyl]cyclopropanesulfonamide::US10227357, Compound P-0263 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368999 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368999&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114768 402365797 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729099 COCCOc1cc2ncnc(-c3ccc(NS(=O)(=O)C4CC4)cc3F)c2cc1OCCOC InChI=1S/C23H26FN3O6S/c1-30-7-9-32-21-12-18-20(13-22(21)33-10-8-31-2)25-14-26-23(18)17-6-3-15(11-19(17)24)27-34(28,29)16-4-5-16/h3,6,11-14,16,27H,4-5,7-10H2,1-2H3 YSGPBAOLVZQBDU-UHFFFAOYSA-N 368999 N-[4-[6,7-bis(2- methoxyethoxy)quinazolin-4-yl]-3- fluoro- phenyl]cyclopropanesulfonamide::US10227357, Compound P-0263 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=368999 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=368999&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114768 402365797 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729100 COCCOc1cc2ncnc(-c3ccc(NS(C)(=O)=O)cc3F)c2cc1OCCOC InChI=1S/C21H24FN3O6S/c1-28-6-8-30-19-11-16-18(12-20(19)31-9-7-29-2)23-13-24-21(16)15-5-4-14(10-17(15)22)25-32(3,26)27/h4-5,10-13,25H,6-9H2,1-3H3 VRYBKTIGZDZKEG-UHFFFAOYSA-N 369000 N-[4-[6,7-bis(2- methoxyethoxy)quinazolin-4-yl]-3- fluoro-phenyl]methanesulfonamide::US10227357, Compound P-0264 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369000 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369000&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114017 402365798 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729101 COCCOc1cc2ncnc(-c3ccc(NS(C)(=O)=O)cc3F)c2cc1OCCOC InChI=1S/C21H24FN3O6S/c1-28-6-8-30-19-11-16-18(12-20(19)31-9-7-29-2)23-13-24-21(16)15-5-4-14(10-17(15)22)25-32(3,26)27/h4-5,10-13,25H,6-9H2,1-3H3 VRYBKTIGZDZKEG-UHFFFAOYSA-N 369000 N-[4-[6,7-bis(2- methoxyethoxy)quinazolin-4-yl]-3- fluoro-phenyl]methanesulfonamide::US10227357, Compound P-0264 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369000 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369000&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114017 402365798 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729102 Fc1cc(NS(=O)(=O)C2CC2)ccc1-c1ncnc2cc3OCCOc3cc12 InChI=1S/C19H16FN3O4S/c20-15-7-11(23-28(24,25)12-2-3-12)1-4-13(15)19-14-8-17-18(27-6-5-26-17)9-16(14)21-10-22-19/h1,4,7-10,12,23H,2-3,5-6H2 ARBMXDHTWRPVOZ-UHFFFAOYSA-N 369001 N-[4-(7,8-dihydro-[1,4]dioxino[2,3- g]quinazolin-4-yl)-3-fluoro- phenyl]cyclopropanesulfonamide::US10227357, Compound P-0265 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369001 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369001&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 89993977 402365799 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729103 Fc1cc(NS(=O)(=O)C2CC2)ccc1-c1ncnc2cc3OCCOc3cc12 InChI=1S/C19H16FN3O4S/c20-15-7-11(23-28(24,25)12-2-3-12)1-4-13(15)19-14-8-17-18(27-6-5-26-17)9-16(14)21-10-22-19/h1,4,7-10,12,23H,2-3,5-6H2 ARBMXDHTWRPVOZ-UHFFFAOYSA-N 369001 N-[4-(7,8-dihydro-[1,4]dioxino[2,3- g]quinazolin-4-yl)-3-fluoro- phenyl]cyclopropanesulfonamide::US10227357, Compound P-0265 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369001 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369001&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 89993977 402365799 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729104 CS(=O)(=O)Nc1ccc(c(F)c1)-c1ncnc2cc3OCCOc3cc12 InChI=1S/C17H14FN3O4S/c1-26(22,23)21-10-2-3-11(13(18)6-10)17-12-7-15-16(25-5-4-24-15)8-14(12)19-9-20-17/h2-3,6-9,21H,4-5H2,1H3 SEOCNZGNNKWAAA-UHFFFAOYSA-N 369002 N-[4-(7,8-dihydro-[1,4]dioxino[2,3- g]quinazolin-4-yl)-3-fluoro- phenyl]methanesulfonamide::US10227357, Compound P-0266 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369002 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369002&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114911 402365800 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729105 CS(=O)(=O)Nc1ccc(c(F)c1)-c1ncnc2cc3OCCOc3cc12 InChI=1S/C17H14FN3O4S/c1-26(22,23)21-10-2-3-11(13(18)6-10)17-12-7-15-16(25-5-4-24-15)8-14(12)19-9-20-17/h2-3,6-9,21H,4-5H2,1H3 SEOCNZGNNKWAAA-UHFFFAOYSA-N 369002 N-[4-(7,8-dihydro-[1,4]dioxino[2,3- g]quinazolin-4-yl)-3-fluoro- phenyl]methanesulfonamide::US10227357, Compound P-0266 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369002 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369002&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114911 402365800 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729106 COc1cc2ncnc(-c3ccc(N)cc3F)c2cc1OC InChI=1S/C16H14FN3O2/c1-21-14-6-11-13(7-15(14)22-2)19-8-20-16(11)10-4-3-9(18)5-12(10)17/h3-8H,18H2,1-2H3 XRKHYWWERZPZCU-UHFFFAOYSA-N 369003 4-(6,7-dimethoxyquinazolin-4-yl)-3- fluoro-aniline::US10227357, Compound P-0267 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369003 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369003&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 89993976 402365801 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729107 COc1cc2ncnc(-c3ccc(N)cc3F)c2cc1OC InChI=1S/C16H14FN3O2/c1-21-14-6-11-13(7-15(14)22-2)19-8-20-16(11)10-4-3-9(18)5-12(10)17/h3-8H,18H2,1-2H3 XRKHYWWERZPZCU-UHFFFAOYSA-N 369003 4-(6,7-dimethoxyquinazolin-4-yl)-3- fluoro-aniline::US10227357, Compound P-0267 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369003 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369003&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 89993976 402365801 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729108 COc1cc2ncnc(-c3ccc(NS(=O)(=O)c4ccc(Cl)cc4)cc3F)c2cc1OC InChI=1S/C22H17ClFN3O4S/c1-30-20-10-17-19(11-21(20)31-2)25-12-26-22(17)16-8-5-14(9-18(16)24)27-32(28,29)15-6-3-13(23)4-7-15/h3-12,27H,1-2H3 MHFAGHOFGRKLCP-UHFFFAOYSA-N 369004 4-chloro-N-[4-(6,7- dimethoxyquinazolin-4-yl)-3-fluoro- phenyl]benzenesulfonamide::US10227357, Compound P-0268 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369004 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369004&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115409 402365802 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729109 COc1cc2ncnc(-c3ccc(NS(=O)(=O)c4ccc(Cl)cc4)cc3F)c2cc1OC InChI=1S/C22H17ClFN3O4S/c1-30-20-10-17-19(11-21(20)31-2)25-12-26-22(17)16-8-5-14(9-18(16)24)27-32(28,29)15-6-3-13(23)4-7-15/h3-12,27H,1-2H3 MHFAGHOFGRKLCP-UHFFFAOYSA-N 369004 4-chloro-N-[4-(6,7- dimethoxyquinazolin-4-yl)-3-fluoro- phenyl]benzenesulfonamide::US10227357, Compound P-0268 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369004 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369004&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115409 402365802 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729110 CCCS(=O)(=O)Nc1ccc(c(F)c1)-c1ncnc2cc(OC)c(OC)cc12 InChI=1S/C19H20FN3O4S/c1-4-7-28(24,25)23-12-5-6-13(15(20)8-12)19-14-9-17(26-2)18(27-3)10-16(14)21-11-22-19/h5-6,8-11,23H,4,7H2,1-3H3 YOVZTTDVJITZNA-UHFFFAOYSA-N 369005 N-[4-(6,7-dimethoxyquinazolin-4-yl)-3- fluoro-phenyl]propane-1-sulfonamide::US10227357, Compound P-0269 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369005 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369005&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114955 402365803 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729111 CCCS(=O)(=O)Nc1ccc(c(F)c1)-c1ncnc2cc(OC)c(OC)cc12 InChI=1S/C19H20FN3O4S/c1-4-7-28(24,25)23-12-5-6-13(15(20)8-12)19-14-9-17(26-2)18(27-3)10-16(14)21-11-22-19/h5-6,8-11,23H,4,7H2,1-3H3 YOVZTTDVJITZNA-UHFFFAOYSA-N 369005 N-[4-(6,7-dimethoxyquinazolin-4-yl)-3- fluoro-phenyl]propane-1-sulfonamide::US10227357, Compound P-0269 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369005 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369005&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114955 402365803 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729112 COc1cc2ncnc(-c3ccc(NS(=O)(=O)C4CC4)cc3F)c2cc1OC InChI=1S/C19H18FN3O4S/c1-26-17-8-14-16(9-18(17)27-2)21-10-22-19(14)13-6-3-11(7-15(13)20)23-28(24,25)12-4-5-12/h3,6-10,12,23H,4-5H2,1-2H3 QQEJWUMFRFHFAG-UHFFFAOYSA-N 369006 N-[4-(6,7-dimethoxyquinazolin-4-yl)-3- fluoro- phenyl]cyclopropanesulfonamide::US10227357, Compound P-0270 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369006 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369006&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114720 402365804 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729113 COc1cc2ncnc(-c3ccc(NS(=O)(=O)C4CC4)cc3F)c2cc1OC InChI=1S/C19H18FN3O4S/c1-26-17-8-14-16(9-18(17)27-2)21-10-22-19(14)13-6-3-11(7-15(13)20)23-28(24,25)12-4-5-12/h3,6-10,12,23H,4-5H2,1-2H3 QQEJWUMFRFHFAG-UHFFFAOYSA-N 369006 N-[4-(6,7-dimethoxyquinazolin-4-yl)-3- fluoro- phenyl]cyclopropanesulfonamide::US10227357, Compound P-0270 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369006 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369006&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114720 402365804 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729114 COc1cc2ncnc(-c3ccc(NS(C)(=O)=O)cc3F)c2cc1OC InChI=1S/C17H16FN3O4S/c1-24-15-7-12-14(8-16(15)25-2)19-9-20-17(12)11-5-4-10(6-13(11)18)21-26(3,22)23/h4-9,21H,1-3H3 MVIGOUSJWQPEPI-UHFFFAOYSA-N 369007 N-[4-(6,7-dimethoxyquinazolin-4-yl)-3- fluoro-phenyl]methanesulfonamide::US10227357, Compound P-0271 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369007 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369007&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115339 402365805 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729115 COc1cc2ncnc(-c3ccc(NS(C)(=O)=O)cc3F)c2cc1OC InChI=1S/C17H16FN3O4S/c1-24-15-7-12-14(8-16(15)25-2)19-9-20-17(12)11-5-4-10(6-13(11)18)21-26(3,22)23/h4-9,21H,1-3H3 MVIGOUSJWQPEPI-UHFFFAOYSA-N 369007 N-[4-(6,7-dimethoxyquinazolin-4-yl)-3- fluoro-phenyl]methanesulfonamide::US10227357, Compound P-0271 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369007 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369007&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115339 402365805 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729116 COc1cc2ncnc(-c3ccc(NS(C)(=O)=O)c(F)c3)c2cc1OC InChI=1S/C17H16FN3O4S/c1-24-15-7-11-14(8-16(15)25-2)19-9-20-17(11)10-4-5-13(12(18)6-10)21-26(3,22)23/h4-9,21H,1-3H3 FTVFFSPBBKJVDE-UHFFFAOYSA-N 369008 N-[4-(6,7-dimethoxyquinazolin-4-yl)-2- fluoro-phenyl]methanesulfonamide::US10227357, Compound P-0272 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369008 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369008&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114701 402365806 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729117 COc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1F)-c1ncnc2cc(OC)c(OC)cc12 InChI=1S/C23H20FN3O5S/c1-30-15-5-7-16(8-6-15)33(28,29)27-19-9-4-14(10-18(19)24)23-17-11-21(31-2)22(32-3)12-20(17)25-13-26-23/h4-13,27H,1-3H3 JDMJXCTWASLKHU-UHFFFAOYSA-N 369009 N-[4-(6,7-dimethoxyquinazolin-4-yl)-2- fluoro-phenyl]-4-methoxy- benzenesulfonamide::US10227357, Compound P-0273 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369009 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369009&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114237 402365807 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729118 COc1cc2ncnc(-c3ccc(NS(=O)(=O)N4CCCC4)c(F)c3)c2cc1OC InChI=1S/C20H21FN4O4S/c1-28-18-10-14-17(11-19(18)29-2)22-12-23-20(14)13-5-6-16(15(21)9-13)24-30(26,27)25-7-3-4-8-25/h5-6,9-12,24H,3-4,7-8H2,1-2H3 DPIKNBZNNNXNKQ-UHFFFAOYSA-N 369010 N-[4-(6,7-dimethoxyquinazolin-4-yl)-2- fluoro-phenyl]pyrrolidine-1- sulfonamide::US10227357, Compound P-0274 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369010 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369010&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115353 402365808 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729119 CCCS(=O)(=O)Nc1ccc(cc1F)-c1ncnc2cc(OC)c(OC)cc12 InChI=1S/C19H20FN3O4S/c1-4-7-28(24,25)23-15-6-5-12(8-14(15)20)19-13-9-17(26-2)18(27-3)10-16(13)21-11-22-19/h5-6,8-11,23H,4,7H2,1-3H3 MLGOLQGSMXGGSK-UHFFFAOYSA-N 369011 N-[4-(6,7-dimethoxyquinazolin-4-yl)-2- fluoro-phenyl]propane-1-sulfonamide::US10227357, Compound P-0275 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369011 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369011&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115359 402365809 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729120 COc1cc2ncnc(-c3ccc(N)c(F)c3)c2cc1OC InChI=1S/C16H14FN3O2/c1-21-14-6-10-13(7-15(14)22-2)19-8-20-16(10)9-3-4-12(18)11(17)5-9/h3-8H,18H2,1-2H3 YZUIFCXTKAAVDS-UHFFFAOYSA-N 369012 4-(6,7-dimethoxyquinazolin-4-yl)-2- fluoro-aniline::US10227357, Compound P-0276 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369012 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369012&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90001680 402365810 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729121 COc1cc2ncnc(-c3ccc(cc3)S(=O)(=O)NC3CC3)c2cc1OC InChI=1S/C19H19N3O4S/c1-25-17-9-15-16(10-18(17)26-2)20-11-21-19(15)12-3-7-14(8-4-12)27(23,24)22-13-5-6-13/h3-4,7-11,13,22H,5-6H2,1-2H3 MXLKLOCAVRBVPN-UHFFFAOYSA-N 369013 N-cyclopropyl-4-(6,7- dimethoxyquinazolin-4- yl)benzenesulfonamide::US10227357, Compound P-0277 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369013 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369013&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90001230 402365811 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729122 COc1cc2ncnc(-c3ccc(cc3)S(N)(=O)=O)c2cc1OC InChI=1S/C16H15N3O4S/c1-22-14-7-12-13(8-15(14)23-2)18-9-19-16(12)10-3-5-11(6-4-10)24(17,20)21/h3-9H,1-2H3,(H2,17,20,21) WJXYRWOBHYQQMD-UHFFFAOYSA-N 369014 4-(6,7-dimethoxyquinazolin-4- yl)benzenesulfonamide::US10227357, Compound P-0278 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369014 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369014&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114975 402365812 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729123 COc1cc2ncnc(-c3cccc(NS(=O)(=O)C4CC4)c3)c2cc1OC InChI=1S/C19H19N3O4S/c1-25-17-9-15-16(10-18(17)26-2)20-11-21-19(15)12-4-3-5-13(8-12)22-27(23,24)14-6-7-14/h3-5,8-11,14,22H,6-7H2,1-2H3 WXIPRVRNALBTEJ-UHFFFAOYSA-N 369015 N-[3-(6,7-dimethoxyquinazolin-4- yl)phenyl]cyclopropanesulfonamide::US10227357, Compound P-0279 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369015 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369015&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90001178 402365813 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729124 COc1cc2ncnc(-c3ccc(NS(=O)(=O)C4CC4)cc3)c2cc1OC InChI=1S/C19H19N3O4S/c1-25-17-9-15-16(10-18(17)26-2)20-11-21-19(15)12-3-5-13(6-4-12)22-27(23,24)14-7-8-14/h3-6,9-11,14,22H,7-8H2,1-2H3 XUFRTYOSZPCYPH-UHFFFAOYSA-N 369016 N-[4-(6,7-dimethoxyquinazolin-4- yl)phenyl]cyclopropanesulfonamide::US10227357, Compound P-0280 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369016 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369016&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90000899 402365814 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729125 Cc1ccc(cn1)-c1cc2c(ncnc2[nH]1)C1=CCC(CC1)NS(=O)(=O)c1ccc(OC(F)(F)F)cc1 369017 N-[4-[6-(6-methyl-3-pyridyl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]cyclohex-3- en-1-yl]-4- (trifluoromethoxy)benzenesulfonamide::US10227357, Compound P-0281::US10227357, Compound P-0544 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369017&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114519 402365815 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729126 Cc1ccc(cn1)-c1cc2c(ncnc2[nH]1)C1=CCC(CC1)NS(=O)(=O)c1ccc(OC(F)(F)F)cc1 369017 N-[4-[6-(6-methyl-3-pyridyl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]cyclohex-3- en-1-yl]-4- (trifluoromethoxy)benzenesulfonamide::US10227357, Compound P-0281::US10227357, Compound P-0544 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369017&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114519 402365815 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729127 CCCc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)-c1ncnc2[nH]c(C)cc12 InChI=1S/C22H22N4O2S/c1-3-4-16-5-11-19(12-6-16)29(27,28)26-18-9-7-17(8-10-18)21-20-13-15(2)25-22(20)24-14-23-21/h5-14,26H,3-4H2,1-2H3,(H,23,24,25) OXBIXKJYXSFAGZ-UHFFFAOYSA-N 369018 N-[4-(6-methyl-7H-pyrrolo[2,3- d]pyrimidin-4-yl)phenyl]-4-propyl- benzenesulfonamide::US10227357, Compound P-0282 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369018 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369018&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114579 402365816 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729128 CCCc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)-c1ncnc2[nH]c(C)cc12 InChI=1S/C22H22N4O2S/c1-3-4-16-5-11-19(12-6-16)29(27,28)26-18-9-7-17(8-10-18)21-20-13-15(2)25-22(20)24-14-23-21/h5-14,26H,3-4H2,1-2H3,(H,23,24,25) OXBIXKJYXSFAGZ-UHFFFAOYSA-N 369018 N-[4-(6-methyl-7H-pyrrolo[2,3- d]pyrimidin-4-yl)phenyl]-4-propyl- benzenesulfonamide::US10227357, Compound P-0282 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369018 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369018&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114579 402365816 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729129 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2cccc(C)c2)cc1 InChI=1S/C20H18N4O2S/c1-13-4-3-5-17(10-13)27(25,26)24-16-8-6-15(7-9-16)19-18-11-14(2)23-20(18)22-12-21-19/h3-12,24H,1-2H3,(H,21,22,23) GLWGENGPVSCOHS-UHFFFAOYSA-N 369019 3-methyl-N-[4-(6-methyl-7H-pyrrolo[2,3- d]pyrimidin-4- yl)phenyl]benzenesulfonamide::US10227357, Compound P-0283 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369019 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369019&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115081 402365817 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729130 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2cccc(C)c2)cc1 InChI=1S/C20H18N4O2S/c1-13-4-3-5-17(10-13)27(25,26)24-16-8-6-15(7-9-16)19-18-11-14(2)23-20(18)22-12-21-19/h3-12,24H,1-2H3,(H,21,22,23) GLWGENGPVSCOHS-UHFFFAOYSA-N 369019 3-methyl-N-[4-(6-methyl-7H-pyrrolo[2,3- d]pyrimidin-4- yl)phenyl]benzenesulfonamide::US10227357, Compound P-0283 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369019 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369019&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115081 402365817 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729131 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2cccc(OC(F)(F)F)c2)cc1 InChI=1S/C20H15F3N4O3S/c1-12-9-17-18(24-11-25-19(17)26-12)13-5-7-14(8-6-13)27-31(28,29)16-4-2-3-15(10-16)30-20(21,22)23/h2-11,27H,1H3,(H,24,25,26) IFVRKCSQWBOVKT-UHFFFAOYSA-N 369020 N-[4-(6-methyl-7H-pyrrolo[2,3- d]pyrimidin-4-yl)phenyl]-3- (trifluoromethoxy)benzenesulfonamide::US10227357, Compound P-0284 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369020 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369020&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114568 402365818 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729132 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2cccc(OC(F)(F)F)c2)cc1 InChI=1S/C20H15F3N4O3S/c1-12-9-17-18(24-11-25-19(17)26-12)13-5-7-14(8-6-13)27-31(28,29)16-4-2-3-15(10-16)30-20(21,22)23/h2-11,27H,1H3,(H,24,25,26) IFVRKCSQWBOVKT-UHFFFAOYSA-N 369020 N-[4-(6-methyl-7H-pyrrolo[2,3- d]pyrimidin-4-yl)phenyl]-3- (trifluoromethoxy)benzenesulfonamide::US10227357, Compound P-0284 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369020 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369020&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114568 402365818 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729133 Cn1cc(cn1)-c1cc2c(ncnc2[nH]1)C1=CCC(CC1)NS(=O)(=O)c1ccc(OC(F)(F)F)cc1 369021 N-[4-[6-(1-methylpyrazol-4-yl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]cyclohex-3- en-1-yl]-4- (trifluoromethoxy)benzenesulfonamide::US10227357, Compound P-0285::US10227357, Compound P-0545 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369021 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369021&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115480 402365819 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729134 Cn1cc(cn1)-c1cc2c(ncnc2[nH]1)C1=CCC(CC1)NS(=O)(=O)c1ccc(OC(F)(F)F)cc1 369021 N-[4-[6-(1-methylpyrazol-4-yl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]cyclohex-3- en-1-yl]-4- (trifluoromethoxy)benzenesulfonamide::US10227357, Compound P-0285::US10227357, Compound P-0545 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369021 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369021&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115480 402365819 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729135 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2ccc(C)nc2)cc1F InChI=1S/C19H16FN5O2S/c1-11-3-5-14(9-21-11)28(26,27)25-13-4-6-15(17(20)8-13)18-16-7-12(2)24-19(16)23-10-22-18/h3-10,25H,1-2H3,(H,22,23,24) VFWZTGONPHMZRV-UHFFFAOYSA-N 369022 N-[3-fluoro-4-(6-methyl-7H-pyrrolo[2,3- d]pyrimidin-4-yl)phenyl]-6-methyl- pyridine-3-sulfonamide::US10227357, Compound P-0286 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369022 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369022&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114400 402365820 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729136 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2ccc(C)nc2)cc1F InChI=1S/C19H16FN5O2S/c1-11-3-5-14(9-21-11)28(26,27)25-13-4-6-15(17(20)8-13)18-16-7-12(2)24-19(16)23-10-22-18/h3-10,25H,1-2H3,(H,22,23,24) VFWZTGONPHMZRV-UHFFFAOYSA-N 369022 N-[3-fluoro-4-(6-methyl-7H-pyrrolo[2,3- d]pyrimidin-4-yl)phenyl]-6-methyl- pyridine-3-sulfonamide::US10227357, Compound P-0286 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369022 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369022&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114400 402365820 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729137 CCCCc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)-c1ncnc2[nH]c(C)cc12 InChI=1S/C23H24N4O2S/c1-3-4-5-17-6-12-20(13-7-17)30(28,29)27-19-10-8-18(9-11-19)22-21-14-16(2)26-23(21)25-15-24-22/h6-15,27H,3-5H2,1-2H3,(H,24,25,26) HPYCVAHGXZYKHY-UHFFFAOYSA-N 369023 4-butyl-N-[4-(6-methyl-7H-pyrrolo[2,3- d]pyrimidin-4- yl)phenyl]benzenesulfonamide::US10227357, Compound P-0287 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369023 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369023&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114815 402365821 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729138 CCCCc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)-c1ncnc2[nH]c(C)cc12 InChI=1S/C23H24N4O2S/c1-3-4-5-17-6-12-20(13-7-17)30(28,29)27-19-10-8-18(9-11-19)22-21-14-16(2)26-23(21)25-15-24-22/h6-15,27H,3-5H2,1-2H3,(H,24,25,26) HPYCVAHGXZYKHY-UHFFFAOYSA-N 369023 4-butyl-N-[4-(6-methyl-7H-pyrrolo[2,3- d]pyrimidin-4- yl)phenyl]benzenesulfonamide::US10227357, Compound P-0287 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369023 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369023&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114815 402365821 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729139 CCCCS(=O)(=O)Nc1ccc(cc1)-c1ncnc2[nH]c(C)cc12 InChI=1S/C17H20N4O2S/c1-3-4-9-24(22,23)21-14-7-5-13(6-8-14)16-15-10-12(2)20-17(15)19-11-18-16/h5-8,10-11,21H,3-4,9H2,1-2H3,(H,18,19,20) ZSLWJPMDKQKYET-UHFFFAOYSA-N 369024 N-[4-(6-methyl-7H-pyrrolo[2,3- d]pyrimidin-4-yl)phenyl]butane-1- sulfonamide::US10227357, Compound P-0288 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369024 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369024&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114937 402365822 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729140 CCCCS(=O)(=O)Nc1ccc(cc1)-c1ncnc2[nH]c(C)cc12 InChI=1S/C17H20N4O2S/c1-3-4-9-24(22,23)21-14-7-5-13(6-8-14)16-15-10-12(2)20-17(15)19-11-18-16/h5-8,10-11,21H,3-4,9H2,1-2H3,(H,18,19,20) ZSLWJPMDKQKYET-UHFFFAOYSA-N 369024 N-[4-(6-methyl-7H-pyrrolo[2,3- d]pyrimidin-4-yl)phenyl]butane-1- sulfonamide::US10227357, Compound P-0288 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369024 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369024&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114937 402365822 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729141 CCCS(=O)(=O)Nc1ccc(cc1)-c1ncnc2[nH]c(C)cc12 InChI=1S/C16H18N4O2S/c1-3-8-23(21,22)20-13-6-4-12(5-7-13)15-14-9-11(2)19-16(14)18-10-17-15/h4-7,9-10,20H,3,8H2,1-2H3,(H,17,18,19) XFXGQADTTOTEGX-UHFFFAOYSA-N 369025 N-[4-(6-methyl-7H-pyrrolo[2,3- d]pyrimidin-4-yl)phenyl]propane-1- sulfonamide::US10227357, Compound P-0289 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369025 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369025&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115201 402365823 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729142 CCCS(=O)(=O)Nc1ccc(cc1)-c1ncnc2[nH]c(C)cc12 InChI=1S/C16H18N4O2S/c1-3-8-23(21,22)20-13-6-4-12(5-7-13)15-14-9-11(2)19-16(14)18-10-17-15/h4-7,9-10,20H,3,8H2,1-2H3,(H,17,18,19) XFXGQADTTOTEGX-UHFFFAOYSA-N 369025 N-[4-(6-methyl-7H-pyrrolo[2,3- d]pyrimidin-4-yl)phenyl]propane-1- sulfonamide::US10227357, Compound P-0289 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369025 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369025&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115201 402365823 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729143 Fc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)-c1ncnc2[nH]c(cc12)C1CCCC1 InChI=1S/C23H21FN4O2S/c24-17-7-11-19(12-8-17)31(29,30)28-18-9-5-16(6-10-18)22-20-13-21(15-3-1-2-4-15)27-23(20)26-14-25-22/h5-15,28H,1-4H2,(H,25,26,27) FLQPLQYEIXTAHY-UHFFFAOYSA-N 369026 N-[4-(6-cyclopentyl-7H-pyrrolo[2,3- d]pyrimidin-4-yl)phenyl]-4-fluoro- benzenesulfonamide::US10227357, Compound P-0290 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369026 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369026&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114650 402365824 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729144 Fc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)-c1ncnc2[nH]c(cc12)C1CCCC1 InChI=1S/C23H21FN4O2S/c24-17-7-11-19(12-8-17)31(29,30)28-18-9-5-16(6-10-18)22-20-13-21(15-3-1-2-4-15)27-23(20)26-14-25-22/h5-15,28H,1-4H2,(H,25,26,27) FLQPLQYEIXTAHY-UHFFFAOYSA-N 369026 N-[4-(6-cyclopentyl-7H-pyrrolo[2,3- d]pyrimidin-4-yl)phenyl]-4-fluoro- benzenesulfonamide::US10227357, Compound P-0290 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369026 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369026&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114650 402365824 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729145 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2ccc(C)s2)cc1F InChI=1S/C18H15FN4O2S2/c1-10-7-14-17(20-9-21-18(14)22-10)13-5-4-12(8-15(13)19)23-27(24,25)16-6-3-11(2)26-16/h3-9,23H,1-2H3,(H,20,21,22) MUXZVUIAYYWUPG-UHFFFAOYSA-N 369027 N-[3-fluoro-4-(6-methyl-7H-pyrrolo[2,3- d]pyrimidin-4-yl)phenyl]-5-methyl- thiophene-2-sulfonamide::US10227357, Compound P-0291 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369027 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369027&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115437 402365825 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729146 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2ccc(C)s2)cc1F InChI=1S/C18H15FN4O2S2/c1-10-7-14-17(20-9-21-18(14)22-10)13-5-4-12(8-15(13)19)23-27(24,25)16-6-3-11(2)26-16/h3-9,23H,1-2H3,(H,20,21,22) MUXZVUIAYYWUPG-UHFFFAOYSA-N 369027 N-[3-fluoro-4-(6-methyl-7H-pyrrolo[2,3- d]pyrimidin-4-yl)phenyl]-5-methyl- thiophene-2-sulfonamide::US10227357, Compound P-0291 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369027 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369027&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115437 402365825 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729147 CCc1ccc(cc1)S(=O)(=O)Nc1ccc(c(F)c1)-c1ncnc2[nH]c(C)cc12 InChI=1S/C21H19FN4O2S/c1-3-14-4-7-16(8-5-14)29(27,28)26-15-6-9-17(19(22)11-15)20-18-10-13(2)25-21(18)24-12-23-20/h4-12,26H,3H2,1-2H3,(H,23,24,25) YLWDWMKLEALYEP-UHFFFAOYSA-N 369028 4-ethyl-N-[3-fluoro-4-(6-methyl-7H- pyrrolo[2,3-d]pyrimidin-4- yl)phenyl]benzenesulfonamide::US10227357, Compound P-0292 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369028 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369028&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114257 402365826 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729148 CCc1ccc(cc1)S(=O)(=O)Nc1ccc(c(F)c1)-c1ncnc2[nH]c(C)cc12 InChI=1S/C21H19FN4O2S/c1-3-14-4-7-16(8-5-14)29(27,28)26-15-6-9-17(19(22)11-15)20-18-10-13(2)25-21(18)24-12-23-20/h4-12,26H,3H2,1-2H3,(H,23,24,25) YLWDWMKLEALYEP-UHFFFAOYSA-N 369028 4-ethyl-N-[3-fluoro-4-(6-methyl-7H- pyrrolo[2,3-d]pyrimidin-4- yl)phenyl]benzenesulfonamide::US10227357, Compound P-0292 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369028 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369028&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114257 402365826 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729149 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2ccc(C)cc2)cc1F InChI=1S/C20H17FN4O2S/c1-12-3-6-15(7-4-12)28(26,27)25-14-5-8-16(18(21)10-14)19-17-9-13(2)24-20(17)23-11-22-19/h3-11,25H,1-2H3,(H,22,23,24) JITNPLFMFATIKU-UHFFFAOYSA-N 369029 N-[3-fluoro-4-(6-methyl-7H-pyrrolo[2,3- d]pyrimidin-4-yl)phenyl]-4-methyl- benzenesulfonamide::US10227357, Compound P-0293 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369029 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369029&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114318 402365827 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729150 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2ccc(C)cc2)cc1F InChI=1S/C20H17FN4O2S/c1-12-3-6-15(7-4-12)28(26,27)25-14-5-8-16(18(21)10-14)19-17-9-13(2)24-20(17)23-11-22-19/h3-11,25H,1-2H3,(H,22,23,24) JITNPLFMFATIKU-UHFFFAOYSA-N 369029 N-[3-fluoro-4-(6-methyl-7H-pyrrolo[2,3- d]pyrimidin-4-yl)phenyl]-4-methyl- benzenesulfonamide::US10227357, Compound P-0293 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369029 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369029&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114318 402365827 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729151 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2ccc3OCOc3c2)cc1 InChI=1S/C20H16N4O4S/c1-12-8-16-19(21-10-22-20(16)23-12)13-2-4-14(5-3-13)24-29(25,26)15-6-7-17-18(9-15)28-11-27-17/h2-10,24H,11H2,1H3,(H,21,22,23) OSOXVTLOOXQSEI-UHFFFAOYSA-N 369030 N-[4-(6-methyl-7H-pyrrolo[2,3- d]pyrimidin-4-yl)phenyl]-1,3- benzodioxole-5-sulfonamide::US10227357, Compound P-0294 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369030 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369030&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115291 402365828 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729152 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2ccc3OCOc3c2)cc1 InChI=1S/C20H16N4O4S/c1-12-8-16-19(21-10-22-20(16)23-12)13-2-4-14(5-3-13)24-29(25,26)15-6-7-17-18(9-15)28-11-27-17/h2-10,24H,11H2,1H3,(H,21,22,23) OSOXVTLOOXQSEI-UHFFFAOYSA-N 369030 N-[4-(6-methyl-7H-pyrrolo[2,3- d]pyrimidin-4-yl)phenyl]-1,3- benzodioxole-5-sulfonamide::US10227357, Compound P-0294 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369030 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369030&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115291 402365828 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729153 CC1(C)CC(=CC(C)(C)N1)c1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2ccc(F)cc2)cc1 InChI=1S/C27H28FN5O2S/c1-26(2)14-18(15-27(3,4)33-26)23-13-22-24(29-16-30-25(22)31-23)17-5-9-20(10-6-17)32-36(34,35)21-11-7-19(28)8-12-21/h5-14,16,32-33H,15H2,1-4H3,(H,29,30,31) XZUFMKVARKYYFF-UHFFFAOYSA-N 369031 4-fluoro-N-[4-[6-(2,2,6,6-tetramethyl- 1,3-dihydropyridin-4-yl)-7H-pyrrolo[2,3- d]pyrimidin-4- yl]phenyl]benzenesulfonamide::US10227357, Compound P-0295 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369031 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369031&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114667 402365829 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729154 CC1(C)CC(=CC(C)(C)N1)c1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2ccc(F)cc2)cc1 InChI=1S/C27H28FN5O2S/c1-26(2)14-18(15-27(3,4)33-26)23-13-22-24(29-16-30-25(22)31-23)17-5-9-20(10-6-17)32-36(34,35)21-11-7-19(28)8-12-21/h5-14,16,32-33H,15H2,1-4H3,(H,29,30,31) XZUFMKVARKYYFF-UHFFFAOYSA-N 369031 4-fluoro-N-[4-[6-(2,2,6,6-tetramethyl- 1,3-dihydropyridin-4-yl)-7H-pyrrolo[2,3- d]pyrimidin-4- yl]phenyl]benzenesulfonamide::US10227357, Compound P-0295 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369031 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369031&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114667 402365829 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729155 Fc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)-c1ncnc2[nH]c(cc12)C1=CCCC1 InChI=1S/C23H19FN4O2S/c24-17-7-11-19(12-8-17)31(29,30)28-18-9-5-16(6-10-18)22-20-13-21(15-3-1-2-4-15)27-23(20)26-14-25-22/h3,5-14,28H,1-2,4H2,(H,25,26,27) MXCVXNHHJPBCIY-UHFFFAOYSA-N 369032 N-[4-[6-(cyclopenten-1-yl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]phenyl]-4- fluoro-benzenesulfonamide::US10227357, Compound P-0296 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369032 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369032&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114574 402365830 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729156 Fc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)-c1ncnc2[nH]c(cc12)C1=CCCC1 InChI=1S/C23H19FN4O2S/c24-17-7-11-19(12-8-17)31(29,30)28-18-9-5-16(6-10-18)22-20-13-21(15-3-1-2-4-15)27-23(20)26-14-25-22/h3,5-14,28H,1-2,4H2,(H,25,26,27) MXCVXNHHJPBCIY-UHFFFAOYSA-N 369032 N-[4-[6-(cyclopenten-1-yl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]phenyl]-4- fluoro-benzenesulfonamide::US10227357, Compound P-0296 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369032 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369032&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114574 402365830 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729157 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2ccc(nc2)C(F)(F)F)cc1 InChI=1S/C19H14F3N5O2S/c1-11-8-15-17(24-10-25-18(15)26-11)12-2-4-13(5-3-12)27-30(28,29)14-6-7-16(23-9-14)19(20,21)22/h2-10,27H,1H3,(H,24,25,26) UBCNGZMZJYGSMC-UHFFFAOYSA-N 369033 N-[4-(6-methyl-7H-pyrrolo[2,3- d]pyrimidin-4-yl)phenyl]-6- (trifluoromethyl)pyridine-3-sulfonamide::US10227357, Compound P-0297 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369033 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369033&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114086 402365831 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729158 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2ccc(nc2)C(F)(F)F)cc1 InChI=1S/C19H14F3N5O2S/c1-11-8-15-17(24-10-25-18(15)26-11)12-2-4-13(5-3-12)27-30(28,29)14-6-7-16(23-9-14)19(20,21)22/h2-10,27H,1H3,(H,24,25,26) UBCNGZMZJYGSMC-UHFFFAOYSA-N 369033 N-[4-(6-methyl-7H-pyrrolo[2,3- d]pyrimidin-4-yl)phenyl]-6- (trifluoromethyl)pyridine-3-sulfonamide::US10227357, Compound P-0297 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369033 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369033&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114086 402365831 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729159 CC1(C)CC(=CC(C)(C)O1)c1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2ccc(F)cc2)cc1 InChI=1S/C27H27FN4O3S/c1-26(2)14-18(15-27(3,4)35-26)23-13-22-24(29-16-30-25(22)31-23)17-5-9-20(10-6-17)32-36(33,34)21-11-7-19(28)8-12-21/h5-14,16,32H,15H2,1-4H3,(H,29,30,31) GHBPTZONLMYJLZ-UHFFFAOYSA-N 369034 4-fluoro-N-[4-[6-(2,2,6,6-tetramethyl-3H- pyran-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]phenyl]benzenesulfonamide::US10227357, Compound P-0298 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369034 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369034&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114441 402365832 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729160 CC1(C)CC(=CC(C)(C)O1)c1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2ccc(F)cc2)cc1 InChI=1S/C27H27FN4O3S/c1-26(2)14-18(15-27(3,4)35-26)23-13-22-24(29-16-30-25(22)31-23)17-5-9-20(10-6-17)32-36(33,34)21-11-7-19(28)8-12-21/h5-14,16,32H,15H2,1-4H3,(H,29,30,31) GHBPTZONLMYJLZ-UHFFFAOYSA-N 369034 4-fluoro-N-[4-[6-(2,2,6,6-tetramethyl-3H- pyran-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]phenyl]benzenesulfonamide::US10227357, Compound P-0298 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369034 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369034&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114441 402365832 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729161 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2cc(Cl)c(Cl)s2)cc1 InChI=1S/C17H12Cl2N4O2S2/c1-9-6-12-15(20-8-21-17(12)22-9)10-2-4-11(5-3-10)23-27(24,25)14-7-13(18)16(19)26-14/h2-8,23H,1H3,(H,20,21,22) VJFFDMDXSMMYEI-UHFFFAOYSA-N 369035 4,5-dichloro-N-[4-(6-methyl-7H- pyrrolo[2,3-d]pyrimidin-4- yl)phenyl]thiophene-2-sulfonamide::US10227357, Compound P-0299 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369035 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369035&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114664 402365833 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729162 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2cc(Cl)c(Cl)s2)cc1 InChI=1S/C17H12Cl2N4O2S2/c1-9-6-12-15(20-8-21-17(12)22-9)10-2-4-11(5-3-10)23-27(24,25)14-7-13(18)16(19)26-14/h2-8,23H,1H3,(H,20,21,22) VJFFDMDXSMMYEI-UHFFFAOYSA-N 369035 4,5-dichloro-N-[4-(6-methyl-7H- pyrrolo[2,3-d]pyrimidin-4- yl)phenyl]thiophene-2-sulfonamide::US10227357, Compound P-0299 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369035 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369035&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114664 402365833 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729163 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2sc(C)nc2C)cc1 InChI=1S/C18H17N5O2S2/c1-10-8-15-16(19-9-20-17(15)21-10)13-4-6-14(7-5-13)23-27(24,25)18-11(2)22-12(3)26-18/h4-9,23H,1-3H3,(H,19,20,21) KFANZWMOYATVNK-UHFFFAOYSA-N 369036 2,4-dimethyl-N-[4-(6-methyl-7H- pyrrolo[2,3-d]pyrimidin-4- yl)phenyl]thiazole-5-sulfonamide::US10227357, Compound P-0300 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369036 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369036&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115290 402365834 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729164 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2sc(C)nc2C)cc1 InChI=1S/C18H17N5O2S2/c1-10-8-15-16(19-9-20-17(15)21-10)13-4-6-14(7-5-13)23-27(24,25)18-11(2)22-12(3)26-18/h4-9,23H,1-3H3,(H,19,20,21) KFANZWMOYATVNK-UHFFFAOYSA-N 369036 2,4-dimethyl-N-[4-(6-methyl-7H- pyrrolo[2,3-d]pyrimidin-4- yl)phenyl]thiazole-5-sulfonamide::US10227357, Compound P-0300 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369036 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369036&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115290 402365834 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729165 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2ccc(C)nc2)cc1 InChI=1S/C19H17N5O2S/c1-12-3-8-16(10-20-12)27(25,26)24-15-6-4-14(5-7-15)18-17-9-13(2)23-19(17)22-11-21-18/h3-11,24H,1-2H3,(H,21,22,23) ITWKBHPUHRVRJV-UHFFFAOYSA-N 369037 6-methyl-N-[4-(6-methyl-7H-pyrrolo[2,3- d]pyrimidin-4-yl)phenyl]pyridine-3- sulfonamide::US10227357, Compound P-0301 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369037 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369037&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115009 402365835 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729166 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2ccc(C)nc2)cc1 InChI=1S/C19H17N5O2S/c1-12-3-8-16(10-20-12)27(25,26)24-15-6-4-14(5-7-15)18-17-9-13(2)23-19(17)22-11-21-18/h3-11,24H,1-2H3,(H,21,22,23) ITWKBHPUHRVRJV-UHFFFAOYSA-N 369037 6-methyl-N-[4-(6-methyl-7H-pyrrolo[2,3- d]pyrimidin-4-yl)phenyl]pyridine-3- sulfonamide::US10227357, Compound P-0301 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369037 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369037&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115009 402365835 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729167 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2ccc3CCCc3c2)cc1 InChI=1S/C22H20N4O2S/c1-14-11-20-21(23-13-24-22(20)25-14)16-5-8-18(9-6-16)26-29(27,28)19-10-7-15-3-2-4-17(15)12-19/h5-13,26H,2-4H2,1H3,(H,23,24,25) BLFLSXBNWQWIMR-UHFFFAOYSA-N 369038 N-[4-(6-methyl-7H-pyrrolo[2,3- d]pyrimidin-4-yl)phenyl]indane-5- sulfonamide::US10227357, Compound P-0302 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369038 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369038&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114894 402365836 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729168 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2ccc3CCCc3c2)cc1 InChI=1S/C22H20N4O2S/c1-14-11-20-21(23-13-24-22(20)25-14)16-5-8-18(9-6-16)26-29(27,28)19-10-7-15-3-2-4-17(15)12-19/h5-13,26H,2-4H2,1H3,(H,23,24,25) BLFLSXBNWQWIMR-UHFFFAOYSA-N 369038 N-[4-(6-methyl-7H-pyrrolo[2,3- d]pyrimidin-4-yl)phenyl]indane-5- sulfonamide::US10227357, Compound P-0302 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369038 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369038&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114894 402365836 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729169 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2ccc3oncc3c2)cc1 InChI=1S/C20H15N5O3S/c1-12-8-17-19(21-11-22-20(17)24-12)13-2-4-15(5-3-13)25-29(26,27)16-6-7-18-14(9-16)10-23-28-18/h2-11,25H,1H3,(H,21,22,24) JSLMBIWREXCMOG-UHFFFAOYSA-N 369039 N-[4-(6-methyl-7H-pyrrolo[2,3- d]pyrimidin-4-yl)phenyl]-1,2- benzoxazole-5-sulfonamide::US10227357, Compound P-0303 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369039 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369039&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115415 402365837 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729170 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2ccc3oncc3c2)cc1 InChI=1S/C20H15N5O3S/c1-12-8-17-19(21-11-22-20(17)24-12)13-2-4-15(5-3-13)25-29(26,27)16-6-7-18-14(9-16)10-23-28-18/h2-11,25H,1H3,(H,21,22,24) JSLMBIWREXCMOG-UHFFFAOYSA-N 369039 N-[4-(6-methyl-7H-pyrrolo[2,3- d]pyrimidin-4-yl)phenyl]-1,2- benzoxazole-5-sulfonamide::US10227357, Compound P-0303 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369039 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369039&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115415 402365837 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729171 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2cc(Cl)cs2)cc1 InChI=1S/C17H13ClN4O2S2/c1-10-6-14-16(19-9-20-17(14)21-10)11-2-4-13(5-3-11)22-26(23,24)15-7-12(18)8-25-15/h2-9,22H,1H3,(H,19,20,21) JUYWLYRQKWZJOJ-UHFFFAOYSA-N 369040 4-chloro-N-[4-(6-methyl-7H-pyrrolo[2,3- d]pyrimidin-4-yl)phenyl]thiophene-2- sulfonamide::US10227357, Compound P-0304 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369040 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369040&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114962 402365838 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729172 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2cc(Cl)cs2)cc1 InChI=1S/C17H13ClN4O2S2/c1-10-6-14-16(19-9-20-17(14)21-10)11-2-4-13(5-3-11)22-26(23,24)15-7-12(18)8-25-15/h2-9,22H,1H3,(H,19,20,21) JUYWLYRQKWZJOJ-UHFFFAOYSA-N 369040 4-chloro-N-[4-(6-methyl-7H-pyrrolo[2,3- d]pyrimidin-4-yl)phenyl]thiophene-2- sulfonamide::US10227357, Compound P-0304 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369040 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369040&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114962 402365838 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729173 Cc1csc(c1)S(=O)(=O)Nc1ccc(cc1)-c1ncnc2[nH]c(C)cc12 InChI=1S/C18H16N4O2S2/c1-11-7-16(25-9-11)26(23,24)22-14-5-3-13(4-6-14)17-15-8-12(2)21-18(15)20-10-19-17/h3-10,22H,1-2H3,(H,19,20,21) UIPNZNIASMDZQF-UHFFFAOYSA-N 369041 4-methyl-N-[4-(6-methyl-7H-pyrrolo[2,3- d]pyrimidin-4-yl)phenyl]thiophene-2- sulfonamide::US10227357, Compound P-0305 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369041 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369041&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115121 402365839 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729174 Cc1csc(c1)S(=O)(=O)Nc1ccc(cc1)-c1ncnc2[nH]c(C)cc12 InChI=1S/C18H16N4O2S2/c1-11-7-16(25-9-11)26(23,24)22-14-5-3-13(4-6-14)17-15-8-12(2)21-18(15)20-10-19-17/h3-10,22H,1-2H3,(H,19,20,21) UIPNZNIASMDZQF-UHFFFAOYSA-N 369041 4-methyl-N-[4-(6-methyl-7H-pyrrolo[2,3- d]pyrimidin-4-yl)phenyl]thiophene-2- sulfonamide::US10227357, Compound P-0305 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369041 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369041&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115121 402365839 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729175 CC(C)c1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)-c1ncnc2[nH]c(C)cc12 InChI=1S/C22H22N4O2S/c1-14(2)16-6-10-19(11-7-16)29(27,28)26-18-8-4-17(5-9-18)21-20-12-15(3)25-22(20)24-13-23-21/h4-14,26H,1-3H3,(H,23,24,25) NZSBMQWCGSEWLO-UHFFFAOYSA-N 369042 4-isopropyl-N-[4-(6-methyl-7H- pyrrolo[2,3-d]pyrimidin-4- yl)phenyl]benzenesulfonamide::US10227357, Compound P-0306 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369042 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369042&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114617 402365840 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729176 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2ccc3OCCc3c2)cc1 InChI=1S/C21H18N4O3S/c1-13-10-18-20(22-12-23-21(18)24-13)14-2-4-16(5-3-14)25-29(26,27)17-6-7-19-15(11-17)8-9-28-19/h2-7,10-12,25H,8-9H2,1H3,(H,22,23,24) LXLJLZXDFDCQRO-UHFFFAOYSA-N 369043 N-[4-(6-methyl-7H-pyrrolo[2,3- d]pyrimidin-4-yl)phenyl]-2,3- dihydrobenzofuran-5-sulfonamide::US10227357, Compound P-0307 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369043 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369043&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114854 402365841 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729177 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2ccc3OCCc3c2)cc1 InChI=1S/C21H18N4O3S/c1-13-10-18-20(22-12-23-21(18)24-13)14-2-4-16(5-3-14)25-29(26,27)17-6-7-19-15(11-17)8-9-28-19/h2-7,10-12,25H,8-9H2,1H3,(H,22,23,24) LXLJLZXDFDCQRO-UHFFFAOYSA-N 369043 N-[4-(6-methyl-7H-pyrrolo[2,3- d]pyrimidin-4-yl)phenyl]-2,3- dihydrobenzofuran-5-sulfonamide::US10227357, Compound P-0307 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369043 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369043&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114854 402365841 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729178 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2cc3cc(C)ccc3s2)cc1 InChI=1S/C22H18N4O2S2/c1-13-3-8-19-16(9-13)11-20(29-19)30(27,28)26-17-6-4-15(5-7-17)21-18-10-14(2)25-22(18)24-12-23-21/h3-12,26H,1-2H3,(H,23,24,25) QIXBAQZYLABCIG-UHFFFAOYSA-N 369044 5-methyl-N-[4-(6-methyl-7H-pyrrolo[2,3- d]pyrimidin-4-yl)phenyl]benzothiophene- 2-sulfonamide::US10227357, Compound P-0308 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369044 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369044&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115173 402365842 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729179 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2cc3cc(C)ccc3s2)cc1 InChI=1S/C22H18N4O2S2/c1-13-3-8-19-16(9-13)11-20(29-19)30(27,28)26-17-6-4-15(5-7-17)21-18-10-14(2)25-22(18)24-12-23-21/h3-12,26H,1-2H3,(H,23,24,25) QIXBAQZYLABCIG-UHFFFAOYSA-N 369044 5-methyl-N-[4-(6-methyl-7H-pyrrolo[2,3- d]pyrimidin-4-yl)phenyl]benzothiophene- 2-sulfonamide::US10227357, Compound P-0308 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369044 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369044&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115173 402365842 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729180 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2cc3ccccc3s2)cc1 InChI=1S/C21H16N4O2S2/c1-13-10-17-20(22-12-23-21(17)24-13)14-6-8-16(9-7-14)25-29(26,27)19-11-15-4-2-3-5-18(15)28-19/h2-12,25H,1H3,(H,22,23,24) GBAIBANMGUWWFB-UHFFFAOYSA-N 369045 N-[4-(6-methyl-7H-pyrrolo[2,3- d]pyrimidin-4-yl)phenyl]benzothiophene- 2-sulfonamide::US10227357, Compound P-0309 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369045 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369045&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114543 402365843 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729181 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2cc3ccccc3s2)cc1 InChI=1S/C21H16N4O2S2/c1-13-10-17-20(22-12-23-21(17)24-13)14-6-8-16(9-7-14)25-29(26,27)19-11-15-4-2-3-5-18(15)28-19/h2-12,25H,1H3,(H,22,23,24) GBAIBANMGUWWFB-UHFFFAOYSA-N 369045 N-[4-(6-methyl-7H-pyrrolo[2,3- d]pyrimidin-4-yl)phenyl]benzothiophene- 2-sulfonamide::US10227357, Compound P-0309 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369045 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369045&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114543 402365843 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729182 FC(F)c1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2ccc(Cl)cc2)cc1F InChI=1S/C19H12ClF3N4O2S/c20-10-1-4-12(5-2-10)30(28,29)27-11-3-6-13(15(21)7-11)17-14-8-16(18(22)23)26-19(14)25-9-24-17/h1-9,18,27H,(H,24,25,26) NYRZHSFUWIUHON-UHFFFAOYSA-N 369046 4-chloro-N-[4-[6-(difluoromethyl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]-3-fluoro- phenyl]benzenesulfonamide::US10227357, Compound P-0310 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369046 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369046&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90001568 402365844 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729183 CC(C)Oc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)-c1ncnc2[nH]c(C)cc12 InChI=1S/C22H22N4O3S/c1-14(2)29-18-8-10-19(11-9-18)30(27,28)26-17-6-4-16(5-7-17)21-20-12-15(3)25-22(20)24-13-23-21/h4-14,26H,1-3H3,(H,23,24,25) ZAVJRXWKNRDPLT-UHFFFAOYSA-N 369047 4-isopropoxy-N-[4-(6-methyl-7H- pyrrolo[2,3-d]pyrimidin-4- yl)phenyl]benzenesulfonamide::US10227357, Compound P-0311 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369047 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369047&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90001583 402365845 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729184 CC(C)Oc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)-c1ncnc2[nH]c(C)cc12 InChI=1S/C22H22N4O3S/c1-14(2)29-18-8-10-19(11-9-18)30(27,28)26-17-6-4-16(5-7-17)21-20-12-15(3)25-22(20)24-13-23-21/h4-14,26H,1-3H3,(H,23,24,25) ZAVJRXWKNRDPLT-UHFFFAOYSA-N 369047 4-isopropoxy-N-[4-(6-methyl-7H- pyrrolo[2,3-d]pyrimidin-4- yl)phenyl]benzenesulfonamide::US10227357, Compound P-0311 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369047 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369047&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90001583 402365845 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729185 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2ccc(cn2)C(F)(F)F)cc1 InChI=1S/C19H14F3N5O2S/c1-11-8-15-17(24-10-25-18(15)26-11)12-2-5-14(6-3-12)27-30(28,29)16-7-4-13(9-23-16)19(20,21)22/h2-10,27H,1H3,(H,24,25,26) CTPKCKQAPSOTNT-UHFFFAOYSA-N 369048 N-[4-(6-methyl-7H-pyrrolo[2,3- d]pyrimidin-4-yl)phenyl]-5- (trifluoromethyl)pyridine-2-sulfonamide::US10227357, Compound P-0312 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369048 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369048&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90000883 402365846 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729186 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2ccc(C)s2)cc1 InChI=1S/C18H16N4O2S2/c1-11-9-15-17(19-10-20-18(15)21-11)13-4-6-14(7-5-13)22-26(23,24)16-8-3-12(2)25-16/h3-10,22H,1-2H3,(H,19,20,21) UYEKTMGRXHTKPN-UHFFFAOYSA-N 369049 5-methyl-N-[4-(6-methyl-7H-pyrrolo[2,3- d]pyrimidin-4-yl)phenyl]thiophene-2- sulfonamide::US10227357, Compound P-0313 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369049 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369049&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90001154 402365847 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729187 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2ccc(C)s2)cc1 InChI=1S/C18H16N4O2S2/c1-11-9-15-17(19-10-20-18(15)21-11)13-4-6-14(7-5-13)22-26(23,24)16-8-3-12(2)25-16/h3-10,22H,1-2H3,(H,19,20,21) UYEKTMGRXHTKPN-UHFFFAOYSA-N 369049 5-methyl-N-[4-(6-methyl-7H-pyrrolo[2,3- d]pyrimidin-4-yl)phenyl]thiophene-2- sulfonamide::US10227357, Compound P-0313 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369049 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369049&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90001154 402365847 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729188 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2ccc(F)c(F)c2)cc1 InChI=1S/C19H14F2N4O2S/c1-11-8-15-18(22-10-23-19(15)24-11)12-2-4-13(5-3-12)25-28(26,27)14-6-7-16(20)17(21)9-14/h2-10,25H,1H3,(H,22,23,24) AMUXASXPFLLEAW-UHFFFAOYSA-N 369050 3,4-difluoro-N-[4-(6-methyl-7H- pyrrolo[2,3-d]pyrimidin-4- yl)phenyl]benzenesulfonamide::US10227357, Compound P-0314 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369050 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369050&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90001141 402365848 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729189 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2ccc(F)c(F)c2)cc1 InChI=1S/C19H14F2N4O2S/c1-11-8-15-18(22-10-23-19(15)24-11)12-2-4-13(5-3-12)25-28(26,27)14-6-7-16(20)17(21)9-14/h2-10,25H,1H3,(H,22,23,24) AMUXASXPFLLEAW-UHFFFAOYSA-N 369050 3,4-difluoro-N-[4-(6-methyl-7H- pyrrolo[2,3-d]pyrimidin-4- yl)phenyl]benzenesulfonamide::US10227357, Compound P-0314 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369050 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369050&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90001141 402365848 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729190 CCc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)-c1ncnc2[nH]c(C)cc12 InChI=1S/C21H20N4O2S/c1-3-15-4-10-18(11-5-15)28(26,27)25-17-8-6-16(7-9-17)20-19-12-14(2)24-21(19)23-13-22-20/h4-13,25H,3H2,1-2H3,(H,22,23,24) POKOVAWTRPARCV-UHFFFAOYSA-N 369051 4-ethyl-N-[4-(6-methyl-7H-pyrrolo[2,3- d]pyrimidin-4- yl)phenyl]benzenesulfonamide::US10227357, Compound P-0315 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369051 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369051&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90001897 402365849 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729191 CCc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)-c1ncnc2[nH]c(C)cc12 InChI=1S/C21H20N4O2S/c1-3-15-4-10-18(11-5-15)28(26,27)25-17-8-6-16(7-9-17)20-19-12-14(2)24-21(19)23-13-22-20/h4-13,25H,3H2,1-2H3,(H,22,23,24) POKOVAWTRPARCV-UHFFFAOYSA-N 369051 4-ethyl-N-[4-(6-methyl-7H-pyrrolo[2,3- d]pyrimidin-4- yl)phenyl]benzenesulfonamide::US10227357, Compound P-0315 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369051 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369051&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90001897 402365849 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729192 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2ccc(Cl)c(Cl)c2)cc1 InChI=1S/C19H14Cl2N4O2S/c1-11-8-15-18(22-10-23-19(15)24-11)12-2-4-13(5-3-12)25-28(26,27)14-6-7-16(20)17(21)9-14/h2-10,25H,1H3,(H,22,23,24) CIKXYXWCAPLYQS-UHFFFAOYSA-N 369052 3,4-dichloro-N-[4-(6-methyl-7H- pyrrolo[2,3-d]pyrimidin-4- yl)phenyl]benzenesulfonamide::US10227357, Compound P-0316 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369052 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369052&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90001674 402365850 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729193 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2ccc(cc2)C(F)(F)F)cc1 InChI=1S/C20H15F3N4O2S/c1-12-10-17-18(24-11-25-19(17)26-12)13-2-6-15(7-3-13)27-30(28,29)16-8-4-14(5-9-16)20(21,22)23/h2-11,27H,1H3,(H,24,25,26) RQHIENUTNDWIIH-UHFFFAOYSA-N 369053 N-[4-(6-methyl-7H-pyrrolo[2,3- d]pyrimidin-4-yl)phenyl]-4- (trifluoromethyl)benzenesulfonamide::US10227357, Compound P-0317 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369053&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115113 402365851 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729194 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2ccc(cc2)C(F)(F)F)cc1 InChI=1S/C20H15F3N4O2S/c1-12-10-17-18(24-11-25-19(17)26-12)13-2-6-15(7-3-13)27-30(28,29)16-8-4-14(5-9-16)20(21,22)23/h2-11,27H,1H3,(H,24,25,26) RQHIENUTNDWIIH-UHFFFAOYSA-N 369053 N-[4-(6-methyl-7H-pyrrolo[2,3- d]pyrimidin-4-yl)phenyl]-4- (trifluoromethyl)benzenesulfonamide::US10227357, Compound P-0317 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369053&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115113 402365851 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729195 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2ccc(Br)cc2)cc1 InChI=1S/C19H15BrN4O2S/c1-12-10-17-18(21-11-22-19(17)23-12)13-2-6-15(7-3-13)24-27(25,26)16-8-4-14(20)5-9-16/h2-11,24H,1H3,(H,21,22,23) FGCKUJFBSZBCAW-UHFFFAOYSA-N 369054 4-bromo-N-[4-(6-methyl-7H-pyrrolo[2,3- d]pyrimidin-4- yl)phenyl]benzenesulfonamide::US10227357, Compound P-0318 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369054 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369054&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114502 402365852 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729196 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2ccc(Br)cc2)cc1 InChI=1S/C19H15BrN4O2S/c1-12-10-17-18(21-11-22-19(17)23-12)13-2-6-15(7-3-13)24-27(25,26)16-8-4-14(20)5-9-16/h2-11,24H,1H3,(H,21,22,23) FGCKUJFBSZBCAW-UHFFFAOYSA-N 369054 4-bromo-N-[4-(6-methyl-7H-pyrrolo[2,3- d]pyrimidin-4- yl)phenyl]benzenesulfonamide::US10227357, Compound P-0318 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369054 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369054&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114502 402365852 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729197 CNS(=O)(=O)c1cccc(c1)-c1ncnc2[nH]c(C)cc12 InChI=1S/C14H14N4O2S/c1-9-6-12-13(16-8-17-14(12)18-9)10-4-3-5-11(7-10)21(19,20)15-2/h3-8,15H,1-2H3,(H,16,17,18) XJIZMOKHERFDLB-UHFFFAOYSA-N 369055 N-methyl-3-(6-methyl-7H-pyrrolo[2,3- d]pyrimidin-4-yl)benzenesulfonamide::US10227357, Compound P-0319 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369055&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114928 402365853 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729198 CNS(=O)(=O)c1cccc(c1)-c1ncnc2[nH]c(C)cc12 InChI=1S/C14H14N4O2S/c1-9-6-12-13(16-8-17-14(12)18-9)10-4-3-5-11(7-10)21(19,20)15-2/h3-8,15H,1-2H3,(H,16,17,18) XJIZMOKHERFDLB-UHFFFAOYSA-N 369055 N-methyl-3-(6-methyl-7H-pyrrolo[2,3- d]pyrimidin-4-yl)benzenesulfonamide::US10227357, Compound P-0319 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369055&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114928 402365853 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729199 Cc1cc2c(ncnc2[nH]1)-c1cccc(NS(C)(=O)=O)c1 InChI=1S/C14H14N4O2S/c1-9-6-12-13(15-8-16-14(12)17-9)10-4-3-5-11(7-10)18-21(2,19)20/h3-8,18H,1-2H3,(H,15,16,17) OOAZLWJKYKOECF-UHFFFAOYSA-N 369056 N-[3-(6-methyl-7H-pyrrolo[2,3- d]pyrimidin-4- yl)phenyl]methanesulfonamide::US10227357, Compound P-0320 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369056 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369056&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114769 402365854 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729200 Cc1cc2c(ncnc2[nH]1)-c1cccc(NS(C)(=O)=O)c1 InChI=1S/C14H14N4O2S/c1-9-6-12-13(15-8-16-14(12)17-9)10-4-3-5-11(7-10)18-21(2,19)20/h3-8,18H,1-2H3,(H,15,16,17) OOAZLWJKYKOECF-UHFFFAOYSA-N 369056 N-[3-(6-methyl-7H-pyrrolo[2,3- d]pyrimidin-4- yl)phenyl]methanesulfonamide::US10227357, Compound P-0320 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369056 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369056&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114769 402365854 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729201 Fc1ccc(cc1)S(=O)(=O)Nc1ccc(c(F)c1)-c1ncnc2[nH]c(cc12)C1=CCCC1 InChI=1S/C23H18F2N4O2S/c24-15-5-8-17(9-6-15)32(30,31)29-16-7-10-18(20(25)11-16)22-19-12-21(14-3-1-2-4-14)28-23(19)27-13-26-22/h3,5-13,29H,1-2,4H2,(H,26,27,28) GTSMWKWPOQMWFH-UHFFFAOYSA-N 369057 N-[4-[6-(cyclopenten-1-yl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]-3-fluoro- phenyl]-4-fluoro-benzenesulfonamide::US10227357, Compound P-0321 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369057 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369057&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115141 402365855 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729202 Fc1ccc(cc1)S(=O)(=O)Nc1ccc(c(F)c1)-c1ncnc2[nH]c(cc12)C1=CCCC1 InChI=1S/C23H18F2N4O2S/c24-15-5-8-17(9-6-15)32(30,31)29-16-7-10-18(20(25)11-16)22-19-12-21(14-3-1-2-4-14)28-23(19)27-13-26-22/h3,5-13,29H,1-2,4H2,(H,26,27,28) GTSMWKWPOQMWFH-UHFFFAOYSA-N 369057 N-[4-[6-(cyclopenten-1-yl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]-3-fluoro- phenyl]-4-fluoro-benzenesulfonamide::US10227357, Compound P-0321 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369057 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369057&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115141 402365855 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729203 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2cnn(c2)C(F)F)cc1 InChI=1S/C17H14F2N6O2S/c1-10-6-14-15(20-9-21-16(14)23-10)11-2-4-12(5-3-11)24-28(26,27)13-7-22-25(8-13)17(18)19/h2-9,17,24H,1H3,(H,20,21,23) MLXJTUQASIJUKG-UHFFFAOYSA-N 369058 1-(difluoromethyl)-N-[4-(6-methyl-7H- pyrrolo[2,3-d]pyrimidin-4- yl)phenyl]pyrazole-4-sulfonamide::US10227357, Compound P-0322 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369058 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369058&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114452 402365856 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729204 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2cnn(c2)C(F)F)cc1 InChI=1S/C17H14F2N6O2S/c1-10-6-14-15(20-9-21-16(14)23-10)11-2-4-12(5-3-11)24-28(26,27)13-7-22-25(8-13)17(18)19/h2-9,17,24H,1H3,(H,20,21,23) MLXJTUQASIJUKG-UHFFFAOYSA-N 369058 1-(difluoromethyl)-N-[4-(6-methyl-7H- pyrrolo[2,3-d]pyrimidin-4- yl)phenyl]pyrazole-4-sulfonamide::US10227357, Compound P-0322 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369058 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369058&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114452 402365856 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729205 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2ccc(Cl)s2)cc1 InChI=1S/C17H13ClN4O2S2/c1-10-8-13-16(19-9-20-17(13)21-10)11-2-4-12(5-3-11)22-26(23,24)15-7-6-14(18)25-15/h2-9,22H,1H3,(H,19,20,21) FWDUMCNDRNCJSX-UHFFFAOYSA-N 369059 5-chloro-N-[4-(6-methyl-7H-pyrrolo[2,3- d]pyrimidin-4-yl)phenyl]thiophene-2- sulfonamide::US10227357, Compound P-0323 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369059 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369059&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115062 402365857 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729206 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2ccc(Cl)s2)cc1 InChI=1S/C17H13ClN4O2S2/c1-10-8-13-16(19-9-20-17(13)21-10)11-2-4-12(5-3-11)22-26(23,24)15-7-6-14(18)25-15/h2-9,22H,1H3,(H,19,20,21) FWDUMCNDRNCJSX-UHFFFAOYSA-N 369059 5-chloro-N-[4-(6-methyl-7H-pyrrolo[2,3- d]pyrimidin-4-yl)phenyl]thiophene-2- sulfonamide::US10227357, Compound P-0323 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369059 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369059&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115062 402365857 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729207 COc1ccc(cn1)S(=O)(=O)Nc1ccc(cc1)-c1ncnc2[nH]c(C)cc12 InChI=1S/C19H17N5O3S/c1-12-9-16-18(21-11-22-19(16)23-12)13-3-5-14(6-4-13)24-28(25,26)15-7-8-17(27-2)20-10-15/h3-11,24H,1-2H3,(H,21,22,23) HZVIEWPJMZSJIW-UHFFFAOYSA-N 369060 6-methoxy-N-[4-(6-methyl-7H- pyrrolo[2,3-d]pyrimidin-4- yl)phenyl]pyridine-3-sulfonamide::US10227357, Compound P-0324 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369060 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369060&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114389 402365858 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729208 COc1ccc(cn1)S(=O)(=O)Nc1ccc(cc1)-c1ncnc2[nH]c(C)cc12 InChI=1S/C19H17N5O3S/c1-12-9-16-18(21-11-22-19(16)23-12)13-3-5-14(6-4-13)24-28(25,26)15-7-8-17(27-2)20-10-15/h3-11,24H,1-2H3,(H,21,22,23) HZVIEWPJMZSJIW-UHFFFAOYSA-N 369060 6-methoxy-N-[4-(6-methyl-7H- pyrrolo[2,3-d]pyrimidin-4- yl)phenyl]pyridine-3-sulfonamide::US10227357, Compound P-0324 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369060 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369060&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114389 402365858 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729209 COc1ccc(cc1F)S(=O)(=O)Nc1ccc(cc1)-c1ncnc2[nH]c(C)cc12 InChI=1S/C20H17FN4O3S/c1-12-9-16-19(22-11-23-20(16)24-12)13-3-5-14(6-4-13)25-29(26,27)15-7-8-18(28-2)17(21)10-15/h3-11,25H,1-2H3,(H,22,23,24) CXXCGFHQHHIIHR-UHFFFAOYSA-N 369061 3-fluoro-4-methoxy-N-[4-(6-methyl-7H- pyrrolo[2,3-d]pyrimidin-4- yl)phenyl]benzenesulfonamide::US10227357, Compound P-0325 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369061 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369061&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114431 402365859 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729210 COc1ccc(cc1F)S(=O)(=O)Nc1ccc(cc1)-c1ncnc2[nH]c(C)cc12 InChI=1S/C20H17FN4O3S/c1-12-9-16-19(22-11-23-20(16)24-12)13-3-5-14(6-4-13)25-29(26,27)15-7-8-18(28-2)17(21)10-15/h3-11,25H,1-2H3,(H,22,23,24) CXXCGFHQHHIIHR-UHFFFAOYSA-N 369061 3-fluoro-4-methoxy-N-[4-(6-methyl-7H- pyrrolo[2,3-d]pyrimidin-4- yl)phenyl]benzenesulfonamide::US10227357, Compound P-0325 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369061 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369061&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114431 402365859 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729211 COc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)-c1ncnc2[nH]c(C)cc12 InChI=1S/C20H18N4O3S/c1-13-11-18-19(21-12-22-20(18)23-13)14-3-5-15(6-4-14)24-28(25,26)17-9-7-16(27-2)8-10-17/h3-12,24H,1-2H3,(H,21,22,23) JAMGPCYWZWIXJK-UHFFFAOYSA-N 369062 4-methoxy-N-[4-(6-methyl-7H- pyrrolo[2,3-d]pyrimidin-4- yl)phenyl]benzenesulfonamide::US10227357, Compound P-0326 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369062 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369062&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114899 402365860 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729212 COc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)-c1ncnc2[nH]c(C)cc12 InChI=1S/C20H18N4O3S/c1-13-11-18-19(21-12-22-20(18)23-13)14-3-5-15(6-4-14)24-28(25,26)17-9-7-16(27-2)8-10-17/h3-12,24H,1-2H3,(H,21,22,23) JAMGPCYWZWIXJK-UHFFFAOYSA-N 369062 4-methoxy-N-[4-(6-methyl-7H- pyrrolo[2,3-d]pyrimidin-4- yl)phenyl]benzenesulfonamide::US10227357, Compound P-0326 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369062 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369062&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114899 402365860 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729213 Fc1ccc(cc1)-c1cc2c(ncnc2[nH]1)-c1ccc(cc1F)S(=O)(=O)Nc1ccc(Cl)cc1 InChI=1S/C24H15ClF2N4O2S/c25-15-3-7-17(8-4-15)31-34(32,33)18-9-10-19(21(27)11-18)23-20-12-22(30-24(20)29-13-28-23)14-1-5-16(26)6-2-14/h1-13,31H,(H,28,29,30) CRBWUHVLSKHWPN-UHFFFAOYSA-N 369063 N-(4-chlorophenyl)-3-fluoro-4-[6-(4- fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]benzenesulfonamide::US10227357, Compound P-0327 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369063 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369063&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114885 402365861 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729214 Fc1ccc(cc1)-c1cc2c(ncnc2[nH]1)-c1ccc(cc1F)S(=O)(=O)Nc1ccc(Cl)cc1 InChI=1S/C24H15ClF2N4O2S/c25-15-3-7-17(8-4-15)31-34(32,33)18-9-10-19(21(27)11-18)23-20-12-22(30-24(20)29-13-28-23)14-1-5-16(26)6-2-14/h1-13,31H,(H,28,29,30) CRBWUHVLSKHWPN-UHFFFAOYSA-N 369063 N-(4-chlorophenyl)-3-fluoro-4-[6-(4- fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]benzenesulfonamide::US10227357, Compound P-0327 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369063 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369063&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114885 402365861 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729215 Fc1ccc(NS(=O)(=O)c2ccc(c(F)c2)-c2ncnc3[nH]c(cc23)-c2ccc(F)cc2)cc1 InChI=1S/C24H15F3N4O2S/c25-15-3-1-14(2-4-15)22-12-20-23(28-13-29-24(20)30-22)19-10-9-18(11-21(19)27)34(32,33)31-17-7-5-16(26)6-8-17/h1-13,31H,(H,28,29,30) AACKXFBJASCUKR-UHFFFAOYSA-N 369064 3-fluoro-N-(4-fluorophenyl)-4-[6-(4- fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]benzenesulfonamide::US10227357, Compound P-0328 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369064 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369064&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114552 402365862 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729216 Fc1ccc(NS(=O)(=O)c2ccc(c(F)c2)-c2ncnc3[nH]c(cc23)-c2ccc(F)cc2)cc1 InChI=1S/C24H15F3N4O2S/c25-15-3-1-14(2-4-15)22-12-20-23(28-13-29-24(20)30-22)19-10-9-18(11-21(19)27)34(32,33)31-17-7-5-16(26)6-8-17/h1-13,31H,(H,28,29,30) AACKXFBJASCUKR-UHFFFAOYSA-N 369064 3-fluoro-N-(4-fluorophenyl)-4-[6-(4- fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]benzenesulfonamide::US10227357, Compound P-0328 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369064 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369064&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114552 402365862 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729217 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2ccc(OC(F)F)cc2)cc1 InChI=1S/C20H16F2N4O3S/c1-12-10-17-18(23-11-24-19(17)25-12)13-2-4-14(5-3-13)26-30(27,28)16-8-6-15(7-9-16)29-20(21)22/h2-11,20,26H,1H3,(H,23,24,25) QOILMZOWZDKZQA-UHFFFAOYSA-N 369065 4-(difluoromethoxy)-N-[4-(6-methyl-7H- pyrrolo[2,3-d]pyrimidin-4- yl)phenyl]benzenesulfonamide::US10227357, Compound P-0329 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369065 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369065&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115434 402365863 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729218 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2ccc(OC(F)F)cc2)cc1 InChI=1S/C20H16F2N4O3S/c1-12-10-17-18(23-11-24-19(17)25-12)13-2-4-14(5-3-13)26-30(27,28)16-8-6-15(7-9-16)29-20(21)22/h2-11,20,26H,1H3,(H,23,24,25) QOILMZOWZDKZQA-UHFFFAOYSA-N 369065 4-(difluoromethoxy)-N-[4-(6-methyl-7H- pyrrolo[2,3-d]pyrimidin-4- yl)phenyl]benzenesulfonamide::US10227357, Compound P-0329 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369065 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369065&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115434 402365863 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729219 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2ccc(Cl)cc2)cc1 InChI=1S/C19H15ClN4O2S/c1-12-10-17-18(21-11-22-19(17)23-12)13-2-6-15(7-3-13)24-27(25,26)16-8-4-14(20)5-9-16/h2-11,24H,1H3,(H,21,22,23) IDZGYSXIEVJDPK-UHFFFAOYSA-N 369066 4-chloro-N-[4-(6-methyl-7H-pyrrolo[2,3- d]pyrimidin-4- yl)phenyl]benzenesulfonamide::US10227357, Compound P-0330 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369066 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369066&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114315 402365864 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729220 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2ccc(Cl)cc2)cc1 InChI=1S/C19H15ClN4O2S/c1-12-10-17-18(21-11-22-19(17)23-12)13-2-6-15(7-3-13)24-27(25,26)16-8-4-14(20)5-9-16/h2-11,24H,1H3,(H,21,22,23) IDZGYSXIEVJDPK-UHFFFAOYSA-N 369066 4-chloro-N-[4-(6-methyl-7H-pyrrolo[2,3- d]pyrimidin-4- yl)phenyl]benzenesulfonamide::US10227357, Compound P-0330 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369066 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369066&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114315 402365864 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729221 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2ccc(F)cc2)cc1 InChI=1S/C19H15FN4O2S/c1-12-10-17-18(21-11-22-19(17)23-12)13-2-6-15(7-3-13)24-27(25,26)16-8-4-14(20)5-9-16/h2-11,24H,1H3,(H,21,22,23) ILWZOWOMXQKBFK-UHFFFAOYSA-N 369067 4-fluoro-N-[4-(6-methyl-7H-pyrrolo[2,3- d]pyrimidin-4- yl)phenyl]benzenesulfonamide::US10227357, Compound P-0331 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369067 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369067&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114378 402365865 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729222 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2ccc(F)cc2)cc1 InChI=1S/C19H15FN4O2S/c1-12-10-17-18(21-11-22-19(17)23-12)13-2-6-15(7-3-13)24-27(25,26)16-8-4-14(20)5-9-16/h2-11,24H,1H3,(H,21,22,23) ILWZOWOMXQKBFK-UHFFFAOYSA-N 369067 4-fluoro-N-[4-(6-methyl-7H-pyrrolo[2,3- d]pyrimidin-4- yl)phenyl]benzenesulfonamide::US10227357, Compound P-0331 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369067 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369067&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114378 402365865 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729223 Fc1ccc(cc1)S(=O)(=O)Nc1ccc(c(F)c1)-c1ncnc2[nH]c(cc12)-c1ccc(F)cc1F InChI=1S/C24H14F4N4O2S/c25-13-1-5-16(6-2-13)35(33,34)32-15-4-8-18(21(28)10-15)23-19-11-22(31-24(19)30-12-29-23)17-7-3-14(26)9-20(17)27/h1-12,32H,(H,29,30,31) KPTQAHJFNCLGFP-UHFFFAOYSA-N 369068 N-[4-[6-(2,4-difluorophenyl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]-3-fluoro- phenyl]-4-fluoro-benzenesulfonamide::US10227357, Compound P-0332 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369068 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369068&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115381 402365866 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729224 CS(=O)(=O)Nc1ccc(c(F)c1)-c1ncnc2[nH]c(cc12)-c1ccc(F)cc1F InChI=1S/C19H13F3N4O2S/c1-29(27,28)26-11-3-5-13(16(22)7-11)18-14-8-17(25-19(14)24-9-23-18)12-4-2-10(20)6-15(12)21/h2-9,26H,1H3,(H,23,24,25) VGZUIIQFAHBBKD-UHFFFAOYSA-N 369069 N-[4-[6-(2,4-difluorophenyl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]-3-fluoro- phenyl]methanesulfonamide::US10227357, Compound P-0333 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369069 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369069&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114547 402365867 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729225 CS(=O)(=O)Nc1ccc(c(F)c1)-c1ncnc2[nH]c(cc12)-c1ccc(F)cc1F InChI=1S/C19H13F3N4O2S/c1-29(27,28)26-11-3-5-13(16(22)7-11)18-14-8-17(25-19(14)24-9-23-18)12-4-2-10(20)6-15(12)21/h2-9,26H,1H3,(H,23,24,25) VGZUIIQFAHBBKD-UHFFFAOYSA-N 369069 N-[4-[6-(2,4-difluorophenyl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]-3-fluoro- phenyl]methanesulfonamide::US10227357, Compound P-0333 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369069 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369069&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114547 402365867 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729226 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2cc(F)ccc2F)cc1F InChI=1S/C19H13F3N4O2S/c1-10-6-14-18(23-9-24-19(14)25-10)13-4-3-12(8-16(13)22)26-29(27,28)17-7-11(20)2-5-15(17)21/h2-9,26H,1H3,(H,23,24,25) PMLVJQVXDZOULF-UHFFFAOYSA-N 369070 2,5-difluoro-N-[3-fluoro-4-(6-methyl-7H- pyrrolo[2,3-d]pyrimidin-4- yl)phenyl]benzenesulfonamide::US10227357, Compound P-0335 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369070 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369070&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115355 402365868 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729227 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2cc(F)ccc2F)cc1F InChI=1S/C19H13F3N4O2S/c1-10-6-14-18(23-9-24-19(14)25-10)13-4-3-12(8-16(13)22)26-29(27,28)17-7-11(20)2-5-15(17)21/h2-9,26H,1H3,(H,23,24,25) PMLVJQVXDZOULF-UHFFFAOYSA-N 369070 2,5-difluoro-N-[3-fluoro-4-(6-methyl-7H- pyrrolo[2,3-d]pyrimidin-4- yl)phenyl]benzenesulfonamide::US10227357, Compound P-0335 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369070 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369070&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115355 402365868 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729228 Cc1cc2c(ncnc2[nH]1)-c1ccc(cc1F)S(=O)(=O)Nc1ccc(F)cc1 InChI=1S/C19H14F2N4O2S/c1-11-8-16-18(22-10-23-19(16)24-11)15-7-6-14(9-17(15)21)28(26,27)25-13-4-2-12(20)3-5-13/h2-10,25H,1H3,(H,22,23,24) HLMWAIMVAZOIIC-UHFFFAOYSA-N 369071 3-fluoro-N-(4-fluorophenyl)-4-(6-methyl- 7H-pyrrolo[2,3-d]pyrimidin-4- yl)benzenesulfonamide::US10227357, Compound P-0336 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369071 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369071&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114595 402365869 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729229 Cc1cc2c(ncnc2[nH]1)-c1ccc(cc1F)S(=O)(=O)Nc1ccc(F)cc1 InChI=1S/C19H14F2N4O2S/c1-11-8-16-18(22-10-23-19(16)24-11)15-7-6-14(9-17(15)21)28(26,27)25-13-4-2-12(20)3-5-13/h2-10,25H,1H3,(H,22,23,24) HLMWAIMVAZOIIC-UHFFFAOYSA-N 369071 3-fluoro-N-(4-fluorophenyl)-4-(6-methyl- 7H-pyrrolo[2,3-d]pyrimidin-4- yl)benzenesulfonamide::US10227357, Compound P-0336 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369071 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369071&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114595 402365869 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729230 Fc1ccc(F)c(c1)-c1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2ccc(Cl)cc2)cc1F InChI=1S/C24H14ClF3N4O2S/c25-13-1-5-16(6-2-13)35(33,34)32-15-4-7-17(21(28)10-15)23-19-11-22(31-24(19)30-12-29-23)18-9-14(26)3-8-20(18)27/h1-12,32H,(H,29,30,31) QFHDCTQBFNFHOB-UHFFFAOYSA-N 369072 4-chloro-N-[4-[6-(2,5-difluorophenyl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]-3-fluoro- phenyl]benzenesulfonamide::US10227357, Compound P-0337 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369072 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369072&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90113978 402365870 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729231 Fc1ccc(F)c(c1)-c1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2ccc(Cl)cc2)cc1F InChI=1S/C24H14ClF3N4O2S/c25-13-1-5-16(6-2-13)35(33,34)32-15-4-7-17(21(28)10-15)23-19-11-22(31-24(19)30-12-29-23)18-9-14(26)3-8-20(18)27/h1-12,32H,(H,29,30,31) QFHDCTQBFNFHOB-UHFFFAOYSA-N 369072 4-chloro-N-[4-[6-(2,5-difluorophenyl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]-3-fluoro- phenyl]benzenesulfonamide::US10227357, Compound P-0337 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369072 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369072&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90113978 402365870 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729232 Fc1ccc(F)c(c1)-c1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)C2CC2)cc1F InChI=1S/C21H15F3N4O2S/c22-11-1-6-17(23)15(7-11)19-9-16-20(25-10-26-21(16)27-19)14-5-2-12(8-18(14)24)28-31(29,30)13-3-4-13/h1-2,5-10,13,28H,3-4H2,(H,25,26,27) KZFJSRQYVJZDRS-UHFFFAOYSA-N 369073 N-[4-[6-(2,5-difluorophenyl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]-3-fluoro- phenyl]cyclopropanesulfonamide::US10227357, Compound P-0338 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369073 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369073&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114686 402365871 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729233 Fc1ccc(F)c(c1)-c1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)C2CC2)cc1F InChI=1S/C21H15F3N4O2S/c22-11-1-6-17(23)15(7-11)19-9-16-20(25-10-26-21(16)27-19)14-5-2-12(8-18(14)24)28-31(29,30)13-3-4-13/h1-2,5-10,13,28H,3-4H2,(H,25,26,27) KZFJSRQYVJZDRS-UHFFFAOYSA-N 369073 N-[4-[6-(2,5-difluorophenyl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]-3-fluoro- phenyl]cyclopropanesulfonamide::US10227357, Compound P-0338 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369073 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369073&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114686 402365871 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729234 CS(=O)(=O)Nc1ccc(c(F)c1)-c1ncnc2[nH]c(cc12)-c1cc(F)ccc1F InChI=1S/C19H13F3N4O2S/c1-29(27,28)26-11-3-4-12(16(22)7-11)18-14-8-17(25-19(14)24-9-23-18)13-6-10(20)2-5-15(13)21/h2-9,26H,1H3,(H,23,24,25) PGEJNFRJDSMZQN-UHFFFAOYSA-N 369074 N-[4-[6-(2,5-difluorophenyl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]-3-fluoro- phenyl]methanesulfonamide::US10227357, Compound P-0339 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369074 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369074&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114963 402365872 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729235 CS(=O)(=O)Nc1ccc(c(F)c1)-c1ncnc2[nH]c(cc12)-c1cc(F)ccc1F InChI=1S/C19H13F3N4O2S/c1-29(27,28)26-11-3-4-12(16(22)7-11)18-14-8-17(25-19(14)24-9-23-18)13-6-10(20)2-5-15(13)21/h2-9,26H,1H3,(H,23,24,25) PGEJNFRJDSMZQN-UHFFFAOYSA-N 369074 N-[4-[6-(2,5-difluorophenyl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]-3-fluoro- phenyl]methanesulfonamide::US10227357, Compound P-0339 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369074 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369074&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114963 402365872 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729236 Fc1ccc(-c2cc3c(ncnc3[nH]2)-c2ccc(NS(=O)(=O)C3CC3)cc2F)c(F)c1 InChI=1S/C21H15F3N4O2S/c22-11-1-5-14(17(23)7-11)19-9-16-20(25-10-26-21(16)27-19)15-6-2-12(8-18(15)24)28-31(29,30)13-3-4-13/h1-2,5-10,13,28H,3-4H2,(H,25,26,27) MOQXISQZUCPBDM-UHFFFAOYSA-N 369075 N-[4-[6-(2,4-difluorophenyl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]-3-fluoro- phenyl]cyclopropanesulfonamide::US10227357, Compound P-0340 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369075 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369075&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114811 402365873 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729237 Fc1ccc(-c2cc3c(ncnc3[nH]2)-c2ccc(NS(=O)(=O)C3CC3)cc2F)c(F)c1 InChI=1S/C21H15F3N4O2S/c22-11-1-5-14(17(23)7-11)19-9-16-20(25-10-26-21(16)27-19)15-6-2-12(8-18(15)24)28-31(29,30)13-3-4-13/h1-2,5-10,13,28H,3-4H2,(H,25,26,27) MOQXISQZUCPBDM-UHFFFAOYSA-N 369075 N-[4-[6-(2,4-difluorophenyl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]-3-fluoro- phenyl]cyclopropanesulfonamide::US10227357, Compound P-0340 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369075 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369075&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114811 402365873 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729238 Nc1ccc(c(F)c1)-c1ncnc2[nH]c(cc12)-c1ccc(F)cc1F InChI=1S/C18H11F3N4/c19-9-1-3-11(14(20)5-9)16-7-13-17(23-8-24-18(13)25-16)12-4-2-10(22)6-15(12)21/h1-8H,22H2,(H,23,24,25) ZDFKHXLNNULNPO-UHFFFAOYSA-N 369076 4-[6-(2,4-difluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-3-fluoro-aniline::US10227357, Compound P-0341 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369076 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369076&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 89993998 402365874 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729239 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2cc(F)cc(F)c2)cc1F InChI=1S/C19H13F3N4O2S/c1-10-4-16-18(23-9-24-19(16)25-10)15-3-2-13(8-17(15)22)26-29(27,28)14-6-11(20)5-12(21)7-14/h2-9,26H,1H3,(H,23,24,25) MWFHZFIYKSVJOJ-UHFFFAOYSA-N 369077 3,5-difluoro-N-[3-fluoro-4-(6-methyl-7H- pyrrolo[2,3-d]pyrimidin-4- yl)phenyl]benzenesulfonamide::US10227357, Compound P-0342 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369077 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369077&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115036 402365875 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729240 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2cc(F)cc(F)c2)cc1F InChI=1S/C19H13F3N4O2S/c1-10-4-16-18(23-9-24-19(16)25-10)15-3-2-13(8-17(15)22)26-29(27,28)14-6-11(20)5-12(21)7-14/h2-9,26H,1H3,(H,23,24,25) MWFHZFIYKSVJOJ-UHFFFAOYSA-N 369077 3,5-difluoro-N-[3-fluoro-4-(6-methyl-7H- pyrrolo[2,3-d]pyrimidin-4- yl)phenyl]benzenesulfonamide::US10227357, Compound P-0342 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369077 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369077&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115036 402365875 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729241 Cc1cc2c(ncnc2[nH]1)-c1ccc(c(F)c1)S(=O)(=O)Nc1ccc(F)cc1 InChI=1S/C19H14F2N4O2S/c1-11-8-15-18(22-10-23-19(15)24-11)12-2-7-17(16(21)9-12)28(26,27)25-14-5-3-13(20)4-6-14/h2-10,25H,1H3,(H,22,23,24) TUDTZXXITCFVNO-UHFFFAOYSA-N 369078 2-fluoro-N-(4-fluorophenyl)-4-(6-methyl- 7H-pyrrolo[2,3-d]pyrimidin-4- yl)benzenesulfonamide::US10227357, Compound P-0343 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369078 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369078&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114180 402365876 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729242 Cc1cc2c(ncnc2[nH]1)-c1ccc(c(F)c1)S(=O)(=O)Nc1ccc(F)cc1 InChI=1S/C19H14F2N4O2S/c1-11-8-15-18(22-10-23-19(15)24-11)12-2-7-17(16(21)9-12)28(26,27)25-14-5-3-13(20)4-6-14/h2-10,25H,1H3,(H,22,23,24) TUDTZXXITCFVNO-UHFFFAOYSA-N 369078 2-fluoro-N-(4-fluorophenyl)-4-(6-methyl- 7H-pyrrolo[2,3-d]pyrimidin-4- yl)benzenesulfonamide::US10227357, Compound P-0343 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369078 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369078&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114180 402365876 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729243 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2ccc(Cl)cc2)c(F)c1 InChI=1S/C19H14ClFN4O2S/c1-11-8-15-18(22-10-23-19(15)24-11)12-2-7-17(16(21)9-12)25-28(26,27)14-5-3-13(20)4-6-14/h2-10,25H,1H3,(H,22,23,24) HGFFGOJZNRGNDN-UHFFFAOYSA-N 369079 4-chloro-N-[2-fluoro-4-(6-methyl-7H- pyrrolo[2,3-d]pyrimidin-4- yl)phenyl]benzenesulfonamide::US10227357, Compound P-0344 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369079 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369079&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114354 402365877 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729244 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2ccc(Cl)cc2)c(F)c1 InChI=1S/C19H14ClFN4O2S/c1-11-8-15-18(22-10-23-19(15)24-11)12-2-7-17(16(21)9-12)25-28(26,27)14-5-3-13(20)4-6-14/h2-10,25H,1H3,(H,22,23,24) HGFFGOJZNRGNDN-UHFFFAOYSA-N 369079 4-chloro-N-[2-fluoro-4-(6-methyl-7H- pyrrolo[2,3-d]pyrimidin-4- yl)phenyl]benzenesulfonamide::US10227357, Compound P-0344 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369079 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369079&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114354 402365877 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729245 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2cccc(Cl)c2)c(F)c1 InChI=1S/C19H14ClFN4O2S/c1-11-7-15-18(22-10-23-19(15)24-11)12-5-6-17(16(21)8-12)25-28(26,27)14-4-2-3-13(20)9-14/h2-10,25H,1H3,(H,22,23,24) NFOVAMQGEYFLKA-UHFFFAOYSA-N 369080 3-chloro-N-[2-fluoro-4-(6-methyl-7H- pyrrolo[2,3-d]pyrimidin-4- yl)phenyl]benzenesulfonamide::US10227357, Compound P-0345 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369080 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369080&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114874 402365878 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729246 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2cccc(Cl)c2)c(F)c1 InChI=1S/C19H14ClFN4O2S/c1-11-7-15-18(22-10-23-19(15)24-11)12-5-6-17(16(21)8-12)25-28(26,27)14-4-2-3-13(20)9-14/h2-10,25H,1H3,(H,22,23,24) NFOVAMQGEYFLKA-UHFFFAOYSA-N 369080 3-chloro-N-[2-fluoro-4-(6-methyl-7H- pyrrolo[2,3-d]pyrimidin-4- yl)phenyl]benzenesulfonamide::US10227357, Compound P-0345 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369080 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369080&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114874 402365878 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729247 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2ccc(F)cc2)c(F)c1 InChI=1S/C19H14F2N4O2S/c1-11-8-15-18(22-10-23-19(15)24-11)12-2-7-17(16(21)9-12)25-28(26,27)14-5-3-13(20)4-6-14/h2-10,25H,1H3,(H,22,23,24) NSAVEBUQBKZOCQ-UHFFFAOYSA-N 369081 4-fluoro-N-[2-fluoro-4-(6-methyl-7H- pyrrolo[2,3-d]pyrimidin-4- yl)phenyl]benzenesulfonamide::US10227357, Compound P-0346 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369081 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369081&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115264 402365879 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729248 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2ccc(F)cc2)c(F)c1 InChI=1S/C19H14F2N4O2S/c1-11-8-15-18(22-10-23-19(15)24-11)12-2-7-17(16(21)9-12)25-28(26,27)14-5-3-13(20)4-6-14/h2-10,25H,1H3,(H,22,23,24) NSAVEBUQBKZOCQ-UHFFFAOYSA-N 369081 4-fluoro-N-[2-fluoro-4-(6-methyl-7H- pyrrolo[2,3-d]pyrimidin-4- yl)phenyl]benzenesulfonamide::US10227357, Compound P-0346 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369081 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369081&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115264 402365879 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729249 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2cccc(F)c2)c(F)c1 InChI=1S/C19H14F2N4O2S/c1-11-7-15-18(22-10-23-19(15)24-11)12-5-6-17(16(21)8-12)25-28(26,27)14-4-2-3-13(20)9-14/h2-10,25H,1H3,(H,22,23,24) DMPVMORYJOLZMD-UHFFFAOYSA-N 369082 3-fluoro-N-[2-fluoro-4-(6-methyl-7H- pyrrolo[2,3-d]pyrimidin-4- yl)phenyl]benzenesulfonamide::US10227357, Compound P-0347 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369082 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369082&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115082 402365880 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729250 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2cccc(F)c2)c(F)c1 InChI=1S/C19H14F2N4O2S/c1-11-7-15-18(22-10-23-19(15)24-11)12-5-6-17(16(21)8-12)25-28(26,27)14-4-2-3-13(20)9-14/h2-10,25H,1H3,(H,22,23,24) DMPVMORYJOLZMD-UHFFFAOYSA-N 369082 3-fluoro-N-[2-fluoro-4-(6-methyl-7H- pyrrolo[2,3-d]pyrimidin-4- yl)phenyl]benzenesulfonamide::US10227357, Compound P-0347 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369082 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369082&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115082 402365880 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729251 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2ccccc2F)c(F)c1 InChI=1S/C19H14F2N4O2S/c1-11-8-13-18(22-10-23-19(13)24-11)12-6-7-16(15(21)9-12)25-28(26,27)17-5-3-2-4-14(17)20/h2-10,25H,1H3,(H,22,23,24) MRDZHRREWYWGCH-UHFFFAOYSA-N 369083 2-fluoro-N-[2-fluoro-4-(6-methyl-7H- pyrrolo[2,3-d]pyrimidin-4- yl)phenyl]benzenesulfonamide::US10227357, Compound P-0348 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369083 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369083&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114394 402365881 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729252 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2ccc(Cl)cc2)cc1F InChI=1S/C19H14ClFN4O2S/c1-11-8-16-18(22-10-23-19(16)24-11)15-7-4-13(9-17(15)21)25-28(26,27)14-5-2-12(20)3-6-14/h2-10,25H,1H3,(H,22,23,24) QULJCIXUHGDFFZ-UHFFFAOYSA-N 369084 4-chloro-N-[3-fluoro-4-(6-methyl-7H- pyrrolo[2,3-d]pyrimidin-4- yl)phenyl]benzenesulfonamide::US10227357, Compound P-0349 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369084 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369084&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114191 402365882 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729253 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2ccc(Cl)cc2)cc1F InChI=1S/C19H14ClFN4O2S/c1-11-8-16-18(22-10-23-19(16)24-11)15-7-4-13(9-17(15)21)25-28(26,27)14-5-2-12(20)3-6-14/h2-10,25H,1H3,(H,22,23,24) QULJCIXUHGDFFZ-UHFFFAOYSA-N 369084 4-chloro-N-[3-fluoro-4-(6-methyl-7H- pyrrolo[2,3-d]pyrimidin-4- yl)phenyl]benzenesulfonamide::US10227357, Compound P-0349 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369084 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369084&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114191 402365882 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729254 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2ccc(C)c(F)c2)c(F)c1 InChI=1S/C20H16F2N4O2S/c1-11-3-5-14(9-16(11)21)29(27,28)26-18-6-4-13(8-17(18)22)19-15-7-12(2)25-20(15)24-10-23-19/h3-10,26H,1-2H3,(H,23,24,25) KPZNVHUCFQYYNB-UHFFFAOYSA-N 369085 3-fluoro-N-[2-fluoro-4-(6-methyl-7H- pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-4- methyl-benzenesulfonamide::US10227357, Compound P-0350 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369085 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369085&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114462 402365883 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729255 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2ccc(C)c(F)c2)c(F)c1 InChI=1S/C20H16F2N4O2S/c1-11-3-5-14(9-16(11)21)29(27,28)26-18-6-4-13(8-17(18)22)19-15-7-12(2)25-20(15)24-10-23-19/h3-10,26H,1-2H3,(H,23,24,25) KPZNVHUCFQYYNB-UHFFFAOYSA-N 369085 3-fluoro-N-[2-fluoro-4-(6-methyl-7H- pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-4- methyl-benzenesulfonamide::US10227357, Compound P-0350 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369085 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369085&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114462 402365883 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729256 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2cccc(Cl)c2F)c(F)c1 InChI=1S/C19H13ClF2N4O2S/c1-10-7-12-18(23-9-24-19(12)25-10)11-5-6-15(14(21)8-11)26-29(27,28)16-4-2-3-13(20)17(16)22/h2-9,26H,1H3,(H,23,24,25) WFVKZBLCADDVIV-UHFFFAOYSA-N 369086 3-chloro-2-fluoro-N-[2-fluoro-4-(6- methyl-7H-pyrrolo[2,3-d]pyrimidin-4- yl)phenyl]benzenesulfonamide::US10227357, Compound P-0351 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369086 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369086&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114395 402365884 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729257 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2cccc(Cl)c2F)c(F)c1 InChI=1S/C19H13ClF2N4O2S/c1-10-7-12-18(23-9-24-19(12)25-10)11-5-6-15(14(21)8-11)26-29(27,28)16-4-2-3-13(20)17(16)22/h2-9,26H,1H3,(H,23,24,25) WFVKZBLCADDVIV-UHFFFAOYSA-N 369086 3-chloro-2-fluoro-N-[2-fluoro-4-(6- methyl-7H-pyrrolo[2,3-d]pyrimidin-4- yl)phenyl]benzenesulfonamide::US10227357, Compound P-0351 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369086 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369086&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114395 402365884 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729258 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2ccc(Cl)cc2F)cc1F InChI=1S/C19H13ClF2N4O2S/c1-10-6-14-18(23-9-24-19(14)25-10)13-4-3-12(8-15(13)21)26-29(27,28)17-5-2-11(20)7-16(17)22/h2-9,26H,1H3,(H,23,24,25) SWYKCBANJJEZOQ-UHFFFAOYSA-N 369087 4-chloro-2-fluoro-N-[3-fluoro-4-(6- methyl-7H-pyrrolo[2,3-d]pyrimidin-4- yl)phenyl]benzenesulfonamide::US10227357, Compound P-0352 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369087 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369087&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114747 402365885 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729259 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2ccc(Cl)cc2F)cc1F InChI=1S/C19H13ClF2N4O2S/c1-10-6-14-18(23-9-24-19(14)25-10)13-4-3-12(8-15(13)21)26-29(27,28)17-5-2-11(20)7-16(17)22/h2-9,26H,1H3,(H,23,24,25) SWYKCBANJJEZOQ-UHFFFAOYSA-N 369087 4-chloro-2-fluoro-N-[3-fluoro-4-(6- methyl-7H-pyrrolo[2,3-d]pyrimidin-4- yl)phenyl]benzenesulfonamide::US10227357, Compound P-0352 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369087 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369087&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114747 402365885 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729260 CS(=O)(=O)Nc1ccc(c(F)c1F)-c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 InChI=1S/C19H13F3N4O2S/c1-29(27,28)26-14-7-6-12(16(21)17(14)22)18-13-8-15(25-19(13)24-9-23-18)10-2-4-11(20)5-3-10/h2-9,26H,1H3,(H,23,24,25) NKNSGXTXZTYUQJ-UHFFFAOYSA-N 369088 N-[2,3-difluoro-4-[6-(4-fluorophenyl)-7H- pyrrolo[2,3-d]pyrimidin-4- yl]phenyl]methanesulfonamide::US10227357, Compound P-0353 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369088&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114177 402365886 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729261 CS(=O)(=O)Nc1ccc(c(F)c1F)-c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 InChI=1S/C19H13F3N4O2S/c1-29(27,28)26-14-7-6-12(16(21)17(14)22)18-13-8-15(25-19(13)24-9-23-18)10-2-4-11(20)5-3-10/h2-9,26H,1H3,(H,23,24,25) NKNSGXTXZTYUQJ-UHFFFAOYSA-N 369088 N-[2,3-difluoro-4-[6-(4-fluorophenyl)-7H- pyrrolo[2,3-d]pyrimidin-4- yl]phenyl]methanesulfonamide::US10227357, Compound P-0353 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369088&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114177 402365886 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729262 Fc1ccc(CNS(=O)(=O)c2ccc(c(F)c2)-c2ncnc3[nH]c(cc23)-c2ccc(F)cc2)cc1 InChI=1S/C25H17F3N4O2S/c26-17-5-1-15(2-6-17)13-31-35(33,34)19-9-10-20(22(28)11-19)24-21-12-23(32-25(21)30-14-29-24)16-3-7-18(27)8-4-16/h1-12,14,31H,13H2,(H,29,30,32) RILBWFGOUYASHO-UHFFFAOYSA-N 369089 3-fluoro-N-[(4-fluorophenyl)methyl]-4- [6-(4-fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]benzenesulfonamide::US10227357, Compound P-0354 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369089 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369089&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114813 402365887 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729263 Fc1ccc(CNS(=O)(=O)c2ccc(c(F)c2)-c2ncnc3[nH]c(cc23)-c2ccc(F)cc2)cc1 InChI=1S/C25H17F3N4O2S/c26-17-5-1-15(2-6-17)13-31-35(33,34)19-9-10-20(22(28)11-19)24-21-12-23(32-25(21)30-14-29-24)16-3-7-18(27)8-4-16/h1-12,14,31H,13H2,(H,29,30,32) RILBWFGOUYASHO-UHFFFAOYSA-N 369089 3-fluoro-N-[(4-fluorophenyl)methyl]-4- [6-(4-fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]benzenesulfonamide::US10227357, Compound P-0354 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369089 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369089&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114813 402365887 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729264 CS(=O)(=O)Nc1cc(F)c(cc1F)-c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 InChI=1S/C19H13F3N4O2S/c1-29(27,28)26-17-8-14(21)12(6-15(17)22)18-13-7-16(25-19(13)24-9-23-18)10-2-4-11(20)5-3-10/h2-9,26H,1H3,(H,23,24,25) WKBVVCQHRZZTQU-UHFFFAOYSA-N 369090 N-[2,5-difluoro-4-[6-(4-fluorophenyl)-7H- pyrrolo[2,3-d]pyrimidin-4- yl]phenyl]methanesulfonamide::US10227357, Compound P-0356 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369090 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369090&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115131 402365888 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729265 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2cccc(Cl)c2)cc1F InChI=1S/C19H14ClFN4O2S/c1-11-7-16-18(22-10-23-19(16)24-11)15-6-5-13(9-17(15)21)25-28(26,27)14-4-2-3-12(20)8-14/h2-10,25H,1H3,(H,22,23,24) PXSOVYHAVIKKDU-UHFFFAOYSA-N 369091 3-chloro-N-[3-fluoro-4-(6-methyl-7H- pyrrolo[2,3-d]pyrimidin-4- yl)phenyl]benzenesulfonamide::US10227357, Compound P-0357 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369091 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369091&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114465 402365889 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729266 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2cccc(Cl)c2)cc1F InChI=1S/C19H14ClFN4O2S/c1-11-7-16-18(22-10-23-19(16)24-11)15-6-5-13(9-17(15)21)25-28(26,27)14-4-2-3-12(20)8-14/h2-10,25H,1H3,(H,22,23,24) PXSOVYHAVIKKDU-UHFFFAOYSA-N 369091 3-chloro-N-[3-fluoro-4-(6-methyl-7H- pyrrolo[2,3-d]pyrimidin-4- yl)phenyl]benzenesulfonamide::US10227357, Compound P-0357 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369091 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369091&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114465 402365889 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729267 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2cccc(F)c2)cc1F InChI=1S/C19H14F2N4O2S/c1-11-7-16-18(22-10-23-19(16)24-11)15-6-5-13(9-17(15)21)25-28(26,27)14-4-2-3-12(20)8-14/h2-10,25H,1H3,(H,22,23,24) ZKAHVAAZDVMRPN-UHFFFAOYSA-N 369092 3-fluoro-N-[3-fluoro-4-(6-methyl-7H- pyrrolo[2,3-d]pyrimidin-4- yl)phenyl]benzenesulfonamide::US10227357, Compound P-0358 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369092 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369092&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115063 402365890 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729268 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2cccc(F)c2)cc1F InChI=1S/C19H14F2N4O2S/c1-11-7-16-18(22-10-23-19(16)24-11)15-6-5-13(9-17(15)21)25-28(26,27)14-4-2-3-12(20)8-14/h2-10,25H,1H3,(H,22,23,24) ZKAHVAAZDVMRPN-UHFFFAOYSA-N 369092 3-fluoro-N-[3-fluoro-4-(6-methyl-7H- pyrrolo[2,3-d]pyrimidin-4- yl)phenyl]benzenesulfonamide::US10227357, Compound P-0358 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369092 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369092&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115063 402365890 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729269 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2ccc(OC(F)F)cc2)c(F)c1 InChI=1S/C20H15F3N4O3S/c1-11-8-15-18(24-10-25-19(15)26-11)12-2-7-17(16(21)9-12)27-31(28,29)14-5-3-13(4-6-14)30-20(22)23/h2-10,20,27H,1H3,(H,24,25,26) ISRAZNPSDCANEW-UHFFFAOYSA-N 369093 4-(difluoromethoxy)-N-[2-fluoro-4-(6- methyl-7H-pyrrolo[2,3-d]pyrimidin-4- yl)phenyl]benzenesulfonamide::US10227357, Compound P-0360 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369093 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369093&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114661 402365891 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729270 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2ccc(OC(F)F)cc2)c(F)c1 InChI=1S/C20H15F3N4O3S/c1-11-8-15-18(24-10-25-19(15)26-11)12-2-7-17(16(21)9-12)27-31(28,29)14-5-3-13(4-6-14)30-20(22)23/h2-10,20,27H,1H3,(H,24,25,26) ISRAZNPSDCANEW-UHFFFAOYSA-N 369093 4-(difluoromethoxy)-N-[2-fluoro-4-(6- methyl-7H-pyrrolo[2,3-d]pyrimidin-4- yl)phenyl]benzenesulfonamide::US10227357, Compound P-0360 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369093 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369093&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114661 402365891 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729271 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2ccc(Cl)cc2F)c(F)c1 InChI=1S/C19H13ClF2N4O2S/c1-10-6-13-18(23-9-24-19(13)25-10)11-2-4-16(14(21)7-11)26-29(27,28)17-5-3-12(20)8-15(17)22/h2-9,26H,1H3,(H,23,24,25) QBGXFLBTVCHDAG-UHFFFAOYSA-N 369094 4-chloro-2-fluoro-N-[2-fluoro-4-(6- methyl-7H-pyrrolo[2,3-d]pyrimidin-4- yl)phenyl]benzenesulfonamide::US10227357, Compound P-0361 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369094 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369094&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114958 402365892 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729272 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2ccc(Cl)cc2F)c(F)c1 InChI=1S/C19H13ClF2N4O2S/c1-10-6-13-18(23-9-24-19(13)25-10)11-2-4-16(14(21)7-11)26-29(27,28)17-5-3-12(20)8-15(17)22/h2-9,26H,1H3,(H,23,24,25) QBGXFLBTVCHDAG-UHFFFAOYSA-N 369094 4-chloro-2-fluoro-N-[2-fluoro-4-(6- methyl-7H-pyrrolo[2,3-d]pyrimidin-4- yl)phenyl]benzenesulfonamide::US10227357, Compound P-0361 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369094 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369094&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114958 402365892 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729273 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2ccc(F)cc2)cc1F InChI=1S/C19H14F2N4O2S/c1-11-8-16-18(22-10-23-19(16)24-11)15-7-4-13(9-17(15)21)25-28(26,27)14-5-2-12(20)3-6-14/h2-10,25H,1H3,(H,22,23,24) XGLDDFSCJYBLBP-UHFFFAOYSA-N 369095 4-fluoro-N-[3-fluoro-4-(6-methyl-7H- pyrrolo[2,3-d]pyrimidin-4- yl)phenyl]benzenesulfonamide::US10227357, Compound P-0362 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369095 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369095&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115109 402365893 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729274 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2ccc(F)cc2)cc1F InChI=1S/C19H14F2N4O2S/c1-11-8-16-18(22-10-23-19(16)24-11)15-7-4-13(9-17(15)21)25-28(26,27)14-5-2-12(20)3-6-14/h2-10,25H,1H3,(H,22,23,24) XGLDDFSCJYBLBP-UHFFFAOYSA-N 369095 4-fluoro-N-[3-fluoro-4-(6-methyl-7H- pyrrolo[2,3-d]pyrimidin-4- yl)phenyl]benzenesulfonamide::US10227357, Compound P-0362 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369095 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369095&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115109 402365893 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729275 COc1ccc(cc1)S(=O)(=O)Nc1ccc(c(F)c1)-c1ncnc2[nH]c(C)cc12 InChI=1S/C20H17FN4O3S/c1-12-9-17-19(22-11-23-20(17)24-12)16-8-3-13(10-18(16)21)25-29(26,27)15-6-4-14(28-2)5-7-15/h3-11,25H,1-2H3,(H,22,23,24) UWTALTWBYKMREA-UHFFFAOYSA-N 369096 N-[3-fluoro-4-(6-methyl-7H-pyrrolo[2,3- d]pyrimidin-4-yl)phenyl]-4-methoxy- benzenesulfonamide::US10227357, Compound P-0363 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369096 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369096&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114587 402365894 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729276 COc1ccc(cc1)S(=O)(=O)Nc1ccc(c(F)c1)-c1ncnc2[nH]c(C)cc12 InChI=1S/C20H17FN4O3S/c1-12-9-17-19(22-11-23-20(17)24-12)16-8-3-13(10-18(16)21)25-29(26,27)15-6-4-14(28-2)5-7-15/h3-11,25H,1-2H3,(H,22,23,24) UWTALTWBYKMREA-UHFFFAOYSA-N 369096 N-[3-fluoro-4-(6-methyl-7H-pyrrolo[2,3- d]pyrimidin-4-yl)phenyl]-4-methoxy- benzenesulfonamide::US10227357, Compound P-0363 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369096 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369096&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114587 402365894 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729277 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2cccc(Cl)c2F)cc1F InChI=1S/C19H13ClF2N4O2S/c1-10-7-13-18(23-9-24-19(13)25-10)12-6-5-11(8-15(12)21)26-29(27,28)16-4-2-3-14(20)17(16)22/h2-9,26H,1H3,(H,23,24,25) GSSIAWALKUTMPB-UHFFFAOYSA-N 369097 3-chloro-2-fluoro-N-[3-fluoro-4-(6- methyl-7H-pyrrolo[2,3-d]pyrimidin-4- yl)phenyl]benzenesulfonamide::US10227357, Compound P-0364 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369097 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369097&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114893 402365895 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729278 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2cccc(Cl)c2F)cc1F InChI=1S/C19H13ClF2N4O2S/c1-10-7-13-18(23-9-24-19(13)25-10)12-6-5-11(8-15(12)21)26-29(27,28)16-4-2-3-14(20)17(16)22/h2-9,26H,1H3,(H,23,24,25) GSSIAWALKUTMPB-UHFFFAOYSA-N 369097 3-chloro-2-fluoro-N-[3-fluoro-4-(6- methyl-7H-pyrrolo[2,3-d]pyrimidin-4- yl)phenyl]benzenesulfonamide::US10227357, Compound P-0364 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369097 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369097&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114893 402365895 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729279 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2ccc(C)c(F)c2)cc1F InChI=1S/C20H16F2N4O2S/c1-11-3-5-14(9-17(11)21)29(27,28)26-13-4-6-15(18(22)8-13)19-16-7-12(2)25-20(16)24-10-23-19/h3-10,26H,1-2H3,(H,23,24,25) RRDVSXAOZCKUCH-UHFFFAOYSA-N 369098 3-fluoro-N-[3-fluoro-4-(6-methyl-7H- pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-4- methyl-benzenesulfonamide::US10227357, Compound P-0365 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369098 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369098&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115292 402365896 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729280 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2ccc(C)c(F)c2)cc1F InChI=1S/C20H16F2N4O2S/c1-11-3-5-14(9-17(11)21)29(27,28)26-13-4-6-15(18(22)8-13)19-16-7-12(2)25-20(16)24-10-23-19/h3-10,26H,1-2H3,(H,23,24,25) RRDVSXAOZCKUCH-UHFFFAOYSA-N 369098 3-fluoro-N-[3-fluoro-4-(6-methyl-7H- pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-4- methyl-benzenesulfonamide::US10227357, Compound P-0365 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369098 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369098&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115292 402365896 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729281 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2ccc(OC(F)F)cc2)cc1F InChI=1S/C20H15F3N4O3S/c1-11-8-16-18(24-10-25-19(16)26-11)15-7-2-12(9-17(15)21)27-31(28,29)14-5-3-13(4-6-14)30-20(22)23/h2-10,20,27H,1H3,(H,24,25,26) WEDHRNHOBXYZNZ-UHFFFAOYSA-N 369099 4-(difluoromethoxy)-N-[3-fluoro-4-(6- methyl-7H-pyrrolo[2,3-d]pyrimidin-4- yl)phenyl]benzenesulfonamide::US10227357, Compound P-0366 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369099 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369099&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 89993988 402365897 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729282 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2ccc(OC(F)F)cc2)cc1F InChI=1S/C20H15F3N4O3S/c1-11-8-16-18(24-10-25-19(16)26-11)15-7-2-12(9-17(15)21)27-31(28,29)14-5-3-13(4-6-14)30-20(22)23/h2-10,20,27H,1H3,(H,24,25,26) WEDHRNHOBXYZNZ-UHFFFAOYSA-N 369099 4-(difluoromethoxy)-N-[3-fluoro-4-(6- methyl-7H-pyrrolo[2,3-d]pyrimidin-4- yl)phenyl]benzenesulfonamide::US10227357, Compound P-0366 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369099 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369099&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 89993988 402365897 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729283 CS(=O)(=O)Nc1ccc(cc1F)-c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 InChI=1S/C19H14F2N4O2S/c1-28(26,27)25-16-7-4-12(8-15(16)21)18-14-9-17(24-19(14)23-10-22-18)11-2-5-13(20)6-3-11/h2-10,25H,1H3,(H,22,23,24) DITNDCGKUORJHQ-UHFFFAOYSA-N 369100 1,1,1-trideuterio-N-[2-fluoro-4-[6-(4- fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4- yl]phenyl]methanesulfonamide::US10227357, Compound P-0367::US10227357, Compound P-0399 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369100 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369100&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114845 402365898 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729284 CS(=O)(=O)Nc1ccc(cc1F)-c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 InChI=1S/C19H14F2N4O2S/c1-28(26,27)25-16-7-4-12(8-15(16)21)18-14-9-17(24-19(14)23-10-22-18)11-2-5-13(20)6-3-11/h2-10,25H,1H3,(H,22,23,24) DITNDCGKUORJHQ-UHFFFAOYSA-N 369100 1,1,1-trideuterio-N-[2-fluoro-4-[6-(4- fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4- yl]phenyl]methanesulfonamide::US10227357, Compound P-0367::US10227357, Compound P-0399 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369100 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369100&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114845 402365898 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729285 CS(=O)(=O)Nc1ccc(c(F)c1)-c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 InChI=1S/C19H14F2N4O2S/c1-28(26,27)25-13-6-7-14(16(21)8-13)18-15-9-17(24-19(15)23-10-22-18)11-2-4-12(20)5-3-11/h2-10,25H,1H3,(H,22,23,24) OFIMXXXMDAPOSN-UHFFFAOYSA-N 369101 1,1,1-trideuterio-N-[3-fluoro-4-[6-(4- fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4- yl]phenyl]methanesulfonamide::US10227357, Compound P-0368::US10227357, Compound P-0398 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369101 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369101&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114936 402365899 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729286 CS(=O)(=O)Nc1ccc(c(F)c1)-c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 InChI=1S/C19H14F2N4O2S/c1-28(26,27)25-13-6-7-14(16(21)8-13)18-15-9-17(24-19(15)23-10-22-18)11-2-4-12(20)5-3-11/h2-10,25H,1H3,(H,22,23,24) OFIMXXXMDAPOSN-UHFFFAOYSA-N 369101 1,1,1-trideuterio-N-[3-fluoro-4-[6-(4- fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4- yl]phenyl]methanesulfonamide::US10227357, Compound P-0368::US10227357, Compound P-0398 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369101 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369101&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114936 402365899 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729287 Fc1ccc(cc1)-c1cc2c(ncnc2[nH]1)-c1ccc(cc1F)S(=O)(=O)NCC1CC1 InChI=1S/C22H18F2N4O2S/c23-15-5-3-14(4-6-15)20-10-18-21(25-12-26-22(18)28-20)17-8-7-16(9-19(17)24)31(29,30)27-11-13-1-2-13/h3-10,12-13,27H,1-2,11H2,(H,25,26,28) PHSHGZGTOPKZOO-UHFFFAOYSA-N 369102 N-(cyclopropylmethyl)-3-fluoro-4-[6-(4- fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]benzenesulfonamide::US10227357, Compound P-0369 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369102 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369102&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114858 402365900 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729288 Fc1ccc(cc1)-c1cc2c(ncnc2[nH]1)-c1ccc(cc1F)S(=O)(=O)NCC1CC1 InChI=1S/C22H18F2N4O2S/c23-15-5-3-14(4-6-15)20-10-18-21(25-12-26-22(18)28-20)17-8-7-16(9-19(17)24)31(29,30)27-11-13-1-2-13/h3-10,12-13,27H,1-2,11H2,(H,25,26,28) PHSHGZGTOPKZOO-UHFFFAOYSA-N 369102 N-(cyclopropylmethyl)-3-fluoro-4-[6-(4- fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]benzenesulfonamide::US10227357, Compound P-0369 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369102 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369102&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114858 402365900 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729289 Fc1ccc(cc1)-c1cc2c(ncnc2[nH]1)-c1cccnc1C(F)(F)F InChI=1S/C18H10F4N4/c19-11-5-3-10(4-6-11)14-8-13-15(24-9-25-17(13)26-14)12-2-1-7-23-16(12)18(20,21)22/h1-9H,(H,24,25,26) PZGKTNUYJUVNDO-UHFFFAOYSA-N 369103 6-(4-fluorophenyl)-4-[2-(trifluoromethyl)- 3-pyridyl]-7H-pyrrolo[2,3-d]pyrimidine::US10227357, Compound P-0374 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369103 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369103&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114475 402365901 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729290 CS(=O)(=O)Nc1ccccc1-c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 InChI=1S/C19H15FN4O2S/c1-27(25,26)24-16-5-3-2-4-14(16)18-15-10-17(23-19(15)22-11-21-18)12-6-8-13(20)9-7-12/h2-11,24H,1H3,(H,21,22,23) VETZZBSDORVKTN-UHFFFAOYSA-N 369104 N-[2-[6-(4-fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4- yl]phenyl]methanesulfonamide::US10227357, Compound P-0375 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369104 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369104&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114541 402365902 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729291 NS(=O)(=O)c1ccc(c(F)c1)-c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 InChI=1S/C18H12F2N4O2S/c19-11-3-1-10(2-4-11)16-8-14-17(22-9-23-18(14)24-16)13-6-5-12(7-15(13)20)27(21,25)26/h1-9H,(H2,21,25,26)(H,22,23,24) QFRQHOZASOCDDS-UHFFFAOYSA-N 369105 3-fluoro-4-[6-(4-fluorophenyl)-7H- pyrrolo[2,3-d]pyrimidin-4- yl]benzenesulfonamide::US10227357, Compound P-0376 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369105 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369105&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114569 402365903 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729292 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)C2CC2)cc1 InChI=1S/C16H16N4O2S/c1-10-8-14-15(17-9-18-16(14)19-10)11-2-4-12(5-3-11)20-23(21,22)13-6-7-13/h2-5,8-9,13,20H,6-7H2,1H3,(H,17,18,19) KXVLZQBNDHOEHA-UHFFFAOYSA-N 369106 N-[4-(6-methyl-7H-pyrrolo[2,3- d]pyrimidin-4- yl)phenyl]cyclopropanesulfonamide::US10227357, Compound P-0377 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369106 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369106&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114801 402365904 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729293 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(C)(=O)=O)cc1 InChI=1S/C14H14N4O2S/c1-9-7-12-13(15-8-16-14(12)17-9)10-3-5-11(6-4-10)18-21(2,19)20/h3-8,18H,1-2H3,(H,15,16,17) DEDIEMDFAWHGNI-UHFFFAOYSA-N 369107 N-[4-(6-methyl-7H-pyrrolo[2,3- d]pyrimidin-4- yl)phenyl]methanesulfonamide::US10227357, Compound P-0379 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369107 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369107&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115512 402365905 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729294 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(C)(=O)=O)cc1 InChI=1S/C14H14N4O2S/c1-9-7-12-13(15-8-16-14(12)17-9)10-3-5-11(6-4-10)18-21(2,19)20/h3-8,18H,1-2H3,(H,15,16,17) DEDIEMDFAWHGNI-UHFFFAOYSA-N 369107 N-[4-(6-methyl-7H-pyrrolo[2,3- d]pyrimidin-4- yl)phenyl]methanesulfonamide::US10227357, Compound P-0379 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369107 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369107&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115512 402365905 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729295 Cc1cc2c(ncnc2[nH]1)-c1ccc(cc1)S(=O)(=O)NC1CC1 InChI=1S/C16H16N4O2S/c1-10-8-14-15(17-9-18-16(14)19-10)11-2-6-13(7-3-11)23(21,22)20-12-4-5-12/h2-3,6-9,12,20H,4-5H2,1H3,(H,17,18,19) GDTFCSJSOLEZAI-UHFFFAOYSA-N 369108 N-cyclopropyl-4-(6-methyl-7H- pyrrolo[2,3-d]pyrimidin-4- yl)benzenesulfonamide::US10227357, Compound P-0380 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369108 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369108&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114409 402365906 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729296 CCS(=O)(=O)Nc1ccc(c(F)c1)-c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 InChI=1S/C20H16F2N4O2S/c1-2-29(27,28)26-14-7-8-15(17(22)9-14)19-16-10-18(25-20(16)24-11-23-19)12-3-5-13(21)6-4-12/h3-11,26H,2H2,1H3,(H,23,24,25) APRWZENWUFMKIB-UHFFFAOYSA-N 369109 N-[3-fluoro-4-[6-(4-fluorophenyl)-7H- pyrrolo[2,3-d]pyrimidin-4- yl]phenyl]ethanesulfonamide::US10227357, Compound P-0381 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369109 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369109&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114407 402365907 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729297 CCS(=O)(=O)Nc1ccc(c(F)c1)-c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 InChI=1S/C20H16F2N4O2S/c1-2-29(27,28)26-14-7-8-15(17(22)9-14)19-16-10-18(25-20(16)24-11-23-19)12-3-5-13(21)6-4-12/h3-11,26H,2H2,1H3,(H,23,24,25) APRWZENWUFMKIB-UHFFFAOYSA-N 369109 N-[3-fluoro-4-[6-(4-fluorophenyl)-7H- pyrrolo[2,3-d]pyrimidin-4- yl]phenyl]ethanesulfonamide::US10227357, Compound P-0381 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369109 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369109&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114407 402365907 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729298 CS(=O)(=O)Nc1ccc(-c2cc3c(ncnc3[nH]2)-c2ccc(NS(C)(=O)=O)cc2F)c(F)c1 InChI=1S/C20H17F2N5O4S2/c1-32(28,29)26-11-3-5-13(16(21)7-11)18-9-15-19(23-10-24-20(15)25-18)14-6-4-12(8-17(14)22)27-33(2,30)31/h3-10,26-27H,1-2H3,(H,23,24,25) LTJSOLGZFLQJEK-UHFFFAOYSA-N 369110 N-[3-fluoro-4-[4-[2-fluoro-4- (methanesulfonamido)phenyl]-7H- pyrrolo[2,3-d]pyrimidin-6- yl]phenyl]methanesulfonamide::US10227357, Compound P-0382 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369110 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369110&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115027 402365908 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729299 CS(=O)(=O)Nc1ccc(-c2cc3c(ncnc3[nH]2)-c2ccc(NS(C)(=O)=O)cc2F)c(F)c1 InChI=1S/C20H17F2N5O4S2/c1-32(28,29)26-11-3-5-13(16(21)7-11)18-9-15-19(23-10-24-20(15)25-18)14-6-4-12(8-17(14)22)27-33(2,30)31/h3-10,26-27H,1-2H3,(H,23,24,25) LTJSOLGZFLQJEK-UHFFFAOYSA-N 369110 N-[3-fluoro-4-[4-[2-fluoro-4- (methanesulfonamido)phenyl]-7H- pyrrolo[2,3-d]pyrimidin-6- yl]phenyl]methanesulfonamide::US10227357, Compound P-0382 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369110 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369110&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115027 402365908 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729300 O=S(=O)(Nc1cccc(c1)-c1ncnc2[nH]c(cc12)-c1cnc(nc1)C1CC1)C1CC1 InChI=1S/C22H20N6O2S/c29-31(30,17-6-7-17)28-16-3-1-2-14(8-16)20-18-9-19(27-22(18)26-12-25-20)15-10-23-21(24-11-15)13-4-5-13/h1-3,8-13,17,28H,4-7H2,(H,25,26,27) MBWILZHTDUVTJF-UHFFFAOYSA-N 369111 N-[3-[6-(2-cyclopropylpyrimidin-5-yl)-7H- pyrrolo[2,3-d]pyrimidin-4- yl]phenyl]cyclopropanesulfonamide::US10227357, Compound P-0383 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369111 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369111&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115105 402365909 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729301 C1CC1c1ncc(cn1)-c1cc2c(ncnc2[nH]1)-c1cnc(nc1)C1CC1 InChI=1S/C20H17N7/c1-2-11(1)18-21-6-13(7-22-18)16-5-15-17(25-10-26-20(15)27-16)14-8-23-19(24-9-14)12-3-4-12/h5-12H,1-4H2,(H,25,26,27) YHLKYJXHXPKFPN-UHFFFAOYSA-N 369112 4,6-bis(2-cyclopropylpyrimidin-5-yl)-7H- pyrrolo[2,3-d]pyrimidine::US10227357, Compound P-0384 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369112 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369112&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115448 402365910 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729302 NS(=O)(=O)c1ccc(cc1)-c1ncnc2[nH]c(cc12)-c1cnc(nc1)C1CC1 InChI=1S/C19H16N6O2S/c20-28(26,27)14-5-3-11(4-6-14)17-15-7-16(25-19(15)24-10-23-17)13-8-21-18(22-9-13)12-1-2-12/h3-10,12H,1-2H2,(H2,20,26,27)(H,23,24,25) FERBPICFBRERKJ-UHFFFAOYSA-N 369113 4-[6-(2-cyclopropylpyrimidin-5-yl)-7H- pyrrolo[2,3-d]pyrimidin-4- yl]benzenesulfonamide::US10227357, Compound P-0385 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369113 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369113&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114555 402365911 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729303 Fc1cc(NSC2CC2)ccc1-c1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)C2CC2)cc1F InChI=1S/C24H21F2N5O2S2/c25-20-9-13(30-34-15-3-4-15)1-7-17(20)22-11-19-23(27-12-28-24(19)29-22)18-8-2-14(10-21(18)26)31-35(32,33)16-5-6-16/h1-2,7-12,15-16,30-31H,3-6H2,(H,27,28,29) CBPIBBMMZAHUNY-UHFFFAOYSA-N 369114 N-[4-[4-[4-(cyclopropylsulfonylamino)-2- fluoro-phenyl]-7H-pyrrolo[2,3- d]pyrimidin-6-yl]-3-fluoro- phenyl]cyclopropanesulfonamide::US10227357, Compound P-0387 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369114 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369114&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90135116 402365912 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729304 Fc1cc(NSC2CC2)ccc1-c1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)C2CC2)cc1F InChI=1S/C24H21F2N5O2S2/c25-20-9-13(30-34-15-3-4-15)1-7-17(20)22-11-19-23(27-12-28-24(19)29-22)18-8-2-14(10-21(18)26)31-35(32,33)16-5-6-16/h1-2,7-12,15-16,30-31H,3-6H2,(H,27,28,29) CBPIBBMMZAHUNY-UHFFFAOYSA-N 369114 N-[4-[4-[4-(cyclopropylsulfonylamino)-2- fluoro-phenyl]-7H-pyrrolo[2,3- d]pyrimidin-6-yl]-3-fluoro- phenyl]cyclopropanesulfonamide::US10227357, Compound P-0387 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369114 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369114&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90135116 402365912 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729305 CCCCS(=O)(=O)Nc1ccc(cc1)-c1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)CCCC)cc1 InChI=1S/C26H31N5O4S2/c1-3-5-15-36(32,33)30-21-11-7-19(8-12-21)24-17-23-25(27-18-28-26(23)29-24)20-9-13-22(14-10-20)31-37(34,35)16-6-4-2/h7-14,17-18,30-31H,3-6,15-16H2,1-2H3,(H,27,28,29) QIBCSGMNAFIZRM-UHFFFAOYSA-N 369115 N-[4-[4-[4-(butylsulfonylamino)phenyl]- 7H-pyrrolo[2,3-d]pyrimidin-6- yl]phenyl]butane-1-sulfonamide::US10227357, Compound P-0388 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369115 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369115&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114446 402365913 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729306 CCCCS(=O)(=O)Nc1ccc(cc1)-c1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)CCCC)cc1 InChI=1S/C26H31N5O4S2/c1-3-5-15-36(32,33)30-21-11-7-19(8-12-21)24-17-23-25(27-18-28-26(23)29-24)20-9-13-22(14-10-20)31-37(34,35)16-6-4-2/h7-14,17-18,30-31H,3-6,15-16H2,1-2H3,(H,27,28,29) QIBCSGMNAFIZRM-UHFFFAOYSA-N 369115 N-[4-[4-[4-(butylsulfonylamino)phenyl]- 7H-pyrrolo[2,3-d]pyrimidin-6- yl]phenyl]butane-1-sulfonamide::US10227357, Compound P-0388 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369115 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369115&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114446 402365913 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729307 O=S(=O)(Nc1ccc(cc1)-c1ncnc2[nH]c(cc12)-c1ccc(NSC2CC2)cc1)C1CC1 InChI=1S/C24H23N5O2S2/c30-33(31,20-11-12-20)29-18-7-3-16(4-8-18)23-21-13-22(27-24(21)26-14-25-23)15-1-5-17(6-2-15)28-32-19-9-10-19/h1-8,13-14,19-20,28-29H,9-12H2,(H,25,26,27) RJUFZZZHPSIVFE-UHFFFAOYSA-N 369116 N-[4-[4-[4- (cyclopropylsulfonylamino)phenyl]-7H- pyrrolo[2,3-d]pyrimidin-6- yl]phenyl]cyclopropanesulfonamide::US10227357, Compound P-0389 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369116 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369116&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90135092 402365914 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729308 O=S(=O)(Nc1ccc(cc1)-c1ncnc2[nH]c(cc12)-c1ccc(NSC2CC2)cc1)C1CC1 InChI=1S/C24H23N5O2S2/c30-33(31,20-11-12-20)29-18-7-3-16(4-8-18)23-21-13-22(27-24(21)26-14-25-23)15-1-5-17(6-2-15)28-32-19-9-10-19/h1-8,13-14,19-20,28-29H,9-12H2,(H,25,26,27) RJUFZZZHPSIVFE-UHFFFAOYSA-N 369116 N-[4-[4-[4- (cyclopropylsulfonylamino)phenyl]-7H- pyrrolo[2,3-d]pyrimidin-6- yl]phenyl]cyclopropanesulfonamide::US10227357, Compound P-0389 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369116 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369116&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90135092 402365914 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729309 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2ccc(C)cc2)cc1 InChI=1S/C20H18N4O2S/c1-13-3-9-17(10-4-13)27(25,26)24-16-7-5-15(6-8-16)19-18-11-14(2)23-20(18)22-12-21-19/h3-12,24H,1-2H3,(H,21,22,23) VINUGLXKTLMHDL-UHFFFAOYSA-N 369117 4-methyl-N-[4-(6-methyl-7H-pyrrolo[2,3- d]pyrimidin-4- yl)phenyl]benzenesulfonamide::US10227357, Compound P-0390 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369117 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369117&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114430 402365915 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729310 Cc1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2ccc(C)cc2)cc1 InChI=1S/C20H18N4O2S/c1-13-3-9-17(10-4-13)27(25,26)24-16-7-5-15(6-8-16)19-18-11-14(2)23-20(18)22-12-21-19/h3-12,24H,1-2H3,(H,21,22,23) VINUGLXKTLMHDL-UHFFFAOYSA-N 369117 4-methyl-N-[4-(6-methyl-7H-pyrrolo[2,3- d]pyrimidin-4- yl)phenyl]benzenesulfonamide::US10227357, Compound P-0390 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369117 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369117&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114430 402365915 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729311 CS(=O)(=O)c1ccc(cc1)-c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 InChI=1S/C19H14FN3O2S/c1-26(24,25)15-8-4-13(5-9-15)18-16-10-17(23-19(16)22-11-21-18)12-2-6-14(20)7-3-12/h2-11H,1H3,(H,21,22,23) DEAADVZOCAZTLW-UHFFFAOYSA-N 369118 6-(4-fluorophenyl)-4-(4- methylsulfonylphenyl)-7H-pyrrolo[2,3- d]pyrimidine::US10227357, Compound P-0391 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369118&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114189 402365916 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729312 Fc1ccc(cc1)-c1cc2c(ncnc2[nH]1)-c1ccncc1 InChI=1S/C17H11FN4/c18-13-3-1-11(2-4-13)15-9-14-16(12-5-7-19-8-6-12)20-10-21-17(14)22-15/h1-10H,(H,20,21,22) ZWLDVJTYIHILKX-UHFFFAOYSA-N 369119 6-(4-fluorophenyl)-4-(4-pyridyl)-7H- pyrrolo[2,3-d]pyrimidine::US10227357, Compound P-0392 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369119 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369119&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114042 402365917 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729313 Fc1ccc(cc1)-c1cc2c(ncnc2[nH]1)-c1ccc(F)cc1 InChI=1S/C18H11F2N3/c19-13-5-1-11(2-6-13)16-9-15-17(21-10-22-18(15)23-16)12-3-7-14(20)8-4-12/h1-10H,(H,21,22,23) VKJJKRDKOKFMQY-UHFFFAOYSA-N 369120 4,6-bis(4-fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidine::US10227357, Compound P-0395 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369120 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369120&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114095 402365918 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729314 Fc1ccc(cc1)-c1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2ccc(Cl)cc2)cc1F InChI=1S/C24H15ClF2N4O2S/c25-15-3-8-18(9-4-15)34(32,33)31-17-7-10-19(21(27)11-17)23-20-12-22(30-24(20)29-13-28-23)14-1-5-16(26)6-2-14/h1-13,31H,(H,28,29,30) DZLUVHKWGKSLHX-UHFFFAOYSA-N 369121 4-chloro-N-[3-fluoro-4-[6-(4- fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4- yl]phenyl]benzenesulfonamide::US10227357, Compound P-0396 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369121&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114861 402365919 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729315 Fc1ccc(cc1)-c1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2ccc(Cl)cc2)cc1F InChI=1S/C24H15ClF2N4O2S/c25-15-3-8-18(9-4-15)34(32,33)31-17-7-10-19(21(27)11-17)23-20-12-22(30-24(20)29-13-28-23)14-1-5-16(26)6-2-14/h1-13,31H,(H,28,29,30) DZLUVHKWGKSLHX-UHFFFAOYSA-N 369121 4-chloro-N-[3-fluoro-4-[6-(4- fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4- yl]phenyl]benzenesulfonamide::US10227357, Compound P-0396 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369121&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114861 402365919 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729316 CCCS(=O)(=O)Nc1ccc(c(F)c1)-c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 InChI=1S/C21H18F2N4O2S/c1-2-9-30(28,29)27-15-7-8-16(18(23)10-15)20-17-11-19(26-21(17)25-12-24-20)13-3-5-14(22)6-4-13/h3-8,10-12,27H,2,9H2,1H3,(H,24,25,26) ANUALJGVOUJDOJ-UHFFFAOYSA-N 369122 N-[3-fluoro-4-[6-(4-fluorophenyl)-7H- pyrrolo[2,3-d]pyrimidin-4- yl]phenyl]propane-1-sulfonamide::US10227357, Compound P-0397 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369122 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369122&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115097 402365920 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729317 CCCS(=O)(=O)Nc1ccc(c(F)c1)-c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 InChI=1S/C21H18F2N4O2S/c1-2-9-30(28,29)27-15-7-8-16(18(23)10-15)20-17-11-19(26-21(17)25-12-24-20)13-3-5-14(22)6-4-13/h3-8,10-12,27H,2,9H2,1H3,(H,24,25,26) ANUALJGVOUJDOJ-UHFFFAOYSA-N 369122 N-[3-fluoro-4-[6-(4-fluorophenyl)-7H- pyrrolo[2,3-d]pyrimidin-4- yl]phenyl]propane-1-sulfonamide::US10227357, Compound P-0397 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369122 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369122&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115097 402365920 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729318 CS(=O)(=O)Nc1ccc(c(F)c1)-c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 InChI=1S/C19H14F2N4O2S/c1-28(26,27)25-13-6-7-14(16(21)8-13)18-15-9-17(24-19(15)23-10-22-18)11-2-4-12(20)5-3-11/h2-10,25H,1H3,(H,22,23,24) OFIMXXXMDAPOSN-UHFFFAOYSA-N 369101 1,1,1-trideuterio-N-[3-fluoro-4-[6-(4- fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4- yl]phenyl]methanesulfonamide::US10227357, Compound P-0368::US10227357, Compound P-0398 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369101 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369101&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114936 402365899 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729319 CS(=O)(=O)Nc1ccc(c(F)c1)-c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 InChI=1S/C19H14F2N4O2S/c1-28(26,27)25-13-6-7-14(16(21)8-13)18-15-9-17(24-19(15)23-10-22-18)11-2-4-12(20)5-3-11/h2-10,25H,1H3,(H,22,23,24) OFIMXXXMDAPOSN-UHFFFAOYSA-N 369101 1,1,1-trideuterio-N-[3-fluoro-4-[6-(4- fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4- yl]phenyl]methanesulfonamide::US10227357, Compound P-0368::US10227357, Compound P-0398 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369101 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369101&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114936 402365899 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729320 CS(=O)(=O)Nc1ccc(cc1F)-c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 InChI=1S/C19H14F2N4O2S/c1-28(26,27)25-16-7-4-12(8-15(16)21)18-14-9-17(24-19(14)23-10-22-18)11-2-5-13(20)6-3-11/h2-10,25H,1H3,(H,22,23,24) DITNDCGKUORJHQ-UHFFFAOYSA-N 369100 1,1,1-trideuterio-N-[2-fluoro-4-[6-(4- fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4- yl]phenyl]methanesulfonamide::US10227357, Compound P-0367::US10227357, Compound P-0399 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369100 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369100&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114845 402365898 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729321 CS(=O)(=O)Nc1ccc(cc1F)-c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 InChI=1S/C19H14F2N4O2S/c1-28(26,27)25-16-7-4-12(8-15(16)21)18-14-9-17(24-19(14)23-10-22-18)11-2-5-13(20)6-3-11/h2-10,25H,1H3,(H,22,23,24) DITNDCGKUORJHQ-UHFFFAOYSA-N 369100 1,1,1-trideuterio-N-[2-fluoro-4-[6-(4- fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4- yl]phenyl]methanesulfonamide::US10227357, Compound P-0367::US10227357, Compound P-0399 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369100 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369100&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114845 402365898 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729322 Fc1ccc(cc1)-c1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)N2CCCC2)cc1F InChI=1S/C22H19F2N5O2S/c23-15-5-3-14(4-6-15)20-12-18-21(25-13-26-22(18)27-20)17-8-7-16(11-19(17)24)28-32(30,31)29-9-1-2-10-29/h3-8,11-13,28H,1-2,9-10H2,(H,25,26,27) KYWAGHNGDMRNSW-UHFFFAOYSA-N 369125 N-[3-fluoro-4-[6-(4-fluorophenyl)-7H- pyrrolo[2,3-d]pyrimidin-4- yl]phenyl]pyrrolidine-1-sulfonamide::US10227357, Compound P-0400 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369125 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369125&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115006 402365921 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729323 Fc1ccc(cc1)-c1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)C2CC2)cc1F InChI=1S/C21H16F2N4O2S/c22-13-3-1-12(2-4-13)19-10-17-20(24-11-25-21(17)26-19)16-8-5-14(9-18(16)23)27-30(28,29)15-6-7-15/h1-5,8-11,15,27H,6-7H2,(H,24,25,26) XCKUJJNOVUYWIJ-UHFFFAOYSA-N 369126 N-[3-fluoro-4-[6-(4-fluorophenyl)-7H- pyrrolo[2,3-d]pyrimidin-4- yl]phenyl]cyclopropanesulfonamide::US10227357, Compound P-0401 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369126 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369126&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114702 402365922 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729324 Fc1ccc(cc1)-c1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)C2CC2)cc1F InChI=1S/C21H16F2N4O2S/c22-13-3-1-12(2-4-13)19-10-17-20(24-11-25-21(17)26-19)16-8-5-14(9-18(16)23)27-30(28,29)15-6-7-15/h1-5,8-11,15,27H,6-7H2,(H,24,25,26) XCKUJJNOVUYWIJ-UHFFFAOYSA-N 369126 N-[3-fluoro-4-[6-(4-fluorophenyl)-7H- pyrrolo[2,3-d]pyrimidin-4- yl]phenyl]cyclopropanesulfonamide::US10227357, Compound P-0401 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369126 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369126&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114702 402365922 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729325 COc1ccc(cc1)S(=O)(=O)Nc1ccc(c(F)c1)-c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 InChI=1S/C25H18F2N4O3S/c1-34-18-7-9-19(10-8-18)35(32,33)31-17-6-11-20(22(27)12-17)24-21-13-23(30-25(21)29-14-28-24)15-2-4-16(26)5-3-15/h2-14,31H,1H3,(H,28,29,30) BEBVSRMGTAHCRT-UHFFFAOYSA-N 369127 N-[3-fluoro-4-[6-(4-fluorophenyl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]phenyl]-4- methoxy-benzenesulfonamide::US10227357, Compound P-0402 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369127 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369127&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115406 402365923 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729326 COc1ccc(cc1)S(=O)(=O)Nc1ccc(c(F)c1)-c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 InChI=1S/C25H18F2N4O3S/c1-34-18-7-9-19(10-8-18)35(32,33)31-17-6-11-20(22(27)12-17)24-21-13-23(30-25(21)29-14-28-24)15-2-4-16(26)5-3-15/h2-14,31H,1H3,(H,28,29,30) BEBVSRMGTAHCRT-UHFFFAOYSA-N 369127 N-[3-fluoro-4-[6-(4-fluorophenyl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]phenyl]-4- methoxy-benzenesulfonamide::US10227357, Compound P-0402 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369127 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369127&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115406 402365923 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729327 CCCS(=O)(=O)Nc1ccc(cc1F)-c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 InChI=1S/C21H18F2N4O2S/c1-2-9-30(28,29)27-18-8-5-14(10-17(18)23)20-16-11-19(26-21(16)25-12-24-20)13-3-6-15(22)7-4-13/h3-8,10-12,27H,2,9H2,1H3,(H,24,25,26) DSIXTCVLEFHZIE-UHFFFAOYSA-N 369128 N-[2-fluoro-4-[6-(4-fluorophenyl)-7H- pyrrolo[2,3-d]pyrimidin-4- yl]phenyl]propane-1-sulfonamide::US10227357, Compound P-0403 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369128 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369128&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115111 402365924 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729328 CCCS(=O)(=O)Nc1ccc(cc1F)-c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 InChI=1S/C21H18F2N4O2S/c1-2-9-30(28,29)27-18-8-5-14(10-17(18)23)20-16-11-19(26-21(16)25-12-24-20)13-3-6-15(22)7-4-13/h3-8,10-12,27H,2,9H2,1H3,(H,24,25,26) DSIXTCVLEFHZIE-UHFFFAOYSA-N 369128 N-[2-fluoro-4-[6-(4-fluorophenyl)-7H- pyrrolo[2,3-d]pyrimidin-4- yl]phenyl]propane-1-sulfonamide::US10227357, Compound P-0403 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369128 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369128&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115111 402365924 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729329 Fc1ccc(cc1)-c1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2ccc(F)cc2)cc1 InChI=1S/C24H16F2N4O2S/c25-17-5-1-15(2-6-17)22-13-21-23(27-14-28-24(21)29-22)16-3-9-19(10-4-16)30-33(31,32)20-11-7-18(26)8-12-20/h1-14,30H,(H,27,28,29) ZLUKYRPBQDXSMA-UHFFFAOYSA-N 369129 4-fluoro-N-[4-[6-(4-fluorophenyl)-7H- pyrrolo[2,3-d]pyrimidin-4- yl]phenyl]benzenesulfonamide::US10227357, Compound P-0404 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369129 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369129&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114870 402365925 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729330 Fc1ccc(cc1)-c1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2ccc(F)cc2)cc1 InChI=1S/C24H16F2N4O2S/c25-17-5-1-15(2-6-17)22-13-21-23(27-14-28-24(21)29-22)16-3-9-19(10-4-16)30-33(31,32)20-11-7-18(26)8-12-20/h1-14,30H,(H,27,28,29) ZLUKYRPBQDXSMA-UHFFFAOYSA-N 369129 4-fluoro-N-[4-[6-(4-fluorophenyl)-7H- pyrrolo[2,3-d]pyrimidin-4- yl]phenyl]benzenesulfonamide::US10227357, Compound P-0404 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369129 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369129&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114870 402365925 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729331 Fc1ccc(cc1)-c1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)N2CCCC2)c(F)c1 InChI=1S/C22H19F2N5O2S/c23-16-6-3-14(4-7-16)20-12-17-21(25-13-26-22(17)27-20)15-5-8-19(18(24)11-15)28-32(30,31)29-9-1-2-10-29/h3-8,11-13,28H,1-2,9-10H2,(H,25,26,27) NZMQMBUGBGOYRU-UHFFFAOYSA-N 369130 N-[2-fluoro-4-[6-(4-fluorophenyl)-7H- pyrrolo[2,3-d]pyrimidin-4- yl]phenyl]pyrrolidine-1-sulfonamide::US10227357, Compound P-0405 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369130 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369130&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114721 402365926 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729332 CCS(=O)(=O)Nc1cccc(c1)-c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 InChI=1S/C20H17FN4O2S/c1-2-28(26,27)25-16-5-3-4-14(10-16)19-17-11-18(24-20(17)23-12-22-19)13-6-8-15(21)9-7-13/h3-12,25H,2H2,1H3,(H,22,23,24) YGPRYKYNWZZGCR-UHFFFAOYSA-N 369131 N-[3-[6-(4-fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4- yl]phenyl]ethanesulfonamide::US10227357, Compound P-0407 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369131 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369131&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114843 402365927 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729333 CCS(=O)(=O)Nc1cccc(c1)-c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 InChI=1S/C20H17FN4O2S/c1-2-28(26,27)25-16-5-3-4-14(10-16)19-17-11-18(24-20(17)23-12-22-19)13-6-8-15(21)9-7-13/h3-12,25H,2H2,1H3,(H,22,23,24) YGPRYKYNWZZGCR-UHFFFAOYSA-N 369131 N-[3-[6-(4-fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4- yl]phenyl]ethanesulfonamide::US10227357, Compound P-0407 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369131 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369131&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114843 402365927 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729334 Fc1ccc(cc1)-c1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2ccc(F)cc2)c(F)c1 InChI=1S/C24H15F3N4O2S/c25-16-4-1-14(2-5-16)22-12-19-23(28-13-29-24(19)30-22)15-3-10-21(20(27)11-15)31-34(32,33)18-8-6-17(26)7-9-18/h1-13,31H,(H,28,29,30) FPHIKLRHKTZWPF-UHFFFAOYSA-N 369132 4-fluoro-N-[2-fluoro-4-[6-(4- fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4- yl]phenyl]benzenesulfonamide::US10227357, Compound P-0408 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369132 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369132&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115050 402365928 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729335 Fc1ccc(cc1)-c1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2ccc(F)cc2)c(F)c1 InChI=1S/C24H15F3N4O2S/c25-16-4-1-14(2-5-16)22-12-19-23(28-13-29-24(19)30-22)15-3-10-21(20(27)11-15)31-34(32,33)18-8-6-17(26)7-9-18/h1-13,31H,(H,28,29,30) FPHIKLRHKTZWPF-UHFFFAOYSA-N 369132 4-fluoro-N-[2-fluoro-4-[6-(4- fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4- yl]phenyl]benzenesulfonamide::US10227357, Compound P-0408 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369132 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369132&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115050 402365928 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729336 COc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1F)-c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 InChI=1S/C25H18F2N4O3S/c1-34-18-7-9-19(10-8-18)35(32,33)31-22-11-4-16(12-21(22)27)24-20-13-23(30-25(20)29-14-28-24)15-2-5-17(26)6-3-15/h2-14,31H,1H3,(H,28,29,30) JGORNSPJQQQUIN-UHFFFAOYSA-N 369133 N-[2-fluoro-4-[6-(4-fluorophenyl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]phenyl]-4- methoxy-benzenesulfonamide::US10227357, Compound P-0409 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369133 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369133&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115314 402365929 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729337 COc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1F)-c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 InChI=1S/C25H18F2N4O3S/c1-34-18-7-9-19(10-8-18)35(32,33)31-22-11-4-16(12-21(22)27)24-20-13-23(30-25(20)29-14-28-24)15-2-5-17(26)6-3-15/h2-14,31H,1H3,(H,28,29,30) JGORNSPJQQQUIN-UHFFFAOYSA-N 369133 N-[2-fluoro-4-[6-(4-fluorophenyl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]phenyl]-4- methoxy-benzenesulfonamide::US10227357, Compound P-0409 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369133 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369133&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115314 402365929 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729338 Fc1ccc(cc1)-c1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)C2CC2)c(F)c1 InChI=1S/C21H16F2N4O2S/c22-14-4-1-12(2-5-14)19-10-16-20(24-11-25-21(16)26-19)13-3-8-18(17(23)9-13)27-30(28,29)15-6-7-15/h1-5,8-11,15,27H,6-7H2,(H,24,25,26) ZXRHEUVLFCTZEW-UHFFFAOYSA-N 369134 N-[2-fluoro-4-[6-(4-fluorophenyl)-7H- pyrrolo[2,3-d]pyrimidin-4- yl]phenyl]cyclopropanesulfonamide::US10227357, Compound P-0410 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369134 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369134&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115190 402365930 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729339 Fc1ccc(cc1)-c1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)C2CC2)c(F)c1 InChI=1S/C21H16F2N4O2S/c22-14-4-1-12(2-5-14)19-10-16-20(24-11-25-21(16)26-19)13-3-8-18(17(23)9-13)27-30(28,29)15-6-7-15/h1-5,8-11,15,27H,6-7H2,(H,24,25,26) ZXRHEUVLFCTZEW-UHFFFAOYSA-N 369134 N-[2-fluoro-4-[6-(4-fluorophenyl)-7H- pyrrolo[2,3-d]pyrimidin-4- yl]phenyl]cyclopropanesulfonamide::US10227357, Compound P-0410 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369134 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369134&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115190 402365930 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729340 Fc1ccc(cc1)-c1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)N2CCCC2)cc1 InChI=1S/C22H20FN5O2S/c23-17-7-3-15(4-8-17)20-13-19-21(24-14-25-22(19)26-20)16-5-9-18(10-6-16)27-31(29,30)28-11-1-2-12-28/h3-10,13-14,27H,1-2,11-12H2,(H,24,25,26) XZYRZRLRQVJYAF-UHFFFAOYSA-N 369135 N-[4-[6-(4-fluorophenyl)-7H- pyrrolo[2,3-d]pyrimidin-4- yl]phenyl]pyrrolidine-1-sulfonamide::US10227357, Compound P-0411 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369135 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369135&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115103 402365931 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729341 Fc1ccc(cc1)-c1cc2c(ncnc2[nH]1)-c1cccc(NS(=O)(=O)C2CC2)c1 InChI=1S/C21H17FN4O2S/c22-15-6-4-13(5-7-15)19-11-18-20(23-12-24-21(18)25-19)14-2-1-3-16(10-14)26-29(27,28)17-8-9-17/h1-7,10-12,17,26H,8-9H2,(H,23,24,25) RDASGUVLNWZPGU-UHFFFAOYSA-N 369136 N-[3-[6-(4-fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4- yl]phenyl]cyclopropanesulfonamide::US10227357, Compound P-0413 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369136 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369136&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115520 402365932 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729342 Fc1ccc(cc1)-c1cc2c(ncnc2[nH]1)-c1cccc(NS(=O)(=O)C2CC2)c1 InChI=1S/C21H17FN4O2S/c22-15-6-4-13(5-7-15)19-11-18-20(23-12-24-21(18)25-19)14-2-1-3-16(10-14)26-29(27,28)17-8-9-17/h1-7,10-12,17,26H,8-9H2,(H,23,24,25) RDASGUVLNWZPGU-UHFFFAOYSA-N 369136 N-[3-[6-(4-fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4- yl]phenyl]cyclopropanesulfonamide::US10227357, Compound P-0413 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369136 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369136&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115520 402365932 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729343 CS(=O)(=O)Nc1cccc(c1)-c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 InChI=1S/C19H15FN4O2S/c1-27(25,26)24-15-4-2-3-13(9-15)18-16-10-17(23-19(16)22-11-21-18)12-5-7-14(20)8-6-12/h2-11,24H,1H3,(H,21,22,23) JOSIWNKVNQHRJW-UHFFFAOYSA-N 369137 N-[3-[6-(4-fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4- yl]phenyl]methanesulfonamide::US10227357, Compound P-0414 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369137 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369137&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114852 402365933 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729344 CS(=O)(=O)Nc1cccc(c1)-c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 InChI=1S/C19H15FN4O2S/c1-27(25,26)24-15-4-2-3-13(9-15)18-16-10-17(23-19(16)22-11-21-18)12-5-7-14(20)8-6-12/h2-11,24H,1H3,(H,21,22,23) JOSIWNKVNQHRJW-UHFFFAOYSA-N 369137 N-[3-[6-(4-fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4- yl]phenyl]methanesulfonamide::US10227357, Compound P-0414 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369137 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369137&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114852 402365933 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729345 Fc1ccc(cc1)-c1cc2c(ncnc2[nH]1)-c1ccc(NCc2ccc(nc2)C(F)(F)F)nc1 InChI=1S/C24H16F4N6/c25-17-5-2-15(3-6-17)19-9-18-22(32-13-33-23(18)34-19)16-4-8-21(31-12-16)30-11-14-1-7-20(29-10-14)24(26,27)28/h1-10,12-13H,11H2,(H,30,31)(H,32,33,34) HSXNHGMTBLVGTJ-UHFFFAOYSA-N 369138 5-[6-(4-fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[[6-(trifluoromethyl)- 3-pyridyl]methyl]pyridin-2-amine::US10227357, Compound P-0415 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369138 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369138&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114037 402365934 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729346 Fc1ccc(cc1)-c1cc2c(ncnc2[nH]1)-c1ccc(NCc2ccc(nc2)C(F)(F)F)nc1 InChI=1S/C24H16F4N6/c25-17-5-2-15(3-6-17)19-9-18-22(32-13-33-23(18)34-19)16-4-8-21(31-12-16)30-11-14-1-7-20(29-10-14)24(26,27)28/h1-10,12-13H,11H2,(H,30,31)(H,32,33,34) HSXNHGMTBLVGTJ-UHFFFAOYSA-N 369138 5-[6-(4-fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[[6-(trifluoromethyl)- 3-pyridyl]methyl]pyridin-2-amine::US10227357, Compound P-0415 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369138 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369138&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114037 402365934 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729347 Nc1ccc(cc1)-c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 InChI=1S/C18H13FN4/c19-13-5-1-11(2-6-13)16-9-15-17(21-10-22-18(15)23-16)12-3-7-14(20)8-4-12/h1-10H,20H2,(H,21,22,23) JYSOPVJXKNFNPI-UHFFFAOYSA-N 369139 4-[6-(4-fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]aniline::US10227357, Compound P-0416 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369139 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369139&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114382 402365935 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729348 Nc1ccc(cc1)-c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 InChI=1S/C18H13FN4/c19-13-5-1-11(2-6-13)16-9-15-17(21-10-22-18(15)23-16)12-3-7-14(20)8-4-12/h1-10H,20H2,(H,21,22,23) JYSOPVJXKNFNPI-UHFFFAOYSA-N 369139 4-[6-(4-fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]aniline::US10227357, Compound P-0416 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369139 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369139&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114382 402365935 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729349 CCNc1ccc(cn1)-c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 InChI=1S/C19H16FN5/c1-2-21-17-8-5-13(10-22-17)18-15-9-16(25-19(15)24-11-23-18)12-3-6-14(20)7-4-12/h3-11H,2H2,1H3,(H,21,22)(H,23,24,25) GAYDJIYNSPXAMP-UHFFFAOYSA-N 369140 N-ethyl-5-[6-(4-fluorophenyl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]pyridin-2- amine::US10227357, Compound P-0417 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369140 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369140&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115317 402365936 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729350 NS(=O)(=O)c1ccc(cc1)-c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 InChI=1S/C18H13FN4O2S/c19-13-5-1-11(2-6-13)16-9-15-17(21-10-22-18(15)23-16)12-3-7-14(8-4-12)26(20,24)25/h1-10H,(H2,20,24,25)(H,21,22,23) IOYGNRPOROYKIJ-UHFFFAOYSA-N 369141 4-[6-(4-fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]benzenesulfonamide::US10227357, Compound P-0418 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369141 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369141&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114920 402365937 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729351 NS(=O)(=O)c1ccc(cc1)-c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 InChI=1S/C18H13FN4O2S/c19-13-5-1-11(2-6-13)16-9-15-17(21-10-22-18(15)23-16)12-3-7-14(8-4-12)26(20,24)25/h1-10H,(H2,20,24,25)(H,21,22,23) IOYGNRPOROYKIJ-UHFFFAOYSA-N 369141 4-[6-(4-fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]benzenesulfonamide::US10227357, Compound P-0418 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369141 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369141&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114920 402365937 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729352 CCCCS(=O)(=O)Nc1ccc(cc1)-c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 InChI=1S/C22H21FN4O2S/c1-2-3-12-30(28,29)27-18-10-6-16(7-11-18)21-19-13-20(26-22(19)25-14-24-21)15-4-8-17(23)9-5-15/h4-11,13-14,27H,2-3,12H2,1H3,(H,24,25,26) CECRJIIYQYYLIH-UHFFFAOYSA-N 369142 N-[4-[6-(4-fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]phenyl]butane-1- sulfonamide::US10227357, Compound P-0419 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369142 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369142&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114640 402365938 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729353 CCCCS(=O)(=O)Nc1ccc(cc1)-c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 InChI=1S/C22H21FN4O2S/c1-2-3-12-30(28,29)27-18-10-6-16(7-11-18)21-19-13-20(26-22(19)25-14-24-21)15-4-8-17(23)9-5-15/h4-11,13-14,27H,2-3,12H2,1H3,(H,24,25,26) CECRJIIYQYYLIH-UHFFFAOYSA-N 369142 N-[4-[6-(4-fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]phenyl]butane-1- sulfonamide::US10227357, Compound P-0419 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369142 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369142&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114640 402365938 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729354 Fc1ccc(cc1)-c1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)C2CC2)cc1 InChI=1S/C21H17FN4O2S/c22-15-5-1-13(2-6-15)19-11-18-20(23-12-24-21(18)25-19)14-3-7-16(8-4-14)26-29(27,28)17-9-10-17/h1-8,11-12,17,26H,9-10H2,(H,23,24,25) CADSCDOGMAWTRX-UHFFFAOYSA-N 369143 N-[4-[6-(4-fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4- yl]phenyl]cyclopropanesulfonamide::US10227357, Compound P-0420 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369143 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369143&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115285 402365939 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729355 Fc1ccc(cc1)-c1cc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)C2CC2)cc1 InChI=1S/C21H17FN4O2S/c22-15-5-1-13(2-6-15)19-11-18-20(23-12-24-21(18)25-19)14-3-7-16(8-4-14)26-29(27,28)17-9-10-17/h1-8,11-12,17,26H,9-10H2,(H,23,24,25) CADSCDOGMAWTRX-UHFFFAOYSA-N 369143 N-[4-[6-(4-fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4- yl]phenyl]cyclopropanesulfonamide::US10227357, Compound P-0420 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369143 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369143&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115285 402365939 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729356 CCCCNS(=O)(=O)c1ccc(cc1)-c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 InChI=1S/C22H21FN4O2S/c1-2-3-12-26-30(28,29)18-10-6-16(7-11-18)21-19-13-20(27-22(19)25-14-24-21)15-4-8-17(23)9-5-15/h4-11,13-14,26H,2-3,12H2,1H3,(H,24,25,27) TZRAXUKCGJMTSH-UHFFFAOYSA-N 369144 N-butyl-4-[6-(4-fluorophenyl)-7H- pyrrolo[2,3-d]pyrimidin-4- yl]benzenesulfonamide::US10227357, Compound P-0421 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369144 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369144&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115008 402365940 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729357 CCNS(=O)(=O)c1ccc(cc1)-c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 InChI=1S/C20H17FN4O2S/c1-2-24-28(26,27)16-9-5-14(6-10-16)19-17-11-18(25-20(17)23-12-22-19)13-3-7-15(21)8-4-13/h3-12,24H,2H2,1H3,(H,22,23,25) PENSFSCIHKCAED-UHFFFAOYSA-N 369145 N-ethyl-4-[6-(4-fluorophenyl)-7H- pyrrolo[2,3-d]pyrimidin-4- yl]benzenesulfonamide::US10227357, Compound P-0422 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369145 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369145&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114081 402365941 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729358 COc1ccc(CNS(=O)(=O)c2ccc(cc2)-c2ncnc3[nH]c(cc23)-c2ccc(F)cc2)cc1 InChI=1S/C26H21FN4O3S/c1-34-21-10-2-17(3-11-21)15-30-35(32,33)22-12-6-19(7-13-22)25-23-14-24(31-26(23)29-16-28-25)18-4-8-20(27)9-5-18/h2-14,16,30H,15H2,1H3,(H,28,29,31) PDKMXBZALVIFKL-UHFFFAOYSA-N 369146 4-[6-(4-fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[(4- methoxyphenyl)methyl]benzenesulfonamide::US10227357, Compound P-0423 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369146 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369146&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114808 402365942 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729359 COc1ccc(CNS(=O)(=O)c2ccc(cc2)-c2ncnc3[nH]c(cc23)-c2ccc(F)cc2)cc1 InChI=1S/C26H21FN4O3S/c1-34-21-10-2-17(3-11-21)15-30-35(32,33)22-12-6-19(7-13-22)25-23-14-24(31-26(23)29-16-28-25)18-4-8-20(27)9-5-18/h2-14,16,30H,15H2,1H3,(H,28,29,31) PDKMXBZALVIFKL-UHFFFAOYSA-N 369146 4-[6-(4-fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[(4- methoxyphenyl)methyl]benzenesulfonamide::US10227357, Compound P-0423 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369146 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369146&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114808 402365942 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729360 Cc1ccc(NS(=O)(=O)c2ccc(cc2)-c2ncnc3[nH]c(cc23)-c2ccc(F)cc2)cc1 InChI=1S/C25H19FN4O2S/c1-16-2-10-20(11-3-16)30-33(31,32)21-12-6-18(7-13-21)24-22-14-23(29-25(22)28-15-27-24)17-4-8-19(26)9-5-17/h2-15,30H,1H3,(H,27,28,29) CGIFXKITZCBZPE-UHFFFAOYSA-N 369147 4-[6-(4-fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-(p- tolyl)benzenesulfonamide::US10227357, Compound P-0426 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369147 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369147&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114828 402365943 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729361 Cc1ccc(NS(=O)(=O)c2ccc(cc2)-c2ncnc3[nH]c(cc23)-c2ccc(F)cc2)cc1 InChI=1S/C25H19FN4O2S/c1-16-2-10-20(11-3-16)30-33(31,32)21-12-6-18(7-13-21)24-22-14-23(29-25(22)28-15-27-24)17-4-8-19(26)9-5-17/h2-15,30H,1H3,(H,27,28,29) CGIFXKITZCBZPE-UHFFFAOYSA-N 369147 4-[6-(4-fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-(p- tolyl)benzenesulfonamide::US10227357, Compound P-0426 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369147 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369147&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114828 402365943 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729362 Fc1ccc(NS(=O)(=O)c2ccc(cc2)-c2ncnc3[nH]c(cc23)-c2ccc(F)cc2)cc1 InChI=1S/C24H16F2N4O2S/c25-17-5-1-15(2-6-17)22-13-21-23(27-14-28-24(21)29-22)16-3-11-20(12-4-16)33(31,32)30-19-9-7-18(26)8-10-19/h1-14,30H,(H,27,28,29) IGPBOWDRIRHCRW-UHFFFAOYSA-N 369148 N-(4-fluorophenyl)-4-[6-(4-fluorophenyl)- 7H-pyrrolo[2,3-d]pyrimidin-4- yl]benzenesulfonamide::US10227357, Compound P-0428 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369148 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369148&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114863 402365944 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729363 Fc1ccc(cc1)-c1cc2c(ncnc2[nH]1)-c1cccc(c1)S(=O)(=O)NC1CC1 InChI=1S/C21H17FN4O2S/c22-15-6-4-13(5-7-15)19-11-18-20(23-12-24-21(18)25-19)14-2-1-3-17(10-14)29(27,28)26-16-8-9-16/h1-7,10-12,16,26H,8-9H2,(H,23,24,25) MFVBWIAKQUNTKU-UHFFFAOYSA-N 369149 N-cyclopropyl-3-[6-(4-fluorophenyl)-7H- pyrrolo[2,3-d]pyrimidin-4- yl]benzenesulfonamide::US10227357, Compound P-0429 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369149 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369149&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114832 402365945 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729364 Fc1ccc(cc1)-c1cc2c(ncnc2[nH]1)-c1cccc(c1)S(=O)(=O)NC1CC1 InChI=1S/C21H17FN4O2S/c22-15-6-4-13(5-7-15)19-11-18-20(23-12-24-21(18)25-19)14-2-1-3-17(10-14)29(27,28)26-16-8-9-16/h1-7,10-12,16,26H,8-9H2,(H,23,24,25) MFVBWIAKQUNTKU-UHFFFAOYSA-N 369149 N-cyclopropyl-3-[6-(4-fluorophenyl)-7H- pyrrolo[2,3-d]pyrimidin-4- yl]benzenesulfonamide::US10227357, Compound P-0429 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369149 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369149&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114832 402365945 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729365 CNS(=O)(=O)c1ccc(cc1)-c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 InChI=1S/C19H15FN4O2S/c1-21-27(25,26)15-8-4-13(5-9-15)18-16-10-17(24-19(16)23-11-22-18)12-2-6-14(20)7-3-12/h2-11,21H,1H3,(H,22,23,24) UYEVYUKGAVJGIF-UHFFFAOYSA-N 369150 4-[6-(4-fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-methyl- benzenesulfonamide::US10227357, Compound P-0430 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369150 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369150&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114239 402365946 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729366 CNS(=O)(=O)c1ccc(cc1)-c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 InChI=1S/C19H15FN4O2S/c1-21-27(25,26)15-8-4-13(5-9-15)18-16-10-17(24-19(16)23-11-22-18)12-2-6-14(20)7-3-12/h2-11,21H,1H3,(H,22,23,24) UYEVYUKGAVJGIF-UHFFFAOYSA-N 369150 4-[6-(4-fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-methyl- benzenesulfonamide::US10227357, Compound P-0430 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369150 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369150&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114239 402365946 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729367 CCS(=O)(=O)Nc1ccc(cc1)-c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 InChI=1S/C20H17FN4O2S/c1-2-28(26,27)25-16-9-5-14(6-10-16)19-17-11-18(24-20(17)23-12-22-19)13-3-7-15(21)8-4-13/h3-12,25H,2H2,1H3,(H,22,23,24) MCLLNPWFOGIYDP-UHFFFAOYSA-N 369151 N-[4-[6-(4-fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4- yl]phenyl]ethanesulfonamide::US10227357, Compound P-0431 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369151 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369151&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115007 402365947 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729368 CCS(=O)(=O)Nc1ccc(cc1)-c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 InChI=1S/C20H17FN4O2S/c1-2-28(26,27)25-16-9-5-14(6-10-16)19-17-11-18(24-20(17)23-12-22-19)13-3-7-15(21)8-4-13/h3-12,25H,2H2,1H3,(H,22,23,24) MCLLNPWFOGIYDP-UHFFFAOYSA-N 369151 N-[4-[6-(4-fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4- yl]phenyl]ethanesulfonamide::US10227357, Compound P-0431 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369151 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369151&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115007 402365947 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729369 CS(=O)(=O)Nc1ccc(cc1)-c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 InChI=1S/C19H15FN4O2S/c1-27(25,26)24-15-8-4-13(5-9-15)18-16-10-17(23-19(16)22-11-21-18)12-2-6-14(20)7-3-12/h2-11,24H,1H3,(H,21,22,23) NWWBCZIIVXDPRI-UHFFFAOYSA-N 369152 N-[4-[6-(4-fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4- yl]phenyl]methanesulfonamide::US10227357, Compound P-0432 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369152 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369152&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114630 402365948 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729370 CS(=O)(=O)Nc1ccc(cc1)-c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 InChI=1S/C19H15FN4O2S/c1-27(25,26)24-15-8-4-13(5-9-15)18-16-10-17(23-19(16)22-11-21-18)12-2-6-14(20)7-3-12/h2-11,24H,1H3,(H,21,22,23) NWWBCZIIVXDPRI-UHFFFAOYSA-N 369152 N-[4-[6-(4-fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4- yl]phenyl]methanesulfonamide::US10227357, Compound P-0432 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369152 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369152&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114630 402365948 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729371 Cc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)-c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 InChI=1S/C25H19FN4O2S/c1-16-2-12-21(13-3-16)33(31,32)30-20-10-6-18(7-11-20)24-22-14-23(29-25(22)28-15-27-24)17-4-8-19(26)9-5-17/h2-15,30H,1H3,(H,27,28,29) HRUOFQSKUVWQBS-UHFFFAOYSA-N 369153 N-[4-[6-(4-fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]phenyl]-4-methyl- benzenesulfonamide::US10227357, Compound P-0433 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369153 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369153&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114856 402365949 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729372 Cc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)-c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 InChI=1S/C25H19FN4O2S/c1-16-2-12-21(13-3-16)33(31,32)30-20-10-6-18(7-11-20)24-22-14-23(29-25(22)28-15-27-24)17-4-8-19(26)9-5-17/h2-15,30H,1H3,(H,27,28,29) HRUOFQSKUVWQBS-UHFFFAOYSA-N 369153 N-[4-[6-(4-fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]phenyl]-4-methyl- benzenesulfonamide::US10227357, Compound P-0433 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369153 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369153&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114856 402365949 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729373 CCCS(=O)(=O)Nc1cccc(c1)-c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 InChI=1S/C21H19FN4O2S/c1-2-10-29(27,28)26-17-5-3-4-15(11-17)20-18-12-19(25-21(18)24-13-23-20)14-6-8-16(22)9-7-14/h3-9,11-13,26H,2,10H2,1H3,(H,23,24,25) ITNJJNQMRKCCLC-UHFFFAOYSA-N 369154 N-[3-[6-(4-fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]phenyl]propane-1- sulfonamide::US10227357, Compound P-0434 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369154 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369154&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114730 402365950 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729374 CCCS(=O)(=O)Nc1cccc(c1)-c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 InChI=1S/C21H19FN4O2S/c1-2-10-29(27,28)26-17-5-3-4-15(11-17)20-18-12-19(25-21(18)24-13-23-20)14-6-8-16(22)9-7-14/h3-9,11-13,26H,2,10H2,1H3,(H,23,24,25) ITNJJNQMRKCCLC-UHFFFAOYSA-N 369154 N-[3-[6-(4-fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]phenyl]propane-1- sulfonamide::US10227357, Compound P-0434 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369154 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369154&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114730 402365950 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729375 Cc1ccc(cc1)S(=O)(=O)Nc1cccc(c1)-c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 InChI=1S/C25H19FN4O2S/c1-16-5-11-21(12-6-16)33(31,32)30-20-4-2-3-18(13-20)24-22-14-23(29-25(22)28-15-27-24)17-7-9-19(26)10-8-17/h2-15,30H,1H3,(H,27,28,29) STVRWRSLRGUZAF-UHFFFAOYSA-N 369155 N-[3-[6-(4-fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]phenyl]-4-methyl- benzenesulfonamide::US10227357, Compound P-0435 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369155 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369155&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114651 402365951 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729376 Cc1n[nH]c2ncnc(-c3ccc(NS(=O)(=O)c4ccc(cc4)C(F)(F)F)cc3)c12 InChI=1S/C19H14F3N5O2S/c1-11-16-17(23-10-24-18(16)26-25-11)12-2-6-14(7-3-12)27-30(28,29)15-8-4-13(5-9-15)19(20,21)22/h2-10,27H,1H3,(H,23,24,25,26) GHRMOFGOCWWIPA-UHFFFAOYSA-N 369156 N-[4-(3-methyl-1H-pyrazolo[3,4- d]pyrimidin-4-yl)phenyl]-4- (trifluoromethyl)benzenesulfonamide::US10227357, Compound P-0438 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369156 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369156&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114744 402365952 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729377 Cc1n[nH]c2ncnc(-c3ccc(NS(=O)(=O)c4ccc(cc4)C(F)(F)F)cc3)c12 InChI=1S/C19H14F3N5O2S/c1-11-16-17(23-10-24-18(16)26-25-11)12-2-6-14(7-3-12)27-30(28,29)15-8-4-13(5-9-15)19(20,21)22/h2-10,27H,1H3,(H,23,24,25,26) GHRMOFGOCWWIPA-UHFFFAOYSA-N 369156 N-[4-(3-methyl-1H-pyrazolo[3,4- d]pyrimidin-4-yl)phenyl]-4- (trifluoromethyl)benzenesulfonamide::US10227357, Compound P-0438 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369156 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369156&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114744 402365952 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729378 Cc1n[nH]c2ncnc(-c3ccc(NS(=O)(=O)c4ccc(F)cc4)cc3)c12 InChI=1S/C18H14FN5O2S/c1-11-16-17(20-10-21-18(16)23-22-11)12-2-6-14(7-3-12)24-27(25,26)15-8-4-13(19)5-9-15/h2-10,24H,1H3,(H,20,21,22,23) XVFZHTIKPMKGHB-UHFFFAOYSA-N 369157 4-fluoro-N-[4-(3-methyl-1H-pyrazolo[3,4- d]pyrimidin-4- yl)phenyl]benzenesulfonamide::US10227357, Compound P-0439 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369157 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369157&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 89993989 402365953 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729379 Cc1n[nH]c2ncnc(-c3ccc(NS(=O)(=O)c4ccc(F)cc4)cc3)c12 InChI=1S/C18H14FN5O2S/c1-11-16-17(20-10-21-18(16)23-22-11)12-2-6-14(7-3-12)24-27(25,26)15-8-4-13(19)5-9-15/h2-10,24H,1H3,(H,20,21,22,23) XVFZHTIKPMKGHB-UHFFFAOYSA-N 369157 4-fluoro-N-[4-(3-methyl-1H-pyrazolo[3,4- d]pyrimidin-4- yl)phenyl]benzenesulfonamide::US10227357, Compound P-0439 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369157 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369157&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 89993989 402365953 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729380 Cc1n[nH]c2ncnc(-c3ccc(NS(=O)(=O)c4cccc(F)c4)cc3)c12 InChI=1S/C18H14FN5O2S/c1-11-16-17(20-10-21-18(16)23-22-11)12-5-7-14(8-6-12)24-27(25,26)15-4-2-3-13(19)9-15/h2-10,24H,1H3,(H,20,21,22,23) WRBFQDBXLFPLLJ-UHFFFAOYSA-N 369158 3-fluoro-N-[4-(3-methyl-1H-pyrazolo[3,4- d]pyrimidin-4- yl)phenyl]benzenesulfonamide::US10227357, Compound P-0440 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369158 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369158&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114471 402365954 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729381 Cc1n[nH]c2ncnc(-c3ccc(NS(=O)(=O)c4cccc(F)c4)cc3)c12 InChI=1S/C18H14FN5O2S/c1-11-16-17(20-10-21-18(16)23-22-11)12-5-7-14(8-6-12)24-27(25,26)15-4-2-3-13(19)9-15/h2-10,24H,1H3,(H,20,21,22,23) WRBFQDBXLFPLLJ-UHFFFAOYSA-N 369158 3-fluoro-N-[4-(3-methyl-1H-pyrazolo[3,4- d]pyrimidin-4- yl)phenyl]benzenesulfonamide::US10227357, Compound P-0440 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369158 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369158&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114471 402365954 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729382 Cc1n[nH]c2ncnc(-c3ccc(NS(=O)(=O)c4ccc(nc4)C(F)(F)F)cc3)c12 InChI=1S/C18H13F3N6O2S/c1-10-15-16(23-9-24-17(15)26-25-10)11-2-4-12(5-3-11)27-30(28,29)13-6-7-14(22-8-13)18(19,20)21/h2-9,27H,1H3,(H,23,24,25,26) PZTKVXIIVZMTTP-UHFFFAOYSA-N 369159 N-[4-(3-methyl-1H-pyrazolo[3,4- d]pyrimidin-4-yl)phenyl]-6- (trifluoromethyl)pyridine-3-sulfonamide::US10227357, Compound P-0441 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369159 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369159&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114887 402365955 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729383 Cc1n[nH]c2ncnc(-c3ccc(NS(=O)(=O)c4ccc(nc4)C(F)(F)F)cc3)c12 InChI=1S/C18H13F3N6O2S/c1-10-15-16(23-9-24-17(15)26-25-10)11-2-4-12(5-3-11)27-30(28,29)13-6-7-14(22-8-13)18(19,20)21/h2-9,27H,1H3,(H,23,24,25,26) PZTKVXIIVZMTTP-UHFFFAOYSA-N 369159 N-[4-(3-methyl-1H-pyrazolo[3,4- d]pyrimidin-4-yl)phenyl]-6- (trifluoromethyl)pyridine-3-sulfonamide::US10227357, Compound P-0441 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369159 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369159&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114887 402365955 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729384 CCc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)-c1ncnc2[nH]nc(C)c12 InChI=1S/C20H19N5O2S/c1-3-14-4-10-17(11-5-14)28(26,27)25-16-8-6-15(7-9-16)19-18-13(2)23-24-20(18)22-12-21-19/h4-12,25H,3H2,1-2H3,(H,21,22,23,24) JWFPWSCTBVJJHO-UHFFFAOYSA-N 369160 4-ethyl-N-[4-(3-methyl-1H-pyrazolo[3,4- d]pyrimidin-4- yl)phenyl]benzenesulfonamide::US10227357, Compound P-0442 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369160 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369160&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114905 402365956 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729385 CCc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)-c1ncnc2[nH]nc(C)c12 InChI=1S/C20H19N5O2S/c1-3-14-4-10-17(11-5-14)28(26,27)25-16-8-6-15(7-9-16)19-18-13(2)23-24-20(18)22-12-21-19/h4-12,25H,3H2,1-2H3,(H,21,22,23,24) JWFPWSCTBVJJHO-UHFFFAOYSA-N 369160 4-ethyl-N-[4-(3-methyl-1H-pyrazolo[3,4- d]pyrimidin-4- yl)phenyl]benzenesulfonamide::US10227357, Compound P-0442 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369160 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369160&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114905 402365956 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729386 Cc1n[nH]c2ncnc(-c3ccc(NS(=O)(=O)c4cccc(Cl)c4)cc3)c12 InChI=1S/C18H14ClN5O2S/c1-11-16-17(20-10-21-18(16)23-22-11)12-5-7-14(8-6-12)24-27(25,26)15-4-2-3-13(19)9-15/h2-10,24H,1H3,(H,20,21,22,23) MCXBMBVZXLVTLR-UHFFFAOYSA-N 369161 3-chloro-N-[4-(3-methyl-1H-pyrazolo[3,4- d]pyrimidin-4- yl)phenyl]benzenesulfonamide::US10227357, Compound P-0443 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369161 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369161&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114230 402365957 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729387 Cc1n[nH]c2ncnc(-c3ccc(NS(=O)(=O)c4cccc(Cl)c4)cc3)c12 InChI=1S/C18H14ClN5O2S/c1-11-16-17(20-10-21-18(16)23-22-11)12-5-7-14(8-6-12)24-27(25,26)15-4-2-3-13(19)9-15/h2-10,24H,1H3,(H,20,21,22,23) MCXBMBVZXLVTLR-UHFFFAOYSA-N 369161 3-chloro-N-[4-(3-methyl-1H-pyrazolo[3,4- d]pyrimidin-4- yl)phenyl]benzenesulfonamide::US10227357, Compound P-0443 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369161 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369161&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114230 402365957 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729388 COc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)-c1ncnc2[nH]nc(C)c12 InChI=1S/C19H17N5O3S/c1-12-17-18(20-11-21-19(17)23-22-12)13-3-5-14(6-4-13)24-28(25,26)16-9-7-15(27-2)8-10-16/h3-11,24H,1-2H3,(H,20,21,22,23) JHOAVJRPUIOBPT-UHFFFAOYSA-N 369162 4-methoxy-N-[4-(3-methyl-1H- pyrazolo[3,4-d]pyrimidin-4- yl)phenyl]benzenesulfonamide::US10227357, Compound P-0444 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369162 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369162&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114542 402365958 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729389 COc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)-c1ncnc2[nH]nc(C)c12 InChI=1S/C19H17N5O3S/c1-12-17-18(20-11-21-19(17)23-22-12)13-3-5-14(6-4-13)24-28(25,26)16-9-7-15(27-2)8-10-16/h3-11,24H,1-2H3,(H,20,21,22,23) JHOAVJRPUIOBPT-UHFFFAOYSA-N 369162 4-methoxy-N-[4-(3-methyl-1H- pyrazolo[3,4-d]pyrimidin-4- yl)phenyl]benzenesulfonamide::US10227357, Compound P-0444 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369162 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369162&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114542 402365958 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729390 Cc1n[nH]c2ncnc(-c3ccc(NS(=O)(=O)c4ccc(Cl)cc4)cc3)c12 InChI=1S/C18H14ClN5O2S/c1-11-16-17(20-10-21-18(16)23-22-11)12-2-6-14(7-3-12)24-27(25,26)15-8-4-13(19)5-9-15/h2-10,24H,1H3,(H,20,21,22,23) AWXNUNSIUAEQEB-UHFFFAOYSA-N 369163 4-chloro-N-[4-(3-methyl-1H-pyrazolo[3,4- d]pyrimidin-4- yl)phenyl]benzenesulfonamide::US10227357, Compound P-0445 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369163 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369163&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114559 402365959 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729391 Cc1n[nH]c2ncnc(-c3ccc(NS(=O)(=O)c4ccc(Cl)cc4)cc3)c12 InChI=1S/C18H14ClN5O2S/c1-11-16-17(20-10-21-18(16)23-22-11)12-2-6-14(7-3-12)24-27(25,26)15-8-4-13(19)5-9-15/h2-10,24H,1H3,(H,20,21,22,23) AWXNUNSIUAEQEB-UHFFFAOYSA-N 369163 4-chloro-N-[4-(3-methyl-1H-pyrazolo[3,4- d]pyrimidin-4- yl)phenyl]benzenesulfonamide::US10227357, Compound P-0445 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369163 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369163&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114559 402365959 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729392 Cc1n[nH]c2ncnc(-c3ccc(NS(=O)(=O)c4ccc(C)cc4)cc3)c12 InChI=1S/C19H17N5O2S/c1-12-3-9-16(10-4-12)27(25,26)24-15-7-5-14(6-8-15)18-17-13(2)22-23-19(17)21-11-20-18/h3-11,24H,1-2H3,(H,20,21,22,23) QXKRFXFBIUHXGO-UHFFFAOYSA-N 369164 4-methyl-N-[4-(3-methyl-1H- pyrazolo[3,4-d]pyrimidin-4- yl)phenyl]benzenesulfonamide::US10227357, Compound P-0447 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369164 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369164&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114337 402365960 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729393 Cc1n[nH]c2ncnc(-c3ccc(NS(=O)(=O)c4ccc(C)cc4)cc3)c12 InChI=1S/C19H17N5O2S/c1-12-3-9-16(10-4-12)27(25,26)24-15-7-5-14(6-8-15)18-17-13(2)22-23-19(17)21-11-20-18/h3-11,24H,1-2H3,(H,20,21,22,23) QXKRFXFBIUHXGO-UHFFFAOYSA-N 369164 4-methyl-N-[4-(3-methyl-1H- pyrazolo[3,4-d]pyrimidin-4- yl)phenyl]benzenesulfonamide::US10227357, Compound P-0447 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369164 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369164&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114337 402365960 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729394 Cc1c[nH]c2ncnc(-c3ccc(NS(=O)(=O)c4ccc(C)cc4)cc3)c12 InChI=1S/C20H18N4O2S/c1-13-3-9-17(10-4-13)27(25,26)24-16-7-5-15(6-8-16)19-18-14(2)11-21-20(18)23-12-22-19/h3-12,24H,1-2H3,(H,21,22,23) AZGYEGKAMUPHHW-UHFFFAOYSA-N 369165 4-methyl-N-[4-(5-methyl-7H-pyrrolo[2,3- d]pyrimidin-4- yl)phenyl]benzenesulfonamide::US10227357, Compound P-0448 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369165 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369165&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114965 402365961 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729395 Cc1c[nH]c2ncnc(-c3ccc(NS(=O)(=O)c4ccc(C)cc4)cc3)c12 InChI=1S/C20H18N4O2S/c1-13-3-9-17(10-4-13)27(25,26)24-16-7-5-15(6-8-16)19-18-14(2)11-21-20(18)23-12-22-19/h3-12,24H,1-2H3,(H,21,22,23) AZGYEGKAMUPHHW-UHFFFAOYSA-N 369165 4-methyl-N-[4-(5-methyl-7H-pyrrolo[2,3- d]pyrimidin-4- yl)phenyl]benzenesulfonamide::US10227357, Compound P-0448 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369165 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369165&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114965 402365961 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729396 Cc1[nH]c2ncnc(-c3ccc(NS(=O)(=O)c4ccc(C)cc4)cc3)c2c1C InChI=1S/C21H20N4O2S/c1-13-4-10-18(11-5-13)28(26,27)25-17-8-6-16(7-9-17)20-19-14(2)15(3)24-21(19)23-12-22-20/h4-12,25H,1-3H3,(H,22,23,24) GBPYVAYVDQLDNQ-UHFFFAOYSA-N 369166 N-[4-(5,6-dimethyl-7H-pyrrolo[2,3- d]pyrimidin-4-yl)phenyl]-4-methyl- benzenesulfonamide::US10227357, Compound P-0449 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369166 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369166&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114476 402365962 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729397 Cc1[nH]c2ncnc(-c3ccc(NS(=O)(=O)c4ccc(C)cc4)cc3)c2c1C InChI=1S/C21H20N4O2S/c1-13-4-10-18(11-5-13)28(26,27)25-17-8-6-16(7-9-17)20-19-14(2)15(3)24-21(19)23-12-22-20/h4-12,25H,1-3H3,(H,22,23,24) GBPYVAYVDQLDNQ-UHFFFAOYSA-N 369166 N-[4-(5,6-dimethyl-7H-pyrrolo[2,3- d]pyrimidin-4-yl)phenyl]-4-methyl- benzenesulfonamide::US10227357, Compound P-0449 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369166 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369166&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114476 402365962 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729398 Cc1nc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2ccc(C)cc2)cc1 InChI=1S/C19H17N5O2S/c1-12-3-9-16(10-4-12)27(25,26)24-15-7-5-14(6-8-15)17-18-19(21-11-20-17)23-13(2)22-18/h3-11,24H,1-2H3,(H,20,21,22,23) BNCINZJILOJIMH-UHFFFAOYSA-N 369167 4-methyl-N-[4-(8-methyl-9H-purin-6- yl)phenyl]benzenesulfonamide::US10227357, Compound P-0450 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369167 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369167&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114969 402365963 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729399 Cc1nc2c(ncnc2[nH]1)-c1ccc(NS(=O)(=O)c2ccc(C)cc2)cc1 InChI=1S/C19H17N5O2S/c1-12-3-9-16(10-4-12)27(25,26)24-15-7-5-14(6-8-15)17-18-19(21-11-20-17)23-13(2)22-18/h3-11,24H,1-2H3,(H,20,21,22,23) BNCINZJILOJIMH-UHFFFAOYSA-N 369167 4-methyl-N-[4-(8-methyl-9H-purin-6- yl)phenyl]benzenesulfonamide::US10227357, Compound P-0450 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369167 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369167&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114969 402365963 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729400 Cc1ccc(cc1)S(=O)(=O)NC1CCN(CC1)c1ncnc2[nH]c(cc12)-c1cnn(C)c1 InChI=1S/C22H25N7O2S/c1-15-3-5-18(6-4-15)32(30,31)27-17-7-9-29(10-8-17)22-19-11-20(16-12-25-28(2)13-16)26-21(19)23-14-24-22/h3-6,11-14,17,27H,7-10H2,1-2H3,(H,23,24,26) MYUGAKPPYLKRQH-UHFFFAOYSA-N 369168 4-methyl-N-[1-[6-(1-methylpyrazol-4- yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-4- piperidyl]benzenesulfonamide::US10227357, Compound P-0451 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369168 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369168&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115080 402365964 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729401 Cc1ccc(cc1)S(=O)(=O)NC1CCN(CC1)c1ncnc2[nH]c(cc12)-c1cnn(C)c1 InChI=1S/C22H25N7O2S/c1-15-3-5-18(6-4-15)32(30,31)27-17-7-9-29(10-8-17)22-19-11-20(16-12-25-28(2)13-16)26-21(19)23-14-24-22/h3-6,11-14,17,27H,7-10H2,1-2H3,(H,23,24,26) MYUGAKPPYLKRQH-UHFFFAOYSA-N 369168 4-methyl-N-[1-[6-(1-methylpyrazol-4- yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-4- piperidyl]benzenesulfonamide::US10227357, Compound P-0451 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369168 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369168&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115080 402365964 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729402 Cn1cc(cn1)-c1cc2c(ncnc2[nH]1)N1CCC(CC1)NS(=O)(=O)c1ccc2CCCc2c1 InChI=1S/C24H27N7O2S/c1-30-14-18(13-27-30)22-12-21-23(28-22)25-15-26-24(21)31-9-7-19(8-10-31)29-34(32,33)20-6-5-16-3-2-4-17(16)11-20/h5-6,11-15,19,29H,2-4,7-10H2,1H3,(H,25,26,28) HTEZAOGPPDSGDI-UHFFFAOYSA-N 369169 N-[1-[6-(1-methylpyrazol-4-yl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]-4- piperidyl]indane-5-sulfonamide::US10227357, Compound P-0452 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369169 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369169&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114855 402365965 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729403 Cn1cc(cn1)-c1cc2c(ncnc2[nH]1)N1CCC(CC1)NS(=O)(=O)c1ccc2CCCc2c1 InChI=1S/C24H27N7O2S/c1-30-14-18(13-27-30)22-12-21-23(28-22)25-15-26-24(21)31-9-7-19(8-10-31)29-34(32,33)20-6-5-16-3-2-4-17(16)11-20/h5-6,11-15,19,29H,2-4,7-10H2,1H3,(H,25,26,28) HTEZAOGPPDSGDI-UHFFFAOYSA-N 369169 N-[1-[6-(1-methylpyrazol-4-yl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]-4- piperidyl]indane-5-sulfonamide::US10227357, Compound P-0452 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369169 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369169&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114855 402365965 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729404 Cc1csc(c1)S(=O)(=O)NC1CCN(CC1)c1ncnc2[nH]c(cc12)-c1cnn(C)c1 InChI=1S/C20H23N7O2S2/c1-13-7-18(30-11-13)31(28,29)25-15-3-5-27(6-4-15)20-16-8-17(14-9-23-26(2)10-14)24-19(16)21-12-22-20/h7-12,15,25H,3-6H2,1-2H3,(H,21,22,24) ZTSSOEOMBPLIRF-UHFFFAOYSA-N 369170 4-methyl-N-[1-[6-(1-methylpyrazol-4- yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-4- piperidyl]thiophene-2-sulfonamide::US10227357, Compound P-0453 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369170 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369170&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114445 402365966 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729405 Cc1ccc(s1)S(=O)(=O)NC1CCN(CC1)c1ncnc2[nH]c(cc12)-c1cnn(C)c1 InChI=1S/C20H23N7O2S2/c1-13-3-4-18(30-13)31(28,29)25-15-5-7-27(8-6-15)20-16-9-17(14-10-23-26(2)11-14)24-19(16)21-12-22-20/h3-4,9-12,15,25H,5-8H2,1-2H3,(H,21,22,24) CSAWOBYLQMZYDW-UHFFFAOYSA-N 369171 5-methyl-N-[1-[6-(1-methylpyrazol-4- yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-4- piperidyl]thiophene-2-sulfonamide::US10227357, Compound P-0454 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369171 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369171&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114314 402365967 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729406 Cc1ccc(s1)S(=O)(=O)NC1CCN(CC1)c1ncnc2[nH]c(cc12)-c1cnn(C)c1 InChI=1S/C20H23N7O2S2/c1-13-3-4-18(30-13)31(28,29)25-15-5-7-27(8-6-15)20-16-9-17(14-10-23-26(2)11-14)24-19(16)21-12-22-20/h3-4,9-12,15,25H,5-8H2,1-2H3,(H,21,22,24) CSAWOBYLQMZYDW-UHFFFAOYSA-N 369171 5-methyl-N-[1-[6-(1-methylpyrazol-4- yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-4- piperidyl]thiophene-2-sulfonamide::US10227357, Compound P-0454 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369171 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369171&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114314 402365967 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729407 Cc1ccc2sc(cc2c1)S(=O)(=O)NC1CCN(CC1)c1ncnc2[nH]c(cc12)-c1cnn(C)c1 InChI=1S/C24H25N7O2S2/c1-15-3-4-21-16(9-15)10-22(34-21)35(32,33)29-18-5-7-31(8-6-18)24-19-11-20(17-12-27-30(2)13-17)28-23(19)25-14-26-24/h3-4,9-14,18,29H,5-8H2,1-2H3,(H,25,26,28) UVIRMPHCJJRHET-UHFFFAOYSA-N 369172 5-methyl-N-[1-[6-(1-methylpyrazol-4- yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-4- piperidyl]benzothiophene-2- sulfonamide::US10227357, Compound P-0455 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369172 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369172&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114190 402365968 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729408 Cc1ccc2sc(cc2c1)S(=O)(=O)NC1CCN(CC1)c1ncnc2[nH]c(cc12)-c1cnn(C)c1 InChI=1S/C24H25N7O2S2/c1-15-3-4-21-16(9-15)10-22(34-21)35(32,33)29-18-5-7-31(8-6-18)24-19-11-20(17-12-27-30(2)13-17)28-23(19)25-14-26-24/h3-4,9-14,18,29H,5-8H2,1-2H3,(H,25,26,28) UVIRMPHCJJRHET-UHFFFAOYSA-N 369172 5-methyl-N-[1-[6-(1-methylpyrazol-4- yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-4- piperidyl]benzothiophene-2- sulfonamide::US10227357, Compound P-0455 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369172 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369172&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114190 402365968 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729409 Cn1cc(cn1)-c1cc2c(ncnc2[nH]1)N1CCC(CC1)NS(=O)(=O)c1ccc2OCOc2c1 InChI=1S/C22H23N7O4S/c1-28-11-14(10-25-28)18-9-17-21(26-18)23-12-24-22(17)29-6-4-15(5-7-29)27-34(30,31)16-2-3-19-20(8-16)33-13-32-19/h2-3,8-12,15,27H,4-7,13H2,1H3,(H,23,24,26) RSYJGWSPTGGGSS-UHFFFAOYSA-N 369173 N-[1-[6-(1-methylpyrazol-4-yl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]-4- piperidyl]-1,3-benzodioxole-5- sulfonamide::US10227357, Compound P-0456 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369173 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369173&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114373 402365969 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729410 Cn1cc(cn1)-c1cc2c(ncnc2[nH]1)N1CCC(CC1)NS(=O)(=O)c1ccc2OCCc2c1 InChI=1S/C23H25N7O3S/c1-29-13-16(12-26-29)20-11-19-22(27-20)24-14-25-23(19)30-7-4-17(5-8-30)28-34(31,32)18-2-3-21-15(10-18)6-9-33-21/h2-3,10-14,17,28H,4-9H2,1H3,(H,24,25,27) QVQZZJDVMRESDQ-UHFFFAOYSA-N 369174 N-[1-[6-(1-methylpyrazol-4-yl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]-4- piperidyl]-2,3-dihydrobenzofuran-5- sulfonamide::US10227357, Compound P-0457 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369174 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369174&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115102 402365970 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729411 Cn1cc(cn1)-c1cc2c(ncnc2[nH]1)N1CCC(CC1)NS(=O)(=O)c1ccc2OCCc2c1 InChI=1S/C23H25N7O3S/c1-29-13-16(12-26-29)20-11-19-22(27-20)24-14-25-23(19)30-7-4-17(5-8-30)28-34(31,32)18-2-3-21-15(10-18)6-9-33-21/h2-3,10-14,17,28H,4-9H2,1H3,(H,24,25,27) QVQZZJDVMRESDQ-UHFFFAOYSA-N 369174 N-[1-[6-(1-methylpyrazol-4-yl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]-4- piperidyl]-2,3-dihydrobenzofuran-5- sulfonamide::US10227357, Compound P-0457 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369174 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369174&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115102 402365970 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729412 Cn1cc(cn1)-c1cc2c(ncnc2[nH]1)N1CCC(CC1)NS(=O)(=O)c1ccc(Cl)s1 InChI=1S/C19H20ClN7O2S2/c1-26-10-12(9-23-26)15-8-14-18(24-15)21-11-22-19(14)27-6-4-13(5-7-27)25-31(28,29)17-3-2-16(20)30-17/h2-3,8-11,13,25H,4-7H2,1H3,(H,21,22,24) SDDRDSKQYOEATQ-UHFFFAOYSA-N 369175 5-chloro-N-[1-[6-(1-methylpyrazol-4- yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-4- piperidyl]thiophene-2-sulfonamide::US10227357, Compound P-0458 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369175 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369175&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115066 402365971 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729413 Cn1cc(cn1)-c1cc2c(ncnc2[nH]1)N1CCC(CC1)NS(=O)(=O)c1ccc(Cl)s1 InChI=1S/C19H20ClN7O2S2/c1-26-10-12(9-23-26)15-8-14-18(24-15)21-11-22-19(14)27-6-4-13(5-7-27)25-31(28,29)17-3-2-16(20)30-17/h2-3,8-11,13,25H,4-7H2,1H3,(H,21,22,24) SDDRDSKQYOEATQ-UHFFFAOYSA-N 369175 5-chloro-N-[1-[6-(1-methylpyrazol-4- yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-4- piperidyl]thiophene-2-sulfonamide::US10227357, Compound P-0458 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369175 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369175&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115066 402365971 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729414 Cc1ccc(cn1)-c1cc2c(ncnc2[nH]1)N1CCC(CC1)NS(=O)(=O)c1ccc(OC(F)(F)F)cc1 InChI=1S/C24H23F3N6O3S/c1-15-2-3-16(13-28-15)21-12-20-22(31-21)29-14-30-23(20)33-10-8-17(9-11-33)32-37(34,35)19-6-4-18(5-7-19)36-24(25,26)27/h2-7,12-14,17,32H,8-11H2,1H3,(H,29,30,31) WZJXBHDACCMKMG-UHFFFAOYSA-N 369176 N-[1-[6-(6-methyl-3-pyridyl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]-4- piperidyl]-4- (trifluoromethoxy)benzenesulfonamide::US10227357, Compound P-0459 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369176 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369176&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114368 402365972 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729415 COc1cc(ccn1)-c1cc2c(ncnc2[nH]1)N1CCC(CC1)NS(=O)(=O)c1ccc(OC(F)(F)F)cc1 InChI=1S/C24H23F3N6O4S/c1-36-21-12-15(6-9-28-21)20-13-19-22(31-20)29-14-30-23(19)33-10-7-16(8-11-33)32-38(34,35)18-4-2-17(3-5-18)37-24(25,26)27/h2-6,9,12-14,16,32H,7-8,10-11H2,1H3,(H,29,30,31) QMCAKHZCYZVSRK-UHFFFAOYSA-N 369177 N-[1-[6-(2-methoxy-4-pyridyl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]-4- piperidyl]-4- (trifluoromethoxy)benzenesulfonamide::US10227357, Compound P-0460 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369177 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369177&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114463 402365973 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729416 COc1cc(ccn1)-c1cc2c(ncnc2[nH]1)N1CCC(CC1)NS(=O)(=O)c1ccc(OC(F)(F)F)cc1 InChI=1S/C24H23F3N6O4S/c1-36-21-12-15(6-9-28-21)20-13-19-22(31-20)29-14-30-23(19)33-10-7-16(8-11-33)32-38(34,35)18-4-2-17(3-5-18)37-24(25,26)27/h2-6,9,12-14,16,32H,7-8,10-11H2,1H3,(H,29,30,31) QMCAKHZCYZVSRK-UHFFFAOYSA-N 369177 N-[1-[6-(2-methoxy-4-pyridyl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]-4- piperidyl]-4- (trifluoromethoxy)benzenesulfonamide::US10227357, Compound P-0460 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369177 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369177&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114463 402365973 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729417 Cn1cc(cn1)-c1cc2c(ncnc2[nH]1)N1CCC(CC1)NS(=O)(=O)c1cc(Cl)c(Cl)s1 InChI=1S/C19H19Cl2N7O2S2/c1-27-9-11(8-24-27)15-6-13-18(25-15)22-10-23-19(13)28-4-2-12(3-5-28)26-32(29,30)16-7-14(20)17(21)31-16/h6-10,12,26H,2-5H2,1H3,(H,22,23,25) JGKRYIMOOKSSPU-UHFFFAOYSA-N 369178 4,5-dichloro-N-[1-[6-(1-methylpyrazol- 4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]- 4-piperidyl]thiophene-2-sulfonamide::US10227357, Compound P-0461 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369178 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369178&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115364 402365974 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729418 Cn1cc(cn1)-c1cc2c(ncnc2[nH]1)N1CCC(CC1)NS(=O)(=O)c1cc(Cl)c(Cl)s1 InChI=1S/C19H19Cl2N7O2S2/c1-27-9-11(8-24-27)15-6-13-18(25-15)22-10-23-19(13)28-4-2-12(3-5-28)26-32(29,30)16-7-14(20)17(21)31-16/h6-10,12,26H,2-5H2,1H3,(H,22,23,25) JGKRYIMOOKSSPU-UHFFFAOYSA-N 369178 4,5-dichloro-N-[1-[6-(1-methylpyrazol- 4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]- 4-piperidyl]thiophene-2-sulfonamide::US10227357, Compound P-0461 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369178 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369178&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115364 402365974 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729419 Cn1cc(cn1)-c1cc2c(ncnc2[nH]1)N1CCC(CC1)NS(=O)(=O)c1cc(Cl)cs1 InChI=1S/C19H20ClN7O2S2/c1-26-9-12(8-23-26)16-7-15-18(24-16)21-11-22-19(15)27-4-2-14(3-5-27)25-31(28,29)17-6-13(20)10-30-17/h6-11,14,25H,2-5H2,1H3,(H,21,22,24) CBCMZIHECPMJII-UHFFFAOYSA-N 369179 4-chloro-N-[1-[6-(1-methylpyrazol-4- yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-4- piperidyl]thiophene-2-sulfonamide::US10227357, Compound P-0462 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369179 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369179&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114391 402365975 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729420 Cn1cc(cn1)-c1cc2c(ncnc2[nH]1)N1CCC(CC1)NS(=O)(=O)c1cc(Cl)cs1 InChI=1S/C19H20ClN7O2S2/c1-26-9-12(8-23-26)16-7-15-18(24-16)21-11-22-19(15)27-4-2-14(3-5-27)25-31(28,29)17-6-13(20)10-30-17/h6-11,14,25H,2-5H2,1H3,(H,21,22,24) CBCMZIHECPMJII-UHFFFAOYSA-N 369179 4-chloro-N-[1-[6-(1-methylpyrazol-4- yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-4- piperidyl]thiophene-2-sulfonamide::US10227357, Compound P-0462 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369179 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369179&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114391 402365975 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729421 Cc1ncc(s1)-c1cc2c(ncnc2[nH]1)N1CCC(CC1)NS(=O)(=O)c1ccc(OC(F)(F)F)cc1 InChI=1S/C22H21F3N6O3S2/c1-13-26-11-19(35-13)18-10-17-20(29-18)27-12-28-21(17)31-8-6-14(7-9-31)30-36(32,33)16-4-2-15(3-5-16)34-22(23,24)25/h2-5,10-12,14,30H,6-9H2,1H3,(H,27,28,29) BNMOLRALQJSWKL-UHFFFAOYSA-N 369180 N-[1-[6-(2-methylthiazol-5-yl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]-4- piperidyl]-4- (trifluoromethoxy)benzenesulfonamide::US10227357, Compound P-0463 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369180 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369180&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115333 402365976 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729422 FC(F)(F)Oc1ccc(cc1)S(=O)(=O)NC1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(cc1)C#N InChI=1S/C25H21F3N6O3S/c26-25(27,28)37-19-5-7-20(8-6-19)38(35,36)33-18-9-11-34(12-10-18)24-21-13-22(32-23(21)30-15-31-24)17-3-1-16(14-29)2-4-17/h1-8,13,15,18,33H,9-12H2,(H,30,31,32) GIQSGYQIOBTICH-UHFFFAOYSA-N 369181 N-[1-[6-(4-cyanophenyl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]-4- piperidyl]-4- (trifluoromethoxy)benzenesulfonamide::US10227357, Compound P-0464 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369181 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369181&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114351 402365977 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729423 COc1ncc(cn1)-c1cc2c(ncnc2[nH]1)N1CCC(CC1)NS(=O)(=O)c1ccc(OC(F)(F)F)cc1 InChI=1S/C23H22F3N7O4S/c1-36-22-27-11-14(12-28-22)19-10-18-20(31-19)29-13-30-21(18)33-8-6-15(7-9-33)32-38(34,35)17-4-2-16(3-5-17)37-23(24,25)26/h2-5,10-13,15,32H,6-9H2,1H3,(H,29,30,31) GJWSLNGNKQPYRD-UHFFFAOYSA-N 369182 N-[1-[6-(2-methoxypyrimidin-5-yl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]-4- piperidyl]-4- (trifluoromethoxy)benzenesulfonamide::US10227357, Compound P-0465 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369182 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369182&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115157 402365978 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729424 COc1ncc(cn1)-c1cc2c(ncnc2[nH]1)N1CCC(CC1)NS(=O)(=O)c1ccc(OC(F)(F)F)cc1 InChI=1S/C23H22F3N7O4S/c1-36-22-27-11-14(12-28-22)19-10-18-20(31-19)29-13-30-21(18)33-8-6-15(7-9-33)32-38(34,35)17-4-2-16(3-5-17)37-23(24,25)26/h2-5,10-13,15,32H,6-9H2,1H3,(H,29,30,31) GJWSLNGNKQPYRD-UHFFFAOYSA-N 369182 N-[1-[6-(2-methoxypyrimidin-5-yl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]-4- piperidyl]-4- (trifluoromethoxy)benzenesulfonamide::US10227357, Compound P-0465 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369182 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369182&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115157 402365978 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729425 Clc1ccc(cc1)-c1cc2c(ncnc2[nH]1)N1CCC(CC1)NS(=O)(=O)c1cc2ccccc2s1 InChI=1S/C25H22ClN5O2S2/c26-18-7-5-16(6-8-18)21-14-20-24(29-21)27-15-28-25(20)31-11-9-19(10-12-31)30-35(32,33)23-13-17-3-1-2-4-22(17)34-23/h1-8,13-15,19,30H,9-12H2,(H,27,28,29) BRRKSBXYKNUDDA-UHFFFAOYSA-N 369183 N-[1-[6-(4-chlorophenyl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]-4- piperidyl]benzothiophene-2- sulfonamide::US10227357, Compound P-0467 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369183 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369183&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114278 402365979 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729426 CC(C)Oc1ccc(cc1)S(=O)(=O)NC1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(Cl)cc1 InChI=1S/C26H28ClN5O3S/c1-17(2)35-21-7-9-22(10-8-21)36(33,34)31-20-11-13-32(14-12-20)26-23-15-24(30-25(23)28-16-29-26)18-3-5-19(27)6-4-18/h3-10,15-17,20,31H,11-14H2,1-2H3,(H,28,29,30) MGLJAIHQTRECIP-UHFFFAOYSA-N 369184 N-[1-[6-(4-chlorophenyl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]-4- piperidyl]-4-isopropoxy- benzenesulfonamide::US10227357, Compound P-0468 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369184 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369184&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114339 402365980 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729427 CN(C)S(=O)(=O)NC1CCN(CC1)c1ncnc2[nH]c(cc12)-c1cnn(C)c1 InChI=1S/C17H24N8O2S/c1-23(2)28(26,27)22-13-4-6-25(7-5-13)17-14-8-15(12-9-20-24(3)10-12)21-16(14)18-11-19-17/h8-11,13,22H,4-7H2,1-3H3,(H,18,19,21) LORDHCKHZIYLEZ-UHFFFAOYSA-N 369185 4-[4-(dimethylsulfamoylamino)-1- piperidyl]-6-(1-methylpyrazol-4-yl)-7H- pyrrolo[2,3-d]pyrimidine::US10227357, Compound P-0469 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369185 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369185&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114945 402365981 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729428 Cn1cc(cn1)-c1cc2c(ncnc2[nH]1)N1CCC(CC1)NS(=O)(=O)c1cc2ccccc2s1 InChI=1S/C23H23N7O2S2/c1-29-13-16(12-26-29)19-11-18-22(27-19)24-14-25-23(18)30-8-6-17(7-9-30)28-34(31,32)21-10-15-4-2-3-5-20(15)33-21/h2-5,10-14,17,28H,6-9H2,1H3,(H,24,25,27) UMEUUFQGIQECRI-UHFFFAOYSA-N 369186 N-[1-[6-(1-methylpyrazol-4-yl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]-4- piperidyl]benzothiophene-2- sulfonamide::US10227357, Compound P-0470 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369186 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369186&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115057 402365982 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729429 Cn1cc(cn1)-c1cc2c(ncnc2[nH]1)N1CCC(CC1)NS(=O)(=O)c1cc2ccccc2s1 InChI=1S/C23H23N7O2S2/c1-29-13-16(12-26-29)19-11-18-22(27-19)24-14-25-23(18)30-8-6-17(7-9-30)28-34(31,32)21-10-15-4-2-3-5-20(15)33-21/h2-5,10-14,17,28H,6-9H2,1H3,(H,24,25,27) UMEUUFQGIQECRI-UHFFFAOYSA-N 369186 N-[1-[6-(1-methylpyrazol-4-yl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]-4- piperidyl]benzothiophene-2- sulfonamide::US10227357, Compound P-0470 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369186 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369186&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115057 402365982 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729430 Clc1ccc(cc1)S(=O)(=O)NC1CCN(CC1)c1ncnc2[nH]c(cc12)C#CC1CC1 InChI=1S/C22H22ClN5O2S/c23-16-4-7-19(8-5-16)31(29,30)27-17-9-11-28(12-10-17)22-20-13-18(6-3-15-1-2-15)26-21(20)24-14-25-22/h4-5,7-8,13-15,17,27H,1-2,9-12H2,(H,24,25,26) ZGRONAPUUHIOSL-UHFFFAOYSA-N 369187 4-chloro-N-[1-[6-(2- cyclopropylethynyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-4- piperidyl]benzenesulfonamide::US10227357, Compound P-0471 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369187 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369187&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114798 402365983 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729431 CS(=O)(=O)NC1CCN(CC1)c1ncnc2[nH]c(cc12)C#CC1CC1 InChI=1S/C17H21N5O2S/c1-25(23,24)21-13-6-8-22(9-7-13)17-15-10-14(5-4-12-2-3-12)20-16(15)18-11-19-17/h10-13,21H,2-3,6-9H2,1H3,(H,18,19,20) RDAOIJCNNDKVRE-UHFFFAOYSA-N 369188 N-[1-[6-(2-cyclopropylethynyl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]-4- piperidyl]methanesulfonamide::US10227357, Compound P-0472 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369188 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369188&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114726 402365984 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729432 Clc1ccc(cc1)-c1cc2c(ncnc2[nH]1)N1CCC(CC1)NS(=O)(=O)c1ccc(cc1)N1CCCC1=O InChI=1S/C27H27ClN6O3S/c28-19-5-3-18(4-6-19)24-16-23-26(31-24)29-17-30-27(23)33-14-11-20(12-15-33)32-38(36,37)22-9-7-21(8-10-22)34-13-1-2-25(34)35/h3-10,16-17,20,32H,1-2,11-15H2,(H,29,30,31) XLXPIGKOJOVZMM-UHFFFAOYSA-N 369189 N-[1-[6-(4-chlorophenyl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]-4- piperidyl]-4-(2-oxopyrrolidin-1- yl)benzenesulfonamide::US10227357, Compound P-0473 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369189 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369189&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115040 402365985 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729433 Clc1ccc(cc1)-c1cc2c(ncnc2[nH]1)N1CCC(CC1)NS(=O)(=O)c1cccc(Cl)c1 InChI=1S/C23H21Cl2N5O2S/c24-16-6-4-15(5-7-16)21-13-20-22(28-21)26-14-27-23(20)30-10-8-18(9-11-30)29-33(31,32)19-3-1-2-17(25)12-19/h1-7,12-14,18,29H,8-11H2,(H,26,27,28) DSNINMJEUJNDDT-UHFFFAOYSA-N 369190 3-chloro-N-[1-[6-(4-chlorophenyl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]-4- piperidyl]benzenesulfonamide::US10227357, Compound P-0480 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369190 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369190&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114488 402365986 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729434 Fc1ccc(cc1)S(=O)(=O)NC1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(Cl)cc1 InChI=1S/C23H21ClFN5O2S/c24-16-3-1-15(2-4-16)21-13-20-22(28-21)26-14-27-23(20)30-11-9-18(10-12-30)29-33(31,32)19-7-5-17(25)6-8-19/h1-8,13-14,18,29H,9-12H2,(H,26,27,28) YUPMCIYAMXMIPD-UHFFFAOYSA-N 369191 N-[1-[6-(4-chlorophenyl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]-4- piperidyl]-4-fluoro- benzenesulfonamide::US10227357, Compound P-0481 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369191 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369191&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114459 402365987 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729435 Cn1cc(cn1)-c1cc2c(ncnc2[nH]1)N1CCC(CC1)NS(=O)(=O)c1ccc(cc1)N1CCCC1=O InChI=1S/C25H28N8O3S/c1-31-15-17(14-28-31)22-13-21-24(29-22)26-16-27-25(21)32-11-8-18(9-12-32)30-37(35,36)20-6-4-19(5-7-20)33-10-2-3-23(33)34/h4-7,13-16,18,30H,2-3,8-12H2,1H3,(H,26,27,29) JXWAGMKGNBOCBK-UHFFFAOYSA-N 369192 N-[1-[6-(1-methylpyrazol-4-yl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]-4- piperidyl]-4-(2-oxopyrrolidin-1- yl)benzenesulfonamide::US10227357, Compound P-0483 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369192 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369192&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114904 402365988 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729436 CCCn1cc(cn1)S(=O)(=O)NC1CCN(CC1)c1ncnc2[nH]c(cc12)-c1cnn(C)c1 InChI=1S/C21H27N9O2S/c1-3-6-30-13-17(11-25-30)33(31,32)27-16-4-7-29(8-5-16)21-18-9-19(15-10-24-28(2)12-15)26-20(18)22-14-23-21/h9-14,16,27H,3-8H2,1-2H3,(H,22,23,26) PHCXPHOOYAJHJD-UHFFFAOYSA-N 369193 N-[1-[6-(1-methylpyrazol-4-yl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]-4- piperidyl]-1-propyl-pyrazole-4- sulfonamide::US10227357, Compound P-0484 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369193 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369193&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114404 402365989 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729437 Cn1cc(cn1)-c1cc2c(ncnc2[nH]1)N1CCC(CC1)NS(=O)(=O)c1ccc(cc1)C1(CC1)C#N InChI=1S/C25H26N8O2S/c1-32-14-17(13-29-32)22-12-21-23(30-22)27-16-28-24(21)33-10-6-19(7-11-33)31-36(34,35)20-4-2-18(3-5-20)25(15-26)8-9-25/h2-5,12-14,16,19,31H,6-11H2,1H3,(H,27,28,30) URDJAURTHAKVEQ-UHFFFAOYSA-N 369194 4-(1-cyanocyclopropyl)-N-[1-[6-(1- methylpyrazol-4-yl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-4- piperidyl]benzenesulfonamide::US10227357, Compound P-0486 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369194 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369194&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114324 402365990 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729438 Cn1cc(cn1)-c1cc2c(ncnc2[nH]1)N1CCC(CC1)NS(=O)(=O)c1ccc(cc1)C1(CC1)C#N InChI=1S/C25H26N8O2S/c1-32-14-17(13-29-32)22-12-21-23(30-22)27-16-28-24(21)33-10-6-19(7-11-33)31-36(34,35)20-4-2-18(3-5-20)25(15-26)8-9-25/h2-5,12-14,16,19,31H,6-11H2,1H3,(H,27,28,30) URDJAURTHAKVEQ-UHFFFAOYSA-N 369194 4-(1-cyanocyclopropyl)-N-[1-[6-(1- methylpyrazol-4-yl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-4- piperidyl]benzenesulfonamide::US10227357, Compound P-0486 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369194 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369194&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114324 402365990 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729439 CC(C)Oc1ccc(cc1)S(=O)(=O)NC1CCN(CC1)c1ncnc2[nH]c(cc12)-c1cnn(C)c1 InChI=1S/C24H29N7O3S/c1-16(2)34-19-4-6-20(7-5-19)35(32,33)29-18-8-10-31(11-9-18)24-21-12-22(17-13-27-30(3)14-17)28-23(21)25-15-26-24/h4-7,12-16,18,29H,8-11H2,1-3H3,(H,25,26,28) MVEOBVQNJBKZQT-UHFFFAOYSA-N 369195 4-isopropoxy-N-[1-[6-(1-methylpyrazol- 4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]- 4-piperidyl]benzenesulfonamide::US10227357, Compound P-0488 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369195 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369195&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114776 402365991 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729440 CC(C)Oc1ccc(cc1)S(=O)(=O)NC1CCN(CC1)c1ncnc2[nH]c(cc12)-c1cnn(C)c1 InChI=1S/C24H29N7O3S/c1-16(2)34-19-4-6-20(7-5-19)35(32,33)29-18-8-10-31(11-9-18)24-21-12-22(17-13-27-30(3)14-17)28-23(21)25-15-26-24/h4-7,12-16,18,29H,8-11H2,1-3H3,(H,25,26,28) MVEOBVQNJBKZQT-UHFFFAOYSA-N 369195 4-isopropoxy-N-[1-[6-(1-methylpyrazol- 4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]- 4-piperidyl]benzenesulfonamide::US10227357, Compound P-0488 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369195 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369195&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114776 402365991 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729441 Cn1cc(cn1)-c1cc2c(ncnc2[nH]1)N1CCC(CC1)NS(=O)(=O)c1ccc(F)cc1 InChI=1S/C21H22FN7O2S/c1-28-12-14(11-25-28)19-10-18-20(26-19)23-13-24-21(18)29-8-6-16(7-9-29)27-32(30,31)17-4-2-15(22)3-5-17/h2-5,10-13,16,27H,6-9H2,1H3,(H,23,24,26) GRPJHBCXINKHCY-UHFFFAOYSA-N 369196 4-fluoro-N-[1-[6-(1-methylpyrazol-4- yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-4- piperidyl]benzenesulfonamide::US10227357, Compound P-0490 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369196 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369196&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114679 402365992 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729442 Cn1cc(cn1)-c1cc2c(ncnc2[nH]1)N1CCC(CC1)NS(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C21H22ClN7O2S/c1-28-12-14(11-25-28)19-10-18-20(26-19)23-13-24-21(18)29-8-6-16(7-9-29)27-32(30,31)17-4-2-15(22)3-5-17/h2-5,10-13,16,27H,6-9H2,1H3,(H,23,24,26) SWAHJNXSMKYPGK-UHFFFAOYSA-N 369197 4-chloro-N-[1-[6-(1-methylpyrazol-4- yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-4- piperidyl]benzenesulfonamide::US10227357, Compound P-0491 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369197 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369197&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115026 402365993 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729443 Cn1cc(cn1)-c1cc2c(ncnc2[nH]1)N1CCC(CC1)NS(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C21H22ClN7O2S/c1-28-12-14(11-25-28)19-10-18-20(26-19)23-13-24-21(18)29-8-6-16(7-9-29)27-32(30,31)17-4-2-15(22)3-5-17/h2-5,10-13,16,27H,6-9H2,1H3,(H,23,24,26) SWAHJNXSMKYPGK-UHFFFAOYSA-N 369197 4-chloro-N-[1-[6-(1-methylpyrazol-4- yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-4- piperidyl]benzenesulfonamide::US10227357, Compound P-0491 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369197 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369197&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115026 402365993 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729444 Cn1cc(cn1)-c1cc2c(ncnc2[nH]1)N1CCC(CC1)NS(=O)(=O)c1ccccc1OC(F)(F)F InChI=1S/C22H22F3N7O3S/c1-31-12-14(11-28-31)17-10-16-20(29-17)26-13-27-21(16)32-8-6-15(7-9-32)30-36(33,34)19-5-3-2-4-18(19)35-22(23,24)25/h2-5,10-13,15,30H,6-9H2,1H3,(H,26,27,29) HUSFCZOFXIIZSR-UHFFFAOYSA-N 369198 N-[1-[6-(1-methylpyrazol-4-yl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]-4- piperidyl]-2- (trifluoromethoxy)benzenesulfonamide::US10227357, Compound P-0493 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369198 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369198&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114194 402365994 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729445 COc1ccc(cc1)S(=O)(=O)NC1CCN(CC1)c1ncnc2[nH]c(cc12)-c1cnn(C)c1 InChI=1S/C22H25N7O3S/c1-28-13-15(12-25-28)20-11-19-21(26-20)23-14-24-22(19)29-9-7-16(8-10-29)27-33(30,31)18-5-3-17(32-2)4-6-18/h3-6,11-14,16,27H,7-10H2,1-2H3,(H,23,24,26) BKTJFNVDVXGUDQ-UHFFFAOYSA-N 369199 4-methoxy-N-[1-[6-(1-methylpyrazol-4- yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-4- piperidyl]benzenesulfonamide::US10227357, Compound P-0496 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369199 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369199&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114697 402365995 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729446 Cn1cc(cn1)-c1cc2c(ncnc2[nH]1)N1CCC(CC1)NS(=O)(=O)c1ccc(OC(F)(F)F)cc1 InChI=1S/C22H22F3N7O3S/c1-31-12-14(11-28-31)19-10-18-20(29-19)26-13-27-21(18)32-8-6-15(7-9-32)30-36(33,34)17-4-2-16(3-5-17)35-22(23,24)25/h2-5,10-13,15,30H,6-9H2,1H3,(H,26,27,29) TVZUCTLGGVMWEJ-UHFFFAOYSA-N 369200 N-[1-[6-(1-methylpyrazol-4-yl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]-4- piperidyl]-4- (trifluoromethoxy)benzenesulfonamide::US10227357, Compound P-0497 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369200 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369200&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 86718048 402365996 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729447 FC(F)(F)Oc1cccc(c1)S(=O)(=O)NC1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(Cl)cc1 InChI=1S/C24H21ClF3N5O3S/c25-16-6-4-15(5-7-16)21-13-20-22(31-21)29-14-30-23(20)33-10-8-17(9-11-33)32-37(34,35)19-3-1-2-18(12-19)36-24(26,27)28/h1-7,12-14,17,32H,8-11H2,(H,29,30,31) XYWKEDOSVLIQCM-UHFFFAOYSA-N 369201 N-[1-[6-(4-chlorophenyl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]-4- piperidyl]-3- (trifluoromethoxy)benzenesulfonamide::US10227357, Compound P-0499 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369201 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369201&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114601 402365997 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729448 Cn1cc(cn1)-c1cc2c(ncnc2[nH]1)N1CCC(CC1)NS(=O)(=O)c1cccc(OC(F)(F)F)c1 InChI=1S/C22H22F3N7O3S/c1-31-12-14(11-28-31)19-10-18-20(29-19)26-13-27-21(18)32-7-5-15(6-8-32)30-36(33,34)17-4-2-3-16(9-17)35-22(23,24)25/h2-4,9-13,15,30H,5-8H2,1H3,(H,26,27,29) YSEPHBYWAQPKRX-UHFFFAOYSA-N 369202 N-[1-[6-(1-methylpyrazol-4-yl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]-4- piperidyl]-3- (trifluoromethoxy)benzenesulfonamide::US10227357, Compound P-0500 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369202 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369202&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114537 402365998 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729449 CN(C)c1ccc(NC(=O)NC2CCN(CC2)c2ncnc3[nH]ccc23)cc1 InChI=1S/C20H25N7O/c1-26(2)16-5-3-14(4-6-16)24-20(28)25-15-8-11-27(12-9-15)19-17-7-10-21-18(17)22-13-23-19/h3-7,10,13,15H,8-9,11-12H2,1-2H3,(H,21,22,23)(H2,24,25,28) GSGRZGQNYHVVPO-UHFFFAOYSA-N 369203 1-(4-dimethylaminophenyl)-3-[1-(7H- pyrrolo[2,3-d]pyrimidin-4-yl)-4- piperidyl]urea::US10227357, Compound P-0506 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369203 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369203&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115281 402365999 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729450 Cc1nc(no1)-c1cccc(NC(=O)NC2CCN(CC2)c2ncnc3[nH]ccc23)c1 InChI=1S/C21H22N8O2/c1-13-25-18(28-31-13)14-3-2-4-16(11-14)27-21(30)26-15-6-9-29(10-7-15)20-17-5-8-22-19(17)23-12-24-20/h2-5,8,11-12,15H,6-7,9-10H2,1H3,(H,22,23,24)(H2,26,27,30) DBLBTYLZXXCFAM-UHFFFAOYSA-N 369204 1-[3-(5-methyl-1,2,4-oxadiazol-3- yl)phenyl]-3-[1-(7H-pyrrolo[2,3- d]pyrimidin-4-yl)-4-piperidyl]urea::US10227357, Compound P-0507 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369204 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369204&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115440 402366000 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729451 Cc1nc(no1)-c1cccc(NC(=O)NC2CCN(CC2)c2ncnc3[nH]ccc23)c1 InChI=1S/C21H22N8O2/c1-13-25-18(28-31-13)14-3-2-4-16(11-14)27-21(30)26-15-6-9-29(10-7-15)20-17-5-8-22-19(17)23-12-24-20/h2-5,8,11-12,15H,6-7,9-10H2,1H3,(H,22,23,24)(H2,26,27,30) DBLBTYLZXXCFAM-UHFFFAOYSA-N 369204 1-[3-(5-methyl-1,2,4-oxadiazol-3- yl)phenyl]-3-[1-(7H-pyrrolo[2,3- d]pyrimidin-4-yl)-4-piperidyl]urea::US10227357, Compound P-0507 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369204 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369204&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115440 402366000 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729452 O=C(NC1CCN(CC1)c1ncnc2[nH]ccc12)Nc1cccnc1 InChI=1S/C17H19N7O/c25-17(23-13-2-1-6-18-10-13)22-12-4-8-24(9-5-12)16-14-3-7-19-15(14)20-11-21-16/h1-3,6-7,10-12H,4-5,8-9H2,(H,19,20,21)(H2,22,23,25) CEXWJMQAAAKPMH-UHFFFAOYSA-N 369205 1-(3-pyridyl)-3-[1-(7H-pyrrolo[2,3- d]pyrimidin-4-yl)-4-piperidyl]urea::US10227357, Compound P-0508 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369205 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369205&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114758 402366001 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729453 O=C(NC1CCN(CC1)c1ncnc2[nH]ccc12)Nc1cccnc1 InChI=1S/C17H19N7O/c25-17(23-13-2-1-6-18-10-13)22-12-4-8-24(9-5-12)16-14-3-7-19-15(14)20-11-21-16/h1-3,6-7,10-12H,4-5,8-9H2,(H,19,20,21)(H2,22,23,25) CEXWJMQAAAKPMH-UHFFFAOYSA-N 369205 1-(3-pyridyl)-3-[1-(7H-pyrrolo[2,3- d]pyrimidin-4-yl)-4-piperidyl]urea::US10227357, Compound P-0508 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369205 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369205&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114758 402366001 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729454 Fc1ccc(CNC(=O)NC2CCN(CC2)c2ncnc3[nH]ccc23)cc1 InChI=1S/C19H21FN6O/c20-14-3-1-13(2-4-14)11-22-19(27)25-15-6-9-26(10-7-15)18-16-5-8-21-17(16)23-12-24-18/h1-5,8,12,15H,6-7,9-11H2,(H,21,23,24)(H2,22,25,27) BHBJFKLAIVTMAO-UHFFFAOYSA-N 369206 1-[(4-fluorophenyl)methyl]-3-[1-(7H- pyrrolo[2,3-d]pyrimidin-4-yl)-4- piperidyl]urea::US10227357, Compound P-0509 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369206 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369206&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114708 402366002 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729455 Fc1cccc(CNC(=O)NC2CCN(CC2)c2ncnc3[nH]ccc23)c1 InChI=1S/C19H21FN6O/c20-14-3-1-2-13(10-14)11-22-19(27)25-15-5-8-26(9-6-15)18-16-4-7-21-17(16)23-12-24-18/h1-4,7,10,12,15H,5-6,8-9,11H2,(H,21,23,24)(H2,22,25,27) UMHHCEWGIDVIRS-UHFFFAOYSA-N 369207 1-[(3-fluorophenyl)methyl]-3-[1-(7H- pyrrolo[2,3-d]pyrimidin-4-yl)-4- piperidyl]urea::US10227357, Compound P-0510 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369207 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369207&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114983 402366003 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729456 Fc1cccc(CNC(=O)NC2CCN(CC2)c2ncnc3[nH]ccc23)c1 InChI=1S/C19H21FN6O/c20-14-3-1-2-13(10-14)11-22-19(27)25-15-5-8-26(9-6-15)18-16-4-7-21-17(16)23-12-24-18/h1-4,7,10,12,15H,5-6,8-9,11H2,(H,21,23,24)(H2,22,25,27) UMHHCEWGIDVIRS-UHFFFAOYSA-N 369207 1-[(3-fluorophenyl)methyl]-3-[1-(7H- pyrrolo[2,3-d]pyrimidin-4-yl)-4- piperidyl]urea::US10227357, Compound P-0510 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369207 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369207&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114983 402366003 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729457 Fc1ccc(CCNC(=O)NC2CCN(CC2)c2ncnc3[nH]ccc23)cc1 InChI=1S/C20H23FN6O/c21-15-3-1-14(2-4-15)5-9-23-20(28)26-16-7-11-27(12-8-16)19-17-6-10-22-18(17)24-13-25-19/h1-4,6,10,13,16H,5,7-9,11-12H2,(H,22,24,25)(H2,23,26,28) SCFNKUWWVUTAEJ-UHFFFAOYSA-N 369208 1-[2-(4-fluorophenyl)ethyl]-3-[1-(7H- pyrrolo[2,3-d]pyrimidin-4-yl)-4- piperidyl]urea::US10227357, Compound P-0511 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369208 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369208&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114853 402366004 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729458 Fc1ccc(NC(=O)NC2CCN(CC2)c2ncnc3[nH]ccc23)cc1Cl InChI=1S/C18H18ClFN6O/c19-14-9-12(1-2-15(14)20)25-18(27)24-11-4-7-26(8-5-11)17-13-3-6-21-16(13)22-10-23-17/h1-3,6,9-11H,4-5,7-8H2,(H,21,22,23)(H2,24,25,27) PIXHHKXSCPPBKH-UHFFFAOYSA-N 369209 1-(3-chloro-4-fluoro-phenyl)-3-[1-(7H- pyrrolo[2,3-d]pyrimidin-4-yl)-4- piperidyl]urea::US10227357, Compound P-0512 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369209 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369209&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114296 402366005 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729459 FC(F)(F)Oc1ccc(NC(=O)NC2CCN(CC2)c2ncnc3[nH]ccc23)cc1 InChI=1S/C19H19F3N6O2/c20-19(21,22)30-14-3-1-12(2-4-14)26-18(29)27-13-6-9-28(10-7-13)17-15-5-8-23-16(15)24-11-25-17/h1-5,8,11,13H,6-7,9-10H2,(H,23,24,25)(H2,26,27,29) IMZBODRZIQUTLN-UHFFFAOYSA-N 369210 1-[1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)- 4-piperidyl]-3-[4- (trifluoromethoxy)phenyl]urea::US10227357, Compound P-0513 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369210 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369210&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114665 402366006 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729460 FC(F)(F)c1ccc(NC(=O)NC2CCN(CC2)c2ncnc3[nH]ccc23)cc1 InChI=1S/C19H19F3N6O/c20-19(21,22)12-1-3-13(4-2-12)26-18(29)27-14-6-9-28(10-7-14)17-15-5-8-23-16(15)24-11-25-17/h1-5,8,11,14H,6-7,9-10H2,(H,23,24,25)(H2,26,27,29) JBPONLMJEJSYQF-UHFFFAOYSA-N 369211 1-[1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)- 4-piperidyl]-3-[4- (trifluoromethyl)phenyl]urea::US10227357, Compound P-0514 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369211 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369211&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115202 402366007 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729461 FC(F)(F)c1cccc(NC(=O)NC2CCN(CC2)c2ncnc3[nH]ccc23)c1 InChI=1S/C19H19F3N6O/c20-19(21,22)12-2-1-3-14(10-12)27-18(29)26-13-5-8-28(9-6-13)17-15-4-7-23-16(15)24-11-25-17/h1-4,7,10-11,13H,5-6,8-9H2,(H,23,24,25)(H2,26,27,29) DTBFJZGINXULEE-UHFFFAOYSA-N 369212 1-[1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)- 4-piperidyl]-3-[3- (trifluoromethyl)phenyl]urea::US10227357, Compound P-0515 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369212 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369212&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115087 402366008 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729462 FC(F)(F)c1cccc(NC(=O)NC2CCN(CC2)c2ncnc3[nH]ccc23)c1 InChI=1S/C19H19F3N6O/c20-19(21,22)12-2-1-3-14(10-12)27-18(29)26-13-5-8-28(9-6-13)17-15-4-7-23-16(15)24-11-25-17/h1-4,7,10-11,13H,5-6,8-9H2,(H,23,24,25)(H2,26,27,29) DTBFJZGINXULEE-UHFFFAOYSA-N 369212 1-[1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)- 4-piperidyl]-3-[3- (trifluoromethyl)phenyl]urea::US10227357, Compound P-0515 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369212 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369212&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115087 402366008 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729463 Clc1ccc(NC(=O)NC2CCN(CC2)c2ncnc3[nH]ccc23)cc1 InChI=1S/C18H19ClN6O/c19-12-1-3-13(4-2-12)23-18(26)24-14-6-9-25(10-7-14)17-15-5-8-20-16(15)21-11-22-17/h1-5,8,11,14H,6-7,9-10H2,(H,20,21,22)(H2,23,24,26) YLMXVOFNUVBPNW-UHFFFAOYSA-N 369213 1-(4-chlorophenyl)-3-[1-(7H- pyrrolo[2,3-d]pyrimidin-4-yl)-4- piperidyl]urea::US10227357, Compound P-0519 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369213 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369213&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114750 402366009 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729464 O=C(NC1CCN(CC1)c1ncnc2[nH]ccc12)NC(=O)c1ccccc1 InChI=1S/C19H20N6O2/c26-18(13-4-2-1-3-5-13)24-19(27)23-14-7-10-25(11-8-14)17-15-6-9-20-16(15)21-12-22-17/h1-6,9,12,14H,7-8,10-11H2,(H,20,21,22)(H2,23,24,26,27) FRVIMYWHYGHJIF-UHFFFAOYSA-N 369214 N-[[1-(7H-pyrrolo[2,3-d]pyrimidin-4- yl)-4-piperidyl]carbamoyl]benzamide::US10227357, Compound P-0522 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369214 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369214&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114883 402366010 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729465 CCc1ccc(cc1)S(=O)(=O)NC1CCN(CC1)c1ncnc2[nH]ccc12 InChI=1S/C19H23N5O2S/c1-2-14-3-5-16(6-4-14)27(25,26)23-15-8-11-24(12-9-15)19-17-7-10-20-18(17)21-13-22-19/h3-7,10,13,15,23H,2,8-9,11-12H2,1H3,(H,20,21,22) WWYJHURRAOAHHI-UHFFFAOYSA-N 369215 4-ethyl-N-[1-(7H-pyrrolo[2,3- d]pyrimidin-4-yl)-4- piperidyl]benzenesulfonamide::US10227357, Compound P-0525 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369215 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369215&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114520 402366011 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729466 CCc1ccc(cc1)S(=O)(=O)NC1CCN(CC1)c1ncnc2[nH]ccc12 InChI=1S/C19H23N5O2S/c1-2-14-3-5-16(6-4-14)27(25,26)23-15-8-11-24(12-9-15)19-17-7-10-20-18(17)21-13-22-19/h3-7,10,13,15,23H,2,8-9,11-12H2,1H3,(H,20,21,22) WWYJHURRAOAHHI-UHFFFAOYSA-N 369215 4-ethyl-N-[1-(7H-pyrrolo[2,3- d]pyrimidin-4-yl)-4- piperidyl]benzenesulfonamide::US10227357, Compound P-0525 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369215 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369215&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114520 402366011 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729467 O=C(NC1CCCC1)NC1CCN(CC1)c1ncnc2[nH]ccc12 InChI=1S/C17H24N6O/c24-17(21-12-3-1-2-4-12)22-13-6-9-23(10-7-13)16-14-5-8-18-15(14)19-11-20-16/h5,8,11-13H,1-4,6-7,9-10H2,(H,18,19,20)(H2,21,22,24) GCFLXTKFMCNRTD-UHFFFAOYSA-N 369216 1-cyclopentyl-3-[1-(7H-pyrrolo[2,3- d]pyrimidin-4-yl)-4-piperidyl]urea::US10227357, Compound P-0526 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369216 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369216&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114545 402366012 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729468 CCCC(=O)NC1CCN(CC1)c1ncnc2[nH]ccc12 InChI=1S/C15H21N5O/c1-2-3-13(21)19-11-5-8-20(9-6-11)15-12-4-7-16-14(12)17-10-18-15/h4,7,10-11H,2-3,5-6,8-9H2,1H3,(H,19,21)(H,16,17,18) KXNRYKNHWLMLLJ-UHFFFAOYSA-N 369217 N-[1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)- 4-piperidyl]butanamide::US10227357, Compound P-0527 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369217 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369217&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114418 402366013 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729469 O=C(NC1CCN(CC1)c1ncnc2[nH]ccc12)C1CCCCC1 InChI=1S/C18H25N5O/c24-18(13-4-2-1-3-5-13)22-14-7-10-23(11-8-14)17-15-6-9-19-16(15)20-12-21-17/h6,9,12-14H,1-5,7-8,10-11H2,(H,22,24)(H,19,20,21) NQYXIEKRQOXGDC-UHFFFAOYSA-N 369218 N-[1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)- 4-piperidyl]cyclohexanecarboxamide::US10227357, Compound P-0528 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369218 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369218&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114716 402366014 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729470 O=C(NC1CCN(CC1)c1ncnc2[nH]ccc12)C1CCCC1 InChI=1S/C17H23N5O/c23-17(12-3-1-2-4-12)21-13-6-9-22(10-7-13)16-14-5-8-18-15(14)19-11-20-16/h5,8,11-13H,1-4,6-7,9-10H2,(H,21,23)(H,18,19,20) GJFXAPXTDLCTDL-UHFFFAOYSA-N 369219 N-[1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)- 4-piperidyl]cyclopentanecarboxamide::US10227357, Compound P-0529 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369219 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369219&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114002 402366015 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729471 CCc1ccc(cc1)C(=O)NC1CCN(CC1)c1ncnc2[nH]ccc12 InChI=1S/C20H23N5O/c1-2-14-3-5-15(6-4-14)20(26)24-16-8-11-25(12-9-16)19-17-7-10-21-18(17)22-13-23-19/h3-7,10,13,16H,2,8-9,11-12H2,1H3,(H,24,26)(H,21,22,23) WDSQDEBFUSFPHD-UHFFFAOYSA-N 369220 4-ethyl-N-[1-(7H-pyrrolo[2,3- d]pyrimidin-4-yl)-4- piperidyl]benzamide::US10227357, Compound P-0530 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369220 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369220&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114907 402366016 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729472 O=C(NC1CCN(CC1)c1ncnc2[nH]ccc12)c1ccccc1 InChI=1S/C18H19N5O/c24-18(13-4-2-1-3-5-13)22-14-7-10-23(11-8-14)17-15-6-9-19-16(15)20-12-21-17/h1-6,9,12,14H,7-8,10-11H2,(H,22,24)(H,19,20,21) INORKZBDRVUPDG-UHFFFAOYSA-N 369221 N-[1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)- 4-piperidyl]benzamide::US10227357, Compound P-0531 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369221 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369221&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 57382759 402366017 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729473 CCCS(=O)(=O)NC1CCN(CC1)c1ncnc2[nH]ccc12 InChI=1S/C14H21N5O2S/c1-2-9-22(20,21)18-11-4-7-19(8-5-11)14-12-3-6-15-13(12)16-10-17-14/h3,6,10-11,18H,2,4-5,7-9H2,1H3,(H,15,16,17) CIVKZLJQIAUOQZ-UHFFFAOYSA-N 369222 N-[1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)- 4-piperidyl]propane-1-sulfonamide::US10227357, Compound P-0532 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369222 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369222&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114792 402366018 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729474 O=S(=O)(NC1CCN(CC1)c1ncnc2[nH]ccc12)c1ccccc1 InChI=1S/C17H19N5O2S/c23-25(24,14-4-2-1-3-5-14)21-13-7-10-22(11-8-13)17-15-6-9-18-16(15)19-12-20-17/h1-6,9,12-13,21H,7-8,10-11H2,(H,18,19,20) NJAIQQGJBILJKD-UHFFFAOYSA-N 369223 N-[1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)- 4-piperidyl]benzenesulfonamide::US10227357, Compound P-0533 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369223 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369223&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114289 402366019 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729475 CCOc1ccc(NC(=O)NC2CCN(CC2)c2ncnc3[nH]ccc23)cc1 InChI=1S/C20H24N6O2/c1-2-28-16-5-3-14(4-6-16)24-20(27)25-15-8-11-26(12-9-15)19-17-7-10-21-18(17)22-13-23-19/h3-7,10,13,15H,2,8-9,11-12H2,1H3,(H,21,22,23)(H2,24,25,27) JLPNRVJTRVAGRX-UHFFFAOYSA-N 369224 1-(4-ethoxyphenyl)-3-[1-(7H- pyrrolo[2,3-d]pyrimidin-4-yl)-4- piperidyl]urea::US10227357, Compound P-0534 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369224 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369224&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114772 402366020 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729476 CCc1ccc(NC(=O)NC2CCN(CC2)c2ncnc3[nH]ccc23)cc1 InChI=1S/C20H24N6O/c1-2-14-3-5-15(6-4-14)24-20(27)25-16-8-11-26(12-9-16)19-17-7-10-21-18(17)22-13-23-19/h3-7,10,13,16H,2,8-9,11-12H2,1H3,(H,21,22,23)(H2,24,25,27) NFBROTUDMLZZJY-UHFFFAOYSA-N 369225 1-(4-ethylphenyl)-3-[1-(7H-pyrrolo[2,3- d]pyrimidin-4-yl)-4-piperidyl]urea::US10227357, Compound P-0535 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369225 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369225&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114513 402366021 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729477 CCCNC(=O)NC1CCN(CC1)c1ncnc2[nH]ccc12 InChI=1S/C15H22N6O/c1-2-6-17-15(22)20-11-4-8-21(9-5-11)14-12-3-7-16-13(12)18-10-19-14/h3,7,10-11H,2,4-6,8-9H2,1H3,(H,16,18,19)(H2,17,20,22) SYGGKIYCAPIVOZ-UHFFFAOYSA-N 369226 1-propyl-3-[1-(7H-pyrrolo[2,3- d]pyrimidin-4-yl)-4-piperidyl]urea::US10227357, Compound P-0536 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369226 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369226&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114646 402366022 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729478 O=C(NC1CCCCC1)NC1CCN(CC1)c1ncnc2[nH]ccc12 InChI=1S/C18H26N6O/c25-18(22-13-4-2-1-3-5-13)23-14-7-10-24(11-8-14)17-15-6-9-19-16(15)20-12-21-17/h6,9,12-14H,1-5,7-8,10-11H2,(H,19,20,21)(H2,22,23,25) BMDMUWZXBIKSNX-UHFFFAOYSA-N 369227 1-cyclohexyl-3-[1-(7H-pyrrolo[2,3- d]pyrimidin-4-yl)-4-piperidyl]urea::US10227357, Compound P-0537 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369227 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369227&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114719 402366023 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729479 O=C(NC1CCN(CC1)c1ncnc2[nH]ccc12)Nc1ccccc1 InChI=1S/C18H20N6O/c25-18(22-13-4-2-1-3-5-13)23-14-7-10-24(11-8-14)17-15-6-9-19-16(15)20-12-21-17/h1-6,9,12,14H,7-8,10-11H2,(H,19,20,21)(H2,22,23,25) OZLBNJFVMUTJHR-UHFFFAOYSA-N 369228 1-phenyl-3-[1-(7H-pyrrolo[2,3- d]pyrimidin-4-yl)-4-piperidyl]urea::US10227357, Compound P-0538 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369228 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369228&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114518 402366024 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729480 Fc1ccc(F)c(c1)S(=O)(=O)NC1CCN(CC1)c1ncnc2[nH]ccc12 InChI=1S/C17H17F2N5O2S/c18-11-1-2-14(19)15(9-11)27(25,26)23-12-4-7-24(8-5-12)17-13-3-6-20-16(13)21-10-22-17/h1-3,6,9-10,12,23H,4-5,7-8H2,(H,20,21,22) DDBUVPMGHUEADP-UHFFFAOYSA-N 369229 2,5-difluoro-N-[1-(7H-pyrrolo[2,3- d]pyrimidin-4-yl)-4- piperidyl]benzenesulfonamide::US10227357, Compound P-0539 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369229 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369229&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114188 402366025 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729481 Fc1ccc(F)c(c1)S(=O)(=O)NC1CCN(CC1)c1ncnc2[nH]ccc12 InChI=1S/C17H17F2N5O2S/c18-11-1-2-14(19)15(9-11)27(25,26)23-12-4-7-24(8-5-12)17-13-3-6-20-16(13)21-10-22-17/h1-3,6,9-10,12,23H,4-5,7-8H2,(H,20,21,22) DDBUVPMGHUEADP-UHFFFAOYSA-N 369229 2,5-difluoro-N-[1-(7H-pyrrolo[2,3- d]pyrimidin-4-yl)-4- piperidyl]benzenesulfonamide::US10227357, Compound P-0539 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369229 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369229&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114188 402366025 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729482 COc1ccc(cc1)S(=O)(=O)NC1CCN(CC1)c1ncnc2[nH]ccc12 InChI=1S/C18H21N5O3S/c1-26-14-2-4-15(5-3-14)27(24,25)22-13-7-10-23(11-8-13)18-16-6-9-19-17(16)20-12-21-18/h2-6,9,12-13,22H,7-8,10-11H2,1H3,(H,19,20,21) AWMGVJOJXQKLQN-UHFFFAOYSA-N 369230 4-methoxy-N-[1-(7H-pyrrolo[2,3- d]pyrimidin-4-yl)-4- piperidyl]benzenesulfonamide::US10227357, Compound P-0540 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369230 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369230&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114399 402366026 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729483 COc1ccc(cc1)S(=O)(=O)NC1CCN(CC1)c1ncnc2[nH]ccc12 InChI=1S/C18H21N5O3S/c1-26-14-2-4-15(5-3-14)27(24,25)22-13-7-10-23(11-8-13)18-16-6-9-19-17(16)20-12-21-18/h2-6,9,12-13,22H,7-8,10-11H2,1H3,(H,19,20,21) AWMGVJOJXQKLQN-UHFFFAOYSA-N 369230 4-methoxy-N-[1-(7H-pyrrolo[2,3- d]pyrimidin-4-yl)-4- piperidyl]benzenesulfonamide::US10227357, Compound P-0540 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369230 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369230&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114399 402366026 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729484 NC1CCN(CC1)c1ncnc2[nH]ccc12 InChI=1S/C11H15N5/c12-8-2-5-16(6-3-8)11-9-1-4-13-10(9)14-7-15-11/h1,4,7-8H,2-3,5-6,12H2,(H,13,14,15) SOYJTCRGELSHIV-UHFFFAOYSA-N 50376057 CHEMBL259141::US10227357, Compound P-0541 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50376057 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50376057&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 11564772 160855147 CHEMBL259141 ZINC29050945 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729485 NC1CCN(CC1)c1ncnc2[nH]ccc12 InChI=1S/C11H15N5/c12-8-2-5-16(6-3-8)11-9-1-4-13-10(9)14-7-15-11/h1,4,7-8H,2-3,5-6,12H2,(H,13,14,15) SOYJTCRGELSHIV-UHFFFAOYSA-N 50376057 CHEMBL259141::US10227357, Compound P-0541 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50376057 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50376057&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 11564772 160855147 CHEMBL259141 ZINC29050945 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729486 COc1ccc(NC(=O)NC2CCN(CC2)c2ncnc3[nH]ccc23)cc1 InChI=1S/C19H22N6O2/c1-27-15-4-2-13(3-5-15)23-19(26)24-14-7-10-25(11-8-14)18-16-6-9-20-17(16)21-12-22-18/h2-6,9,12,14H,7-8,10-11H2,1H3,(H,20,21,22)(H2,23,24,26) WZSCHZSOWCNCDP-UHFFFAOYSA-N 369232 1-(4-methoxyphenyl)-3-[1-(7H- pyrrolo[2,3-d]pyrimidin-4-yl)-4- piperidyl]urea::US10227357, Compound P-0543 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369232 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369232&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90000829 402366028 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729487 COc1ccc(NC(=O)NC2CCN(CC2)c2ncnc3[nH]ccc23)cc1 InChI=1S/C19H22N6O2/c1-27-15-4-2-13(3-5-15)23-19(26)24-14-7-10-25(11-8-14)18-16-6-9-20-17(16)21-12-22-18/h2-6,9,12,14H,7-8,10-11H2,1H3,(H,20,21,22)(H2,23,24,26) WZSCHZSOWCNCDP-UHFFFAOYSA-N 369232 1-(4-methoxyphenyl)-3-[1-(7H- pyrrolo[2,3-d]pyrimidin-4-yl)-4- piperidyl]urea::US10227357, Compound P-0543 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369232 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369232&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90000829 402366028 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729488 Cc1ccc(cn1)-c1cc2c(ncnc2[nH]1)C1=CCC(CC1)NS(=O)(=O)c1ccc(OC(F)(F)F)cc1 369017 N-[4-[6-(6-methyl-3-pyridyl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]cyclohex-3- en-1-yl]-4- (trifluoromethoxy)benzenesulfonamide::US10227357, Compound P-0281::US10227357, Compound P-0544 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369017&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114519 402365815 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729489 Cn1cc(cn1)-c1cc2c(ncnc2[nH]1)C1=CCC(CC1)NS(=O)(=O)c1ccc(OC(F)(F)F)cc1 369021 N-[4-[6-(1-methylpyrazol-4-yl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]cyclohex-3- en-1-yl]-4- (trifluoromethoxy)benzenesulfonamide::US10227357, Compound P-0285::US10227357, Compound P-0545 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369021 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369021&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115480 402365819 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729490 Fc1ccc(NC(=O)N2CC3CCC2CN3c2ncnc3cc(sc23)-c2ccc(F)cc2)cc1 InChI=1S/C25H21F2N5OS/c26-16-3-1-15(2-4-16)22-11-21-23(34-22)24(29-14-28-21)31-12-20-10-9-19(31)13-32(20)25(33)30-18-7-5-17(27)6-8-18/h1-8,11,14,19-20H,9-10,12-13H2,(H,30,33) BPYUPCDDEWEKKU-UHFFFAOYSA-N 369235 N-(4-fluorophenyl)-5-[6-(4- fluorophenyl)thieno[3,2-d]pyrimidin-4-yl]- 2,5-diazabicyclo[2.2.2]octane-2- carboxamide::US10227357, Compound P-0546 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369235 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369235&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90001319 402366029 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729491 COc1cccc(CNC(=O)N2CC3CCC2CN3c2ncnc3cc(sc23)-c2ccc(F)cc2)c1 InChI=1S/C27H26FN5O2S/c1-35-22-4-2-3-17(11-22)13-29-27(34)33-15-20-9-10-21(33)14-32(20)26-25-23(30-16-31-26)12-24(36-25)18-5-7-19(28)8-6-18/h2-8,11-12,16,20-21H,9-10,13-15H2,1H3,(H,29,34) GZWMMXHIZATIGL-UHFFFAOYSA-N 369236 5-[6-(4-fluorophenyl)thieno[3,2- d]pyrimidin-4-yl]-N-[(3- methoxyphenyl)methyl]-2,5- diazabicyclo[2.2.2]octane-2-carboxamide::US10227357, Compound P-0547 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369236 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369236&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90001218 402366030 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729492 COc1cccc(c1)[C@H](C)NC(=O)N1CCN(CC1)c1ncnc2cc(sc12)N1CCOCC1 InChI=1S/C24H30N6O3S/c1-17(18-4-3-5-19(14-18)32-2)27-24(31)30-8-6-29(7-9-30)23-22-20(25-16-26-23)15-21(34-22)28-10-12-33-13-11-28/h3-5,14-17H,6-13H2,1-2H3,(H,27,31)/t17-/m0/s1 WQQVKWGDCXPMGS-KRWDZBQOSA-N 369237 N-[(1S)-1-(3-methoxyphenyl)ethyl]-4-(6- morpholinothieno[3,2-d]pyrimidin-4- yl)piperazine-1-carboxamide::US10227357, Compound P-0548 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369237 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369237&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 86718058 402366031 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729493 COc1cccc(c1)[C@H](C)NC(=O)N1CC2CCC(C1)N2c1ncnc2cc(sc12)-c1ccc(F)cc1 InChI=1S/C28H28FN5O2S/c1-17(19-4-3-5-23(12-19)36-2)32-28(35)33-14-21-10-11-22(15-33)34(21)27-26-24(30-16-31-27)13-25(37-26)18-6-8-20(29)9-7-18/h3-9,12-13,16-17,21-22H,10-11,14-15H2,1-2H3,(H,32,35)/t17-,21?,22?/m0/s1 MLOSFSQWUUCPPF-YTXWROIDSA-N 369238 8-[6-(4-fluorophenyl)thieno[3,2- d]pyrimidin-4-yl]-N-[(1S)-1-(3- methoxyphenyl)ethyl]-3,8- diazabicyclo[3.2.1]octane-3-carboxamide::US10227357, Compound P-0550 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369238 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369238&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115206 402366032 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729494 COc1cccc(CNC(=O)N2CC3CCC(C2)N3c2ncnc3cc(sc23)-c2ccc(F)cc2)c1 InChI=1S/C27H26FN5O2S/c1-35-22-4-2-3-17(11-22)13-29-27(34)32-14-20-9-10-21(15-32)33(20)26-25-23(30-16-31-26)12-24(36-25)18-5-7-19(28)8-6-18/h2-8,11-12,16,20-21H,9-10,13-15H2,1H3,(H,29,34) NQPMVIINVDHPCD-UHFFFAOYSA-N 369239 8-[6-(4-fluorophenyl)thieno[3,2- d]pyrimidin-4-yl]-N-[(3- methoxyphenyl)methyl]-3,8- diazabicyclo[3.2.1]octane-3-carboxamide::US10227357, Compound P-0551 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369239 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369239&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90001621 402366033 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729495 C[C@H](NC(=O)N1CCN(CC1(C)C)c1ncnc2cc(sc12)C1=CCN(CC1)C(=O)C1CC1)c1cccc(Cl)c1 InChI=1S/C30H35ClN6O2S/c1-19(22-5-4-6-23(31)15-22)34-29(39)37-14-13-36(17-30(37,2)3)27-26-24(32-18-33-27)16-25(40-26)20-9-11-35(12-10-20)28(38)21-7-8-21/h4-6,9,15-16,18-19,21H,7-8,10-14,17H2,1-3H3,(H,34,39)/t19-/m0/s1 SNNQBHYLIVZWNM-IBGZPJMESA-N 369240 N-[(1S)-1-(3-chlorophenyl)ethyl]-4-[6-[1- (cyclopropanecarbonyl)-3,6-dihydro-2H- pyridin-4-yl]thieno[3,2-d]pyrimidin-4-yl]- 2,2-dimethyl-piperazine-1-carboxamide::US10227357, Compound P-0552 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369240 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369240&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 89994044 402366034 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729496 C[C@H](NC(=O)N1CCN(CC1(C)C)c1ncnc2cc(sc12)C1=CCN(CC1)C(=O)C1CC1)c1cccc(Cl)c1 InChI=1S/C30H35ClN6O2S/c1-19(22-5-4-6-23(31)15-22)34-29(39)37-14-13-36(17-30(37,2)3)27-26-24(32-18-33-27)16-25(40-26)20-9-11-35(12-10-20)28(38)21-7-8-21/h4-6,9,15-16,18-19,21H,7-8,10-14,17H2,1-3H3,(H,34,39)/t19-/m0/s1 SNNQBHYLIVZWNM-IBGZPJMESA-N 369240 N-[(1S)-1-(3-chlorophenyl)ethyl]-4-[6-[1- (cyclopropanecarbonyl)-3,6-dihydro-2H- pyridin-4-yl]thieno[3,2-d]pyrimidin-4-yl]- 2,2-dimethyl-piperazine-1-carboxamide::US10227357, Compound P-0552 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369240 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369240&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 89994044 402366034 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729497 C[C@H](NC(=O)N1CCN(CC1(C)C)c1ncnc2cc(sc12)C1=CCN(CC1)S(C)(=O)=O)c1cccc(Cl)c1 InChI=1S/C27H33ClN6O3S2/c1-18(20-6-5-7-21(28)14-20)31-26(35)34-13-12-32(16-27(34,2)3)25-24-22(29-17-30-25)15-23(38-24)19-8-10-33(11-9-19)39(4,36)37/h5-8,14-15,17-18H,9-13,16H2,1-4H3,(H,31,35)/t18-/m0/s1 KEJXJNLVWCGQQM-SFHVURJKSA-N 369241 N-[(1S)-1-(3-chlorophenyl)ethyl]-2,2- dimethyl-4-[6-(1-methylsulfonyl-3,6- dihydro-2H-pyridin-4-yl)thieno[3,2- d]pyrimidin-4-yl]piperazine-1- carboxamide::US10227357, Compound P-0553 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369241 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369241&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 86718088 402366035 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729498 C[C@H](NC(=O)N1CCN(CC1(C)C)c1ncnc2cc(sc12)C1=CCN(CC1)S(C)(=O)=O)c1cccc(Cl)c1 InChI=1S/C27H33ClN6O3S2/c1-18(20-6-5-7-21(28)14-20)31-26(35)34-13-12-32(16-27(34,2)3)25-24-22(29-17-30-25)15-23(38-24)19-8-10-33(11-9-19)39(4,36)37/h5-8,14-15,17-18H,9-13,16H2,1-4H3,(H,31,35)/t18-/m0/s1 KEJXJNLVWCGQQM-SFHVURJKSA-N 369241 N-[(1S)-1-(3-chlorophenyl)ethyl]-2,2- dimethyl-4-[6-(1-methylsulfonyl-3,6- dihydro-2H-pyridin-4-yl)thieno[3,2- d]pyrimidin-4-yl]piperazine-1- carboxamide::US10227357, Compound P-0553 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369241 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369241&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 86718088 402366035 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729499 O=C(N1CCOCC1)N1CCC(=CC1)c1cc2ncnc(-c3ccc(NS(=O)(=O)C4CC4)cc3)c2s1 InChI=1S/C25H27N5O4S2/c31-25(30-11-13-34-14-12-30)29-9-7-17(8-10-29)22-15-21-24(35-22)23(27-16-26-21)18-1-3-19(4-2-18)28-36(32,33)20-5-6-20/h1-4,7,15-16,20,28H,5-6,8-14H2 NSQCUHHYKITQHV-UHFFFAOYSA-N 369242 N-[4-[6-[1-(morpholine-4-carbonyl)-3,6- dihydro-2H-pyridin-4-yl]thieno[3,2- d]pyrimidin-4- yl]phenyl]cyclopropanesulfonamide::US10227357, Compound P-0554 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369242 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369242&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 86718096 402366036 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729500 O=C(N1CCOCC1)N1CCC(=CC1)c1cc2ncnc(-c3ccc(NS(=O)(=O)C4CC4)cc3)c2s1 InChI=1S/C25H27N5O4S2/c31-25(30-11-13-34-14-12-30)29-9-7-17(8-10-29)22-15-21-24(35-22)23(27-16-26-21)18-1-3-19(4-2-18)28-36(32,33)20-5-6-20/h1-4,7,15-16,20,28H,5-6,8-14H2 NSQCUHHYKITQHV-UHFFFAOYSA-N 369242 N-[4-[6-[1-(morpholine-4-carbonyl)-3,6- dihydro-2H-pyridin-4-yl]thieno[3,2- d]pyrimidin-4- yl]phenyl]cyclopropanesulfonamide::US10227357, Compound P-0554 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369242 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369242&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 86718096 402366036 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729501 CS(=O)(=O)Nc1ccc(cc1)-c1ncnc2cc(sc12)C1=CCN(CC1)C(=O)N1CCOCC1 InChI=1S/C23H25N5O4S2/c1-34(30,31)26-18-4-2-17(3-5-18)21-22-19(24-15-25-21)14-20(33-22)16-6-8-27(9-7-16)23(29)28-10-12-32-13-11-28/h2-6,14-15,26H,7-13H2,1H3 RENYQNFGULXZMQ-UHFFFAOYSA-N 369243 N-[4-[6-[1-(morpholine-4-carbonyl)-3,6- dihydro-2H-pyridin-4-yl]thieno[3,2- d]pyrimidin-4- yl]phenyl]methanesulfonamide::US10227357, Compound P-0555 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369243 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369243&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 86718095 402366037 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729502 CS(=O)(=O)Nc1ccc(cc1)-c1ncnc2cc(sc12)C1=CCN(CC1)C(=O)N1CCOCC1 InChI=1S/C23H25N5O4S2/c1-34(30,31)26-18-4-2-17(3-5-18)21-22-19(24-15-25-21)14-20(33-22)16-6-8-27(9-7-16)23(29)28-10-12-32-13-11-28/h2-6,14-15,26H,7-13H2,1H3 RENYQNFGULXZMQ-UHFFFAOYSA-N 369243 N-[4-[6-[1-(morpholine-4-carbonyl)-3,6- dihydro-2H-pyridin-4-yl]thieno[3,2- d]pyrimidin-4- yl]phenyl]methanesulfonamide::US10227357, Compound P-0555 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369243 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369243&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 86718095 402366037 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729503 COc1cc(ccn1)-c1cc2ncnc(N3CCN(C(=O)N[C@@H](C)c4cccc(Cl)c4)C(C)(C)C3)c2s1 InChI=1S/C27H29ClN6O2S/c1-17(18-6-5-7-20(28)12-18)32-26(35)34-11-10-33(15-27(34,2)3)25-24-21(30-16-31-25)14-22(37-24)19-8-9-29-23(13-19)36-4/h5-9,12-14,16-17H,10-11,15H2,1-4H3,(H,32,35)/t17-/m0/s1 WRULVEWNDYFGEE-KRWDZBQOSA-N 369244 N-[(1S)-1-(3-chlorophenyl)ethyl]-4-[6-(2- methoxy-4-pyridyl)thieno[3,2- d]pyrimidin-4-yl]-2,2-dimethyl-piperazine- 1-carboxamide::US10227357, Compound P-0556 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369244 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369244&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 86718084 402366038 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729504 COc1cc(ccn1)-c1cc2ncnc(N3CCN(C(=O)N[C@@H](C)c4cccc(Cl)c4)C(C)(C)C3)c2s1 InChI=1S/C27H29ClN6O2S/c1-17(18-6-5-7-20(28)12-18)32-26(35)34-11-10-33(15-27(34,2)3)25-24-21(30-16-31-25)14-22(37-24)19-8-9-29-23(13-19)36-4/h5-9,12-14,16-17H,10-11,15H2,1-4H3,(H,32,35)/t17-/m0/s1 WRULVEWNDYFGEE-KRWDZBQOSA-N 369244 N-[(1S)-1-(3-chlorophenyl)ethyl]-4-[6-(2- methoxy-4-pyridyl)thieno[3,2- d]pyrimidin-4-yl]-2,2-dimethyl-piperazine- 1-carboxamide::US10227357, Compound P-0556 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369244 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369244&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 86718084 402366038 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729505 C[C@H](NC(=O)N1CCN(CC1(C)C)c1ncnc2cc(sc12)-c1sc(C)nc1C)c1cccc(Cl)c1 InChI=1S/C26H29ClN6OS2/c1-15(18-7-6-8-19(27)11-18)31-25(34)33-10-9-32(13-26(33,4)5)24-23-20(28-14-29-24)12-21(36-23)22-16(2)30-17(3)35-22/h6-8,11-12,14-15H,9-10,13H2,1-5H3,(H,31,34)/t15-/m0/s1 GTANCZJBDPCXNF-HNNXBMFYSA-N 369245 N-[(1S)-1-(3-chlorophenyl)ethyl]-4-[6-(2,4- dimethylthiazol-5-yl)thieno[3,2- d]pyrimidin-4-yl]-2,2-dimethyl-piperazine- 1-carboxamide::US10227357, Compound P-0557 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369245 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369245&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115101 402366039 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729506 C[C@H](NC(=O)N1CCN(CC1(C)C)c1ncnc2cc(sc12)-c1sc(C)nc1C)c1cccc(Cl)c1 InChI=1S/C26H29ClN6OS2/c1-15(18-7-6-8-19(27)11-18)31-25(34)33-10-9-32(13-26(33,4)5)24-23-20(28-14-29-24)12-21(36-23)22-16(2)30-17(3)35-22/h6-8,11-12,14-15H,9-10,13H2,1-5H3,(H,31,34)/t15-/m0/s1 GTANCZJBDPCXNF-HNNXBMFYSA-N 369245 N-[(1S)-1-(3-chlorophenyl)ethyl]-4-[6-(2,4- dimethylthiazol-5-yl)thieno[3,2- d]pyrimidin-4-yl]-2,2-dimethyl-piperazine- 1-carboxamide::US10227357, Compound P-0557 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369245 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369245&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115101 402366039 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729507 C[C@H](NC(=O)N1CCN(CC1(C)C)c1ncnc2cc(sc12)N1CCOCC1)c1cccc(Cl)c1 InChI=1S/C25H31ClN6O2S/c1-17(18-5-4-6-19(26)13-18)29-24(33)32-8-7-31(15-25(32,2)3)23-22-20(27-16-28-23)14-21(35-22)30-9-11-34-12-10-30/h4-6,13-14,16-17H,7-12,15H2,1-3H3,(H,29,33)/t17-/m0/s1 DYGWGIKOFNLPSU-KRWDZBQOSA-N 369246 N-[(1S)-1-(3-chlorophenyl)ethyl]-2,2- dimethyl-4-(6-morpholinothieno[3,2- d]pyrimidin-4-yl)piperazine-1- carboxamide::US10227357, Compound P-0558 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369246 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369246&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114753 402366040 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729508 C[C@H](NC(=O)N1CCN(CC1(C)C)c1ncnc2cc(sc12)N1CCOCC1)c1cccc(Cl)c1 InChI=1S/C25H31ClN6O2S/c1-17(18-5-4-6-19(26)13-18)29-24(33)32-8-7-31(15-25(32,2)3)23-22-20(27-16-28-23)14-21(35-22)30-9-11-34-12-10-30/h4-6,13-14,16-17H,7-12,15H2,1-3H3,(H,29,33)/t17-/m0/s1 DYGWGIKOFNLPSU-KRWDZBQOSA-N 369246 N-[(1S)-1-(3-chlorophenyl)ethyl]-2,2- dimethyl-4-(6-morpholinothieno[3,2- d]pyrimidin-4-yl)piperazine-1- carboxamide::US10227357, Compound P-0558 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369246 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369246&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114753 402366040 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729509 CC(=N)Nc1ccc(cc1)-c1ncnc2cc(sc12)C1=CCN(CC1)C(=O)N1CCOCC1 InChI=1S/C24H26N6O2S/c1-16(25)28-19-4-2-18(3-5-19)22-23-20(26-15-27-22)14-21(33-23)17-6-8-29(9-7-17)24(31)30-10-12-32-13-11-30/h2-6,14-15H,7-13H2,1H3,(H2,25,28) GDLOTUOQZJRLKZ-UHFFFAOYSA-N 369247 N-[4-[6-[1-(morpholine-4-carbonyl)-3,6- dihydro-2H-pyridin-4-yl]thieno[3,2- d]pyrimidin-4-yl]phenyl]acetamidine::US10227357, Compound P-0559 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369247 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369247&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114083 402366041 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729510 CC(=N)Nc1ccc(cc1)-c1ncnc2cc(sc12)C1=CCN(CC1)C(=O)N1CCOCC1 InChI=1S/C24H26N6O2S/c1-16(25)28-19-4-2-18(3-5-19)22-23-20(26-15-27-22)14-21(33-23)17-6-8-29(9-7-17)24(31)30-10-12-32-13-11-30/h2-6,14-15H,7-13H2,1H3,(H2,25,28) GDLOTUOQZJRLKZ-UHFFFAOYSA-N 369247 N-[4-[6-[1-(morpholine-4-carbonyl)-3,6- dihydro-2H-pyridin-4-yl]thieno[3,2- d]pyrimidin-4-yl]phenyl]acetamidine::US10227357, Compound P-0559 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369247 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369247&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114083 402366041 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729511 COc1cccc(c1)[C@H](C)NC(=O)N1CCN(CC1(C)C)c1ncnc2cc(sc12)N1CCOCC1 InChI=1S/C26H34N6O3S/c1-18(19-6-5-7-20(14-19)34-4)29-25(33)32-9-8-31(16-26(32,2)3)24-23-21(27-17-28-24)15-22(36-23)30-10-12-35-13-11-30/h5-7,14-15,17-18H,8-13,16H2,1-4H3,(H,29,33)/t18-/m0/s1 RFKUGORXDIQBCE-SFHVURJKSA-N 369248 N-[(1S)-1-(3-methoxyphenyl)ethyl]-2,2- dimethyl-4-(6-morpholinothieno[3,2- d]pyrimidin-4-yl)piperazine-1- carboxamide::US10227357, Compound P-0560 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369248 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369248&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114570 402366042 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729512 COc1cccc(c1)[C@H](C)NC(=O)N1CCN(CC1(C)C)c1ncnc2cc(sc12)N1CCOCC1 InChI=1S/C26H34N6O3S/c1-18(19-6-5-7-20(14-19)34-4)29-25(33)32-9-8-31(16-26(32,2)3)24-23-21(27-17-28-24)15-22(36-23)30-10-12-35-13-11-30/h5-7,14-15,17-18H,8-13,16H2,1-4H3,(H,29,33)/t18-/m0/s1 RFKUGORXDIQBCE-SFHVURJKSA-N 369248 N-[(1S)-1-(3-methoxyphenyl)ethyl]-2,2- dimethyl-4-(6-morpholinothieno[3,2- d]pyrimidin-4-yl)piperazine-1- carboxamide::US10227357, Compound P-0560 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369248 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369248&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114570 402366042 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729513 Fc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)-c1ncnc2cc(sc12)C1=CCN(CC1)C(=O)N1CCOCC1 InChI=1S/C28H26FN5O4S2/c29-21-3-7-23(8-4-21)40(36,37)32-22-5-1-20(2-6-22)26-27-24(30-18-31-26)17-25(39-27)19-9-11-33(12-10-19)28(35)34-13-15-38-16-14-34/h1-9,17-18,32H,10-16H2 BCPMYQDTNLZKAM-UHFFFAOYSA-N 369249 4-fluoro-N-[4-[6-[1-(morpholine-4- carbonyl)-3,6-dihydro-2H-pyridin-4- yl]thieno[3,2-d]pyrimidin-4- yl]phenyl]benzenesulfonamide::US10227357, Compound P-0561 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369249 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369249&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 86718094 402366043 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729514 Fc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)-c1ncnc2cc(sc12)C1=CCN(CC1)C(=O)N1CCOCC1 InChI=1S/C28H26FN5O4S2/c29-21-3-7-23(8-4-21)40(36,37)32-22-5-1-20(2-6-22)26-27-24(30-18-31-26)17-25(39-27)19-9-11-33(12-10-19)28(35)34-13-15-38-16-14-34/h1-9,17-18,32H,10-16H2 BCPMYQDTNLZKAM-UHFFFAOYSA-N 369249 4-fluoro-N-[4-[6-[1-(morpholine-4- carbonyl)-3,6-dihydro-2H-pyridin-4- yl]thieno[3,2-d]pyrimidin-4- yl]phenyl]benzenesulfonamide::US10227357, Compound P-0561 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369249 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369249&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 86718094 402366043 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729515 C[C@H](NC(=O)N1CCN(CC1(C)C)c1ncnc2cc(sc12)-c1cn(C)nc1C)c1cccc(Cl)c1 InChI=1S/C26H30ClN7OS/c1-16(18-7-6-8-19(27)11-18)30-25(35)34-10-9-33(14-26(34,3)4)24-23-21(28-15-29-24)12-22(36-23)20-13-32(5)31-17(20)2/h6-8,11-13,15-16H,9-10,14H2,1-5H3,(H,30,35)/t16-/m0/s1 MHTQREFGDTVSNT-INIZCTEOSA-N 369250 N-[(1S)-1-(3-chlorophenyl)ethyl]-4-[6-(1,3- dimethylpyrazol-4-yl)thieno[3,2- d]pyrimidin-4-yl]-2,2-dimethyl-piperazine- 1-carboxamide::US10227357, Compound P-0564 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369250 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369250&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90003936 402366044 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729516 C[C@H](NC(=O)N1CCN(CC1(C)C)c1ncnc2cc(sc12)-c1cn(C)nc1C)c1cccc(Cl)c1 InChI=1S/C26H30ClN7OS/c1-16(18-7-6-8-19(27)11-18)30-25(35)34-10-9-33(14-26(34,3)4)24-23-21(28-15-29-24)12-22(36-23)20-13-32(5)31-17(20)2/h6-8,11-13,15-16H,9-10,14H2,1-5H3,(H,30,35)/t16-/m0/s1 MHTQREFGDTVSNT-INIZCTEOSA-N 369250 N-[(1S)-1-(3-chlorophenyl)ethyl]-4-[6-(1,3- dimethylpyrazol-4-yl)thieno[3,2- d]pyrimidin-4-yl]-2,2-dimethyl-piperazine- 1-carboxamide::US10227357, Compound P-0564 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369250 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369250&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90003936 402366044 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729517 C[C@H](NC(=O)N1CC2CCC1CN2c1ncnc2cc(sc12)-c1ccc(F)cc1)c1cccc(Cl)c1 InChI=1S/C27H25ClFN5OS/c1-16(18-3-2-4-19(28)11-18)32-27(35)34-14-21-9-10-22(34)13-33(21)26-25-23(30-15-31-26)12-24(36-25)17-5-7-20(29)8-6-17/h2-8,11-12,15-16,21-22H,9-10,13-14H2,1H3,(H,32,35)/t16-,21?,22?/m0/s1 MIWIMKGLYSIIPZ-XDGVHFHYSA-N 369251 N-[(1S)-1-(3-chlorophenyl)ethyl]-5-[6-(4- fluorophenyl)thieno[3,2-d]pyrimidin-4-yl]- 2,5-diazabicyclo[2.2.2]octane-2- carboxamide::US10227357, Compound P-0565 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369251 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369251&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114901 402366045 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729518 COc1cccc(c1)[C@H](C)NC(=O)N1CC2CCC1CN2c1ncnc2cc(sc12)-c1ccc(F)cc1 InChI=1S/C28H28FN5O2S/c1-17(19-4-3-5-23(12-19)36-2)32-28(35)34-15-21-10-11-22(34)14-33(21)27-26-24(30-16-31-27)13-25(37-26)18-6-8-20(29)9-7-18/h3-9,12-13,16-17,21-22H,10-11,14-15H2,1-2H3,(H,32,35)/t17-,21?,22?/m0/s1 OXXGZHSUVQRAKN-YTXWROIDSA-N 369252 5-[6-(4-fluorophenyl)thieno[3,2- d]pyrimidin-4-yl]-N-[(1S)-1-(3- methoxyphenyl)ethyl]-2,5- diazabicyclo[2.2.2]octane-2-carboxamide::US10227357, Compound P-0566 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369252 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369252&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114797 402366046 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729519 COc1cccc(c1)[C@H](C)NC(=O)N1CC2CCC1CN2c1ncnc2cc(sc12)-c1ccc(F)cc1 InChI=1S/C28H28FN5O2S/c1-17(19-4-3-5-23(12-19)36-2)32-28(35)34-15-21-10-11-22(34)14-33(21)27-26-24(30-16-31-27)13-25(37-26)18-6-8-20(29)9-7-18/h3-9,12-13,16-17,21-22H,10-11,14-15H2,1-2H3,(H,32,35)/t17-,21?,22?/m0/s1 OXXGZHSUVQRAKN-YTXWROIDSA-N 369252 5-[6-(4-fluorophenyl)thieno[3,2- d]pyrimidin-4-yl]-N-[(1S)-1-(3- methoxyphenyl)ethyl]-2,5- diazabicyclo[2.2.2]octane-2-carboxamide::US10227357, Compound P-0566 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369252 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369252&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114797 402366046 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729520 COc1cccc(c1)[C@H](C)NC(=O)N1C2CCC1CN(C2)c1ncnc2cc(sc12)-c1ccc(F)cc1 InChI=1S/C28H28FN5O2S/c1-17(19-4-3-5-23(12-19)36-2)32-28(35)34-21-10-11-22(34)15-33(14-21)27-26-24(30-16-31-27)13-25(37-26)18-6-8-20(29)9-7-18/h3-9,12-13,16-17,21-22H,10-11,14-15H2,1-2H3,(H,32,35)/t17-,21?,22?/m0/s1 FKJKEKKFAAAJHX-YTXWROIDSA-N 369253 3-[6-(4-fluorophenyl)thieno[3,2- d]pyrimidin-4-yl]-N-[(1S)-1-(3- methoxyphenyl)ethyl]-3,8- diazabicyclo[3.2.1]octane-8-carboxamide::US10227357, Compound P-0567 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369253 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369253&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114532 402366047 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729521 COc1cccc(c1)[C@H](C)NC(=O)N1C2CCC1CN(C2)c1ncnc2cc(sc12)-c1ccc(F)cc1 InChI=1S/C28H28FN5O2S/c1-17(19-4-3-5-23(12-19)36-2)32-28(35)34-21-10-11-22(34)15-33(14-21)27-26-24(30-16-31-27)13-25(37-26)18-6-8-20(29)9-7-18/h3-9,12-13,16-17,21-22H,10-11,14-15H2,1-2H3,(H,32,35)/t17-,21?,22?/m0/s1 FKJKEKKFAAAJHX-YTXWROIDSA-N 369253 3-[6-(4-fluorophenyl)thieno[3,2- d]pyrimidin-4-yl]-N-[(1S)-1-(3- methoxyphenyl)ethyl]-3,8- diazabicyclo[3.2.1]octane-8-carboxamide::US10227357, Compound P-0567 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369253 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369253&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114532 402366047 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729522 CS(=O)(=O)N1CCC(=CC1)c1cc2ncnc(N3CCN(CC3)C(=O)NCc3ccc(F)cc3)c2s1 InChI=1S/C24H27FN6O3S2/c1-36(33,34)31-8-6-18(7-9-31)21-14-20-22(35-21)23(28-16-27-20)29-10-12-30(13-11-29)24(32)26-15-17-2-4-19(25)5-3-17/h2-6,14,16H,7-13,15H2,1H3,(H,26,32) LHMWQPDWCWXZJM-UHFFFAOYSA-N 369254 N-[(4-fluorophenyl)methyl]-4-[6-(1- methylsulfonyl-3,6-dihydro-2H-pyridin-4- yl)thieno[3,2-d]pyrimidin-4-yl]piperazine- 1-carboxamide::US10227357, Compound P-0568 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369254 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369254&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114535 402366048 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729523 CS(=O)(=O)N1CCC(=CC1)c1cc2ncnc(N3CCN(CC3)C(=O)NCc3ccc(F)cc3)c2s1 InChI=1S/C24H27FN6O3S2/c1-36(33,34)31-8-6-18(7-9-31)21-14-20-22(35-21)23(28-16-27-20)29-10-12-30(13-11-29)24(32)26-15-17-2-4-19(25)5-3-17/h2-6,14,16H,7-13,15H2,1H3,(H,26,32) LHMWQPDWCWXZJM-UHFFFAOYSA-N 369254 N-[(4-fluorophenyl)methyl]-4-[6-(1- methylsulfonyl-3,6-dihydro-2H-pyridin-4- yl)thieno[3,2-d]pyrimidin-4-yl]piperazine- 1-carboxamide::US10227357, Compound P-0568 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369254 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369254&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114535 402366048 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729524 C[C@H](NC(=O)N1CCN(CC1)c1ncnc2cc(sc12)C1=CC(C)(C)NC(C)(C)C1)c1cccc(Cl)c1 InChI=1S/C28H35ClN6OS/c1-18(19-7-6-8-21(29)13-19)32-26(36)35-11-9-34(10-12-35)25-24-22(30-17-31-25)14-23(37-24)20-15-27(2,3)33-28(4,5)16-20/h6-8,13-15,17-18,33H,9-12,16H2,1-5H3,(H,32,36)/t18-/m0/s1 HIRNPSJKSHGRSC-SFHVURJKSA-N 369255 N-[(1S)-1-(3-chlorophenyl)ethyl]-4-[6- (2,2,6,6-tetramethyl-1,3-dihydropyridin-4- yl)thieno[3,2-d]pyrimidin-4-yl]piperazine- 1-carboxamide::US10227357, Compound P-0569 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369255 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369255&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 86718081 402366049 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729525 C[C@H](NC(=O)N1CCN(CC1)c1ncnc2cc(sc12)C1=CC(C)(C)NC(C)(C)C1)c1cccc(Cl)c1 InChI=1S/C28H35ClN6OS/c1-18(19-7-6-8-21(29)13-19)32-26(36)35-11-9-34(10-12-35)25-24-22(30-17-31-25)14-23(37-24)20-15-27(2,3)33-28(4,5)16-20/h6-8,13-15,17-18,33H,9-12,16H2,1-5H3,(H,32,36)/t18-/m0/s1 HIRNPSJKSHGRSC-SFHVURJKSA-N 369255 N-[(1S)-1-(3-chlorophenyl)ethyl]-4-[6- (2,2,6,6-tetramethyl-1,3-dihydropyridin-4- yl)thieno[3,2-d]pyrimidin-4-yl]piperazine- 1-carboxamide::US10227357, Compound P-0569 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369255 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369255&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 86718081 402366049 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729526 Fc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)-c1ncnc2cc(sc12)C1=CCN(CC1)C(=O)C1CC1 InChI=1S/C27H23FN4O3S2/c28-20-5-9-22(10-6-20)37(34,35)31-21-7-3-18(4-8-21)25-26-23(29-16-30-25)15-24(36-26)17-11-13-32(14-12-17)27(33)19-1-2-19/h3-11,15-16,19,31H,1-2,12-14H2 MOTKQOBGUPNJOB-UHFFFAOYSA-N 369256 N-[4-[6-[1-(cyclopropanecarbonyl)-3,6- dihydro-2H-pyridin-4-yl]thieno[3,2- d]pyrimidin-4-yl]phenyl]-4-fluoro- benzenesulfonamide::US10227357, Compound P-0570 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369256 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369256&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90001122 402366050 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729527 Fc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)-c1ncnc2cc(sc12)C1=CCN(CC1)C(=O)C1CC1 InChI=1S/C27H23FN4O3S2/c28-20-5-9-22(10-6-20)37(34,35)31-21-7-3-18(4-8-21)25-26-23(29-16-30-25)15-24(36-26)17-11-13-32(14-12-17)27(33)19-1-2-19/h3-11,15-16,19,31H,1-2,12-14H2 MOTKQOBGUPNJOB-UHFFFAOYSA-N 369256 N-[4-[6-[1-(cyclopropanecarbonyl)-3,6- dihydro-2H-pyridin-4-yl]thieno[3,2- d]pyrimidin-4-yl]phenyl]-4-fluoro- benzenesulfonamide::US10227357, Compound P-0570 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369256 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369256&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90001122 402366050 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729528 O=C(C1CC1)N1CCC(=CC1)c1cc2ncnc(-c3ccc(NS(=O)(=O)C4CC4)cc3)c2s1 InChI=1S/C24H24N4O3S2/c29-24(17-1-2-17)28-11-9-15(10-12-28)21-13-20-23(32-21)22(26-14-25-20)16-3-5-18(6-4-16)27-33(30,31)19-7-8-19/h3-6,9,13-14,17,19,27H,1-2,7-8,10-12H2 KMUQDSCCWKNLFU-UHFFFAOYSA-N 369257 N-[4-[6-[1-(cyclopropanecarbonyl)-3,6- dihydro-2H-pyridin-4-yl]thieno[3,2- d]pyrimidin-4- yl]phenyl]cyclopropanesulfonamide::US10227357, Compound P-0571 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369257 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369257&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 86718100 402366051 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729529 O=C(C1CC1)N1CCC(=CC1)c1cc2ncnc(-c3ccc(NS(=O)(=O)C4CC4)cc3)c2s1 InChI=1S/C24H24N4O3S2/c29-24(17-1-2-17)28-11-9-15(10-12-28)21-13-20-23(32-21)22(26-14-25-20)16-3-5-18(6-4-16)27-33(30,31)19-7-8-19/h3-6,9,13-14,17,19,27H,1-2,7-8,10-12H2 KMUQDSCCWKNLFU-UHFFFAOYSA-N 369257 N-[4-[6-[1-(cyclopropanecarbonyl)-3,6- dihydro-2H-pyridin-4-yl]thieno[3,2- d]pyrimidin-4- yl]phenyl]cyclopropanesulfonamide::US10227357, Compound P-0571 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369257 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369257&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 86718100 402366051 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729530 CS(=O)(=O)Nc1ccc(cc1)-c1ncnc2cc(sc12)C1=CCN(CC1)C(=O)C1CC1 InChI=1S/C22H22N4O3S2/c1-31(28,29)25-17-6-4-15(5-7-17)20-21-18(23-13-24-20)12-19(30-21)14-8-10-26(11-9-14)22(27)16-2-3-16/h4-8,12-13,16,25H,2-3,9-11H2,1H3 XIYJVLKEUNTYOT-UHFFFAOYSA-N 369258 N-[4-[6-[1-(cyclopropanecarbonyl)-3,6- dihydro-2H-pyridin-4-yl]thieno[3,2- d]pyrimidin-4- yl]phenyl]methanesulfonamide::US10227357, Compound P-0572 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369258 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369258&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 73389138 402366052 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729531 CS(=O)(=O)Nc1ccc(cc1)-c1ncnc2cc(sc12)C1=CCN(CC1)C(=O)C1CC1 InChI=1S/C22H22N4O3S2/c1-31(28,29)25-17-6-4-15(5-7-17)20-21-18(23-13-24-20)12-19(30-21)14-8-10-26(11-9-14)22(27)16-2-3-16/h4-8,12-13,16,25H,2-3,9-11H2,1H3 XIYJVLKEUNTYOT-UHFFFAOYSA-N 369258 N-[4-[6-[1-(cyclopropanecarbonyl)-3,6- dihydro-2H-pyridin-4-yl]thieno[3,2- d]pyrimidin-4- yl]phenyl]methanesulfonamide::US10227357, Compound P-0572 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369258 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369258&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 73389138 402366052 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729532 C[C@H](NC(=O)N1CCC(=CC1)c1ncnc2cc(sc12)-c1ccc(F)cc1)c1cccc(OC(F)F)c1 InChI=1S/C27H23F3N4O2S/c1-16(19-3-2-4-21(13-19)36-26(29)30)33-27(35)34-11-9-18(10-12-34)24-25-22(31-15-32-24)14-23(37-25)17-5-7-20(28)8-6-17/h2-9,13-16,26H,10-12H2,1H3,(H,33,35)/t16-/m0/s1 CVCKZYDCTFTAEJ-INIZCTEOSA-N 369259 N-[(1S)-1-[3- (difluoromethoxy)phenyl]ethyl]-4-[6-(4- fluorophenyl)thieno[3,2-d]pyrimidin-4-yl]- 3,6-dihydro-2H-pyridine-1-carboxamide::US10227357, Compound P-0573 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369259 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369259&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 73389139 402366053 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729533 C[C@H](NC(=O)N1CCC(=CC1)c1ncnc2cc(sc12)-c1ccc(F)cc1)c1cccc(OC(F)F)c1 InChI=1S/C27H23F3N4O2S/c1-16(19-3-2-4-21(13-19)36-26(29)30)33-27(35)34-11-9-18(10-12-34)24-25-22(31-15-32-24)14-23(37-25)17-5-7-20(28)8-6-17/h2-9,13-16,26H,10-12H2,1H3,(H,33,35)/t16-/m0/s1 CVCKZYDCTFTAEJ-INIZCTEOSA-N 369259 N-[(1S)-1-[3- (difluoromethoxy)phenyl]ethyl]-4-[6-(4- fluorophenyl)thieno[3,2-d]pyrimidin-4-yl]- 3,6-dihydro-2H-pyridine-1-carboxamide::US10227357, Compound P-0573 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369259 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369259&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 73389139 402366053 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729534 COc1cccc(c1)[C@H](C)NC(=O)N1CCN(CC1)c1ncnc2cc(sc12)C1=CC(C)(C)NC(C)(C)C1 InChI=1S/C29H38N6O2S/c1-19(20-8-7-9-22(14-20)37-6)32-27(36)35-12-10-34(11-13-35)26-25-23(30-18-31-26)15-24(38-25)21-16-28(2,3)33-29(4,5)17-21/h7-9,14-16,18-19,33H,10-13,17H2,1-6H3,(H,32,36)/t19-/m0/s1 UYCQNRKFUMWWBD-IBGZPJMESA-N 369260 N-[(1S)-1-(3-methoxyphenyl)ethyl]-4-[6- (2,2,6,6-tetramethyl-1,3-dihydropyridin-4- yl)thieno[3,2-d]pyrimidin-4-yl]piperazine- 1-carboxamide::US10227357, Compound P-0574 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369260 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369260&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 86718080 402366054 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729535 COc1cccc(c1)[C@H](C)NC(=O)N1CCN(CC1)c1ncnc2cc(sc12)C1=CC(C)(C)NC(C)(C)C1 InChI=1S/C29H38N6O2S/c1-19(20-8-7-9-22(14-20)37-6)32-27(36)35-12-10-34(11-13-35)26-25-23(30-18-31-26)15-24(38-25)21-16-28(2,3)33-29(4,5)17-21/h7-9,14-16,18-19,33H,10-13,17H2,1-6H3,(H,32,36)/t19-/m0/s1 UYCQNRKFUMWWBD-IBGZPJMESA-N 369260 N-[(1S)-1-(3-methoxyphenyl)ethyl]-4-[6- (2,2,6,6-tetramethyl-1,3-dihydropyridin-4- yl)thieno[3,2-d]pyrimidin-4-yl]piperazine- 1-carboxamide::US10227357, Compound P-0574 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369260 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369260&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 86718080 402366054 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729536 C[C@H](NC(=O)N1CCN(CC1(C)C)c1ncnc2cc(sc12)-c1ccc(F)cc1)c1ccc(Cl)cc1 InChI=1S/C27H27ClFN5OS/c1-17(18-4-8-20(28)9-5-18)32-26(35)34-13-12-33(15-27(34,2)3)25-24-22(30-16-31-25)14-23(36-24)19-6-10-21(29)11-7-19/h4-11,14,16-17H,12-13,15H2,1-3H3,(H,32,35)/t17-/m0/s1 RNMWRGMXMKHZNZ-KRWDZBQOSA-N 369261 N-[(1S)-1-(4-chlorophenyl)ethyl]-4-[6-(4- fluorophenyl)thieno[3,2-d]pyrimidin-4-yl]- 2,2-dimethyl-piperazine-1-carboxamide::US10227357, Compound P-0575 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369261 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369261&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 73389141 402366055 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729537 C[C@H](NC(=O)N1CCN(CC1(C)C)c1ncnc2cc(sc12)-c1ccc(F)cc1)c1ccc(Cl)cc1 InChI=1S/C27H27ClFN5OS/c1-17(18-4-8-20(28)9-5-18)32-26(35)34-13-12-33(15-27(34,2)3)25-24-22(30-16-31-25)14-23(36-24)19-6-10-21(29)11-7-19/h4-11,14,16-17H,12-13,15H2,1-3H3,(H,32,35)/t17-/m0/s1 RNMWRGMXMKHZNZ-KRWDZBQOSA-N 369261 N-[(1S)-1-(4-chlorophenyl)ethyl]-4-[6-(4- fluorophenyl)thieno[3,2-d]pyrimidin-4-yl]- 2,2-dimethyl-piperazine-1-carboxamide::US10227357, Compound P-0575 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369261 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369261&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 73389141 402366055 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729538 COc1ccc(cc1)[C@H](C)NC(=O)N1CCN(CC1(C)C)c1ncnc2cc(sc12)-c1ccc(F)cc1 InChI=1S/C28H30FN5O2S/c1-18(19-7-11-22(36-4)12-8-19)32-27(35)34-14-13-33(16-28(34,2)3)26-25-23(30-17-31-26)15-24(37-25)20-5-9-21(29)10-6-20/h5-12,15,17-18H,13-14,16H2,1-4H3,(H,32,35)/t18-/m0/s1 UPJHMXAFGPVQCK-SFHVURJKSA-N 369262 4-[6-(4-fluorophenyl)thieno[3,2- d]pyrimidin-4-yl]-N-[(1S)-1-(4- methoxyphenyl)ethyl]-2,2-dimethyl- piperazine-1-carboxamide::US10227357, Compound P-0576 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369262 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369262&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115031 402366056 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729539 COc1ccc(cc1)[C@H](C)NC(=O)N1CCN(CC1(C)C)c1ncnc2cc(sc12)-c1ccc(F)cc1 InChI=1S/C28H30FN5O2S/c1-18(19-7-11-22(36-4)12-8-19)32-27(35)34-14-13-33(16-28(34,2)3)26-25-23(30-17-31-26)15-24(37-25)20-5-9-21(29)10-6-20/h5-12,15,17-18H,13-14,16H2,1-4H3,(H,32,35)/t18-/m0/s1 UPJHMXAFGPVQCK-SFHVURJKSA-N 369262 4-[6-(4-fluorophenyl)thieno[3,2- d]pyrimidin-4-yl]-N-[(1S)-1-(4- methoxyphenyl)ethyl]-2,2-dimethyl- piperazine-1-carboxamide::US10227357, Compound P-0576 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369262 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369262&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115031 402366056 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729540 C[C@H](NC(=O)N1CCN(CC1(C)C)c1ncnc2cc(sc12)-c1ccc(F)cc1)c1cccc(OC(F)F)c1 InChI=1S/C28H28F3N5O2S/c1-17(19-5-4-6-21(13-19)38-26(30)31)34-27(37)36-12-11-35(15-28(36,2)3)25-24-22(32-16-33-25)14-23(39-24)18-7-9-20(29)10-8-18/h4-10,13-14,16-17,26H,11-12,15H2,1-3H3,(H,34,37)/t17-/m0/s1 LIBHISACUSSGMY-KRWDZBQOSA-N 369263 N-[(1S)-1-(3- (difluoromethoxy)phenyl]ethyl]-4-[6-(4- fluorophenyl)thieno[3,2-d]pyrimidin-4-yl]- 2,2-dimethyl-piperazine-1-carboxamide::US10227357, Compound P-0577 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369263 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369263&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 73389220 402366057 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729541 C[C@H](NC(=O)N1CCN(CC1(C)C)c1ncnc2cc(sc12)-c1ccc(F)cc1)c1cccc(OC(F)F)c1 InChI=1S/C28H28F3N5O2S/c1-17(19-5-4-6-21(13-19)38-26(30)31)34-27(37)36-12-11-35(15-28(36,2)3)25-24-22(32-16-33-25)14-23(39-24)18-7-9-20(29)10-8-18/h4-10,13-14,16-17,26H,11-12,15H2,1-3H3,(H,34,37)/t17-/m0/s1 LIBHISACUSSGMY-KRWDZBQOSA-N 369263 N-[(1S)-1-(3- (difluoromethoxy)phenyl]ethyl]-4-[6-(4- fluorophenyl)thieno[3,2-d]pyrimidin-4-yl]- 2,2-dimethyl-piperazine-1-carboxamide::US10227357, Compound P-0577 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369263 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369263&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 73389220 402366057 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729542 C[C@H](NC(=O)N1CCN(CC1(C)C)c1ncnc2cc(sc12)-c1ccc(F)cc1)c1cccc(F)c1 InChI=1S/C27H27F2N5OS/c1-17(19-5-4-6-21(29)13-19)32-26(35)34-12-11-33(15-27(34,2)3)25-24-22(30-16-31-25)14-23(36-24)18-7-9-20(28)10-8-18/h4-10,13-14,16-17H,11-12,15H2,1-3H3,(H,32,35)/t17-/m0/s1 HHJMMRRXYBXNIY-KRWDZBQOSA-N 369264 N-[(1S)-1-(3-fluorophenyl)ethyl]-4-[6-(4- fluorophenyl)thieno[3,2-d]pyrimidin-4-yl]- 2,2-dimethyl-piperazine-1-carboxamide::US10227357, Compound P-0578 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369264 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369264&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 73389221 402366058 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729543 C[C@H](NC(=O)N1CCC(=CC1)c1ncnc2cc(sc12)-c1ccc(F)cc1)c1cccc(Cl)c1 InChI=1S/C26H22ClFN4OS/c1-16(19-3-2-4-20(27)13-19)31-26(33)32-11-9-18(10-12-32)24-25-22(29-15-30-24)14-23(34-25)17-5-7-21(28)8-6-17/h2-9,13-16H,10-12H2,1H3,(H,31,33)/t16-/m0/s1 QOBIVNUFCRVLDY-INIZCTEOSA-N 369265 N-[(1S)-1-(3-chlorophenyl)ethyl]-4-[6-(4- fluorophenyl)thieno[3,2-d]pyrimidin-4-yl]- 3,6-dihydro-2H-pyridine-1-carboxamide::US10227357, Compound P-0579 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369265 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369265&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 73389222 402366059 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729544 C[C@H](NC(=O)N1CCC(=CC1)c1ncnc2cc(sc12)-c1ccc(F)cc1)c1cccc(Cl)c1 InChI=1S/C26H22ClFN4OS/c1-16(19-3-2-4-20(27)13-19)31-26(33)32-11-9-18(10-12-32)24-25-22(29-15-30-24)14-23(34-25)17-5-7-21(28)8-6-17/h2-9,13-16H,10-12H2,1H3,(H,31,33)/t16-/m0/s1 QOBIVNUFCRVLDY-INIZCTEOSA-N 369265 N-[(1S)-1-(3-chlorophenyl)ethyl]-4-[6-(4- fluorophenyl)thieno[3,2-d]pyrimidin-4-yl]- 3,6-dihydro-2H-pyridine-1-carboxamide::US10227357, Compound P-0579 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369265 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369265&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 73389222 402366059 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729545 C[C@H](NC(=O)N1CCN(CC1(C)C)c1ncnc2cc(sc12)-c1ccc(F)cc1)c1cccc(Cl)c1 InChI=1S/C27H27ClFN5OS/c1-17(19-5-4-6-20(28)13-19)32-26(35)34-12-11-33(15-27(34,2)3)25-24-22(30-16-31-25)14-23(36-24)18-7-9-21(29)10-8-18/h4-10,13-14,16-17H,11-12,15H2,1-3H3,(H,32,35)/t17-/m0/s1 PXPOLOUTTVTSFI-KRWDZBQOSA-N 369266 N-[(1S)-1-(3-chlorophenyl)ethyl]-4-[6-(4- fluorophenyl)thieno[3,2-d]pyrimidin-4-yl]- 2,2-dimethyl-piperazine-1-carboxamide::US10227357, Compound P-0580 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369266 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369266&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 73389050 402366060 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729546 C[C@H](NC(=O)N1CCN(CC1(C)C)c1ncnc2cc(sc12)-c1ccc(F)cc1)c1cccc(Cl)c1 InChI=1S/C27H27ClFN5OS/c1-17(19-5-4-6-20(28)13-19)32-26(35)34-12-11-33(15-27(34,2)3)25-24-22(30-16-31-25)14-23(36-24)18-7-9-21(29)10-8-18/h4-10,13-14,16-17H,11-12,15H2,1-3H3,(H,32,35)/t17-/m0/s1 PXPOLOUTTVTSFI-KRWDZBQOSA-N 369266 N-[(1S)-1-(3-chlorophenyl)ethyl]-4-[6-(4- fluorophenyl)thieno[3,2-d]pyrimidin-4-yl]- 2,2-dimethyl-piperazine-1-carboxamide::US10227357, Compound P-0580 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369266 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369266&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 73389050 402366060 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729547 COc1cccc(c1)[C@H](C)NC(=O)N1CCC(=CC1)c1ncnc2cc(sc12)-c1ccc(F)cc1 InChI=1S/C27H25FN4O2S/c1-17(20-4-3-5-22(14-20)34-2)31-27(33)32-12-10-19(11-13-32)25-26-23(29-16-30-25)15-24(35-26)18-6-8-21(28)9-7-18/h3-10,14-17H,11-13H2,1-2H3,(H,31,33)/t17-/m0/s1 PXTPJWQAJBVRMM-KRWDZBQOSA-N 369267 4-[6-(4-fluorophenyl)thieno[3,2- d]pyrimidin-4-yl]-N-[(1S)-1-(3- methoxyphenyl)ethyl]-3,6-dihydro-2H- pyridine-1-carboxamide::US10227357, Compound P-0581 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369267 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369267&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 73389052 402366061 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729548 COc1cccc(c1)[C@H](C)NC(=O)N1CCC(=CC1)c1ncnc2cc(sc12)-c1ccc(F)cc1 InChI=1S/C27H25FN4O2S/c1-17(20-4-3-5-22(14-20)34-2)31-27(33)32-12-10-19(11-13-32)25-26-23(29-16-30-25)15-24(35-26)18-6-8-21(28)9-7-18/h3-10,14-17H,11-13H2,1-2H3,(H,31,33)/t17-/m0/s1 PXTPJWQAJBVRMM-KRWDZBQOSA-N 369267 4-[6-(4-fluorophenyl)thieno[3,2- d]pyrimidin-4-yl]-N-[(1S)-1-(3- methoxyphenyl)ethyl]-3,6-dihydro-2H- pyridine-1-carboxamide::US10227357, Compound P-0581 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369267 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369267&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 73389052 402366061 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729549 COc1cccc(c1)[C@H](C)NC(=O)N1CCC(=CC1)c1ncnc2cc(sc12)-c1cn(C)nc1C InChI=1S/C26H28N6O2S/c1-16(19-6-5-7-20(12-19)34-4)29-26(33)32-10-8-18(9-11-32)24-25-22(27-15-28-24)13-23(35-25)21-14-31(3)30-17(21)2/h5-8,12-16H,9-11H2,1-4H3,(H,29,33)/t16-/m0/s1 IYRXELIBYKOYPJ-INIZCTEOSA-N 369268 4-[6-(1,3-dimethylpyrazol-4-yl)thieno[3,2- d]pyrimidin-4-yl]-N-[(1S)-1-(3- methoxyphenyl)ethyl]-3,6-dihydro-2H- pyridine-1-carboxamide::US10227357, Compound P-0582 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369268 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369268&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 86718062 402366062 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729550 COc1cccc(c1)[C@H](C)NC(=O)N1CCC(=CC1)c1ncnc2cc(sc12)-c1cn(C)nc1C InChI=1S/C26H28N6O2S/c1-16(19-6-5-7-20(12-19)34-4)29-26(33)32-10-8-18(9-11-32)24-25-22(27-15-28-24)13-23(35-25)21-14-31(3)30-17(21)2/h5-8,12-16H,9-11H2,1-4H3,(H,29,33)/t16-/m0/s1 IYRXELIBYKOYPJ-INIZCTEOSA-N 369268 4-[6-(1,3-dimethylpyrazol-4-yl)thieno[3,2- d]pyrimidin-4-yl]-N-[(1S)-1-(3- methoxyphenyl)ethyl]-3,6-dihydro-2H- pyridine-1-carboxamide::US10227357, Compound P-0582 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369268 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369268&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 86718062 402366062 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729551 Cc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)-c1ncnc2cc(sc12)C1=CCN(CC1)C(=O)C1CC1 InChI=1S/C28H26N4O3S2/c1-18-2-10-23(11-3-18)37(34,35)31-22-8-6-20(7-9-22)26-27-24(29-17-30-26)16-25(36-27)19-12-14-32(15-13-19)28(33)21-4-5-21/h2-3,6-12,16-17,21,31H,4-5,13-15H2,1H3 YDBWFLCEPUPKSZ-UHFFFAOYSA-N 369269 N-[4-[6-[1-(cyclopropanecarbonyl)-3,6- dihydro-2H-pyridin-4-yl]thieno[3,2- d]pyrimidin-4-yl]phenyl]-4-methyl- benzenesulfonamide::US10227357, Compound P-0583 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369269 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369269&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115068 402366063 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729552 Cc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)-c1ncnc2cc(sc12)C1=CCN(CC1)C(=O)C1CC1 InChI=1S/C28H26N4O3S2/c1-18-2-10-23(11-3-18)37(34,35)31-22-8-6-20(7-9-22)26-27-24(29-17-30-26)16-25(36-27)19-12-14-32(15-13-19)28(33)21-4-5-21/h2-3,6-12,16-17,21,31H,4-5,13-15H2,1H3 YDBWFLCEPUPKSZ-UHFFFAOYSA-N 369269 N-[4-[6-[1-(cyclopropanecarbonyl)-3,6- dihydro-2H-pyridin-4-yl]thieno[3,2- d]pyrimidin-4-yl]phenyl]-4-methyl- benzenesulfonamide::US10227357, Compound P-0583 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369269 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369269&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115068 402366063 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729553 C[C@H](NC(=O)N1CCN(C[C@H]1C)c1ncnc2cc(sc12)-c1cn(C)nc1C)c1cccc(F)c1 InChI=1S/C25H28FN7OS/c1-15-12-32(8-9-33(15)25(34)29-16(2)18-6-5-7-19(26)10-18)24-23-21(27-14-28-24)11-22(35-23)20-13-31(4)30-17(20)3/h5-7,10-11,13-16H,8-9,12H2,1-4H3,(H,29,34)/t15-,16+/m1/s1 OJKDVGRNMLAPSE-CVEARBPZSA-N 369270 (2R)-4-[6-(1,3-dimethylpyrazol-4- yl)thieno[3,2-d]pyrimidin-4-yl]-N-[(1S)-1- (3-fluorophenyl)ethyl]-2-methyl- piperazine-1-carboxamide::US10227357, Compound P-0584 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369270 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369270&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114704 402366064 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729554 C[C@H](NC(=O)N1CCN(C[C@H]1C)c1ncnc2cc(sc12)-c1cn(C)nc1C)c1cccc(F)c1 InChI=1S/C25H28FN7OS/c1-15-12-32(8-9-33(15)25(34)29-16(2)18-6-5-7-19(26)10-18)24-23-21(27-14-28-24)11-22(35-23)20-13-31(4)30-17(20)3/h5-7,10-11,13-16H,8-9,12H2,1-4H3,(H,29,34)/t15-,16+/m1/s1 OJKDVGRNMLAPSE-CVEARBPZSA-N 369270 (2R)-4-[6-(1,3-dimethylpyrazol-4- yl)thieno[3,2-d]pyrimidin-4-yl]-N-[(1S)-1- (3-fluorophenyl)ethyl]-2-methyl- piperazine-1-carboxamide::US10227357, Compound P-0584 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369270 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369270&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114704 402366064 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729555 C[C@H](NC(=O)N1CCN(C[C@H]1C)c1ncnc2cc(sc12)-c1ccc(F)cc1)c1cccc(F)c1 InChI=1S/C26H25F2N5OS/c1-16-14-32(10-11-33(16)26(34)31-17(2)19-4-3-5-21(28)12-19)25-24-22(29-15-30-25)13-23(35-24)18-6-8-20(27)9-7-18/h3-9,12-13,15-17H,10-11,14H2,1-2H3,(H,31,34)/t16-,17+/m1/s1 HSYALMIXPQNBPU-SJORKVTESA-N 369271 (2R)-N-[(1S)-1-(3-fluorophenyl)ethyl]-4-[6- (4-fluorophenyl)thieno[3,2-d]pyrimidin-4- yl]-2-methyl-piperazine-1-carboxamide::US10227357, Compound P-0585 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369271 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369271&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 86718068 402366065 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729556 C[C@H](NC(=O)N1CCN(C[C@H]1C)c1ncnc2cc(sc12)-c1ccc(F)cc1)c1cccc(F)c1 InChI=1S/C26H25F2N5OS/c1-16-14-32(10-11-33(16)26(34)31-17(2)19-4-3-5-21(28)12-19)25-24-22(29-15-30-25)13-23(35-24)18-6-8-20(27)9-7-18/h3-9,12-13,15-17H,10-11,14H2,1-2H3,(H,31,34)/t16-,17+/m1/s1 HSYALMIXPQNBPU-SJORKVTESA-N 369271 (2R)-N-[(1S)-1-(3-fluorophenyl)ethyl]-4-[6- (4-fluorophenyl)thieno[3,2-d]pyrimidin-4- yl]-2-methyl-piperazine-1-carboxamide::US10227357, Compound P-0585 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369271 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369271&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 86718068 402366065 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729557 C[C@H](NC(=O)N1CCN(C[C@H]1C)c1ncnc2cc(sc12)-c1ccc(F)cc1)c1cccc(OC(F)F)c1 InChI=1S/C27H26F3N5O2S/c1-16-14-34(25-24-22(31-15-32-25)13-23(38-24)18-6-8-20(28)9-7-18)10-11-35(16)27(36)33-17(2)19-4-3-5-21(12-19)37-26(29)30/h3-9,12-13,15-17,26H,10-11,14H2,1-2H3,(H,33,36)/t16-,17+/m1/s1 MOZCUJDDVXIATN-SJORKVTESA-N 369272 (2R)-N-[(1S)-1-[3- (difluoromethoxy)phenyl]ethyl]-4-[6-(4- fluorophenyl)thieno[3,2-d]pyrimidin-4-yl]- 2-methyl-piperazine-1-carboxamide::US10227357, Compound P-0586 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369272 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369272&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114734 402366066 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729558 C[C@H](NC(=O)N1CCN(C[C@H]1C)c1ncnc2cc(sc12)-c1ccc(F)cc1)c1cccc(OC(F)F)c1 InChI=1S/C27H26F3N5O2S/c1-16-14-34(25-24-22(31-15-32-25)13-23(38-24)18-6-8-20(28)9-7-18)10-11-35(16)27(36)33-17(2)19-4-3-5-21(12-19)37-26(29)30/h3-9,12-13,15-17,26H,10-11,14H2,1-2H3,(H,33,36)/t16-,17+/m1/s1 MOZCUJDDVXIATN-SJORKVTESA-N 369272 (2R)-N-[(1S)-1-[3- (difluoromethoxy)phenyl]ethyl]-4-[6-(4- fluorophenyl)thieno[3,2-d]pyrimidin-4-yl]- 2-methyl-piperazine-1-carboxamide::US10227357, Compound P-0586 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369272 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369272&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114734 402366066 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729559 C[C@H](NC(=O)N1CCN(C[C@H]1C)c1ncnc2cc(sc12)-c1cn(C)nc1C)c1cccc(OC(F)F)c1 InChI=1S/C26H29F2N7O2S/c1-15-12-34(24-23-21(29-14-30-24)11-22(38-23)20-13-33(4)32-17(20)3)8-9-35(15)26(36)31-16(2)18-6-5-7-19(10-18)37-25(27)28/h5-7,10-11,13-16,25H,8-9,12H2,1-4H3,(H,31,36)/t15-,16+/m1/s1 YBXXQJMZAYPNCH-CVEARBPZSA-N 369273 (2R)-N-[(1S)-1-[3- (difluoromethoxy)phenyl]ethyl]-4-[6-(1,3- dimethylpyrazol-4-yl)thieno[3,2- d]pyrimidin-4-yl]-2-methyl-piperazine-1- carboxamide::US10227357, Compound P-0587 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369273 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369273&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115318 402366067 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729560 C[C@H](NC(=O)N1CCN(C[C@H]1C)c1ncnc2cc(sc12)-c1cn(C)nc1C)c1cccc(OC(F)F)c1 InChI=1S/C26H29F2N7O2S/c1-15-12-34(24-23-21(29-14-30-24)11-22(38-23)20-13-33(4)32-17(20)3)8-9-35(15)26(36)31-16(2)18-6-5-7-19(10-18)37-25(27)28/h5-7,10-11,13-16,25H,8-9,12H2,1-4H3,(H,31,36)/t15-,16+/m1/s1 YBXXQJMZAYPNCH-CVEARBPZSA-N 369273 (2R)-N-[(1S)-1-[3- (difluoromethoxy)phenyl]ethyl]-4-[6-(1,3- dimethylpyrazol-4-yl)thieno[3,2- d]pyrimidin-4-yl]-2-methyl-piperazine-1- carboxamide::US10227357, Compound P-0587 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369273 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369273&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115318 402366067 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729561 Fc1ccc(CNC(=O)N2CCN(CC2)c2ncnc3cc(sc23)C2CCN(CC2)C(=O)C2CC2)cc1 InChI=1S/C27H31FN6O2S/c28-21-5-1-18(2-6-21)16-29-27(36)34-13-11-32(12-14-34)25-24-22(30-17-31-25)15-23(37-24)19-7-9-33(10-8-19)26(35)20-3-4-20/h1-2,5-6,15,17,19-20H,3-4,7-14,16H2,(H,29,36) AFUSQLMGUGDTDK-UHFFFAOYSA-N 369274 4-[6-[1-(cyclopropanecarbonyl)-4- piperidyl]thieno[3,2-d]pyrimidin-4-yl]-N- [(4-fluorophenyl)methyl]piperazine-1- carboxamide::US10227357, Compound P-0588 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369274 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369274&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 73388971 402366068 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729562 Fc1ccc(CNC(=O)N2CCN(CC2)c2ncnc3cc(sc23)C2CCN(CC2)C(=O)C2CC2)cc1 InChI=1S/C27H31FN6O2S/c28-21-5-1-18(2-6-21)16-29-27(36)34-13-11-32(12-14-34)25-24-22(30-17-31-25)15-23(37-24)19-7-9-33(10-8-19)26(35)20-3-4-20/h1-2,5-6,15,17,19-20H,3-4,7-14,16H2,(H,29,36) AFUSQLMGUGDTDK-UHFFFAOYSA-N 369274 4-[6-[1-(cyclopropanecarbonyl)-4- piperidyl]thieno[3,2-d]pyrimidin-4-yl]-N- [(4-fluorophenyl)methyl]piperazine-1- carboxamide::US10227357, Compound P-0588 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369274 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369274&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 73388971 402366068 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729563 C[C@H](NC(=O)N1CCN(CC1)c1ncnc2cc(sc12)N1CCOCC1)c1ccc(F)cc1 InChI=1S/C23H27FN6O2S/c1-16(17-2-4-18(24)5-3-17)27-23(31)30-8-6-29(7-9-30)22-21-19(25-15-26-22)14-20(33-21)28-10-12-32-13-11-28/h2-5,14-16H,6-13H2,1H3,(H,27,31)/t16-/m0/s1 IHWZBZOVUMJSAS-INIZCTEOSA-N 369275 N-[(1S)-1-(4-fluorophenyl)ethyl]-4-(6- morpholinothieno[3,2-d]pyrimidin-4- yl)piperazine-1-carboxamide::US10227357, Compound P-0589 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369275 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369275&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114582 402366069 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729564 C[C@H](NC(=O)N1CCN(CC1)c1ncnc2cc(sc12)N1CCOCC1)c1ccc(F)cc1 InChI=1S/C23H27FN6O2S/c1-16(17-2-4-18(24)5-3-17)27-23(31)30-8-6-29(7-9-30)22-21-19(25-15-26-22)14-20(33-21)28-10-12-32-13-11-28/h2-5,14-16H,6-13H2,1H3,(H,27,31)/t16-/m0/s1 IHWZBZOVUMJSAS-INIZCTEOSA-N 369275 N-[(1S)-1-(4-fluorophenyl)ethyl]-4-(6- morpholinothieno[3,2-d]pyrimidin-4- yl)piperazine-1-carboxamide::US10227357, Compound P-0589 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369275 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369275&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114582 402366069 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729565 Cc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)-c1ncnc2cc(sc12)C1=CCN(CC1)C(=O)N1CCOCC1 InChI=1S/C29H29N5O4S2/c1-20-2-8-24(9-3-20)40(36,37)32-23-6-4-22(5-7-23)27-28-25(30-19-31-27)18-26(39-28)21-10-12-33(13-11-21)29(35)34-14-16-38-17-15-34/h2-10,18-19,32H,11-17H2,1H3 HBGHSLWVMYVYLG-UHFFFAOYSA-N 369276 4-methyl-N-[4-[6-[1-(morpholine-4- carbonyl)-3,6-dihydro-2H-pyridin-4- yl]thieno[3,2-d]pyrimidin-4- yl]phenyl]benzenesulfonamide::US10227357, Compound P-0590 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369276 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369276&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90001038 402366070 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729566 Cc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)-c1ncnc2cc(sc12)C1=CCN(CC1)C(=O)N1CCOCC1 InChI=1S/C29H29N5O4S2/c1-20-2-8-24(9-3-20)40(36,37)32-23-6-4-22(5-7-23)27-28-25(30-19-31-27)18-26(39-28)21-10-12-33(13-11-21)29(35)34-14-16-38-17-15-34/h2-10,18-19,32H,11-17H2,1H3 HBGHSLWVMYVYLG-UHFFFAOYSA-N 369276 4-methyl-N-[4-[6-[1-(morpholine-4- carbonyl)-3,6-dihydro-2H-pyridin-4- yl]thieno[3,2-d]pyrimidin-4- yl]phenyl]benzenesulfonamide::US10227357, Compound P-0590 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369276 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369276&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90001038 402366070 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729567 C[C@H](NC(=O)N1CCN(C[C@H]1C)c1ncnc2cc(sc12)-c1cn(C)nc1C)c1cccc(Cl)c1 InChI=1S/C25H28ClN7OS/c1-15-12-32(8-9-33(15)25(34)29-16(2)18-6-5-7-19(26)10-18)24-23-21(27-14-28-24)11-22(35-23)20-13-31(4)30-17(20)3/h5-7,10-11,13-16H,8-9,12H2,1-4H3,(H,29,34)/t15-,16+/m1/s1 NVOCRGSSYWAHKY-CVEARBPZSA-N 369277 (2R)-N-[(1S)-1-(3-chlorophenyl)ethyl]-4- [6-(1,3-dimethylpyrazol-4-yl)thieno[3,2- d]pyrimidin-4-yl]-2-methyl-piperazine-1- carboxamide::US10227357, Compound P-0591 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369277 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369277&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 73388973 402366071 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729568 C[C@H](NC(=O)N1CCN(C[C@H]1C)c1ncnc2cc(sc12)-c1cn(C)nc1C)c1cccc(Cl)c1 InChI=1S/C25H28ClN7OS/c1-15-12-32(8-9-33(15)25(34)29-16(2)18-6-5-7-19(26)10-18)24-23-21(27-14-28-24)11-22(35-23)20-13-31(4)30-17(20)3/h5-7,10-11,13-16H,8-9,12H2,1-4H3,(H,29,34)/t15-,16+/m1/s1 NVOCRGSSYWAHKY-CVEARBPZSA-N 369277 (2R)-N-[(1S)-1-(3-chlorophenyl)ethyl]-4- [6-(1,3-dimethylpyrazol-4-yl)thieno[3,2- d]pyrimidin-4-yl]-2-methyl-piperazine-1- carboxamide::US10227357, Compound P-0591 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369277 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369277&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 73388973 402366071 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729569 Cc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)-c1ncnc2cc(sc12)C1CCNCC1 InChI=1S/C24H24N4O2S2/c1-16-2-8-20(9-3-16)32(29,30)28-19-6-4-18(5-7-19)23-24-21(26-15-27-23)14-22(31-24)17-10-12-25-13-11-17/h2-9,14-15,17,25,28H,10-13H2,1H3 ISOPHKJIVMLXNI-UHFFFAOYSA-N 369278 4-methyl-N-[4-[6-(4-piperidyl)thieno[3,2- d]pyrimidin-4- yl]phenyl]benzenesulfonamide::US10227357, Compound P-0592 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369278 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369278&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 89994024 402366072 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729570 Cc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)-c1ncnc2cc(sc12)C1CCNCC1 InChI=1S/C24H24N4O2S2/c1-16-2-8-20(9-3-16)32(29,30)28-19-6-4-18(5-7-19)23-24-21(26-15-27-23)14-22(31-24)17-10-12-25-13-11-17/h2-9,14-15,17,25,28H,10-13H2,1H3 ISOPHKJIVMLXNI-UHFFFAOYSA-N 369278 4-methyl-N-[4-[6-(4-piperidyl)thieno[3,2- d]pyrimidin-4- yl]phenyl]benzenesulfonamide::US10227357, Compound P-0592 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369278 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369278&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 89994024 402366072 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729571 C[C@H](NC(=O)N1CCN(CC1(C)C)c1ncnc2cc(sc12)-c1ccc(F)cc1)c1ccc(F)cc1 InChI=1S/C27H27F2N5OS/c1-17(18-4-8-20(28)9-5-18)32-26(35)34-13-12-33(15-27(34,2)3)25-24-22(30-16-31-25)14-23(36-24)19-6-10-21(29)11-7-19/h4-11,14,16-17H,12-13,15H2,1-3H3,(H,32,35)/t17-/m0/s1 ACBIBYDBYIBUCB-KRWDZBQOSA-N 369279 N-[(1S)-1-(4-fluorophenyl)ethyl]-4-[6-(4- fluorophenyl)thieno[3,2-d]pyrimidin-4-yl]- 2,2-dimethyl-piperazine-1-carboxamide::US10227357, Compound P-0593 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369279 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369279&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114440 402366073 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729572 C[C@H](NC(=O)N1CCN(CC1(C)C)c1ncnc2cc(sc12)-c1ccc(F)cc1)c1ccc(F)cc1 InChI=1S/C27H27F2N5OS/c1-17(18-4-8-20(28)9-5-18)32-26(35)34-13-12-33(15-27(34,2)3)25-24-22(30-16-31-25)14-23(36-24)19-6-10-21(29)11-7-19/h4-11,14,16-17H,12-13,15H2,1-3H3,(H,32,35)/t17-/m0/s1 ACBIBYDBYIBUCB-KRWDZBQOSA-N 369279 N-[(1S)-1-(4-fluorophenyl)ethyl]-4-[6-(4- fluorophenyl)thieno[3,2-d]pyrimidin-4-yl]- 2,2-dimethyl-piperazine-1-carboxamide::US10227357, Compound P-0593 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369279 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369279&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114440 402366073 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729573 COc1cccc(c1)[C@H](C)NC(=O)N1CCN(CC1(C)C)c1ncnc2cc(sc12)-c1ccc(F)cc1 InChI=1S/C28H30FN5O2S/c1-18(20-6-5-7-22(14-20)36-4)32-27(35)34-13-12-33(16-28(34,2)3)26-25-23(30-17-31-26)15-24(37-25)19-8-10-21(29)11-9-19/h5-11,14-15,17-18H,12-13,16H2,1-4H3,(H,32,35)/t18-/m0/s1 FKLWMKIZISTLLY-SFHVURJKSA-N 369280 4-[6-(4-fluorophenyl)thieno[3,2- d]pyrimidin-4-yl]-N-[(1S)-1-(3- methoxyphenyl)ethyl]-2,2-dimethyl- piperazine-1-carboxamide::US10227357, Compound P-0594 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369280 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369280&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 73388975 402366074 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729574 COc1cccc(c1)[C@H](C)NC(=O)N1CCN(CC1(C)C)c1ncnc2cc(sc12)-c1ccc(F)cc1 InChI=1S/C28H30FN5O2S/c1-18(20-6-5-7-22(14-20)36-4)32-27(35)34-13-12-33(16-28(34,2)3)26-25-23(30-17-31-26)15-24(37-25)19-8-10-21(29)11-9-19/h5-11,14-15,17-18H,12-13,16H2,1-4H3,(H,32,35)/t18-/m0/s1 FKLWMKIZISTLLY-SFHVURJKSA-N 369280 4-[6-(4-fluorophenyl)thieno[3,2- d]pyrimidin-4-yl]-N-[(1S)-1-(3- methoxyphenyl)ethyl]-2,2-dimethyl- piperazine-1-carboxamide::US10227357, Compound P-0594 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369280 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369280&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 73388975 402366074 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729575 CC1(C)CN(CCN1)c1ncnc2cc(sc12)-c1ccc(F)cc1 InChI=1S/C18H19FN4S/c1-18(2)10-23(8-7-22-18)17-16-14(20-11-21-17)9-15(24-16)12-3-5-13(19)6-4-12/h3-6,9,11,22H,7-8,10H2,1-2H3 AQAIMWBRINWGLR-UHFFFAOYSA-N 369281 4-(3,3-dimethylpiperazin-1-yl)-6-(4- fluorophenyl)thieno[3,2-d]pyrimidine::US10227357, Compound P-0595 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369281 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369281&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 73388974 402366075 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729576 CC1(C)CN(CCN1)c1ncnc2cc(sc12)-c1ccc(F)cc1 InChI=1S/C18H19FN4S/c1-18(2)10-23(8-7-22-18)17-16-14(20-11-21-17)9-15(24-16)12-3-5-13(19)6-4-12/h3-6,9,11,22H,7-8,10H2,1-2H3 AQAIMWBRINWGLR-UHFFFAOYSA-N 369281 4-(3,3-dimethylpiperazin-1-yl)-6-(4- fluorophenyl)thieno[3,2-d]pyrimidine::US10227357, Compound P-0595 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369281 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369281&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 73388974 402366075 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729577 Fc1ccc(CNC(=O)N2CCN(CC2)c2ncnc3cc(sc23)C2CCNCC2)cc1 InChI=1S/C23H27FN6OS/c24-18-3-1-16(2-4-18)14-26-23(31)30-11-9-29(10-12-30)22-21-19(27-15-28-22)13-20(32-21)17-5-7-25-8-6-17/h1-4,13,15,17,25H,5-12,14H2,(H,26,31) GOJUUJTUYGWRPG-UHFFFAOYSA-N 369282 N-[(4-fluorophenyl)methyl]-4-[6-(4- piperidyl)thieno[3,2-d]pyrimidin-4- yl]piperazine-1-carboxamide::US10227357, Compound P-0596 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369282 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369282&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 73388809 402366076 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729578 Fc1ccc(CNC(=O)N2CCN(CC2)c2ncnc3cc(sc23)C2CCNCC2)cc1 InChI=1S/C23H27FN6OS/c24-18-3-1-16(2-4-18)14-26-23(31)30-11-9-29(10-12-30)22-21-19(27-15-28-22)13-20(32-21)17-5-7-25-8-6-17/h1-4,13,15,17,25H,5-12,14H2,(H,26,31) GOJUUJTUYGWRPG-UHFFFAOYSA-N 369282 N-[(4-fluorophenyl)methyl]-4-[6-(4- piperidyl)thieno[3,2-d]pyrimidin-4- yl]piperazine-1-carboxamide::US10227357, Compound P-0596 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369282 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369282&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 73388809 402366076 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729579 C[C@H](NC(=O)N1CCN(CC1)c1ncnc2cc(Br)sc12)c1ccc(F)cc1 InChI=1S/C19H19BrFN5OS/c1-12(13-2-4-14(21)5-3-13)24-19(27)26-8-6-25(7-9-26)18-17-15(22-11-23-18)10-16(20)28-17/h2-5,10-12H,6-9H2,1H3,(H,24,27)/t12-/m0/s1 IPUFXCNGQVYMSQ-LBPRGKRZSA-N 369283 4-(6-bromothieno[3,2-d]pyrimidin-4-yl)-N- [(1S)-1-(4-fluorophenyl)ethyl]piperazine- 1-carboxamide::US10227357, Compound P-0597 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369283 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369283&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 73388810 402366077 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729580 COc1cccc(c1)[C@H](C)NC(=O)N1CCN(C[C@H]1C)c1ncnc2cc(sc12)-c1cn(C)nc1C InChI=1S/C26H31N7O2S/c1-16-13-32(9-10-33(16)26(34)29-17(2)19-7-6-8-20(11-19)35-5)25-24-22(27-15-28-25)12-23(36-24)21-14-31(4)30-18(21)3/h6-8,11-12,14-17H,9-10,13H2,1-5H3,(H,29,34)/t16-,17+/m1/s1 AKZDLPYXTXCHDN-SJORKVTESA-N 369284 (2R)-4-[6-(1,3-dimethylpyrazol-4- yl)thieno[3,2-d]pyrimidin-4-yl]-N-[(1S)-1- (3-methoxyphenyl)ethyl]-2-methyl- piperazine-1-carboxamide::US10227357, Compound P-0598 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369284 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369284&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 73388811 402366078 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729581 COc1cccc(c1)[C@H](C)NC(=O)N1CCN(C[C@H]1C)c1ncnc2cc(sc12)-c1cn(C)nc1C InChI=1S/C26H31N7O2S/c1-16-13-32(9-10-33(16)26(34)29-17(2)19-7-6-8-20(11-19)35-5)25-24-22(27-15-28-25)12-23(36-24)21-14-31(4)30-18(21)3/h6-8,11-12,14-17H,9-10,13H2,1-5H3,(H,29,34)/t16-,17+/m1/s1 AKZDLPYXTXCHDN-SJORKVTESA-N 369284 (2R)-4-[6-(1,3-dimethylpyrazol-4- yl)thieno[3,2-d]pyrimidin-4-yl]-N-[(1S)-1- (3-methoxyphenyl)ethyl]-2-methyl- piperazine-1-carboxamide::US10227357, Compound P-0598 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369284 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369284&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 73388811 402366078 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729582 C[C@H](NC(=O)N1CCN(C[C@H]1C)c1ncnc2cc(sc12)-c1cn(C)nc1C)c1ccc(F)cc1 InChI=1S/C25H28FN7OS/c1-15-12-32(9-10-33(15)25(34)29-16(2)18-5-7-19(26)8-6-18)24-23-21(27-14-28-24)11-22(35-23)20-13-31(4)30-17(20)3/h5-8,11,13-16H,9-10,12H2,1-4H3,(H,29,34)/t15-,16+/m1/s1 IELRNEVNMCGBFV-CVEARBPZSA-N 369285 (2R)-4-[6-(1,3-dimethylpyrazol-4- yl)thieno[3,2-d]pyrimidin-4-yl]-N-[(1S)-1- (4-fluorophenyl)ethyl]-2-methyl- piperazine-1-carboxamide::US10227357, Compound P-0599 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369285 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369285&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 73388892 402366079 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729583 C[C@H](NC(=O)N1CCN(C[C@H]1C)c1ncnc2cc(sc12)-c1cn(C)nc1C)c1ccc(F)cc1 InChI=1S/C25H28FN7OS/c1-15-12-32(9-10-33(15)25(34)29-16(2)18-5-7-19(26)8-6-18)24-23-21(27-14-28-24)11-22(35-23)20-13-31(4)30-17(20)3/h5-8,11,13-16H,9-10,12H2,1-4H3,(H,29,34)/t15-,16+/m1/s1 IELRNEVNMCGBFV-CVEARBPZSA-N 369285 (2R)-4-[6-(1,3-dimethylpyrazol-4- yl)thieno[3,2-d]pyrimidin-4-yl]-N-[(1S)-1- (4-fluorophenyl)ethyl]-2-methyl- piperazine-1-carboxamide::US10227357, Compound P-0599 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369285 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369285&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 73388892 402366079 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729584 COc1cccc(c1)[C@H](C)NC(=O)N1CCN(C[C@H]1C)c1ncnc2cc(sc12)-c1ccc(F)cc1 InChI=1S/C27H28FN5O2S/c1-17-15-32(11-12-33(17)27(34)31-18(2)20-5-4-6-22(13-20)35-3)26-25-23(29-16-30-26)14-24(36-25)19-7-9-21(28)10-8-19/h4-10,13-14,16-18H,11-12,15H2,1-3H3,(H,31,34)/t17-,18+/m1/s1 IUCXYMVKFYXONK-MSOLQXFVSA-N 369286 (2R)-4-[6-(4-fluorophenyl)thieno[3,2- d]pyrimidin-4-yl]-N-[(1S)-1-(3- methoxyphenyl)ethyl]-2-methyl- piperazine-1-carboxamide::US10227357, Compound P-0600 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369286 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369286&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 73388893 402366080 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729585 COc1cccc(c1)[C@H](C)NC(=O)N1CCN(C[C@H]1C)c1ncnc2cc(sc12)-c1ccc(F)cc1 InChI=1S/C27H28FN5O2S/c1-17-15-32(11-12-33(17)27(34)31-18(2)20-5-4-6-22(13-20)35-3)26-25-23(29-16-30-26)14-24(36-25)19-7-9-21(28)10-8-19/h4-10,13-14,16-18H,11-12,15H2,1-3H3,(H,31,34)/t17-,18+/m1/s1 IUCXYMVKFYXONK-MSOLQXFVSA-N 369286 (2R)-4-[6-(4-fluorophenyl)thieno[3,2- d]pyrimidin-4-yl]-N-[(1S)-1-(3- methoxyphenyl)ethyl]-2-methyl- piperazine-1-carboxamide::US10227357, Compound P-0600 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369286 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369286&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 73388893 402366080 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729586 C[C@H](NC(=O)N1CCN(C[C@H]1C)c1ncnc2cc(sc12)-c1ccc(F)cc1)c1ccc(F)cc1 InChI=1S/C26H25F2N5OS/c1-16-14-32(11-12-33(16)26(34)31-17(2)18-3-7-20(27)8-4-18)25-24-22(29-15-30-25)13-23(35-24)19-5-9-21(28)10-6-19/h3-10,13,15-17H,11-12,14H2,1-2H3,(H,31,34)/t16-,17+/m1/s1 OFJCPJVLANPLDK-SJORKVTESA-N 369287 (2R)-N-[(1S)-1-(4-fluorophenyl)ethyl]-4-[6- (4-fluorophenyl)thieno[3,2-d]pyrimidin-4- yl]-2-methyl-piperazine-1-carboxamide::US10227357, Compound P-0601 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369287 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369287&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 73388894 402366081 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729587 C[C@@H]1CN(CCN1C(=O)NCc1ccc(F)cc1)c1ncnc2cc(sc12)-c1ccc(F)cc1 InChI=1S/C25H23F2N5OS/c1-16-14-31(10-11-32(16)25(33)28-13-17-2-6-19(26)7-3-17)24-23-21(29-15-30-24)12-22(34-23)18-4-8-20(27)9-5-18/h2-9,12,15-16H,10-11,13-14H2,1H3,(H,28,33)/t16-/m1/s1 NWGXIVGGOZCRNF-MRXNPFEDSA-N 369288 (2R)-N-[(4-fluorophenyl)methyl]-4-[6-(4- fluorophenyl)thieno[3,2-d]pyrimidin-4-yl]- 2-methyl-piperazine-1-carboxamide::US10227357, Compound P-0602 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369288 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369288&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 73388895 402366082 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729588 C[C@@H]1CN(CCN1C(=O)NCc1ccc(F)cc1)c1ncnc2cc(sc12)-c1ccc(F)cc1 InChI=1S/C25H23F2N5OS/c1-16-14-31(10-11-32(16)25(33)28-13-17-2-6-19(26)7-3-17)24-23-21(29-15-30-24)12-22(34-23)18-4-8-20(27)9-5-18/h2-9,12,15-16H,10-11,13-14H2,1H3,(H,28,33)/t16-/m1/s1 NWGXIVGGOZCRNF-MRXNPFEDSA-N 369288 (2R)-N-[(4-fluorophenyl)methyl]-4-[6-(4- fluorophenyl)thieno[3,2-d]pyrimidin-4-yl]- 2-methyl-piperazine-1-carboxamide::US10227357, Compound P-0602 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369288 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369288&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 73388895 402366082 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729589 C[C@H](NC(=O)N1CCC(CC1)c1ncnc2cc(sc12)-c1cn(C)nc1C)c1ccc(F)cc1 InChI=1S/C25H27FN6OS/c1-15(17-4-6-19(26)7-5-17)29-25(33)32-10-8-18(9-11-32)23-24-21(27-14-28-23)12-22(34-24)20-13-31(3)30-16(20)2/h4-7,12-15,18H,8-11H2,1-3H3,(H,29,33)/t15-/m0/s1 GPOLEKVXLGLFKE-HNNXBMFYSA-N 369289 4-[6-(1,3-dimethylpyrazol-4-yl)thieno[3,2- d]pyrimidin-4-yl]-N-[(1S)-1-(4- fluorophenyl)ethyl]piperidine-1- carboxamide::US10227357, Compound P-0603 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369289 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369289&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 73388896 402366083 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729590 C[C@H](NC(=O)N1CCC(CC1)c1ncnc2cc(sc12)-c1cn(C)nc1C)c1ccc(F)cc1 InChI=1S/C25H27FN6OS/c1-15(17-4-6-19(26)7-5-17)29-25(33)32-10-8-18(9-11-32)23-24-21(27-14-28-23)12-22(34-24)20-13-31(3)30-16(20)2/h4-7,12-15,18H,8-11H2,1-3H3,(H,29,33)/t15-/m0/s1 GPOLEKVXLGLFKE-HNNXBMFYSA-N 369289 4-[6-(1,3-dimethylpyrazol-4-yl)thieno[3,2- d]pyrimidin-4-yl]-N-[(1S)-1-(4- fluorophenyl)ethyl]piperidine-1- carboxamide::US10227357, Compound P-0603 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369289 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369289&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 73388896 402366083 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729591 Cc1nn(C)cc1-c1cc2ncnc(C3CCN(CC3)C(=O)NCc3ccc(F)cc3)c2s1 InChI=1S/C24H25FN6OS/c1-15-19(13-30(2)29-15)21-11-20-23(33-21)22(28-14-27-20)17-7-9-31(10-8-17)24(32)26-12-16-3-5-18(25)6-4-16/h3-6,11,13-14,17H,7-10,12H2,1-2H3,(H,26,32) QLNAWAPWQLWSBT-UHFFFAOYSA-N 369290 4-[6-(1,3-dimethylpyrazol-4-yl)thieno[3,2- d]pyrimidin-4-yl]-N-[(4- fluorophenyl)methyl]piperidine-1- carboxamide::US10227357, Compound P-0604 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369290 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369290&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90003732 402366084 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729592 Cc1nn(C)cc1-c1cc2ncnc(C3CCN(CC3)C(=O)NCc3ccc(F)cc3)c2s1 InChI=1S/C24H25FN6OS/c1-15-19(13-30(2)29-15)21-11-20-23(33-21)22(28-14-27-20)17-7-9-31(10-8-17)24(32)26-12-16-3-5-18(25)6-4-16/h3-6,11,13-14,17H,7-10,12H2,1-2H3,(H,26,32) QLNAWAPWQLWSBT-UHFFFAOYSA-N 369290 4-[6-(1,3-dimethylpyrazol-4-yl)thieno[3,2- d]pyrimidin-4-yl]-N-[(4- fluorophenyl)methyl]piperidine-1- carboxamide::US10227357, Compound P-0604 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369290 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369290&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90003732 402366084 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729593 COc1cccc(c1)[C@@H](C)NC(=O)N1CCN(C[C@H]1C)c1ncnc2cc(sc12)-c1ccc(F)cc1 InChI=1S/C27H28FN5O2S/c1-17-15-32(11-12-33(17)27(34)31-18(2)20-5-4-6-22(13-20)35-3)26-25-23(29-16-30-26)14-24(36-25)19-7-9-21(28)10-8-19/h4-10,13-14,16-18H,11-12,15H2,1-3H3,(H,31,34)/t17-,18-/m1/s1 IUCXYMVKFYXONK-QZTJIDSGSA-N 369291 (2R)-4-[6-(4-fluorophenyl)thieno[3,2- d]pyrimidin-4-yl]-N-[(1R)-1-(3- methoxyphenyl)ethyl]-2-methyl- piperazine-1-carboxamide::US10227357, Compound P-0605 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369291 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369291&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 73388722 402366085 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729594 COc1cccc(c1)[C@@H](C)NC(=O)N1CCN(C[C@H]1C)c1ncnc2cc(sc12)-c1ccc(F)cc1 InChI=1S/C27H28FN5O2S/c1-17-15-32(11-12-33(17)27(34)31-18(2)20-5-4-6-22(13-20)35-3)26-25-23(29-16-30-26)14-24(36-25)19-7-9-21(28)10-8-19/h4-10,13-14,16-18H,11-12,15H2,1-3H3,(H,31,34)/t17-,18-/m1/s1 IUCXYMVKFYXONK-QZTJIDSGSA-N 369291 (2R)-4-[6-(4-fluorophenyl)thieno[3,2- d]pyrimidin-4-yl]-N-[(1R)-1-(3- methoxyphenyl)ethyl]-2-methyl- piperazine-1-carboxamide::US10227357, Compound P-0605 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369291 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369291&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 73388722 402366085 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729595 C[C@@H](NC(=O)N1CCN(C[C@H]1C)c1ncnc2cc(sc12)-c1ccc(F)cc1)c1ccc(F)cc1 InChI=1S/C26H25F2N5OS/c1-16-14-32(11-12-33(16)26(34)31-17(2)18-3-7-20(27)8-4-18)25-24-22(29-15-30-25)13-23(35-24)19-5-9-21(28)10-6-19/h3-10,13,15-17H,11-12,14H2,1-2H3,(H,31,34)/t16-,17-/m1/s1 OFJCPJVLANPLDK-IAGOWNOFSA-N 369292 (2R)-N-[(1R)-1-(4-fluorophenyl)ethyl]-4-[6- (4-fluorophenyl)thieno[3,2-d]pyrimidin-4- yl]-2-methyl-piperazine-1-carboxamide::US10227357, Compound P-0606 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369292 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369292&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 73388723 402366086 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729596 C[C@@H](NC(=O)N1CCN(C[C@H]1C)c1ncnc2cc(sc12)-c1ccc(F)cc1)c1ccc(F)cc1 InChI=1S/C26H25F2N5OS/c1-16-14-32(11-12-33(16)26(34)31-17(2)18-3-7-20(27)8-4-18)25-24-22(29-15-30-25)13-23(35-24)19-5-9-21(28)10-6-19/h3-10,13,15-17H,11-12,14H2,1-2H3,(H,31,34)/t16-,17-/m1/s1 OFJCPJVLANPLDK-IAGOWNOFSA-N 369292 (2R)-N-[(1R)-1-(4-fluorophenyl)ethyl]-4-[6- (4-fluorophenyl)thieno[3,2-d]pyrimidin-4- yl]-2-methyl-piperazine-1-carboxamide::US10227357, Compound P-0606 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369292 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369292&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 73388723 402366086 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729597 Cc1nn(C)cc1-c1cc2ncnc(C3CCNCC3)c2s1 InChI=1S/C16H19N5S/c1-10-12(8-21(2)20-10)14-7-13-16(22-14)15(19-9-18-13)11-3-5-17-6-4-11/h7-9,11,17H,3-6H2,1-2H3 BXQPNKQCBWXZOB-UHFFFAOYSA-N 369293 6-(1,3-dimethylpyrazol-4-yl)-4-(4- piperidyl)thieno[3,2-d]pyrimidine::US10227357, Compound P-0607 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369293 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369293&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 73388806 402366087 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729598 Cc1nn(C)cc1-c1cc2ncnc(C3CCNCC3)c2s1 InChI=1S/C16H19N5S/c1-10-12(8-21(2)20-10)14-7-13-16(22-14)15(19-9-18-13)11-3-5-17-6-4-11/h7-9,11,17H,3-6H2,1-2H3 BXQPNKQCBWXZOB-UHFFFAOYSA-N 369293 6-(1,3-dimethylpyrazol-4-yl)-4-(4- piperidyl)thieno[3,2-d]pyrimidine::US10227357, Compound P-0607 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369293 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369293&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 73388806 402366087 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729599 COc1cccc(c1)[C@@H](C)NC(=O)N1CCN(C[C@H]1C)c1ncnc2cc(sc12)-c1cn(C)nc1C InChI=1S/C26H31N7O2S/c1-16-13-32(9-10-33(16)26(34)29-17(2)19-7-6-8-20(11-19)35-5)25-24-22(27-15-28-25)12-23(36-24)21-14-31(4)30-18(21)3/h6-8,11-12,14-17H,9-10,13H2,1-5H3,(H,29,34)/t16-,17-/m1/s1 AKZDLPYXTXCHDN-IAGOWNOFSA-N 369294 (2R)-4-[6-(1,3-dimethylpyrazol-4- yl)thieno[3,2-d]pyrimidin-4-yl]-N-[(1R)-1- (3-methoxyphenyl)ethyl]-2-methyl- piperazine-1-carboxamide::US10227357, Compound P-0608 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369294 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369294&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 73388724 402366088 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729600 COc1cccc(c1)[C@@H](C)NC(=O)N1CCN(C[C@H]1C)c1ncnc2cc(sc12)-c1cn(C)nc1C InChI=1S/C26H31N7O2S/c1-16-13-32(9-10-33(16)26(34)29-17(2)19-7-6-8-20(11-19)35-5)25-24-22(27-15-28-25)12-23(36-24)21-14-31(4)30-18(21)3/h6-8,11-12,14-17H,9-10,13H2,1-5H3,(H,29,34)/t16-,17-/m1/s1 AKZDLPYXTXCHDN-IAGOWNOFSA-N 369294 (2R)-4-[6-(1,3-dimethylpyrazol-4- yl)thieno[3,2-d]pyrimidin-4-yl]-N-[(1R)-1- (3-methoxyphenyl)ethyl]-2-methyl- piperazine-1-carboxamide::US10227357, Compound P-0608 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369294 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369294&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 73388724 402366088 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729601 C[C@@H](NC(=O)N1CCN(C[C@H]1C)c1ncnc2cc(sc12)-c1cn(C)nc1C)c1ccc(F)cc1 InChI=1S/C25H28FN7OS/c1-15-12-32(9-10-33(15)25(34)29-16(2)18-5-7-19(26)8-6-18)24-23-21(27-14-28-24)11-22(35-23)20-13-31(4)30-17(20)3/h5-8,11,13-16H,9-10,12H2,1-4H3,(H,29,34)/t15-,16-/m1/s1 IELRNEVNMCGBFV-HZPDHXFCSA-N 369295 (2R)-4-[6-(1,3-dimethylpyrazol-4- yl)thieno[3,2-d]pyrimidin-4-yl]-N-[(1R)-1- (4-fluorophenyl)ethyl]-2-methyl- piperazine-1-carboxamide::US10227357, Compound P-0609 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369295 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369295&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 73388725 402366089 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729602 C[C@@H](NC(=O)N1CCN(C[C@H]1C)c1ncnc2cc(sc12)-c1cn(C)nc1C)c1ccc(F)cc1 InChI=1S/C25H28FN7OS/c1-15-12-32(9-10-33(15)25(34)29-16(2)18-5-7-19(26)8-6-18)24-23-21(27-14-28-24)11-22(35-23)20-13-31(4)30-17(20)3/h5-8,11,13-16H,9-10,12H2,1-4H3,(H,29,34)/t15-,16-/m1/s1 IELRNEVNMCGBFV-HZPDHXFCSA-N 369295 (2R)-4-[6-(1,3-dimethylpyrazol-4- yl)thieno[3,2-d]pyrimidin-4-yl]-N-[(1R)-1- (4-fluorophenyl)ethyl]-2-methyl- piperazine-1-carboxamide::US10227357, Compound P-0609 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369295 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369295&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 73388725 402366089 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729603 C[C@@H]1CN(CCN1C(=O)NCc1ccc(F)cc1)c1ncnc2cc(sc12)-c1cn(C)nc1C InChI=1S/C24H26FN7OS/c1-15-12-31(8-9-32(15)24(33)26-11-17-4-6-18(25)7-5-17)23-22-20(27-14-28-23)10-21(34-22)19-13-30(3)29-16(19)2/h4-7,10,13-15H,8-9,11-12H2,1-3H3,(H,26,33)/t15-/m1/s1 KPTRXAFJAWLXNC-OAHLLOKOSA-N 369296 (2R)-4-[6-(1,3-dimethylpyrazol-4- yl)thieno[3,2-d]pyrimidin-4-yl]-N-[(4- fluorophenyl)methyl]-2-methyl- piperazine-1-carboxamide::US10227357, Compound P-0610 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369296 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369296&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 73388807 402366090 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729604 C[C@@H]1CN(CCN1C(=O)NCc1ccc(F)cc1)c1ncnc2cc(sc12)-c1cn(C)nc1C InChI=1S/C24H26FN7OS/c1-15-12-31(8-9-32(15)24(33)26-11-17-4-6-18(25)7-5-17)23-22-20(27-14-28-23)10-21(34-22)19-13-30(3)29-16(19)2/h4-7,10,13-15H,8-9,11-12H2,1-3H3,(H,26,33)/t15-/m1/s1 KPTRXAFJAWLXNC-OAHLLOKOSA-N 369296 (2R)-4-[6-(1,3-dimethylpyrazol-4- yl)thieno[3,2-d]pyrimidin-4-yl]-N-[(4- fluorophenyl)methyl]-2-methyl- piperazine-1-carboxamide::US10227357, Compound P-0610 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369296 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369296&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 73388807 402366090 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729605 Cc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)-c1ncnc2cc(sc12)C1=CCNCC1 InChI=1S/C24H22N4O2S2/c1-16-2-8-20(9-3-16)32(29,30)28-19-6-4-18(5-7-19)23-24-21(26-15-27-23)14-22(31-24)17-10-12-25-13-11-17/h2-10,14-15,25,28H,11-13H2,1H3 FYZYXBKRRNJMPR-UHFFFAOYSA-N 369297 4-methyl-N-[4-[6-(1,2,3,6- tetrahydropyridin-4-yl)thieno[3,2- d]pyrimidin-4- yl]phenyl]benzenesulfonamide::US10227357, Compound P-0611 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369297 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369297&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 73388808 402366091 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729606 Cc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)-c1ncnc2cc(sc12)C1=CCNCC1 InChI=1S/C24H22N4O2S2/c1-16-2-8-20(9-3-16)32(29,30)28-19-6-4-18(5-7-19)23-24-21(26-15-27-23)14-22(31-24)17-10-12-25-13-11-17/h2-10,14-15,25,28H,11-13H2,1H3 FYZYXBKRRNJMPR-UHFFFAOYSA-N 369297 4-methyl-N-[4-[6-(1,2,3,6- tetrahydropyridin-4-yl)thieno[3,2- d]pyrimidin-4- yl]phenyl]benzenesulfonamide::US10227357, Compound P-0611 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369297 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369297&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 73388808 402366091 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729607 Cc1nn(C)cc1-c1cc2ncnc(C3=CCN(CC3)C(=O)Nc3ccc(Cl)cc3)c2s1 InChI=1S/C23H21ClN6OS/c1-14-18(12-29(2)28-14)20-11-19-22(32-20)21(26-13-25-19)15-7-9-30(10-8-15)23(31)27-17-5-3-16(24)4-6-17/h3-7,11-13H,8-10H2,1-2H3,(H,27,31) IVMVDFSLLZSRTB-UHFFFAOYSA-N 369298 N-(4-chlorophenyl)-4-[6-(1,3- dimethylpyrazol-4-yl)thieno[3,2- d]pyrimidin-4-yl]-3,6-dihydro-2H-pyridine- 1-carboxamide::US10227357, Compound P-0612 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369298 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369298&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 73388633 402366092 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729608 Cc1nn(C)cc1-c1cc2ncnc(C3=CCN(CC3)C(=O)Nc3ccc(Cl)cc3)c2s1 InChI=1S/C23H21ClN6OS/c1-14-18(12-29(2)28-14)20-11-19-22(32-20)21(26-13-25-19)15-7-9-30(10-8-15)23(31)27-17-5-3-16(24)4-6-17/h3-7,11-13H,8-10H2,1-2H3,(H,27,31) IVMVDFSLLZSRTB-UHFFFAOYSA-N 369298 N-(4-chlorophenyl)-4-[6-(1,3- dimethylpyrazol-4-yl)thieno[3,2- d]pyrimidin-4-yl]-3,6-dihydro-2H-pyridine- 1-carboxamide::US10227357, Compound P-0612 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369298 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369298&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 73388633 402366092 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729609 Cc1nn(C)cc1-c1cc2ncnc(C3=CCN(CC3)C(=O)NCc3ccc(F)cc3)c2s1 InChI=1S/C24H23FN6OS/c1-15-19(13-30(2)29-15)21-11-20-23(33-21)22(28-14-27-20)17-7-9-31(10-8-17)24(32)26-12-16-3-5-18(25)6-4-16/h3-7,11,13-14H,8-10,12H2,1-2H3,(H,26,32) IEEJCOXTDPKKQB-UHFFFAOYSA-N 369299 4-[6-(1,3-dimethylpyrazol-4-yl)thieno[3,2- d]pyrimidin-4-yl]-N-[(4- fluorophenyl)methyl]-3,6-dihydro-2H- pyridine-1-carboxamide::US10227357, Compound P-0613 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369299 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369299&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 73388634 402366093 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729610 Cc1nn(C)cc1-c1cc2ncnc(C3=CCN(CC3)C(=O)NCc3ccc(F)cc3)c2s1 InChI=1S/C24H23FN6OS/c1-15-19(13-30(2)29-15)21-11-20-23(33-21)22(28-14-27-20)17-7-9-31(10-8-17)24(32)26-12-16-3-5-18(25)6-4-16/h3-7,11,13-14H,8-10,12H2,1-2H3,(H,26,32) IEEJCOXTDPKKQB-UHFFFAOYSA-N 369299 4-[6-(1,3-dimethylpyrazol-4-yl)thieno[3,2- d]pyrimidin-4-yl]-N-[(4- fluorophenyl)methyl]-3,6-dihydro-2H- pyridine-1-carboxamide::US10227357, Compound P-0613 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369299 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369299&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 73388634 402366093 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729611 Cc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)-c1ncnc2cc(sc12)C1=CCN(CC1)C(=O)OC(C)(C)C InChI=1S/C29H30N4O4S2/c1-19-5-11-23(12-6-19)39(35,36)32-22-9-7-21(8-10-22)26-27-24(30-18-31-26)17-25(38-27)20-13-15-33(16-14-20)28(34)37-29(2,3)4/h5-13,17-18,32H,14-16H2,1-4H3 LCLLDLFTQZZRHL-UHFFFAOYSA-N 369300 US10227357, Compound P-0614::tert-butyl 4-[4-[4-(p- tolylsulfonylamino)phenyl]thieno[3,2- d]pyrimidin-6-yl]-3,6-dihydro-2H-pyridine- 1-carboxylate Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369300 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369300&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 86718064 402366094 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729612 Cc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)-c1ncnc2cc(sc12)C1=CCN(CC1)C(=O)OC(C)(C)C InChI=1S/C29H30N4O4S2/c1-19-5-11-23(12-6-19)39(35,36)32-22-9-7-21(8-10-22)26-27-24(30-18-31-26)17-25(38-27)20-13-15-33(16-14-20)28(34)37-29(2,3)4/h5-13,17-18,32H,14-16H2,1-4H3 LCLLDLFTQZZRHL-UHFFFAOYSA-N 369300 US10227357, Compound P-0614::tert-butyl 4-[4-[4-(p- tolylsulfonylamino)phenyl]thieno[3,2- d]pyrimidin-6-yl]-3,6-dihydro-2H-pyridine- 1-carboxylate Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369300 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369300&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 86718064 402366094 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729613 Fc1ccc(CNC(=O)N2CCN(CC2)c2ncnc3cc(sc23)C2=CCNCC2)cc1 InChI=1S/C23H25FN6OS/c24-18-3-1-16(2-4-18)14-26-23(31)30-11-9-29(10-12-30)22-21-19(27-15-28-22)13-20(32-21)17-5-7-25-8-6-17/h1-5,13,15,25H,6-12,14H2,(H,26,31) XZMUZGSILSXLPV-UHFFFAOYSA-N 369301 N-[(4-fluorophenyl)methyl]-4-[6-(1,2,3,6- tetrahydropyridin-4-yl)thieno[3,2- d]pyrimidin-4-yl]piperazine-1- carboxamide::US10227357, Compound P-0615 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369301 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369301&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90001329 402366095 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729614 Fc1ccc(CNC(=O)N2CCN(CC2)c2ncnc3cc(sc23)C2=CCNCC2)cc1 InChI=1S/C23H25FN6OS/c24-18-3-1-16(2-4-18)14-26-23(31)30-11-9-29(10-12-30)22-21-19(27-15-28-22)13-20(32-21)17-5-7-25-8-6-17/h1-5,13,15,25H,6-12,14H2,(H,26,31) XZMUZGSILSXLPV-UHFFFAOYSA-N 369301 N-[(4-fluorophenyl)methyl]-4-[6-(1,2,3,6- tetrahydropyridin-4-yl)thieno[3,2- d]pyrimidin-4-yl]piperazine-1- carboxamide::US10227357, Compound P-0615 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369301 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369301&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90001329 402366095 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729615 CC(C)(C)OC(=O)N1CCC(=CC1)c1cc2ncnc(N3CCN(CC3)C(=O)NCc3ccc(F)cc3)c2s1 InChI=1S/C28H33FN6O3S/c1-28(2,3)38-27(37)35-10-8-20(9-11-35)23-16-22-24(39-23)25(32-18-31-22)33-12-14-34(15-13-33)26(36)30-17-19-4-6-21(29)7-5-19/h4-8,16,18H,9-15,17H2,1-3H3,(H,30,36) CBFAZBCIQSXQQA-UHFFFAOYSA-N 369302 US10227357, Compound P-0616::tert-butyl 4-[4-[4-[(4- fluorophenyl)methylcarbamoyl]piperazin- 1-yl]thieno[3,2-d]pyrimidin-6-yl]-3,6- dihydro-2H-pyridine-1-carboxylate Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369302 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369302&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90001201 402366096 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729616 CC(C)(C)OC(=O)N1CCC(=CC1)c1cc2ncnc(N3CCN(CC3)C(=O)NCc3ccc(F)cc3)c2s1 InChI=1S/C28H33FN6O3S/c1-28(2,3)38-27(37)35-10-8-20(9-11-35)23-16-22-24(39-23)25(32-18-31-22)33-12-14-34(15-13-33)26(36)30-17-19-4-6-21(29)7-5-19/h4-8,16,18H,9-15,17H2,1-3H3,(H,30,36) CBFAZBCIQSXQQA-UHFFFAOYSA-N 369302 US10227357, Compound P-0616::tert-butyl 4-[4-[4-[(4- fluorophenyl)methylcarbamoyl]piperazin- 1-yl]thieno[3,2-d]pyrimidin-6-yl]-3,6- dihydro-2H-pyridine-1-carboxylate Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369302 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369302&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90001201 402366096 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729617 Cn1cc(cn1)-c1cc2ncnc(N3CC(C)(C)NC(C)(C)C3)c2s1 InChI=1S/C18H24N6S/c1-17(2)9-24(10-18(3,4)22-17)16-15-13(19-11-20-16)6-14(25-15)12-7-21-23(5)8-12/h6-8,11,22H,9-10H2,1-5H3 SZYWGPORBZAISO-UHFFFAOYSA-N 369303 6-(1-methylpyrazol-4-yl)-4-(2,2,6,6- tetramethyl-1,3-dihydropyridin-4- yl)thieno[3,2-d]pyrimidine::US10227357, Compound P-0617 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369303 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369303&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 73388635 402366097 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729618 Cn1cc(cn1)-c1cc2ncnc(N3CC(C)(C)NC(C)(C)C3)c2s1 InChI=1S/C18H24N6S/c1-17(2)9-24(10-18(3,4)22-17)16-15-13(19-11-20-16)6-14(25-15)12-7-21-23(5)8-12/h6-8,11,22H,9-10H2,1-5H3 SZYWGPORBZAISO-UHFFFAOYSA-N 369303 6-(1-methylpyrazol-4-yl)-4-(2,2,6,6- tetramethyl-1,3-dihydropyridin-4- yl)thieno[3,2-d]pyrimidine::US10227357, Compound P-0617 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369303 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369303&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 73388635 402366097 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729619 Cc1nn(C)c(C)c1-c1cc2ncnc(N3CCN(CC3)C(=O)NCc3ccc(F)cc3)c2s1 InChI=1S/C24H26FN7OS/c1-15-21(16(2)30(3)29-15)20-12-19-22(34-20)23(28-14-27-19)31-8-10-32(11-9-31)24(33)26-13-17-4-6-18(25)7-5-17/h4-7,12,14H,8-11,13H2,1-3H3,(H,26,33) NTQYKDUYLJCWMM-UHFFFAOYSA-N 369304 N-[(4-fluorophenyl)methyl]-4-[6-(1,3,5- trimethylpyrazol-4-yl)thieno[3,2- d]pyrimidin-4-yl]piperazine-1- carboxamide::US10227357, Compound P-0618 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369304 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369304&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90002942 402366098 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729620 Cc1nn(C)c(C)c1-c1cc2ncnc(N3CCN(CC3)C(=O)NCc3ccc(F)cc3)c2s1 InChI=1S/C24H26FN7OS/c1-15-21(16(2)30(3)29-15)20-12-19-22(34-20)23(28-14-27-19)31-8-10-32(11-9-31)24(33)26-13-17-4-6-18(25)7-5-17/h4-7,12,14H,8-11,13H2,1-3H3,(H,26,33) NTQYKDUYLJCWMM-UHFFFAOYSA-N 369304 N-[(4-fluorophenyl)methyl]-4-[6-(1,3,5- trimethylpyrazol-4-yl)thieno[3,2- d]pyrimidin-4-yl]piperazine-1- carboxamide::US10227357, Compound P-0618 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369304 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369304&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90002942 402366098 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729621 Cc1nn(C)cc1-c1cc2ncnc(N3CCN(CC3)C(=O)NCc3ccc(F)cc3)c2s1 InChI=1S/C23H24FN7OS/c1-15-18(13-29(2)28-15)20-11-19-21(33-20)22(27-14-26-19)30-7-9-31(10-8-30)23(32)25-12-16-3-5-17(24)6-4-16/h3-6,11,13-14H,7-10,12H2,1-2H3,(H,25,32) LIJRWGTWPYHSBZ-UHFFFAOYSA-N 369305 4-[6-(1,3-dimethylpyrazol-4-yl)thieno[3,2- d]pyrimidin-4-yl]-N-[(4- fluorophenyl)methyl]piperazine-1- carboxamide::US10227357, Compound P-0619 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369305 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369305&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 73388637 402366099 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729622 Cc1nn(C)cc1-c1cc2ncnc(N3CCN(CC3)C(=O)NCc3ccc(F)cc3)c2s1 InChI=1S/C23H24FN7OS/c1-15-18(13-29(2)28-15)20-11-19-21(33-20)22(27-14-26-19)30-7-9-31(10-8-30)23(32)25-12-16-3-5-17(24)6-4-16/h3-6,11,13-14H,7-10,12H2,1-2H3,(H,25,32) LIJRWGTWPYHSBZ-UHFFFAOYSA-N 369305 4-[6-(1,3-dimethylpyrazol-4-yl)thieno[3,2- d]pyrimidin-4-yl]-N-[(4- fluorophenyl)methyl]piperazine-1- carboxamide::US10227357, Compound P-0619 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369305 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369305&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 73388637 402366099 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729623 Cc1c(cnn1C)-c1cc2ncnc(N3CCN(CC3)C(=O)NCc3ccc(F)cc3)c2s1 InChI=1S/C23H24FN7OS/c1-15-18(13-28-29(15)2)20-11-19-21(33-20)22(27-14-26-19)30-7-9-31(10-8-30)23(32)25-12-16-3-5-17(24)6-4-16/h3-6,11,13-14H,7-10,12H2,1-2H3,(H,25,32) VLWUPHSZUDJJNM-UHFFFAOYSA-N 369306 4-[6-(1,5-dimethylpyrazol-4-yl)thieno[3,2- d]pyrimidin-4-yl]-N-[(4- fluorophenyl)methyl]piperazine-1- carboxamide::US10227357, Compound P-0620 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369306 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369306&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 73388550 402366100 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729624 Cc1c(cnn1C)-c1cc2ncnc(N3CCN(CC3)C(=O)NCc3ccc(F)cc3)c2s1 InChI=1S/C23H24FN7OS/c1-15-18(13-28-29(15)2)20-11-19-21(33-20)22(27-14-26-19)30-7-9-31(10-8-30)23(32)25-12-16-3-5-17(24)6-4-16/h3-6,11,13-14H,7-10,12H2,1-2H3,(H,25,32) VLWUPHSZUDJJNM-UHFFFAOYSA-N 369306 4-[6-(1,5-dimethylpyrazol-4-yl)thieno[3,2- d]pyrimidin-4-yl]-N-[(4- fluorophenyl)methyl]piperazine-1- carboxamide::US10227357, Compound P-0620 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369306 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369306&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 73388550 402366100 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729625 Cn1cc(cn1)-c1cc2ncnc(-c3ccc(N)nc3)c2s1 InChI=1S/C15H12N6S/c1-21-7-10(6-20-21)12-4-11-15(22-12)14(19-8-18-11)9-2-3-13(16)17-5-9/h2-8H,1H3,(H2,16,17) XJBBOVGCMPOJES-UHFFFAOYSA-N 369307 5-[6-(1-methylpyrazol-4-yl)thieno[3,2- d]pyrimidin-4-yl]pyridin-2-amine::US10227357, Compound P-0621 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369307 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369307&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114482 402366101 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729626 Cn1cc(cn1)-c1cc2ncnc(-c3ccc(N)nc3)c2s1 InChI=1S/C15H12N6S/c1-21-7-10(6-20-21)12-4-11-15(22-12)14(19-8-18-11)9-2-3-13(16)17-5-9/h2-8H,1H3,(H2,16,17) XJBBOVGCMPOJES-UHFFFAOYSA-N 369307 5-[6-(1-methylpyrazol-4-yl)thieno[3,2- d]pyrimidin-4-yl]pyridin-2-amine::US10227357, Compound P-0621 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369307 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369307&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114482 402366101 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729627 Cc1cc2ncnc(-c3ccc(NS(C)(=O)=O)cc3)c2s1 InChI=1S/C14H13N3O2S2/c1-9-7-12-14(20-9)13(16-8-15-12)10-3-5-11(6-4-10)17-21(2,18)19/h3-8,17H,1-2H3 WURYGUPDBHNWMM-UHFFFAOYSA-N 369308 N-[4-(6-methylthieno[3,2-d]pyrimidin-4- yl)phenyl]methanesulfonamide::US10227357, Compound P-0622 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369308 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369308&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90002047 402366102 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729628 Cc1cc2ncnc(-c3ccc(NS(C)(=O)=O)cc3)c2s1 InChI=1S/C14H13N3O2S2/c1-9-7-12-14(20-9)13(16-8-15-12)10-3-5-11(6-4-10)17-21(2,18)19/h3-8,17H,1-2H3 WURYGUPDBHNWMM-UHFFFAOYSA-N 369308 N-[4-(6-methylthieno[3,2-d]pyrimidin-4- yl)phenyl]methanesulfonamide::US10227357, Compound P-0622 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369308 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369308&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90002047 402366102 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729629 Cc1cc2ncnc(-c3ccc(NS(=O)(=O)c4ccc(C)cc4)cc3)c2s1 InChI=1S/C20H17N3O2S2/c1-13-3-9-17(10-4-13)27(24,25)23-16-7-5-15(6-8-16)19-20-18(21-12-22-19)11-14(2)26-20/h3-12,23H,1-2H3 CANHDHZUVXPLEL-UHFFFAOYSA-N 369309 4-methyl-N-[4-(6-methylthieno[3,2- d]pyrimidin-4- yl)phenyl]benzenesulfonamide::US10227357, Compound P-0623 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369309 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369309&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 73388552 402366103 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729630 Cc1cc2ncnc(-c3ccc(NS(=O)(=O)c4ccc(C)cc4)cc3)c2s1 InChI=1S/C20H17N3O2S2/c1-13-3-9-17(10-4-13)27(24,25)23-16-7-5-15(6-8-16)19-20-18(21-12-22-19)11-14(2)26-20/h3-12,23H,1-2H3 CANHDHZUVXPLEL-UHFFFAOYSA-N 369309 4-methyl-N-[4-(6-methylthieno[3,2- d]pyrimidin-4- yl)phenyl]benzenesulfonamide::US10227357, Compound P-0623 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369309 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369309&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 73388552 402366103 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729631 Fc1ccc(CNC(=O)N2CCN(CC2)c2ncnc3cc(sc23)-c2cnn(CCN3CCOCC3)c2)cc1 InChI=1S/C27H31FN8O2S/c28-22-3-1-20(2-4-22)16-29-27(37)35-8-6-34(7-9-35)26-25-23(30-19-31-26)15-24(39-25)21-17-32-36(18-21)10-5-33-11-13-38-14-12-33/h1-4,15,17-19H,5-14,16H2,(H,29,37) HJZKPJUJQJAIFI-UHFFFAOYSA-N 369310 N-[(4-fluorophenyl)methyl]-4-[6-[1-(2- morpholinoethyl)pyrazol-4-yl]thieno[3,2- d]pyrimidin-4-yl]piperazine-1- carboxamide::US10227357, Compound P-0624 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369310 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369310&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 73388553 402366104 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729632 Fc1ccc(CNC(=O)N2CCN(CC2)c2ncnc3cc(sc23)-c2cnn(CCN3CCOCC3)c2)cc1 InChI=1S/C27H31FN8O2S/c28-22-3-1-20(2-4-22)16-29-27(37)35-8-6-34(7-9-35)26-25-23(30-19-31-26)15-24(39-25)21-17-32-36(18-21)10-5-33-11-13-38-14-12-33/h1-4,15,17-19H,5-14,16H2,(H,29,37) HJZKPJUJQJAIFI-UHFFFAOYSA-N 369310 N-[(4-fluorophenyl)methyl]-4-[6-[1-(2- morpholinoethyl)pyrazol-4-yl]thieno[3,2- d]pyrimidin-4-yl]piperazine-1- carboxamide::US10227357, Compound P-0624 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369310 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369310&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 73388553 402366104 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729633 Cc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)-c1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccccc3)c2s1 InChI=1S/C30H28N6O3S2/c1-21-7-13-25(14-8-21)41(38,39)34-24-11-9-22(10-12-24)27-19-26-28(40-27)29(32-20-31-26)35-15-17-36(18-16-35)30(37)33-23-5-3-2-4-6-23/h2-14,19-20,34H,15-18H2,1H3,(H,33,37) UOZIOSPNCDGLKX-UHFFFAOYSA-N 369311 N-phenyl-4-[6-[4-(p- tolylsulfonylamino)phenyl]thieno[3,2- d]pyrimidin-4-yl]piperazine-1- carboxamide::US10227357, Compound P-0625 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369311 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369311&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90001577 402366105 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729634 Cn1cc(cn1)-c1cc2ncnc(N3CCN(CC3)C(=O)NCc3ccccc3)c2s1 InChI=1S/C22H23N7OS/c1-27-14-17(13-26-27)19-11-18-20(31-19)21(25-15-24-18)28-7-9-29(10-8-28)22(30)23-12-16-5-3-2-4-6-16/h2-6,11,13-15H,7-10,12H2,1H3,(H,23,30) YUOSXTLNVRVHEN-UHFFFAOYSA-N 369312 N-benzyl-4-[6-(1-methylpyrazol-4- yl)thieno[3,2-d]pyrimidin-4-yl]piperazine- 1-carboxamide::US10227357, Compound P-0626 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369312 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369312&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 73388554 402366106 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729635 Cn1cc(cn1)-c1cc2ncnc(N3CCN(CC3)C(=O)NCc3ccccc3)c2s1 InChI=1S/C22H23N7OS/c1-27-14-17(13-26-27)19-11-18-20(31-19)21(25-15-24-18)28-7-9-29(10-8-28)22(30)23-12-16-5-3-2-4-6-16/h2-6,11,13-15H,7-10,12H2,1H3,(H,23,30) YUOSXTLNVRVHEN-UHFFFAOYSA-N 369312 N-benzyl-4-[6-(1-methylpyrazol-4- yl)thieno[3,2-d]pyrimidin-4-yl]piperazine- 1-carboxamide::US10227357, Compound P-0626 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369312 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369312&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 73388554 402366106 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729636 Cn1cc(cn1)-c1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccccc3)c2s1 InChI=1S/C21H21N7OS/c1-26-13-15(12-24-26)18-11-17-19(30-18)20(23-14-22-17)27-7-9-28(10-8-27)21(29)25-16-5-3-2-4-6-16/h2-6,11-14H,7-10H2,1H3,(H,25,29) AIWWQMSKUJBXID-UHFFFAOYSA-N 369313 4-[6-(1-methylpyrazol-4-yl)thieno[3,2- d]pyrimidin-4-yl]-N-phenyl-piperazine-1- carboxamide::US10227357, Compound P-0627 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369313 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369313&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 73388632 402366107 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729637 Cc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)-c1ncnc2cc(sc12)-c1cnn(C)c1 InChI=1S/C23H19N5O2S2/c1-15-3-9-19(10-4-15)32(29,30)27-18-7-5-16(6-8-18)22-23-20(24-14-25-22)11-21(31-23)17-12-26-28(2)13-17/h3-14,27H,1-2H3 PAVHSHXPUBOCKV-UHFFFAOYSA-N 369314 4-methyl-N-[4-[6-(1-methylpyrazol-4- yl)thieno[3,2-d]pyrimidin-4- yl]phenyl]benzenesulfonamide::US10227357, Compound P-0628 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369314 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369314&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 73389713 402366108 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729638 Brc1cc2ncnc(N3CCN(CC3)C(=O)NCc3ccccc3)c2s1 InChI=1S/C18H18BrN5OS/c19-15-10-14-16(26-15)17(22-12-21-14)23-6-8-24(9-7-23)18(25)20-11-13-4-2-1-3-5-13/h1-5,10,12H,6-9,11H2,(H,20,25) NTQUGJARNYKBIS-UHFFFAOYSA-N 369315 N-benzyl-4-(6-bromothieno[3,2- d]pyrimidin-4-yl)piperazine-1- carboxamide::US10227357, Compound P-0629 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369315 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369315&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 73388459 402366109 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729639 CCS(=O)Nc1ccc(cc1)-c1ncnc2cc(sc12)-c1ccc(F)cc1 InChI=1S/C20H16FN3OS2/c1-2-27(25)24-16-9-5-14(6-10-16)19-20-17(22-12-23-19)11-18(26-20)13-3-7-15(21)8-4-13/h3-12,24H,2H2,1H3 ZJMLXXDQGAIBHD-UHFFFAOYSA-N 369316 N-[4-[6-(4-fluorophenyl)thieno[3,2- d]pyrimidin-4- yl]phenyl]ethanesulfonamide::US10227357, Compound P-0630 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369316 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369316&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90135155 402366110 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729640 CC(=O)Nc1ccc(cc1)-c1ncnc2cc(sc12)-c1ccc(F)cc1 InChI=1S/C20H14FN3OS/c1-12(25)24-16-8-4-14(5-9-16)19-20-17(22-11-23-19)10-18(26-20)13-2-6-15(21)7-3-13/h2-11H,1H3,(H,24,25) INWJCBBMDVIOQR-UHFFFAOYSA-N 369317 N-[4-[6-(4-fluorophenyl)thieno[3,2- d]pyrimidin-4-yl]phenyl]acetamide::US10227357, Compound P-0632 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369317 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369317&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 73388462 402366111 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729641 Nc1ccc(cc1)-c1ncnc2cc(sc12)-c1ccc(F)cc1 InChI=1S/C18H12FN3S/c19-13-5-1-11(2-6-13)16-9-15-18(23-16)17(22-10-21-15)12-3-7-14(20)8-4-12/h1-10H,20H2 FLVZWCRABVYPHW-UHFFFAOYSA-N 369318 4-[6-(4-fluorophenyl)thieno[3,2- d]pyrimidin-4-yl]aniline::US10227357, Compound P-0634 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369318 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369318&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 73388464 402366112 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729642 Fc1ccc(cc1)-c1cc2ncnc(-c3ccc(cc3)S(=O)(=O)NCc3ccccc3)c2s1 InChI=1S/C25H18FN3O2S2/c26-20-10-6-18(7-11-20)23-14-22-25(32-23)24(28-16-27-22)19-8-12-21(13-9-19)33(30,31)29-15-17-4-2-1-3-5-17/h1-14,16,29H,15H2 SNUQYNAKEIFPEF-UHFFFAOYSA-N 369319 N-benzyl-4-[6-(4-fluorophenyl)thieno[3,2- d]pyrimidin-4-yl]benzenesulfonamide::US10227357, Compound P-0635 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369319 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369319&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 73388549 402366113 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729643 Cc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)-c1ncnc2cc(sc12)-c1ccc(F)cc1 InChI=1S/C25H18FN3O2S2/c1-16-2-12-21(13-3-16)33(30,31)29-20-10-6-18(7-11-20)24-25-22(27-15-28-24)14-23(32-25)17-4-8-19(26)9-5-17/h2-15,29H,1H3 CRAVPZBXIWGWAK-UHFFFAOYSA-N 369320 N-[4-[6-(4-fluorophenyl)thieno[3,2- d]pyrimidin-4-yl]phenyl]-4-methyl- benzenesulfonamide::US10227357, Compound P-0636 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369320 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369320&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 73389709 402366114 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729644 CC(C)(C)c1cc2ncnc(N3CCN(CC3)C(=O)NCc3ccc(F)cc3)c2s1 InChI=1S/C22H26FN5OS/c1-22(2,3)18-12-17-19(30-18)20(26-14-25-17)27-8-10-28(11-9-27)21(29)24-13-15-4-6-16(23)7-5-15/h4-7,12,14H,8-11,13H2,1-3H3,(H,24,29) VEHRJBAACZBXTL-UHFFFAOYSA-N 369321 4-(6-tert-butylthieno[3,2-d]pyrimidin-4- yl)-N-[(4-fluorophenyl)methyl]piperazine- 1-carboxamide::US10227357, Compound P-0637 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369321 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369321&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 73389134 402366115 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729645 Fc1ccc(CNC(=O)N2CCN(CC2)c2ncnc3ccsc23)cc1 InChI=1S/C18H18FN5OS/c19-14-3-1-13(2-4-14)11-20-18(25)24-8-6-23(7-9-24)17-16-15(5-10-26-16)21-12-22-17/h1-5,10,12H,6-9,11H2,(H,20,25) MODOQRQZTUKAKQ-UHFFFAOYSA-N 369322 N-[(4-fluorophenyl)methyl]-4-thieno[3,2- d]pyrimidin-4-yl-piperazine-1- carboxamide::US10227357, Compound P-0638 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369322 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369322&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 73389133 402366116 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729646 Fc1ccc(CNC(=O)N2CCN(CC2)c2ncnc3ccsc23)cc1 InChI=1S/C18H18FN5OS/c19-14-3-1-13(2-4-14)11-20-18(25)24-8-6-23(7-9-24)17-16-15(5-10-26-16)21-12-22-17/h1-5,10,12H,6-9,11H2,(H,20,25) MODOQRQZTUKAKQ-UHFFFAOYSA-N 369322 N-[(4-fluorophenyl)methyl]-4-thieno[3,2- d]pyrimidin-4-yl-piperazine-1- carboxamide::US10227357, Compound P-0638 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369322 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369322&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 73389133 402366116 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729647 CC(C)(C)c1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(F)cc3)c2s1 InChI=1S/C21H24FN5OS/c1-21(2,3)17-12-16-18(29-17)19(24-13-23-16)26-8-10-27(11-9-26)20(28)25-15-6-4-14(22)5-7-15/h4-7,12-13H,8-11H2,1-3H3,(H,25,28) WRALHONEMJDZRY-UHFFFAOYSA-N 369323 4-(6-tert-butylthieno[3,2-d]pyrimidin-4- yl)-N-(4-fluorophenyl)piperazine-1- carboxamide::US10227357, Compound P-0639 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369323 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369323&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 73389135 402366117 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729648 Fc1ccc(NC(=O)N2CCN(CC2)c2ncnc3ccsc23)cc1 InChI=1S/C17H16FN5OS/c18-12-1-3-13(4-2-12)21-17(24)23-8-6-22(7-9-23)16-15-14(5-10-25-15)19-11-20-16/h1-5,10-11H,6-9H2,(H,21,24) LVZULZGPNOLDHN-UHFFFAOYSA-N 369324 N-(4-fluorophenyl)-4-thieno[3,2- d]pyrimidin-4-yl-piperazine-1- carboxamide::US10227357, Compound P-0640 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369324 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369324&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 73389710 402366118 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729649 C[C@H](NC(=O)N1CCN(CC1(C)C)c1ncnc2[nH]c(C)cc12)c1cccc(Cl)c1 369325 N-[(1S)-1-(3-chlorophenyl)ethyl]-2,2- dimethyl-4-(6-methyl-7H-pyrrolo[2,3- d]pyrimidin-4-yl)piperazine-1-carboxamide::US10227357, Compound P-0641 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369325 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369325&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114844 402366119 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729650 C[C@H](NC(=O)N1CCN(CC1(C)C)c1ncnc2[nH]c(C)cc12)c1cccc(Cl)c1 369325 N-[(1S)-1-(3-chlorophenyl)ethyl]-2,2- dimethyl-4-(6-methyl-7H-pyrrolo[2,3- d]pyrimidin-4-yl)piperazine-1-carboxamide::US10227357, Compound P-0641 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369325 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369325&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114844 402366119 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729651 C[C@H](NC(=O)N1CCN(CC1(C)C)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1)c1ccc(F)cc1 369326 N-[(1S)-1-(4-fluorophenyl)ethyl]-4-[6-(4- fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]-2,2-dimethyl-piperazine-1-carboxamide::US10227357, Compound P-0642 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369326 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369326&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115231 402366120 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729652 C[C@H](NC(=O)N1CCN(CC1(C)C)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1)c1ccc(F)cc1 369326 N-[(1S)-1-(4-fluorophenyl)ethyl]-4-[6-(4- fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]-2,2-dimethyl-piperazine-1-carboxamide::US10227357, Compound P-0642 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369326 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369326&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115231 402366120 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729653 COc1cc(ccn1)-c1cc2c(ncnc2[nH]1)N1CCN(C(=O)N[C@@H](C)c2ccc(F)cc2)C(C)(C)C1 369327 N-[(1S)-1-(4-fluorophenypethyl]-4-[6-(2- methoxy-4-pyridyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-2,2-dimethyl-piperazine-1- carboxamide::US10227357, Compound P-0643 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369327 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369327&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90137127 402366121 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729654 COc1cc(ccn1)-c1cc2c(ncnc2[nH]1)N1CCN(C(=O)N[C@@H](C)c2ccc(F)cc2)C(C)(C)C1 369327 N-[(1S)-1-(4-fluorophenypethyl]-4-[6-(2- methoxy-4-pyridyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-2,2-dimethyl-piperazine-1- carboxamide::US10227357, Compound P-0643 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369327 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369327&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90137127 402366121 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729655 C[C@H](NC(=O)N1CCN(CC1(C)C)c1ncnc2[nH]c(C)cc12)c1ccc(F)cc1 369328 N-[(1S)-1-(4-fluorophenyl)ethyl]-2,2- dimethyl-4-(6-methyl-7H-pyrrolo[2,3- d]pyrimidin-4-yl)piperazine-1-carboxamide::US10227357, Compound P-0644 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369328 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369328&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114021 402366122 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729656 C[C@H](NC(=O)N1CCN(CC1(C)C)c1ncnc2[nH]c(C)cc12)c1ccc(F)cc1 369328 N-[(1S)-1-(4-fluorophenyl)ethyl]-2,2- dimethyl-4-(6-methyl-7H-pyrrolo[2,3- d]pyrimidin-4-yl)piperazine-1-carboxamide::US10227357, Compound P-0644 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369328 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369328&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114021 402366122 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729657 C[C@H](NC(=O)N1CCN(CC1(C)C)c1ncnc2[nH]c(C)cc12)c1cccc(OC(F)F)c1 369329 N-[(1S)-1-[3-(difluoromethoxy)phenyl]ethyl]- 2,2-dimethyl-4-(6-methyl-7H-pyrrolo[2,3- d]pyrimidin-4-yl)piperazine-1-carboxamide::US10227357, Compound P-0645 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369329 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369329&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114592 402366123 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729658 C[C@H](NC(=O)N1CCN(CC1(C)C)c1ncnc2[nH]c(C)cc12)c1cccc(OC(F)F)c1 369329 N-[(1S)-1-[3-(difluoromethoxy)phenyl]ethyl]- 2,2-dimethyl-4-(6-methyl-7H-pyrrolo[2,3- d]pyrimidin-4-yl)piperazine-1-carboxamide::US10227357, Compound P-0645 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369329 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369329&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114592 402366123 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729659 C[C@H](NC(=O)N1CCN(C[C@H]1C)c1ncnc2[nH]c(C)cc12)c1ccc(F)cc1 369330 (2R)-N-[(1S)-1-(4-fluorophenyl)ethyl]-2- methyl-4-(6-methyl-7H-pyrrolo[2,3- d]pyrimidin-4-yl)piperazine-1-carboxamide::US10227357, Compound P-0646 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369330 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369330&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114427 402366124 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729660 C[C@H](NC(=O)N1CCN(C[C@H]1C)c1ncnc2[nH]c(C)cc12)c1ccc(F)cc1 369330 (2R)-N-[(1S)-1-(4-fluorophenyl)ethyl]-2- methyl-4-(6-methyl-7H-pyrrolo[2,3- d]pyrimidin-4-yl)piperazine-1-carboxamide::US10227357, Compound P-0646 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369330 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369330&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114427 402366124 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729661 C[C@H](NC(=O)N1CCN(C[C@H]1C)c1ncnc2[nH]c(C)cc12)c1cccc(Cl)c1 369331 (2R)-N-[(1S)-1-(3-chlorophenyl)ethyl]-2- methyl-4-(6-methyl-7H-pyrrolo[2,3- d]pyrimidin-4-yl)piperazine-1-carboxamide::US10227357, Compound P-0647 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369331 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369331&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114479 402366125 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729662 C[C@H](NC(=O)N1CCN(C[C@H]1C)c1ncnc2[nH]c(C)cc12)c1cccc(Cl)c1 369331 (2R)-N-[(1S)-1-(3-chlorophenyl)ethyl]-2- methyl-4-(6-methyl-7H-pyrrolo[2,3- d]pyrimidin-4-yl)piperazine-1-carboxamide::US10227357, Compound P-0647 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369331 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369331&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114479 402366125 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729663 C[C@H](NC(=O)N1CCN(C[C@H]1C)c1ncnc2[nH]c(C)cc12)c1cccc(OC(F)F)c1 369332 (2R)-N-[(1S)-1-[3- (difluoromethoxy)phenyl]ethyl]-2-methyl-4- (6-methyl-7H-pyrrolo[2,3-d]pyrimidin-4- yl)piperazine-1-carboxamide::US10227357, Compound P-0648 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369332 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369332&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115351 402366126 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729664 C[C@H](NC(=O)N1CCN(C[C@H]1C)c1ncnc2[nH]c(C)cc12)c1cccc(OC(F)F)c1 369332 (2R)-N-[(1S)-1-[3- (difluoromethoxy)phenyl]ethyl]-2-methyl-4- (6-methyl-7H-pyrrolo[2,3-d]pyrimidin-4- yl)piperazine-1-carboxamide::US10227357, Compound P-0648 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369332 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369332&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115351 402366126 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729665 COc1cc(ccc1Cl)[C@H](C)NC(=O)N1CCN(C[C@H]1C)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 369333 (2R)-N-[(1S)-1-(4-chloro-3-methoxy- phenyl)ethyl]-4-[6-(4-fluorophenyl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]-2-methyl- piperazine-1-carboxamide::US10227357, Compound P-0649 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369333 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369333&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114442 402366127 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729666 COc1cc(ccc1Cl)[C@H](C)NC(=O)N1CCN(C[C@H]1C)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 369333 (2R)-N-[(1S)-1-(4-chloro-3-methoxy- phenyl)ethyl]-4-[6-(4-fluorophenyl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]-2-methyl- piperazine-1-carboxamide::US10227357, Compound P-0649 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369333 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369333&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114442 402366127 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729667 COc1cc(ccn1)-c1cc2c(ncnc2[nH]1)N1CCN(C(=O)N[C@@H](C)c2cccc(Cl)c2)C(C)(C)C1 369334 N-[(1S)-1-(3-chlorophenyl)ethyl]-4-[6-(2- methoxy-4-pyridyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-2,2-dimethyl-piperazine-1- carboxamide::US10227357, Compound P-0650 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369334 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369334&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 89993926 402366128 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729668 COc1cc(ccn1)-c1cc2c(ncnc2[nH]1)N1CCN(C(=O)N[C@@H](C)c2cccc(Cl)c2)C(C)(C)C1 369334 N-[(1S)-1-(3-chlorophenyl)ethyl]-4-[6-(2- methoxy-4-pyridyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-2,2-dimethyl-piperazine-1- carboxamide::US10227357, Compound P-0650 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369334 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369334&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 89993926 402366128 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729669 CCCc1ccc(cc1)S(=O)(=O)NC1CCC(=CC1)c1ncnc2[nH]c(C)cc12 369335 N-[4-(6-methyl-7H-pyrrolo[2,3- d]pyrimidin-4-yl)cyclohex-3-en-1-yl]-4- propyl-benzenesulfonamide::US10227357, Compound P-0651 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369335 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369335&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115150 402366129 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729670 CC(C)Oc1ccc(cc1)S(=O)(=O)NC1CCC(=CC1)c1ncnc2[nH]c(C)cc12 369336 4-isopropoxy-N-[4-(6-methyl-7H- pyrrolo[2,3-d]pyrimidin-4-yl)cyclohex-3- en-1-yl]benzenesulfonamide::US10227357, Compound P-0652 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369336 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369336&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114982 402366130 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729671 Cc1cc2c(ncnc2[nH]1)C1=CCC(CC1)NS(=O)(=O)c1ccc(OC(F)F)cc1 369337 4-(difluoromethoxy)-N-[4-(6-methyl-7H- pyrrolo[2,3-d]pyrimidin-4-yl)cyclohex-3- en-1-yl]benzenesulfonamide::US10227357, Compound P-0653 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369337 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369337&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115060 402366131 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729672 COc1cc(ccn1)-c1cc2c(ncnc2[nH]1)C1=CCC(CC1)NS(=O)(=O)c1ccc(OC(F)(F)F)cc1 369338 N-[4-[6-(2-methoxy-4-pyridyl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]cyclohex-3- en-1-yl]-4- (trifluoromethoxy)benzenesulfonamide::US10227357, Compound P-0654 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369338 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369338&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114903 402366132 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729673 COc1cc(ccn1)-c1cc2c(ncnc2[nH]1)C1=CCC(CC1)NS(=O)(=O)c1ccc(OC(F)(F)F)cc1 369338 N-[4-[6-(2-methoxy-4-pyridyl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]cyclohex-3- en-1-yl]-4- (trifluoromethoxy)benzenesulfonamide::US10227357, Compound P-0654 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369338 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369338&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114903 402366132 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729674 FC(F)Oc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)-c1ncnc2[nH]c(Cl)cc12 InChI=1S/C19H13ClF2N4O3S/c20-16-9-15-17(23-10-24-18(15)25-16)11-1-3-12(4-2-11)26-30(27,28)14-7-5-13(6-8-14)29-19(21)22/h1-10,19,26H,(H,23,24,25) SCEDYILIGCUIBR-UHFFFAOYSA-N 369339 N-[4-(6-chloro-7H-pyrrolo[2,3- d]pyrimidin-4-yl)phenyl]-4- (difluoromethoxy)benzenesulfonamide::US10227357, Compound P-0655 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369339 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369339&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 86718042 402366133 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729675 FC(F)Oc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)-c1ncnc2[nH]c(Cl)cc12 InChI=1S/C19H13ClF2N4O3S/c20-16-9-15-17(23-10-24-18(15)25-16)11-1-3-12(4-2-11)26-30(27,28)14-7-5-13(6-8-14)29-19(21)22/h1-10,19,26H,(H,23,24,25) SCEDYILIGCUIBR-UHFFFAOYSA-N 369339 N-[4-(6-chloro-7H-pyrrolo[2,3- d]pyrimidin-4-yl)phenyl]-4- (difluoromethoxy)benzenesulfonamide::US10227357, Compound P-0655 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369339 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369339&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 86718042 402366133 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729676 Cc1cc2c(ncnc2[nH]1)N1CCC(CC1)NS(=O)(=O)c1ccc(OC(F)F)cc1 InChI=1S/C19H21F2N5O3S/c1-12-10-16-17(24-12)22-11-23-18(16)26-8-6-13(7-9-26)25-30(27,28)15-4-2-14(3-5-15)29-19(20)21/h2-5,10-11,13,19,25H,6-9H2,1H3,(H,22,23,24) DNIHCLOAKJRQPV-UHFFFAOYSA-N 369340 4-(difluoromethoxy)-N-[1-(6-methyl- 7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4- piperidyl]benzenesulfonamide::US10227357, Compound P-0656 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369340 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369340&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114724 402366134 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729677 CC(C)c1ccc(cc1)S(=O)(=O)NC1CCN(CC1)c1ncnc2[nH]c(C)cc12 InChI=1S/C21H27N5O2S/c1-14(2)16-4-6-18(7-5-16)29(27,28)25-17-8-10-26(11-9-17)21-19-12-15(3)24-20(19)22-13-23-21/h4-7,12-14,17,25H,8-11H2,1-3H3,(H,22,23,24) SBAHUHNZIUFUKG-UHFFFAOYSA-N 369341 4-isopropyl-N-[1-(6-methyl-7H- pyrrolo[2,3-d]pyrimidin-4-yl)-4- piperidyl]benzenesulfonamide::US10227357, Compound P-0657 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369341 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369341&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114539 402366135 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729678 CCCc1ccc(cc1)S(=O)(=O)NC1CCN(CC1)c1ncnc2[nH]c(C)cc12 InChI=1S/C21H27N5O2S/c1-3-4-16-5-7-18(8-6-16)29(27,28)25-17-9-11-26(12-10-17)21-19-13-15(2)24-20(19)22-14-23-21/h5-8,13-14,17,25H,3-4,9-12H2,1-2H3,(H,22,23,24) CEAYMGKJURPQNY-UHFFFAOYSA-N 369342 N-[1-(6-methyl-7H-pyrrolo[2,3- d]pyrimidin-4-yl)-4-piperidyl]-4-propyl- benzenesulfonamide::US10227357, Compound P-0658 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369342 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369342&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114642 402366136 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729679 Cc1nn(C)cc1-c1cc2c(ncnc2[nH]1)N1CCC(CC1)NS(=O)(=O)c1ccc(C)cc1 InChI=1S/C23H27N7O2S/c1-15-4-6-18(7-5-15)33(31,32)28-17-8-10-30(11-9-17)23-19-12-21(26-22(19)24-14-25-23)20-13-29(3)27-16(20)2/h4-7,12-14,17,28H,8-11H2,1-3H3,(H,24,25,26) ULLMBBXJQUJFPA-UHFFFAOYSA-N 369343 N-[1-[6-(1,3-dimethylpyrazol-4-yl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]-4- piperidyl]-4-methyl- benzenesulfonamide::US10227357, Compound P-0659 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369343 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369343&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114218 402366137 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729680 COc1cc(ccn1)-c1cc2c(ncnc2[nH]1)N1CCC(CC1)NS(=O)(=O)c1ccc(C)cc1 InChI=1S/C24H26N6O3S/c1-16-3-5-19(6-4-16)34(31,32)29-18-8-11-30(12-9-18)24-20-14-21(28-23(20)26-15-27-24)17-7-10-25-22(13-17)33-2/h3-7,10,13-15,18,29H,8-9,11-12H2,1-2H3,(H,26,27,28) KVOUKXUIRUUYJR-UHFFFAOYSA-N 369344 N-[1-[6-(2-methoxy-4-pyridyl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]-4- piperidyl]-4-methyl- benzenesulfonamide::US10227357, Compound P-0660 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369344 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369344&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114403 402366138 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729681 Cc1csc(c1)-c1cc2c(ncnc2[nH]1)N1CCC(CC1)NS(=O)(=O)c1ccc(OC(F)(F)F)cc1 InChI=1S/C23H22F3N5O3S2/c1-14-10-20(35-12-14)19-11-18-21(29-19)27-13-28-22(18)31-8-6-15(7-9-31)30-36(32,33)17-4-2-16(3-5-17)34-23(24,25)26/h2-5,10-13,15,30H,6-9H2,1H3,(H,27,28,29) TUOBNFJLHQVUEH-UHFFFAOYSA-N 369345 N-[1-[6-(4-methyl-2-thienyl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]-4- piperidyl]-4- (trifluoromethoxy)benzenesulfonamide::US10227357, Compound P-0661 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369345 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369345&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115435 402366139 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729682 CC1(C)CC(=CC(C)(C)N1)c1cc2c(ncnc2[nH]1)N1CCC(CC1)NS(=O)(=O)c1ccc(OC(F)(F)F)cc1 InChI=1S/C27H33F3N6O3S/c1-25(2)14-17(15-26(3,4)35-25)22-13-21-23(33-22)31-16-32-24(21)36-11-9-18(10-12-36)34-40(37,38)20-7-5-19(6-8-20)39-27(28,29)30/h5-8,13-14,16,18,34-35H,9-12,15H2,1-4H3,(H,31,32,33) RJSHSZPMGOBBRL-UHFFFAOYSA-N 369346 N-[1-[6-(2,2,6,6-tetramethyl-1,3- dihydropyridin-4-yl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-4-piperidyl]-4- (trifluoromethoxy)benzenesulfonamide::US10227357, Compound P-0662 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369346 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369346&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114369 402366140 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729683 CC1(C)CC(=CC(C)(C)N1)c1cc2c(ncnc2[nH]1)N1CCC(CC1)NS(=O)(=O)c1ccc(OC(F)(F)F)cc1 InChI=1S/C27H33F3N6O3S/c1-25(2)14-17(15-26(3,4)35-25)22-13-21-23(33-22)31-16-32-24(21)36-11-9-18(10-12-36)34-40(37,38)20-7-5-19(6-8-20)39-27(28,29)30/h5-8,13-14,16,18,34-35H,9-12,15H2,1-4H3,(H,31,32,33) RJSHSZPMGOBBRL-UHFFFAOYSA-N 369346 N-[1-[6-(2,2,6,6-tetramethyl-1,3- dihydropyridin-4-yl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-4-piperidyl]-4- (trifluoromethoxy)benzenesulfonamide::US10227357, Compound P-0662 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369346 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369346&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114369 402366140 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729684 CC1(C)CC(=CC(C)(C)O1)c1cc2c(ncnc2[nH]1)N1CCC(CC1)NS(=O)(=O)c1ccc(OC(F)(F)F)cc1 InChI=1S/C27H32F3N5O4S/c1-25(2)14-17(15-26(3,4)39-25)22-13-21-23(33-22)31-16-32-24(21)35-11-9-18(10-12-35)34-40(36,37)20-7-5-19(6-8-20)38-27(28,29)30/h5-8,13-14,16,18,34H,9-12,15H2,1-4H3,(H,31,32,33) KZFLGDVDRMPXHQ-UHFFFAOYSA-N 369347 N-[1-[6-(2,2,6,6-tetramethyl-3H-pyran- 4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]- 4-piperidyl]-4- (trifluoromethoxy)benzenesulfonamide::US10227357, Compound P-0663 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369347 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369347&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114802 402366141 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729685 Cc1nc(C)c(s1)-c1cc2c(ncnc2[nH]1)N1CCC(CC1)NS(=O)(=O)c1ccc(OC(F)(F)F)cc1 InChI=1S/C23H23F3N6O3S2/c1-13-20(36-14(2)29-13)19-11-18-21(30-19)27-12-28-22(18)32-9-7-15(8-10-32)31-37(33,34)17-5-3-16(4-6-17)35-23(24,25)26/h3-6,11-12,15,31H,7-10H2,1-2H3,(H,27,28,30) YACKSJVPNYSGIG-UHFFFAOYSA-N 369348 N-[1-[6-(2,4-dimethylthiazol-5-yl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]-4- piperidyl]-4- (trifluoromethoxy)benzenesulfonamide::US10227357, Compound P-0664 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369348 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369348&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114004 402366142 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729686 Cc1nc(C)c(s1)-c1cc2c(ncnc2[nH]1)N1CCC(CC1)NS(=O)(=O)c1ccc(OC(F)(F)F)cc1 InChI=1S/C23H23F3N6O3S2/c1-13-20(36-14(2)29-13)19-11-18-21(30-19)27-12-28-22(18)32-9-7-15(8-10-32)31-37(33,34)17-5-3-16(4-6-17)35-23(24,25)26/h3-6,11-12,15,31H,7-10H2,1-2H3,(H,27,28,30) YACKSJVPNYSGIG-UHFFFAOYSA-N 369348 N-[1-[6-(2,4-dimethylthiazol-5-yl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]-4- piperidyl]-4- (trifluoromethoxy)benzenesulfonamide::US10227357, Compound P-0664 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369348 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369348&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114004 402366142 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729687 CCc1ccc(s1)S(=O)(=O)NC1CCN(CC1)c1ncnc2[nH]c(cc12)-c1cnn(C)c1 InChI=1S/C21H25N7O2S2/c1-3-16-4-5-19(31-16)32(29,30)26-15-6-8-28(9-7-15)21-17-10-18(14-11-24-27(2)12-14)25-20(17)22-13-23-21/h4-5,10-13,15,26H,3,6-9H2,1-2H3,(H,22,23,25) PCNXFOUZRCOZFZ-UHFFFAOYSA-N 369349 5-ethyl-N-[1-[6-(1-methylpyrazol-4-yl)- 7H-pyrrolo[2,3-d]pyrimidin-4-yl]-4- piperidyl]thiophene-2-sulfonamide::US10227357, Compound P-0665 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369349 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369349&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90001370 402366143 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729688 CCc1ccc(s1)S(=O)(=O)NC1CCN(CC1)c1ncnc2[nH]c(cc12)-c1cnn(C)c1 InChI=1S/C21H25N7O2S2/c1-3-16-4-5-19(31-16)32(29,30)26-15-6-8-28(9-7-15)21-17-10-18(14-11-24-27(2)12-14)25-20(17)22-13-23-21/h4-5,10-13,15,26H,3,6-9H2,1-2H3,(H,22,23,25) PCNXFOUZRCOZFZ-UHFFFAOYSA-N 369349 5-ethyl-N-[1-[6-(1-methylpyrazol-4-yl)- 7H-pyrrolo[2,3-d]pyrimidin-4-yl]-4- piperidyl]thiophene-2-sulfonamide::US10227357, Compound P-0665 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369349 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369349&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90001370 402366143 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729689 COc1cc(ccn1)-c1cc2c(ncnc2[nH]1)N1CCC(CC1)NS(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C23H23ClN6O3S/c1-33-21-12-15(6-9-25-21)20-13-19-22(28-20)26-14-27-23(19)30-10-7-17(8-11-30)29-34(31,32)18-4-2-16(24)3-5-18/h2-6,9,12-14,17,29H,7-8,10-11H2,1H3,(H,26,27,28) IWOGWHZWRGMSNS-UHFFFAOYSA-N 369350 4-chloro-N-[1-[6-(2-methoxy-4- pyridyl)-7H-pyrrolo[2,3-d]pyrimidin-4- yl]-4-piperidyl]benzenesulfonamide::US10227357, Compound P-0666 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369350 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369350&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90002492 402366144 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729690 Cc1nn(C)cc1-c1cc2c(ncnc2[nH]1)N1CCC(CC1)NS(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C22H24ClN7O2S/c1-14-19(12-29(2)27-14)20-11-18-21(26-20)24-13-25-22(18)30-9-7-16(8-10-30)28-33(31,32)17-5-3-15(23)4-6-17/h3-6,11-13,16,28H,7-10H2,1-2H3,(H,24,25,26) ZTBFFRNCHRMIBF-UHFFFAOYSA-N 369351 4-chloro-N-[1-[6-(1,3-dimethylpyrazol- 4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]- 4-piperidyl]benzenesulfonamide::US10227357, Compound P-0667 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369351 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369351&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115098 402366145 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729691 Cc1nn(C)cc1-c1cc2c(ncnc2[nH]1)N1CCC(CC1)NS(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C22H24ClN7O2S/c1-14-19(12-29(2)27-14)20-11-18-21(26-20)24-13-25-22(18)30-9-7-16(8-10-30)28-33(31,32)17-5-3-15(23)4-6-17/h3-6,11-13,16,28H,7-10H2,1-2H3,(H,24,25,26) ZTBFFRNCHRMIBF-UHFFFAOYSA-N 369351 4-chloro-N-[1-[6-(1,3-dimethylpyrazol- 4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]- 4-piperidyl]benzenesulfonamide::US10227357, Compound P-0667 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369351 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369351&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115098 402366145 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729692 Cc1nn(C)cc1-c1cc2c(ncnc2[nH]1)N1CCC(CC1)NS(=O)(=O)c1ccc(OC(F)(F)F)cc1 InChI=1S/C23H24F3N7O3S/c1-14-19(12-32(2)30-14)20-11-18-21(29-20)27-13-28-22(18)33-9-7-15(8-10-33)31-37(34,35)17-5-3-16(4-6-17)36-23(24,25)26/h3-6,11-13,15,31H,7-10H2,1-2H3,(H,27,28,29) SVCFFZZVJFBKRK-UHFFFAOYSA-N 369352 N-[1-[6-(1,3-dimethylpyrazol-4-yl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]-4- piperidyl]-4- (trifluoromethoxy)benzenesulfonamide::US10227357, Compound P-0668 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369352 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369352&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114392 402366146 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729693 Cc1nn(C)cc1-c1cc2c(ncnc2[nH]1)N1CCC(CC1)NS(=O)(=O)c1ccc(OC(F)(F)F)cc1 InChI=1S/C23H24F3N7O3S/c1-14-19(12-32(2)30-14)20-11-18-21(29-20)27-13-28-22(18)33-9-7-15(8-10-33)31-37(34,35)17-5-3-16(4-6-17)36-23(24,25)26/h3-6,11-13,15,31H,7-10H2,1-2H3,(H,27,28,29) SVCFFZZVJFBKRK-UHFFFAOYSA-N 369352 N-[1-[6-(1,3-dimethylpyrazol-4-yl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]-4- piperidyl]-4- (trifluoromethoxy)benzenesulfonamide::US10227357, Compound P-0668 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369352 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369352&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114392 402366146 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729694 FC(F)(F)Oc1ccc(cc1)S(=O)(=O)NC1CCN(CC1)c1ncnc2[nH]c(cc12)C1=CCCC1 InChI=1S/C23H24F3N5O3S/c24-23(25,26)34-17-5-7-18(8-6-17)35(32,33)30-16-9-11-31(12-10-16)22-19-13-20(15-3-1-2-4-15)29-21(19)27-14-28-22/h3,5-8,13-14,16,30H,1-2,4,9-12H2,(H,27,28,29) DPQFRYGYVOCZAS-UHFFFAOYSA-N 369353 N-[1-[6-(cyclopenten-1-yl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]-4- piperidyl]-4- (trifluoromethoxy)benzenesulfonamide::US10227357, Compound P-0669 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369353 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369353&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114072 402366147 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729695 FC(F)(F)Oc1ccc(cc1)S(=O)(=O)NC1CCN(CC1)c1ncnc2[nH]c(cc12)C1=CCCC1 InChI=1S/C23H24F3N5O3S/c24-23(25,26)34-17-5-7-18(8-6-17)35(32,33)30-16-9-11-31(12-10-16)22-19-13-20(15-3-1-2-4-15)29-21(19)27-14-28-22/h3,5-8,13-14,16,30H,1-2,4,9-12H2,(H,27,28,29) DPQFRYGYVOCZAS-UHFFFAOYSA-N 369353 N-[1-[6-(cyclopenten-1-yl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]-4- piperidyl]-4- (trifluoromethoxy)benzenesulfonamide::US10227357, Compound P-0669 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369353 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369353&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114072 402366147 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729696 FC(F)(F)Oc1ccc(cc1)S(=O)(=O)NC1CCN(CC1)c1ncnc2[nH]c(cc12)-c1cc(Cl)cs1 InChI=1S/C22H19ClF3N5O3S2/c23-13-9-19(35-11-13)18-10-17-20(29-18)27-12-28-21(17)31-7-5-14(6-8-31)30-36(32,33)16-3-1-15(2-4-16)34-22(24,25)26/h1-4,9-12,14,30H,5-8H2,(H,27,28,29) AWYANESNMMTKNS-UHFFFAOYSA-N 369354 N-[1-[6-(4-chloro-2-thienyl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]-4- piperidyl]-4- (trifluoromethoxy)benzenesulfonamide::US10227357, Compound P-0670 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369354 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369354&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114948 402366148 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729697 CC1CN(CCC1NS(=O)(=O)c1ccc(C)cc1)c1ncnc2[nH]c(cc12)-c1cnn(C)c1 369355 4-methyl-N-[3-methyl-1-[6-(1- methylpyrazol-4-yl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-4- piperidyl]benzenesulfonamide::US10227357, Compound P-0672 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369355 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369355&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114544 402366149 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729698 CC1CN(CCC1NS(=O)(=O)c1ccc(C)cc1)c1ncnc2[nH]c(cc12)-c1cnn(C)c1 369355 4-methyl-N-[3-methyl-1-[6-(1- methylpyrazol-4-yl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-4- piperidyl]benzenesulfonamide::US10227357, Compound P-0672 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369355 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369355&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114544 402366149 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729699 CN(C)c1ncc(s1)-c1cc2c(ncnc2[nH]1)N1CCC(CC1)NS(=O)(=O)c1ccc(OC(F)(F)F)cc1 InChI=1S/C23H24F3N7O3S2/c1-32(2)22-27-12-19(37-22)18-11-17-20(30-18)28-13-29-21(17)33-9-7-14(8-10-33)31-38(34,35)16-5-3-15(4-6-16)36-23(24,25)26/h3-6,11-14,31H,7-10H2,1-2H3,(H,28,29,30) DYKMVFAMLRWUSG-UHFFFAOYSA-N 369356 N-[1-[6-[2-(dimethylamino)thiazol-5- yl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-4- piperidyl]-4- (trifluoromethoxy)benzenesulfonamide::US10227357, Compound P-0673 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369356 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369356&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114282 402366150 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729700 CN(C)c1ncc(s1)-c1cc2c(ncnc2[nH]1)N1CCC(CC1)NS(=O)(=O)c1ccc(OC(F)(F)F)cc1 InChI=1S/C23H24F3N7O3S2/c1-32(2)22-27-12-19(37-22)18-11-17-20(30-18)28-13-29-21(17)33-9-7-14(8-10-33)31-38(34,35)16-5-3-15(4-6-16)36-23(24,25)26/h3-6,11-14,31H,7-10H2,1-2H3,(H,28,29,30) DYKMVFAMLRWUSG-UHFFFAOYSA-N 369356 N-[1-[6-[2-(dimethylamino)thiazol-5- yl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-4- piperidyl]-4- (trifluoromethoxy)benzenesulfonamide::US10227357, Compound P-0673 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369356 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369356&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114282 402366150 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729701 CCc1ccc(cc1)S(=O)(=O)NC1CCN(CC1)c1ncnc2[nH]c(C)cc12 InChI=1S/C20H25N5O2S/c1-3-15-4-6-17(7-5-15)28(26,27)24-16-8-10-25(11-9-16)20-18-12-14(2)23-19(18)21-13-22-20/h4-7,12-13,16,24H,3,8-11H2,1-2H3,(H,21,22,23) YJKXHMOIKYVZEB-UHFFFAOYSA-N 369357 4-ethyl-N-[1-(6-methyl-7H-pyrrolo[2,3- d]pyrimidin-4-yl)-4- piperidyl]benzenesulfonamide::US10227357, Compound P-0674 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369357 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369357&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114777 402366151 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729702 CCc1ccc(cc1)S(=O)(=O)NC1CCN(CC1)c1ncnc2[nH]c(C)cc12 InChI=1S/C20H25N5O2S/c1-3-15-4-6-17(7-5-15)28(26,27)24-16-8-10-25(11-9-16)20-18-12-14(2)23-19(18)21-13-22-20/h4-7,12-13,16,24H,3,8-11H2,1-2H3,(H,21,22,23) YJKXHMOIKYVZEB-UHFFFAOYSA-N 369357 4-ethyl-N-[1-(6-methyl-7H-pyrrolo[2,3- d]pyrimidin-4-yl)-4- piperidyl]benzenesulfonamide::US10227357, Compound P-0674 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369357 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369357&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114777 402366151 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729703 Cc1cc2c(ncnc2[nH]1)N1CCC(CC1)NS(=O)(=O)c1ccc(C)cc1 InChI=1S/C19H23N5O2S/c1-13-3-5-16(6-4-13)27(25,26)23-15-7-9-24(10-8-15)19-17-11-14(2)22-18(17)20-12-21-19/h3-6,11-12,15,23H,7-10H2,1-2H3,(H,20,21,22) CEDLKKXJHRSGBS-UHFFFAOYSA-N 369358 4-methyl-N-[1-(6-methyl-7H- pyrrolo[2,3-d]pyrimidin-4-yl)-4- piperidyl]benzenesulfonamide::US10227357, Compound P-0675 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369358 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369358&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114363 402366152 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729704 Cc1cc2c(ncnc2[nH]1)N1CCC(CC1)NS(=O)(=O)c1ccc(C)cc1 InChI=1S/C19H23N5O2S/c1-13-3-5-16(6-4-13)27(25,26)23-15-7-9-24(10-8-15)19-17-11-14(2)22-18(17)20-12-21-19/h3-6,11-12,15,23H,7-10H2,1-2H3,(H,20,21,22) CEDLKKXJHRSGBS-UHFFFAOYSA-N 369358 4-methyl-N-[1-(6-methyl-7H- pyrrolo[2,3-d]pyrimidin-4-yl)-4- piperidyl]benzenesulfonamide::US10227357, Compound P-0675 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369358 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369358&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114363 402366152 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729705 CCc1ccc(cc1)S(=O)(=O)NC1CCN(CC1)c1ncnc2[nH]c(cc12)-c1cnn(C)c1 InChI=1S/C23H27N7O2S/c1-3-16-4-6-19(7-5-16)33(31,32)28-18-8-10-30(11-9-18)23-20-12-21(17-13-26-29(2)14-17)27-22(20)24-15-25-23/h4-7,12-15,18,28H,3,8-11H2,1-2H3,(H,24,25,27) CTDNRRVSKCRXLI-UHFFFAOYSA-N 369359 4-ethyl-N-[1-[6-(1-methylpyrazol-4-yl)- 7H-pyrrolo[2,3-d]pyrimidin-4-yl]-4- piperidyl]benzenesulfonamide::US10227357, Compound P-0676 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369359 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369359&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 86718053 402366153 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729706 CCc1ccc(cc1)S(=O)(=O)NC1CCN(CC1)c1ncnc2[nH]c(cc12)-c1cnn(C)c1 InChI=1S/C23H27N7O2S/c1-3-16-4-6-19(7-5-16)33(31,32)28-18-8-10-30(11-9-18)23-20-12-21(17-13-26-29(2)14-17)27-22(20)24-15-25-23/h4-7,12-15,18,28H,3,8-11H2,1-2H3,(H,24,25,27) CTDNRRVSKCRXLI-UHFFFAOYSA-N 369359 4-ethyl-N-[1-[6-(1-methylpyrazol-4-yl)- 7H-pyrrolo[2,3-d]pyrimidin-4-yl]-4- piperidyl]benzenesulfonamide::US10227357, Compound P-0676 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369359 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369359&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 86718053 402366153 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729707 C[C@H](NC(=O)N1CCN(CC1(C)C)c1ncnc2ccsc12)c1cccc(Cl)c1 InChI=1S/C21H24ClN5OS/c1-14(15-5-4-6-16(22)11-15)25-20(28)27-9-8-26(12-21(27,2)3)19-18-17(7-10-29-18)23-13-24-19/h4-7,10-11,13-14H,8-9,12H2,1-3H3,(H,25,28)/t14-/m0/s1 PTZXWPWWGHRPCH-AWEZNQCLSA-N 369360 N-[(1S)-1-(3-chlorophenyl)ethyl]-2,2- dimethyl-4-thieno[3,2-d]pyrimidin-4-yl- piperazine-1-carboxamide::US10227357, Compound P-0677::US10227357, Compound P-0682 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369360 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369360&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 73389625 402366154 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729708 CC(C)(NC(=O)N1CCN(CC1(C)C)c1ncnc2cc(sc12)-c1ccc(F)cc1)c1ccccc1 InChI=1S/C28H30FN5OS/c1-27(2)17-33(14-15-34(27)26(35)32-28(3,4)20-8-6-5-7-9-20)25-24-22(30-18-31-25)16-23(36-24)19-10-12-21(29)13-11-19/h5-13,16,18H,14-15,17H2,1-4H3,(H,32,35) WVAYGUNTZLXVAR-UHFFFAOYSA-N 369361 4-[6-(4-fluorophenyl)thieno[3,2- d]pyrimidin-4-yl]-2,2-dimethyl-N-(1- methyl-1-phenyl-ethyl)piperazine-1- carboxamide::US10227357, Compound P-0678 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369361 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369361&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 73389711 402366155 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729709 CC(C)(NC(=O)N1CCC(=CC1)c1ncnc2cc(sc12)-c1ccc(F)cc1)c1ccccc1 InChI=1S/C27H25FN4OS/c1-27(2,20-6-4-3-5-7-20)31-26(33)32-14-12-19(13-15-32)24-25-22(29-17-30-24)16-23(34-25)18-8-10-21(28)11-9-18/h3-12,16-17H,13-15H2,1-2H3,(H,31,33) LAHLBBNHCRJZJQ-UHFFFAOYSA-N 369362 4-[6-(4-fluorophenyl)thieno[3,2- d]pyrimidin-4-yl]-N-(1-methyl-1-phenyl- ethyl)-3,6-dihydro-2H-pyridine-1- carboxamide::US10227357, Compound P-0679 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369362 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369362&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 73389712 402366156 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729710 CC(C)(NC(=O)N1CCC(=CC1)c1ncnc2cc(sc12)-c1ccc(F)cc1)c1ccccc1 InChI=1S/C27H25FN4OS/c1-27(2,20-6-4-3-5-7-20)31-26(33)32-14-12-19(13-15-32)24-25-22(29-17-30-24)16-23(34-25)18-8-10-21(28)11-9-18/h3-12,16-17H,13-15H2,1-2H3,(H,31,33) LAHLBBNHCRJZJQ-UHFFFAOYSA-N 369362 4-[6-(4-fluorophenyl)thieno[3,2- d]pyrimidin-4-yl]-N-(1-methyl-1-phenyl- ethyl)-3,6-dihydro-2H-pyridine-1- carboxamide::US10227357, Compound P-0679 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369362 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369362&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 73389712 402366156 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729711 COc1cccc(c1)[C@H](C)NC(=O)N1CCN(CC1(C)C)c1ncnc2cc(sc12)N1CCC(F)(F)CC1 InChI=1S/C27H34F2N6O2S/c1-18(19-6-5-7-20(14-19)37-4)32-25(36)35-13-12-34(16-26(35,2)3)24-23-21(30-17-31-24)15-22(38-23)33-10-8-27(28,29)9-11-33/h5-7,14-15,17-18H,8-13,16H2,1-4H3,(H,32,36)/t18-/m0/s1 WPEAQUCGYAAONK-SFHVURJKSA-N 369363 4-[6-(4,4-difluoro-1-piperidyl)thieno[3,2- d]pyrimidin-4-yl]-N-[(1S)-1-(3- methoxyphenyl)ethyl]-2,2-dimethyl- piperazine-1-carboxamide::US10227357, Compound P-0680 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369363 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369363&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 73389623 402366157 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729712 COc1cccc(c1)[C@H](C)NC(=O)N1CCN(CC1(C)C)c1ncnc2cc(sc12)N1CCC(F)(F)CC1 InChI=1S/C27H34F2N6O2S/c1-18(19-6-5-7-20(14-19)37-4)32-25(36)35-13-12-34(16-26(35,2)3)24-23-21(30-17-31-24)15-22(38-23)33-10-8-27(28,29)9-11-33/h5-7,14-15,17-18H,8-13,16H2,1-4H3,(H,32,36)/t18-/m0/s1 WPEAQUCGYAAONK-SFHVURJKSA-N 369363 4-[6-(4,4-difluoro-1-piperidyl)thieno[3,2- d]pyrimidin-4-yl]-N-[(1S)-1-(3- methoxyphenyl)ethyl]-2,2-dimethyl- piperazine-1-carboxamide::US10227357, Compound P-0680 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369363 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369363&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 73389623 402366157 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729713 CCOC(=O)N1CCN(CC1)c1cc2ncnc(N3CCN(C(=O)N[C@@H](C)c4cccc(OC)c4)C(C)(C)C3)c2s1 InChI=1S/C29H39N7O4S/c1-6-40-28(38)34-12-10-33(11-13-34)24-17-23-25(41-24)26(31-19-30-23)35-14-15-36(29(3,4)18-35)27(37)32-20(2)21-8-7-9-22(16-21)39-5/h7-9,16-17,19-20H,6,10-15,18H2,1-5H3,(H,32,37)/t20-/m0/s1 TZFKARXMQALQOW-FQEVSTJZSA-N 369364 US10227357, Compound P-0681::ethyl 4-[4-[4-[[(1S)-1-(3- methoxyphenyl)ethyl]carbamoyl]-3,3- dimethyl-piperazin-1-yl]thieno[3,2- d]pyrimidin-6-yl]piperazine-1-carboxylate Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369364 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369364&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 73389624 402366158 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729714 CCOC(=O)N1CCN(CC1)c1cc2ncnc(N3CCN(C(=O)N[C@@H](C)c4cccc(OC)c4)C(C)(C)C3)c2s1 InChI=1S/C29H39N7O4S/c1-6-40-28(38)34-12-10-33(11-13-34)24-17-23-25(41-24)26(31-19-30-23)35-14-15-36(29(3,4)18-35)27(37)32-20(2)21-8-7-9-22(16-21)39-5/h7-9,16-17,19-20H,6,10-15,18H2,1-5H3,(H,32,37)/t20-/m0/s1 TZFKARXMQALQOW-FQEVSTJZSA-N 369364 US10227357, Compound P-0681::ethyl 4-[4-[4-[[(1S)-1-(3- methoxyphenyl)ethyl]carbamoyl]-3,3- dimethyl-piperazin-1-yl]thieno[3,2- d]pyrimidin-6-yl]piperazine-1-carboxylate Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369364 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369364&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 73389624 402366158 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729715 C[C@H](NC(=O)N1CCN(CC1(C)C)c1ncnc2ccsc12)c1cccc(Cl)c1 InChI=1S/C21H24ClN5OS/c1-14(15-5-4-6-16(22)11-15)25-20(28)27-9-8-26(12-21(27,2)3)19-18-17(7-10-29-18)23-13-24-19/h4-7,10-11,13-14H,8-9,12H2,1-3H3,(H,25,28)/t14-/m0/s1 PTZXWPWWGHRPCH-AWEZNQCLSA-N 369360 N-[(1S)-1-(3-chlorophenyl)ethyl]-2,2- dimethyl-4-thieno[3,2-d]pyrimidin-4-yl- piperazine-1-carboxamide::US10227357, Compound P-0677::US10227357, Compound P-0682 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369360 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369360&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 73389625 402366154 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729716 C[C@H](NC(=O)N1CCN(CC1(C)C)c1ncnc2ccsc12)c1cccc(Cl)c1 InChI=1S/C21H24ClN5OS/c1-14(15-5-4-6-16(22)11-15)25-20(28)27-9-8-26(12-21(27,2)3)19-18-17(7-10-29-18)23-13-24-19/h4-7,10-11,13-14H,8-9,12H2,1-3H3,(H,25,28)/t14-/m0/s1 PTZXWPWWGHRPCH-AWEZNQCLSA-N 369360 N-[(1S)-1-(3-chlorophenyl)ethyl]-2,2- dimethyl-4-thieno[3,2-d]pyrimidin-4-yl- piperazine-1-carboxamide::US10227357, Compound P-0677::US10227357, Compound P-0682 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369360 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369360&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 73389625 402366154 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729717 COc1cccc(c1)[C@H](C)NC(=O)N1CCN(C[C@H]1C)c1ncnc2[nH]c(C)cc12 369366 (2R)-N-[(1S)-1-(3-methoxyphenyl)ethyl]-2- methyl-4-(6-methyl-7H-pyrrolo[2,3- d]pyrimidin-4-yl)piperazine-1- carboxamide::US10227357, Compound P-0683 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369366 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369366&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114232 402366159 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729718 COc1cccc(c1)[C@H](C)NC(=O)N1CCN(C[C@H]1C)c1ncnc2[nH]c(C)cc12 369366 (2R)-N-[(1S)-1-(3-methoxyphenyl)ethyl]-2- methyl-4-(6-methyl-7H-pyrrolo[2,3- d]pyrimidin-4-yl)piperazine-1- carboxamide::US10227357, Compound P-0683 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369366 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369366&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114232 402366159 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729719 C[C@H](NC(=O)N1CCN(C[C@H]1C)c1ncnc2[nH]c(C)cc12)c1cccc(F)c1 369367 (2R)-N-[(1S)-1-(3-fluorophenyl)ethyl]-2- methyl-4-(6-methyl-7H-pyrrolo[2,3- d]pyrimidin-4-yl)piperazine-1- carboxamide::US10227357, Compound P-0684 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369367 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369367&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114906 402366160 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729720 C[C@H](NC(=O)N1CCN(C[C@H]1C)c1ncnc2[nH]c(C)cc12)c1cccc(F)c1 369367 (2R)-N-[(1S)-1-(3-fluorophenyl)ethyl]-2- methyl-4-(6-methyl-7H-pyrrolo[2,3- d]pyrimidin-4-yl)piperazine-1- carboxamide::US10227357, Compound P-0684 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369367 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369367&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114906 402366160 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729721 C[C@H](NC(=O)N1CCN(CC1(C)C)c1ncnc2[nH]c(cc12)-c1ccc(cc1)C#N)c1ccc(F)cc1 369368 4-[6-(4-cyanophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[(1S)-1-(4- fluorophenyl)ethyl]-2,2-dimethyl- piperazine-1-carboxamide::US10227357, Compound P-0685 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369368 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369368&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 73389534 402366161 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729722 C[C@H](NC(=O)N1CCN(CC1(C)C)c1ncnc2[nH]c(cc12)-c1ccc(cc1)C#N)c1ccc(Cl)cc1 369369 N-[(1S)-1-(4-chlorophenyl)ethyl]-4-[6-(4- cyanophenyl)-7H-pyrrolo[2,3-d]pyrimidin- 4-yl]-2,2-dimethyl-piperazine-1- carboxamide::US10227357, Compound P-0686 Mast/stem cell growth factor receptor Kit [D816V] Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369369 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369369&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 73389535 402366162 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729723 COc1cccc(c1)[C@H](C)NC(=O)N1CCN(CC1(C)C)c1ncnc2[nH]c(cc12)-c1ccc(cc1)C#N 369370 4-[6-(4-cyanophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[(1S)-1-(3- methoxyphenyl)ethyl]-2,2-dimethyl- piperazine-1-carboxamide::US10227357, Compound P-0687 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369370 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369370&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 73389536 402366163 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729724 COc1cccc(c1)[C@H](C)NC(=O)N1CCN(CC1(C)C)c1ncnc2[nH]c(cc12)-c1ccc(cc1)C#N 369370 4-[6-(4-cyanophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[(1S)-1-(3- methoxyphenyl)ethyl]-2,2-dimethyl- piperazine-1-carboxamide::US10227357, Compound P-0687 Mast/stem cell growth factor receptor Kit [D816V] Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369370 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369370&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 73389536 402366163 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729725 C[C@H](NC(=O)N1CCN(CC1(C)C)c1ncnc2[nH]c(cc12)-c1ccc(cc1)C#N)c1cccc(F)c1 369371 4-[6-(4-cyanophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[(1S)-1-(3- fluorophenyl)ethyl]-2,2-dimethyl- piperazine-1-carboxamide::US10227357, Compound P-0688 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369371 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369371&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 73389622 402366164 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729726 C[C@H](NC(=O)N1CCN(CC1(C)C)c1ncnc2[nH]c(cc12)-c1ccc(cc1)C#N)c1cccc(F)c1 369371 4-[6-(4-cyanophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[(1S)-1-(3- fluorophenyl)ethyl]-2,2-dimethyl- piperazine-1-carboxamide::US10227357, Compound P-0688 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369371 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369371&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 73389622 402366164 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729727 C[C@H](NC(=O)N1CCN(CC1(C)C)c1ncnc2[nH]c(cc12)-c1ccc(cc1)C#N)c1cccc(Cl)c1 369372 N-[(1S)-1-(3-chlorophenyl)ethyl]-4-[6-(4- cyanophenyl)-7H-pyrrolo[2,3-d]pyrimidin- 4-yl]-2,2-dimethyl-piperazine-1- carboxamide::US10227357, Compound P-0689 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369372 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369372&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 73389457 402366165 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729728 C[C@H](NC(=O)N1CCN(CC1(C)C)c1ncnc2[nH]c(cc12)-c1ccc(cc1)C#N)c1cccc(Cl)c1 369372 N-[(1S)-1-(3-chlorophenyl)ethyl]-4-[6-(4- cyanophenyl)-7H-pyrrolo[2,3-d]pyrimidin- 4-yl]-2,2-dimethyl-piperazine-1- carboxamide::US10227357, Compound P-0689 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369372 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369372&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 73389457 402366165 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729729 C[C@H](NC(=O)N1CCN(C[C@H]1C)c1ncnc2[nH]c(cc12)-c1ccc(cc1)C#N)c1ccc(F)cc1 369373 (2R)-4-[6-(4-cyanophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[(1S)-1-(4- fluorophenyl)ethyl]-2-methyl-piperazine- 1-carboxamide::US10227357, Compound P-0690 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369373 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369373&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 73389458 402366166 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729730 C[C@H](NC(=O)N1CCN(C[C@H]1C)c1ncnc2[nH]c(cc12)-c1ccc(cc1)C#N)c1ccc(F)cc1 369373 (2R)-4-[6-(4-cyanophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[(1S)-1-(4- fluorophenyl)ethyl]-2-methyl-piperazine- 1-carboxamide::US10227357, Compound P-0690 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369373 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369373&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 73389458 402366166 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729731 C[C@H](NC(=O)N1CCN(C[C@H]1C)c1ncnc2[nH]c(cc12)-c1ccc(cc1)C#N)c1ccc(Cl)cc1 369374 (2R)-N-[(1S)-1-(4-chlorophenyl)ethyl]-4-[6- (4-cyanophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-2-methyl-piperazine-1- carboxamide::US10227357, Compound P-0691 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369374 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369374&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 73389370 402366167 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729732 C[C@H](NC(=O)N1CCN(C[C@H]1C)c1ncnc2[nH]c(cc12)-c1ccc(cc1)C#N)c1ccc(Cl)cc1 369374 (2R)-N-[(1S)-1-(4-chlorophenyl)ethyl]-4-[6- (4-cyanophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-2-methyl-piperazine-1- carboxamide::US10227357, Compound P-0691 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369374 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369374&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 73389370 402366167 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729733 COc1cccc(c1)[C@H](C)NC(=O)N1CCN(C[C@H]1C)c1ncnc2[nH]c(cc12)-c1ccc(cc1)C#N 369375 (2R)-4-[6-(4-cyanophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[(1S)-1-(3- methoxyphenyl)ethyl]-2-methyl- piperazine-1-carboxamide::US10227357, Compound P-0692 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369375 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369375&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 73389533 402366168 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729734 COc1cccc(c1)[C@H](C)NC(=O)N1CCN(C[C@H]1C)c1ncnc2[nH]c(cc12)-c1ccc(cc1)C#N 369375 (2R)-4-[6-(4-cyanophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[(1S)-1-(3- methoxyphenyl)ethyl]-2-methyl- piperazine-1-carboxamide::US10227357, Compound P-0692 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369375 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369375&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 73389533 402366168 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729735 C[C@H](NC(=O)N1CCN(C[C@H]1C)c1ncnc2[nH]c(cc12)-c1ccc(cc1)C#N)c1cccc(F)c1 369376 (2R)-4-[6-(4-cyanophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[(1S)-1-(3- fluorophenyl)ethyl]-2-methyl-piperazine- 1-carboxamide::US10227357, Compound P-0693 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369376 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369376&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 73389459 402366169 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729736 C[C@H](NC(=O)N1CCN(C[C@H]1C)c1ncnc2[nH]c(cc12)-c1ccc(cc1)C#N)c1cccc(Cl)c1 369377 (2R)-N-[(1S)-1-(3-chlorophenyl)ethyl]-4-[6- (4-cyanophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-2-methyl-piperazine-1- carboxamide::US10227357, Compound P-0694 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369377 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369377&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 73389532 402366170 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729737 C[C@H](NC(=O)N1CCN(C[C@H]1C)c1ncnc2[nH]c(cc12)-c1ccc(cc1)C#N)c1cccc(Cl)c1 369377 (2R)-N-[(1S)-1-(3-chlorophenyl)ethyl]-4-[6- (4-cyanophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-2-methyl-piperazine-1- carboxamide::US10227357, Compound P-0694 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369377 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369377&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 73389532 402366170 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729738 COc1cc(ccn1)-c1cc2c(ncnc2[nH]1)N1CCN([C@H](C)C1)C(=O)N[C@@H](C)c1ccc(F)cc1 369378 (2R)-N-[(1S)-1-(4-fluorophenyl)ethyl]-4-[6- (2-methoxy-4-pyridyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-2-methyl-piperazine-1- carboxamide::US10227357, Compound P-0695 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369378 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369378&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114659 402366171 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729739 COc1cc(ccn1)-c1cc2c(ncnc2[nH]1)N1CCN([C@H](C)C1)C(=O)N[C@@H](C)c1ccc(F)cc1 369378 (2R)-N-[(1S)-1-(4-fluorophenyl)ethyl]-4-[6- (2-methoxy-4-pyridyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-2-methyl-piperazine-1- carboxamide::US10227357, Compound P-0695 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369378 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369378&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114659 402366171 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729740 C[C@H](NC(=O)N1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(cc1)C#N)c1ccc(F)cc1 369379 4-[6-(4-cyanophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[(1S)-1-(4- fluorophenyl)ethyl]piperazine-1- carboxamide::US10227357, Compound P-0696 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369379 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369379&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 73389373 402366172 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729741 C[C@H](NC(=O)N1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(cc1)C#N)c1cccc(Cl)c1 369380 N-[(1S)-1-(3-chlorophenyl)ethyl]-4-[6-(4- cyanophenyl)-7H-pyrrolo[2,3-d]pyrimidin- 4-yl]piperazine-1-carboxamide::US10227357, Compound P-0697 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369380 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369380&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 73389374 402366173 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729742 C[C@H](NC(=O)N1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(cc1)C#N)c1cccc(Cl)c1 369380 N-[(1S)-1-(3-chlorophenyl)ethyl]-4-[6-(4- cyanophenyl)-7H-pyrrolo[2,3-d]pyrimidin- 4-yl]piperazine-1-carboxamide::US10227357, Compound P-0697 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369380 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369380&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 73389374 402366173 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729743 C[C@H](NC(=O)N1CCN(CC1(C)C)c1ncnc2[nH]c(cc12)-c1ccc(cc1)C#N)c1cccc(OC(F)F)c1 369381 4-[6-(4-cyanophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[(1S)-1-[3- (difluoromethoxy)phenyl]ethyl]-2,2- dimethyl-piperazine-1-carboxamide::US10227357, Compound P-0698 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369381 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369381&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 73389455 402366174 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729744 C[C@H](NC(=O)N1CCN(C[C@H]1C)c1ncnc2[nH]c(cc12)-c1ccc(cc1)C#N)c1cccc(OC(F)F)c1 369382 (2R)-4-[6-(4-cyanophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[(1S)-1-[3- (difluoromethoxy)phenyl]ethyl]-2-methyl- piperazine-1-carboxamide::US10227357, Compound P-0699 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369382 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369382&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115295 402366175 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729745 C[C@H](NC(=O)N1CCN(CC1(C)C)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1)c1ccc(Cl)cc1 369383 N-[(1S)-1-(4-chlorophenyl)ethyl]-4-[6-(4- fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidin- 4-yl]-2,2-dimethyl-piperazine-1- carboxamide::US10227357, Compound P-0700 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369383 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369383&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114449 402366176 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729746 C[C@H](NC(=O)N1CCN(CC1(C)C)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1)c1ccc(Cl)cc1 369383 N-[(1S)-1-(4-chlorophenyl)ethyl]-4-[6-(4- fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidin- 4-yl]-2,2-dimethyl-piperazine-1- carboxamide::US10227357, Compound P-0700 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369383 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369383&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114449 402366176 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729747 C[C@H](NC(=O)N1CCN(C[C@H]1C)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1)c1cccc(Cl)c1 369384 (2R)-N-[(1S)-1-(3-chlorophenyl)ethyl]-4-[6- (4-fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-2-methyl-piperazine-1- carboxamide::US10227357, Compound P-0701 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369384 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369384&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 73389295 402366177 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729748 C[C@H](NC(=O)N1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(cc1)C#N)c1ccc(Cl)cc1 369385 N-[(1S)-1-(4-chlorophenyl)ethyl]-4-[6-(4- cyanophenyl)-7H-pyrrolo[2,3-d]pyrimidin- 4-yl]piperazine-1-carboxamide::US10227357, Compound P-0702 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369385 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369385&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114970 402366178 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729749 CC(NC(=O)N1CCN(CC1)c1ncnc2cc(sc12)-c1ccc(F)cc1)c1ccc(C)s1 InChI=1S/C24H24FN5OS2/c1-15-3-8-20(32-15)16(2)28-24(31)30-11-9-29(10-12-30)23-22-19(26-14-27-23)13-21(33-22)17-4-6-18(25)7-5-17/h3-8,13-14,16H,9-12H2,1-2H3,(H,28,31) RGMZMROOQGKZFI-UHFFFAOYSA-N 369386 4-[6-(4-fluorophenyl)thieno[3,2- d]pyrimidin-4-yl]-N-[1-(5-methyl-2- thienyl)ethyl]piperazine-1-carboxamide::US10227357, Compound P-0703 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369386 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369386&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 73389626 402366179 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729750 C[C@@H](NC(=O)N1CC2CCC1CN2c1ncnc2cc(sc12)-c1cn(C)nc1C)c1ccc(F)cc1 InChI=1S/C26H28FN7OS/c1-15(17-4-6-18(27)7-5-17)30-26(35)34-12-19-8-9-20(34)11-33(19)25-24-22(28-14-29-25)10-23(36-24)21-13-32(3)31-16(21)2/h4-7,10,13-15,19-20H,8-9,11-12H2,1-3H3,(H,30,35)/t15-,19?,20?/m1/s1 RSNCJBWVILSCSB-APMMTJHUSA-N 369387 5-[6-(1,3-dimethylpyrazol-4-yl)thieno[3,2- d]pyrimidin-4-yl]-N-[(1R)-1-(4- fluorophenyl)ethyl]-2,5- diazabicyclo[2.2.2]octane-2-carboxamide::US10227357, Compound P-0704 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369387 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369387&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114397 402366180 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729759 Fc1ccc(cc1)-c1cc2ncnc(N3CCN(CC3)C(=O)NCc3cccs3)c2s1 InChI=1S/C22H20FN5OS2/c23-16-5-3-15(4-6-16)19-12-18-20(31-19)21(26-14-25-18)27-7-9-28(10-8-27)22(29)24-13-17-2-1-11-30-17/h1-6,11-12,14H,7-10,13H2,(H,24,29) WCOWNLVZINMYHM-UHFFFAOYSA-N 369388 4-[6-(4-fluorophenyl)thieno[3,2- d]pyrimidin-4-yl]-N-(2- thienylmethyl)piperazine-1-carboxamide::US10227357, Compound P-0709 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369388 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369388&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 73389708 402366181 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729760 Fc1ccc(cc1)-c1cc2ncnc(N3CCN(CC3)C(=O)NCc3cccs3)c2s1 InChI=1S/C22H20FN5OS2/c23-16-5-3-15(4-6-16)19-12-18-20(31-19)21(26-14-25-18)27-7-9-28(10-8-27)22(29)24-13-17-2-1-11-30-17/h1-6,11-12,14H,7-10,13H2,(H,24,29) WCOWNLVZINMYHM-UHFFFAOYSA-N 369388 4-[6-(4-fluorophenyl)thieno[3,2- d]pyrimidin-4-yl]-N-(2- thienylmethyl)piperazine-1-carboxamide::US10227357, Compound P-0709 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369388 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369388&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 73389708 402366181 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729761 COc1cc(ccn1)-c1cc2c(ncnc2[nH]1)N1CCN(C(=O)N[C@@H](C)c2ccc(Cl)cc2)C(C)(C)C1 369389 N-[(1S)-1-(4-chlorophenyl)ethyl]-4-[6-(2- methoxy-4-pyridyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-2,2-dimethyl-piperazine- 1-carboxamide::US10227357, Compound P-0710 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369389 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369389&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 73389371 402366182 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729762 COc1cc(ccn1)-c1cc2c(ncnc2[nH]1)N1CCN(C(=O)N[C@@H](C)c2ccc(Cl)cc2)C(C)(C)C1 369389 N-[(1S)-1-(4-chlorophenyl)ethyl]-4-[6-(2- methoxy-4-pyridyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-2,2-dimethyl-piperazine- 1-carboxamide::US10227357, Compound P-0710 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369389 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369389&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 73389371 402366182 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729763 COc1cc(ccn1)-c1cc2c(ncnc2[nH]1)N1CCN([C@H](C)C1)C(=O)N[C@@H](C)c1cccc(Cl)c1 369390 (2R)-N-[(1S)-1-(3-chlorophenyl)ethyl]-4-[6- (2-methoxy-4-pyridyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-2-methyl-piperazine-1- carboxamide::US10227357, Compound P-0711 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369390 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369390&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114715 402366183 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729764 C[C@H](NC(=O)N1CCN(C[C@H]1C)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1)c1ccc(C)cc1 369391 (2R)-4-[6-(4-fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-2-methyl-N-[(1S)-1-(p- tolyl)ethyl]piperazine-1-carboxamide::US10227357, Compound P-0712 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369391 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369391&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114998 402366184 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729765 C[C@H](NC(=O)N1CCN(C[C@H]1C)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1)c1ccc(C)cc1 369391 (2R)-4-[6-(4-fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-2-methyl-N-[(1S)-1-(p- tolyl)ethyl]piperazine-1-carboxamide::US10227357, Compound P-0712 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369391 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369391&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114998 402366184 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729766 C[C@H](NC(=O)N1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1)c1ccc(C)cc1 369392 4-[6-(4-fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[(1S)-1-(p- tolyl)ethyl]piperazine-1-carboxamide::US10227357, Compound P-0713 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369392 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369392&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 73389372 402366185 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729767 CCOc1cccc(c1)-c1[nH]c(nc1C)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccnc(OC)c1 InChI=1S/C29H31N7O2/c1-4-38-22-7-5-6-21(14-22)26-18(2)33-27(35-26)19-9-12-36(13-10-19)29-23-16-24(34-28(23)31-17-32-29)20-8-11-30-25(15-20)37-3/h5-8,11,14-17,19H,4,9-10,12-13H2,1-3H3,(H,33,35)(H,31,32,34) LRANSWZLSNIOEP-UHFFFAOYSA-N 342200 4-[4-[5-(3-ethoxyphenyl)-4-methyl-1H- imidazol-2-yl]-1-piperidyl]-6-(2- methoxy-4-pyridyl)-7H-pyrrolo[2,3- d]pyrimidine::US10227357, Compound P-0714::US9771369, Compound P-3034 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=342200 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=342200&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114599 385212924 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729768 CCOc1cccc(c1)-c1[nH]c(nc1C)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccnc(OC)c1 InChI=1S/C29H31N7O2/c1-4-38-22-7-5-6-21(14-22)26-18(2)33-27(35-26)19-9-12-36(13-10-19)29-23-16-24(34-28(23)31-17-32-29)20-8-11-30-25(15-20)37-3/h5-8,11,14-17,19H,4,9-10,12-13H2,1-3H3,(H,33,35)(H,31,32,34) LRANSWZLSNIOEP-UHFFFAOYSA-N 342200 4-[4-[5-(3-ethoxyphenyl)-4-methyl-1H- imidazol-2-yl]-1-piperidyl]-6-(2- methoxy-4-pyridyl)-7H-pyrrolo[2,3- d]pyrimidine::US10227357, Compound P-0714::US9771369, Compound P-3034 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=342200 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=342200&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114599 385212924 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729769 C[C@H](NC(=O)N1CCN(C[C@H]1C)c1ncnc2[nH]c(cc12)-c1cn(C)nc1C)c1ccc(F)cc1 369394 (2R)-4-[6-(1,3-dimethylpyrazol-4-yl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]-N-[(1S)-1-(4- fluorophenyl)ethyl]-2-methyl-piperazine- 1-carboxamide::US10227357, Compound P-0715 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369394 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369394&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 73389291 402366187 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729770 C[C@H](NC(=O)N1CCN(C[C@H]1C)c1ncnc2[nH]c(cc12)-c1cn(C)nc1C)c1ccc(F)cc1 369394 (2R)-4-[6-(1,3-dimethylpyrazol-4-yl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]-N-[(1S)-1-(4- fluorophenyl)ethyl]-2-methyl-piperazine- 1-carboxamide::US10227357, Compound P-0715 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369394 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369394&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 73389291 402366187 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729771 C[C@H](NC(=O)N1CCN(CC1)c1ncnc2[nH]c(cc12)-c1cn(C)nc1C)c1ccc(Cl)cc1 369395 N-[(1S)-1-(4-chlorophenyl)ethyl]-4-[6-(1,3- dimethylpyrazol-4-yl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]piperazine-1- carboxamide::US10227357, Compound P-0716 Mast/stem cell growth factor receptor Kit Human 105000 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369395 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369395&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 73389292 402366188 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729772 C[C@H](NC(=O)N1CCN(CC1)c1ncnc2[nH]c(cc12)-c1cn(C)nc1C)c1ccc(Cl)cc1 369395 N-[(1S)-1-(4-chlorophenyl)ethyl]-4-[6-(1,3- dimethylpyrazol-4-yl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]piperazine-1- carboxamide::US10227357, Compound P-0716 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369395 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369395&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 73389292 402366188 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729773 C[C@H](NC(=O)N1CCN(C[C@H]1C)c1ncnc2[nH]c(cc12)-c1cnn(C)c1)c1ccc(Cl)cc1 369396 (2R)-N-[(1S)-1-(4-chlorophenyl)ethyl]-2- methyl-4-[6-(1-methylpyrazol-4-yl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]piperazine-1- carboxamide::US10227357, Compound P-0717 Mast/stem cell growth factor receptor Kit Human 5500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369396 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369396&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114912 402366189 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729774 C[C@H](NC(=O)N1CCN(C[C@H]1C)c1ncnc2[nH]c(cc12)-c1cnn(C)c1)c1ccc(Cl)cc1 369396 (2R)-N-[(1S)-1-(4-chlorophenyl)ethyl]-2- methyl-4-[6-(1-methylpyrazol-4-yl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]piperazine-1- carboxamide::US10227357, Compound P-0717 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369396 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369396&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114912 402366189 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729775 C[C@H](NC(=O)N1CCN(C[C@H]1C)c1ncnc2[nH]c(cc12)-c1cn(C)nc1C)c1ccc(Cl)cc1 369397 (2R)-N-[(1S)-1-(4-chlorophenyl)ethyl]-4-[6- (1,3-dimethylpyrazol-4-yl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-2-methyl-piperazine-1- carboxamide::US10227357, Compound P-0718 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369397 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369397&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114966 402366190 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729776 C[C@H](NC(=O)N1CCN(C[C@H]1C)c1ncnc2[nH]c(cc12)-c1cn(C)nc1C)c1ccc(Cl)cc1 369397 (2R)-N-[(1S)-1-(4-chlorophenyl)ethyl]-4-[6- (1,3-dimethylpyrazol-4-yl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-2-methyl-piperazine-1- carboxamide::US10227357, Compound P-0718 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369397 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369397&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114966 402366190 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729777 C[C@H](NC(=O)N1CCN(CC1(C)C)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1)c1ccc(C)cc1 369398 4-[6-(4-fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-2,2-dimethyl-N-[(1S)-1- (p-tolyl)ethyl]piperazine-1-carboxamide::US10227357, Compound P-0719 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369398 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369398&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 73389294 402366191 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729778 C[C@H](NC(=O)N1CCN(CC1(C)C)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1)c1ccc(C)cc1 369398 4-[6-(4-fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-2,2-dimethyl-N-[(1S)-1- (p-tolyl)ethyl]piperazine-1-carboxamide::US10227357, Compound P-0719 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369398 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369398&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 73389294 402366191 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729779 C[C@H](NC(=O)N1CCN(CC1(C)C)c1ncnc2[nH]c(cc12)-c1cnn(C)c1)c1ccc(F)cc1 369399 N-[(1S)-1-(4-fluorophenyl)ethyl]-2,2- dimethyl-4-[6-(1-methylpyrazol-4-yl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]piperazine-1- carboxamide::US10227357, Compound P-0720 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369399 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369399&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 73389136 402366192 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729780 C[C@H](NC(=O)N1CCN(CC1(C)C)c1ncnc2[nH]c(cc12)-c1cnn(C)c1)c1ccc(F)cc1 369399 N-[(1S)-1-(4-fluorophenyl)ethyl]-2,2- dimethyl-4-[6-(1-methylpyrazol-4-yl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]piperazine-1- carboxamide::US10227357, Compound P-0720 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369399 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369399&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 73389136 402366192 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729781 C[C@H](NC(=O)N1CCN(CC1(C)C)c1ncnc2[nH]c(cc12)-c1cn(C)nc1C)c1ccc(F)cc1 369400 4-[6-(1,3-dimethylpyrazol-4-yl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]-N-[(1S)-1-(4- fluorophenyl)ethyl]-2,2-dimethyl- piperazine-1-carboxamide::US10227357, Compound P-0721 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369400 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369400&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 73389215 402366193 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729782 C[C@H](NC(=O)N1CCN(CC1(C)C)c1ncnc2[nH]c(cc12)-c1cn(C)nc1C)c1ccc(F)cc1 369400 4-[6-(1,3-dimethylpyrazol-4-yl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]-N-[(1S)-1-(4- fluorophenyl)ethyl]-2,2-dimethyl- piperazine-1-carboxamide::US10227357, Compound P-0721 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369400 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369400&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 73389215 402366193 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729783 C[C@H](NC(=O)N1CCN(CC1(C)C)c1ncnc2[nH]c(cc12)-c1cnn(C)c1)c1ccc(Cl)cc1 369401 N-[(1S)-1-(4-chlorophenyl)ethyl]-2,2- dimethyl-4-[6-(1-methylpyrazol-4-yl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]piperazine-1- carboxamide::US10227357, Compound P-0722 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369401 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369401&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 73389216 402366194 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729784 C[C@H](NC(=O)N1CCN(CC1(C)C)c1ncnc2[nH]c(cc12)-c1cnn(C)c1)c1ccc(Cl)cc1 369401 N-[(1S)-1-(4-chlorophenyl)ethyl]-2,2- dimethyl-4-[6-(1-methylpyrazol-4-yl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]piperazine-1- carboxamide::US10227357, Compound P-0722 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369401 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369401&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 73389216 402366194 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729785 C[C@H](NC(=O)N1CCN(CC1(C)C)c1ncnc2[nH]c(cc12)-c1cn(C)nc1C)c1ccc(Cl)cc1 369402 N-[(1S)-1-(4-chlorophenyl)ethyl]-4-[6-(1,3- dimethylpyrazol-4-yl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-2,2-dimethyl-piperazine- 1-carboxamide::US10227357, Compound P-0723 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369402 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369402&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 73389217 402366195 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729786 C[C@H](NC(=O)N1CCN(CC1(C)C)c1ncnc2[nH]c(cc12)-c1cn(C)nc1C)c1ccc(Cl)cc1 369402 N-[(1S)-1-(4-chlorophenyl)ethyl]-4-[6-(1,3- dimethylpyrazol-4-yl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-2,2-dimethyl-piperazine- 1-carboxamide::US10227357, Compound P-0723 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369402 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369402&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 73389217 402366195 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729787 C[C@H](NC(=O)N1CCN(CC1)c1ncnc2[nH]c(cc12)-c1cn(C)nc1C)c1ccc(F)cc1 369403 4-[6-(1,3-dimethylpyrazol-4-yl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]-N-[(1S)-1-(4- fluorophenyl)ethyl]piperazine-1- carboxamide::US10227357, Compound P-0724 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369403 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369403&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 73389218 402366196 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729788 C[C@H](NC(=O)N1CCN(CC1)c1ncnc2[nH]c(cc12)-c1cn(C)nc1C)c1ccc(F)cc1 369403 4-[6-(1,3-dimethylpyrazol-4-yl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]-N-[(1S)-1-(4- fluorophenyl)ethyl]piperazine-1- carboxamide::US10227357, Compound P-0724 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369403 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369403&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 73389218 402366196 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729789 C[C@H](NC(=O)N1CCN(C[C@H]1C)c1ncnc2[nH]c(cc12)-c1cnn(C)c1)c1ccc(F)cc1 369404 (2R)-N-[(1S)-1-(4-fluorophenyl)ethyl]-2- methyl-4-[6-(1-methylpyrazol-4-yl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]piperazine-1- carboxamide::US10227357, Compound P-0725 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369404 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369404&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 73389219 402366197 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729790 C[C@H](NC(=O)N1CCN(C[C@H]1C)c1ncnc2[nH]c(cc12)-c1cnn(C)c1)c1ccc(F)cc1 369404 (2R)-N-[(1S)-1-(4-fluorophenyl)ethyl]-2- methyl-4-[6-(1-methylpyrazol-4-yl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]piperazine-1- carboxamide::US10227357, Compound P-0725 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369404 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369404&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 73389219 402366197 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729791 CCc1ccc(cc1)S(=O)(=O)NC1CCN(CC1)c1ncnc2[nH]c(cc12)-c1cn(C)nc1C InChI=1S/C24H29N7O2S/c1-4-17-5-7-19(8-6-17)34(32,33)29-18-9-11-31(12-10-18)24-20-13-22(27-23(20)25-15-26-24)21-14-30(3)28-16(21)2/h5-8,13-15,18,29H,4,9-12H2,1-3H3,(H,25,26,27) MMRGIKRBTWXSKJ-UHFFFAOYSA-N 369405 N-[1-[6-(1,3-dimethylpyrazol-4-yl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]-4- piperidyl]-4-ethyl-benzenesulfonamide::US10227357, Compound P-0726 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369405 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369405&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114829 402366198 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729792 CCc1ccc(cc1)S(=O)(=O)NC1CCN(CC1)c1ncnc2[nH]c(cc12)-c1cn(C)nc1C InChI=1S/C24H29N7O2S/c1-4-17-5-7-19(8-6-17)34(32,33)29-18-9-11-31(12-10-18)24-20-13-22(27-23(20)25-15-26-24)21-14-30(3)28-16(21)2/h5-8,13-15,18,29H,4,9-12H2,1-3H3,(H,25,26,27) MMRGIKRBTWXSKJ-UHFFFAOYSA-N 369405 N-[1-[6-(1,3-dimethylpyrazol-4-yl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]-4- piperidyl]-4-ethyl-benzenesulfonamide::US10227357, Compound P-0726 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369405 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369405&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114829 402366198 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729793 CCc1ccc(cc1)S(=O)(=O)NC1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccnc(OC)c1 InChI=1S/C25H28N6O3S/c1-3-17-4-6-20(7-5-17)35(32,33)30-19-9-12-31(13-10-19)25-21-15-22(29-24(21)27-16-28-25)18-8-11-26-23(14-18)34-2/h4-8,11,14-16,19,30H,3,9-10,12-13H2,1-2H3,(H,27,28,29) QXUREADOESZDSF-UHFFFAOYSA-N 369406 4-ethyl-N-[1-[6-(2-methoxy-4-pyridyl)- 7H-pyrrolo[2,3-d]pyrimidin-4-yl]-4- piperidyl]benzenesulfonamide::US10227357, Compound P-0727 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369406 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369406&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115456 402366199 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729794 CCc1ccc(cc1)S(=O)(=O)NC1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccnc(OC)c1 InChI=1S/C25H28N6O3S/c1-3-17-4-6-20(7-5-17)35(32,33)30-19-9-12-31(13-10-19)25-21-15-22(29-24(21)27-16-28-25)18-8-11-26-23(14-18)34-2/h4-8,11,14-16,19,30H,3,9-10,12-13H2,1-2H3,(H,27,28,29) QXUREADOESZDSF-UHFFFAOYSA-N 369406 4-ethyl-N-[1-[6-(2-methoxy-4-pyridyl)- 7H-pyrrolo[2,3-d]pyrimidin-4-yl]-4- piperidyl]benzenesulfonamide::US10227357, Compound P-0727 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369406 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369406&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115456 402366199 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729795 Cc1cc2c(ncnc2[nH]1)N1CCC(CC1)NS(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C18H20ClN5O2S/c1-12-10-16-17(22-12)20-11-21-18(16)24-8-6-14(7-9-24)23-27(25,26)15-4-2-13(19)3-5-15/h2-5,10-11,14,23H,6-9H2,1H3,(H,20,21,22) BVAXSRCAJDSGBW-UHFFFAOYSA-N 369407 4-chloro-N-[1-(6-methyl-7H- pyrrolo[2,3-d]pyrimidin-4-yl)-4- piperidyl]benzenesulfonamide::US10227357, Compound P-0728 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369407 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369407&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115288 402366200 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729796 Cc1cc2c(ncnc2[nH]1)N1CCC(CC1)NS(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C18H20ClN5O2S/c1-12-10-16-17(22-12)20-11-21-18(16)24-8-6-14(7-9-24)23-27(25,26)15-4-2-13(19)3-5-15/h2-5,10-11,14,23H,6-9H2,1H3,(H,20,21,22) BVAXSRCAJDSGBW-UHFFFAOYSA-N 369407 4-chloro-N-[1-(6-methyl-7H- pyrrolo[2,3-d]pyrimidin-4-yl)-4- piperidyl]benzenesulfonamide::US10227357, Compound P-0728 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369407 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369407&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115288 402366200 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729797 Cc1cc2c(ncnc2[nH]1)C1=CCC(CC1)NS(=O)(=O)c1ccc(Cl)cc1 369408 4-chloro-N-[4-(6-methyl-7H-pyrrolo[2,3- d]pyrimidin-4-yl)cyclohex-3-en-1- yl]benzenesulfonamide::US10227357, Compound P-0729 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369408 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369408&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90115494 402366201 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729798 Cc1cc2c(ncnc2[nH]1)C1=CCC(CC1)NS(=O)(=O)c1ccc(Cl)cc1 369408 4-chloro-N-[4-(6-methyl-7H-pyrrolo[2,3- d]pyrimidin-4-yl)cyclohex-3-en-1- yl]benzenesulfonamide::US10227357, Compound P-0729 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369408 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369408&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90115494 402366201 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729799 CCc1ccc(s1)S(=O)(=O)NC1CCN(CC1)c1ncnc2[nH]c(C)cc12 InChI=1S/C18H23N5O2S2/c1-3-14-4-5-16(26-14)27(24,25)22-13-6-8-23(9-7-13)18-15-10-12(2)21-17(15)19-11-20-18/h4-5,10-11,13,22H,3,6-9H2,1-2H3,(H,19,20,21) XPTBCDCIJHCOOY-UHFFFAOYSA-N 369409 5-ethyl-N-[1-(6-methyl-7H-pyrrolo[2,3- d]pyrimidin-4-yl)-4- piperidyl]thiophene-2-sulfonamide::US10227357, Compound P-0730 Mast/stem cell growth factor receptor Kit Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369409 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=359&target=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369409&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit&column=ki&startPg=0&Increment=50&submit=Search 90114517 402366202 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8 Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99 729800 CCc1ccc(s1)S(=O)(=O)NC1CCN(CC1)c1ncnc2[nH]c(C)cc12 InChI=1S/C18H23N5O2S2/c1-3-14-4-5-16(26-14)27(24,25)22-13-6-8-23(9-7-13)18-15-10-12(2)21-17(15)19-11-20-18/h4-5,10-11,13,22H,3,6-9H2,1-2H3,(H,19,20,21) XPTBCDCIJHCOOY-UHFFFAOYSA-N 369409 5-ethyl-N-[1-(6-methyl-7H-pyrrolo[2,3- d]pyrimidin-4-yl)-4- piperidyl]thiophene-2-sulfonamide::US10227357, Compound P-0730 Mast/stem cell growth factor receptor Kit [D816V] Human 500 US Patent 10.7270/Q2HX1FZW aid1798066 US10227357 Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y 3/12/2019 12/27/2019 Plexxikon Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=369409 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=360&target=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=369409&enzyme=Mast%2Fstem+cell+growth+factor+receptor+Kit+%5BD816V%5D&column=ki&startPg=0&Increment=50&submit=Search 90114517 402366202 1 MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV 2EC8,8DFM,8DFP Mast/stem cell growth factor receptor Kit KIT_HUMAN P10721 B5A956 D5LXN2 D5M931 F5H8F8 Q6IQ28 Q99662 Q9UM99