BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Date of publication Date in BindingDB Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID PubChem SID ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence 1 PDB ID(s) of Target Chain 1 UniProt (SwissProt) Recommended Name of Target Chain 1 UniProt (SwissProt) Entry Name of Target Chain 1 UniProt (SwissProt) Primary ID of Target Chain 1 UniProt (SwissProt) Secondary ID(s) of Target Chain 1 UniProt (SwissProt) Alternative ID(s) of Target Chain 1 UniProt (TrEMBL) Submitted Name of Target Chain 1 UniProt (TrEMBL) Entry Name of Target Chain 1 UniProt (TrEMBL) Primary ID of Target Chain 1 UniProt (TrEMBL) Secondary ID(s) of Target Chain 1 UniProt (TrEMBL) Alternative ID(s) of Target Chain 1 BindingDB Target Chain Sequence 2 PDB ID(s) of Target Chain 2 UniProt (SwissProt) Recommended Name of Target Chain 2 UniProt (SwissProt) Entry Name of Target Chain 2 UniProt (SwissProt) Primary ID of Target Chain 2 UniProt (SwissProt) Secondary ID(s) of Target Chain 2 UniProt (SwissProt) Alternative ID(s) of Target Chain 2 UniProt (TrEMBL) Submitted Name of Target Chain 2 UniProt (TrEMBL) Entry Name of Target Chain 2 UniProt (TrEMBL) Primary ID of Target Chain 2 UniProt (TrEMBL) Secondary ID(s) of Target Chain 2 UniProt (TrEMBL) Alternative ID(s) of Target Chain 2 BindingDB Target Chain Sequence 3 PDB ID(s) of Target Chain 3 UniProt (SwissProt) Recommended Name of Target Chain 3 UniProt (SwissProt) Entry Name of Target Chain 3 UniProt (SwissProt) Primary ID of Target Chain 3 UniProt (SwissProt) Secondary ID(s) of Target Chain 3 UniProt (SwissProt) Alternative ID(s) of Target Chain 3 UniProt (TrEMBL) Submitted Name of Target Chain 3 UniProt (TrEMBL) Entry Name of Target Chain 3 UniProt (TrEMBL) Primary ID of Target Chain 3 UniProt (TrEMBL) Secondary ID(s) of Target Chain 3 UniProt (TrEMBL) Alternative ID(s) of Target Chain 3 BindingDB Target Chain Sequence 4 PDB ID(s) of Target Chain 4 UniProt (SwissProt) Recommended Name of Target Chain 4 UniProt (SwissProt) Entry Name of Target Chain 4 UniProt (SwissProt) Primary ID of Target Chain 4 UniProt (SwissProt) Secondary ID(s) of Target Chain 4 UniProt (SwissProt) Alternative ID(s) of Target Chain 4 UniProt (TrEMBL) Submitted Name of Target Chain 4 UniProt (TrEMBL) Entry Name of Target Chain 4 UniProt (TrEMBL) Primary ID of Target Chain 4 UniProt (TrEMBL) Secondary ID(s) of Target Chain 4 UniProt (TrEMBL) Alternative ID(s) of Target Chain 4 BindingDB Target Chain Sequence 5 PDB ID(s) of Target Chain 5 UniProt (SwissProt) Recommended Name of Target Chain 5 UniProt (SwissProt) Entry Name of Target Chain 5 UniProt (SwissProt) Primary ID of Target Chain 5 UniProt (SwissProt) Secondary ID(s) of Target Chain 5 UniProt (SwissProt) Alternative ID(s) of Target Chain 5 UniProt (TrEMBL) Submitted Name of Target Chain 5 UniProt (TrEMBL) Entry Name of Target Chain 5 UniProt (TrEMBL) Primary ID of Target Chain 5 UniProt (TrEMBL) Secondary ID(s) of Target Chain 5 UniProt (TrEMBL) Alternative ID(s) of Target Chain 5 BindingDB Target Chain Sequence 6 PDB ID(s) of Target Chain 6 UniProt (SwissProt) Recommended Name of Target Chain 6 UniProt (SwissProt) Entry Name of Target Chain 6 UniProt (SwissProt) Primary ID of Target Chain 6 UniProt (SwissProt) Secondary ID(s) of Target Chain 6 UniProt (SwissProt) Alternative ID(s) of Target Chain 6 UniProt (TrEMBL) Submitted Name of Target Chain 6 UniProt (TrEMBL) Entry Name of Target Chain 6 UniProt (TrEMBL) Primary ID of Target Chain 6 UniProt (TrEMBL) Secondary ID(s) of Target Chain 6 UniProt (TrEMBL) Alternative ID(s) of Target Chain 6 BindingDB Target Chain Sequence 7 PDB ID(s) of Target Chain 7 UniProt (SwissProt) Recommended Name of Target Chain 7 UniProt (SwissProt) Entry Name of Target Chain 7 UniProt (SwissProt) Primary ID of Target Chain 7 UniProt (SwissProt) Secondary ID(s) of Target Chain 7 UniProt (SwissProt) Alternative ID(s) of Target Chain 7 UniProt (TrEMBL) Submitted Name of Target Chain 7 UniProt (TrEMBL) Entry Name of Target Chain 7 UniProt (TrEMBL) Primary ID of Target Chain 7 UniProt (TrEMBL) Secondary ID(s) of Target Chain 7 UniProt (TrEMBL) Alternative ID(s) of Target Chain 7 BindingDB Target Chain Sequence 8 PDB ID(s) of Target Chain 8 UniProt (SwissProt) Recommended Name of Target Chain 8 UniProt (SwissProt) Entry Name of Target Chain 8 UniProt (SwissProt) Primary ID of Target Chain 8 UniProt (SwissProt) Secondary ID(s) of Target Chain 8 UniProt (SwissProt) Alternative ID(s) of Target Chain 8 UniProt (TrEMBL) Submitted Name of Target Chain 8 UniProt (TrEMBL) Entry Name of Target Chain 8 UniProt (TrEMBL) Primary ID of Target Chain 8 UniProt (TrEMBL) Secondary ID(s) of Target Chain 8 UniProt (TrEMBL) Alternative ID(s) of Target Chain 8 BindingDB Target Chain Sequence 9 PDB ID(s) of Target Chain 9 UniProt (SwissProt) Recommended Name of Target Chain 9 UniProt (SwissProt) Entry Name of Target Chain 9 UniProt (SwissProt) Primary ID of Target Chain 9 UniProt (SwissProt) Secondary ID(s) of Target Chain 9 UniProt (SwissProt) Alternative ID(s) of Target Chain 9 UniProt (TrEMBL) Submitted Name of Target Chain 9 UniProt (TrEMBL) Entry Name of Target Chain 9 UniProt (TrEMBL) Primary ID of Target Chain 9 UniProt (TrEMBL) Secondary ID(s) of Target Chain 9 UniProt (TrEMBL) Alternative ID(s) of Target Chain 9 BindingDB Target Chain Sequence 10 PDB ID(s) of Target Chain 10 UniProt (SwissProt) Recommended Name of Target Chain 10 UniProt (SwissProt) Entry Name of Target Chain 10 UniProt (SwissProt) Primary ID of Target Chain 10 UniProt (SwissProt) Secondary ID(s) of Target Chain 10 UniProt (SwissProt) Alternative ID(s) of Target Chain 10 UniProt (TrEMBL) Submitted Name of Target Chain 10 UniProt (TrEMBL) Entry Name of Target Chain 10 UniProt (TrEMBL) Primary ID of Target Chain 10 UniProt (TrEMBL) Secondary ID(s) of Target Chain 10 UniProt (TrEMBL) Alternative ID(s) of Target Chain 10 BindingDB Target Chain Sequence 11 PDB ID(s) of Target Chain 11 UniProt (SwissProt) Recommended Name of Target Chain 11 UniProt (SwissProt) Entry Name of Target Chain 11 UniProt (SwissProt) Primary ID of Target Chain 11 UniProt (SwissProt) Secondary ID(s) of Target Chain 11 UniProt (SwissProt) Alternative ID(s) of Target Chain 11 UniProt (TrEMBL) Submitted Name of Target Chain 11 UniProt (TrEMBL) Entry Name of Target Chain 11 UniProt (TrEMBL) Primary ID of Target Chain 11 UniProt (TrEMBL) Secondary ID(s) of Target Chain 11 UniProt (TrEMBL) Alternative ID(s) of Target Chain 11 BindingDB Target Chain Sequence 12 PDB ID(s) of Target Chain 12 UniProt (SwissProt) Recommended Name of Target Chain 12 UniProt (SwissProt) Entry Name of Target Chain 12 UniProt (SwissProt) Primary ID of Target Chain 12 UniProt (SwissProt) Secondary ID(s) of Target Chain 12 UniProt (SwissProt) Alternative ID(s) of Target Chain 12 UniProt (TrEMBL) Submitted Name of Target Chain 12 UniProt (TrEMBL) Entry Name of Target Chain 12 UniProt (TrEMBL) Primary ID of Target Chain 12 UniProt (TrEMBL) Secondary ID(s) of Target Chain 12 UniProt (TrEMBL) Alternative ID(s) of Target Chain 12 BindingDB Target Chain Sequence 13 PDB ID(s) of Target Chain 13 UniProt (SwissProt) Recommended Name of Target Chain 13 UniProt (SwissProt) Entry Name of Target Chain 13 UniProt (SwissProt) Primary ID of Target Chain 13 UniProt (SwissProt) Secondary ID(s) of Target Chain 13 UniProt (SwissProt) Alternative ID(s) of Target Chain 13 UniProt (TrEMBL) Submitted Name of Target Chain 13 UniProt (TrEMBL) Entry Name of Target Chain 13 UniProt (TrEMBL) Primary ID of Target Chain 13 UniProt (TrEMBL) Secondary ID(s) of Target Chain 13 UniProt (TrEMBL) Alternative ID(s) of Target Chain 13 BindingDB Target Chain Sequence 14 PDB ID(s) of Target Chain 14 UniProt (SwissProt) Recommended Name of Target Chain 14 UniProt (SwissProt) Entry Name of Target Chain 14 UniProt (SwissProt) Primary ID of Target Chain 14 UniProt (SwissProt) Secondary ID(s) of Target Chain 14 UniProt (SwissProt) Alternative ID(s) of Target Chain 14 UniProt (TrEMBL) Submitted Name of Target Chain 14 UniProt (TrEMBL) Entry Name of Target Chain 14 UniProt (TrEMBL) Primary ID of Target Chain 14 UniProt (TrEMBL) Secondary ID(s) of Target Chain 14 UniProt (TrEMBL) Alternative ID(s) of Target Chain 14 BindingDB Target Chain Sequence 15 PDB ID(s) of Target Chain 15 UniProt (SwissProt) Recommended Name of Target Chain 15 UniProt (SwissProt) Entry Name of Target Chain 15 UniProt (SwissProt) Primary ID of Target Chain 15 UniProt (SwissProt) Secondary ID(s) of Target Chain 15 UniProt (SwissProt) Alternative ID(s) of Target Chain 15 UniProt (TrEMBL) Submitted Name of Target Chain 15 UniProt (TrEMBL) Entry Name of Target Chain 15 UniProt (TrEMBL) Primary ID of Target Chain 15 UniProt (TrEMBL) Secondary ID(s) of Target Chain 15 UniProt (TrEMBL) Alternative ID(s) of Target Chain 15 BindingDB Target Chain Sequence 16 PDB ID(s) of Target Chain 16 UniProt (SwissProt) Recommended Name of Target Chain 16 UniProt (SwissProt) Entry Name of Target Chain 16 UniProt (SwissProt) Primary ID of Target Chain 16 UniProt (SwissProt) Secondary ID(s) of Target Chain 16 UniProt (SwissProt) Alternative ID(s) of Target Chain 16 UniProt (TrEMBL) Submitted Name of Target Chain 16 UniProt (TrEMBL) Entry Name of Target Chain 16 UniProt (TrEMBL) Primary ID of Target Chain 16 UniProt (TrEMBL) Secondary ID(s) of Target Chain 16 UniProt (TrEMBL) Alternative ID(s) of Target Chain 16 BindingDB Target Chain Sequence 17 PDB ID(s) of Target Chain 17 UniProt (SwissProt) Recommended Name of Target Chain 17 UniProt (SwissProt) Entry Name of Target Chain 17 UniProt (SwissProt) Primary ID of Target Chain 17 UniProt (SwissProt) Secondary ID(s) of Target Chain 17 UniProt (SwissProt) Alternative ID(s) of Target Chain 17 UniProt (TrEMBL) Submitted Name of Target Chain 17 UniProt (TrEMBL) Entry Name of Target Chain 17 UniProt (TrEMBL) Primary ID of Target Chain 17 UniProt (TrEMBL) Secondary ID(s) of Target Chain 17 UniProt (TrEMBL) Alternative ID(s) of Target Chain 17 BindingDB Target Chain Sequence 18 PDB ID(s) of Target Chain 18 UniProt (SwissProt) Recommended Name of Target Chain 18 UniProt (SwissProt) Entry Name of Target Chain 18 UniProt (SwissProt) Primary ID of Target Chain 18 UniProt (SwissProt) Secondary ID(s) of Target Chain 18 UniProt (SwissProt) Alternative ID(s) of Target Chain 18 UniProt (TrEMBL) Submitted Name of Target Chain 18 UniProt (TrEMBL) Entry Name of Target Chain 18 UniProt (TrEMBL) Primary ID of Target Chain 18 UniProt (TrEMBL) Secondary ID(s) of Target Chain 18 UniProt (TrEMBL) Alternative ID(s) of Target Chain 18 BindingDB Target Chain Sequence 19 PDB ID(s) of Target Chain 19 UniProt (SwissProt) Recommended Name of Target Chain 19 UniProt (SwissProt) Entry Name of Target Chain 19 UniProt (SwissProt) Primary ID of Target Chain 19 UniProt (SwissProt) Secondary ID(s) of Target Chain 19 UniProt (SwissProt) Alternative ID(s) of Target Chain 19 UniProt (TrEMBL) Submitted Name of Target Chain 19 UniProt (TrEMBL) Entry Name of Target Chain 19 UniProt (TrEMBL) Primary ID of Target Chain 19 UniProt (TrEMBL) Secondary ID(s) of Target Chain 19 UniProt (TrEMBL) Alternative ID(s) of Target Chain 19 BindingDB Target Chain Sequence 20 PDB ID(s) of Target Chain 20 UniProt (SwissProt) Recommended Name of Target Chain 20 UniProt (SwissProt) Entry Name of Target Chain 20 UniProt (SwissProt) Primary ID of Target Chain 20 UniProt (SwissProt) Secondary ID(s) of Target Chain 20 UniProt (SwissProt) Alternative ID(s) of Target Chain 20 UniProt (TrEMBL) Submitted Name of Target Chain 20 UniProt (TrEMBL) Entry Name of Target Chain 20 UniProt (TrEMBL) Primary ID of Target Chain 20 UniProt (TrEMBL) Secondary ID(s) of Target Chain 20 UniProt (TrEMBL) Alternative ID(s) of Target Chain 20 BindingDB Target Chain Sequence 21 PDB ID(s) of Target Chain 21 UniProt (SwissProt) Recommended Name of Target Chain 21 UniProt (SwissProt) Entry Name of Target Chain 21 UniProt (SwissProt) Primary ID of Target Chain 21 UniProt (SwissProt) Secondary ID(s) of Target Chain 21 UniProt (SwissProt) Alternative ID(s) of Target Chain 21 UniProt (TrEMBL) Submitted Name of Target Chain 21 UniProt (TrEMBL) Entry Name of Target Chain 21 UniProt (TrEMBL) Primary ID of Target Chain 21 UniProt (TrEMBL) Secondary ID(s) of Target Chain 21 UniProt (TrEMBL) Alternative ID(s) of Target Chain 21 BindingDB Target Chain Sequence 22 PDB ID(s) of Target Chain 22 UniProt (SwissProt) Recommended Name of Target Chain 22 UniProt (SwissProt) Entry Name of Target Chain 22 UniProt (SwissProt) Primary ID of Target Chain 22 UniProt (SwissProt) Secondary ID(s) of Target Chain 22 UniProt (SwissProt) Alternative ID(s) of Target Chain 22 UniProt (TrEMBL) Submitted Name of Target Chain 22 UniProt (TrEMBL) Entry Name of Target Chain 22 UniProt (TrEMBL) Primary ID of Target Chain 22 UniProt (TrEMBL) Secondary ID(s) of Target Chain 22 UniProt (TrEMBL) Alternative ID(s) of Target Chain 22 BindingDB Target Chain Sequence 23 PDB ID(s) of Target Chain 23 UniProt (SwissProt) Recommended Name of Target Chain 23 UniProt (SwissProt) Entry Name of Target Chain 23 UniProt (SwissProt) Primary ID of Target Chain 23 UniProt (SwissProt) Secondary ID(s) of Target Chain 23 UniProt (SwissProt) Alternative ID(s) of Target Chain 23 UniProt (TrEMBL) Submitted Name of Target Chain 23 UniProt (TrEMBL) Entry Name of Target Chain 23 UniProt (TrEMBL) Primary ID of Target Chain 23 UniProt (TrEMBL) Secondary ID(s) of Target Chain 23 UniProt (TrEMBL) Alternative ID(s) of Target Chain 23 BindingDB Target Chain Sequence 24 PDB ID(s) of Target Chain 24 UniProt (SwissProt) Recommended Name of Target Chain 24 UniProt (SwissProt) Entry Name of Target Chain 24 UniProt (SwissProt) Primary ID of Target Chain 24 UniProt (SwissProt) Secondary ID(s) of Target Chain 24 UniProt (SwissProt) Alternative ID(s) of Target Chain 24 UniProt (TrEMBL) Submitted Name of Target Chain 24 UniProt (TrEMBL) Entry Name of Target Chain 24 UniProt (TrEMBL) Primary ID of Target Chain 24 UniProt (TrEMBL) Secondary ID(s) of Target Chain 24 UniProt (TrEMBL) Alternative ID(s) of Target Chain 24 BindingDB Target Chain Sequence 25 PDB ID(s) of Target Chain 25 UniProt (SwissProt) Recommended Name of Target Chain 25 UniProt (SwissProt) Entry Name of Target Chain 25 UniProt (SwissProt) Primary ID of Target Chain 25 UniProt (SwissProt) Secondary ID(s) of Target Chain 25 UniProt (SwissProt) Alternative ID(s) of Target Chain 25 UniProt (TrEMBL) Submitted Name of Target Chain 25 UniProt (TrEMBL) Entry Name of Target Chain 25 UniProt (TrEMBL) Primary ID of Target Chain 25 UniProt (TrEMBL) Secondary ID(s) of Target Chain 25 UniProt (TrEMBL) Alternative ID(s) of Target Chain 25 BindingDB Target Chain Sequence 26 PDB ID(s) of Target Chain 26 UniProt (SwissProt) Recommended Name of Target Chain 26 UniProt (SwissProt) Entry Name of Target Chain 26 UniProt (SwissProt) Primary ID of Target Chain 26 UniProt (SwissProt) Secondary ID(s) of Target Chain 26 UniProt (SwissProt) Alternative ID(s) of Target Chain 26 UniProt (TrEMBL) Submitted Name of Target Chain 26 UniProt (TrEMBL) Entry Name of Target Chain 26 UniProt (TrEMBL) Primary ID of Target Chain 26 UniProt (TrEMBL) Secondary ID(s) of Target Chain 26 UniProt (TrEMBL) Alternative ID(s) of Target Chain 26 BindingDB Target Chain Sequence 27 PDB ID(s) of Target Chain 27 UniProt (SwissProt) Recommended Name of Target Chain 27 UniProt (SwissProt) Entry Name of Target Chain 27 UniProt (SwissProt) Primary ID of Target Chain 27 UniProt (SwissProt) Secondary ID(s) of Target Chain 27 UniProt (SwissProt) Alternative ID(s) of Target Chain 27 UniProt (TrEMBL) Submitted Name of Target Chain 27 UniProt (TrEMBL) Entry Name of Target Chain 27 UniProt (TrEMBL) Primary ID of Target Chain 27 UniProt (TrEMBL) Secondary ID(s) of Target Chain 27 UniProt (TrEMBL) Alternative ID(s) of Target Chain 27 BindingDB Target Chain Sequence 28 PDB ID(s) of Target Chain 28 UniProt (SwissProt) Recommended Name of Target Chain 28 UniProt (SwissProt) Entry Name of Target Chain 28 UniProt (SwissProt) Primary ID of Target Chain 28 UniProt (SwissProt) Secondary ID(s) of Target Chain 28 UniProt (SwissProt) Alternative ID(s) of Target Chain 28 UniProt (TrEMBL) Submitted Name of Target Chain 28 UniProt (TrEMBL) Entry Name of Target Chain 28 UniProt (TrEMBL) Primary ID of Target Chain 28 UniProt (TrEMBL) Secondary ID(s) of Target Chain 28 UniProt (TrEMBL) Alternative ID(s) of Target Chain 28 BindingDB Target Chain Sequence 29 PDB ID(s) of Target Chain 29 UniProt (SwissProt) Recommended Name of Target Chain 29 UniProt (SwissProt) Entry Name of Target Chain 29 UniProt (SwissProt) Primary ID of Target Chain 29 UniProt (SwissProt) Secondary ID(s) of Target Chain 29 UniProt (SwissProt) Alternative ID(s) of Target Chain 29 UniProt (TrEMBL) Submitted Name of Target Chain 29 UniProt (TrEMBL) Entry Name of Target Chain 29 UniProt (TrEMBL) Primary ID of Target Chain 29 UniProt (TrEMBL) Secondary ID(s) of Target Chain 29 UniProt (TrEMBL) Alternative ID(s) of Target Chain 29 BindingDB Target Chain Sequence 30 PDB ID(s) of Target Chain 30 UniProt (SwissProt) Recommended Name of Target Chain 30 UniProt (SwissProt) Entry Name of Target Chain 30 UniProt (SwissProt) Primary ID of Target Chain 30 UniProt (SwissProt) Secondary ID(s) of Target Chain 30 UniProt (SwissProt) Alternative ID(s) of Target Chain 30 UniProt (TrEMBL) Submitted Name of Target Chain 30 UniProt (TrEMBL) Entry Name of Target Chain 30 UniProt (TrEMBL) Primary ID of Target Chain 30 UniProt (TrEMBL) Secondary ID(s) of Target Chain 30 UniProt (TrEMBL) Alternative ID(s) of Target Chain 30 BindingDB Target Chain Sequence 31 PDB ID(s) of Target Chain 31 UniProt (SwissProt) Recommended Name of Target Chain 31 UniProt (SwissProt) Entry Name of Target Chain 31 UniProt (SwissProt) Primary ID of Target Chain 31 UniProt (SwissProt) Secondary ID(s) of Target Chain 31 UniProt (SwissProt) Alternative ID(s) of Target Chain 31 UniProt (TrEMBL) Submitted Name of Target Chain 31 UniProt (TrEMBL) Entry Name of Target Chain 31 UniProt (TrEMBL) Primary ID of Target Chain 31 UniProt (TrEMBL) Secondary ID(s) of Target Chain 31 UniProt (TrEMBL) Alternative ID(s) of Target Chain 31 BindingDB Target Chain Sequence 32 PDB ID(s) of Target Chain 32 UniProt (SwissProt) Recommended Name of Target Chain 32 UniProt (SwissProt) Entry Name of Target Chain 32 UniProt (SwissProt) Primary ID of Target Chain 32 UniProt (SwissProt) Secondary ID(s) of Target Chain 32 UniProt (SwissProt) Alternative ID(s) of Target Chain 32 UniProt (TrEMBL) Submitted Name of Target Chain 32 UniProt (TrEMBL) Entry Name of Target Chain 32 UniProt (TrEMBL) Primary ID of Target Chain 32 UniProt (TrEMBL) Secondary ID(s) of Target Chain 32 UniProt (TrEMBL) Alternative ID(s) of Target Chain 32 BindingDB Target Chain Sequence 33 PDB ID(s) of Target Chain 33 UniProt (SwissProt) Recommended Name of Target Chain 33 UniProt (SwissProt) Entry Name of Target Chain 33 UniProt (SwissProt) Primary ID of Target Chain 33 UniProt (SwissProt) Secondary ID(s) of Target Chain 33 UniProt (SwissProt) Alternative ID(s) of Target Chain 33 UniProt (TrEMBL) Submitted Name of Target Chain 33 UniProt (TrEMBL) Entry Name of Target Chain 33 UniProt (TrEMBL) Primary ID of Target Chain 33 UniProt (TrEMBL) Secondary ID(s) of Target Chain 33 UniProt (TrEMBL) Alternative ID(s) of Target Chain 33 BindingDB Target Chain Sequence 34 PDB ID(s) of Target Chain 34 UniProt (SwissProt) Recommended Name of Target Chain 34 UniProt (SwissProt) Entry Name of Target Chain 34 UniProt (SwissProt) Primary ID of Target Chain 34 UniProt (SwissProt) Secondary ID(s) of Target Chain 34 UniProt (SwissProt) Alternative ID(s) of Target Chain 34 UniProt (TrEMBL) Submitted Name of Target Chain 34 UniProt (TrEMBL) Entry Name of Target Chain 34 UniProt (TrEMBL) Primary ID of Target Chain 34 UniProt (TrEMBL) Secondary ID(s) of Target Chain 34 UniProt (TrEMBL) Alternative ID(s) of Target Chain 34 BindingDB Target Chain Sequence 35 PDB ID(s) of Target Chain 35 UniProt (SwissProt) Recommended Name of Target Chain 35 UniProt (SwissProt) Entry Name of Target Chain 35 UniProt (SwissProt) Primary ID of Target Chain 35 UniProt (SwissProt) Secondary ID(s) of Target Chain 35 UniProt (SwissProt) Alternative ID(s) of Target Chain 35 UniProt (TrEMBL) Submitted Name of Target Chain 35 UniProt (TrEMBL) Entry Name of Target Chain 35 UniProt (TrEMBL) Primary ID of Target Chain 35 UniProt (TrEMBL) Secondary ID(s) of Target Chain 35 UniProt (TrEMBL) Alternative ID(s) of Target Chain 35 BindingDB Target Chain Sequence 36 PDB ID(s) of Target Chain 36 UniProt (SwissProt) Recommended Name of Target Chain 36 UniProt (SwissProt) Entry Name of Target Chain 36 UniProt (SwissProt) Primary ID of Target Chain 36 UniProt (SwissProt) Secondary ID(s) of Target Chain 36 UniProt (SwissProt) Alternative ID(s) of Target Chain 36 UniProt (TrEMBL) Submitted Name of Target Chain 36 UniProt (TrEMBL) Entry Name of Target Chain 36 UniProt (TrEMBL) Primary ID of Target Chain 36 UniProt (TrEMBL) Secondary ID(s) of Target Chain 36 UniProt (TrEMBL) Alternative ID(s) of Target Chain 36 BindingDB Target Chain Sequence 37 PDB ID(s) of Target Chain 37 UniProt (SwissProt) Recommended Name of Target Chain 37 UniProt (SwissProt) Entry Name of Target Chain 37 UniProt (SwissProt) Primary ID of Target Chain 37 UniProt (SwissProt) Secondary ID(s) of Target Chain 37 UniProt (SwissProt) Alternative ID(s) of Target Chain 37 UniProt (TrEMBL) Submitted Name of Target Chain 37 UniProt (TrEMBL) Entry Name of Target Chain 37 UniProt (TrEMBL) Primary ID of Target Chain 37 UniProt (TrEMBL) Secondary ID(s) of Target Chain 37 UniProt (TrEMBL) Alternative ID(s) of Target Chain 37 BindingDB Target Chain Sequence 38 PDB ID(s) of Target Chain 38 UniProt (SwissProt) Recommended Name of Target Chain 38 UniProt (SwissProt) Entry Name of Target Chain 38 UniProt (SwissProt) Primary ID of Target Chain 38 UniProt (SwissProt) Secondary ID(s) of Target Chain 38 UniProt (SwissProt) Alternative ID(s) of Target Chain 38 UniProt (TrEMBL) Submitted Name of Target Chain 38 UniProt (TrEMBL) Entry Name of Target Chain 38 UniProt (TrEMBL) Primary ID of Target Chain 38 UniProt (TrEMBL) Secondary ID(s) of Target Chain 38 UniProt (TrEMBL) Alternative ID(s) of Target Chain 38 BindingDB Target Chain Sequence 39 PDB ID(s) of Target Chain 39 UniProt (SwissProt) Recommended Name of Target Chain 39 UniProt (SwissProt) Entry Name of Target Chain 39 UniProt (SwissProt) Primary ID of Target Chain 39 UniProt (SwissProt) Secondary ID(s) of Target Chain 39 UniProt (SwissProt) Alternative ID(s) of Target Chain 39 UniProt (TrEMBL) Submitted Name of Target Chain 39 UniProt (TrEMBL) Entry Name of Target Chain 39 UniProt (TrEMBL) Primary ID of Target Chain 39 UniProt (TrEMBL) Secondary ID(s) of Target Chain 39 UniProt (TrEMBL) Alternative ID(s) of Target Chain 39 BindingDB Target Chain Sequence 40 PDB ID(s) of Target Chain 40 UniProt (SwissProt) Recommended Name of Target Chain 40 UniProt (SwissProt) Entry Name of Target Chain 40 UniProt (SwissProt) Primary ID of Target Chain 40 UniProt (SwissProt) Secondary ID(s) of Target Chain 40 UniProt (SwissProt) Alternative ID(s) of Target Chain 40 UniProt (TrEMBL) Submitted Name of Target Chain 40 UniProt (TrEMBL) Entry Name of Target Chain 40 UniProt (TrEMBL) Primary ID of Target Chain 40 UniProt (TrEMBL) Secondary ID(s) of Target Chain 40 UniProt (TrEMBL) Alternative ID(s) of Target Chain 40 BindingDB Target Chain Sequence 41 PDB ID(s) of Target Chain 41 UniProt (SwissProt) Recommended Name of Target Chain 41 UniProt (SwissProt) Entry Name of Target Chain 41 UniProt (SwissProt) Primary ID of Target Chain 41 UniProt (SwissProt) Secondary ID(s) of Target Chain 41 UniProt (SwissProt) Alternative ID(s) of Target Chain 41 UniProt (TrEMBL) Submitted Name of Target Chain 41 UniProt (TrEMBL) Entry Name of Target Chain 41 UniProt (TrEMBL) Primary ID of Target Chain 41 UniProt (TrEMBL) Secondary ID(s) of Target Chain 41 UniProt (TrEMBL) Alternative ID(s) of Target Chain 41 BindingDB Target Chain Sequence 42 PDB ID(s) of Target Chain 42 UniProt (SwissProt) Recommended Name of Target Chain 42 UniProt (SwissProt) Entry Name of Target Chain 42 UniProt (SwissProt) Primary ID of Target Chain 42 UniProt (SwissProt) Secondary ID(s) of Target Chain 42 UniProt (SwissProt) Alternative ID(s) of Target Chain 42 UniProt (TrEMBL) Submitted Name of Target Chain 42 UniProt (TrEMBL) Entry Name of Target Chain 42 UniProt (TrEMBL) Primary ID of Target Chain 42 UniProt (TrEMBL) Secondary ID(s) of Target Chain 42 UniProt (TrEMBL) Alternative ID(s) of Target Chain 42 BindingDB Target Chain Sequence 43 PDB ID(s) of Target Chain 43 UniProt (SwissProt) Recommended Name of Target Chain 43 UniProt (SwissProt) Entry Name of Target Chain 43 UniProt (SwissProt) Primary ID of Target Chain 43 UniProt (SwissProt) Secondary ID(s) of Target Chain 43 UniProt (SwissProt) Alternative ID(s) of Target Chain 43 UniProt (TrEMBL) Submitted Name of Target Chain 43 UniProt (TrEMBL) Entry Name of Target Chain 43 UniProt (TrEMBL) Primary ID of Target Chain 43 UniProt (TrEMBL) Secondary ID(s) of Target Chain 43 UniProt (TrEMBL) Alternative ID(s) of Target Chain 43 BindingDB Target Chain Sequence 44 PDB ID(s) of Target Chain 44 UniProt (SwissProt) Recommended Name of Target Chain 44 UniProt (SwissProt) Entry Name of Target Chain 44 UniProt (SwissProt) Primary ID of Target Chain 44 UniProt (SwissProt) Secondary ID(s) of Target Chain 44 UniProt (SwissProt) Alternative ID(s) of Target Chain 44 UniProt (TrEMBL) Submitted Name of Target Chain 44 UniProt (TrEMBL) Entry Name of Target Chain 44 UniProt (TrEMBL) Primary ID of Target Chain 44 UniProt (TrEMBL) Secondary ID(s) of Target Chain 44 UniProt (TrEMBL) Alternative ID(s) of Target Chain 44 BindingDB Target Chain Sequence 45 PDB ID(s) of Target Chain 45 UniProt (SwissProt) Recommended Name of Target Chain 45 UniProt (SwissProt) Entry Name of Target Chain 45 UniProt (SwissProt) Primary ID of Target Chain 45 UniProt (SwissProt) Secondary ID(s) of Target Chain 45 UniProt (SwissProt) Alternative ID(s) of Target Chain 45 UniProt (TrEMBL) Submitted Name of Target Chain 45 UniProt (TrEMBL) Entry Name of Target Chain 45 UniProt (TrEMBL) Primary ID of Target Chain 45 UniProt (TrEMBL) Secondary ID(s) of Target Chain 45 UniProt (TrEMBL) Alternative ID(s) of Target Chain 45 BindingDB Target Chain Sequence 46 PDB ID(s) of Target Chain 46 UniProt (SwissProt) Recommended Name of Target Chain 46 UniProt (SwissProt) Entry Name of Target Chain 46 UniProt (SwissProt) Primary ID of Target Chain 46 UniProt (SwissProt) Secondary ID(s) of Target Chain 46 UniProt (SwissProt) Alternative ID(s) of Target Chain 46 UniProt (TrEMBL) Submitted Name of Target Chain 46 UniProt (TrEMBL) Entry Name of Target Chain 46 UniProt (TrEMBL) Primary ID of Target Chain 46 UniProt (TrEMBL) Secondary ID(s) of Target Chain 46 UniProt (TrEMBL) Alternative ID(s) of Target Chain 46 BindingDB Target Chain Sequence 47 PDB ID(s) of Target Chain 47 UniProt (SwissProt) Recommended Name of Target Chain 47 UniProt (SwissProt) Entry Name of Target Chain 47 UniProt (SwissProt) Primary ID of Target Chain 47 UniProt (SwissProt) Secondary ID(s) of Target Chain 47 UniProt (SwissProt) Alternative ID(s) of Target Chain 47 UniProt (TrEMBL) Submitted Name of Target Chain 47 UniProt (TrEMBL) Entry Name of Target Chain 47 UniProt (TrEMBL) Primary ID of Target Chain 47 UniProt (TrEMBL) Secondary ID(s) of Target Chain 47 UniProt (TrEMBL) Alternative ID(s) of Target Chain 47 BindingDB Target Chain Sequence 48 PDB ID(s) of Target Chain 48 UniProt (SwissProt) Recommended Name of Target Chain 48 UniProt (SwissProt) Entry Name of Target Chain 48 UniProt (SwissProt) Primary ID of Target Chain 48 UniProt (SwissProt) Secondary ID(s) of Target Chain 48 UniProt (SwissProt) Alternative ID(s) of Target Chain 48 UniProt (TrEMBL) Submitted Name of Target Chain 48 UniProt (TrEMBL) Entry Name of Target Chain 48 UniProt (TrEMBL) Primary ID of Target Chain 48 UniProt (TrEMBL) Secondary ID(s) of Target Chain 48 UniProt (TrEMBL) Alternative ID(s) of Target Chain 48 BindingDB Target Chain Sequence 49 PDB ID(s) of Target Chain 49 UniProt (SwissProt) Recommended Name of Target Chain 49 UniProt (SwissProt) Entry Name of Target Chain 49 UniProt (SwissProt) Primary ID of Target Chain 49 UniProt (SwissProt) Secondary ID(s) of Target Chain 49 UniProt (SwissProt) Alternative ID(s) of Target Chain 49 UniProt (TrEMBL) Submitted Name of Target Chain 49 UniProt (TrEMBL) Entry Name of Target Chain 49 UniProt (TrEMBL) Primary ID of Target Chain 49 UniProt (TrEMBL) Secondary ID(s) of Target Chain 49 UniProt (TrEMBL) Alternative ID(s) of Target Chain 49 BindingDB Target Chain Sequence 50 PDB ID(s) of Target Chain 50 UniProt (SwissProt) Recommended Name of Target Chain 50 UniProt (SwissProt) Entry Name of Target Chain 50 UniProt (SwissProt) Primary ID of Target Chain 50 UniProt (SwissProt) Secondary ID(s) of Target Chain 50 UniProt (SwissProt) Alternative ID(s) of Target Chain 50 UniProt (TrEMBL) Submitted Name of Target Chain 50 UniProt (TrEMBL) Entry Name of Target Chain 50 UniProt (TrEMBL) Primary ID of Target Chain 50 UniProt (TrEMBL) Secondary ID(s) of Target Chain 50 UniProt (TrEMBL) Alternative ID(s) of Target Chain 50 714956 Cn1cc2c(cccc2n1)-c1cc(F)c(CN2Cc3ccc4nncn4c3C2=O)c(F)c1 InChI=1S/C23H16F2N6O/c1-29-10-16-15(3-2-4-20(16)28-29)14-7-18(24)17(19(25)8-14)11-30-9-13-5-6-21-27-26-12-31(21)22(13)23(30)32/h2-8,10,12H,9,11H2,1H3 ZRHCCDRZGHEJQH-UHFFFAOYSA-N 361596 A. Preparation of 7-(2,6-difluoro-4-(2-methyl-2h-indazol-4-yl)benzyl)-6,7-dihydro-8H-pyrrolo[3,4-e][1,2,4]triazolo [4,3-a]pyridin-8-one ::US10221175, Compound 1 Muscarinic acetylcholine receptor M1 Human 952 US Patent 10.7270/Q27W6FGP aid1797849 US10221175 Conn, PJ; Lindsley, CW; Emmitte, KA; Han, C; Engers, JL; Bender, AM 3/5/2019 10/27/2019 Vanderbilt University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361596 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10062&target=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361596&enzyme=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search 122648623 386400976 1 MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC Muscarinic acetylcholine receptor M1 ACM1_HUMAN P11229 Q96RH1 714957 Cn1cc2c(cccc2n1)-c1ccc(CN2Cc3ccc4nncn4c3C2=O)c(F)c1 InChI=1S/C23H17FN6O/c1-28-12-18-17(3-2-4-20(18)27-28)14-5-6-15(19(24)9-14)10-29-11-16-7-8-21-26-25-13-30(21)22(16)23(29)31/h2-9,12-13H,10-11H2,1H3 ZJGIIVFLFPSDOY-UHFFFAOYSA-N 361597 A. Preparation of 7-(2-fluoro-4-(2-methyl-2H-indazol-4-yl)benzyl)-6,7-dihydro-8H-pyrrolo [3,4-e][1,2,4]triazol[4,3-a]pyridin-8-one ::US10221175, Compound 2 Muscarinic acetylcholine receptor M1 Human 688 US Patent 10.7270/Q27W6FGP aid1797849 US10221175 Conn, PJ; Lindsley, CW; Emmitte, KA; Han, C; Engers, JL; Bender, AM 3/5/2019 10/27/2019 Vanderbilt University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361597 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10062&target=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361597&enzyme=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search 122648637 386400977 1 MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC Muscarinic acetylcholine receptor M1 ACM1_HUMAN P11229 Q96RH1 714958 Cn1cc(cn1)-c1cc(F)c(CN2Cc3ccc4nncn4c3C2=O)c(F)c1 InChI=1S/C19H14F2N6O/c1-25-7-13(6-23-25)12-4-15(20)14(16(21)5-12)9-26-8-11-2-3-17-24-22-10-27(17)18(11)19(26)28/h2-7,10H,8-9H2,1H3 QYKXSHMMOHMBJP-UHFFFAOYSA-N 361598 US10221175, Compound 3 Muscarinic acetylcholine receptor M1 Human 656 US Patent 10.7270/Q27W6FGP aid1797849 US10221175 Conn, PJ; Lindsley, CW; Emmitte, KA; Han, C; Engers, JL; Bender, AM 3/5/2019 10/27/2019 Vanderbilt University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361598 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10062&target=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361598&enzyme=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search 122648634 386400978 1 MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC Muscarinic acetylcholine receptor M1 ACM1_HUMAN P11229 Q96RH1 714959 Fc1cc(ccc1CN1Cc2ccc3nncn3c2C1=O)-c1cnc2ccccc2c1 InChI=1S/C24H16FN5O/c25-20-10-15(19-9-16-3-1-2-4-21(16)26-11-19)5-6-17(20)12-29-13-18-7-8-22-28-27-14-30(22)23(18)24(29)31/h1-11,14H,12-13H2 QTZRGDANTYGZJU-UHFFFAOYSA-N 361599 US10221175, Compound 4 Muscarinic acetylcholine receptor M1 Human 1750 US Patent 10.7270/Q27W6FGP aid1797849 US10221175 Conn, PJ; Lindsley, CW; Emmitte, KA; Han, C; Engers, JL; Bender, AM 3/5/2019 10/27/2019 Vanderbilt University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361599 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10062&target=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361599&enzyme=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search 122648633 386400979 1 MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC Muscarinic acetylcholine receptor M1 ACM1_HUMAN P11229 Q96RH1 714960 Fc1cc(cc(F)c1CN1Cc2ccc3nncn3c2C1=O)-c1ccc2ncccc2c1 InChI=1S/C24H15F2N5O/c25-19-9-17(14-3-5-21-15(8-14)2-1-7-27-21)10-20(26)18(19)12-30-11-16-4-6-22-29-28-13-31(22)23(16)24(30)32/h1-10,13H,11-12H2 VXQODDGBWZVNJZ-UHFFFAOYSA-N 361600 US10221175, Compound 5 Muscarinic acetylcholine receptor M1 Human 743 US Patent 10.7270/Q27W6FGP aid1797849 US10221175 Conn, PJ; Lindsley, CW; Emmitte, KA; Han, C; Engers, JL; Bender, AM 3/5/2019 10/27/2019 Vanderbilt University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361600 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10062&target=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361600&enzyme=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search 122648632 386400980 1 MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC Muscarinic acetylcholine receptor M1 ACM1_HUMAN P11229 Q96RH1 714961 Cn1cc2cc(ccc2n1)-c1cc(F)c(CN2Cc3ccc4nncn4c3C2=O)c(F)c1 InChI=1S/C23H16F2N6O/c1-29-9-16-6-13(2-4-20(16)28-29)15-7-18(24)17(19(25)8-15)11-30-10-14-3-5-21-27-26-12-31(21)22(14)23(30)32/h2-9,12H,10-11H2,1H3 JSCCYJFJNWMVBS-UHFFFAOYSA-N 361601 US10221175, Compound 6 Muscarinic acetylcholine receptor M1 Human 488 US Patent 10.7270/Q27W6FGP aid1797849 US10221175 Conn, PJ; Lindsley, CW; Emmitte, KA; Han, C; Engers, JL; Bender, AM 3/5/2019 10/27/2019 Vanderbilt University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361601 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10062&target=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361601&enzyme=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search 122648635 386400981 1 MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC Muscarinic acetylcholine receptor M1 ACM1_HUMAN P11229 Q96RH1 714962 COc1ccc(cn1)-c1cc(F)c(CN2Cc3ccc4nncn4c3C2=O)c(F)c1 InChI=1S/C21H15F2N5O2/c1-30-19-5-3-12(8-24-19)14-6-16(22)15(17(23)7-14)10-27-9-13-2-4-18-26-25-11-28(18)20(13)21(27)29/h2-8,11H,9-10H2,1H3 YZRBNMJLJLQMSZ-UHFFFAOYSA-N 361602 US10221175, Compound 7 Muscarinic acetylcholine receptor M1 Human 2640 US Patent 10.7270/Q27W6FGP aid1797849 US10221175 Conn, PJ; Lindsley, CW; Emmitte, KA; Han, C; Engers, JL; Bender, AM 3/5/2019 10/27/2019 Vanderbilt University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361602 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10062&target=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361602&enzyme=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search 122648636 386400982 1 MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC Muscarinic acetylcholine receptor M1 ACM1_HUMAN P11229 Q96RH1 714963 Cc1ccc(-c2ccc(CN3Cc4ccc5nncn5c4C3=O)c(F)c2)c2cn(C)nc12 InChI=1S/C24H19FN6O/c1-14-3-7-18(19-12-29(2)28-22(14)19)15-4-5-16(20(25)9-15)10-30-11-17-6-8-21-27-26-13-31(21)23(17)24(30)32/h3-9,12-13H,10-11H2,1-2H3 ARMQPARWSPIEHX-UHFFFAOYSA-N 361603 US10221175, Compound 8 Muscarinic acetylcholine receptor M1 Human 1060 US Patent 10.7270/Q27W6FGP aid1797849 US10221175 Conn, PJ; Lindsley, CW; Emmitte, KA; Han, C; Engers, JL; Bender, AM 3/5/2019 10/27/2019 Vanderbilt University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361603 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10062&target=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361603&enzyme=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search 122648689 386400983 1 MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC Muscarinic acetylcholine receptor M1 ACM1_HUMAN P11229 Q96RH1 714964 Cn1cc2cc(ccc2n1)-c1ccc(CN2Cc3ccc4nncn4c3C2=O)c(F)c1 InChI=1S/C23H17FN6O/c1-28-10-18-8-14(4-6-20(18)27-28)15-2-3-16(19(24)9-15)11-29-12-17-5-7-21-26-25-13-30(21)22(17)23(29)31/h2-10,13H,11-12H2,1H3 MJTZHRGINBFCFX-UHFFFAOYSA-N 361604 A. Preparation of 7-(2-fluoro-4-(2-methyl-2H-indazol-5-yl)benzyl)-6,7-dihydro-8H-pyrrolo [3,4-e][1,2,4]triazolo[4,3-a]pyridin-8-one ::US10221175, Compound 9 Muscarinic acetylcholine receptor M1 Human 502 US Patent 10.7270/Q27W6FGP aid1797849 US10221175 Conn, PJ; Lindsley, CW; Emmitte, KA; Han, C; Engers, JL; Bender, AM 3/5/2019 10/27/2019 Vanderbilt University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361604 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10062&target=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361604&enzyme=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search 122648678 386400984 1 MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC Muscarinic acetylcholine receptor M1 ACM1_HUMAN P11229 Q96RH1 714965 Fc1cc(ccc1CN1Cc2ccc3nncn3c2C1=O)-c1ccc2ncccc2c1 InChI=1S/C24H16FN5O/c25-20-11-16(15-5-7-21-17(10-15)2-1-9-26-21)3-4-18(20)12-29-13-19-6-8-22-28-27-14-30(22)23(19)24(29)31/h1-11,14H,12-13H2 QTUORNFGCYKCSO-UHFFFAOYSA-N 361605 US10221175, Compound 10 Muscarinic acetylcholine receptor M1 Human 1570 US Patent 10.7270/Q27W6FGP aid1797849 US10221175 Conn, PJ; Lindsley, CW; Emmitte, KA; Han, C; Engers, JL; Bender, AM 3/5/2019 10/27/2019 Vanderbilt University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361605 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10062&target=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361605&enzyme=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search 122648692 386400985 1 MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC Muscarinic acetylcholine receptor M1 ACM1_HUMAN P11229 Q96RH1 714966 Cn1cc(cn1)-c1ccc(CN2Cc3ccc4nncn4c3C2=O)c(F)c1 InChI=1S/C19H15FN6O/c1-24-8-15(7-22-24)12-2-3-13(16(20)6-12)9-25-10-14-4-5-17-23-21-11-26(17)18(14)19(25)27/h2-8,11H,9-10H2,1H3 QUAZZBAHVZEMBJ-UHFFFAOYSA-N 361606 US10221175, Compound 11 Muscarinic acetylcholine receptor M1 Human 856 US Patent 10.7270/Q27W6FGP aid1797849 US10221175 Conn, PJ; Lindsley, CW; Emmitte, KA; Han, C; Engers, JL; Bender, AM 3/5/2019 10/27/2019 Vanderbilt University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361606 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10062&target=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361606&enzyme=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search 122648690 386400986 1 MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC Muscarinic acetylcholine receptor M1 ACM1_HUMAN P11229 Q96RH1 714967 Fc1cc(ccc1CN1Cc2ccc3nncn3c2C1=O)-n1cccn1 InChI=1S/C18H13FN6O/c19-15-8-14(25-7-1-6-21-25)4-2-12(15)9-23-10-13-3-5-16-22-20-11-24(16)17(13)18(23)26/h1-8,11H,9-10H2 ARIITQGEWUJUPE-UHFFFAOYSA-N 361607 US10221175, Compound 12 Muscarinic acetylcholine receptor M1 Human 30000 US Patent 10.7270/Q27W6FGP aid1797849 US10221175 Conn, PJ; Lindsley, CW; Emmitte, KA; Han, C; Engers, JL; Bender, AM 3/5/2019 10/27/2019 Vanderbilt University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361607 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10062&target=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361607&enzyme=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search 122648675 386400987 1 MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC Muscarinic acetylcholine receptor M1 ACM1_HUMAN P11229 Q96RH1 714968 Fc1cc(cc(F)c1CN1Cc2ccc3nncn3c2C1=O)-c1cnc2ccccc2c1 InChI=1S/C24H15F2N5O/c25-19-8-16(17-7-14-3-1-2-4-21(14)27-10-17)9-20(26)18(19)12-30-11-15-5-6-22-29-28-13-31(22)23(15)24(30)32/h1-10,13H,11-12H2 BTYZIKMWJWFHFB-UHFFFAOYSA-N 361608 US10221175, Compound 13 Muscarinic acetylcholine receptor M1 Human 1820 US Patent 10.7270/Q27W6FGP aid1797849 US10221175 Conn, PJ; Lindsley, CW; Emmitte, KA; Han, C; Engers, JL; Bender, AM 3/5/2019 10/27/2019 Vanderbilt University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361608 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10062&target=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361608&enzyme=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search 122648687 386400988 1 MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC Muscarinic acetylcholine receptor M1 ACM1_HUMAN P11229 Q96RH1 714969 Cc1nnc2ccc3CN(Cc4c(F)cc(cc4F)-c4cnn(C)c4)C(=O)c3n12 InChI=1S/C20H16F2N6O/c1-11-24-25-18-4-3-12-9-27(20(29)19(12)28(11)18)10-15-16(21)5-13(6-17(15)22)14-7-23-26(2)8-14/h3-8H,9-10H2,1-2H3 HCNPXNURVVEPAW-UHFFFAOYSA-N 361609 US10221175, Compound 14 Muscarinic acetylcholine receptor M1 Human 1790 US Patent 10.7270/Q27W6FGP aid1797849 US10221175 Conn, PJ; Lindsley, CW; Emmitte, KA; Han, C; Engers, JL; Bender, AM 3/5/2019 10/27/2019 Vanderbilt University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361609 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10062&target=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361609&enzyme=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search 122648693 386400989 1 MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC Muscarinic acetylcholine receptor M1 ACM1_HUMAN P11229 Q96RH1 714970 Cc1nnc2ccc3CN(Cc4c(F)cc(cc4F)-c4ccc5nn(C)cc5c4)C(=O)c3n12 InChI=1S/C24H18F2N6O/c1-13-27-28-22-6-4-15-11-31(24(33)23(15)32(13)22)12-18-19(25)8-16(9-20(18)26)14-3-5-21-17(7-14)10-30(2)29-21/h3-10H,11-12H2,1-2H3 GBQBSNDJOJRZFR-UHFFFAOYSA-N 361610 US10221175, Compound 15 Muscarinic acetylcholine receptor M1 Human 1240 US Patent 10.7270/Q27W6FGP aid1797849 US10221175 Conn, PJ; Lindsley, CW; Emmitte, KA; Han, C; Engers, JL; Bender, AM 3/5/2019 10/27/2019 Vanderbilt University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361610 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10062&target=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361610&enzyme=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search 122648615 386400990 1 MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC Muscarinic acetylcholine receptor M1 ACM1_HUMAN P11229 Q96RH1 714971 Cc1nnc2ccc3CN(Cc4ccc(cc4F)-c4ccc5nn(C)cc5c4)C(=O)c3n12 InChI=1S/C24H19FN6O/c1-14-26-27-22-8-6-18-13-30(24(32)23(18)31(14)22)12-17-4-3-16(10-20(17)25)15-5-7-21-19(9-15)11-29(2)28-21/h3-11H,12-13H2,1-2H3 BYLGCWTVNXOLIR-UHFFFAOYSA-N 361611 US10221175, Compound 16 Muscarinic acetylcholine receptor M1 Human 1210 US Patent 10.7270/Q27W6FGP aid1797849 US10221175 Conn, PJ; Lindsley, CW; Emmitte, KA; Han, C; Engers, JL; Bender, AM 3/5/2019 10/27/2019 Vanderbilt University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361611 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10062&target=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361611&enzyme=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search 122648691 386400991 1 MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC Muscarinic acetylcholine receptor M1 ACM1_HUMAN P11229 Q96RH1 714972 Cc1cc(cc2cn(C)nc12)-c1ccc(CN2Cc3ccc4nncn4c3C2=O)c(F)c1 InChI=1S/C24H19FN6O/c1-14-7-18(8-19-10-29(2)28-22(14)19)15-3-4-16(20(25)9-15)11-30-12-17-5-6-21-27-26-13-31(21)23(17)24(30)32/h3-10,13H,11-12H2,1-2H3 FJRSQUDXPNWMJE-UHFFFAOYSA-N 361612 US10221175, Compound 17 Muscarinic acetylcholine receptor M1 Human 618 US Patent 10.7270/Q27W6FGP aid1797849 US10221175 Conn, PJ; Lindsley, CW; Emmitte, KA; Han, C; Engers, JL; Bender, AM 3/5/2019 10/27/2019 Vanderbilt University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361612 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10062&target=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361612&enzyme=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search 122648688 386400992 1 MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC Muscarinic acetylcholine receptor M1 ACM1_HUMAN P11229 Q96RH1 714973 Cc1nnc2ccc3CN(Cc4ccc(cc4F)-c4ccc(C)c5nn(C)cc45)C(=O)c3n12 InChI=1S/C25H21FN6O/c1-14-4-8-19(20-13-30(3)29-23(14)20)16-5-6-17(21(26)10-16)11-31-12-18-7-9-22-28-27-15(2)32(22)24(18)25(31)33/h4-10,13H,11-12H2,1-3H3 JWFYRFVFVWYVMV-UHFFFAOYSA-N 361613 US10221175, Compound 18 Muscarinic acetylcholine receptor M1 Human 2140 US Patent 10.7270/Q27W6FGP aid1797849 US10221175 Conn, PJ; Lindsley, CW; Emmitte, KA; Han, C; Engers, JL; Bender, AM 3/5/2019 10/27/2019 Vanderbilt University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361613 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10062&target=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361613&enzyme=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search 122648676 386400993 1 MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC Muscarinic acetylcholine receptor M1 ACM1_HUMAN P11229 Q96RH1 714974 Cc1nnc2ccc3CN(Cc4c(F)cc(cc4F)-c4cccc5nn(C)cc45)C(=O)c3n12 InChI=1S/C24H18F2N6O/c1-13-27-28-22-7-6-14-10-31(24(33)23(14)32(13)22)12-18-19(25)8-15(9-20(18)26)16-4-3-5-21-17(16)11-30(2)29-21/h3-9,11H,10,12H2,1-2H3 OFFWREIIHNVIAR-UHFFFAOYSA-N 361614 US10221175, Compound 19 Muscarinic acetylcholine receptor M1 Human 1410 US Patent 10.7270/Q27W6FGP aid1797849 US10221175 Conn, PJ; Lindsley, CW; Emmitte, KA; Han, C; Engers, JL; Bender, AM 3/5/2019 10/27/2019 Vanderbilt University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361614 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10062&target=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361614&enzyme=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search 122648672 386400994 1 MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC Muscarinic acetylcholine receptor M1 ACM1_HUMAN P11229 Q96RH1 714975 Cc1nnc2ccc3CN(Cc4ccc(cc4F)-c4cc(C)c5nn(C)cc5c4)C(=O)c3n12 InChI=1S/C25H21FN6O/c1-14-8-19(9-20-11-30(3)29-23(14)20)16-4-5-17(21(26)10-16)12-31-13-18-6-7-22-28-27-15(2)32(22)24(18)25(31)33/h4-11H,12-13H2,1-3H3 YWERFIBFEAXCJT-UHFFFAOYSA-N 361615 US10221175, Compound 20 Muscarinic acetylcholine receptor M1 Human 2100 US Patent 10.7270/Q27W6FGP aid1797849 US10221175 Conn, PJ; Lindsley, CW; Emmitte, KA; Han, C; Engers, JL; Bender, AM 3/5/2019 10/27/2019 Vanderbilt University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361615 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10062&target=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361615&enzyme=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search 122648671 386400995 1 MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC Muscarinic acetylcholine receptor M1 ACM1_HUMAN P11229 Q96RH1 714976 Cn1cc(cn1)-c1ccc(F)c(CN2Cc3ccc4nncn4c3C2=O)c1 InChI=1S/C19H15FN6O/c1-24-8-15(7-22-24)12-2-4-16(20)14(6-12)10-25-9-13-3-5-17-23-21-11-26(17)18(13)19(25)27/h2-8,11H,9-10H2,1H3 AEZYFRZPXDUTEL-UHFFFAOYSA-N 361616 US10221175, Compound 21 Muscarinic acetylcholine receptor M1 Human 10000 US Patent 10.7270/Q27W6FGP aid1797849 US10221175 Conn, PJ; Lindsley, CW; Emmitte, KA; Han, C; Engers, JL; Bender, AM 3/5/2019 10/27/2019 Vanderbilt University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361616 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10062&target=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361616&enzyme=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search 122648674 386400996 1 MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC Muscarinic acetylcholine receptor M1 ACM1_HUMAN P11229 Q96RH1 714977 Cn1cc2cc(ccc2n1)-c1ccc(F)c(CN2Cc3ccc4nncn4c3C2=O)c1 InChI=1S/C23H17FN6O/c1-28-10-18-9-15(3-6-20(18)27-28)14-2-5-19(24)17(8-14)12-29-11-16-4-7-21-26-25-13-30(21)22(16)23(29)31/h2-10,13H,11-12H2,1H3 LJASHIRVTFMVJQ-UHFFFAOYSA-N 361617 US10221175, Compound 22 Muscarinic acetylcholine receptor M1 Human 1310 US Patent 10.7270/Q27W6FGP aid1797849 US10221175 Conn, PJ; Lindsley, CW; Emmitte, KA; Han, C; Engers, JL; Bender, AM 3/5/2019 10/27/2019 Vanderbilt University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361617 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10062&target=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361617&enzyme=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search 122648682 386400997 1 MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC Muscarinic acetylcholine receptor M1 ACM1_HUMAN P11229 Q96RH1 714978 Cn1cc2c(cccc2n1)-c1ccc(F)c(CN2Cc3ccc4nncn4c3C2=O)c1 InChI=1S/C23H17FN6O/c1-28-12-18-17(3-2-4-20(18)27-28)14-5-7-19(24)16(9-14)11-29-10-15-6-8-21-26-25-13-30(21)22(15)23(29)31/h2-9,12-13H,10-11H2,1H3 CNIRKPZNTFJRCQ-UHFFFAOYSA-N 361618 US10221175, Compound 23 Muscarinic acetylcholine receptor M1 Human 1350 US Patent 10.7270/Q27W6FGP aid1797849 US10221175 Conn, PJ; Lindsley, CW; Emmitte, KA; Han, C; Engers, JL; Bender, AM 3/5/2019 10/27/2019 Vanderbilt University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361618 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10062&target=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361618&enzyme=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search 122648673 386400998 1 MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC Muscarinic acetylcholine receptor M1 ACM1_HUMAN P11229 Q96RH1 714979 Fc1ccc(cc1CN1Cc2ccc3nncn3c2C1=O)-c1cnc2ccccc2c1 InChI=1S/C24H16FN5O/c25-20-7-5-15(18-10-16-3-1-2-4-21(16)26-11-18)9-19(20)13-29-12-17-6-8-22-28-27-14-30(22)23(17)24(29)31/h1-11,14H,12-13H2 IVNOGAUHHXFADL-UHFFFAOYSA-N 361619 US10221175, Compound 24 Muscarinic acetylcholine receptor M1 Human 30000 US Patent 10.7270/Q27W6FGP aid1797849 US10221175 Conn, PJ; Lindsley, CW; Emmitte, KA; Han, C; Engers, JL; Bender, AM 3/5/2019 10/27/2019 Vanderbilt University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361619 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10062&target=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361619&enzyme=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search 122648679 386400999 1 MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC Muscarinic acetylcholine receptor M1 ACM1_HUMAN P11229 Q96RH1 714980 Fc1ccc(cc1CN1Cc2ccc3nncn3c2C1=O)-c1ccc2ncccc2c1 InChI=1S/C24H16FN5O/c25-20-6-3-15(16-4-7-21-17(10-16)2-1-9-26-21)11-19(20)13-29-12-18-5-8-22-28-27-14-30(22)23(18)24(29)31/h1-11,14H,12-13H2 YFDMOWMKKPPFCD-UHFFFAOYSA-N 361620 US10221175, Compound 25 Muscarinic acetylcholine receptor M1 Human 30000 US Patent 10.7270/Q27W6FGP aid1797849 US10221175 Conn, PJ; Lindsley, CW; Emmitte, KA; Han, C; Engers, JL; Bender, AM 3/5/2019 10/27/2019 Vanderbilt University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361620 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10062&target=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361620&enzyme=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search 122648683 386401000 1 MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC Muscarinic acetylcholine receptor M1 ACM1_HUMAN P11229 Q96RH1 714981 COc1ccc(cn1)-c1ccc(F)c(CN2Cc3ccc4nncn4c3C2=O)c1 InChI=1S/C21H16FN5O2/c1-29-19-7-4-14(9-23-19)13-2-5-17(22)16(8-13)11-26-10-15-3-6-18-25-24-12-27(18)20(15)21(26)28/h2-9,12H,10-11H2,1H3 JNZOTGJGSUWEMR-UHFFFAOYSA-N 361621 US10221175, Compound 26 Muscarinic acetylcholine receptor M1 Human 30000 US Patent 10.7270/Q27W6FGP aid1797849 US10221175 Conn, PJ; Lindsley, CW; Emmitte, KA; Han, C; Engers, JL; Bender, AM 3/5/2019 10/27/2019 Vanderbilt University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361621 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10062&target=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361621&enzyme=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search 122648684 386401001 1 MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC Muscarinic acetylcholine receptor M1 ACM1_HUMAN P11229 Q96RH1 714982 Cn1cc(cn1)-c1ccc(CN2Cc3ccc4nccn4c3C2=O)c(F)c1 InChI=1S/C20H16FN5O/c1-24-10-16(9-23-24)13-2-3-14(17(21)8-13)11-25-12-15-4-5-18-22-6-7-26(18)19(15)20(25)27/h2-10H,11-12H2,1H3 DLXLMGDABMBHNM-UHFFFAOYSA-N 361622 US10221175, Compound 27 Muscarinic acetylcholine receptor M1 Human 2260 US Patent 10.7270/Q27W6FGP aid1797849 US10221175 Conn, PJ; Lindsley, CW; Emmitte, KA; Han, C; Engers, JL; Bender, AM 3/5/2019 10/27/2019 Vanderbilt University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361622 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10062&target=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361622&enzyme=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search 122648680 386401002 1 MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC Muscarinic acetylcholine receptor M1 ACM1_HUMAN P11229 Q96RH1 714983 Cn1cc(cn1)-c1cc(F)c(CN2Cc3ccc4nccn4c3C2=O)c(F)c1 InChI=1S/C20H15F2N5O/c1-25-9-14(8-24-25)13-6-16(21)15(17(22)7-13)11-26-10-12-2-3-18-23-4-5-27(18)19(12)20(26)28/h2-9H,10-11H2,1H3 KDYWJAJJVCZWGL-UHFFFAOYSA-N 361623 US10221175, Compound 28 Muscarinic acetylcholine receptor M1 Human 2370 US Patent 10.7270/Q27W6FGP aid1797849 US10221175 Conn, PJ; Lindsley, CW; Emmitte, KA; Han, C; Engers, JL; Bender, AM 3/5/2019 10/27/2019 Vanderbilt University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361623 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10062&target=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361623&enzyme=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search 122648624 386401003 1 MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC Muscarinic acetylcholine receptor M1 ACM1_HUMAN P11229 Q96RH1 714984 Cc1cn2c3C(=O)N(Cc4c(F)cc(cc4F)-c4cnn(C)c4)Cc3ccc2n1 InChI=1S/C21H17F2N5O/c1-12-8-28-19(25-12)4-3-13-10-27(21(29)20(13)28)11-16-17(22)5-14(6-18(16)23)15-7-24-26(2)9-15/h3-9H,10-11H2,1-2H3 QOZRITGASGPRNG-UHFFFAOYSA-N 361624 US10221175, Compound 29 Muscarinic acetylcholine receptor M1 Human 30000 US Patent 10.7270/Q27W6FGP aid1797849 US10221175 Conn, PJ; Lindsley, CW; Emmitte, KA; Han, C; Engers, JL; Bender, AM 3/5/2019 10/27/2019 Vanderbilt University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361624 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10062&target=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361624&enzyme=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search 122648677 386401004 1 MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC Muscarinic acetylcholine receptor M1 ACM1_HUMAN P11229 Q96RH1 714985 Cn1cc(cn1)-c1ccc(CN2Cc3ccc4ncnn4c3C2=O)c(F)c1 InChI=1S/C19H15FN6O/c1-24-8-15(7-22-24)12-2-3-13(16(20)6-12)9-25-10-14-4-5-17-21-11-23-26(17)18(14)19(25)27/h2-8,11H,9-10H2,1H3 KHCOEMVIFKMOPF-UHFFFAOYSA-N 361625 US10221175, Compound 30 Muscarinic acetylcholine receptor M1 Human 677 US Patent 10.7270/Q27W6FGP aid1797849 US10221175 Conn, PJ; Lindsley, CW; Emmitte, KA; Han, C; Engers, JL; Bender, AM 3/5/2019 10/27/2019 Vanderbilt University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361625 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10062&target=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361625&enzyme=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search 122648610 386401005 1 MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC Muscarinic acetylcholine receptor M1 ACM1_HUMAN P11229 Q96RH1 714986 Cn1cc(cn1)-c1cc(F)c(CN2Cc3ccc4ncnn4c3C2=O)c(F)c1 InChI=1S/C19H14F2N6O/c1-25-7-13(6-23-25)12-4-15(20)14(16(21)5-12)9-26-8-11-2-3-17-22-10-24-27(17)18(11)19(26)28/h2-7,10H,8-9H2,1H3 UIMYNKSWFFCGJK-UHFFFAOYSA-N 361626 US10221175, Compound 31 Muscarinic acetylcholine receptor M1 Human 1630 US Patent 10.7270/Q27W6FGP aid1797849 US10221175 Conn, PJ; Lindsley, CW; Emmitte, KA; Han, C; Engers, JL; Bender, AM 3/5/2019 10/27/2019 Vanderbilt University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361626 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10062&target=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361626&enzyme=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search 122648617 386401006 1 MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC Muscarinic acetylcholine receptor M1 ACM1_HUMAN P11229 Q96RH1 714987 Cn1cc2c(cccc2n1)-c1cc(F)c(CN2Cc3ccc4nccn4c3C2=O)c(F)c1 InChI=1S/C24H17F2N5O/c1-29-12-17-16(3-2-4-21(17)28-29)15-9-19(25)18(20(26)10-15)13-30-11-14-5-6-22-27-7-8-31(22)23(14)24(30)32/h2-10,12H,11,13H2,1H3 KONRPFSVKDAZQU-UHFFFAOYSA-N 361627 US10221175, Compound 32 Muscarinic acetylcholine receptor M1 Human 1400 US Patent 10.7270/Q27W6FGP aid1797849 US10221175 Conn, PJ; Lindsley, CW; Emmitte, KA; Han, C; Engers, JL; Bender, AM 3/5/2019 10/27/2019 Vanderbilt University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361627 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10062&target=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361627&enzyme=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search 122648606 386401007 1 MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC Muscarinic acetylcholine receptor M1 ACM1_HUMAN P11229 Q96RH1 714988 Cn1cc2c(cccc2n1)-c1ccc(CN2Cc3ccc4nccn4c3C2=O)c(F)c1 InChI=1S/C24H18FN5O/c1-28-14-19-18(3-2-4-21(19)27-28)15-5-6-16(20(25)11-15)12-29-13-17-7-8-22-26-9-10-30(22)23(17)24(29)31/h2-11,14H,12-13H2,1H3 XCYPMZSWCQQUFE-UHFFFAOYSA-N 361628 US10221175, Compound 33 Muscarinic acetylcholine receptor M1 Human 2200 US Patent 10.7270/Q27W6FGP aid1797849 US10221175 Conn, PJ; Lindsley, CW; Emmitte, KA; Han, C; Engers, JL; Bender, AM 3/5/2019 10/27/2019 Vanderbilt University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361628 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10062&target=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361628&enzyme=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search 122648616 386401008 1 MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC Muscarinic acetylcholine receptor M1 ACM1_HUMAN P11229 Q96RH1 714989 Cn1cc2cc(ccc2n1)-c1ccc(CN2Cc3ccc4nccn4c3C2=O)c(F)c1 InChI=1S/C24H18FN5O/c1-28-12-19-10-15(4-6-21(19)27-28)16-2-3-17(20(25)11-16)13-29-14-18-5-7-22-26-8-9-30(22)23(18)24(29)31/h2-12H,13-14H2,1H3 GDVYKGBXXFLHPE-UHFFFAOYSA-N 361629 US10221175, Compound 34 Muscarinic acetylcholine receptor M1 Human 3903 US Patent 10.7270/Q27W6FGP aid1797849 US10221175 Conn, PJ; Lindsley, CW; Emmitte, KA; Han, C; Engers, JL; Bender, AM 3/5/2019 10/27/2019 Vanderbilt University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361629 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10062&target=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361629&enzyme=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search 122648613 386401009 1 MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC Muscarinic acetylcholine receptor M1 ACM1_HUMAN P11229 Q96RH1 714990 Cn1cc2cc(ccc2n1)-c1cc(F)c(CN2Cc3ccc4nccn4c3C2=O)c(F)c1 InChI=1S/C24H17F2N5O/c1-29-11-17-8-14(2-4-21(17)28-29)16-9-19(25)18(20(26)10-16)13-30-12-15-3-5-22-27-6-7-31(22)23(15)24(30)32/h2-11H,12-13H2,1H3 XATWVSHRUPJPKL-UHFFFAOYSA-N 361630 US10221175, Compound 35 Muscarinic acetylcholine receptor M1 Human 10000 US Patent 10.7270/Q27W6FGP aid1797849 US10221175 Conn, PJ; Lindsley, CW; Emmitte, KA; Han, C; Engers, JL; Bender, AM 3/5/2019 10/27/2019 Vanderbilt University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361630 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10062&target=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361630&enzyme=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search 122648618 386401010 1 MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC Muscarinic acetylcholine receptor M1 ACM1_HUMAN P11229 Q96RH1 714991 Cc1ccc(CN2Cc3ccc4nccn4c3C2=O)cn1 InChI=1S/C16H14N4O/c1-11-2-3-12(8-18-11)9-19-10-13-4-5-14-17-6-7-20(14)15(13)16(19)21/h2-8H,9-10H2,1H3 OYORWLDBQZZGSD-UHFFFAOYSA-N 361631 US10221175, Compound 36 Muscarinic acetylcholine receptor M1 Human 10000 US Patent 10.7270/Q27W6FGP aid1797849 US10221175 Conn, PJ; Lindsley, CW; Emmitte, KA; Han, C; Engers, JL; Bender, AM 3/5/2019 10/27/2019 Vanderbilt University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361631 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10062&target=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361631&enzyme=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search 122648619 386401011 1 MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC Muscarinic acetylcholine receptor M1 ACM1_HUMAN P11229 Q96RH1 714992 O=C1N(Cc2ccc(nc2)-n2ccnn2)Cc2ccc3nccn3c12 InChI=1S/C17H13N7O/c25-17-16-13(2-4-14-18-5-7-23(14)16)11-22(17)10-12-1-3-15(19-9-12)24-8-6-20-21-24/h1-9H,10-11H2 WJKFTEFHNLBECB-UHFFFAOYSA-N 361632 US10221175, Compound 37 Muscarinic acetylcholine receptor M1 Human 10000 US Patent 10.7270/Q27W6FGP aid1797849 US10221175 Conn, PJ; Lindsley, CW; Emmitte, KA; Han, C; Engers, JL; Bender, AM 3/5/2019 10/27/2019 Vanderbilt University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361632 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10062&target=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361632&enzyme=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search 134463550 386401012 1 MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC Muscarinic acetylcholine receptor M1 ACM1_HUMAN P11229 Q96RH1 714993 O=C1N(Cc2ccc(nc2)N2CCOCC2)Cc2ccc3nccn3c12 InChI=1S/C19H19N5O2/c25-19-18-15(2-4-17-20-5-6-24(17)18)13-23(19)12-14-1-3-16(21-11-14)22-7-9-26-10-8-22/h1-6,11H,7-10,12-13H2 ADEIINHRAWQPGB-UHFFFAOYSA-N 361633 US10221175, Compound 38 Muscarinic acetylcholine receptor M1 Human 10000 US Patent 10.7270/Q27W6FGP aid1797849 US10221175 Conn, PJ; Lindsley, CW; Emmitte, KA; Han, C; Engers, JL; Bender, AM 3/5/2019 10/27/2019 Vanderbilt University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361633 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10062&target=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361633&enzyme=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search 122648614 386401013 1 MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC Muscarinic acetylcholine receptor M1 ACM1_HUMAN P11229 Q96RH1 714994 Fc1cc(cc(F)c1CN1Cc2ccc3nccn3c2C1=O)-c1ccc2ncccc2c1 InChI=1S/C25H16F2N4O/c26-20-11-18(15-3-5-22-16(10-15)2-1-7-28-22)12-21(27)19(20)14-30-13-17-4-6-23-29-8-9-31(23)24(17)25(30)32/h1-12H,13-14H2 LRGNDOXRGWGFNG-UHFFFAOYSA-N 361634 US10221175, Compound 39 Muscarinic acetylcholine receptor M1 Human 857 US Patent 10.7270/Q27W6FGP aid1797849 US10221175 Conn, PJ; Lindsley, CW; Emmitte, KA; Han, C; Engers, JL; Bender, AM 3/5/2019 10/27/2019 Vanderbilt University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361634 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10062&target=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361634&enzyme=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search 122648620 386401014 1 MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC Muscarinic acetylcholine receptor M1 ACM1_HUMAN P11229 Q96RH1 714995 Fc1cc(ccc1CN1Cc2ccc3nccn3c2C1=O)-n1cccn1 InChI=1S/C19H14FN5O/c20-16-10-15(25-8-1-6-22-25)4-2-13(16)11-23-12-14-3-5-17-21-7-9-24(17)18(14)19(23)26/h1-10H,11-12H2 OFAXHJIBFODXEQ-UHFFFAOYSA-N 361635 US10221175, Compound 40 Muscarinic acetylcholine receptor M1 Human 10000 US Patent 10.7270/Q27W6FGP aid1797849 US10221175 Conn, PJ; Lindsley, CW; Emmitte, KA; Han, C; Engers, JL; Bender, AM 3/5/2019 10/27/2019 Vanderbilt University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361635 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10062&target=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361635&enzyme=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search 122648607 386401015 1 MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC Muscarinic acetylcholine receptor M1 ACM1_HUMAN P11229 Q96RH1 714996 CNC(=O)c1ccc(CN2Cc3ccc4nccn4c3C2=O)cc1 InChI=1S/C18H16N4O2/c1-19-17(23)13-4-2-12(3-5-13)10-21-11-14-6-7-15-20-8-9-22(15)16(14)18(21)24/h2-9H,10-11H2,1H3,(H,19,23) KVZJZNYOXKRWHY-UHFFFAOYSA-N 361636 US10221175, Compound 41 Muscarinic acetylcholine receptor M1 Human 10000 US Patent 10.7270/Q27W6FGP aid1797849 US10221175 Conn, PJ; Lindsley, CW; Emmitte, KA; Han, C; Engers, JL; Bender, AM 3/5/2019 10/27/2019 Vanderbilt University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361636 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10062&target=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361636&enzyme=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search 122648621 386401016 1 MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC Muscarinic acetylcholine receptor M1 ACM1_HUMAN P11229 Q96RH1 714997 O=C1N(Cc2ccc(cc2)-n2nccn2)Cc2ccc3nccn3c12 InChI=1S/C18H14N6O/c25-18-17-14(3-6-16-19-9-10-23(16)17)12-22(18)11-13-1-4-15(5-2-13)24-20-7-8-21-24/h1-10H,11-12H2 MELXKGMMJUKJAR-UHFFFAOYSA-N 361637 US10221175, Compound 42 Muscarinic acetylcholine receptor M1 Human 10000 US Patent 10.7270/Q27W6FGP aid1797849 US10221175 Conn, PJ; Lindsley, CW; Emmitte, KA; Han, C; Engers, JL; Bender, AM 3/5/2019 10/27/2019 Vanderbilt University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=361637 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10062&target=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=361637&enzyme=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search 122648612 386401017 1 MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC Muscarinic acetylcholine receptor M1 ACM1_HUMAN P11229 Q96RH1