BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Date of publication Date in BindingDB Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID PubChem SID ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence 1 PDB ID(s) of Target Chain 1 UniProt (SwissProt) Recommended Name of Target Chain 1 UniProt (SwissProt) Entry Name of Target Chain 1 UniProt (SwissProt) Primary ID of Target Chain 1 UniProt (SwissProt) Secondary ID(s) of Target Chain 1 UniProt (SwissProt) Alternative ID(s) of Target Chain 1 UniProt (TrEMBL) Submitted Name of Target Chain 1 UniProt (TrEMBL) Entry Name of Target Chain 1 UniProt (TrEMBL) Primary ID of Target Chain 1 UniProt (TrEMBL) Secondary ID(s) of Target Chain 1 UniProt (TrEMBL) Alternative ID(s) of Target Chain 1 BindingDB Target Chain Sequence 2 PDB ID(s) of Target Chain 2 UniProt (SwissProt) Recommended Name of Target Chain 2 UniProt (SwissProt) Entry Name of Target Chain 2 UniProt (SwissProt) Primary ID of Target Chain 2 UniProt (SwissProt) Secondary ID(s) of Target Chain 2 UniProt (SwissProt) Alternative ID(s) of Target Chain 2 UniProt (TrEMBL) Submitted Name of Target Chain 2 UniProt (TrEMBL) Entry Name of Target Chain 2 UniProt (TrEMBL) Primary ID of Target Chain 2 UniProt (TrEMBL) Secondary ID(s) of Target Chain 2 UniProt (TrEMBL) Alternative ID(s) of Target Chain 2 BindingDB Target Chain Sequence 3 PDB ID(s) of Target Chain 3 UniProt (SwissProt) Recommended Name of Target Chain 3 UniProt (SwissProt) Entry Name of Target Chain 3 UniProt (SwissProt) Primary ID of Target Chain 3 UniProt (SwissProt) Secondary ID(s) of Target Chain 3 UniProt (SwissProt) Alternative ID(s) of Target Chain 3 UniProt (TrEMBL) Submitted Name of Target Chain 3 UniProt (TrEMBL) Entry Name of Target Chain 3 UniProt (TrEMBL) Primary ID of Target Chain 3 UniProt (TrEMBL) Secondary ID(s) of Target Chain 3 UniProt (TrEMBL) Alternative ID(s) of Target Chain 3 BindingDB Target Chain Sequence 4 PDB ID(s) of Target Chain 4 UniProt (SwissProt) Recommended Name of Target Chain 4 UniProt (SwissProt) Entry Name of Target Chain 4 UniProt (SwissProt) Primary ID of Target Chain 4 UniProt (SwissProt) Secondary ID(s) of Target Chain 4 UniProt (SwissProt) Alternative ID(s) of Target Chain 4 UniProt (TrEMBL) Submitted Name of Target Chain 4 UniProt (TrEMBL) Entry Name of Target Chain 4 UniProt (TrEMBL) Primary ID of Target Chain 4 UniProt (TrEMBL) Secondary ID(s) of Target Chain 4 UniProt (TrEMBL) Alternative ID(s) of Target Chain 4 BindingDB Target Chain Sequence 5 PDB ID(s) of Target Chain 5 UniProt (SwissProt) Recommended Name of Target Chain 5 UniProt (SwissProt) Entry Name of Target Chain 5 UniProt (SwissProt) Primary ID of Target Chain 5 UniProt (SwissProt) Secondary ID(s) of Target Chain 5 UniProt (SwissProt) Alternative ID(s) of Target Chain 5 UniProt (TrEMBL) Submitted Name of Target Chain 5 UniProt (TrEMBL) Entry Name of Target Chain 5 UniProt (TrEMBL) Primary ID of Target Chain 5 UniProt (TrEMBL) Secondary ID(s) of Target Chain 5 UniProt (TrEMBL) Alternative ID(s) of Target Chain 5 BindingDB Target Chain Sequence 6 PDB ID(s) of Target Chain 6 UniProt (SwissProt) Recommended Name of Target Chain 6 UniProt (SwissProt) Entry Name of Target Chain 6 UniProt (SwissProt) Primary ID of Target Chain 6 UniProt (SwissProt) Secondary ID(s) of Target Chain 6 UniProt (SwissProt) Alternative ID(s) of Target Chain 6 UniProt (TrEMBL) Submitted Name of Target Chain 6 UniProt (TrEMBL) Entry Name of Target Chain 6 UniProt (TrEMBL) Primary ID of Target Chain 6 UniProt (TrEMBL) Secondary ID(s) of Target Chain 6 UniProt (TrEMBL) Alternative ID(s) of Target Chain 6 BindingDB Target Chain Sequence 7 PDB ID(s) of Target Chain 7 UniProt (SwissProt) Recommended Name of Target Chain 7 UniProt (SwissProt) Entry Name of Target Chain 7 UniProt (SwissProt) Primary ID of Target Chain 7 UniProt (SwissProt) Secondary ID(s) of Target Chain 7 UniProt (SwissProt) Alternative ID(s) of Target Chain 7 UniProt (TrEMBL) Submitted Name of Target Chain 7 UniProt (TrEMBL) Entry Name of Target Chain 7 UniProt (TrEMBL) Primary ID of Target Chain 7 UniProt (TrEMBL) Secondary ID(s) of Target Chain 7 UniProt (TrEMBL) Alternative ID(s) of Target Chain 7 BindingDB Target Chain Sequence 8 PDB ID(s) of Target Chain 8 UniProt (SwissProt) Recommended Name of Target Chain 8 UniProt (SwissProt) Entry Name of Target Chain 8 UniProt (SwissProt) Primary ID of Target Chain 8 UniProt (SwissProt) Secondary ID(s) of Target Chain 8 UniProt (SwissProt) Alternative ID(s) of Target Chain 8 UniProt (TrEMBL) Submitted Name of Target Chain 8 UniProt (TrEMBL) Entry Name of Target Chain 8 UniProt (TrEMBL) Primary ID of Target Chain 8 UniProt (TrEMBL) Secondary ID(s) of Target Chain 8 UniProt (TrEMBL) Alternative ID(s) of Target Chain 8 BindingDB Target Chain Sequence 9 PDB ID(s) of Target Chain 9 UniProt (SwissProt) Recommended Name of Target Chain 9 UniProt (SwissProt) Entry Name of Target Chain 9 UniProt (SwissProt) Primary ID of Target Chain 9 UniProt (SwissProt) Secondary ID(s) of Target Chain 9 UniProt (SwissProt) Alternative ID(s) of Target Chain 9 UniProt (TrEMBL) Submitted Name of Target Chain 9 UniProt (TrEMBL) Entry Name of Target Chain 9 UniProt (TrEMBL) Primary ID of Target Chain 9 UniProt (TrEMBL) Secondary ID(s) of Target Chain 9 UniProt (TrEMBL) Alternative ID(s) of Target Chain 9 BindingDB Target Chain Sequence 10 PDB ID(s) of Target Chain 10 UniProt (SwissProt) Recommended Name of Target Chain 10 UniProt (SwissProt) Entry Name of Target Chain 10 UniProt (SwissProt) Primary ID of Target Chain 10 UniProt (SwissProt) Secondary ID(s) of Target Chain 10 UniProt (SwissProt) Alternative ID(s) of Target Chain 10 UniProt (TrEMBL) Submitted Name of Target Chain 10 UniProt (TrEMBL) Entry Name of Target Chain 10 UniProt (TrEMBL) Primary ID of Target Chain 10 UniProt (TrEMBL) Secondary ID(s) of Target Chain 10 UniProt (TrEMBL) Alternative ID(s) of Target Chain 10 BindingDB Target Chain Sequence 11 PDB ID(s) of Target Chain 11 UniProt (SwissProt) Recommended Name of Target Chain 11 UniProt (SwissProt) Entry Name of Target Chain 11 UniProt (SwissProt) Primary ID of Target Chain 11 UniProt (SwissProt) Secondary ID(s) of Target Chain 11 UniProt (SwissProt) Alternative ID(s) of Target Chain 11 UniProt (TrEMBL) Submitted Name of Target Chain 11 UniProt (TrEMBL) Entry Name of Target Chain 11 UniProt (TrEMBL) Primary ID of Target Chain 11 UniProt (TrEMBL) Secondary ID(s) of Target Chain 11 UniProt (TrEMBL) Alternative ID(s) of Target Chain 11 BindingDB Target Chain Sequence 12 PDB ID(s) of Target Chain 12 UniProt (SwissProt) Recommended Name of Target Chain 12 UniProt (SwissProt) Entry Name of Target Chain 12 UniProt (SwissProt) Primary ID of Target Chain 12 UniProt (SwissProt) Secondary ID(s) of Target Chain 12 UniProt (SwissProt) Alternative ID(s) of Target Chain 12 UniProt (TrEMBL) Submitted Name of Target Chain 12 UniProt (TrEMBL) Entry Name of Target Chain 12 UniProt (TrEMBL) Primary ID of Target Chain 12 UniProt (TrEMBL) Secondary ID(s) of Target Chain 12 UniProt (TrEMBL) Alternative ID(s) of Target Chain 12 BindingDB Target Chain Sequence 13 PDB ID(s) of Target Chain 13 UniProt (SwissProt) Recommended Name of Target Chain 13 UniProt (SwissProt) Entry Name of Target Chain 13 UniProt (SwissProt) Primary ID of Target Chain 13 UniProt (SwissProt) Secondary ID(s) of Target Chain 13 UniProt (SwissProt) Alternative ID(s) of Target Chain 13 UniProt (TrEMBL) Submitted Name of Target Chain 13 UniProt (TrEMBL) Entry Name of Target Chain 13 UniProt (TrEMBL) Primary ID of Target Chain 13 UniProt (TrEMBL) Secondary ID(s) of Target Chain 13 UniProt (TrEMBL) Alternative ID(s) of Target Chain 13 BindingDB Target Chain Sequence 14 PDB ID(s) of Target Chain 14 UniProt (SwissProt) Recommended Name of Target Chain 14 UniProt (SwissProt) Entry Name of Target Chain 14 UniProt (SwissProt) Primary ID of Target Chain 14 UniProt (SwissProt) Secondary ID(s) of Target Chain 14 UniProt (SwissProt) Alternative ID(s) of Target Chain 14 UniProt (TrEMBL) Submitted Name of Target Chain 14 UniProt (TrEMBL) Entry Name of Target Chain 14 UniProt (TrEMBL) Primary ID of Target Chain 14 UniProt (TrEMBL) Secondary ID(s) of Target Chain 14 UniProt (TrEMBL) Alternative ID(s) of Target Chain 14 BindingDB Target Chain Sequence 15 PDB ID(s) of Target Chain 15 UniProt (SwissProt) Recommended Name of Target Chain 15 UniProt (SwissProt) Entry Name of Target Chain 15 UniProt (SwissProt) Primary ID of Target Chain 15 UniProt (SwissProt) Secondary ID(s) of Target Chain 15 UniProt (SwissProt) Alternative ID(s) of Target Chain 15 UniProt (TrEMBL) Submitted Name of Target Chain 15 UniProt (TrEMBL) Entry Name of Target Chain 15 UniProt (TrEMBL) Primary ID of Target Chain 15 UniProt (TrEMBL) Secondary ID(s) of Target Chain 15 UniProt (TrEMBL) Alternative ID(s) of Target Chain 15 BindingDB Target Chain Sequence 16 PDB ID(s) of Target Chain 16 UniProt (SwissProt) Recommended Name of Target Chain 16 UniProt (SwissProt) Entry Name of Target Chain 16 UniProt (SwissProt) Primary ID of Target Chain 16 UniProt (SwissProt) Secondary ID(s) of Target Chain 16 UniProt (SwissProt) Alternative ID(s) of Target Chain 16 UniProt (TrEMBL) Submitted Name of Target Chain 16 UniProt (TrEMBL) Entry Name of Target Chain 16 UniProt (TrEMBL) Primary ID of Target Chain 16 UniProt (TrEMBL) Secondary ID(s) of Target Chain 16 UniProt (TrEMBL) Alternative ID(s) of Target Chain 16 BindingDB Target Chain Sequence 17 PDB ID(s) of Target Chain 17 UniProt (SwissProt) Recommended Name of Target Chain 17 UniProt (SwissProt) Entry Name of Target Chain 17 UniProt (SwissProt) Primary ID of Target Chain 17 UniProt (SwissProt) Secondary ID(s) of Target Chain 17 UniProt (SwissProt) Alternative ID(s) of Target Chain 17 UniProt (TrEMBL) Submitted Name of Target Chain 17 UniProt (TrEMBL) Entry Name of Target Chain 17 UniProt (TrEMBL) Primary ID of Target Chain 17 UniProt (TrEMBL) Secondary ID(s) of Target Chain 17 UniProt (TrEMBL) Alternative ID(s) of Target Chain 17 BindingDB Target Chain Sequence 18 PDB ID(s) of Target Chain 18 UniProt (SwissProt) Recommended Name of Target Chain 18 UniProt (SwissProt) Entry Name of Target Chain 18 UniProt (SwissProt) Primary ID of Target Chain 18 UniProt (SwissProt) Secondary ID(s) of Target Chain 18 UniProt (SwissProt) Alternative ID(s) of Target Chain 18 UniProt (TrEMBL) Submitted Name of Target Chain 18 UniProt (TrEMBL) Entry Name of Target Chain 18 UniProt (TrEMBL) Primary ID of Target Chain 18 UniProt (TrEMBL) Secondary ID(s) of Target Chain 18 UniProt (TrEMBL) Alternative ID(s) of Target Chain 18 BindingDB Target Chain Sequence 19 PDB ID(s) of Target Chain 19 UniProt (SwissProt) Recommended Name of Target Chain 19 UniProt (SwissProt) Entry Name of Target Chain 19 UniProt (SwissProt) Primary ID of Target Chain 19 UniProt (SwissProt) Secondary ID(s) of Target Chain 19 UniProt (SwissProt) Alternative ID(s) of Target Chain 19 UniProt (TrEMBL) Submitted Name of Target Chain 19 UniProt (TrEMBL) Entry Name of Target Chain 19 UniProt (TrEMBL) Primary ID of Target Chain 19 UniProt (TrEMBL) Secondary ID(s) of Target Chain 19 UniProt (TrEMBL) Alternative ID(s) of Target Chain 19 BindingDB Target Chain Sequence 20 PDB ID(s) of Target Chain 20 UniProt (SwissProt) Recommended Name of Target Chain 20 UniProt (SwissProt) Entry Name of Target Chain 20 UniProt (SwissProt) Primary ID of Target Chain 20 UniProt (SwissProt) Secondary ID(s) of Target Chain 20 UniProt (SwissProt) Alternative ID(s) of Target Chain 20 UniProt (TrEMBL) Submitted Name of Target Chain 20 UniProt (TrEMBL) Entry Name of Target Chain 20 UniProt (TrEMBL) Primary ID of Target Chain 20 UniProt (TrEMBL) Secondary ID(s) of Target Chain 20 UniProt (TrEMBL) Alternative ID(s) of Target Chain 20 BindingDB Target Chain Sequence 21 PDB ID(s) of Target Chain 21 UniProt (SwissProt) Recommended Name of Target Chain 21 UniProt (SwissProt) Entry Name of Target Chain 21 UniProt (SwissProt) Primary ID of Target Chain 21 UniProt (SwissProt) Secondary ID(s) of Target Chain 21 UniProt (SwissProt) Alternative ID(s) of Target Chain 21 UniProt (TrEMBL) Submitted Name of Target Chain 21 UniProt (TrEMBL) Entry Name of Target Chain 21 UniProt (TrEMBL) Primary ID of Target Chain 21 UniProt (TrEMBL) Secondary ID(s) of Target Chain 21 UniProt (TrEMBL) Alternative ID(s) of Target Chain 21 BindingDB Target Chain Sequence 22 PDB ID(s) of Target Chain 22 UniProt (SwissProt) Recommended Name of Target Chain 22 UniProt (SwissProt) Entry Name of Target Chain 22 UniProt (SwissProt) Primary ID of Target Chain 22 UniProt (SwissProt) Secondary ID(s) of Target Chain 22 UniProt (SwissProt) Alternative ID(s) of Target Chain 22 UniProt (TrEMBL) Submitted Name of Target Chain 22 UniProt (TrEMBL) Entry Name of Target Chain 22 UniProt (TrEMBL) Primary ID of Target Chain 22 UniProt (TrEMBL) Secondary ID(s) of Target Chain 22 UniProt (TrEMBL) Alternative ID(s) of Target Chain 22 BindingDB Target Chain Sequence 23 PDB ID(s) of Target Chain 23 UniProt (SwissProt) Recommended Name of Target Chain 23 UniProt (SwissProt) Entry Name of Target Chain 23 UniProt (SwissProt) Primary ID of Target Chain 23 UniProt (SwissProt) Secondary ID(s) of Target Chain 23 UniProt (SwissProt) Alternative ID(s) of Target Chain 23 UniProt (TrEMBL) Submitted Name of Target Chain 23 UniProt (TrEMBL) Entry Name of Target Chain 23 UniProt (TrEMBL) Primary ID of Target Chain 23 UniProt (TrEMBL) Secondary ID(s) of Target Chain 23 UniProt (TrEMBL) Alternative ID(s) of Target Chain 23 BindingDB Target Chain Sequence 24 PDB ID(s) of Target Chain 24 UniProt (SwissProt) Recommended Name of Target Chain 24 UniProt (SwissProt) Entry Name of Target Chain 24 UniProt (SwissProt) Primary ID of Target Chain 24 UniProt (SwissProt) Secondary ID(s) of Target Chain 24 UniProt (SwissProt) Alternative ID(s) of Target Chain 24 UniProt (TrEMBL) Submitted Name of Target Chain 24 UniProt (TrEMBL) Entry Name of Target Chain 24 UniProt (TrEMBL) Primary ID of Target Chain 24 UniProt (TrEMBL) Secondary ID(s) of Target Chain 24 UniProt (TrEMBL) Alternative ID(s) of Target Chain 24 BindingDB Target Chain Sequence 25 PDB ID(s) of Target Chain 25 UniProt (SwissProt) Recommended Name of Target Chain 25 UniProt (SwissProt) Entry Name of Target Chain 25 UniProt (SwissProt) Primary ID of Target Chain 25 UniProt (SwissProt) Secondary ID(s) of Target Chain 25 UniProt (SwissProt) Alternative ID(s) of Target Chain 25 UniProt (TrEMBL) Submitted Name of Target Chain 25 UniProt (TrEMBL) Entry Name of Target Chain 25 UniProt (TrEMBL) Primary ID of Target Chain 25 UniProt (TrEMBL) Secondary ID(s) of Target Chain 25 UniProt (TrEMBL) Alternative ID(s) of Target Chain 25 BindingDB Target Chain Sequence 26 PDB ID(s) of Target Chain 26 UniProt (SwissProt) Recommended Name of Target Chain 26 UniProt (SwissProt) Entry Name of Target Chain 26 UniProt (SwissProt) Primary ID of Target Chain 26 UniProt (SwissProt) Secondary ID(s) of Target Chain 26 UniProt (SwissProt) Alternative ID(s) of Target Chain 26 UniProt (TrEMBL) Submitted Name of Target Chain 26 UniProt (TrEMBL) Entry Name of Target Chain 26 UniProt (TrEMBL) Primary ID of Target Chain 26 UniProt (TrEMBL) Secondary ID(s) of Target Chain 26 UniProt (TrEMBL) Alternative ID(s) of Target Chain 26 BindingDB Target Chain Sequence 27 PDB ID(s) of Target Chain 27 UniProt (SwissProt) Recommended Name of Target Chain 27 UniProt (SwissProt) Entry Name of Target Chain 27 UniProt (SwissProt) Primary ID of Target Chain 27 UniProt (SwissProt) Secondary ID(s) of Target Chain 27 UniProt (SwissProt) Alternative ID(s) of Target Chain 27 UniProt (TrEMBL) Submitted Name of Target Chain 27 UniProt (TrEMBL) Entry Name of Target Chain 27 UniProt (TrEMBL) Primary ID of Target Chain 27 UniProt (TrEMBL) Secondary ID(s) of Target Chain 27 UniProt (TrEMBL) Alternative ID(s) of Target Chain 27 BindingDB Target Chain Sequence 28 PDB ID(s) of Target Chain 28 UniProt (SwissProt) Recommended Name of Target Chain 28 UniProt (SwissProt) Entry Name of Target Chain 28 UniProt (SwissProt) Primary ID of Target Chain 28 UniProt (SwissProt) Secondary ID(s) of Target Chain 28 UniProt (SwissProt) Alternative ID(s) of Target Chain 28 UniProt (TrEMBL) Submitted Name of Target Chain 28 UniProt (TrEMBL) Entry Name of Target Chain 28 UniProt (TrEMBL) Primary ID of Target Chain 28 UniProt (TrEMBL) Secondary ID(s) of Target Chain 28 UniProt (TrEMBL) Alternative ID(s) of Target Chain 28 BindingDB Target Chain Sequence 29 PDB ID(s) of Target Chain 29 UniProt (SwissProt) Recommended Name of Target Chain 29 UniProt (SwissProt) Entry Name of Target Chain 29 UniProt (SwissProt) Primary ID of Target Chain 29 UniProt (SwissProt) Secondary ID(s) of Target Chain 29 UniProt (SwissProt) Alternative ID(s) of Target Chain 29 UniProt (TrEMBL) Submitted Name of Target Chain 29 UniProt (TrEMBL) Entry Name of Target Chain 29 UniProt (TrEMBL) Primary ID of Target Chain 29 UniProt (TrEMBL) Secondary ID(s) of Target Chain 29 UniProt (TrEMBL) Alternative ID(s) of Target Chain 29 BindingDB Target Chain Sequence 30 PDB ID(s) of Target Chain 30 UniProt (SwissProt) Recommended Name of Target Chain 30 UniProt (SwissProt) Entry Name of Target Chain 30 UniProt (SwissProt) Primary ID of Target Chain 30 UniProt (SwissProt) Secondary ID(s) of Target Chain 30 UniProt (SwissProt) Alternative ID(s) of Target Chain 30 UniProt (TrEMBL) Submitted Name of Target Chain 30 UniProt (TrEMBL) Entry Name of Target Chain 30 UniProt (TrEMBL) Primary ID of Target Chain 30 UniProt (TrEMBL) Secondary ID(s) of Target Chain 30 UniProt (TrEMBL) Alternative ID(s) of Target Chain 30 BindingDB Target Chain Sequence 31 PDB ID(s) of Target Chain 31 UniProt (SwissProt) Recommended Name of Target Chain 31 UniProt (SwissProt) Entry Name of Target Chain 31 UniProt (SwissProt) Primary ID of Target Chain 31 UniProt (SwissProt) Secondary ID(s) of Target Chain 31 UniProt (SwissProt) Alternative ID(s) of Target Chain 31 UniProt (TrEMBL) Submitted Name of Target Chain 31 UniProt (TrEMBL) Entry Name of Target Chain 31 UniProt (TrEMBL) Primary ID of Target Chain 31 UniProt (TrEMBL) Secondary ID(s) of Target Chain 31 UniProt (TrEMBL) Alternative ID(s) of Target Chain 31 BindingDB Target Chain Sequence 32 PDB ID(s) of Target Chain 32 UniProt (SwissProt) Recommended Name of Target Chain 32 UniProt (SwissProt) Entry Name of Target Chain 32 UniProt (SwissProt) Primary ID of Target Chain 32 UniProt (SwissProt) Secondary ID(s) of Target Chain 32 UniProt (SwissProt) Alternative ID(s) of Target Chain 32 UniProt (TrEMBL) Submitted Name of Target Chain 32 UniProt (TrEMBL) Entry Name of Target Chain 32 UniProt (TrEMBL) Primary ID of Target Chain 32 UniProt (TrEMBL) Secondary ID(s) of Target Chain 32 UniProt (TrEMBL) Alternative ID(s) of Target Chain 32 BindingDB Target Chain Sequence 33 PDB ID(s) of Target Chain 33 UniProt (SwissProt) Recommended Name of Target Chain 33 UniProt (SwissProt) Entry Name of Target Chain 33 UniProt (SwissProt) Primary ID of Target Chain 33 UniProt (SwissProt) Secondary ID(s) of Target Chain 33 UniProt (SwissProt) Alternative ID(s) of Target Chain 33 UniProt (TrEMBL) Submitted Name of Target Chain 33 UniProt (TrEMBL) Entry Name of Target Chain 33 UniProt (TrEMBL) Primary ID of Target Chain 33 UniProt (TrEMBL) Secondary ID(s) of Target Chain 33 UniProt (TrEMBL) Alternative ID(s) of Target Chain 33 BindingDB Target Chain Sequence 34 PDB ID(s) of Target Chain 34 UniProt (SwissProt) Recommended Name of Target Chain 34 UniProt (SwissProt) Entry Name of Target Chain 34 UniProt (SwissProt) Primary ID of Target Chain 34 UniProt (SwissProt) Secondary ID(s) of Target Chain 34 UniProt (SwissProt) Alternative ID(s) of Target Chain 34 UniProt (TrEMBL) Submitted Name of Target Chain 34 UniProt (TrEMBL) Entry Name of Target Chain 34 UniProt (TrEMBL) Primary ID of Target Chain 34 UniProt (TrEMBL) Secondary ID(s) of Target Chain 34 UniProt (TrEMBL) Alternative ID(s) of Target Chain 34 BindingDB Target Chain Sequence 35 PDB ID(s) of Target Chain 35 UniProt (SwissProt) Recommended Name of Target Chain 35 UniProt (SwissProt) Entry Name of Target Chain 35 UniProt (SwissProt) Primary ID of Target Chain 35 UniProt (SwissProt) Secondary ID(s) of Target Chain 35 UniProt (SwissProt) Alternative ID(s) of Target Chain 35 UniProt (TrEMBL) Submitted Name of Target Chain 35 UniProt (TrEMBL) Entry Name of Target Chain 35 UniProt (TrEMBL) Primary ID of Target Chain 35 UniProt (TrEMBL) Secondary ID(s) of Target Chain 35 UniProt (TrEMBL) Alternative ID(s) of Target Chain 35 BindingDB Target Chain Sequence 36 PDB ID(s) of Target Chain 36 UniProt (SwissProt) Recommended Name of Target Chain 36 UniProt (SwissProt) Entry Name of Target Chain 36 UniProt (SwissProt) Primary ID of Target Chain 36 UniProt (SwissProt) Secondary ID(s) of Target Chain 36 UniProt (SwissProt) Alternative ID(s) of Target Chain 36 UniProt (TrEMBL) Submitted Name of Target Chain 36 UniProt (TrEMBL) Entry Name of Target Chain 36 UniProt (TrEMBL) Primary ID of Target Chain 36 UniProt (TrEMBL) Secondary ID(s) of Target Chain 36 UniProt (TrEMBL) Alternative ID(s) of Target Chain 36 BindingDB Target Chain Sequence 37 PDB ID(s) of Target Chain 37 UniProt (SwissProt) Recommended Name of Target Chain 37 UniProt (SwissProt) Entry Name of Target Chain 37 UniProt (SwissProt) Primary ID of Target Chain 37 UniProt (SwissProt) Secondary ID(s) of Target Chain 37 UniProt (SwissProt) Alternative ID(s) of Target Chain 37 UniProt (TrEMBL) Submitted Name of Target Chain 37 UniProt (TrEMBL) Entry Name of Target Chain 37 UniProt (TrEMBL) Primary ID of Target Chain 37 UniProt (TrEMBL) Secondary ID(s) of Target Chain 37 UniProt (TrEMBL) Alternative ID(s) of Target Chain 37 BindingDB Target Chain Sequence 38 PDB ID(s) of Target Chain 38 UniProt (SwissProt) Recommended Name of Target Chain 38 UniProt (SwissProt) Entry Name of Target Chain 38 UniProt (SwissProt) Primary ID of Target Chain 38 UniProt (SwissProt) Secondary ID(s) of Target Chain 38 UniProt (SwissProt) Alternative ID(s) of Target Chain 38 UniProt (TrEMBL) Submitted Name of Target Chain 38 UniProt (TrEMBL) Entry Name of Target Chain 38 UniProt (TrEMBL) Primary ID of Target Chain 38 UniProt (TrEMBL) Secondary ID(s) of Target Chain 38 UniProt (TrEMBL) Alternative ID(s) of Target Chain 38 BindingDB Target Chain Sequence 39 PDB ID(s) of Target Chain 39 UniProt (SwissProt) Recommended Name of Target Chain 39 UniProt (SwissProt) Entry Name of Target Chain 39 UniProt (SwissProt) Primary ID of Target Chain 39 UniProt (SwissProt) Secondary ID(s) of Target Chain 39 UniProt (SwissProt) Alternative ID(s) of Target Chain 39 UniProt (TrEMBL) Submitted Name of Target Chain 39 UniProt (TrEMBL) Entry Name of Target Chain 39 UniProt (TrEMBL) Primary ID of Target Chain 39 UniProt (TrEMBL) Secondary ID(s) of Target Chain 39 UniProt (TrEMBL) Alternative ID(s) of Target Chain 39 BindingDB Target Chain Sequence 40 PDB ID(s) of Target Chain 40 UniProt (SwissProt) Recommended Name of Target Chain 40 UniProt (SwissProt) Entry Name of Target Chain 40 UniProt (SwissProt) Primary ID of Target Chain 40 UniProt (SwissProt) Secondary ID(s) of Target Chain 40 UniProt (SwissProt) Alternative ID(s) of Target Chain 40 UniProt (TrEMBL) Submitted Name of Target Chain 40 UniProt (TrEMBL) Entry Name of Target Chain 40 UniProt (TrEMBL) Primary ID of Target Chain 40 UniProt (TrEMBL) Secondary ID(s) of Target Chain 40 UniProt (TrEMBL) Alternative ID(s) of Target Chain 40 BindingDB Target Chain Sequence 41 PDB ID(s) of Target Chain 41 UniProt (SwissProt) Recommended Name of Target Chain 41 UniProt (SwissProt) Entry Name of Target Chain 41 UniProt (SwissProt) Primary ID of Target Chain 41 UniProt (SwissProt) Secondary ID(s) of Target Chain 41 UniProt (SwissProt) Alternative ID(s) of Target Chain 41 UniProt (TrEMBL) Submitted Name of Target Chain 41 UniProt (TrEMBL) Entry Name of Target Chain 41 UniProt (TrEMBL) Primary ID of Target Chain 41 UniProt (TrEMBL) Secondary ID(s) of Target Chain 41 UniProt (TrEMBL) Alternative ID(s) of Target Chain 41 BindingDB Target Chain Sequence 42 PDB ID(s) of Target Chain 42 UniProt (SwissProt) Recommended Name of Target Chain 42 UniProt (SwissProt) Entry Name of Target Chain 42 UniProt (SwissProt) Primary ID of Target Chain 42 UniProt (SwissProt) Secondary ID(s) of Target Chain 42 UniProt (SwissProt) Alternative ID(s) of Target Chain 42 UniProt (TrEMBL) Submitted Name of Target Chain 42 UniProt (TrEMBL) Entry Name of Target Chain 42 UniProt (TrEMBL) Primary ID of Target Chain 42 UniProt (TrEMBL) Secondary ID(s) of Target Chain 42 UniProt (TrEMBL) Alternative ID(s) of Target Chain 42 BindingDB Target Chain Sequence 43 PDB ID(s) of Target Chain 43 UniProt (SwissProt) Recommended Name of Target Chain 43 UniProt (SwissProt) Entry Name of Target Chain 43 UniProt (SwissProt) Primary ID of Target Chain 43 UniProt (SwissProt) Secondary ID(s) of Target Chain 43 UniProt (SwissProt) Alternative ID(s) of Target Chain 43 UniProt (TrEMBL) Submitted Name of Target Chain 43 UniProt (TrEMBL) Entry Name of Target Chain 43 UniProt (TrEMBL) Primary ID of Target Chain 43 UniProt (TrEMBL) Secondary ID(s) of Target Chain 43 UniProt (TrEMBL) Alternative ID(s) of Target Chain 43 BindingDB Target Chain Sequence 44 PDB ID(s) of Target Chain 44 UniProt (SwissProt) Recommended Name of Target Chain 44 UniProt (SwissProt) Entry Name of Target Chain 44 UniProt (SwissProt) Primary ID of Target Chain 44 UniProt (SwissProt) Secondary ID(s) of Target Chain 44 UniProt (SwissProt) Alternative ID(s) of Target Chain 44 UniProt (TrEMBL) Submitted Name of Target Chain 44 UniProt (TrEMBL) Entry Name of Target Chain 44 UniProt (TrEMBL) Primary ID of Target Chain 44 UniProt (TrEMBL) Secondary ID(s) of Target Chain 44 UniProt (TrEMBL) Alternative ID(s) of Target Chain 44 BindingDB Target Chain Sequence 45 PDB ID(s) of Target Chain 45 UniProt (SwissProt) Recommended Name of Target Chain 45 UniProt (SwissProt) Entry Name of Target Chain 45 UniProt (SwissProt) Primary ID of Target Chain 45 UniProt (SwissProt) Secondary ID(s) of Target Chain 45 UniProt (SwissProt) Alternative ID(s) of Target Chain 45 UniProt (TrEMBL) Submitted Name of Target Chain 45 UniProt (TrEMBL) Entry Name of Target Chain 45 UniProt (TrEMBL) Primary ID of Target Chain 45 UniProt (TrEMBL) Secondary ID(s) of Target Chain 45 UniProt (TrEMBL) Alternative ID(s) of Target Chain 45 BindingDB Target Chain Sequence 46 PDB ID(s) of Target Chain 46 UniProt (SwissProt) Recommended Name of Target Chain 46 UniProt (SwissProt) Entry Name of Target Chain 46 UniProt (SwissProt) Primary ID of Target Chain 46 UniProt (SwissProt) Secondary ID(s) of Target Chain 46 UniProt (SwissProt) Alternative ID(s) of Target Chain 46 UniProt (TrEMBL) Submitted Name of Target Chain 46 UniProt (TrEMBL) Entry Name of Target Chain 46 UniProt (TrEMBL) Primary ID of Target Chain 46 UniProt (TrEMBL) Secondary ID(s) of Target Chain 46 UniProt (TrEMBL) Alternative ID(s) of Target Chain 46 BindingDB Target Chain Sequence 47 PDB ID(s) of Target Chain 47 UniProt (SwissProt) Recommended Name of Target Chain 47 UniProt (SwissProt) Entry Name of Target Chain 47 UniProt (SwissProt) Primary ID of Target Chain 47 UniProt (SwissProt) Secondary ID(s) of Target Chain 47 UniProt (SwissProt) Alternative ID(s) of Target Chain 47 UniProt (TrEMBL) Submitted Name of Target Chain 47 UniProt (TrEMBL) Entry Name of Target Chain 47 UniProt (TrEMBL) Primary ID of Target Chain 47 UniProt (TrEMBL) Secondary ID(s) of Target Chain 47 UniProt (TrEMBL) Alternative ID(s) of Target Chain 47 BindingDB Target Chain Sequence 48 PDB ID(s) of Target Chain 48 UniProt (SwissProt) Recommended Name of Target Chain 48 UniProt (SwissProt) Entry Name of Target Chain 48 UniProt (SwissProt) Primary ID of Target Chain 48 UniProt (SwissProt) Secondary ID(s) of Target Chain 48 UniProt (SwissProt) Alternative ID(s) of Target Chain 48 UniProt (TrEMBL) Submitted Name of Target Chain 48 UniProt (TrEMBL) Entry Name of Target Chain 48 UniProt (TrEMBL) Primary ID of Target Chain 48 UniProt (TrEMBL) Secondary ID(s) of Target Chain 48 UniProt (TrEMBL) Alternative ID(s) of Target Chain 48 BindingDB Target Chain Sequence 49 PDB ID(s) of Target Chain 49 UniProt (SwissProt) Recommended Name of Target Chain 49 UniProt (SwissProt) Entry Name of Target Chain 49 UniProt (SwissProt) Primary ID of Target Chain 49 UniProt (SwissProt) Secondary ID(s) of Target Chain 49 UniProt (SwissProt) Alternative ID(s) of Target Chain 49 UniProt (TrEMBL) Submitted Name of Target Chain 49 UniProt (TrEMBL) Entry Name of Target Chain 49 UniProt (TrEMBL) Primary ID of Target Chain 49 UniProt (TrEMBL) Secondary ID(s) of Target Chain 49 UniProt (TrEMBL) Alternative ID(s) of Target Chain 49 BindingDB Target Chain Sequence 50 PDB ID(s) of Target Chain 50 UniProt (SwissProt) Recommended Name of Target Chain 50 UniProt (SwissProt) Entry Name of Target Chain 50 UniProt (SwissProt) Primary ID of Target Chain 50 UniProt (SwissProt) Secondary ID(s) of Target Chain 50 UniProt (SwissProt) Alternative ID(s) of Target Chain 50 UniProt (TrEMBL) Submitted Name of Target Chain 50 UniProt (TrEMBL) Entry Name of Target Chain 50 UniProt (TrEMBL) Primary ID of Target Chain 50 UniProt (TrEMBL) Secondary ID(s) of Target Chain 50 UniProt (TrEMBL) Alternative ID(s) of Target Chain 50 555222 CNC(=O)c1cccc(NC2C(NC(c3ccc(C)o3)C3(C)CCCO3)C(=O)C2=O)c1O InChI=1S/C23H27N3O6/c1-12-8-9-15(32-12)21(23(2)10-5-11-31-23)26-17-16(19(28)20(17)29)25-14-7-4-6-13(18(14)27)22(30)24-3/h4,6-9,16-17,21,25-27H,5,10-11H2,1-3H3,(H,24,30) AGJIIPQAPDGVQW-UHFFFAOYSA-N 291172 2-hydroxy-N,N-dimethyl-3-(2-{[(5-methylfuran-2-yl)-(2-methyltetrahydrofuran-2-yl)methyl]amino}-3,4-dioxocyclobut-1-enylamino)benzamide::US9580412, Example 1 C-X-C chemokine receptor type 1 Human 244 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291172 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7515&target=C-X-C+chemokine+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291172&enzyme=C-X-C+chemokine+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 126624206 381611478 1 MSNITDPQMWDFDDLNFTGMPPADEDYSPCMLETETLNKYVVIIAYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGCWGLSMNLSLPFFLFRQAYHPNNSSPVCYEVLGNDTAKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQESCERRNNIGRALDATEILGFLHSCLNPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHRVTSYTSSSVNVSSNL 8IC0,2LNL C-X-C chemokine receptor type 1 CXCR1_HUMAN P25024 B2R6Q3 Q2YEF8 Q2YEG4 Q2YEG5 Q2YEG7 Q2YEG8 Q53R18 Q6IN95 Q8N6T6 Q9P2T8 Q9P2T9 Q9P2U0 Q9P2U1 Q9P2U2 555223 CNC(=O)c1cccc(NC2C(NC(c3ccc(C)o3)C3(C)CCCO3)C(=O)C2=O)c1O InChI=1S/C23H27N3O6/c1-12-8-9-15(32-12)21(23(2)10-5-11-31-23)26-17-16(19(28)20(17)29)25-14-7-4-6-13(18(14)27)22(30)24-3/h4,6-9,16-17,21,25-27H,5,10-11H2,1-3H3,(H,24,30) AGJIIPQAPDGVQW-UHFFFAOYSA-N 291172 2-hydroxy-N,N-dimethyl-3-(2-{[(5-methylfuran-2-yl)-(2-methyltetrahydrofuran-2-yl)methyl]amino}-3,4-dioxocyclobut-1-enylamino)benzamide::US9580412, Example 1 C-X-C chemokine receptor type 2 Human 53.0 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291172 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5556&target=C-X-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291172&enzyme=C-X-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 126624206 381611478 1 MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL 6LFO,6LFM,8XXX,8XXR,8XXH,8XX7,8XX6,8XX3,8XWV,8XWS,8XWN,8XWM,8XWF,8XWA,8XVU C-X-C chemokine receptor type 2 CXCR2_HUMAN P25025 Q8IUZ1 Q9P2T6 Q9P2T7 555224 CNC(=O)c1cccc(NC2C(NC(c3ccc(C)o3)C3(C)CCCO3)C(=O)C2=O)c1O InChI=1S/C23H27N3O6/c1-12-8-9-15(32-12)21(23(2)10-5-11-31-23)26-17-16(19(28)20(17)29)25-14-7-4-6-13(18(14)27)22(30)24-3/h4,6-9,16-17,21,25-27H,5,10-11H2,1-3H3,(H,24,30) AGJIIPQAPDGVQW-UHFFFAOYSA-N 291172 2-hydroxy-N,N-dimethyl-3-(2-{[(5-methylfuran-2-yl)-(2-methyltetrahydrofuran-2-yl)methyl]amino}-3,4-dioxocyclobut-1-enylamino)benzamide::US9580412, Example 1 C-X-C chemokine receptor type 1 Human 9999 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291172 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7515&target=C-X-C+chemokine+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291172&enzyme=C-X-C+chemokine+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 126624206 381611478 1 MSNITDPQMWDFDDLNFTGMPPADEDYSPCMLETETLNKYVVIIAYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGCWGLSMNLSLPFFLFRQAYHPNNSSPVCYEVLGNDTAKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQESCERRNNIGRALDATEILGFLHSCLNPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHRVTSYTSSSVNVSSNL 8IC0,2LNL C-X-C chemokine receptor type 1 CXCR1_HUMAN P25024 B2R6Q3 Q2YEF8 Q2YEG4 Q2YEG5 Q2YEG7 Q2YEG8 Q53R18 Q6IN95 Q8N6T6 Q9P2T8 Q9P2T9 Q9P2U0 Q9P2U1 Q9P2U2 555225 CNC(=O)c1cccc(NC2C(NC(c3ccc(C)o3)C3(C)CCCO3)C(=O)C2=O)c1O InChI=1S/C23H27N3O6/c1-12-8-9-15(32-12)21(23(2)10-5-11-31-23)26-17-16(19(28)20(17)29)25-14-7-4-6-13(18(14)27)22(30)24-3/h4,6-9,16-17,21,25-27H,5,10-11H2,1-3H3,(H,24,30) AGJIIPQAPDGVQW-UHFFFAOYSA-N 291172 2-hydroxy-N,N-dimethyl-3-(2-{[(5-methylfuran-2-yl)-(2-methyltetrahydrofuran-2-yl)methyl]amino}-3,4-dioxocyclobut-1-enylamino)benzamide::US9580412, Example 1 C-X-C chemokine receptor type 2 Human 9999 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291172 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5556&target=C-X-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291172&enzyme=C-X-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 126624206 381611478 1 MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL 6LFO,6LFM,8XXX,8XXR,8XXH,8XX7,8XX6,8XX3,8XWV,8XWS,8XWN,8XWM,8XWF,8XWA,8XVU C-X-C chemokine receptor type 2 CXCR2_HUMAN P25025 Q8IUZ1 Q9P2T6 Q9P2T7 555226 CNC(=O)c1cccc(NC2C(NC(c3ccc(C)o3)C3(C)CCCO3)C(=O)C2=O)c1O InChI=1S/C23H27N3O6/c1-12-8-9-15(32-12)21(23(2)10-5-11-31-23)26-17-16(19(28)20(17)29)25-14-7-4-6-13(18(14)27)22(30)24-3/h4,6-9,16-17,21,25-27H,5,10-11H2,1-3H3,(H,24,30) AGJIIPQAPDGVQW-UHFFFAOYSA-N 291172 2-hydroxy-N,N-dimethyl-3-(2-{[(5-methylfuran-2-yl)-(2-methyltetrahydrofuran-2-yl)methyl]amino}-3,4-dioxocyclobut-1-enylamino)benzamide::US9580412, Example 1 C-X-C chemokine receptor type 1 Human 9999 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291172 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7515&target=C-X-C+chemokine+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291172&enzyme=C-X-C+chemokine+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 126624206 381611478 1 MSNITDPQMWDFDDLNFTGMPPADEDYSPCMLETETLNKYVVIIAYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGCWGLSMNLSLPFFLFRQAYHPNNSSPVCYEVLGNDTAKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQESCERRNNIGRALDATEILGFLHSCLNPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHRVTSYTSSSVNVSSNL 8IC0,2LNL C-X-C chemokine receptor type 1 CXCR1_HUMAN P25024 B2R6Q3 Q2YEF8 Q2YEG4 Q2YEG5 Q2YEG7 Q2YEG8 Q53R18 Q6IN95 Q8N6T6 Q9P2T8 Q9P2T9 Q9P2U0 Q9P2U1 Q9P2U2 555227 CNC(=O)c1cccc(NC2C(NC(c3ccc(C)o3)C3(C)CCCO3)C(=O)C2=O)c1O InChI=1S/C23H27N3O6/c1-12-8-9-15(32-12)21(23(2)10-5-11-31-23)26-17-16(19(28)20(17)29)25-14-7-4-6-13(18(14)27)22(30)24-3/h4,6-9,16-17,21,25-27H,5,10-11H2,1-3H3,(H,24,30) AGJIIPQAPDGVQW-UHFFFAOYSA-N 291172 2-hydroxy-N,N-dimethyl-3-(2-{[(5-methylfuran-2-yl)-(2-methyltetrahydrofuran-2-yl)methyl]amino}-3,4-dioxocyclobut-1-enylamino)benzamide::US9580412, Example 1 C-X-C chemokine receptor type 2 Human 9999 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291172 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5556&target=C-X-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291172&enzyme=C-X-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 126624206 381611478 1 MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL 6LFO,6LFM,8XXX,8XXR,8XXH,8XX7,8XX6,8XX3,8XWV,8XWS,8XWN,8XWM,8XWF,8XWA,8XVU C-X-C chemokine receptor type 2 CXCR2_HUMAN P25025 Q8IUZ1 Q9P2T6 Q9P2T7 555228 CNC(=O)c1cccc(NC2C(NC(c3ccc(C)o3)C3(C)CCCO3)C(=O)C2=O)c1O InChI=1S/C23H27N3O6/c1-12-8-9-15(32-12)21(23(2)10-5-11-31-23)26-17-16(19(28)20(17)29)25-14-7-4-6-13(18(14)27)22(30)24-3/h4,6-9,16-17,21,25-27H,5,10-11H2,1-3H3,(H,24,30) AGJIIPQAPDGVQW-UHFFFAOYSA-N 291172 2-hydroxy-N,N-dimethyl-3-(2-{[(5-methylfuran-2-yl)-(2-methyltetrahydrofuran-2-yl)methyl]amino}-3,4-dioxocyclobut-1-enylamino)benzamide::US9580412, Example 1 C-X-C chemokine receptor type 1 Human 9999 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291172 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7515&target=C-X-C+chemokine+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291172&enzyme=C-X-C+chemokine+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 126624206 381611478 1 MSNITDPQMWDFDDLNFTGMPPADEDYSPCMLETETLNKYVVIIAYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGCWGLSMNLSLPFFLFRQAYHPNNSSPVCYEVLGNDTAKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQESCERRNNIGRALDATEILGFLHSCLNPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHRVTSYTSSSVNVSSNL 8IC0,2LNL C-X-C chemokine receptor type 1 CXCR1_HUMAN P25024 B2R6Q3 Q2YEF8 Q2YEG4 Q2YEG5 Q2YEG7 Q2YEG8 Q53R18 Q6IN95 Q8N6T6 Q9P2T8 Q9P2T9 Q9P2U0 Q9P2U1 Q9P2U2 555229 CNC(=O)c1cccc(NC2C(NC(c3ccc(C)o3)C3(C)CCCO3)C(=O)C2=O)c1O InChI=1S/C23H27N3O6/c1-12-8-9-15(32-12)21(23(2)10-5-11-31-23)26-17-16(19(28)20(17)29)25-14-7-4-6-13(18(14)27)22(30)24-3/h4,6-9,16-17,21,25-27H,5,10-11H2,1-3H3,(H,24,30) AGJIIPQAPDGVQW-UHFFFAOYSA-N 291172 2-hydroxy-N,N-dimethyl-3-(2-{[(5-methylfuran-2-yl)-(2-methyltetrahydrofuran-2-yl)methyl]amino}-3,4-dioxocyclobut-1-enylamino)benzamide::US9580412, Example 1 C-X-C chemokine receptor type 2 Human 9999 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291172 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5556&target=C-X-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291172&enzyme=C-X-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 126624206 381611478 1 MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL 6LFO,6LFM,8XXX,8XXR,8XXH,8XX7,8XX6,8XX3,8XWV,8XWS,8XWN,8XWM,8XWF,8XWA,8XVU C-X-C chemokine receptor type 2 CXCR2_HUMAN P25025 Q8IUZ1 Q9P2T6 Q9P2T7 555230 CN(C)C(=O)c1cccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O InChI=1S/C23H25N3O5S/c1-12-9-10-15(31-12)17(16-8-5-11-32-16)25-19-18(21(28)22(19)29)24-14-7-4-6-13(20(14)27)23(30)26(2)3/h4,6-7,9-10,16-17,24-25,27H,5,8,11H2,1-3H3 KCVWGCOBGFLUEB-UHFFFAOYSA-N 236795 US9388149, 2 (Enantiomer 1 of diastereoisomer 2)::US9388149, 2 (Enantiomer 2 of diastereoisomer 2)::US9388149, 2 (Enantiomer 1 of diastereoisomer 1)::US9388149, 2 (Diastereoisomer 2)::US9388149, 2 (Diastereoisomer 1)::US9388149, 2 (Enantiomer 2 of diastereoisomer 1)::US9580412, Example 2 C-X-C chemokine receptor type 1 Human 77.0 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236795 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7515&target=C-X-C+chemokine+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236795&enzyme=C-X-C+chemokine+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 129012361 340130375 1 MSNITDPQMWDFDDLNFTGMPPADEDYSPCMLETETLNKYVVIIAYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGCWGLSMNLSLPFFLFRQAYHPNNSSPVCYEVLGNDTAKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQESCERRNNIGRALDATEILGFLHSCLNPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHRVTSYTSSSVNVSSNL 8IC0,2LNL C-X-C chemokine receptor type 1 CXCR1_HUMAN P25024 B2R6Q3 Q2YEF8 Q2YEG4 Q2YEG5 Q2YEG7 Q2YEG8 Q53R18 Q6IN95 Q8N6T6 Q9P2T8 Q9P2T9 Q9P2U0 Q9P2U1 Q9P2U2 555231 CN(C)C(=O)c1cccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O InChI=1S/C23H25N3O5S/c1-12-9-10-15(31-12)17(16-8-5-11-32-16)25-19-18(21(28)22(19)29)24-14-7-4-6-13(20(14)27)23(30)26(2)3/h4,6-7,9-10,16-17,24-25,27H,5,8,11H2,1-3H3 KCVWGCOBGFLUEB-UHFFFAOYSA-N 236795 US9388149, 2 (Enantiomer 1 of diastereoisomer 2)::US9388149, 2 (Enantiomer 2 of diastereoisomer 2)::US9388149, 2 (Enantiomer 1 of diastereoisomer 1)::US9388149, 2 (Diastereoisomer 2)::US9388149, 2 (Diastereoisomer 1)::US9388149, 2 (Enantiomer 2 of diastereoisomer 1)::US9580412, Example 2 C-X-C chemokine receptor type 2 Human 15.0 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236795 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5556&target=C-X-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236795&enzyme=C-X-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 129012361 340130375 1 MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL 6LFO,6LFM,8XXX,8XXR,8XXH,8XX7,8XX6,8XX3,8XWV,8XWS,8XWN,8XWM,8XWF,8XWA,8XVU C-X-C chemokine receptor type 2 CXCR2_HUMAN P25025 Q8IUZ1 Q9P2T6 Q9P2T7 555232 CN(C)C(=O)c1cccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O InChI=1S/C23H25N3O5S/c1-12-9-10-15(31-12)17(16-8-5-11-32-16)25-19-18(21(28)22(19)29)24-14-7-4-6-13(20(14)27)23(30)26(2)3/h4,6-7,9-10,16-17,24-25,27H,5,8,11H2,1-3H3 KCVWGCOBGFLUEB-UHFFFAOYSA-N 236795 US9388149, 2 (Enantiomer 1 of diastereoisomer 2)::US9388149, 2 (Enantiomer 2 of diastereoisomer 2)::US9388149, 2 (Enantiomer 1 of diastereoisomer 1)::US9388149, 2 (Diastereoisomer 2)::US9388149, 2 (Diastereoisomer 1)::US9388149, 2 (Enantiomer 2 of diastereoisomer 1)::US9580412, Example 2 C-X-C chemokine receptor type 1 Human 4554 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236795 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7515&target=C-X-C+chemokine+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236795&enzyme=C-X-C+chemokine+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 129012361 340130375 1 MSNITDPQMWDFDDLNFTGMPPADEDYSPCMLETETLNKYVVIIAYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGCWGLSMNLSLPFFLFRQAYHPNNSSPVCYEVLGNDTAKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQESCERRNNIGRALDATEILGFLHSCLNPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHRVTSYTSSSVNVSSNL 8IC0,2LNL C-X-C chemokine receptor type 1 CXCR1_HUMAN P25024 B2R6Q3 Q2YEF8 Q2YEG4 Q2YEG5 Q2YEG7 Q2YEG8 Q53R18 Q6IN95 Q8N6T6 Q9P2T8 Q9P2T9 Q9P2U0 Q9P2U1 Q9P2U2 555233 CN(C)C(=O)c1cccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O InChI=1S/C23H25N3O5S/c1-12-9-10-15(31-12)17(16-8-5-11-32-16)25-19-18(21(28)22(19)29)24-14-7-4-6-13(20(14)27)23(30)26(2)3/h4,6-7,9-10,16-17,24-25,27H,5,8,11H2,1-3H3 KCVWGCOBGFLUEB-UHFFFAOYSA-N 236795 US9388149, 2 (Enantiomer 1 of diastereoisomer 2)::US9388149, 2 (Enantiomer 2 of diastereoisomer 2)::US9388149, 2 (Enantiomer 1 of diastereoisomer 1)::US9388149, 2 (Diastereoisomer 2)::US9388149, 2 (Diastereoisomer 1)::US9388149, 2 (Enantiomer 2 of diastereoisomer 1)::US9580412, Example 2 C-X-C chemokine receptor type 2 Human 273 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236795 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5556&target=C-X-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236795&enzyme=C-X-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 129012361 340130375 1 MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL 6LFO,6LFM,8XXX,8XXR,8XXH,8XX7,8XX6,8XX3,8XWV,8XWS,8XWN,8XWM,8XWF,8XWA,8XVU C-X-C chemokine receptor type 2 CXCR2_HUMAN P25025 Q8IUZ1 Q9P2T6 Q9P2T7 555234 CN(C)C(=O)c1cccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O InChI=1S/C23H25N3O5S/c1-12-9-10-15(31-12)17(16-8-5-11-32-16)25-19-18(21(28)22(19)29)24-14-7-4-6-13(20(14)27)23(30)26(2)3/h4,6-7,9-10,16-17,24-25,27H,5,8,11H2,1-3H3 KCVWGCOBGFLUEB-UHFFFAOYSA-N 236795 US9388149, 2 (Enantiomer 1 of diastereoisomer 2)::US9388149, 2 (Enantiomer 2 of diastereoisomer 2)::US9388149, 2 (Enantiomer 1 of diastereoisomer 1)::US9388149, 2 (Diastereoisomer 2)::US9388149, 2 (Diastereoisomer 1)::US9388149, 2 (Enantiomer 2 of diastereoisomer 1)::US9580412, Example 2 C-X-C chemokine receptor type 1 Human 4554 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236795 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7515&target=C-X-C+chemokine+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236795&enzyme=C-X-C+chemokine+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 129012361 340130375 1 MSNITDPQMWDFDDLNFTGMPPADEDYSPCMLETETLNKYVVIIAYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGCWGLSMNLSLPFFLFRQAYHPNNSSPVCYEVLGNDTAKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQESCERRNNIGRALDATEILGFLHSCLNPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHRVTSYTSSSVNVSSNL 8IC0,2LNL C-X-C chemokine receptor type 1 CXCR1_HUMAN P25024 B2R6Q3 Q2YEF8 Q2YEG4 Q2YEG5 Q2YEG7 Q2YEG8 Q53R18 Q6IN95 Q8N6T6 Q9P2T8 Q9P2T9 Q9P2U0 Q9P2U1 Q9P2U2 555235 CN(C)C(=O)c1cccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O InChI=1S/C23H25N3O5S/c1-12-9-10-15(31-12)17(16-8-5-11-32-16)25-19-18(21(28)22(19)29)24-14-7-4-6-13(20(14)27)23(30)26(2)3/h4,6-7,9-10,16-17,24-25,27H,5,8,11H2,1-3H3 KCVWGCOBGFLUEB-UHFFFAOYSA-N 236795 US9388149, 2 (Enantiomer 1 of diastereoisomer 2)::US9388149, 2 (Enantiomer 2 of diastereoisomer 2)::US9388149, 2 (Enantiomer 1 of diastereoisomer 1)::US9388149, 2 (Diastereoisomer 2)::US9388149, 2 (Diastereoisomer 1)::US9388149, 2 (Enantiomer 2 of diastereoisomer 1)::US9580412, Example 2 C-X-C chemokine receptor type 2 Human 273 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236795 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5556&target=C-X-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236795&enzyme=C-X-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 129012361 340130375 1 MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL 6LFO,6LFM,8XXX,8XXR,8XXH,8XX7,8XX6,8XX3,8XWV,8XWS,8XWN,8XWM,8XWF,8XWA,8XVU C-X-C chemokine receptor type 2 CXCR2_HUMAN P25025 Q8IUZ1 Q9P2T6 Q9P2T7 555236 CN(C)C(=O)c1cccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O InChI=1S/C23H25N3O5S/c1-12-9-10-15(31-12)17(16-8-5-11-32-16)25-19-18(21(28)22(19)29)24-14-7-4-6-13(20(14)27)23(30)26(2)3/h4,6-7,9-10,16-17,24-25,27H,5,8,11H2,1-3H3 KCVWGCOBGFLUEB-UHFFFAOYSA-N 236795 US9388149, 2 (Enantiomer 1 of diastereoisomer 2)::US9388149, 2 (Enantiomer 2 of diastereoisomer 2)::US9388149, 2 (Enantiomer 1 of diastereoisomer 1)::US9388149, 2 (Diastereoisomer 2)::US9388149, 2 (Diastereoisomer 1)::US9388149, 2 (Enantiomer 2 of diastereoisomer 1)::US9580412, Example 2 C-X-C chemokine receptor type 1 Human 4554 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236795 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7515&target=C-X-C+chemokine+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236795&enzyme=C-X-C+chemokine+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 129012361 340130375 1 MSNITDPQMWDFDDLNFTGMPPADEDYSPCMLETETLNKYVVIIAYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGCWGLSMNLSLPFFLFRQAYHPNNSSPVCYEVLGNDTAKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQESCERRNNIGRALDATEILGFLHSCLNPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHRVTSYTSSSVNVSSNL 8IC0,2LNL C-X-C chemokine receptor type 1 CXCR1_HUMAN P25024 B2R6Q3 Q2YEF8 Q2YEG4 Q2YEG5 Q2YEG7 Q2YEG8 Q53R18 Q6IN95 Q8N6T6 Q9P2T8 Q9P2T9 Q9P2U0 Q9P2U1 Q9P2U2 555237 CN(C)C(=O)c1cccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O InChI=1S/C23H25N3O5S/c1-12-9-10-15(31-12)17(16-8-5-11-32-16)25-19-18(21(28)22(19)29)24-14-7-4-6-13(20(14)27)23(30)26(2)3/h4,6-7,9-10,16-17,24-25,27H,5,8,11H2,1-3H3 KCVWGCOBGFLUEB-UHFFFAOYSA-N 236795 US9388149, 2 (Enantiomer 1 of diastereoisomer 2)::US9388149, 2 (Enantiomer 2 of diastereoisomer 2)::US9388149, 2 (Enantiomer 1 of diastereoisomer 1)::US9388149, 2 (Diastereoisomer 2)::US9388149, 2 (Diastereoisomer 1)::US9388149, 2 (Enantiomer 2 of diastereoisomer 1)::US9580412, Example 2 C-X-C chemokine receptor type 2 Human 273 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236795 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5556&target=C-X-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236795&enzyme=C-X-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 129012361 340130375 1 MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL 6LFO,6LFM,8XXX,8XXR,8XXH,8XX7,8XX6,8XX3,8XWV,8XWS,8XWN,8XWM,8XWF,8XWA,8XVU C-X-C chemokine receptor type 2 CXCR2_HUMAN P25025 Q8IUZ1 Q9P2T6 Q9P2T7 555238 CN(C)C(=O)c1cccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O InChI=1S/C23H25N3O5S/c1-12-9-10-15(31-12)17(16-8-5-11-32-16)25-19-18(21(28)22(19)29)24-14-7-4-6-13(20(14)27)23(30)26(2)3/h4,6-7,9-10,16-17,24-25,27H,5,8,11H2,1-3H3 KCVWGCOBGFLUEB-UHFFFAOYSA-N 236795 US9388149, 2 (Enantiomer 1 of diastereoisomer 2)::US9388149, 2 (Enantiomer 2 of diastereoisomer 2)::US9388149, 2 (Enantiomer 1 of diastereoisomer 1)::US9388149, 2 (Diastereoisomer 2)::US9388149, 2 (Diastereoisomer 1)::US9388149, 2 (Enantiomer 2 of diastereoisomer 1)::US9580412, Example 2 C-X-C chemokine receptor type 1 Human 4554 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236795 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7515&target=C-X-C+chemokine+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236795&enzyme=C-X-C+chemokine+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 129012361 340130375 1 MSNITDPQMWDFDDLNFTGMPPADEDYSPCMLETETLNKYVVIIAYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGCWGLSMNLSLPFFLFRQAYHPNNSSPVCYEVLGNDTAKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQESCERRNNIGRALDATEILGFLHSCLNPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHRVTSYTSSSVNVSSNL 8IC0,2LNL C-X-C chemokine receptor type 1 CXCR1_HUMAN P25024 B2R6Q3 Q2YEF8 Q2YEG4 Q2YEG5 Q2YEG7 Q2YEG8 Q53R18 Q6IN95 Q8N6T6 Q9P2T8 Q9P2T9 Q9P2U0 Q9P2U1 Q9P2U2 555239 CN(C)C(=O)c1cccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O InChI=1S/C23H25N3O5S/c1-12-9-10-15(31-12)17(16-8-5-11-32-16)25-19-18(21(28)22(19)29)24-14-7-4-6-13(20(14)27)23(30)26(2)3/h4,6-7,9-10,16-17,24-25,27H,5,8,11H2,1-3H3 KCVWGCOBGFLUEB-UHFFFAOYSA-N 236795 US9388149, 2 (Enantiomer 1 of diastereoisomer 2)::US9388149, 2 (Enantiomer 2 of diastereoisomer 2)::US9388149, 2 (Enantiomer 1 of diastereoisomer 1)::US9388149, 2 (Diastereoisomer 2)::US9388149, 2 (Diastereoisomer 1)::US9388149, 2 (Enantiomer 2 of diastereoisomer 1)::US9580412, Example 2 C-X-C chemokine receptor type 2 Human 273 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236795 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5556&target=C-X-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236795&enzyme=C-X-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 129012361 340130375 1 MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL 6LFO,6LFM,8XXX,8XXR,8XXH,8XX7,8XX6,8XX3,8XWV,8XWS,8XWN,8XWM,8XWF,8XWA,8XVU C-X-C chemokine receptor type 2 CXCR2_HUMAN P25025 Q8IUZ1 Q9P2T6 Q9P2T7 555240 CN(C)C(=O)c1cccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O InChI=1S/C23H25N3O5S/c1-12-9-10-15(31-12)17(16-8-5-11-32-16)25-19-18(21(28)22(19)29)24-14-7-4-6-13(20(14)27)23(30)26(2)3/h4,6-7,9-10,16-17,24-25,27H,5,8,11H2,1-3H3 KCVWGCOBGFLUEB-UHFFFAOYSA-N 236795 US9388149, 2 (Enantiomer 1 of diastereoisomer 2)::US9388149, 2 (Enantiomer 2 of diastereoisomer 2)::US9388149, 2 (Enantiomer 1 of diastereoisomer 1)::US9388149, 2 (Diastereoisomer 2)::US9388149, 2 (Diastereoisomer 1)::US9388149, 2 (Enantiomer 2 of diastereoisomer 1)::US9580412, Example 2 C-X-C chemokine receptor type 1 Human 4554 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236795 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7515&target=C-X-C+chemokine+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236795&enzyme=C-X-C+chemokine+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 129012361 340130375 1 MSNITDPQMWDFDDLNFTGMPPADEDYSPCMLETETLNKYVVIIAYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGCWGLSMNLSLPFFLFRQAYHPNNSSPVCYEVLGNDTAKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQESCERRNNIGRALDATEILGFLHSCLNPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHRVTSYTSSSVNVSSNL 8IC0,2LNL C-X-C chemokine receptor type 1 CXCR1_HUMAN P25024 B2R6Q3 Q2YEF8 Q2YEG4 Q2YEG5 Q2YEG7 Q2YEG8 Q53R18 Q6IN95 Q8N6T6 Q9P2T8 Q9P2T9 Q9P2U0 Q9P2U1 Q9P2U2 555241 CN(C)C(=O)c1cccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O InChI=1S/C23H25N3O5S/c1-12-9-10-15(31-12)17(16-8-5-11-32-16)25-19-18(21(28)22(19)29)24-14-7-4-6-13(20(14)27)23(30)26(2)3/h4,6-7,9-10,16-17,24-25,27H,5,8,11H2,1-3H3 KCVWGCOBGFLUEB-UHFFFAOYSA-N 236795 US9388149, 2 (Enantiomer 1 of diastereoisomer 2)::US9388149, 2 (Enantiomer 2 of diastereoisomer 2)::US9388149, 2 (Enantiomer 1 of diastereoisomer 1)::US9388149, 2 (Diastereoisomer 2)::US9388149, 2 (Diastereoisomer 1)::US9388149, 2 (Enantiomer 2 of diastereoisomer 1)::US9580412, Example 2 C-X-C chemokine receptor type 2 Human 273 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236795 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5556&target=C-X-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236795&enzyme=C-X-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 129012361 340130375 1 MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL 6LFO,6LFM,8XXX,8XXR,8XXH,8XX7,8XX6,8XX3,8XWV,8XWS,8XWN,8XWM,8XWF,8XWA,8XVU C-X-C chemokine receptor type 2 CXCR2_HUMAN P25025 Q8IUZ1 Q9P2T6 Q9P2T7 555242 COC(=O)[C@@H]1CCCN1C(=O)c1cccc(Nc2c(NC([C@@H]3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1F |r,w:20.27| InChI=1S/C27H28FN3O6S/c1-14-10-11-18(37-14)21(19-9-5-13-38-19)30-23-22(24(32)25(23)33)29-16-7-3-6-15(20(16)28)26(34)31-12-4-8-17(31)27(35)36-2/h3,6-7,10-11,17,19,21,29-30H,4-5,8-9,12-13H2,1-2H3 OISJPBYRKOJZRI-UHFFFAOYSA-N 291174 methyl (S)-1-[2-fluoro-3-(2-{[(5-methylfuran-2-yl)-(tetrahydrothiophen-2-yl)methyl]amino}-3,4-dioxocyclobut-1-enylamino)benzoyl]pyrrolidine-2-carboxylate::US9580412, Example 3 C-X-C chemokine receptor type 1 Human 552 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291174 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7515&target=C-X-C+chemokine+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291174&enzyme=C-X-C+chemokine+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 137528692 381611480 1 MSNITDPQMWDFDDLNFTGMPPADEDYSPCMLETETLNKYVVIIAYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGCWGLSMNLSLPFFLFRQAYHPNNSSPVCYEVLGNDTAKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQESCERRNNIGRALDATEILGFLHSCLNPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHRVTSYTSSSVNVSSNL 8IC0,2LNL C-X-C chemokine receptor type 1 CXCR1_HUMAN P25024 B2R6Q3 Q2YEF8 Q2YEG4 Q2YEG5 Q2YEG7 Q2YEG8 Q53R18 Q6IN95 Q8N6T6 Q9P2T8 Q9P2T9 Q9P2U0 Q9P2U1 Q9P2U2 555243 COC(=O)[C@@H]1CCCN1C(=O)c1cccc(Nc2c(NC([C@@H]3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1F |r,w:20.27| InChI=1S/C27H28FN3O6S/c1-14-10-11-18(37-14)21(19-9-5-13-38-19)30-23-22(24(32)25(23)33)29-16-7-3-6-15(20(16)28)26(34)31-12-4-8-17(31)27(35)36-2/h3,6-7,10-11,17,19,21,29-30H,4-5,8-9,12-13H2,1-2H3 OISJPBYRKOJZRI-UHFFFAOYSA-N 291174 methyl (S)-1-[2-fluoro-3-(2-{[(5-methylfuran-2-yl)-(tetrahydrothiophen-2-yl)methyl]amino}-3,4-dioxocyclobut-1-enylamino)benzoyl]pyrrolidine-2-carboxylate::US9580412, Example 3 C-X-C chemokine receptor type 2 Human 195 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291174 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5556&target=C-X-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291174&enzyme=C-X-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 137528692 381611480 1 MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL 6LFO,6LFM,8XXX,8XXR,8XXH,8XX7,8XX6,8XX3,8XWV,8XWS,8XWN,8XWM,8XWF,8XWA,8XVU C-X-C chemokine receptor type 2 CXCR2_HUMAN P25025 Q8IUZ1 Q9P2T6 Q9P2T7 555244 COC(=O)[C@@H]1CCCN1C(=O)c1cccc(Nc2c(NC([C@@H]3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1F |r,w:20.27| InChI=1S/C27H28FN3O6S/c1-14-10-11-18(37-14)21(19-9-5-13-38-19)30-23-22(24(32)25(23)33)29-16-7-3-6-15(20(16)28)26(34)31-12-4-8-17(31)27(35)36-2/h3,6-7,10-11,17,19,21,29-30H,4-5,8-9,12-13H2,1-2H3 OISJPBYRKOJZRI-UHFFFAOYSA-N 291174 methyl (S)-1-[2-fluoro-3-(2-{[(5-methylfuran-2-yl)-(tetrahydrothiophen-2-yl)methyl]amino}-3,4-dioxocyclobut-1-enylamino)benzoyl]pyrrolidine-2-carboxylate::US9580412, Example 3 C-X-C chemokine receptor type 1 Human 8907 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291174 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7515&target=C-X-C+chemokine+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291174&enzyme=C-X-C+chemokine+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 137528692 381611480 1 MSNITDPQMWDFDDLNFTGMPPADEDYSPCMLETETLNKYVVIIAYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGCWGLSMNLSLPFFLFRQAYHPNNSSPVCYEVLGNDTAKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQESCERRNNIGRALDATEILGFLHSCLNPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHRVTSYTSSSVNVSSNL 8IC0,2LNL C-X-C chemokine receptor type 1 CXCR1_HUMAN P25024 B2R6Q3 Q2YEF8 Q2YEG4 Q2YEG5 Q2YEG7 Q2YEG8 Q53R18 Q6IN95 Q8N6T6 Q9P2T8 Q9P2T9 Q9P2U0 Q9P2U1 Q9P2U2 555245 COC(=O)[C@@H]1CCCN1C(=O)c1cccc(Nc2c(NC([C@@H]3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1F |r,w:20.27| InChI=1S/C27H28FN3O6S/c1-14-10-11-18(37-14)21(19-9-5-13-38-19)30-23-22(24(32)25(23)33)29-16-7-3-6-15(20(16)28)26(34)31-12-4-8-17(31)27(35)36-2/h3,6-7,10-11,17,19,21,29-30H,4-5,8-9,12-13H2,1-2H3 OISJPBYRKOJZRI-UHFFFAOYSA-N 291174 methyl (S)-1-[2-fluoro-3-(2-{[(5-methylfuran-2-yl)-(tetrahydrothiophen-2-yl)methyl]amino}-3,4-dioxocyclobut-1-enylamino)benzoyl]pyrrolidine-2-carboxylate::US9580412, Example 3 C-X-C chemokine receptor type 2 Human 982 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291174 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5556&target=C-X-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291174&enzyme=C-X-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 137528692 381611480 1 MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL 6LFO,6LFM,8XXX,8XXR,8XXH,8XX7,8XX6,8XX3,8XWV,8XWS,8XWN,8XWM,8XWF,8XWA,8XVU C-X-C chemokine receptor type 2 CXCR2_HUMAN P25025 Q8IUZ1 Q9P2T6 Q9P2T7 555246 COC(=O)[C@@H]1CCCN1C(=O)c1cccc(Nc2c(NC([C@@H]3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1F |r,w:20.27| InChI=1S/C27H28FN3O6S/c1-14-10-11-18(37-14)21(19-9-5-13-38-19)30-23-22(24(32)25(23)33)29-16-7-3-6-15(20(16)28)26(34)31-12-4-8-17(31)27(35)36-2/h3,6-7,10-11,17,19,21,29-30H,4-5,8-9,12-13H2,1-2H3 OISJPBYRKOJZRI-UHFFFAOYSA-N 291174 methyl (S)-1-[2-fluoro-3-(2-{[(5-methylfuran-2-yl)-(tetrahydrothiophen-2-yl)methyl]amino}-3,4-dioxocyclobut-1-enylamino)benzoyl]pyrrolidine-2-carboxylate::US9580412, Example 3 C-X-C chemokine receptor type 1 Human 8907 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291174 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7515&target=C-X-C+chemokine+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291174&enzyme=C-X-C+chemokine+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 137528692 381611480 1 MSNITDPQMWDFDDLNFTGMPPADEDYSPCMLETETLNKYVVIIAYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGCWGLSMNLSLPFFLFRQAYHPNNSSPVCYEVLGNDTAKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQESCERRNNIGRALDATEILGFLHSCLNPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHRVTSYTSSSVNVSSNL 8IC0,2LNL C-X-C chemokine receptor type 1 CXCR1_HUMAN P25024 B2R6Q3 Q2YEF8 Q2YEG4 Q2YEG5 Q2YEG7 Q2YEG8 Q53R18 Q6IN95 Q8N6T6 Q9P2T8 Q9P2T9 Q9P2U0 Q9P2U1 Q9P2U2 555247 COC(=O)[C@@H]1CCCN1C(=O)c1cccc(Nc2c(NC([C@@H]3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1F |r,w:20.27| InChI=1S/C27H28FN3O6S/c1-14-10-11-18(37-14)21(19-9-5-13-38-19)30-23-22(24(32)25(23)33)29-16-7-3-6-15(20(16)28)26(34)31-12-4-8-17(31)27(35)36-2/h3,6-7,10-11,17,19,21,29-30H,4-5,8-9,12-13H2,1-2H3 OISJPBYRKOJZRI-UHFFFAOYSA-N 291174 methyl (S)-1-[2-fluoro-3-(2-{[(5-methylfuran-2-yl)-(tetrahydrothiophen-2-yl)methyl]amino}-3,4-dioxocyclobut-1-enylamino)benzoyl]pyrrolidine-2-carboxylate::US9580412, Example 3 C-X-C chemokine receptor type 2 Human 982 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291174 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5556&target=C-X-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291174&enzyme=C-X-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 137528692 381611480 1 MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL 6LFO,6LFM,8XXX,8XXR,8XXH,8XX7,8XX6,8XX3,8XWV,8XWS,8XWN,8XWM,8XWF,8XWA,8XVU C-X-C chemokine receptor type 2 CXCR2_HUMAN P25025 Q8IUZ1 Q9P2T6 Q9P2T7 555248 CC(C)OC(=O)[C@@H]1CCCN1C(=O)c1cccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1F InChI=1S/C29H32FN3O6S/c1-15(2)38-29(37)19-9-5-13-33(19)28(36)17-7-4-8-18(22(17)30)31-24-25(27(35)26(24)34)32-23(21-10-6-14-40-21)20-12-11-16(3)39-20/h4,7-8,11-12,15,19,21,23,31-32H,5-6,9-10,13-14H2,1-3H3 AFOYTVCGGOVKKI-UHFFFAOYSA-N 236804 US9388149, 4::US9580412, Example 4 C-X-C chemokine receptor type 1 Human 1892 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236804 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7515&target=C-X-C+chemokine+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236804&enzyme=C-X-C+chemokine+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 129012365 340130379 1 MSNITDPQMWDFDDLNFTGMPPADEDYSPCMLETETLNKYVVIIAYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGCWGLSMNLSLPFFLFRQAYHPNNSSPVCYEVLGNDTAKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQESCERRNNIGRALDATEILGFLHSCLNPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHRVTSYTSSSVNVSSNL 8IC0,2LNL C-X-C chemokine receptor type 1 CXCR1_HUMAN P25024 B2R6Q3 Q2YEF8 Q2YEG4 Q2YEG5 Q2YEG7 Q2YEG8 Q53R18 Q6IN95 Q8N6T6 Q9P2T8 Q9P2T9 Q9P2U0 Q9P2U1 Q9P2U2 555249 CC(C)OC(=O)[C@@H]1CCCN1C(=O)c1cccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1F InChI=1S/C29H32FN3O6S/c1-15(2)38-29(37)19-9-5-13-33(19)28(36)17-7-4-8-18(22(17)30)31-24-25(27(35)26(24)34)32-23(21-10-6-14-40-21)20-12-11-16(3)39-20/h4,7-8,11-12,15,19,21,23,31-32H,5-6,9-10,13-14H2,1-3H3 AFOYTVCGGOVKKI-UHFFFAOYSA-N 236804 US9388149, 4::US9580412, Example 4 C-X-C chemokine receptor type 2 Human 109 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236804 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5556&target=C-X-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236804&enzyme=C-X-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 129012365 340130379 1 MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL 6LFO,6LFM,8XXX,8XXR,8XXH,8XX7,8XX6,8XX3,8XWV,8XWS,8XWN,8XWM,8XWF,8XWA,8XVU C-X-C chemokine receptor type 2 CXCR2_HUMAN P25025 Q8IUZ1 Q9P2T6 Q9P2T7 555250 CCOC(=O)[C@@H]1CCCN1C(=O)c1cccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1F InChI=1S/C28H30FN3O6S/c1-3-37-28(36)18-9-5-13-32(18)27(35)16-7-4-8-17(21(16)29)30-23-24(26(34)25(23)33)31-22(20-10-6-14-39-20)19-12-11-15(2)38-19/h4,7-8,11-12,18,20,22,30-31H,3,5-6,9-10,13-14H2,1-2H3 SJWVRSVJDTUULR-UHFFFAOYSA-N 236805 US9388149, 5::US9580412, Example 5 C-X-C chemokine receptor type 1 Human 711 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236805 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7515&target=C-X-C+chemokine+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236805&enzyme=C-X-C+chemokine+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 129012366 340130380 1 MSNITDPQMWDFDDLNFTGMPPADEDYSPCMLETETLNKYVVIIAYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGCWGLSMNLSLPFFLFRQAYHPNNSSPVCYEVLGNDTAKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQESCERRNNIGRALDATEILGFLHSCLNPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHRVTSYTSSSVNVSSNL 8IC0,2LNL C-X-C chemokine receptor type 1 CXCR1_HUMAN P25024 B2R6Q3 Q2YEF8 Q2YEG4 Q2YEG5 Q2YEG7 Q2YEG8 Q53R18 Q6IN95 Q8N6T6 Q9P2T8 Q9P2T9 Q9P2U0 Q9P2U1 Q9P2U2 555251 CCOC(=O)[C@@H]1CCCN1C(=O)c1cccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1F InChI=1S/C28H30FN3O6S/c1-3-37-28(36)18-9-5-13-32(18)27(35)16-7-4-8-17(21(16)29)30-23-24(26(34)25(23)33)31-22(20-10-6-14-39-20)19-12-11-15(2)38-19/h4,7-8,11-12,18,20,22,30-31H,3,5-6,9-10,13-14H2,1-2H3 SJWVRSVJDTUULR-UHFFFAOYSA-N 236805 US9388149, 5::US9580412, Example 5 C-X-C chemokine receptor type 2 Human 106 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236805 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5556&target=C-X-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236805&enzyme=C-X-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 129012366 340130380 1 MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL 6LFO,6LFM,8XXX,8XXR,8XXH,8XX7,8XX6,8XX3,8XWV,8XWS,8XWN,8XWM,8XWF,8XWA,8XVU C-X-C chemokine receptor type 2 CXCR2_HUMAN P25025 Q8IUZ1 Q9P2T6 Q9P2T7 555252 COC(=O)[C@H]1CCCN1C(=O)c1cccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O |r| InChI=1S/C27H29N3O7S/c1-14-10-11-18(37-14)20(19-9-5-13-38-19)29-22-21(24(32)25(22)33)28-16-7-3-6-15(23(16)31)26(34)30-12-4-8-17(30)27(35)36-2/h3,6-7,10-11,17,19-20,28-29,31H,4-5,8-9,12-13H2,1-2H3 HDQNDRCZSVEGSG-UHFFFAOYSA-N 291177 US9580412, Example 6::methyl (R)-1-[2-hydroxy-3-(2-{[(5-methylfuran-2-yl)-(tetrahydrothiophen-2-yl)methyl]amino}-3,4-dioxocyclobut-1-enylamino)benzoyl]pyrrolidine-2-carboxylate::US9580412, Example 7 C-X-C chemokine receptor type 1 Human 108 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291177 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7515&target=C-X-C+chemokine+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291177&enzyme=C-X-C+chemokine+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 129012357 381611483 1 MSNITDPQMWDFDDLNFTGMPPADEDYSPCMLETETLNKYVVIIAYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGCWGLSMNLSLPFFLFRQAYHPNNSSPVCYEVLGNDTAKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQESCERRNNIGRALDATEILGFLHSCLNPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHRVTSYTSSSVNVSSNL 8IC0,2LNL C-X-C chemokine receptor type 1 CXCR1_HUMAN P25024 B2R6Q3 Q2YEF8 Q2YEG4 Q2YEG5 Q2YEG7 Q2YEG8 Q53R18 Q6IN95 Q8N6T6 Q9P2T8 Q9P2T9 Q9P2U0 Q9P2U1 Q9P2U2 555253 COC(=O)[C@H]1CCCN1C(=O)c1cccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O |r| InChI=1S/C27H29N3O7S/c1-14-10-11-18(37-14)20(19-9-5-13-38-19)29-22-21(24(32)25(22)33)28-16-7-3-6-15(23(16)31)26(34)30-12-4-8-17(30)27(35)36-2/h3,6-7,10-11,17,19-20,28-29,31H,4-5,8-9,12-13H2,1-2H3 HDQNDRCZSVEGSG-UHFFFAOYSA-N 291177 US9580412, Example 6::methyl (R)-1-[2-hydroxy-3-(2-{[(5-methylfuran-2-yl)-(tetrahydrothiophen-2-yl)methyl]amino}-3,4-dioxocyclobut-1-enylamino)benzoyl]pyrrolidine-2-carboxylate::US9580412, Example 7 C-X-C chemokine receptor type 2 Human 30.0 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291177 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5556&target=C-X-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291177&enzyme=C-X-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 129012357 381611483 1 MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL 6LFO,6LFM,8XXX,8XXR,8XXH,8XX7,8XX6,8XX3,8XWV,8XWS,8XWN,8XWM,8XWF,8XWA,8XVU C-X-C chemokine receptor type 2 CXCR2_HUMAN P25025 Q8IUZ1 Q9P2T6 Q9P2T7 555254 COC(=O)[C@H]1CCCN1C(=O)c1cccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O |r| InChI=1S/C27H29N3O7S/c1-14-10-11-18(37-14)20(19-9-5-13-38-19)29-22-21(24(32)25(22)33)28-16-7-3-6-15(23(16)31)26(34)30-12-4-8-17(30)27(35)36-2/h3,6-7,10-11,17,19-20,28-29,31H,4-5,8-9,12-13H2,1-2H3 HDQNDRCZSVEGSG-UHFFFAOYSA-N 291177 US9580412, Example 6::methyl (R)-1-[2-hydroxy-3-(2-{[(5-methylfuran-2-yl)-(tetrahydrothiophen-2-yl)methyl]amino}-3,4-dioxocyclobut-1-enylamino)benzoyl]pyrrolidine-2-carboxylate::US9580412, Example 7 C-X-C chemokine receptor type 1 Human 171 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291177 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7515&target=C-X-C+chemokine+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291177&enzyme=C-X-C+chemokine+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 129012357 381611483 1 MSNITDPQMWDFDDLNFTGMPPADEDYSPCMLETETLNKYVVIIAYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGCWGLSMNLSLPFFLFRQAYHPNNSSPVCYEVLGNDTAKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQESCERRNNIGRALDATEILGFLHSCLNPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHRVTSYTSSSVNVSSNL 8IC0,2LNL C-X-C chemokine receptor type 1 CXCR1_HUMAN P25024 B2R6Q3 Q2YEF8 Q2YEG4 Q2YEG5 Q2YEG7 Q2YEG8 Q53R18 Q6IN95 Q8N6T6 Q9P2T8 Q9P2T9 Q9P2U0 Q9P2U1 Q9P2U2 555255 COC(=O)[C@H]1CCCN1C(=O)c1cccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O |r| InChI=1S/C27H29N3O7S/c1-14-10-11-18(37-14)20(19-9-5-13-38-19)29-22-21(24(32)25(22)33)28-16-7-3-6-15(23(16)31)26(34)30-12-4-8-17(30)27(35)36-2/h3,6-7,10-11,17,19-20,28-29,31H,4-5,8-9,12-13H2,1-2H3 HDQNDRCZSVEGSG-UHFFFAOYSA-N 291177 US9580412, Example 6::methyl (R)-1-[2-hydroxy-3-(2-{[(5-methylfuran-2-yl)-(tetrahydrothiophen-2-yl)methyl]amino}-3,4-dioxocyclobut-1-enylamino)benzoyl]pyrrolidine-2-carboxylate::US9580412, Example 7 C-X-C chemokine receptor type 2 Human 37.0 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291177 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5556&target=C-X-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291177&enzyme=C-X-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 129012357 381611483 1 MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL 6LFO,6LFM,8XXX,8XXR,8XXH,8XX7,8XX6,8XX3,8XWV,8XWS,8XWN,8XWM,8XWF,8XWA,8XVU C-X-C chemokine receptor type 2 CXCR2_HUMAN P25025 Q8IUZ1 Q9P2T6 Q9P2T7 555256 COC(=O)[C@H]1CCCN1C(=O)c1cccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O |r| InChI=1S/C27H29N3O7S/c1-14-10-11-18(37-14)20(19-9-5-13-38-19)29-22-21(24(32)25(22)33)28-16-7-3-6-15(23(16)31)26(34)30-12-4-8-17(30)27(35)36-2/h3,6-7,10-11,17,19-20,28-29,31H,4-5,8-9,12-13H2,1-2H3 HDQNDRCZSVEGSG-UHFFFAOYSA-N 291177 US9580412, Example 6::methyl (R)-1-[2-hydroxy-3-(2-{[(5-methylfuran-2-yl)-(tetrahydrothiophen-2-yl)methyl]amino}-3,4-dioxocyclobut-1-enylamino)benzoyl]pyrrolidine-2-carboxylate::US9580412, Example 7 C-X-C chemokine receptor type 1 Human 859 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291177 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7515&target=C-X-C+chemokine+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291177&enzyme=C-X-C+chemokine+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 129012357 381611483 1 MSNITDPQMWDFDDLNFTGMPPADEDYSPCMLETETLNKYVVIIAYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGCWGLSMNLSLPFFLFRQAYHPNNSSPVCYEVLGNDTAKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQESCERRNNIGRALDATEILGFLHSCLNPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHRVTSYTSSSVNVSSNL 8IC0,2LNL C-X-C chemokine receptor type 1 CXCR1_HUMAN P25024 B2R6Q3 Q2YEF8 Q2YEG4 Q2YEG5 Q2YEG7 Q2YEG8 Q53R18 Q6IN95 Q8N6T6 Q9P2T8 Q9P2T9 Q9P2U0 Q9P2U1 Q9P2U2 555257 COC(=O)[C@H]1CCCN1C(=O)c1cccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O |r| InChI=1S/C27H29N3O7S/c1-14-10-11-18(37-14)20(19-9-5-13-38-19)29-22-21(24(32)25(22)33)28-16-7-3-6-15(23(16)31)26(34)30-12-4-8-17(30)27(35)36-2/h3,6-7,10-11,17,19-20,28-29,31H,4-5,8-9,12-13H2,1-2H3 HDQNDRCZSVEGSG-UHFFFAOYSA-N 291177 US9580412, Example 6::methyl (R)-1-[2-hydroxy-3-(2-{[(5-methylfuran-2-yl)-(tetrahydrothiophen-2-yl)methyl]amino}-3,4-dioxocyclobut-1-enylamino)benzoyl]pyrrolidine-2-carboxylate::US9580412, Example 7 C-X-C chemokine receptor type 2 Human 86.0 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291177 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5556&target=C-X-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291177&enzyme=C-X-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 129012357 381611483 1 MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL 6LFO,6LFM,8XXX,8XXR,8XXH,8XX7,8XX6,8XX3,8XWV,8XWS,8XWN,8XWM,8XWF,8XWA,8XVU C-X-C chemokine receptor type 2 CXCR2_HUMAN P25025 Q8IUZ1 Q9P2T6 Q9P2T7 555258 CN(CC(F)(F)F)C(=O)c1cccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O InChI=1S/C24H24F3N3O5S/c1-12-8-9-15(35-12)17(16-7-4-10-36-16)29-19-18(21(32)22(19)33)28-14-6-3-5-13(20(14)31)23(34)30(2)11-24(25,26)27/h3,5-6,8-9,16-17,28-29,31H,4,7,10-11H2,1-2H3 KBLOFZHBIDLNIS-UHFFFAOYSA-N 291179 2-hydroxy-N-methyl-3-(2-{[(S)-(5-methylfuran-2-yl)tetrahydrothiophen-2-ylmethyl]amino}-3,4-dioxocyclobut-1-enylamino)-N-(2,2,2-trifluoroethyl)benzamide::US9580412, Example 8 C-X-C chemokine receptor type 1 Human 85.0 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291179 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7515&target=C-X-C+chemokine+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291179&enzyme=C-X-C+chemokine+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 137528693 381611484 1 MSNITDPQMWDFDDLNFTGMPPADEDYSPCMLETETLNKYVVIIAYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGCWGLSMNLSLPFFLFRQAYHPNNSSPVCYEVLGNDTAKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQESCERRNNIGRALDATEILGFLHSCLNPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHRVTSYTSSSVNVSSNL 8IC0,2LNL C-X-C chemokine receptor type 1 CXCR1_HUMAN P25024 B2R6Q3 Q2YEF8 Q2YEG4 Q2YEG5 Q2YEG7 Q2YEG8 Q53R18 Q6IN95 Q8N6T6 Q9P2T8 Q9P2T9 Q9P2U0 Q9P2U1 Q9P2U2 555259 CN(CC(F)(F)F)C(=O)c1cccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O InChI=1S/C24H24F3N3O5S/c1-12-8-9-15(35-12)17(16-7-4-10-36-16)29-19-18(21(32)22(19)33)28-14-6-3-5-13(20(14)31)23(34)30(2)11-24(25,26)27/h3,5-6,8-9,16-17,28-29,31H,4,7,10-11H2,1-2H3 KBLOFZHBIDLNIS-UHFFFAOYSA-N 291179 2-hydroxy-N-methyl-3-(2-{[(S)-(5-methylfuran-2-yl)tetrahydrothiophen-2-ylmethyl]amino}-3,4-dioxocyclobut-1-enylamino)-N-(2,2,2-trifluoroethyl)benzamide::US9580412, Example 8 C-X-C chemokine receptor type 2 Human 47.0 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291179 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5556&target=C-X-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291179&enzyme=C-X-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 137528693 381611484 1 MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL 6LFO,6LFM,8XXX,8XXR,8XXH,8XX7,8XX6,8XX3,8XWV,8XWS,8XWN,8XWM,8XWF,8XWA,8XVU C-X-C chemokine receptor type 2 CXCR2_HUMAN P25025 Q8IUZ1 Q9P2T6 Q9P2T7 555260 CN(CC(F)(F)F)C(=O)c1cccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O InChI=1S/C24H24F3N3O5S/c1-12-8-9-15(35-12)17(16-7-4-10-36-16)29-19-18(21(32)22(19)33)28-14-6-3-5-13(20(14)31)23(34)30(2)11-24(25,26)27/h3,5-6,8-9,16-17,28-29,31H,4,7,10-11H2,1-2H3 KBLOFZHBIDLNIS-UHFFFAOYSA-N 291179 2-hydroxy-N-methyl-3-(2-{[(S)-(5-methylfuran-2-yl)tetrahydrothiophen-2-ylmethyl]amino}-3,4-dioxocyclobut-1-enylamino)-N-(2,2,2-trifluoroethyl)benzamide::US9580412, Example 8 C-X-C chemokine receptor type 1 Human 508 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291179 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7515&target=C-X-C+chemokine+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291179&enzyme=C-X-C+chemokine+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 137528693 381611484 1 MSNITDPQMWDFDDLNFTGMPPADEDYSPCMLETETLNKYVVIIAYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGCWGLSMNLSLPFFLFRQAYHPNNSSPVCYEVLGNDTAKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQESCERRNNIGRALDATEILGFLHSCLNPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHRVTSYTSSSVNVSSNL 8IC0,2LNL C-X-C chemokine receptor type 1 CXCR1_HUMAN P25024 B2R6Q3 Q2YEF8 Q2YEG4 Q2YEG5 Q2YEG7 Q2YEG8 Q53R18 Q6IN95 Q8N6T6 Q9P2T8 Q9P2T9 Q9P2U0 Q9P2U1 Q9P2U2 555261 CN(CC(F)(F)F)C(=O)c1cccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O InChI=1S/C24H24F3N3O5S/c1-12-8-9-15(35-12)17(16-7-4-10-36-16)29-19-18(21(32)22(19)33)28-14-6-3-5-13(20(14)31)23(34)30(2)11-24(25,26)27/h3,5-6,8-9,16-17,28-29,31H,4,7,10-11H2,1-2H3 KBLOFZHBIDLNIS-UHFFFAOYSA-N 291179 2-hydroxy-N-methyl-3-(2-{[(S)-(5-methylfuran-2-yl)tetrahydrothiophen-2-ylmethyl]amino}-3,4-dioxocyclobut-1-enylamino)-N-(2,2,2-trifluoroethyl)benzamide::US9580412, Example 8 C-X-C chemokine receptor type 2 Human 115 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291179 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5556&target=C-X-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291179&enzyme=C-X-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 137528693 381611484 1 MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL 6LFO,6LFM,8XXX,8XXR,8XXH,8XX7,8XX6,8XX3,8XWV,8XWS,8XWN,8XWM,8XWF,8XWA,8XVU C-X-C chemokine receptor type 2 CXCR2_HUMAN P25025 Q8IUZ1 Q9P2T6 Q9P2T7 555262 COC(=O)CN(C)C(=O)c1cccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O InChI=1S/C25H27N3O7S/c1-13-9-10-16(35-13)19(17-8-5-11-36-17)27-21-20(23(31)24(21)32)26-15-7-4-6-14(22(15)30)25(33)28(2)12-18(29)34-3/h4,6-7,9-10,17,19,26-27,30H,5,8,11-12H2,1-3H3 JBBKREGWJICILL-UHFFFAOYSA-N 291180 methyl {[2-hydroxy-3-(2-{[(5-methylfuran-2-yl)-(tetrahydrothiophen-2-yl)methyl]amino}-3,4-dioxocyclobut-1-enylamino)benzoyl]methylamino}acetate::US9580412, Example 9 C-X-C chemokine receptor type 1 Human 89.0 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291180 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7515&target=C-X-C+chemokine+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291180&enzyme=C-X-C+chemokine+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 137528694 381611485 1 MSNITDPQMWDFDDLNFTGMPPADEDYSPCMLETETLNKYVVIIAYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGCWGLSMNLSLPFFLFRQAYHPNNSSPVCYEVLGNDTAKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQESCERRNNIGRALDATEILGFLHSCLNPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHRVTSYTSSSVNVSSNL 8IC0,2LNL C-X-C chemokine receptor type 1 CXCR1_HUMAN P25024 B2R6Q3 Q2YEF8 Q2YEG4 Q2YEG5 Q2YEG7 Q2YEG8 Q53R18 Q6IN95 Q8N6T6 Q9P2T8 Q9P2T9 Q9P2U0 Q9P2U1 Q9P2U2 555263 COC(=O)CN(C)C(=O)c1cccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O InChI=1S/C25H27N3O7S/c1-13-9-10-16(35-13)19(17-8-5-11-36-17)27-21-20(23(31)24(21)32)26-15-7-4-6-14(22(15)30)25(33)28(2)12-18(29)34-3/h4,6-7,9-10,17,19,26-27,30H,5,8,11-12H2,1-3H3 JBBKREGWJICILL-UHFFFAOYSA-N 291180 methyl {[2-hydroxy-3-(2-{[(5-methylfuran-2-yl)-(tetrahydrothiophen-2-yl)methyl]amino}-3,4-dioxocyclobut-1-enylamino)benzoyl]methylamino}acetate::US9580412, Example 9 C-X-C chemokine receptor type 2 Human 80.0 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291180 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5556&target=C-X-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291180&enzyme=C-X-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 137528694 381611485 1 MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL 6LFO,6LFM,8XXX,8XXR,8XXH,8XX7,8XX6,8XX3,8XWV,8XWS,8XWN,8XWM,8XWF,8XWA,8XVU C-X-C chemokine receptor type 2 CXCR2_HUMAN P25025 Q8IUZ1 Q9P2T6 Q9P2T7 555264 COC(=O)CN(C)C(=O)c1cccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O InChI=1S/C25H27N3O7S/c1-13-9-10-16(35-13)19(17-8-5-11-36-17)27-21-20(23(31)24(21)32)26-15-7-4-6-14(22(15)30)25(33)28(2)12-18(29)34-3/h4,6-7,9-10,17,19,26-27,30H,5,8,11-12H2,1-3H3 JBBKREGWJICILL-UHFFFAOYSA-N 291180 methyl {[2-hydroxy-3-(2-{[(5-methylfuran-2-yl)-(tetrahydrothiophen-2-yl)methyl]amino}-3,4-dioxocyclobut-1-enylamino)benzoyl]methylamino}acetate::US9580412, Example 9 C-X-C chemokine receptor type 1 Human 580 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291180 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7515&target=C-X-C+chemokine+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291180&enzyme=C-X-C+chemokine+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 137528694 381611485 1 MSNITDPQMWDFDDLNFTGMPPADEDYSPCMLETETLNKYVVIIAYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGCWGLSMNLSLPFFLFRQAYHPNNSSPVCYEVLGNDTAKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQESCERRNNIGRALDATEILGFLHSCLNPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHRVTSYTSSSVNVSSNL 8IC0,2LNL C-X-C chemokine receptor type 1 CXCR1_HUMAN P25024 B2R6Q3 Q2YEF8 Q2YEG4 Q2YEG5 Q2YEG7 Q2YEG8 Q53R18 Q6IN95 Q8N6T6 Q9P2T8 Q9P2T9 Q9P2U0 Q9P2U1 Q9P2U2 555265 COC(=O)CN(C)C(=O)c1cccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O InChI=1S/C25H27N3O7S/c1-13-9-10-16(35-13)19(17-8-5-11-36-17)27-21-20(23(31)24(21)32)26-15-7-4-6-14(22(15)30)25(33)28(2)12-18(29)34-3/h4,6-7,9-10,17,19,26-27,30H,5,8,11-12H2,1-3H3 JBBKREGWJICILL-UHFFFAOYSA-N 291180 methyl {[2-hydroxy-3-(2-{[(5-methylfuran-2-yl)-(tetrahydrothiophen-2-yl)methyl]amino}-3,4-dioxocyclobut-1-enylamino)benzoyl]methylamino}acetate::US9580412, Example 9 C-X-C chemokine receptor type 2 Human 153 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291180 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5556&target=C-X-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291180&enzyme=C-X-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 137528694 381611485 1 MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL 6LFO,6LFM,8XXX,8XXR,8XXH,8XX7,8XX6,8XX3,8XWV,8XWS,8XWN,8XWM,8XWF,8XWA,8XVU C-X-C chemokine receptor type 2 CXCR2_HUMAN P25025 Q8IUZ1 Q9P2T6 Q9P2T7 555266 CN(C)S(=O)(=O)c1cccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1C InChI=1S/C23H27N3O5S2/c1-13-10-11-16(31-13)19(17-8-6-12-32-17)25-21-20(22(27)23(21)28)24-15-7-5-9-18(14(15)2)33(29,30)26(3)4/h5,7,9-11,17,19,24-25H,6,8,12H2,1-4H3 DGPHJNJINCRCKW-UHFFFAOYSA-N 291181 6-chloro-2-hydroxy-N,N-dimethyl-3-(2-{[(5-methylfuran-2-yl)-(tetrahydrothiophen-2-yl)methyl]amino}-3,4-dioxocyclobut-1-enylamino)benzenesulfonamide::US9580412, Example 10 C-X-C chemokine receptor type 1 Human 20.0 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291181 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7515&target=C-X-C+chemokine+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291181&enzyme=C-X-C+chemokine+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 137528695 381611486 1 MSNITDPQMWDFDDLNFTGMPPADEDYSPCMLETETLNKYVVIIAYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGCWGLSMNLSLPFFLFRQAYHPNNSSPVCYEVLGNDTAKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQESCERRNNIGRALDATEILGFLHSCLNPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHRVTSYTSSSVNVSSNL 8IC0,2LNL C-X-C chemokine receptor type 1 CXCR1_HUMAN P25024 B2R6Q3 Q2YEF8 Q2YEG4 Q2YEG5 Q2YEG7 Q2YEG8 Q53R18 Q6IN95 Q8N6T6 Q9P2T8 Q9P2T9 Q9P2U0 Q9P2U1 Q9P2U2 555267 CN(C)S(=O)(=O)c1cccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1C InChI=1S/C23H27N3O5S2/c1-13-10-11-16(31-13)19(17-8-6-12-32-17)25-21-20(22(27)23(21)28)24-15-7-5-9-18(14(15)2)33(29,30)26(3)4/h5,7,9-11,17,19,24-25H,6,8,12H2,1-4H3 DGPHJNJINCRCKW-UHFFFAOYSA-N 291181 6-chloro-2-hydroxy-N,N-dimethyl-3-(2-{[(5-methylfuran-2-yl)-(tetrahydrothiophen-2-yl)methyl]amino}-3,4-dioxocyclobut-1-enylamino)benzenesulfonamide::US9580412, Example 10 C-X-C chemokine receptor type 2 Human 16.0 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291181 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5556&target=C-X-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291181&enzyme=C-X-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 137528695 381611486 1 MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL 6LFO,6LFM,8XXX,8XXR,8XXH,8XX7,8XX6,8XX3,8XWV,8XWS,8XWN,8XWM,8XWF,8XWA,8XVU C-X-C chemokine receptor type 2 CXCR2_HUMAN P25025 Q8IUZ1 Q9P2T6 Q9P2T7 555268 CN(C)S(=O)(=O)c1cccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1C InChI=1S/C23H27N3O5S2/c1-13-10-11-16(31-13)19(17-8-6-12-32-17)25-21-20(22(27)23(21)28)24-15-7-5-9-18(14(15)2)33(29,30)26(3)4/h5,7,9-11,17,19,24-25H,6,8,12H2,1-4H3 DGPHJNJINCRCKW-UHFFFAOYSA-N 291181 6-chloro-2-hydroxy-N,N-dimethyl-3-(2-{[(5-methylfuran-2-yl)-(tetrahydrothiophen-2-yl)methyl]amino}-3,4-dioxocyclobut-1-enylamino)benzenesulfonamide::US9580412, Example 10 C-X-C chemokine receptor type 1 Human 1096 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291181 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7515&target=C-X-C+chemokine+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291181&enzyme=C-X-C+chemokine+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 137528695 381611486 1 MSNITDPQMWDFDDLNFTGMPPADEDYSPCMLETETLNKYVVIIAYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGCWGLSMNLSLPFFLFRQAYHPNNSSPVCYEVLGNDTAKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQESCERRNNIGRALDATEILGFLHSCLNPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHRVTSYTSSSVNVSSNL 8IC0,2LNL C-X-C chemokine receptor type 1 CXCR1_HUMAN P25024 B2R6Q3 Q2YEF8 Q2YEG4 Q2YEG5 Q2YEG7 Q2YEG8 Q53R18 Q6IN95 Q8N6T6 Q9P2T8 Q9P2T9 Q9P2U0 Q9P2U1 Q9P2U2 555269 CN(C)S(=O)(=O)c1cccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1C InChI=1S/C23H27N3O5S2/c1-13-10-11-16(31-13)19(17-8-6-12-32-17)25-21-20(22(27)23(21)28)24-15-7-5-9-18(14(15)2)33(29,30)26(3)4/h5,7,9-11,17,19,24-25H,6,8,12H2,1-4H3 DGPHJNJINCRCKW-UHFFFAOYSA-N 291181 6-chloro-2-hydroxy-N,N-dimethyl-3-(2-{[(5-methylfuran-2-yl)-(tetrahydrothiophen-2-yl)methyl]amino}-3,4-dioxocyclobut-1-enylamino)benzenesulfonamide::US9580412, Example 10 C-X-C chemokine receptor type 2 Human 272 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291181 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5556&target=C-X-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291181&enzyme=C-X-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 137528695 381611486 1 MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL 6LFO,6LFM,8XXX,8XXR,8XXH,8XX7,8XX6,8XX3,8XWV,8XWS,8XWN,8XWM,8XWF,8XWA,8XVU C-X-C chemokine receptor type 2 CXCR2_HUMAN P25025 Q8IUZ1 Q9P2T6 Q9P2T7 555270 CN(C)C(=O)c1cccc(Nc2c(NC([C@H]3CCCO3)c3ccc(C)o3)c(=O)c2=O)c1O |r| InChI=1S/C23H25N3O6/c1-12-9-10-16(32-12)17(15-8-5-11-31-15)25-19-18(21(28)22(19)29)24-14-7-4-6-13(20(14)27)23(30)26(2)3/h4,6-7,9-10,15,17,24-25,27H,5,8,11H2,1-3H3 XEJUWHPWBDYKSK-UHFFFAOYSA-N 236780 US9388149, 11::US9580412, Example 11 C-X-C chemokine receptor type 1 Human 1322 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236780 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7515&target=C-X-C+chemokine+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236780&enzyme=C-X-C+chemokine+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 129012348 340130362 1 MSNITDPQMWDFDDLNFTGMPPADEDYSPCMLETETLNKYVVIIAYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGCWGLSMNLSLPFFLFRQAYHPNNSSPVCYEVLGNDTAKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQESCERRNNIGRALDATEILGFLHSCLNPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHRVTSYTSSSVNVSSNL 8IC0,2LNL C-X-C chemokine receptor type 1 CXCR1_HUMAN P25024 B2R6Q3 Q2YEF8 Q2YEG4 Q2YEG5 Q2YEG7 Q2YEG8 Q53R18 Q6IN95 Q8N6T6 Q9P2T8 Q9P2T9 Q9P2U0 Q9P2U1 Q9P2U2 555271 CN(C)C(=O)c1cccc(Nc2c(NC([C@H]3CCCO3)c3ccc(C)o3)c(=O)c2=O)c1O |r| InChI=1S/C23H25N3O6/c1-12-9-10-16(32-12)17(15-8-5-11-31-15)25-19-18(21(28)22(19)29)24-14-7-4-6-13(20(14)27)23(30)26(2)3/h4,6-7,9-10,15,17,24-25,27H,5,8,11H2,1-3H3 XEJUWHPWBDYKSK-UHFFFAOYSA-N 236780 US9388149, 11::US9580412, Example 11 C-X-C chemokine receptor type 2 Human 176 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236780 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5556&target=C-X-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236780&enzyme=C-X-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 129012348 340130362 1 MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL 6LFO,6LFM,8XXX,8XXR,8XXH,8XX7,8XX6,8XX3,8XWV,8XWS,8XWN,8XWM,8XWF,8XWA,8XVU C-X-C chemokine receptor type 2 CXCR2_HUMAN P25025 Q8IUZ1 Q9P2T6 Q9P2T7 555272 CN(C)C(=O)c1cccc(Nc2c(NC([C@@H]3CCCO3)c3ccc(C)o3)c(=O)c2=O)c1O |r| InChI=1S/C23H25N3O6/c1-12-9-10-16(32-12)17(15-8-5-11-31-15)25-19-18(21(28)22(19)29)24-14-7-4-6-13(20(14)27)23(30)26(2)3/h4,6-7,9-10,15,17,24-25,27H,5,8,11H2,1-3H3 XEJUWHPWBDYKSK-UHFFFAOYSA-N 236781 US9388149, 12::US9580412, Example 12 C-X-C chemokine receptor type 1 Human 483 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236781 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7515&target=C-X-C+chemokine+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236781&enzyme=C-X-C+chemokine+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 129012349 340130363 1 MSNITDPQMWDFDDLNFTGMPPADEDYSPCMLETETLNKYVVIIAYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGCWGLSMNLSLPFFLFRQAYHPNNSSPVCYEVLGNDTAKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQESCERRNNIGRALDATEILGFLHSCLNPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHRVTSYTSSSVNVSSNL 8IC0,2LNL C-X-C chemokine receptor type 1 CXCR1_HUMAN P25024 B2R6Q3 Q2YEF8 Q2YEG4 Q2YEG5 Q2YEG7 Q2YEG8 Q53R18 Q6IN95 Q8N6T6 Q9P2T8 Q9P2T9 Q9P2U0 Q9P2U1 Q9P2U2 555273 CN(C)C(=O)c1cccc(Nc2c(NC([C@@H]3CCCO3)c3ccc(C)o3)c(=O)c2=O)c1O |r| InChI=1S/C23H25N3O6/c1-12-9-10-16(32-12)17(15-8-5-11-31-15)25-19-18(21(28)22(19)29)24-14-7-4-6-13(20(14)27)23(30)26(2)3/h4,6-7,9-10,15,17,24-25,27H,5,8,11H2,1-3H3 XEJUWHPWBDYKSK-UHFFFAOYSA-N 236781 US9388149, 12::US9580412, Example 12 C-X-C chemokine receptor type 2 Human 83.0 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236781 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5556&target=C-X-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236781&enzyme=C-X-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 129012349 340130363 1 MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL 6LFO,6LFM,8XXX,8XXR,8XXH,8XX7,8XX6,8XX3,8XWV,8XWS,8XWN,8XWM,8XWF,8XWA,8XVU C-X-C chemokine receptor type 2 CXCR2_HUMAN P25025 Q8IUZ1 Q9P2T6 Q9P2T7 555274 CN(C)C(=O)c1cccc(Nc2c(NC(C3CCCO3)c3ccccc3)c(=O)c2=O)c1O InChI=1S/C24H25N3O5/c1-27(2)24(31)15-10-6-11-16(21(15)28)25-19-20(23(30)22(19)29)26-18(17-12-7-13-32-17)14-8-4-3-5-9-14/h3-6,8-11,17-18,25-26,28H,7,12-13H2,1-2H3 JBWWOFIQEXLSAB-UHFFFAOYSA-N 236782 US9388149, 13::US9580412, Example 13 C-X-C chemokine receptor type 1 Human 1148 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236782 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7515&target=C-X-C+chemokine+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236782&enzyme=C-X-C+chemokine+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 129012350 340130364 1 MSNITDPQMWDFDDLNFTGMPPADEDYSPCMLETETLNKYVVIIAYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGCWGLSMNLSLPFFLFRQAYHPNNSSPVCYEVLGNDTAKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQESCERRNNIGRALDATEILGFLHSCLNPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHRVTSYTSSSVNVSSNL 8IC0,2LNL C-X-C chemokine receptor type 1 CXCR1_HUMAN P25024 B2R6Q3 Q2YEF8 Q2YEG4 Q2YEG5 Q2YEG7 Q2YEG8 Q53R18 Q6IN95 Q8N6T6 Q9P2T8 Q9P2T9 Q9P2U0 Q9P2U1 Q9P2U2 555275 CN(C)C(=O)c1cccc(Nc2c(NC(C3CCCO3)c3ccccc3)c(=O)c2=O)c1O InChI=1S/C24H25N3O5/c1-27(2)24(31)15-10-6-11-16(21(15)28)25-19-20(23(30)22(19)29)26-18(17-12-7-13-32-17)14-8-4-3-5-9-14/h3-6,8-11,17-18,25-26,28H,7,12-13H2,1-2H3 JBWWOFIQEXLSAB-UHFFFAOYSA-N 236782 US9388149, 13::US9580412, Example 13 C-X-C chemokine receptor type 2 Human 170 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236782 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5556&target=C-X-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236782&enzyme=C-X-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 129012350 340130364 1 MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL 6LFO,6LFM,8XXX,8XXR,8XXH,8XX7,8XX6,8XX3,8XWV,8XWS,8XWN,8XWM,8XWF,8XWA,8XVU C-X-C chemokine receptor type 2 CXCR2_HUMAN P25025 Q8IUZ1 Q9P2T6 Q9P2T7 555276 CN(C)C(=O)c1cccc(Nc2c(NC([C@@H]3COC(C)(C)O3)c3ccc(C)o3)c(=O)c2=O)c1O |r| InChI=1S/C24H27N3O7/c1-12-9-10-15(33-12)17(16-11-32-24(2,3)34-16)26-19-18(21(29)22(19)30)25-14-8-6-7-13(20(14)28)23(31)27(4)5/h6-10,16-17,25-26,28H,11H2,1-5H3 BBFTWAOVJHOJQP-UHFFFAOYSA-N 236783 US9388149, 14 (Diastereoisomer 2)::US9580412, Example 14 C-X-C chemokine receptor type 1 Human 9999 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236783 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7515&target=C-X-C+chemokine+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236783&enzyme=C-X-C+chemokine+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 129012351 340130365 1 MSNITDPQMWDFDDLNFTGMPPADEDYSPCMLETETLNKYVVIIAYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGCWGLSMNLSLPFFLFRQAYHPNNSSPVCYEVLGNDTAKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQESCERRNNIGRALDATEILGFLHSCLNPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHRVTSYTSSSVNVSSNL 8IC0,2LNL C-X-C chemokine receptor type 1 CXCR1_HUMAN P25024 B2R6Q3 Q2YEF8 Q2YEG4 Q2YEG5 Q2YEG7 Q2YEG8 Q53R18 Q6IN95 Q8N6T6 Q9P2T8 Q9P2T9 Q9P2U0 Q9P2U1 Q9P2U2 555277 CN(C)C(=O)c1cccc(Nc2c(NC([C@@H]3COC(C)(C)O3)c3ccc(C)o3)c(=O)c2=O)c1O |r| InChI=1S/C24H27N3O7/c1-12-9-10-15(33-12)17(16-11-32-24(2,3)34-16)26-19-18(21(29)22(19)30)25-14-8-6-7-13(20(14)28)23(31)27(4)5/h6-10,16-17,25-26,28H,11H2,1-5H3 BBFTWAOVJHOJQP-UHFFFAOYSA-N 236783 US9388149, 14 (Diastereoisomer 2)::US9580412, Example 14 C-X-C chemokine receptor type 2 Human 1253 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236783 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5556&target=C-X-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236783&enzyme=C-X-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 129012351 340130365 1 MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL 6LFO,6LFM,8XXX,8XXR,8XXH,8XX7,8XX6,8XX3,8XWV,8XWS,8XWN,8XWM,8XWF,8XWA,8XVU C-X-C chemokine receptor type 2 CXCR2_HUMAN P25025 Q8IUZ1 Q9P2T6 Q9P2T7 555278 CN(C)C(=O)c1cccc(Nc2c(NC([C@@H]3COC(C)(C)O3)c3ccc(C)o3)c(=O)c2=O)c1O |r| InChI=1S/C24H27N3O7/c1-12-9-10-15(33-12)17(16-11-32-24(2,3)34-16)26-19-18(21(29)22(19)30)25-14-8-6-7-13(20(14)28)23(31)27(4)5/h6-10,16-17,25-26,28H,11H2,1-5H3 BBFTWAOVJHOJQP-UHFFFAOYSA-N 236783 US9388149, 14 (Diastereoisomer 2)::US9580412, Example 14 C-X-C chemokine receptor type 1 Human 9999 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236783 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7515&target=C-X-C+chemokine+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236783&enzyme=C-X-C+chemokine+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 129012351 340130365 1 MSNITDPQMWDFDDLNFTGMPPADEDYSPCMLETETLNKYVVIIAYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGCWGLSMNLSLPFFLFRQAYHPNNSSPVCYEVLGNDTAKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQESCERRNNIGRALDATEILGFLHSCLNPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHRVTSYTSSSVNVSSNL 8IC0,2LNL C-X-C chemokine receptor type 1 CXCR1_HUMAN P25024 B2R6Q3 Q2YEF8 Q2YEG4 Q2YEG5 Q2YEG7 Q2YEG8 Q53R18 Q6IN95 Q8N6T6 Q9P2T8 Q9P2T9 Q9P2U0 Q9P2U1 Q9P2U2 555279 CN(C)C(=O)c1cccc(Nc2c(NC([C@@H]3COC(C)(C)O3)c3ccc(C)o3)c(=O)c2=O)c1O |r| InChI=1S/C24H27N3O7/c1-12-9-10-15(33-12)17(16-11-32-24(2,3)34-16)26-19-18(21(29)22(19)30)25-14-8-6-7-13(20(14)28)23(31)27(4)5/h6-10,16-17,25-26,28H,11H2,1-5H3 BBFTWAOVJHOJQP-UHFFFAOYSA-N 236783 US9388149, 14 (Diastereoisomer 2)::US9580412, Example 14 C-X-C chemokine receptor type 2 Human 9999 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236783 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5556&target=C-X-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236783&enzyme=C-X-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 129012351 340130365 1 MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL 6LFO,6LFM,8XXX,8XXR,8XXH,8XX7,8XX6,8XX3,8XWV,8XWS,8XWN,8XWM,8XWF,8XWA,8XVU C-X-C chemokine receptor type 2 CXCR2_HUMAN P25025 Q8IUZ1 Q9P2T6 Q9P2T7 555280 COC(=O)[C@@H]1CCCN1C(=O)c1cccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1F |r,w:20.21| InChI=1S/C27H28FN3O6S/c1-14-10-11-18(37-14)21(19-9-5-13-38-19)30-23-22(24(32)25(23)33)29-16-7-3-6-15(20(16)28)26(34)31-12-4-8-17(31)27(35)36-2/h3,6-7,10-11,17,19,21,29-30H,4-5,8-9,12-13H2,1-2H3 OISJPBYRKOJZRI-UHFFFAOYSA-N 236784 US9388149, 15::US9580412, Example 15 C-X-C chemokine receptor type 1 Human 3808 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236784 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7515&target=C-X-C+chemokine+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236784&enzyme=C-X-C+chemokine+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 129012352 340130366 1 MSNITDPQMWDFDDLNFTGMPPADEDYSPCMLETETLNKYVVIIAYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGCWGLSMNLSLPFFLFRQAYHPNNSSPVCYEVLGNDTAKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQESCERRNNIGRALDATEILGFLHSCLNPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHRVTSYTSSSVNVSSNL 8IC0,2LNL C-X-C chemokine receptor type 1 CXCR1_HUMAN P25024 B2R6Q3 Q2YEF8 Q2YEG4 Q2YEG5 Q2YEG7 Q2YEG8 Q53R18 Q6IN95 Q8N6T6 Q9P2T8 Q9P2T9 Q9P2U0 Q9P2U1 Q9P2U2 555281 COC(=O)[C@@H]1CCCN1C(=O)c1cccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1F |r,w:20.21| InChI=1S/C27H28FN3O6S/c1-14-10-11-18(37-14)21(19-9-5-13-38-19)30-23-22(24(32)25(23)33)29-16-7-3-6-15(20(16)28)26(34)31-12-4-8-17(31)27(35)36-2/h3,6-7,10-11,17,19,21,29-30H,4-5,8-9,12-13H2,1-2H3 OISJPBYRKOJZRI-UHFFFAOYSA-N 236784 US9388149, 15::US9580412, Example 15 C-X-C chemokine receptor type 2 Human 294 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236784 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5556&target=C-X-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236784&enzyme=C-X-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 129012352 340130366 1 MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL 6LFO,6LFM,8XXX,8XXR,8XXH,8XX7,8XX6,8XX3,8XWV,8XWS,8XWN,8XWM,8XWF,8XWA,8XVU C-X-C chemokine receptor type 2 CXCR2_HUMAN P25025 Q8IUZ1 Q9P2T6 Q9P2T7 555282 Cc1ccc(o1)C(Nc1c(Nc2cccnc2O)c(=O)c1=O)C1CCCS1 |w:6.24| InChI=1S/C19H19N3O4S/c1-10-6-7-12(26-10)14(13-5-3-9-27-13)22-16-15(17(23)18(16)24)21-11-4-2-8-20-19(11)25/h2,4,6-8,13-14,21-22H,3,5,9H2,1H3,(H,20,25) XETXTFIIXKTWPQ-UHFFFAOYSA-N 236785 US9388149, 16::US9580412, Example 16 C-X-C chemokine receptor type 1 Human 652 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236785 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7515&target=C-X-C+chemokine+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236785&enzyme=C-X-C+chemokine+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 129012353 340130367 1 MSNITDPQMWDFDDLNFTGMPPADEDYSPCMLETETLNKYVVIIAYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGCWGLSMNLSLPFFLFRQAYHPNNSSPVCYEVLGNDTAKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQESCERRNNIGRALDATEILGFLHSCLNPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHRVTSYTSSSVNVSSNL 8IC0,2LNL C-X-C chemokine receptor type 1 CXCR1_HUMAN P25024 B2R6Q3 Q2YEF8 Q2YEG4 Q2YEG5 Q2YEG7 Q2YEG8 Q53R18 Q6IN95 Q8N6T6 Q9P2T8 Q9P2T9 Q9P2U0 Q9P2U1 Q9P2U2 555283 Cc1ccc(o1)C(Nc1c(Nc2cccnc2O)c(=O)c1=O)C1CCCS1 |w:6.24| InChI=1S/C19H19N3O4S/c1-10-6-7-12(26-10)14(13-5-3-9-27-13)22-16-15(17(23)18(16)24)21-11-4-2-8-20-19(11)25/h2,4,6-8,13-14,21-22H,3,5,9H2,1H3,(H,20,25) XETXTFIIXKTWPQ-UHFFFAOYSA-N 236785 US9388149, 16::US9580412, Example 16 C-X-C chemokine receptor type 2 Human 23.0 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236785 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5556&target=C-X-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236785&enzyme=C-X-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 129012353 340130367 1 MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL 6LFO,6LFM,8XXX,8XXR,8XXH,8XX7,8XX6,8XX3,8XWV,8XWS,8XWN,8XWM,8XWF,8XWA,8XVU C-X-C chemokine receptor type 2 CXCR2_HUMAN P25025 Q8IUZ1 Q9P2T6 Q9P2T7 555284 Cc1ccc(o1)C(Nc1c(Nc2cccn(C)c2=O)c(=O)c1=O)C1CCCS1 |w:6.25| InChI=1S/C20H21N3O4S/c1-11-7-8-13(27-11)15(14-6-4-10-28-14)22-17-16(18(24)19(17)25)21-12-5-3-9-23(2)20(12)26/h3,5,7-9,14-15,21-22H,4,6,10H2,1-2H3 LPLKAXWKZWWASO-UHFFFAOYSA-N 291188 3-{[(5-methylfuran-2-yl)-(tetrahydrothiophen-2-yl)methyl]amino}-4-(1-methyl-2-oxo-1,2-dihydropyridin-3-ylamino)cyclobut-3-ene-1,2-dione::US9580412, Example 17 C-X-C chemokine receptor type 1 Human 384 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291188 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7515&target=C-X-C+chemokine+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291188&enzyme=C-X-C+chemokine+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 137528696 381611493 1 MSNITDPQMWDFDDLNFTGMPPADEDYSPCMLETETLNKYVVIIAYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGCWGLSMNLSLPFFLFRQAYHPNNSSPVCYEVLGNDTAKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQESCERRNNIGRALDATEILGFLHSCLNPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHRVTSYTSSSVNVSSNL 8IC0,2LNL C-X-C chemokine receptor type 1 CXCR1_HUMAN P25024 B2R6Q3 Q2YEF8 Q2YEG4 Q2YEG5 Q2YEG7 Q2YEG8 Q53R18 Q6IN95 Q8N6T6 Q9P2T8 Q9P2T9 Q9P2U0 Q9P2U1 Q9P2U2 555285 Cc1ccc(o1)C(Nc1c(Nc2cccn(C)c2=O)c(=O)c1=O)C1CCCS1 |w:6.25| InChI=1S/C20H21N3O4S/c1-11-7-8-13(27-11)15(14-6-4-10-28-14)22-17-16(18(24)19(17)25)21-12-5-3-9-23(2)20(12)26/h3,5,7-9,14-15,21-22H,4,6,10H2,1-2H3 LPLKAXWKZWWASO-UHFFFAOYSA-N 291188 3-{[(5-methylfuran-2-yl)-(tetrahydrothiophen-2-yl)methyl]amino}-4-(1-methyl-2-oxo-1,2-dihydropyridin-3-ylamino)cyclobut-3-ene-1,2-dione::US9580412, Example 17 C-X-C chemokine receptor type 2 Human 44.0 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291188 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5556&target=C-X-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291188&enzyme=C-X-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 137528696 381611493 1 MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL 6LFO,6LFM,8XXX,8XXR,8XXH,8XX7,8XX6,8XX3,8XWV,8XWS,8XWN,8XWM,8XWF,8XWA,8XVU C-X-C chemokine receptor type 2 CXCR2_HUMAN P25025 Q8IUZ1 Q9P2T6 Q9P2T7 555286 CN(CC(F)(F)F)C(=O)c1cccc(Nc2c(N[C@H](C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O |r,w:19.23| InChI=1S/C24H24F3N3O5S/c1-12-8-9-15(35-12)17(16-7-4-10-36-16)29-19-18(21(32)22(19)33)28-14-6-3-5-13(20(14)31)23(34)30(2)11-24(25,26)27/h3,5-6,8-9,16-17,28-29,31H,4,7,10-11H2,1-2H3 KBLOFZHBIDLNIS-UHFFFAOYSA-N 236787 US9388149, 18::US9580412, Example 18 C-X-C chemokine receptor type 1 Human 36.0 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236787 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7515&target=C-X-C+chemokine+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236787&enzyme=C-X-C+chemokine+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 129012355 340130369 1 MSNITDPQMWDFDDLNFTGMPPADEDYSPCMLETETLNKYVVIIAYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGCWGLSMNLSLPFFLFRQAYHPNNSSPVCYEVLGNDTAKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQESCERRNNIGRALDATEILGFLHSCLNPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHRVTSYTSSSVNVSSNL 8IC0,2LNL C-X-C chemokine receptor type 1 CXCR1_HUMAN P25024 B2R6Q3 Q2YEF8 Q2YEG4 Q2YEG5 Q2YEG7 Q2YEG8 Q53R18 Q6IN95 Q8N6T6 Q9P2T8 Q9P2T9 Q9P2U0 Q9P2U1 Q9P2U2 555287 CN(CC(F)(F)F)C(=O)c1cccc(Nc2c(N[C@H](C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O |r,w:19.23| InChI=1S/C24H24F3N3O5S/c1-12-8-9-15(35-12)17(16-7-4-10-36-16)29-19-18(21(32)22(19)33)28-14-6-3-5-13(20(14)31)23(34)30(2)11-24(25,26)27/h3,5-6,8-9,16-17,28-29,31H,4,7,10-11H2,1-2H3 KBLOFZHBIDLNIS-UHFFFAOYSA-N 236787 US9388149, 18::US9580412, Example 18 C-X-C chemokine receptor type 2 Human 15.0 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236787 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5556&target=C-X-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236787&enzyme=C-X-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 129012355 340130369 1 MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL 6LFO,6LFM,8XXX,8XXR,8XXH,8XX7,8XX6,8XX3,8XWV,8XWS,8XWN,8XWM,8XWF,8XWA,8XVU C-X-C chemokine receptor type 2 CXCR2_HUMAN P25025 Q8IUZ1 Q9P2T6 Q9P2T7 555288 COC(=O)CN(C)C(=O)c1cccc(Nc2c(N[C@H](C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O |r,w:19.23| InChI=1S/C25H27N3O7S/c1-13-9-10-16(35-13)19(17-8-5-11-36-17)27-21-20(23(31)24(21)32)26-15-7-4-6-14(22(15)30)25(33)28(2)12-18(29)34-3/h4,6-7,9-10,17,19,26-27,30H,5,8,11-12H2,1-3H3 JBBKREGWJICILL-UHFFFAOYSA-N 236788 US9388149, 19::US9580412, Example 19 C-X-C chemokine receptor type 1 Human 42.0 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236788 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7515&target=C-X-C+chemokine+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236788&enzyme=C-X-C+chemokine+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 129012356 340130370 1 MSNITDPQMWDFDDLNFTGMPPADEDYSPCMLETETLNKYVVIIAYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGCWGLSMNLSLPFFLFRQAYHPNNSSPVCYEVLGNDTAKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQESCERRNNIGRALDATEILGFLHSCLNPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHRVTSYTSSSVNVSSNL 8IC0,2LNL C-X-C chemokine receptor type 1 CXCR1_HUMAN P25024 B2R6Q3 Q2YEF8 Q2YEG4 Q2YEG5 Q2YEG7 Q2YEG8 Q53R18 Q6IN95 Q8N6T6 Q9P2T8 Q9P2T9 Q9P2U0 Q9P2U1 Q9P2U2 555289 COC(=O)CN(C)C(=O)c1cccc(Nc2c(N[C@H](C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O |r,w:19.23| InChI=1S/C25H27N3O7S/c1-13-9-10-16(35-13)19(17-8-5-11-36-17)27-21-20(23(31)24(21)32)26-15-7-4-6-14(22(15)30)25(33)28(2)12-18(29)34-3/h4,6-7,9-10,17,19,26-27,30H,5,8,11-12H2,1-3H3 JBBKREGWJICILL-UHFFFAOYSA-N 236788 US9388149, 19::US9580412, Example 19 C-X-C chemokine receptor type 2 Human 20.0 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236788 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5556&target=C-X-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236788&enzyme=C-X-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 129012356 340130370 1 MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL 6LFO,6LFM,8XXX,8XXR,8XXH,8XX7,8XX6,8XX3,8XWV,8XWS,8XWN,8XWM,8XWF,8XWA,8XVU C-X-C chemokine receptor type 2 CXCR2_HUMAN P25025 Q8IUZ1 Q9P2T6 Q9P2T7 555290 COC(=O)[C@H]1CCCN1C(=O)c1cccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O |r,w:21.21| InChI=1S/C27H29N3O7S/c1-14-10-11-18(37-14)20(19-9-5-13-38-19)29-22-21(24(32)25(22)33)28-16-7-3-6-15(23(16)31)26(34)30-12-4-8-17(30)27(35)36-2/h3,6-7,10-11,17,19-20,28-29,31H,4-5,8-9,12-13H2,1-2H3 HDQNDRCZSVEGSG-UHFFFAOYSA-N 236789 US9388149, 20::US9580412, Example 20 C-X-C chemokine receptor type 1 Human 43.0 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236789 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7515&target=C-X-C+chemokine+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236789&enzyme=C-X-C+chemokine+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 129012357 340130371 1 MSNITDPQMWDFDDLNFTGMPPADEDYSPCMLETETLNKYVVIIAYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGCWGLSMNLSLPFFLFRQAYHPNNSSPVCYEVLGNDTAKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQESCERRNNIGRALDATEILGFLHSCLNPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHRVTSYTSSSVNVSSNL 8IC0,2LNL C-X-C chemokine receptor type 1 CXCR1_HUMAN P25024 B2R6Q3 Q2YEF8 Q2YEG4 Q2YEG5 Q2YEG7 Q2YEG8 Q53R18 Q6IN95 Q8N6T6 Q9P2T8 Q9P2T9 Q9P2U0 Q9P2U1 Q9P2U2 555291 COC(=O)[C@H]1CCCN1C(=O)c1cccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O |r,w:21.21| InChI=1S/C27H29N3O7S/c1-14-10-11-18(37-14)20(19-9-5-13-38-19)29-22-21(24(32)25(22)33)28-16-7-3-6-15(23(16)31)26(34)30-12-4-8-17(30)27(35)36-2/h3,6-7,10-11,17,19-20,28-29,31H,4-5,8-9,12-13H2,1-2H3 HDQNDRCZSVEGSG-UHFFFAOYSA-N 236789 US9388149, 20::US9580412, Example 20 C-X-C chemokine receptor type 2 Human 21.0 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236789 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5556&target=C-X-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236789&enzyme=C-X-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 129012357 340130371 1 MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL 6LFO,6LFM,8XXX,8XXR,8XXH,8XX7,8XX6,8XX3,8XWV,8XWS,8XWN,8XWM,8XWF,8XWA,8XVU C-X-C chemokine receptor type 2 CXCR2_HUMAN P25025 Q8IUZ1 Q9P2T6 Q9P2T7 555292 CN(C)C(=O)c1c(Cl)ccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O |w:15.15| InChI=1S/C23H24ClN3O5S/c1-11-6-9-14(32-11)17(15-5-4-10-33-15)26-19-18(21(29)22(19)30)25-13-8-7-12(24)16(20(13)28)23(31)27(2)3/h6-9,15,17,25-26,28H,4-5,10H2,1-3H3 BIVKRDOOTZFPRA-UHFFFAOYSA-N 291192 (−)-6-chloro-2-hydroxy-N,N-dimethyl-3-(2-{[((S)-5-methylfuran-2-yl)-(tetrahydrothiophen-2-yl)methyl]amino}-3,4-dioxocyclobut-1-enylamino)benzamide::US9580412, Example 21 C-X-C chemokine receptor type 1 Human 113 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291192 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7515&target=C-X-C+chemokine+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291192&enzyme=C-X-C+chemokine+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 129012358 381611497 1 MSNITDPQMWDFDDLNFTGMPPADEDYSPCMLETETLNKYVVIIAYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGCWGLSMNLSLPFFLFRQAYHPNNSSPVCYEVLGNDTAKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQESCERRNNIGRALDATEILGFLHSCLNPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHRVTSYTSSSVNVSSNL 8IC0,2LNL C-X-C chemokine receptor type 1 CXCR1_HUMAN P25024 B2R6Q3 Q2YEF8 Q2YEG4 Q2YEG5 Q2YEG7 Q2YEG8 Q53R18 Q6IN95 Q8N6T6 Q9P2T8 Q9P2T9 Q9P2U0 Q9P2U1 Q9P2U2 555293 CN(C)C(=O)c1c(Cl)ccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O |w:15.15| InChI=1S/C23H24ClN3O5S/c1-11-6-9-14(32-11)17(15-5-4-10-33-15)26-19-18(21(29)22(19)30)25-13-8-7-12(24)16(20(13)28)23(31)27(2)3/h6-9,15,17,25-26,28H,4-5,10H2,1-3H3 BIVKRDOOTZFPRA-UHFFFAOYSA-N 291192 (−)-6-chloro-2-hydroxy-N,N-dimethyl-3-(2-{[((S)-5-methylfuran-2-yl)-(tetrahydrothiophen-2-yl)methyl]amino}-3,4-dioxocyclobut-1-enylamino)benzamide::US9580412, Example 21 C-X-C chemokine receptor type 2 Human 69.0 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291192 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5556&target=C-X-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291192&enzyme=C-X-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 129012358 381611497 1 MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL 6LFO,6LFM,8XXX,8XXR,8XXH,8XX7,8XX6,8XX3,8XWV,8XWS,8XWN,8XWM,8XWF,8XWA,8XVU C-X-C chemokine receptor type 2 CXCR2_HUMAN P25025 Q8IUZ1 Q9P2T6 Q9P2T7 555294 CN1CCN(CC1)S(=O)(=O)c1c(Cl)ccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O |w:20.21| InChI=1S/C25H29ClN4O6S2/c1-14-5-8-17(36-14)19(18-4-3-13-37-18)28-21-20(23(32)24(21)33)27-16-7-6-15(26)25(22(16)31)38(34,35)30-11-9-29(2)10-12-30/h5-8,18-19,27-28,31H,3-4,9-13H2,1-2H3 SPLGZZDGUQTEHE-UHFFFAOYSA-N 236791 US9388149, 22::US9580412, Example 22 C-X-C chemokine receptor type 1 Human 30.0 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236791 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7515&target=C-X-C+chemokine+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236791&enzyme=C-X-C+chemokine+receptor+type+1&column=ki&startPg=0&Increment=50&submit=Search 129012359 340130373 1 MSNITDPQMWDFDDLNFTGMPPADEDYSPCMLETETLNKYVVIIAYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGCWGLSMNLSLPFFLFRQAYHPNNSSPVCYEVLGNDTAKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQESCERRNNIGRALDATEILGFLHSCLNPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHRVTSYTSSSVNVSSNL 8IC0,2LNL C-X-C chemokine receptor type 1 CXCR1_HUMAN P25024 B2R6Q3 Q2YEF8 Q2YEG4 Q2YEG5 Q2YEG7 Q2YEG8 Q53R18 Q6IN95 Q8N6T6 Q9P2T8 Q9P2T9 Q9P2U0 Q9P2U1 Q9P2U2 555295 CN1CCN(CC1)S(=O)(=O)c1c(Cl)ccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O |w:20.21| InChI=1S/C25H29ClN4O6S2/c1-14-5-8-17(36-14)19(18-4-3-13-37-18)28-21-20(23(32)24(21)33)27-16-7-6-15(26)25(22(16)31)38(34,35)30-11-9-29(2)10-12-30/h5-8,18-19,27-28,31H,3-4,9-13H2,1-2H3 SPLGZZDGUQTEHE-UHFFFAOYSA-N 236791 US9388149, 22::US9580412, Example 22 C-X-C chemokine receptor type 2 Human 17.0 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236791 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5556&target=C-X-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236791&enzyme=C-X-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 129012359 340130373 1 MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL 6LFO,6LFM,8XXX,8XXR,8XXH,8XX7,8XX6,8XX3,8XWV,8XWS,8XWN,8XWM,8XWF,8XWA,8XVU C-X-C chemokine receptor type 2 CXCR2_HUMAN P25025 Q8IUZ1 Q9P2T6 Q9P2T7 555296 CNC(=O)c1cccc(NC2C(NC(c3ccc(C)o3)C3(C)CCCO3)C(=O)C2=O)c1O InChI=1S/C23H27N3O6/c1-12-8-9-15(32-12)21(23(2)10-5-11-31-23)26-17-16(19(28)20(17)29)25-14-7-4-6-13(18(14)27)22(30)24-3/h4,6-9,16-17,21,25-27H,5,10-11H2,1-3H3,(H,24,30) AGJIIPQAPDGVQW-UHFFFAOYSA-N 291172 2-hydroxy-N,N-dimethyl-3-(2-{[(5-methylfuran-2-yl)-(2-methyltetrahydrofuran-2-yl)methyl]amino}-3,4-dioxocyclobut-1-enylamino)benzamide::US9580412, Example 1 C-C chemokine receptor type 4 Human 410 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291172 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7517&target=C-C+chemokine+receptor+type+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291172&enzyme=C-C+chemokine+receptor+type+4&column=ki&startPg=0&Increment=50&submit=Search 126624206 381611478 1 MNPTDIADTTLDESIYSNYYLYESIPKPCTKEGIKAFGELFLPPLYSLVFVFGLLGNSVVVLVLFKYKRLRSMTDVYLLNLAISDLLFVFSLPFWGYYAADQWVFGLGLCKMISWMYLVGFYSGIFFVMLMSIDRYLAIVHAVFSLRARTLTYGVITSLATWSVAVFASLPGFLFSTCYTERNHTYCKTKYSLNSTTWKVLSSLEINILGLVIPLGIMLFCYSMIIRTLQHCKNEKKNKAVKMIFAVVVLFLGFWTPYNIVLFLETLVELEVLQDCTFERYLDYAIQATETLAFVHCCLNPIIYFFLGEKFRKYILQLFKTCRGLFVLCQYCGLLQIYSADTPSSSYTQSTMDHDLHDAL C-C chemokine receptor type 4 CCR4_HUMAN P51679 Q9ULY6 Q9ULY7 555297 CNC(=O)c1cccc(NC2C(NC(c3ccc(C)o3)C3(C)CCCO3)C(=O)C2=O)c1O InChI=1S/C23H27N3O6/c1-12-8-9-15(32-12)21(23(2)10-5-11-31-23)26-17-16(19(28)20(17)29)25-14-7-4-6-13(18(14)27)22(30)24-3/h4,6-9,16-17,21,25-27H,5,10-11H2,1-3H3,(H,24,30) AGJIIPQAPDGVQW-UHFFFAOYSA-N 291172 2-hydroxy-N,N-dimethyl-3-(2-{[(5-methylfuran-2-yl)-(2-methyltetrahydrofuran-2-yl)methyl]amino}-3,4-dioxocyclobut-1-enylamino)benzamide::US9580412, Example 1 C-C chemokine receptor type 6 Human 2.00 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291172 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7518&target=C-C+chemokine+receptor+type+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291172&enzyme=C-C+chemokine+receptor+type+6&column=ki&startPg=0&Increment=50&submit=Search 126624206 381611478 1 MSGESMNFSDVFDSSEDYFVSVNTSYYSVDSEMLLCSLQEVRQFSRLFVPIAYSLICVFGLLGNILVVITFAFYKKARSMTDVYLLNMAIADILFVLTLPFWAVSHATGAWVFSNATCKLLKGIYAINFNCGMLLLTCISMDRYIAIVQATKSFRLRSRTLPRSKIICLVVWGLSVIISSSTFVFNQKYNTQGSDVCEPKYQTVSEPIRWKLLMLGLELLFGFFIPLMFMIFCYTFIVKTLVQAQNSKRHKAIRVIIAVVLVFLACQIPHNMVLLVTAANLGKMNRSCQSEKLIGYTKTVTEVLAFLHCCLNPVLYAFIGQKFRNYFLKILKDLWCVRRKYKSSGFSCAGRYSENISRQTSETADNDNASSFTM 6WWZ C-C chemokine receptor type 6 CCR6_HUMAN P51684 E1P5C6 P78553 Q92846 555298 CNC(=O)c1cccc(NC2C(NC(c3ccc(C)o3)C3(C)CCCO3)C(=O)C2=O)c1O InChI=1S/C23H27N3O6/c1-12-8-9-15(32-12)21(23(2)10-5-11-31-23)26-17-16(19(28)20(17)29)25-14-7-4-6-13(18(14)27)22(30)24-3/h4,6-9,16-17,21,25-27H,5,10-11H2,1-3H3,(H,24,30) AGJIIPQAPDGVQW-UHFFFAOYSA-N 291172 2-hydroxy-N,N-dimethyl-3-(2-{[(5-methylfuran-2-yl)-(2-methyltetrahydrofuran-2-yl)methyl]amino}-3,4-dioxocyclobut-1-enylamino)benzamide::US9580412, Example 1 C-X-C chemokine receptor type 3 Human 1.30 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291172 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=402&target=C-X-C+chemokine+receptor+type+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291172&enzyme=C-X-C+chemokine+receptor+type+3&column=ki&startPg=0&Increment=50&submit=Search 126624206 381611478 1 MVLEVSDHQVLNDAEVAALLENFSSSYDYGENESDSCCTSPPCPQDFSLNFDRAFLPALYSLLFLLGLLGNGAVAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHCQYNFPQVGRTALRVLQLVAGFLLPLLVMAYCYAHILAVLLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESRVDVAKSVTSGLGYMHCCLNPLLYAFVGVKFRERMWMLLLRLGCPNQRGLQRQPSSSRRDSSWSETSEASYSGL 8Y0N,8Y0H,8XYK,8XYI,8XXZ,8XXY,8K2X,8HNM,8HNL,8HNK C-X-C chemokine receptor type 3 CXCR3_HUMAN P49682 B2R982 O15185 Q7Z710 Q9P2T4 Q9P2T5 555299 CN(C)C(=O)c1cccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O InChI=1S/C23H25N3O5S/c1-12-9-10-15(31-12)17(16-8-5-11-32-16)25-19-18(21(28)22(19)29)24-14-7-4-6-13(20(14)27)23(30)26(2)3/h4,6-7,9-10,16-17,24-25,27H,5,8,11H2,1-3H3 KCVWGCOBGFLUEB-UHFFFAOYSA-N 236795 US9388149, 2 (Enantiomer 1 of diastereoisomer 2)::US9388149, 2 (Enantiomer 2 of diastereoisomer 2)::US9388149, 2 (Enantiomer 1 of diastereoisomer 1)::US9388149, 2 (Diastereoisomer 2)::US9388149, 2 (Diastereoisomer 1)::US9388149, 2 (Enantiomer 2 of diastereoisomer 1)::US9580412, Example 2 C-C chemokine receptor type 4 Human 52.0 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236795 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7517&target=C-C+chemokine+receptor+type+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236795&enzyme=C-C+chemokine+receptor+type+4&column=ki&startPg=0&Increment=50&submit=Search 129012361 340130375 1 MNPTDIADTTLDESIYSNYYLYESIPKPCTKEGIKAFGELFLPPLYSLVFVFGLLGNSVVVLVLFKYKRLRSMTDVYLLNLAISDLLFVFSLPFWGYYAADQWVFGLGLCKMISWMYLVGFYSGIFFVMLMSIDRYLAIVHAVFSLRARTLTYGVITSLATWSVAVFASLPGFLFSTCYTERNHTYCKTKYSLNSTTWKVLSSLEINILGLVIPLGIMLFCYSMIIRTLQHCKNEKKNKAVKMIFAVVVLFLGFWTPYNIVLFLETLVELEVLQDCTFERYLDYAIQATETLAFVHCCLNPIIYFFLGEKFRKYILQLFKTCRGLFVLCQYCGLLQIYSADTPSSSYTQSTMDHDLHDAL C-C chemokine receptor type 4 CCR4_HUMAN P51679 Q9ULY6 Q9ULY7 555300 CN(C)C(=O)c1cccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O InChI=1S/C23H25N3O5S/c1-12-9-10-15(31-12)17(16-8-5-11-32-16)25-19-18(21(28)22(19)29)24-14-7-4-6-13(20(14)27)23(30)26(2)3/h4,6-7,9-10,16-17,24-25,27H,5,8,11H2,1-3H3 KCVWGCOBGFLUEB-UHFFFAOYSA-N 236795 US9388149, 2 (Enantiomer 1 of diastereoisomer 2)::US9388149, 2 (Enantiomer 2 of diastereoisomer 2)::US9388149, 2 (Enantiomer 1 of diastereoisomer 1)::US9388149, 2 (Diastereoisomer 2)::US9388149, 2 (Diastereoisomer 1)::US9388149, 2 (Enantiomer 2 of diastereoisomer 1)::US9580412, Example 2 C-C chemokine receptor type 6 Human 8.00 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236795 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7518&target=C-C+chemokine+receptor+type+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236795&enzyme=C-C+chemokine+receptor+type+6&column=ki&startPg=0&Increment=50&submit=Search 129012361 340130375 1 MSGESMNFSDVFDSSEDYFVSVNTSYYSVDSEMLLCSLQEVRQFSRLFVPIAYSLICVFGLLGNILVVITFAFYKKARSMTDVYLLNMAIADILFVLTLPFWAVSHATGAWVFSNATCKLLKGIYAINFNCGMLLLTCISMDRYIAIVQATKSFRLRSRTLPRSKIICLVVWGLSVIISSSTFVFNQKYNTQGSDVCEPKYQTVSEPIRWKLLMLGLELLFGFFIPLMFMIFCYTFIVKTLVQAQNSKRHKAIRVIIAVVLVFLACQIPHNMVLLVTAANLGKMNRSCQSEKLIGYTKTVTEVLAFLHCCLNPVLYAFIGQKFRNYFLKILKDLWCVRRKYKSSGFSCAGRYSENISRQTSETADNDNASSFTM 6WWZ C-C chemokine receptor type 6 CCR6_HUMAN P51684 E1P5C6 P78553 Q92846 555301 CN(C)C(=O)c1cccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O InChI=1S/C23H25N3O5S/c1-12-9-10-15(31-12)17(16-8-5-11-32-16)25-19-18(21(28)22(19)29)24-14-7-4-6-13(20(14)27)23(30)26(2)3/h4,6-7,9-10,16-17,24-25,27H,5,8,11H2,1-3H3 KCVWGCOBGFLUEB-UHFFFAOYSA-N 236795 US9388149, 2 (Enantiomer 1 of diastereoisomer 2)::US9388149, 2 (Enantiomer 2 of diastereoisomer 2)::US9388149, 2 (Enantiomer 1 of diastereoisomer 1)::US9388149, 2 (Diastereoisomer 2)::US9388149, 2 (Diastereoisomer 1)::US9388149, 2 (Enantiomer 2 of diastereoisomer 1)::US9580412, Example 2 C-X-C chemokine receptor type 3 Human 1700 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236795 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=402&target=C-X-C+chemokine+receptor+type+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236795&enzyme=C-X-C+chemokine+receptor+type+3&column=ki&startPg=0&Increment=50&submit=Search 129012361 340130375 1 MVLEVSDHQVLNDAEVAALLENFSSSYDYGENESDSCCTSPPCPQDFSLNFDRAFLPALYSLLFLLGLLGNGAVAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHCQYNFPQVGRTALRVLQLVAGFLLPLLVMAYCYAHILAVLLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESRVDVAKSVTSGLGYMHCCLNPLLYAFVGVKFRERMWMLLLRLGCPNQRGLQRQPSSSRRDSSWSETSEASYSGL 8Y0N,8Y0H,8XYK,8XYI,8XXZ,8XXY,8K2X,8HNM,8HNL,8HNK C-X-C chemokine receptor type 3 CXCR3_HUMAN P49682 B2R982 O15185 Q7Z710 Q9P2T4 Q9P2T5 555302 CNC(=O)c1cccc(NC2C(NC(c3ccc(C)o3)C3(C)CCCO3)C(=O)C2=O)c1O InChI=1S/C23H27N3O6/c1-12-8-9-15(32-12)21(23(2)10-5-11-31-23)26-17-16(19(28)20(17)29)25-14-7-4-6-13(18(14)27)22(30)24-3/h4,6-9,16-17,21,25-27H,5,10-11H2,1-3H3,(H,24,30) AGJIIPQAPDGVQW-UHFFFAOYSA-N 291172 2-hydroxy-N,N-dimethyl-3-(2-{[(5-methylfuran-2-yl)-(2-methyltetrahydrofuran-2-yl)methyl]amino}-3,4-dioxocyclobut-1-enylamino)benzamide::US9580412, Example 1 C-C chemokine receptor type 6 Human 2.20 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291172 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7518&target=C-C+chemokine+receptor+type+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291172&enzyme=C-C+chemokine+receptor+type+6&column=ki&startPg=0&Increment=50&submit=Search 126624206 381611478 1 MSGESMNFSDVFDSSEDYFVSVNTSYYSVDSEMLLCSLQEVRQFSRLFVPIAYSLICVFGLLGNILVVITFAFYKKARSMTDVYLLNMAIADILFVLTLPFWAVSHATGAWVFSNATCKLLKGIYAINFNCGMLLLTCISMDRYIAIVQATKSFRLRSRTLPRSKIICLVVWGLSVIISSSTFVFNQKYNTQGSDVCEPKYQTVSEPIRWKLLMLGLELLFGFFIPLMFMIFCYTFIVKTLVQAQNSKRHKAIRVIIAVVLVFLACQIPHNMVLLVTAANLGKMNRSCQSEKLIGYTKTVTEVLAFLHCCLNPVLYAFIGQKFRNYFLKILKDLWCVRRKYKSSGFSCAGRYSENISRQTSETADNDNASSFTM 6WWZ C-C chemokine receptor type 6 CCR6_HUMAN P51684 E1P5C6 P78553 Q92846 555303 CNC(=O)c1cccc(NC2C(NC(c3ccc(C)o3)C3(C)CCCO3)C(=O)C2=O)c1O InChI=1S/C23H27N3O6/c1-12-8-9-15(32-12)21(23(2)10-5-11-31-23)26-17-16(19(28)20(17)29)25-14-7-4-6-13(18(14)27)22(30)24-3/h4,6-9,16-17,21,25-27H,5,10-11H2,1-3H3,(H,24,30) AGJIIPQAPDGVQW-UHFFFAOYSA-N 291172 2-hydroxy-N,N-dimethyl-3-(2-{[(5-methylfuran-2-yl)-(2-methyltetrahydrofuran-2-yl)methyl]amino}-3,4-dioxocyclobut-1-enylamino)benzamide::US9580412, Example 1 C-X-C chemokine receptor type 3 Human 55.0 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291172 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=402&target=C-X-C+chemokine+receptor+type+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291172&enzyme=C-X-C+chemokine+receptor+type+3&column=ki&startPg=0&Increment=50&submit=Search 126624206 381611478 1 MVLEVSDHQVLNDAEVAALLENFSSSYDYGENESDSCCTSPPCPQDFSLNFDRAFLPALYSLLFLLGLLGNGAVAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHCQYNFPQVGRTALRVLQLVAGFLLPLLVMAYCYAHILAVLLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESRVDVAKSVTSGLGYMHCCLNPLLYAFVGVKFRERMWMLLLRLGCPNQRGLQRQPSSSRRDSSWSETSEASYSGL 8Y0N,8Y0H,8XYK,8XYI,8XXZ,8XXY,8K2X,8HNM,8HNL,8HNK C-X-C chemokine receptor type 3 CXCR3_HUMAN P49682 B2R982 O15185 Q7Z710 Q9P2T4 Q9P2T5 555304 CN(C)C(=O)c1cccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O InChI=1S/C23H25N3O5S/c1-12-9-10-15(31-12)17(16-8-5-11-32-16)25-19-18(21(28)22(19)29)24-14-7-4-6-13(20(14)27)23(30)26(2)3/h4,6-7,9-10,16-17,24-25,27H,5,8,11H2,1-3H3 KCVWGCOBGFLUEB-UHFFFAOYSA-N 236795 US9388149, 2 (Enantiomer 1 of diastereoisomer 2)::US9388149, 2 (Enantiomer 2 of diastereoisomer 2)::US9388149, 2 (Enantiomer 1 of diastereoisomer 1)::US9388149, 2 (Diastereoisomer 2)::US9388149, 2 (Diastereoisomer 1)::US9388149, 2 (Enantiomer 2 of diastereoisomer 1)::US9580412, Example 2 C-C chemokine receptor type 4 Human 250 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236795 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7517&target=C-C+chemokine+receptor+type+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236795&enzyme=C-C+chemokine+receptor+type+4&column=ki&startPg=0&Increment=50&submit=Search 129012361 340130375 1 MNPTDIADTTLDESIYSNYYLYESIPKPCTKEGIKAFGELFLPPLYSLVFVFGLLGNSVVVLVLFKYKRLRSMTDVYLLNLAISDLLFVFSLPFWGYYAADQWVFGLGLCKMISWMYLVGFYSGIFFVMLMSIDRYLAIVHAVFSLRARTLTYGVITSLATWSVAVFASLPGFLFSTCYTERNHTYCKTKYSLNSTTWKVLSSLEINILGLVIPLGIMLFCYSMIIRTLQHCKNEKKNKAVKMIFAVVVLFLGFWTPYNIVLFLETLVELEVLQDCTFERYLDYAIQATETLAFVHCCLNPIIYFFLGEKFRKYILQLFKTCRGLFVLCQYCGLLQIYSADTPSSSYTQSTMDHDLHDAL C-C chemokine receptor type 4 CCR4_HUMAN P51679 Q9ULY6 Q9ULY7 555305 CN(C)C(=O)c1cccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O InChI=1S/C23H25N3O5S/c1-12-9-10-15(31-12)17(16-8-5-11-32-16)25-19-18(21(28)22(19)29)24-14-7-4-6-13(20(14)27)23(30)26(2)3/h4,6-7,9-10,16-17,24-25,27H,5,8,11H2,1-3H3 KCVWGCOBGFLUEB-UHFFFAOYSA-N 236795 US9388149, 2 (Enantiomer 1 of diastereoisomer 2)::US9388149, 2 (Enantiomer 2 of diastereoisomer 2)::US9388149, 2 (Enantiomer 1 of diastereoisomer 1)::US9388149, 2 (Diastereoisomer 2)::US9388149, 2 (Diastereoisomer 1)::US9388149, 2 (Enantiomer 2 of diastereoisomer 1)::US9580412, Example 2 C-C chemokine receptor type 6 Human 6.00 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236795 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7518&target=C-C+chemokine+receptor+type+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236795&enzyme=C-C+chemokine+receptor+type+6&column=ki&startPg=0&Increment=50&submit=Search 129012361 340130375 1 MSGESMNFSDVFDSSEDYFVSVNTSYYSVDSEMLLCSLQEVRQFSRLFVPIAYSLICVFGLLGNILVVITFAFYKKARSMTDVYLLNMAIADILFVLTLPFWAVSHATGAWVFSNATCKLLKGIYAINFNCGMLLLTCISMDRYIAIVQATKSFRLRSRTLPRSKIICLVVWGLSVIISSSTFVFNQKYNTQGSDVCEPKYQTVSEPIRWKLLMLGLELLFGFFIPLMFMIFCYTFIVKTLVQAQNSKRHKAIRVIIAVVLVFLACQIPHNMVLLVTAANLGKMNRSCQSEKLIGYTKTVTEVLAFLHCCLNPVLYAFIGQKFRNYFLKILKDLWCVRRKYKSSGFSCAGRYSENISRQTSETADNDNASSFTM 6WWZ C-C chemokine receptor type 6 CCR6_HUMAN P51684 E1P5C6 P78553 Q92846 555306 CN(C)C(=O)c1cccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O InChI=1S/C23H25N3O5S/c1-12-9-10-15(31-12)17(16-8-5-11-32-16)25-19-18(21(28)22(19)29)24-14-7-4-6-13(20(14)27)23(30)26(2)3/h4,6-7,9-10,16-17,24-25,27H,5,8,11H2,1-3H3 KCVWGCOBGFLUEB-UHFFFAOYSA-N 236795 US9388149, 2 (Enantiomer 1 of diastereoisomer 2)::US9388149, 2 (Enantiomer 2 of diastereoisomer 2)::US9388149, 2 (Enantiomer 1 of diastereoisomer 1)::US9388149, 2 (Diastereoisomer 2)::US9388149, 2 (Diastereoisomer 1)::US9388149, 2 (Enantiomer 2 of diastereoisomer 1)::US9580412, Example 2 C-X-C chemokine receptor type 3 Human 216 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236795 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=402&target=C-X-C+chemokine+receptor+type+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236795&enzyme=C-X-C+chemokine+receptor+type+3&column=ki&startPg=0&Increment=50&submit=Search 129012361 340130375 1 MVLEVSDHQVLNDAEVAALLENFSSSYDYGENESDSCCTSPPCPQDFSLNFDRAFLPALYSLLFLLGLLGNGAVAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHCQYNFPQVGRTALRVLQLVAGFLLPLLVMAYCYAHILAVLLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESRVDVAKSVTSGLGYMHCCLNPLLYAFVGVKFRERMWMLLLRLGCPNQRGLQRQPSSSRRDSSWSETSEASYSGL 8Y0N,8Y0H,8XYK,8XYI,8XXZ,8XXY,8K2X,8HNM,8HNL,8HNK C-X-C chemokine receptor type 3 CXCR3_HUMAN P49682 B2R982 O15185 Q7Z710 Q9P2T4 Q9P2T5 555307 COC(=O)[C@H]1CCCN1C(=O)c1cccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O |r| InChI=1S/C27H29N3O7S/c1-14-10-11-18(37-14)20(19-9-5-13-38-19)29-22-21(24(32)25(22)33)28-16-7-3-6-15(23(16)31)26(34)30-12-4-8-17(30)27(35)36-2/h3,6-7,10-11,17,19-20,28-29,31H,4-5,8-9,12-13H2,1-2H3 HDQNDRCZSVEGSG-UHFFFAOYSA-N 291177 US9580412, Example 6::methyl (R)-1-[2-hydroxy-3-(2-{[(5-methylfuran-2-yl)-(tetrahydrothiophen-2-yl)methyl]amino}-3,4-dioxocyclobut-1-enylamino)benzoyl]pyrrolidine-2-carboxylate::US9580412, Example 7 C-C chemokine receptor type 6 Human 9.70 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291177 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7518&target=C-C+chemokine+receptor+type+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291177&enzyme=C-C+chemokine+receptor+type+6&column=ki&startPg=0&Increment=50&submit=Search 129012357 381611483 1 MSGESMNFSDVFDSSEDYFVSVNTSYYSVDSEMLLCSLQEVRQFSRLFVPIAYSLICVFGLLGNILVVITFAFYKKARSMTDVYLLNMAIADILFVLTLPFWAVSHATGAWVFSNATCKLLKGIYAINFNCGMLLLTCISMDRYIAIVQATKSFRLRSRTLPRSKIICLVVWGLSVIISSSTFVFNQKYNTQGSDVCEPKYQTVSEPIRWKLLMLGLELLFGFFIPLMFMIFCYTFIVKTLVQAQNSKRHKAIRVIIAVVLVFLACQIPHNMVLLVTAANLGKMNRSCQSEKLIGYTKTVTEVLAFLHCCLNPVLYAFIGQKFRNYFLKILKDLWCVRRKYKSSGFSCAGRYSENISRQTSETADNDNASSFTM 6WWZ C-C chemokine receptor type 6 CCR6_HUMAN P51684 E1P5C6 P78553 Q92846 555308 COC(=O)[C@H]1CCCN1C(=O)c1cccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O |r| InChI=1S/C27H29N3O7S/c1-14-10-11-18(37-14)20(19-9-5-13-38-19)29-22-21(24(32)25(22)33)28-16-7-3-6-15(23(16)31)26(34)30-12-4-8-17(30)27(35)36-2/h3,6-7,10-11,17,19-20,28-29,31H,4-5,8-9,12-13H2,1-2H3 HDQNDRCZSVEGSG-UHFFFAOYSA-N 291177 US9580412, Example 6::methyl (R)-1-[2-hydroxy-3-(2-{[(5-methylfuran-2-yl)-(tetrahydrothiophen-2-yl)methyl]amino}-3,4-dioxocyclobut-1-enylamino)benzoyl]pyrrolidine-2-carboxylate::US9580412, Example 7 C-X-C chemokine receptor type 3 Human 140 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291177 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=402&target=C-X-C+chemokine+receptor+type+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291177&enzyme=C-X-C+chemokine+receptor+type+3&column=ki&startPg=0&Increment=50&submit=Search 129012357 381611483 1 MVLEVSDHQVLNDAEVAALLENFSSSYDYGENESDSCCTSPPCPQDFSLNFDRAFLPALYSLLFLLGLLGNGAVAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHCQYNFPQVGRTALRVLQLVAGFLLPLLVMAYCYAHILAVLLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESRVDVAKSVTSGLGYMHCCLNPLLYAFVGVKFRERMWMLLLRLGCPNQRGLQRQPSSSRRDSSWSETSEASYSGL 8Y0N,8Y0H,8XYK,8XYI,8XXZ,8XXY,8K2X,8HNM,8HNL,8HNK C-X-C chemokine receptor type 3 CXCR3_HUMAN P49682 B2R982 O15185 Q7Z710 Q9P2T4 Q9P2T5 555309 CN(C)S(=O)(=O)c1cccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1C InChI=1S/C23H27N3O5S2/c1-13-10-11-16(31-13)19(17-8-6-12-32-17)25-21-20(22(27)23(21)28)24-15-7-5-9-18(14(15)2)33(29,30)26(3)4/h5,7,9-11,17,19,24-25H,6,8,12H2,1-4H3 DGPHJNJINCRCKW-UHFFFAOYSA-N 291181 6-chloro-2-hydroxy-N,N-dimethyl-3-(2-{[(5-methylfuran-2-yl)-(tetrahydrothiophen-2-yl)methyl]amino}-3,4-dioxocyclobut-1-enylamino)benzenesulfonamide::US9580412, Example 10 C-C chemokine receptor type 4 Human 39.0 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291181 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7517&target=C-C+chemokine+receptor+type+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291181&enzyme=C-C+chemokine+receptor+type+4&column=ki&startPg=0&Increment=50&submit=Search 137528695 381611486 1 MNPTDIADTTLDESIYSNYYLYESIPKPCTKEGIKAFGELFLPPLYSLVFVFGLLGNSVVVLVLFKYKRLRSMTDVYLLNLAISDLLFVFSLPFWGYYAADQWVFGLGLCKMISWMYLVGFYSGIFFVMLMSIDRYLAIVHAVFSLRARTLTYGVITSLATWSVAVFASLPGFLFSTCYTERNHTYCKTKYSLNSTTWKVLSSLEINILGLVIPLGIMLFCYSMIIRTLQHCKNEKKNKAVKMIFAVVVLFLGFWTPYNIVLFLETLVELEVLQDCTFERYLDYAIQATETLAFVHCCLNPIIYFFLGEKFRKYILQLFKTCRGLFVLCQYCGLLQIYSADTPSSSYTQSTMDHDLHDAL C-C chemokine receptor type 4 CCR4_HUMAN P51679 Q9ULY6 Q9ULY7 555310 CN(C)S(=O)(=O)c1cccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1C InChI=1S/C23H27N3O5S2/c1-13-10-11-16(31-13)19(17-8-6-12-32-17)25-21-20(22(27)23(21)28)24-15-7-5-9-18(14(15)2)33(29,30)26(3)4/h5,7,9-11,17,19,24-25H,6,8,12H2,1-4H3 DGPHJNJINCRCKW-UHFFFAOYSA-N 291181 6-chloro-2-hydroxy-N,N-dimethyl-3-(2-{[(5-methylfuran-2-yl)-(tetrahydrothiophen-2-yl)methyl]amino}-3,4-dioxocyclobut-1-enylamino)benzenesulfonamide::US9580412, Example 10 C-C chemokine receptor type 6 Human 1.60 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291181 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7518&target=C-C+chemokine+receptor+type+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291181&enzyme=C-C+chemokine+receptor+type+6&column=ki&startPg=0&Increment=50&submit=Search 137528695 381611486 1 MSGESMNFSDVFDSSEDYFVSVNTSYYSVDSEMLLCSLQEVRQFSRLFVPIAYSLICVFGLLGNILVVITFAFYKKARSMTDVYLLNMAIADILFVLTLPFWAVSHATGAWVFSNATCKLLKGIYAINFNCGMLLLTCISMDRYIAIVQATKSFRLRSRTLPRSKIICLVVWGLSVIISSSTFVFNQKYNTQGSDVCEPKYQTVSEPIRWKLLMLGLELLFGFFIPLMFMIFCYTFIVKTLVQAQNSKRHKAIRVIIAVVLVFLACQIPHNMVLLVTAANLGKMNRSCQSEKLIGYTKTVTEVLAFLHCCLNPVLYAFIGQKFRNYFLKILKDLWCVRRKYKSSGFSCAGRYSENISRQTSETADNDNASSFTM 6WWZ C-C chemokine receptor type 6 CCR6_HUMAN P51684 E1P5C6 P78553 Q92846 555311 CN(C)S(=O)(=O)c1cccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1C InChI=1S/C23H27N3O5S2/c1-13-10-11-16(31-13)19(17-8-6-12-32-17)25-21-20(22(27)23(21)28)24-15-7-5-9-18(14(15)2)33(29,30)26(3)4/h5,7,9-11,17,19,24-25H,6,8,12H2,1-4H3 DGPHJNJINCRCKW-UHFFFAOYSA-N 291181 6-chloro-2-hydroxy-N,N-dimethyl-3-(2-{[(5-methylfuran-2-yl)-(tetrahydrothiophen-2-yl)methyl]amino}-3,4-dioxocyclobut-1-enylamino)benzenesulfonamide::US9580412, Example 10 C-X-C chemokine receptor type 3 Human 93.0 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=291181 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=402&target=C-X-C+chemokine+receptor+type+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=291181&enzyme=C-X-C+chemokine+receptor+type+3&column=ki&startPg=0&Increment=50&submit=Search 137528695 381611486 1 MVLEVSDHQVLNDAEVAALLENFSSSYDYGENESDSCCTSPPCPQDFSLNFDRAFLPALYSLLFLLGLLGNGAVAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHCQYNFPQVGRTALRVLQLVAGFLLPLLVMAYCYAHILAVLLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESRVDVAKSVTSGLGYMHCCLNPLLYAFVGVKFRERMWMLLLRLGCPNQRGLQRQPSSSRRDSSWSETSEASYSGL 8Y0N,8Y0H,8XYK,8XYI,8XXZ,8XXY,8K2X,8HNM,8HNL,8HNK C-X-C chemokine receptor type 3 CXCR3_HUMAN P49682 B2R982 O15185 Q7Z710 Q9P2T4 Q9P2T5 555312 CN(CC(F)(F)F)C(=O)c1cccc(Nc2c(N[C@H](C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O |r,w:19.23| InChI=1S/C24H24F3N3O5S/c1-12-8-9-15(35-12)17(16-7-4-10-36-16)29-19-18(21(32)22(19)33)28-14-6-3-5-13(20(14)31)23(34)30(2)11-24(25,26)27/h3,5-6,8-9,16-17,28-29,31H,4,7,10-11H2,1-2H3 KBLOFZHBIDLNIS-UHFFFAOYSA-N 236787 US9388149, 18::US9580412, Example 18 C-C chemokine receptor type 4 Human 97.0 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236787 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7517&target=C-C+chemokine+receptor+type+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236787&enzyme=C-C+chemokine+receptor+type+4&column=ki&startPg=0&Increment=50&submit=Search 129012355 340130369 1 MNPTDIADTTLDESIYSNYYLYESIPKPCTKEGIKAFGELFLPPLYSLVFVFGLLGNSVVVLVLFKYKRLRSMTDVYLLNLAISDLLFVFSLPFWGYYAADQWVFGLGLCKMISWMYLVGFYSGIFFVMLMSIDRYLAIVHAVFSLRARTLTYGVITSLATWSVAVFASLPGFLFSTCYTERNHTYCKTKYSLNSTTWKVLSSLEINILGLVIPLGIMLFCYSMIIRTLQHCKNEKKNKAVKMIFAVVVLFLGFWTPYNIVLFLETLVELEVLQDCTFERYLDYAIQATETLAFVHCCLNPIIYFFLGEKFRKYILQLFKTCRGLFVLCQYCGLLQIYSADTPSSSYTQSTMDHDLHDAL C-C chemokine receptor type 4 CCR4_HUMAN P51679 Q9ULY6 Q9ULY7 555313 CN(CC(F)(F)F)C(=O)c1cccc(Nc2c(N[C@H](C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O |r,w:19.23| InChI=1S/C24H24F3N3O5S/c1-12-8-9-15(35-12)17(16-7-4-10-36-16)29-19-18(21(32)22(19)33)28-14-6-3-5-13(20(14)31)23(34)30(2)11-24(25,26)27/h3,5-6,8-9,16-17,28-29,31H,4,7,10-11H2,1-2H3 KBLOFZHBIDLNIS-UHFFFAOYSA-N 236787 US9388149, 18::US9580412, Example 18 C-C chemokine receptor type 6 Human 60.0 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236787 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7518&target=C-C+chemokine+receptor+type+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236787&enzyme=C-C+chemokine+receptor+type+6&column=ki&startPg=0&Increment=50&submit=Search 129012355 340130369 1 MSGESMNFSDVFDSSEDYFVSVNTSYYSVDSEMLLCSLQEVRQFSRLFVPIAYSLICVFGLLGNILVVITFAFYKKARSMTDVYLLNMAIADILFVLTLPFWAVSHATGAWVFSNATCKLLKGIYAINFNCGMLLLTCISMDRYIAIVQATKSFRLRSRTLPRSKIICLVVWGLSVIISSSTFVFNQKYNTQGSDVCEPKYQTVSEPIRWKLLMLGLELLFGFFIPLMFMIFCYTFIVKTLVQAQNSKRHKAIRVIIAVVLVFLACQIPHNMVLLVTAANLGKMNRSCQSEKLIGYTKTVTEVLAFLHCCLNPVLYAFIGQKFRNYFLKILKDLWCVRRKYKSSGFSCAGRYSENISRQTSETADNDNASSFTM 6WWZ C-C chemokine receptor type 6 CCR6_HUMAN P51684 E1P5C6 P78553 Q92846 555314 CN(CC(F)(F)F)C(=O)c1cccc(Nc2c(N[C@H](C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O |r,w:19.23| InChI=1S/C24H24F3N3O5S/c1-12-8-9-15(35-12)17(16-7-4-10-36-16)29-19-18(21(32)22(19)33)28-14-6-3-5-13(20(14)31)23(34)30(2)11-24(25,26)27/h3,5-6,8-9,16-17,28-29,31H,4,7,10-11H2,1-2H3 KBLOFZHBIDLNIS-UHFFFAOYSA-N 236787 US9388149, 18::US9580412, Example 18 C-X-C chemokine receptor type 3 Human 450 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236787 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=402&target=C-X-C+chemokine+receptor+type+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236787&enzyme=C-X-C+chemokine+receptor+type+3&column=ki&startPg=0&Increment=50&submit=Search 129012355 340130369 1 MVLEVSDHQVLNDAEVAALLENFSSSYDYGENESDSCCTSPPCPQDFSLNFDRAFLPALYSLLFLLGLLGNGAVAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHCQYNFPQVGRTALRVLQLVAGFLLPLLVMAYCYAHILAVLLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESRVDVAKSVTSGLGYMHCCLNPLLYAFVGVKFRERMWMLLLRLGCPNQRGLQRQPSSSRRDSSWSETSEASYSGL 8Y0N,8Y0H,8XYK,8XYI,8XXZ,8XXY,8K2X,8HNM,8HNL,8HNK C-X-C chemokine receptor type 3 CXCR3_HUMAN P49682 B2R982 O15185 Q7Z710 Q9P2T4 Q9P2T5 555315 COC(=O)CN(C)C(=O)c1cccc(Nc2c(N[C@H](C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O |r,w:19.23| InChI=1S/C25H27N3O7S/c1-13-9-10-16(35-13)19(17-8-5-11-36-17)27-21-20(23(31)24(21)32)26-15-7-4-6-14(22(15)30)25(33)28(2)12-18(29)34-3/h4,6-7,9-10,17,19,26-27,30H,5,8,11-12H2,1-3H3 JBBKREGWJICILL-UHFFFAOYSA-N 236788 US9388149, 19::US9580412, Example 19 C-C chemokine receptor type 4 Human 8.10 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236788 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7517&target=C-C+chemokine+receptor+type+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236788&enzyme=C-C+chemokine+receptor+type+4&column=ki&startPg=0&Increment=50&submit=Search 129012356 340130370 1 MNPTDIADTTLDESIYSNYYLYESIPKPCTKEGIKAFGELFLPPLYSLVFVFGLLGNSVVVLVLFKYKRLRSMTDVYLLNLAISDLLFVFSLPFWGYYAADQWVFGLGLCKMISWMYLVGFYSGIFFVMLMSIDRYLAIVHAVFSLRARTLTYGVITSLATWSVAVFASLPGFLFSTCYTERNHTYCKTKYSLNSTTWKVLSSLEINILGLVIPLGIMLFCYSMIIRTLQHCKNEKKNKAVKMIFAVVVLFLGFWTPYNIVLFLETLVELEVLQDCTFERYLDYAIQATETLAFVHCCLNPIIYFFLGEKFRKYILQLFKTCRGLFVLCQYCGLLQIYSADTPSSSYTQSTMDHDLHDAL C-C chemokine receptor type 4 CCR4_HUMAN P51679 Q9ULY6 Q9ULY7 555316 COC(=O)CN(C)C(=O)c1cccc(Nc2c(N[C@H](C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O |r,w:19.23| InChI=1S/C25H27N3O7S/c1-13-9-10-16(35-13)19(17-8-5-11-36-17)27-21-20(23(31)24(21)32)26-15-7-4-6-14(22(15)30)25(33)28(2)12-18(29)34-3/h4,6-7,9-10,17,19,26-27,30H,5,8,11-12H2,1-3H3 JBBKREGWJICILL-UHFFFAOYSA-N 236788 US9388149, 19::US9580412, Example 19 C-C chemokine receptor type 6 Human 11.0 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236788 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7518&target=C-C+chemokine+receptor+type+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236788&enzyme=C-C+chemokine+receptor+type+6&column=ki&startPg=0&Increment=50&submit=Search 129012356 340130370 1 MSGESMNFSDVFDSSEDYFVSVNTSYYSVDSEMLLCSLQEVRQFSRLFVPIAYSLICVFGLLGNILVVITFAFYKKARSMTDVYLLNMAIADILFVLTLPFWAVSHATGAWVFSNATCKLLKGIYAINFNCGMLLLTCISMDRYIAIVQATKSFRLRSRTLPRSKIICLVVWGLSVIISSSTFVFNQKYNTQGSDVCEPKYQTVSEPIRWKLLMLGLELLFGFFIPLMFMIFCYTFIVKTLVQAQNSKRHKAIRVIIAVVLVFLACQIPHNMVLLVTAANLGKMNRSCQSEKLIGYTKTVTEVLAFLHCCLNPVLYAFIGQKFRNYFLKILKDLWCVRRKYKSSGFSCAGRYSENISRQTSETADNDNASSFTM 6WWZ C-C chemokine receptor type 6 CCR6_HUMAN P51684 E1P5C6 P78553 Q92846 555317 COC(=O)CN(C)C(=O)c1cccc(Nc2c(N[C@H](C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O |r,w:19.23| InChI=1S/C25H27N3O7S/c1-13-9-10-16(35-13)19(17-8-5-11-36-17)27-21-20(23(31)24(21)32)26-15-7-4-6-14(22(15)30)25(33)28(2)12-18(29)34-3/h4,6-7,9-10,17,19,26-27,30H,5,8,11-12H2,1-3H3 JBBKREGWJICILL-UHFFFAOYSA-N 236788 US9388149, 19::US9580412, Example 19 C-X-C chemokine receptor type 3 Human 510 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236788 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=402&target=C-X-C+chemokine+receptor+type+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236788&enzyme=C-X-C+chemokine+receptor+type+3&column=ki&startPg=0&Increment=50&submit=Search 129012356 340130370 1 MVLEVSDHQVLNDAEVAALLENFSSSYDYGENESDSCCTSPPCPQDFSLNFDRAFLPALYSLLFLLGLLGNGAVAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHCQYNFPQVGRTALRVLQLVAGFLLPLLVMAYCYAHILAVLLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESRVDVAKSVTSGLGYMHCCLNPLLYAFVGVKFRERMWMLLLRLGCPNQRGLQRQPSSSRRDSSWSETSEASYSGL 8Y0N,8Y0H,8XYK,8XYI,8XXZ,8XXY,8K2X,8HNM,8HNL,8HNK C-X-C chemokine receptor type 3 CXCR3_HUMAN P49682 B2R982 O15185 Q7Z710 Q9P2T4 Q9P2T5 555318 COC(=O)[C@H]1CCCN1C(=O)c1cccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O |r,w:21.21| InChI=1S/C27H29N3O7S/c1-14-10-11-18(37-14)20(19-9-5-13-38-19)29-22-21(24(32)25(22)33)28-16-7-3-6-15(23(16)31)26(34)30-12-4-8-17(30)27(35)36-2/h3,6-7,10-11,17,19-20,28-29,31H,4-5,8-9,12-13H2,1-2H3 HDQNDRCZSVEGSG-UHFFFAOYSA-N 236789 US9388149, 20::US9580412, Example 20 C-C chemokine receptor type 4 Human 7.20 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236789 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7517&target=C-C+chemokine+receptor+type+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236789&enzyme=C-C+chemokine+receptor+type+4&column=ki&startPg=0&Increment=50&submit=Search 129012357 340130371 1 MNPTDIADTTLDESIYSNYYLYESIPKPCTKEGIKAFGELFLPPLYSLVFVFGLLGNSVVVLVLFKYKRLRSMTDVYLLNLAISDLLFVFSLPFWGYYAADQWVFGLGLCKMISWMYLVGFYSGIFFVMLMSIDRYLAIVHAVFSLRARTLTYGVITSLATWSVAVFASLPGFLFSTCYTERNHTYCKTKYSLNSTTWKVLSSLEINILGLVIPLGIMLFCYSMIIRTLQHCKNEKKNKAVKMIFAVVVLFLGFWTPYNIVLFLETLVELEVLQDCTFERYLDYAIQATETLAFVHCCLNPIIYFFLGEKFRKYILQLFKTCRGLFVLCQYCGLLQIYSADTPSSSYTQSTMDHDLHDAL C-C chemokine receptor type 4 CCR4_HUMAN P51679 Q9ULY6 Q9ULY7 555319 COC(=O)[C@H]1CCCN1C(=O)c1cccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O |r,w:21.21| InChI=1S/C27H29N3O7S/c1-14-10-11-18(37-14)20(19-9-5-13-38-19)29-22-21(24(32)25(22)33)28-16-7-3-6-15(23(16)31)26(34)30-12-4-8-17(30)27(35)36-2/h3,6-7,10-11,17,19-20,28-29,31H,4-5,8-9,12-13H2,1-2H3 HDQNDRCZSVEGSG-UHFFFAOYSA-N 236789 US9388149, 20::US9580412, Example 20 C-C chemokine receptor type 6 Human 8.80 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236789 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7518&target=C-C+chemokine+receptor+type+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236789&enzyme=C-C+chemokine+receptor+type+6&column=ki&startPg=0&Increment=50&submit=Search 129012357 340130371 1 MSGESMNFSDVFDSSEDYFVSVNTSYYSVDSEMLLCSLQEVRQFSRLFVPIAYSLICVFGLLGNILVVITFAFYKKARSMTDVYLLNMAIADILFVLTLPFWAVSHATGAWVFSNATCKLLKGIYAINFNCGMLLLTCISMDRYIAIVQATKSFRLRSRTLPRSKIICLVVWGLSVIISSSTFVFNQKYNTQGSDVCEPKYQTVSEPIRWKLLMLGLELLFGFFIPLMFMIFCYTFIVKTLVQAQNSKRHKAIRVIIAVVLVFLACQIPHNMVLLVTAANLGKMNRSCQSEKLIGYTKTVTEVLAFLHCCLNPVLYAFIGQKFRNYFLKILKDLWCVRRKYKSSGFSCAGRYSENISRQTSETADNDNASSFTM 6WWZ C-C chemokine receptor type 6 CCR6_HUMAN P51684 E1P5C6 P78553 Q92846 555320 COC(=O)[C@H]1CCCN1C(=O)c1cccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O |r,w:21.21| InChI=1S/C27H29N3O7S/c1-14-10-11-18(37-14)20(19-9-5-13-38-19)29-22-21(24(32)25(22)33)28-16-7-3-6-15(23(16)31)26(34)30-12-4-8-17(30)27(35)36-2/h3,6-7,10-11,17,19-20,28-29,31H,4-5,8-9,12-13H2,1-2H3 HDQNDRCZSVEGSG-UHFFFAOYSA-N 236789 US9388149, 20::US9580412, Example 20 C-X-C chemokine receptor type 3 Human 180 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236789 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=402&target=C-X-C+chemokine+receptor+type+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236789&enzyme=C-X-C+chemokine+receptor+type+3&column=ki&startPg=0&Increment=50&submit=Search 129012357 340130371 1 MVLEVSDHQVLNDAEVAALLENFSSSYDYGENESDSCCTSPPCPQDFSLNFDRAFLPALYSLLFLLGLLGNGAVAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHCQYNFPQVGRTALRVLQLVAGFLLPLLVMAYCYAHILAVLLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESRVDVAKSVTSGLGYMHCCLNPLLYAFVGVKFRERMWMLLLRLGCPNQRGLQRQPSSSRRDSSWSETSEASYSGL 8Y0N,8Y0H,8XYK,8XYI,8XXZ,8XXY,8K2X,8HNM,8HNL,8HNK C-X-C chemokine receptor type 3 CXCR3_HUMAN P49682 B2R982 O15185 Q7Z710 Q9P2T4 Q9P2T5 555321 CN1CCN(CC1)S(=O)(=O)c1c(Cl)ccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O |w:20.21| InChI=1S/C25H29ClN4O6S2/c1-14-5-8-17(36-14)19(18-4-3-13-37-18)28-21-20(23(32)24(21)33)27-16-7-6-15(26)25(22(16)31)38(34,35)30-11-9-29(2)10-12-30/h5-8,18-19,27-28,31H,3-4,9-13H2,1-2H3 SPLGZZDGUQTEHE-UHFFFAOYSA-N 236791 US9388149, 22::US9580412, Example 22 C-C chemokine receptor type 4 Human 9.40 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236791 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7517&target=C-C+chemokine+receptor+type+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236791&enzyme=C-C+chemokine+receptor+type+4&column=ki&startPg=0&Increment=50&submit=Search 129012359 340130373 1 MNPTDIADTTLDESIYSNYYLYESIPKPCTKEGIKAFGELFLPPLYSLVFVFGLLGNSVVVLVLFKYKRLRSMTDVYLLNLAISDLLFVFSLPFWGYYAADQWVFGLGLCKMISWMYLVGFYSGIFFVMLMSIDRYLAIVHAVFSLRARTLTYGVITSLATWSVAVFASLPGFLFSTCYTERNHTYCKTKYSLNSTTWKVLSSLEINILGLVIPLGIMLFCYSMIIRTLQHCKNEKKNKAVKMIFAVVVLFLGFWTPYNIVLFLETLVELEVLQDCTFERYLDYAIQATETLAFVHCCLNPIIYFFLGEKFRKYILQLFKTCRGLFVLCQYCGLLQIYSADTPSSSYTQSTMDHDLHDAL C-C chemokine receptor type 4 CCR4_HUMAN P51679 Q9ULY6 Q9ULY7 555322 CN1CCN(CC1)S(=O)(=O)c1c(Cl)ccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O |w:20.21| InChI=1S/C25H29ClN4O6S2/c1-14-5-8-17(36-14)19(18-4-3-13-37-18)28-21-20(23(32)24(21)33)27-16-7-6-15(26)25(22(16)31)38(34,35)30-11-9-29(2)10-12-30/h5-8,18-19,27-28,31H,3-4,9-13H2,1-2H3 SPLGZZDGUQTEHE-UHFFFAOYSA-N 236791 US9388149, 22::US9580412, Example 22 C-C chemokine receptor type 6 Human 2.20 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236791 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7518&target=C-C+chemokine+receptor+type+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236791&enzyme=C-C+chemokine+receptor+type+6&column=ki&startPg=0&Increment=50&submit=Search 129012359 340130373 1 MSGESMNFSDVFDSSEDYFVSVNTSYYSVDSEMLLCSLQEVRQFSRLFVPIAYSLICVFGLLGNILVVITFAFYKKARSMTDVYLLNMAIADILFVLTLPFWAVSHATGAWVFSNATCKLLKGIYAINFNCGMLLLTCISMDRYIAIVQATKSFRLRSRTLPRSKIICLVVWGLSVIISSSTFVFNQKYNTQGSDVCEPKYQTVSEPIRWKLLMLGLELLFGFFIPLMFMIFCYTFIVKTLVQAQNSKRHKAIRVIIAVVLVFLACQIPHNMVLLVTAANLGKMNRSCQSEKLIGYTKTVTEVLAFLHCCLNPVLYAFIGQKFRNYFLKILKDLWCVRRKYKSSGFSCAGRYSENISRQTSETADNDNASSFTM 6WWZ C-C chemokine receptor type 6 CCR6_HUMAN P51684 E1P5C6 P78553 Q92846 555323 CN1CCN(CC1)S(=O)(=O)c1c(Cl)ccc(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)c1O |w:20.21| InChI=1S/C25H29ClN4O6S2/c1-14-5-8-17(36-14)19(18-4-3-13-37-18)28-21-20(23(32)24(21)33)27-16-7-6-15(26)25(22(16)31)38(34,35)30-11-9-29(2)10-12-30/h5-8,18-19,27-28,31H,3-4,9-13H2,1-2H3 SPLGZZDGUQTEHE-UHFFFAOYSA-N 236791 US9388149, 22::US9580412, Example 22 C-X-C chemokine receptor type 3 Human 150 US Patent 10.7270/Q2222WT6 aid1795852 US9580412 Musicki, B; Aubert, J; Boiteau, J; Clary, L; Rossio, P; Schuppli-Nollet, M 2/28/2017 2/19/2019 Galderma Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=236791 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=402&target=C-X-C+chemokine+receptor+type+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=236791&enzyme=C-X-C+chemokine+receptor+type+3&column=ki&startPg=0&Increment=50&submit=Search 129012359 340130373 1 MVLEVSDHQVLNDAEVAALLENFSSSYDYGENESDSCCTSPPCPQDFSLNFDRAFLPALYSLLFLLGLLGNGAVAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHCQYNFPQVGRTALRVLQLVAGFLLPLLVMAYCYAHILAVLLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESRVDVAKSVTSGLGYMHCCLNPLLYAFVGVKFRERMWMLLLRLGCPNQRGLQRQPSSSRRDSSWSETSEASYSGL 8Y0N,8Y0H,8XYK,8XYI,8XXZ,8XXY,8K2X,8HNM,8HNL,8HNK C-X-C chemokine receptor type 3 CXCR3_HUMAN P49682 B2R982 O15185 Q7Z710 Q9P2T4 Q9P2T5