BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Date of publication Date in BindingDB Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID PubChem SID ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence 1 PDB ID(s) of Target Chain 1 UniProt (SwissProt) Recommended Name of Target Chain 1 UniProt (SwissProt) Entry Name of Target Chain 1 UniProt (SwissProt) Primary ID of Target Chain 1 UniProt (SwissProt) Secondary ID(s) of Target Chain 1 UniProt (SwissProt) Alternative ID(s) of Target Chain 1 UniProt (TrEMBL) Submitted Name of Target Chain 1 UniProt (TrEMBL) Entry Name of Target Chain 1 UniProt (TrEMBL) Primary ID of Target Chain 1 UniProt (TrEMBL) Secondary ID(s) of Target Chain 1 UniProt (TrEMBL) Alternative ID(s) of Target Chain 1 BindingDB Target Chain Sequence 2 PDB ID(s) of Target Chain 2 UniProt (SwissProt) Recommended Name of Target Chain 2 UniProt (SwissProt) Entry Name of Target Chain 2 UniProt (SwissProt) Primary ID of Target Chain 2 UniProt (SwissProt) Secondary ID(s) of Target Chain 2 UniProt (SwissProt) Alternative ID(s) of Target Chain 2 UniProt (TrEMBL) Submitted Name of Target Chain 2 UniProt (TrEMBL) Entry Name of Target Chain 2 UniProt (TrEMBL) Primary ID of Target Chain 2 UniProt (TrEMBL) Secondary ID(s) of Target Chain 2 UniProt (TrEMBL) Alternative ID(s) of Target Chain 2 BindingDB Target Chain Sequence 3 PDB ID(s) of Target Chain 3 UniProt (SwissProt) Recommended Name of Target Chain 3 UniProt (SwissProt) Entry Name of Target Chain 3 UniProt (SwissProt) Primary ID of Target Chain 3 UniProt (SwissProt) Secondary ID(s) of Target Chain 3 UniProt (SwissProt) Alternative ID(s) of Target Chain 3 UniProt (TrEMBL) Submitted Name of Target Chain 3 UniProt (TrEMBL) Entry Name of Target Chain 3 UniProt (TrEMBL) Primary ID of Target Chain 3 UniProt (TrEMBL) Secondary ID(s) of Target Chain 3 UniProt (TrEMBL) Alternative ID(s) of Target Chain 3 BindingDB Target Chain Sequence 4 PDB ID(s) of Target Chain 4 UniProt (SwissProt) Recommended Name of Target Chain 4 UniProt (SwissProt) Entry Name of Target Chain 4 UniProt (SwissProt) Primary ID of Target Chain 4 UniProt (SwissProt) Secondary ID(s) of Target Chain 4 UniProt (SwissProt) Alternative ID(s) of Target Chain 4 UniProt (TrEMBL) Submitted Name of Target Chain 4 UniProt (TrEMBL) Entry Name of Target Chain 4 UniProt (TrEMBL) Primary ID of Target Chain 4 UniProt (TrEMBL) Secondary ID(s) of Target Chain 4 UniProt (TrEMBL) Alternative ID(s) of Target Chain 4 BindingDB Target Chain Sequence 5 PDB ID(s) of Target Chain 5 UniProt (SwissProt) Recommended Name of Target Chain 5 UniProt (SwissProt) Entry Name of Target Chain 5 UniProt (SwissProt) Primary ID of Target Chain 5 UniProt (SwissProt) Secondary ID(s) of Target Chain 5 UniProt (SwissProt) Alternative ID(s) of Target Chain 5 UniProt (TrEMBL) Submitted Name of Target Chain 5 UniProt (TrEMBL) Entry Name of Target Chain 5 UniProt (TrEMBL) Primary ID of Target Chain 5 UniProt (TrEMBL) Secondary ID(s) of Target Chain 5 UniProt (TrEMBL) Alternative ID(s) of Target Chain 5 BindingDB Target Chain Sequence 6 PDB ID(s) of Target Chain 6 UniProt (SwissProt) Recommended Name of Target Chain 6 UniProt (SwissProt) Entry Name of Target Chain 6 UniProt (SwissProt) Primary ID of Target Chain 6 UniProt (SwissProt) Secondary ID(s) of Target Chain 6 UniProt (SwissProt) Alternative ID(s) of Target Chain 6 UniProt (TrEMBL) Submitted Name of Target Chain 6 UniProt (TrEMBL) Entry Name of Target Chain 6 UniProt (TrEMBL) Primary ID of Target Chain 6 UniProt (TrEMBL) Secondary ID(s) of Target Chain 6 UniProt (TrEMBL) Alternative ID(s) of Target Chain 6 BindingDB Target Chain Sequence 7 PDB ID(s) of Target Chain 7 UniProt (SwissProt) Recommended Name of Target Chain 7 UniProt (SwissProt) Entry Name of Target Chain 7 UniProt (SwissProt) Primary ID of Target Chain 7 UniProt (SwissProt) Secondary ID(s) of Target Chain 7 UniProt (SwissProt) Alternative ID(s) of Target Chain 7 UniProt (TrEMBL) Submitted Name of Target Chain 7 UniProt (TrEMBL) Entry Name of Target Chain 7 UniProt (TrEMBL) Primary ID of Target Chain 7 UniProt (TrEMBL) Secondary ID(s) of Target Chain 7 UniProt (TrEMBL) Alternative ID(s) of Target Chain 7 BindingDB Target Chain Sequence 8 PDB ID(s) of Target Chain 8 UniProt (SwissProt) Recommended Name of Target Chain 8 UniProt (SwissProt) Entry Name of Target Chain 8 UniProt (SwissProt) Primary ID of Target Chain 8 UniProt (SwissProt) Secondary ID(s) of Target Chain 8 UniProt (SwissProt) Alternative ID(s) of Target Chain 8 UniProt (TrEMBL) Submitted Name of Target Chain 8 UniProt (TrEMBL) Entry Name of Target Chain 8 UniProt (TrEMBL) Primary ID of Target Chain 8 UniProt (TrEMBL) Secondary ID(s) of Target Chain 8 UniProt (TrEMBL) Alternative ID(s) of Target Chain 8 BindingDB Target Chain Sequence 9 PDB ID(s) of Target Chain 9 UniProt (SwissProt) Recommended Name of Target Chain 9 UniProt (SwissProt) Entry Name of Target Chain 9 UniProt (SwissProt) Primary ID of Target Chain 9 UniProt (SwissProt) Secondary ID(s) of Target Chain 9 UniProt (SwissProt) Alternative ID(s) of Target Chain 9 UniProt (TrEMBL) Submitted Name of Target Chain 9 UniProt (TrEMBL) Entry Name of Target Chain 9 UniProt (TrEMBL) Primary ID of Target Chain 9 UniProt (TrEMBL) Secondary ID(s) of Target Chain 9 UniProt (TrEMBL) Alternative ID(s) of Target Chain 9 BindingDB Target Chain Sequence 10 PDB ID(s) of Target Chain 10 UniProt (SwissProt) Recommended Name of Target Chain 10 UniProt (SwissProt) Entry Name of Target Chain 10 UniProt (SwissProt) Primary ID of Target Chain 10 UniProt (SwissProt) Secondary ID(s) of Target Chain 10 UniProt (SwissProt) Alternative ID(s) of Target Chain 10 UniProt (TrEMBL) Submitted Name of Target Chain 10 UniProt (TrEMBL) Entry Name of Target Chain 10 UniProt (TrEMBL) Primary ID of Target Chain 10 UniProt (TrEMBL) Secondary ID(s) of Target Chain 10 UniProt (TrEMBL) Alternative ID(s) of Target Chain 10 BindingDB Target Chain Sequence 11 PDB ID(s) of Target Chain 11 UniProt (SwissProt) Recommended Name of Target Chain 11 UniProt (SwissProt) Entry Name of Target Chain 11 UniProt (SwissProt) Primary ID of Target Chain 11 UniProt (SwissProt) Secondary ID(s) of Target Chain 11 UniProt (SwissProt) Alternative ID(s) of Target Chain 11 UniProt (TrEMBL) Submitted Name of Target Chain 11 UniProt (TrEMBL) Entry Name of Target Chain 11 UniProt (TrEMBL) Primary ID of Target Chain 11 UniProt (TrEMBL) Secondary ID(s) of Target Chain 11 UniProt (TrEMBL) Alternative ID(s) of Target Chain 11 BindingDB Target Chain Sequence 12 PDB ID(s) of Target Chain 12 UniProt (SwissProt) Recommended Name of Target Chain 12 UniProt (SwissProt) Entry Name of Target Chain 12 UniProt (SwissProt) Primary ID of Target Chain 12 UniProt (SwissProt) Secondary ID(s) of Target Chain 12 UniProt (SwissProt) Alternative ID(s) of Target Chain 12 UniProt (TrEMBL) Submitted Name of Target Chain 12 UniProt (TrEMBL) Entry Name of Target Chain 12 UniProt (TrEMBL) Primary ID of Target Chain 12 UniProt (TrEMBL) Secondary ID(s) of Target Chain 12 UniProt (TrEMBL) Alternative ID(s) of Target Chain 12 BindingDB Target Chain Sequence 13 PDB ID(s) of Target Chain 13 UniProt (SwissProt) Recommended Name of Target Chain 13 UniProt (SwissProt) Entry Name of Target Chain 13 UniProt (SwissProt) Primary ID of Target Chain 13 UniProt (SwissProt) Secondary ID(s) of Target Chain 13 UniProt (SwissProt) Alternative ID(s) of Target Chain 13 UniProt (TrEMBL) Submitted Name of Target Chain 13 UniProt (TrEMBL) Entry Name of Target Chain 13 UniProt (TrEMBL) Primary ID of Target Chain 13 UniProt (TrEMBL) Secondary ID(s) of Target Chain 13 UniProt (TrEMBL) Alternative ID(s) of Target Chain 13 BindingDB Target Chain Sequence 14 PDB ID(s) of Target Chain 14 UniProt (SwissProt) Recommended Name of Target Chain 14 UniProt (SwissProt) Entry Name of Target Chain 14 UniProt (SwissProt) Primary ID of Target Chain 14 UniProt (SwissProt) Secondary ID(s) of Target Chain 14 UniProt (SwissProt) Alternative ID(s) of Target Chain 14 UniProt (TrEMBL) Submitted Name of Target Chain 14 UniProt (TrEMBL) Entry Name of Target Chain 14 UniProt (TrEMBL) Primary ID of Target Chain 14 UniProt (TrEMBL) Secondary ID(s) of Target Chain 14 UniProt (TrEMBL) Alternative ID(s) of Target Chain 14 BindingDB Target Chain Sequence 15 PDB ID(s) of Target Chain 15 UniProt (SwissProt) Recommended Name of Target Chain 15 UniProt (SwissProt) Entry Name of Target Chain 15 UniProt (SwissProt) Primary ID of Target Chain 15 UniProt (SwissProt) Secondary ID(s) of Target Chain 15 UniProt (SwissProt) Alternative ID(s) of Target Chain 15 UniProt (TrEMBL) Submitted Name of Target Chain 15 UniProt (TrEMBL) Entry Name of Target Chain 15 UniProt (TrEMBL) Primary ID of Target Chain 15 UniProt (TrEMBL) Secondary ID(s) of Target Chain 15 UniProt (TrEMBL) Alternative ID(s) of Target Chain 15 BindingDB Target Chain Sequence 16 PDB ID(s) of Target Chain 16 UniProt (SwissProt) Recommended Name of Target Chain 16 UniProt (SwissProt) Entry Name of Target Chain 16 UniProt (SwissProt) Primary ID of Target Chain 16 UniProt (SwissProt) Secondary ID(s) of Target Chain 16 UniProt (SwissProt) Alternative ID(s) of Target Chain 16 UniProt (TrEMBL) Submitted Name of Target Chain 16 UniProt (TrEMBL) Entry Name of Target Chain 16 UniProt (TrEMBL) Primary ID of Target Chain 16 UniProt (TrEMBL) Secondary ID(s) of Target Chain 16 UniProt (TrEMBL) Alternative ID(s) of Target Chain 16 BindingDB Target Chain Sequence 17 PDB ID(s) of Target Chain 17 UniProt (SwissProt) Recommended Name of Target Chain 17 UniProt (SwissProt) Entry Name of Target Chain 17 UniProt (SwissProt) Primary ID of Target Chain 17 UniProt (SwissProt) Secondary ID(s) of Target Chain 17 UniProt (SwissProt) Alternative ID(s) of Target Chain 17 UniProt (TrEMBL) Submitted Name of Target Chain 17 UniProt (TrEMBL) Entry Name of Target Chain 17 UniProt (TrEMBL) Primary ID of Target Chain 17 UniProt (TrEMBL) Secondary ID(s) of Target Chain 17 UniProt (TrEMBL) Alternative ID(s) of Target Chain 17 BindingDB Target Chain Sequence 18 PDB ID(s) of Target Chain 18 UniProt (SwissProt) Recommended Name of Target Chain 18 UniProt (SwissProt) Entry Name of Target Chain 18 UniProt (SwissProt) Primary ID of Target Chain 18 UniProt (SwissProt) Secondary ID(s) of Target Chain 18 UniProt (SwissProt) Alternative ID(s) of Target Chain 18 UniProt (TrEMBL) Submitted Name of Target Chain 18 UniProt (TrEMBL) Entry Name of Target Chain 18 UniProt (TrEMBL) Primary ID of Target Chain 18 UniProt (TrEMBL) Secondary ID(s) of Target Chain 18 UniProt (TrEMBL) Alternative ID(s) of Target Chain 18 BindingDB Target Chain Sequence 19 PDB ID(s) of Target Chain 19 UniProt (SwissProt) Recommended Name of Target Chain 19 UniProt (SwissProt) Entry Name of Target Chain 19 UniProt (SwissProt) Primary ID of Target Chain 19 UniProt (SwissProt) Secondary ID(s) of Target Chain 19 UniProt (SwissProt) Alternative ID(s) of Target Chain 19 UniProt (TrEMBL) Submitted Name of Target Chain 19 UniProt (TrEMBL) Entry Name of Target Chain 19 UniProt (TrEMBL) Primary ID of Target Chain 19 UniProt (TrEMBL) Secondary ID(s) of Target Chain 19 UniProt (TrEMBL) Alternative ID(s) of Target Chain 19 BindingDB Target Chain Sequence 20 PDB ID(s) of Target Chain 20 UniProt (SwissProt) Recommended Name of Target Chain 20 UniProt (SwissProt) Entry Name of Target Chain 20 UniProt (SwissProt) Primary ID of Target Chain 20 UniProt (SwissProt) Secondary ID(s) of Target Chain 20 UniProt (SwissProt) Alternative ID(s) of Target Chain 20 UniProt (TrEMBL) Submitted Name of Target Chain 20 UniProt (TrEMBL) Entry Name of Target Chain 20 UniProt (TrEMBL) Primary ID of Target Chain 20 UniProt (TrEMBL) Secondary ID(s) of Target Chain 20 UniProt (TrEMBL) Alternative ID(s) of Target Chain 20 BindingDB Target Chain Sequence 21 PDB ID(s) of Target Chain 21 UniProt (SwissProt) Recommended Name of Target Chain 21 UniProt (SwissProt) Entry Name of Target Chain 21 UniProt (SwissProt) Primary ID of Target Chain 21 UniProt (SwissProt) Secondary ID(s) of Target Chain 21 UniProt (SwissProt) Alternative ID(s) of Target Chain 21 UniProt (TrEMBL) Submitted Name of Target Chain 21 UniProt (TrEMBL) Entry Name of Target Chain 21 UniProt (TrEMBL) Primary ID of Target Chain 21 UniProt (TrEMBL) Secondary ID(s) of Target Chain 21 UniProt (TrEMBL) Alternative ID(s) of Target Chain 21 BindingDB Target Chain Sequence 22 PDB ID(s) of Target Chain 22 UniProt (SwissProt) Recommended Name of Target Chain 22 UniProt (SwissProt) Entry Name of Target Chain 22 UniProt (SwissProt) Primary ID of Target Chain 22 UniProt (SwissProt) Secondary ID(s) of Target Chain 22 UniProt (SwissProt) Alternative ID(s) of Target Chain 22 UniProt (TrEMBL) Submitted Name of Target Chain 22 UniProt (TrEMBL) Entry Name of Target Chain 22 UniProt (TrEMBL) Primary ID of Target Chain 22 UniProt (TrEMBL) Secondary ID(s) of Target Chain 22 UniProt (TrEMBL) Alternative ID(s) of Target Chain 22 BindingDB Target Chain Sequence 23 PDB ID(s) of Target Chain 23 UniProt (SwissProt) Recommended Name of Target Chain 23 UniProt (SwissProt) Entry Name of Target Chain 23 UniProt (SwissProt) Primary ID of Target Chain 23 UniProt (SwissProt) Secondary ID(s) of Target Chain 23 UniProt (SwissProt) Alternative ID(s) of Target Chain 23 UniProt (TrEMBL) Submitted Name of Target Chain 23 UniProt (TrEMBL) Entry Name of Target Chain 23 UniProt (TrEMBL) Primary ID of Target Chain 23 UniProt (TrEMBL) Secondary ID(s) of Target Chain 23 UniProt (TrEMBL) Alternative ID(s) of Target Chain 23 BindingDB Target Chain Sequence 24 PDB ID(s) of Target Chain 24 UniProt (SwissProt) Recommended Name of Target Chain 24 UniProt (SwissProt) Entry Name of Target Chain 24 UniProt (SwissProt) Primary ID of Target Chain 24 UniProt (SwissProt) Secondary ID(s) of Target Chain 24 UniProt (SwissProt) Alternative ID(s) of Target Chain 24 UniProt (TrEMBL) Submitted Name of Target Chain 24 UniProt (TrEMBL) Entry Name of Target Chain 24 UniProt (TrEMBL) Primary ID of Target Chain 24 UniProt (TrEMBL) Secondary ID(s) of Target Chain 24 UniProt (TrEMBL) Alternative ID(s) of Target Chain 24 BindingDB Target Chain Sequence 25 PDB ID(s) of Target Chain 25 UniProt (SwissProt) Recommended Name of Target Chain 25 UniProt (SwissProt) Entry Name of Target Chain 25 UniProt (SwissProt) Primary ID of Target Chain 25 UniProt (SwissProt) Secondary ID(s) of Target Chain 25 UniProt (SwissProt) Alternative ID(s) of Target Chain 25 UniProt (TrEMBL) Submitted Name of Target Chain 25 UniProt (TrEMBL) Entry Name of Target Chain 25 UniProt (TrEMBL) Primary ID of Target Chain 25 UniProt (TrEMBL) Secondary ID(s) of Target Chain 25 UniProt (TrEMBL) Alternative ID(s) of Target Chain 25 BindingDB Target Chain Sequence 26 PDB ID(s) of Target Chain 26 UniProt (SwissProt) Recommended Name of Target Chain 26 UniProt (SwissProt) Entry Name of Target Chain 26 UniProt (SwissProt) Primary ID of Target Chain 26 UniProt (SwissProt) Secondary ID(s) of Target Chain 26 UniProt (SwissProt) Alternative ID(s) of Target Chain 26 UniProt (TrEMBL) Submitted Name of Target Chain 26 UniProt (TrEMBL) Entry Name of Target Chain 26 UniProt (TrEMBL) Primary ID of Target Chain 26 UniProt (TrEMBL) Secondary ID(s) of Target Chain 26 UniProt (TrEMBL) Alternative ID(s) of Target Chain 26 BindingDB Target Chain Sequence 27 PDB ID(s) of Target Chain 27 UniProt (SwissProt) Recommended Name of Target Chain 27 UniProt (SwissProt) Entry Name of Target Chain 27 UniProt (SwissProt) Primary ID of Target Chain 27 UniProt (SwissProt) Secondary ID(s) of Target Chain 27 UniProt (SwissProt) Alternative ID(s) of Target Chain 27 UniProt (TrEMBL) Submitted Name of Target Chain 27 UniProt (TrEMBL) Entry Name of Target Chain 27 UniProt (TrEMBL) Primary ID of Target Chain 27 UniProt (TrEMBL) Secondary ID(s) of Target Chain 27 UniProt (TrEMBL) Alternative ID(s) of Target Chain 27 BindingDB Target Chain Sequence 28 PDB ID(s) of Target Chain 28 UniProt (SwissProt) Recommended Name of Target Chain 28 UniProt (SwissProt) Entry Name of Target Chain 28 UniProt (SwissProt) Primary ID of Target Chain 28 UniProt (SwissProt) Secondary ID(s) of Target Chain 28 UniProt (SwissProt) Alternative ID(s) of Target Chain 28 UniProt (TrEMBL) Submitted Name of Target Chain 28 UniProt (TrEMBL) Entry Name of Target Chain 28 UniProt (TrEMBL) Primary ID of Target Chain 28 UniProt (TrEMBL) Secondary ID(s) of Target Chain 28 UniProt (TrEMBL) Alternative ID(s) of Target Chain 28 BindingDB Target Chain Sequence 29 PDB ID(s) of Target Chain 29 UniProt (SwissProt) Recommended Name of Target Chain 29 UniProt (SwissProt) Entry Name of Target Chain 29 UniProt (SwissProt) Primary ID of Target Chain 29 UniProt (SwissProt) Secondary ID(s) of Target Chain 29 UniProt (SwissProt) Alternative ID(s) of Target Chain 29 UniProt (TrEMBL) Submitted Name of Target Chain 29 UniProt (TrEMBL) Entry Name of Target Chain 29 UniProt (TrEMBL) Primary ID of Target Chain 29 UniProt (TrEMBL) Secondary ID(s) of Target Chain 29 UniProt (TrEMBL) Alternative ID(s) of Target Chain 29 BindingDB Target Chain Sequence 30 PDB ID(s) of Target Chain 30 UniProt (SwissProt) Recommended Name of Target Chain 30 UniProt (SwissProt) Entry Name of Target Chain 30 UniProt (SwissProt) Primary ID of Target Chain 30 UniProt (SwissProt) Secondary ID(s) of Target Chain 30 UniProt (SwissProt) Alternative ID(s) of Target Chain 30 UniProt (TrEMBL) Submitted Name of Target Chain 30 UniProt (TrEMBL) Entry Name of Target Chain 30 UniProt (TrEMBL) Primary ID of Target Chain 30 UniProt (TrEMBL) Secondary ID(s) of Target Chain 30 UniProt (TrEMBL) Alternative ID(s) of Target Chain 30 BindingDB Target Chain Sequence 31 PDB ID(s) of Target Chain 31 UniProt (SwissProt) Recommended Name of Target Chain 31 UniProt (SwissProt) Entry Name of Target Chain 31 UniProt (SwissProt) Primary ID of Target Chain 31 UniProt (SwissProt) Secondary ID(s) of Target Chain 31 UniProt (SwissProt) Alternative ID(s) of Target Chain 31 UniProt (TrEMBL) Submitted Name of Target Chain 31 UniProt (TrEMBL) Entry Name of Target Chain 31 UniProt (TrEMBL) Primary ID of Target Chain 31 UniProt (TrEMBL) Secondary ID(s) of Target Chain 31 UniProt (TrEMBL) Alternative ID(s) of Target Chain 31 BindingDB Target Chain Sequence 32 PDB ID(s) of Target Chain 32 UniProt (SwissProt) Recommended Name of Target Chain 32 UniProt (SwissProt) Entry Name of Target Chain 32 UniProt (SwissProt) Primary ID of Target Chain 32 UniProt (SwissProt) Secondary ID(s) of Target Chain 32 UniProt (SwissProt) Alternative ID(s) of Target Chain 32 UniProt (TrEMBL) Submitted Name of Target Chain 32 UniProt (TrEMBL) Entry Name of Target Chain 32 UniProt (TrEMBL) Primary ID of Target Chain 32 UniProt (TrEMBL) Secondary ID(s) of Target Chain 32 UniProt (TrEMBL) Alternative ID(s) of Target Chain 32 BindingDB Target Chain Sequence 33 PDB ID(s) of Target Chain 33 UniProt (SwissProt) Recommended Name of Target Chain 33 UniProt (SwissProt) Entry Name of Target Chain 33 UniProt (SwissProt) Primary ID of Target Chain 33 UniProt (SwissProt) Secondary ID(s) of Target Chain 33 UniProt (SwissProt) Alternative ID(s) of Target Chain 33 UniProt (TrEMBL) Submitted Name of Target Chain 33 UniProt (TrEMBL) Entry Name of Target Chain 33 UniProt (TrEMBL) Primary ID of Target Chain 33 UniProt (TrEMBL) Secondary ID(s) of Target Chain 33 UniProt (TrEMBL) Alternative ID(s) of Target Chain 33 BindingDB Target Chain Sequence 34 PDB ID(s) of Target Chain 34 UniProt (SwissProt) Recommended Name of Target Chain 34 UniProt (SwissProt) Entry Name of Target Chain 34 UniProt (SwissProt) Primary ID of Target Chain 34 UniProt (SwissProt) Secondary ID(s) of Target Chain 34 UniProt (SwissProt) Alternative ID(s) of Target Chain 34 UniProt (TrEMBL) Submitted Name of Target Chain 34 UniProt (TrEMBL) Entry Name of Target Chain 34 UniProt (TrEMBL) Primary ID of Target Chain 34 UniProt (TrEMBL) Secondary ID(s) of Target Chain 34 UniProt (TrEMBL) Alternative ID(s) of Target Chain 34 BindingDB Target Chain Sequence 35 PDB ID(s) of Target Chain 35 UniProt (SwissProt) Recommended Name of Target Chain 35 UniProt (SwissProt) Entry Name of Target Chain 35 UniProt (SwissProt) Primary ID of Target Chain 35 UniProt (SwissProt) Secondary ID(s) of Target Chain 35 UniProt (SwissProt) Alternative ID(s) of Target Chain 35 UniProt (TrEMBL) Submitted Name of Target Chain 35 UniProt (TrEMBL) Entry Name of Target Chain 35 UniProt (TrEMBL) Primary ID of Target Chain 35 UniProt (TrEMBL) Secondary ID(s) of Target Chain 35 UniProt (TrEMBL) Alternative ID(s) of Target Chain 35 BindingDB Target Chain Sequence 36 PDB ID(s) of Target Chain 36 UniProt (SwissProt) Recommended Name of Target Chain 36 UniProt (SwissProt) Entry Name of Target Chain 36 UniProt (SwissProt) Primary ID of Target Chain 36 UniProt (SwissProt) Secondary ID(s) of Target Chain 36 UniProt (SwissProt) Alternative ID(s) of Target Chain 36 UniProt (TrEMBL) Submitted Name of Target Chain 36 UniProt (TrEMBL) Entry Name of Target Chain 36 UniProt (TrEMBL) Primary ID of Target Chain 36 UniProt (TrEMBL) Secondary ID(s) of Target Chain 36 UniProt (TrEMBL) Alternative ID(s) of Target Chain 36 BindingDB Target Chain Sequence 37 PDB ID(s) of Target Chain 37 UniProt (SwissProt) Recommended Name of Target Chain 37 UniProt (SwissProt) Entry Name of Target Chain 37 UniProt (SwissProt) Primary ID of Target Chain 37 UniProt (SwissProt) Secondary ID(s) of Target Chain 37 UniProt (SwissProt) Alternative ID(s) of Target Chain 37 UniProt (TrEMBL) Submitted Name of Target Chain 37 UniProt (TrEMBL) Entry Name of Target Chain 37 UniProt (TrEMBL) Primary ID of Target Chain 37 UniProt (TrEMBL) Secondary ID(s) of Target Chain 37 UniProt (TrEMBL) Alternative ID(s) of Target Chain 37 BindingDB Target Chain Sequence 38 PDB ID(s) of Target Chain 38 UniProt (SwissProt) Recommended Name of Target Chain 38 UniProt (SwissProt) Entry Name of Target Chain 38 UniProt (SwissProt) Primary ID of Target Chain 38 UniProt (SwissProt) Secondary ID(s) of Target Chain 38 UniProt (SwissProt) Alternative ID(s) of Target Chain 38 UniProt (TrEMBL) Submitted Name of Target Chain 38 UniProt (TrEMBL) Entry Name of Target Chain 38 UniProt (TrEMBL) Primary ID of Target Chain 38 UniProt (TrEMBL) Secondary ID(s) of Target Chain 38 UniProt (TrEMBL) Alternative ID(s) of Target Chain 38 BindingDB Target Chain Sequence 39 PDB ID(s) of Target Chain 39 UniProt (SwissProt) Recommended Name of Target Chain 39 UniProt (SwissProt) Entry Name of Target Chain 39 UniProt (SwissProt) Primary ID of Target Chain 39 UniProt (SwissProt) Secondary ID(s) of Target Chain 39 UniProt (SwissProt) Alternative ID(s) of Target Chain 39 UniProt (TrEMBL) Submitted Name of Target Chain 39 UniProt (TrEMBL) Entry Name of Target Chain 39 UniProt (TrEMBL) Primary ID of Target Chain 39 UniProt (TrEMBL) Secondary ID(s) of Target Chain 39 UniProt (TrEMBL) Alternative ID(s) of Target Chain 39 BindingDB Target Chain Sequence 40 PDB ID(s) of Target Chain 40 UniProt (SwissProt) Recommended Name of Target Chain 40 UniProt (SwissProt) Entry Name of Target Chain 40 UniProt (SwissProt) Primary ID of Target Chain 40 UniProt (SwissProt) Secondary ID(s) of Target Chain 40 UniProt (SwissProt) Alternative ID(s) of Target Chain 40 UniProt (TrEMBL) Submitted Name of Target Chain 40 UniProt (TrEMBL) Entry Name of Target Chain 40 UniProt (TrEMBL) Primary ID of Target Chain 40 UniProt (TrEMBL) Secondary ID(s) of Target Chain 40 UniProt (TrEMBL) Alternative ID(s) of Target Chain 40 BindingDB Target Chain Sequence 41 PDB ID(s) of Target Chain 41 UniProt (SwissProt) Recommended Name of Target Chain 41 UniProt (SwissProt) Entry Name of Target Chain 41 UniProt (SwissProt) Primary ID of Target Chain 41 UniProt (SwissProt) Secondary ID(s) of Target Chain 41 UniProt (SwissProt) Alternative ID(s) of Target Chain 41 UniProt (TrEMBL) Submitted Name of Target Chain 41 UniProt (TrEMBL) Entry Name of Target Chain 41 UniProt (TrEMBL) Primary ID of Target Chain 41 UniProt (TrEMBL) Secondary ID(s) of Target Chain 41 UniProt (TrEMBL) Alternative ID(s) of Target Chain 41 BindingDB Target Chain Sequence 42 PDB ID(s) of Target Chain 42 UniProt (SwissProt) Recommended Name of Target Chain 42 UniProt (SwissProt) Entry Name of Target Chain 42 UniProt (SwissProt) Primary ID of Target Chain 42 UniProt (SwissProt) Secondary ID(s) of Target Chain 42 UniProt (SwissProt) Alternative ID(s) of Target Chain 42 UniProt (TrEMBL) Submitted Name of Target Chain 42 UniProt (TrEMBL) Entry Name of Target Chain 42 UniProt (TrEMBL) Primary ID of Target Chain 42 UniProt (TrEMBL) Secondary ID(s) of Target Chain 42 UniProt (TrEMBL) Alternative ID(s) of Target Chain 42 BindingDB Target Chain Sequence 43 PDB ID(s) of Target Chain 43 UniProt (SwissProt) Recommended Name of Target Chain 43 UniProt (SwissProt) Entry Name of Target Chain 43 UniProt (SwissProt) Primary ID of Target Chain 43 UniProt (SwissProt) Secondary ID(s) of Target Chain 43 UniProt (SwissProt) Alternative ID(s) of Target Chain 43 UniProt (TrEMBL) Submitted Name of Target Chain 43 UniProt (TrEMBL) Entry Name of Target Chain 43 UniProt (TrEMBL) Primary ID of Target Chain 43 UniProt (TrEMBL) Secondary ID(s) of Target Chain 43 UniProt (TrEMBL) Alternative ID(s) of Target Chain 43 BindingDB Target Chain Sequence 44 PDB ID(s) of Target Chain 44 UniProt (SwissProt) Recommended Name of Target Chain 44 UniProt (SwissProt) Entry Name of Target Chain 44 UniProt (SwissProt) Primary ID of Target Chain 44 UniProt (SwissProt) Secondary ID(s) of Target Chain 44 UniProt (SwissProt) Alternative ID(s) of Target Chain 44 UniProt (TrEMBL) Submitted Name of Target Chain 44 UniProt (TrEMBL) Entry Name of Target Chain 44 UniProt (TrEMBL) Primary ID of Target Chain 44 UniProt (TrEMBL) Secondary ID(s) of Target Chain 44 UniProt (TrEMBL) Alternative ID(s) of Target Chain 44 BindingDB Target Chain Sequence 45 PDB ID(s) of Target Chain 45 UniProt (SwissProt) Recommended Name of Target Chain 45 UniProt (SwissProt) Entry Name of Target Chain 45 UniProt (SwissProt) Primary ID of Target Chain 45 UniProt (SwissProt) Secondary ID(s) of Target Chain 45 UniProt (SwissProt) Alternative ID(s) of Target Chain 45 UniProt (TrEMBL) Submitted Name of Target Chain 45 UniProt (TrEMBL) Entry Name of Target Chain 45 UniProt (TrEMBL) Primary ID of Target Chain 45 UniProt (TrEMBL) Secondary ID(s) of Target Chain 45 UniProt (TrEMBL) Alternative ID(s) of Target Chain 45 BindingDB Target Chain Sequence 46 PDB ID(s) of Target Chain 46 UniProt (SwissProt) Recommended Name of Target Chain 46 UniProt (SwissProt) Entry Name of Target Chain 46 UniProt (SwissProt) Primary ID of Target Chain 46 UniProt (SwissProt) Secondary ID(s) of Target Chain 46 UniProt (SwissProt) Alternative ID(s) of Target Chain 46 UniProt (TrEMBL) Submitted Name of Target Chain 46 UniProt (TrEMBL) Entry Name of Target Chain 46 UniProt (TrEMBL) Primary ID of Target Chain 46 UniProt (TrEMBL) Secondary ID(s) of Target Chain 46 UniProt (TrEMBL) Alternative ID(s) of Target Chain 46 BindingDB Target Chain Sequence 47 PDB ID(s) of Target Chain 47 UniProt (SwissProt) Recommended Name of Target Chain 47 UniProt (SwissProt) Entry Name of Target Chain 47 UniProt (SwissProt) Primary ID of Target Chain 47 UniProt (SwissProt) Secondary ID(s) of Target Chain 47 UniProt (SwissProt) Alternative ID(s) of Target Chain 47 UniProt (TrEMBL) Submitted Name of Target Chain 47 UniProt (TrEMBL) Entry Name of Target Chain 47 UniProt (TrEMBL) Primary ID of Target Chain 47 UniProt (TrEMBL) Secondary ID(s) of Target Chain 47 UniProt (TrEMBL) Alternative ID(s) of Target Chain 47 BindingDB Target Chain Sequence 48 PDB ID(s) of Target Chain 48 UniProt (SwissProt) Recommended Name of Target Chain 48 UniProt (SwissProt) Entry Name of Target Chain 48 UniProt (SwissProt) Primary ID of Target Chain 48 UniProt (SwissProt) Secondary ID(s) of Target Chain 48 UniProt (SwissProt) Alternative ID(s) of Target Chain 48 UniProt (TrEMBL) Submitted Name of Target Chain 48 UniProt (TrEMBL) Entry Name of Target Chain 48 UniProt (TrEMBL) Primary ID of Target Chain 48 UniProt (TrEMBL) Secondary ID(s) of Target Chain 48 UniProt (TrEMBL) Alternative ID(s) of Target Chain 48 BindingDB Target Chain Sequence 49 PDB ID(s) of Target Chain 49 UniProt (SwissProt) Recommended Name of Target Chain 49 UniProt (SwissProt) Entry Name of Target Chain 49 UniProt (SwissProt) Primary ID of Target Chain 49 UniProt (SwissProt) Secondary ID(s) of Target Chain 49 UniProt (SwissProt) Alternative ID(s) of Target Chain 49 UniProt (TrEMBL) Submitted Name of Target Chain 49 UniProt (TrEMBL) Entry Name of Target Chain 49 UniProt (TrEMBL) Primary ID of Target Chain 49 UniProt (TrEMBL) Secondary ID(s) of Target Chain 49 UniProt (TrEMBL) Alternative ID(s) of Target Chain 49 BindingDB Target Chain Sequence 50 PDB ID(s) of Target Chain 50 UniProt (SwissProt) Recommended Name of Target Chain 50 UniProt (SwissProt) Entry Name of Target Chain 50 UniProt (SwissProt) Primary ID of Target Chain 50 UniProt (SwissProt) Secondary ID(s) of Target Chain 50 UniProt (SwissProt) Alternative ID(s) of Target Chain 50 UniProt (TrEMBL) Submitted Name of Target Chain 50 UniProt (TrEMBL) Entry Name of Target Chain 50 UniProt (TrEMBL) Primary ID of Target Chain 50 UniProt (TrEMBL) Secondary ID(s) of Target Chain 50 UniProt (TrEMBL) Alternative ID(s) of Target Chain 50 494461 CC(C)Nc1nc2CN(CCc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(=O)C1CC1 InChI=1S/C25H31F2N5O2/c1-15(2)28-23-24(30-20-9-12-32(14-21(20)29-23)25(33)16-3-4-16)31-10-7-18(8-11-31)34-22-6-5-17(26)13-19(22)27/h5-6,13,15-16,18H,3-4,7-12,14H2,1-2H3,(H,28,29) ZKLYYZDTQTVTEO-UHFFFAOYSA-N 190890 US10077266, Example 1::US9181249, 1::US9708313, 1 G-protein coupled receptor 6 Human 340200 US Patent 10.7270/Q2ZP4858 aid1795209 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190890 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190890&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159281 316936160 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494462 COCC(=O)N1CCc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(NC(C)C)nc2C1 InChI=1S/C24H31F2N5O3/c1-15(2)27-23-24(29-19-8-11-31(13-20(19)28-23)22(32)14-33-3)30-9-6-17(7-10-30)34-21-5-4-16(25)12-18(21)26/h4-5,12,15,17H,6-11,13-14H2,1-3H3,(H,27,28) WIDYNDYFLUIBHH-UHFFFAOYSA-N 190891 US10077266, Example 2::US9181249, 2::US9708313, 2 G-protein coupled receptor 6 Human 71500 US Patent 10.7270/Q2ZP4858 aid1795209 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190891 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190891&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159376 316936161 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494463 CC(C)Nc1nc2CN(CCc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)S(C)(=O)=O InChI=1S/C22H29F2N5O3S/c1-14(2)25-21-22(27-18-8-11-29(33(3,30)31)13-19(18)26-21)28-9-6-16(7-10-28)32-20-5-4-15(23)12-17(20)24/h4-5,12,14,16H,6-11,13H2,1-3H3,(H,25,26) ZQSQANVLMIZGFW-UHFFFAOYSA-N 190892 US10077266, Example 3::US9181249, 3::US9708313, 3 G-protein coupled receptor 6 Human 61800 US Patent 10.7270/Q2ZP4858 aid1795209 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190892 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190892&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159255 316936162 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494464 COCCNC(=O)N1CCc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(NC(C)C)nc2C1 InChI=1S/C25H34F2N6O3/c1-16(2)29-23-24(31-20-8-12-33(15-21(20)30-23)25(34)28-9-13-35-3)32-10-6-18(7-11-32)36-22-5-4-17(26)14-19(22)27/h4-5,14,16,18H,6-13,15H2,1-3H3,(H,28,34)(H,29,30) SZPUFGYPZNGJJQ-UHFFFAOYSA-N 190893 US10077266, Example 4::US9181249, 4::US9708313, 4 G-protein coupled receptor 6 Human 29800 US Patent 10.7270/Q2ZP4858 aid1795210 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190893 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190893&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159334 316936163 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494465 CC(C)Nc1nc2CN(CCc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(=O)C1CCCO1 InChI=1S/C26H33F2N5O3/c1-16(2)29-24-25(32-10-7-18(8-11-32)36-22-6-5-17(27)14-19(22)28)31-20-9-12-33(15-21(20)30-24)26(34)23-4-3-13-35-23/h5-6,14,16,18,23H,3-4,7-13,15H2,1-2H3,(H,29,30) AJZJCRXVQJNSPO-UHFFFAOYSA-N 190894 US10077266, Example 5::US9181249, 5::US9708313, 5 G-protein coupled receptor 6 Human 17900 US Patent 10.7270/Q2ZP4858 aid1795210 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190894 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190894&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159231 316936164 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494466 CC(C)Nc1nc2CN(CCc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(=O)CC#N InChI=1S/C24H28F2N6O2/c1-15(2)28-23-24(30-19-8-12-32(14-20(19)29-23)22(33)5-9-27)31-10-6-17(7-11-31)34-21-4-3-16(25)13-18(21)26/h3-4,13,15,17H,5-8,10-12,14H2,1-2H3,(H,28,29) SSSAAZHGVHRQMQ-UHFFFAOYSA-N 190895 US10077266, Example 6::US9181249, 6::US9708313, 6 G-protein coupled receptor 6 Human 55200 US Patent 10.7270/Q2ZP4858 aid1795210 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190895 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190895&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159267 316936165 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494467 CC(C)Nc1nc2CN(CCc2nc1N1CCC(CC1)Oc1ccc(cc1F)C#N)C(C)=O InChI=1S/C24H29FN6O2/c1-15(2)27-23-24(29-20-8-11-31(16(3)32)14-21(20)28-23)30-9-6-18(7-10-30)33-22-5-4-17(13-26)12-19(22)25/h4-5,12,15,18H,6-11,14H2,1-3H3,(H,27,28) BNLZKWDQCXRTAO-UHFFFAOYSA-N 190896 US10077266, Example 7::US9181249, 7::US9708313, 7 G-protein coupled receptor 6 Human 86600 US Patent 10.7270/Q2ZP4858 aid1795210 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190896 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190896&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159242 316936166 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494468 COC(C)C(=O)N1CCc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(NC(C)C)nc2C1 InChI=1S/C25H33F2N5O3/c1-15(2)28-23-24(30-20-9-12-32(14-21(20)29-23)25(33)16(3)34-4)31-10-7-18(8-11-31)35-22-6-5-17(26)13-19(22)27/h5-6,13,15-16,18H,7-12,14H2,1-4H3,(H,28,29) KXQNHPZOMZYWLT-UHFFFAOYSA-N 190897 US10077266, Example 8::US9181249, 8::US9708313, 8 G-protein coupled receptor 6 Human 16800 US Patent 10.7270/Q2ZP4858 aid1795210 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190897 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190897&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159339 316936167 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494469 CC(C)Nc1nc2CCN(Cc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(=O)C1CC1 InChI=1S/C25H31F2N5O2/c1-15(2)28-23-24(30-21-14-32(12-9-20(21)29-23)25(33)16-3-4-16)31-10-7-18(8-11-31)34-22-6-5-17(26)13-19(22)27/h5-6,13,15-16,18H,3-4,7-12,14H2,1-2H3,(H,28,29) VLLGLEYIWFYQHB-UHFFFAOYSA-N 190898 US10077266, Example 9::US9181249, 9::US9708313, 9 G-protein coupled receptor 6 Human 210600 US Patent 10.7270/Q2ZP4858 aid1795209 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190898 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190898&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159331 316936168 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494470 COCC(=O)N1CCc2nc(NC(C)C)c(nc2C1)N1CCC(CC1)Oc1ccc(F)cc1F InChI=1S/C24H31F2N5O3/c1-15(2)27-23-24(29-20-13-31(22(32)14-33-3)11-8-19(20)28-23)30-9-6-17(7-10-30)34-21-5-4-16(25)12-18(21)26/h4-5,12,15,17H,6-11,13-14H2,1-3H3,(H,27,28) MBPOFZZJKYHBRS-UHFFFAOYSA-N 190899 US10077266, Example 10::US9181249, 10::US9708313, 10 G-protein coupled receptor 6 Human 17300 US Patent 10.7270/Q2ZP4858 aid1795210 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190899 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190899&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159392 316936169 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494471 CC(C)Nc1nc2CCN(Cc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)S(C)(=O)=O InChI=1S/C22H29F2N5O3S/c1-14(2)25-21-22(27-19-13-29(33(3,30)31)11-8-18(19)26-21)28-9-6-16(7-10-28)32-20-5-4-15(23)12-17(20)24/h4-5,12,14,16H,6-11,13H2,1-3H3,(H,25,26) VQFOAKIXIWJRKV-UHFFFAOYSA-N 190900 US10077266, Example 11::US9181249, 11::US9708313, 11 G-protein coupled receptor 6 Human 95600 US Patent 10.7270/Q2ZP4858 aid1795209 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190900 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190900&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159315 316936170 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494472 CC(C)Nc1nc2CN(CCc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(=O)N1CCOCC1 InChI=1S/C26H34F2N6O3/c1-17(2)29-24-25(32-8-5-19(6-9-32)37-23-4-3-18(27)15-20(23)28)31-21-7-10-34(16-22(21)30-24)26(35)33-11-13-36-14-12-33/h3-4,15,17,19H,5-14,16H2,1-2H3,(H,29,30) KISNBNRVWTUUOQ-UHFFFAOYSA-N 261909 (2-(4-(2,4-difluorophenoxy)piperidin-1-yl)-3-(isopropylamino)-7,8-dihydropyrido[3,4-b]pyrazin-6(5H)-yl)(morpholino)methanone::US10077266, Example 14::US9708313, 14 G-protein coupled receptor 6 Human 62600 US Patent 10.7270/Q2ZP4858 aid1795210 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=261909 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=261909&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159248 376223747 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494473 COCCNC(=O)N1CCc2nc(NC(C)C)c(nc2C1)N1CCC(CC1)Oc1ccc(F)cc1F InChI=1S/C25H34F2N6O3/c1-16(2)29-23-24(31-21-15-33(12-8-20(21)30-23)25(34)28-9-13-35-3)32-10-6-18(7-11-32)36-22-5-4-17(26)14-19(22)27/h4-5,14,16,18H,6-13,15H2,1-3H3,(H,28,34)(H,29,30) XZFFAYWJIHTJHD-UHFFFAOYSA-N 190904 US10077266, Example 15::US9181249, 15::US9708313, 15 G-protein coupled receptor 6 Human 14900 US Patent 10.7270/Q2ZP4858 aid1795210 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190904 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190904&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159221 316936172 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494474 CC(C)Nc1nc2CCN(Cc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(=O)C1CCCO1 InChI=1S/C26H33F2N5O3/c1-16(2)29-24-25(32-10-7-18(8-11-32)36-22-6-5-17(27)14-19(22)28)31-21-15-33(12-9-20(21)30-24)26(34)23-4-3-13-35-23/h5-6,14,16,18,23H,3-4,7-13,15H2,1-2H3,(H,29,30) PALVWWQQDNDOFZ-UHFFFAOYSA-N 190905 US10077266, Example 16::US9181249, 16::US9708313, 16 G-protein coupled receptor 6 Human 19500 US Patent 10.7270/Q2ZP4858 aid1795210 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190905 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190905&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159203 316936173 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494475 CC(C)Nc1nc2CCN(Cc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(=O)CC#N InChI=1S/C24H28F2N6O2/c1-15(2)28-23-24(30-20-14-32(22(33)5-9-27)12-8-19(20)29-23)31-10-6-17(7-11-31)34-21-4-3-16(25)13-18(21)26/h3-4,13,15,17H,5-8,10-12,14H2,1-2H3,(H,28,29) MEZHRZNUBYRNCA-UHFFFAOYSA-N 190906 US10077266, Example 17::US9181249, 17::US9708313, 17 G-protein coupled receptor 6 Human 18000 US Patent 10.7270/Q2ZP4858 aid1795210 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190906 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190906&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159337 316936174 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494476 CC(C)Nc1nc2CN(CCc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(=O)c1ccno1 InChI=1S/C25H28F2N6O3/c1-15(2)29-23-24(32-10-6-17(7-11-32)35-21-4-3-16(26)13-18(21)27)31-19-8-12-33(14-20(19)30-23)25(34)22-5-9-28-36-22/h3-5,9,13,15,17H,6-8,10-12,14H2,1-2H3,(H,29,30) DFRPGOORGHJXGT-UHFFFAOYSA-N 190907 US10077266, Example 18::US9181249, 18::US9708313, 18 G-protein coupled receptor 6 Human 38700 US Patent 10.7270/Q2ZP4858 aid1795210 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190907 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190907&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159320 316936175 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494477 CC(C)Nc1nc2CCN(Cc2nc1N1CCC(CC1)Oc1ccc(cc1F)C#N)C(C)=O InChI=1S/C24H29FN6O2/c1-15(2)27-23-24(29-21-14-31(16(3)32)11-8-20(21)28-23)30-9-6-18(7-10-30)33-22-5-4-17(13-26)12-19(22)25/h4-5,12,15,18H,6-11,14H2,1-3H3,(H,27,28) QHAYDSAORNBIBU-UHFFFAOYSA-N 190908 US10077266, Example 19::US9181249, 19::US9708313, 19 G-protein coupled receptor 6 Human 105000 US Patent 10.7270/Q2ZP4858 aid1795210 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190908 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190908&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159386 316936176 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494478 CC(C)Nc1nc2CCN(Cc2nc1N1CCC(CC1)Oc1ccc(cc1F)C#N)C(=O)C1CC1 InChI=1S/C26H31FN6O2/c1-16(2)29-24-25(31-22-15-33(12-9-21(22)30-24)26(34)18-4-5-18)32-10-7-19(8-11-32)35-23-6-3-17(14-28)13-20(23)27/h3,6,13,16,18-19H,4-5,7-12,15H2,1-2H3,(H,29,30) AUPDVTRYLMDISN-UHFFFAOYSA-N 190909 US10077266, Example 20::US9181249, 20::US9708313, 20 G-protein coupled receptor 6 Human 122000 US Patent 10.7270/Q2ZP4858 aid1795210 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190909 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190909&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159302 316936177 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494479 CC(C)Nc1nc2CN(CCc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)S(=O)(=O)C(C)C InChI=1S/C24H33F2N5O3S/c1-15(2)27-23-24(29-20-9-12-31(14-21(20)28-23)35(32,33)16(3)4)30-10-7-18(8-11-30)34-22-6-5-17(25)13-19(22)26/h5-6,13,15-16,18H,7-12,14H2,1-4H3,(H,27,28) XURDILLHQQNFLW-UHFFFAOYSA-N 190910 US10077266, Example 21::US9181249, 21::US9708313, 21 G-protein coupled receptor 6 Human 149000 US Patent 10.7270/Q2ZP4858 aid1795210 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190910 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190910&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159371 316936178 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494480 CC(C)Nc1nc2CN(CCc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(=O)[C@@H]1CCCN1C InChI=1S/C27H36F2N6O2/c1-17(2)30-25-26(34-12-8-19(9-13-34)37-24-7-6-18(28)15-20(24)29)32-21-10-14-35(16-22(21)31-25)27(36)23-5-4-11-33(23)3/h6-7,15,17,19,23H,4-5,8-14,16H2,1-3H3,(H,30,31)/t23-/m0/s1 FOEDAKAYIRFINY-QHCPKHFHSA-N 190911 US10077266, Example 22::US9181249, 22::US9708313, 22 G-protein coupled receptor 6 Human 78100 US Patent 10.7270/Q2ZP4858 aid1795209 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190911 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190911&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159140 316936179 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494481 CC(C)Nc1nc2CN(CCc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(=O)N1CCCC1 InChI=1S/C26H34F2N6O2/c1-17(2)29-24-25(32-12-7-19(8-13-32)36-23-6-5-18(27)15-20(23)28)31-21-9-14-34(16-22(21)30-24)26(35)33-10-3-4-11-33/h5-6,15,17,19H,3-4,7-14,16H2,1-2H3,(H,29,30) OMKDIIHTEGCEDV-UHFFFAOYSA-N 190912 US10077266, Example 23::US9181249, 23::US9708313, 23 G-protein coupled receptor 6 Human 391000 US Patent 10.7270/Q2ZP4858 aid1795210 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190912 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190912&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159228 316936180 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494482 CC(C)Nc1nc2CN(CCc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(=O)C(F)F InChI=1S/C23H27F4N5O2/c1-13(2)28-21-22(30-17-7-10-32(12-18(17)29-21)23(33)20(26)27)31-8-5-15(6-9-31)34-19-4-3-14(24)11-16(19)25/h3-4,11,13,15,20H,5-10,12H2,1-2H3,(H,28,29) KKVIHTPXMOCKPD-UHFFFAOYSA-N 190913 US10077266, Example 24::US9181249, 24::US9708313, 24 G-protein coupled receptor 6 Human 129200 US Patent 10.7270/Q2ZP4858 aid1795209 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190913 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190913&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159269 316936181 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494483 CC1N(CCc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(NCC(F)F)nc12)C(C)=O InChI=1S/C23H27F4N5O2/c1-13-21-18(7-10-32(13)14(2)33)29-23(22(30-21)28-12-20(26)27)31-8-5-16(6-9-31)34-19-4-3-15(24)11-17(19)25/h3-4,11,13,16,20H,5-10,12H2,1-2H3,(H,28,30) DEVKCOJYOBVAJW-UHFFFAOYSA-N 190918 US10077266, Example 29::US9181249, 29::US9708313, 29 G-protein coupled receptor 6 Human 178000 US Patent 10.7270/Q2ZP4858 aid1795210 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190918 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190918&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159119 316936182 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494484 CC1N(CCc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(NCC(F)F)nc12)S(C)(=O)=O InChI=1S/C22H27F4N5O3S/c1-13-20-17(7-10-31(13)35(2,32)33)28-22(21(29-20)27-12-19(25)26)30-8-5-15(6-9-30)34-18-4-3-14(23)11-16(18)24/h3-4,11,13,15,19H,5-10,12H2,1-2H3,(H,27,29) WWPMMCYXCUAIQH-UHFFFAOYSA-N 190919 US10077266, Example 30::US9181249, 30::US9708313, 30 G-protein coupled receptor 6 Human 87000 US Patent 10.7270/Q2ZP4858 aid1795210 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190919 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190919&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159299 316936183 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494485 COCC(=O)N1CCc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(NCC(F)F)nc2C1C InChI=1S/C24H29F4N5O3/c1-14-22-18(7-10-33(14)21(34)13-35-2)30-24(23(31-22)29-12-20(27)28)32-8-5-16(6-9-32)36-19-4-3-15(25)11-17(19)26/h3-4,11,14,16,20H,5-10,12-13H2,1-2H3,(H,29,31) NIVHYTWKOHBPPG-UHFFFAOYSA-N 190920 US10077266, Example 31::US9181249, 31::US9708313, 31 G-protein coupled receptor 6 Human 208000 US Patent 10.7270/Q2ZP4858 aid1795210 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190920 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190920&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159333 316936184 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494486 CC1N(CCc2nc(NCC(F)F)c(nc12)N1CCC(CC1)Oc1ccc(F)cc1F)C(C)=O InChI=1S/C23H27F4N5O2/c1-13-21-18(7-10-32(13)14(2)33)29-22(28-12-20(26)27)23(30-21)31-8-5-16(6-9-31)34-19-4-3-15(24)11-17(19)25/h3-4,11,13,16,20H,5-10,12H2,1-2H3,(H,28,29) QJRXHWYPTZIIMW-UHFFFAOYSA-N 190921 US10077266, Example 32::US9181249, 32::US9708313, 32 G-protein coupled receptor 6 Human 76000 US Patent 10.7270/Q2ZP4858 aid1795210 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190921 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190921&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159172 316936185 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494487 CC1N(CCc2nc(NCC(F)F)c(nc12)N1CCC(CC1)Oc1ccc(F)cc1F)S(C)(=O)=O InChI=1S/C22H27F4N5O3S/c1-13-20-17(7-10-31(13)35(2,32)33)28-21(27-12-19(25)26)22(29-20)30-8-5-15(6-9-30)34-18-4-3-14(23)11-16(18)24/h3-4,11,13,15,19H,5-10,12H2,1-2H3,(H,27,28) WFSTYLJLIRNPTM-UHFFFAOYSA-N 190922 US10077266, Example 33::US9181249, 33::US9708313, 33 G-protein coupled receptor 6 Human 52000 US Patent 10.7270/Q2ZP4858 aid1795210 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190922 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190922&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159342 316936186 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494488 COCC(=O)N1CCc2nc(NCC(F)F)c(nc2C1C)N1CCC(CC1)Oc1ccc(F)cc1F InChI=1S/C24H29F4N5O3/c1-14-22-18(7-10-33(14)21(34)13-35-2)30-23(29-12-20(27)28)24(31-22)32-8-5-16(6-9-32)36-19-4-3-15(25)11-17(19)26/h3-4,11,14,16,20H,5-10,12-13H2,1-2H3,(H,29,30) NSRYHIBBVMQNQM-UHFFFAOYSA-N 190923 US10077266, Example 34::US9181249, 34::US9708313, 34 G-protein coupled receptor 6 Human 68000 US Patent 10.7270/Q2ZP4858 aid1795210 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190923 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190923&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159227 316936187 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494489 CC(C)Nc1nc2CCN(C(C)c2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(C)=O InChI=1S/C24H31F2N5O2/c1-14(2)27-23-24(29-22-15(3)31(16(4)32)12-9-20(22)28-23)30-10-7-18(8-11-30)33-21-6-5-17(25)13-19(21)26/h5-6,13-15,18H,7-12H2,1-4H3,(H,27,28) ARTKLIDEGICUHA-UHFFFAOYSA-N 190924 US10077266, Example 35::US9181249, 35::US9708313, 35 G-protein coupled receptor 6 Human 88000 US Patent 10.7270/Q2ZP4858 aid1795210 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190924 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190924&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159163 316936188 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494490 CC(C)Nc1nc2CCN(C(C)c2nc1N1CCC(CC1)Oc1ccc(F)cc1F)S(C)(=O)=O InChI=1S/C23H31F2N5O3S/c1-14(2)26-22-23(28-21-15(3)30(34(4,31)32)12-9-19(21)27-22)29-10-7-17(8-11-29)33-20-6-5-16(24)13-18(20)25/h5-6,13-15,17H,7-12H2,1-4H3,(H,26,27) MRTDGKOOBSBFRW-UHFFFAOYSA-N 190925 US10077266, Example 36::US9181249, 36::US9708313, 36 G-protein coupled receptor 6 Human 98000 US Patent 10.7270/Q2ZP4858 aid1795210 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190925 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190925&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159345 316936189 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494491 COCC(=O)N1CCc2nc(NC(C)C)c(nc2C1C)N1CCC(CC1)Oc1ccc(F)cc1F InChI=1S/C25H33F2N5O3/c1-15(2)28-24-25(30-23-16(3)32(22(33)14-34-4)12-9-20(23)29-24)31-10-7-18(8-11-31)35-21-6-5-17(26)13-19(21)27/h5-6,13,15-16,18H,7-12,14H2,1-4H3,(H,28,29) QDVKQXNZCPPZFC-UHFFFAOYSA-N 190926 US10077266, Example 37::US9181249, 37::US9708313, 37 G-protein coupled receptor 6 Human 91000 US Patent 10.7270/Q2ZP4858 aid1795210 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190926 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190926&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159181 316936190 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494492 CC1N(CCc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(NCC(F)F)nc12)C(=O)C1CC1 InChI=1S/C25H29F4N5O2/c1-14-22-19(8-11-34(14)25(35)15-2-3-15)31-24(23(32-22)30-13-21(28)29)33-9-6-17(7-10-33)36-20-5-4-16(26)12-18(20)27/h4-5,12,14-15,17,21H,2-3,6-11,13H2,1H3,(H,30,32) VJBZTVUXYAULIV-UHFFFAOYSA-N 190927 US10077266, Example 38::US9181249, 38::US9708313, 38 G-protein coupled receptor 6 Human 85000 US Patent 10.7270/Q2ZP4858 aid1795210 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190927 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190927&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159310 316936191 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494493 CC1N(CCc2nc(NCC(F)F)c(nc12)N1CCC(CC1)Oc1ccc(F)cc1F)C(=O)C1CC1 InChI=1S/C25H29F4N5O2/c1-14-22-19(8-11-34(14)25(35)15-2-3-15)31-23(30-13-21(28)29)24(32-22)33-9-6-17(7-10-33)36-20-5-4-16(26)12-18(20)27/h4-5,12,14-15,17,21H,2-3,6-11,13H2,1H3,(H,30,31) MTQHWKKEVIZVTJ-UHFFFAOYSA-N 190928 US10077266, Example 39::US9181249, 39::US9708313, 39 G-protein coupled receptor 6 Human 126000 US Patent 10.7270/Q2ZP4858 aid1795210 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190928 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190928&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159338 316936192 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494494 CC(C)Nc1nc2CCN(C(C)c2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(=O)C1CC1 InChI=1S/C26H33F2N5O2/c1-15(2)29-24-25(31-23-16(3)33(13-10-21(23)30-24)26(34)17-4-5-17)32-11-8-19(9-12-32)35-22-7-6-18(27)14-20(22)28/h6-7,14-17,19H,4-5,8-13H2,1-3H3,(H,29,30) JDZZALPMHQTADO-UHFFFAOYSA-N 190929 US10077266, Example 40::US9181249, 40::US9708313, 40 G-protein coupled receptor 6 Human 259000 US Patent 10.7270/Q2ZP4858 aid1795210 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190929 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190929&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159258 316936193 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494495 CC1N(CCc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(NCC(F)F)nc12)C(=O)C(F)F InChI=1S/C23H25F6N5O2/c1-12-19-16(6-9-34(12)23(35)20(28)29)31-22(21(32-19)30-11-18(26)27)33-7-4-14(5-8-33)36-17-3-2-13(24)10-15(17)25/h2-3,10,12,14,18,20H,4-9,11H2,1H3,(H,30,32) UJRTYZAYJRPNBW-UHFFFAOYSA-N 190930 US10077266, Example 41::US9181249, 41::US9708313, 41 G-protein coupled receptor 6 Human 212200 US Patent 10.7270/Q2ZP4858 aid1795209 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190930 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190930&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159298 316936194 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494496 CC1N(CCc2nc(NCC(F)F)c(nc12)N1CCC(CC1)Oc1ccc(F)cc1F)C(=O)C(F)F InChI=1S/C23H25F6N5O2/c1-12-19-16(6-9-34(12)23(35)20(28)29)31-21(30-11-18(26)27)22(32-19)33-7-4-14(5-8-33)36-17-3-2-13(24)10-15(17)25/h2-3,10,12,14,18,20H,4-9,11H2,1H3,(H,30,31) JTNXLHFGSOWSSM-UHFFFAOYSA-N 190931 US10077266, Example 42::US9181249, 42::US9708313, 42 G-protein coupled receptor 6 Human 193300 US Patent 10.7270/Q2ZP4858 aid1795209 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190931 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190931&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159363 316936195 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494497 CC(C)Nc1nc2CCN(C(C)c2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(=O)C(F)F InChI=1S/C24H29F4N5O2/c1-13(2)29-22-23(31-20-14(3)33(24(34)21(27)28)11-8-18(20)30-22)32-9-6-16(7-10-32)35-19-5-4-15(25)12-17(19)26/h4-5,12-14,16,21H,6-11H2,1-3H3,(H,29,30) QCTSOHZKORNTDB-UHFFFAOYSA-N 190932 US10077266, Example 43::US9181249, 43::US9708313, 43 G-protein coupled receptor 6 Human 115500 US Patent 10.7270/Q2ZP4858 aid1795209 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190932 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190932&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118180375 316936196 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494498 COc1ccc(OC2CCN(CC2)c2nc3C(C)N(CCc3nc2NC(C)C)C(C)=O)c(F)c1 InChI=1S/C25H34FN5O3/c1-15(2)27-24-25(29-23-16(3)31(17(4)32)13-10-21(23)28-24)30-11-8-18(9-12-30)34-22-7-6-19(33-5)14-20(22)26/h6-7,14-16,18H,8-13H2,1-5H3,(H,27,28) HYWHLUSGZSALCU-UHFFFAOYSA-N 261935 1-(3-(4-(2-fluoro-4-methoxyphenoxy)piperidin-1-yl)-2-(isopropylamino)-7,8-dihydropyrido[3,4-b]pyrazin-6(5H)-yl)ethanone::US9708313, 44 G-protein coupled receptor 6 Human 62500 US Patent 10.7270/Q2ZP4858 aid1795209 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=261935 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=261935&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118857196 376223773 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494499 COc1ccc(OC2CCN(CC2)c2nc3CCN(Cc3nc2NC(C)C)C(C)=O)c(F)c1 InChI=1S/C24H32FN5O3/c1-15(2)26-23-24(28-20-9-12-30(16(3)31)14-21(20)27-23)29-10-7-17(8-11-29)33-22-6-5-18(32-4)13-19(22)25/h5-6,13,15,17H,7-12,14H2,1-4H3,(H,26,27) VEBMYLUUDSKYQF-UHFFFAOYSA-N 190934 US10077266, Example 45::US9181249, 45::US9708313, 45 G-protein coupled receptor 6 Human 74100 US Patent 10.7270/Q2ZP4858 aid1795209 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190934 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190934&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159385 316936198 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494500 COc1ccc(OC2CCN(CC2)c2nc3CCN(Cc3nc2NC(C)C)C(=O)N(C)C)c(F)c1 InChI=1S/C25H35FN6O3/c1-16(2)27-23-24(29-20-10-13-32(15-21(20)28-23)25(33)30(3)4)31-11-8-17(9-12-31)35-22-7-6-18(34-5)14-19(22)26/h6-7,14,16-17H,8-13,15H2,1-5H3,(H,27,28) HARGAPZWEJDNCT-UHFFFAOYSA-N 190935 US10077266, Example 46::US9181249, 46::US9708313, 46 G-protein coupled receptor 6 Human 35000 US Patent 10.7270/Q2ZP4858 aid1795210 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190935 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190935&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159393 316936199 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494501 CC(C)Nc1nc2CN(CCc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(C)=O InChI=1S/C23H29F2N5O2/c1-14(2)26-22-23(28-19-8-11-30(15(3)31)13-20(19)27-22)29-9-6-17(7-10-29)32-21-5-4-16(24)12-18(21)25/h4-5,12,14,17H,6-11,13H2,1-3H3,(H,26,27) FSUXDPIOBQLEKO-UHFFFAOYSA-N 190936 US10077266, Example 141::US9181249, 141::US9181249, 47::US9708313, 141 G-protein coupled receptor 6 Human 24600 US Patent 10.7270/Q2ZP4858 aid1795209 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190936 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190936&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 91810771 316936200 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494502 CN(C)C(=O)N1CCc2nc(NCC(F)F)c(nc2C1)N1CCC(CC1)Oc1ccc(F)cc1F InChI=1S/C23H28F4N6O2/c1-31(2)23(34)33-10-7-17-18(13-33)30-22(21(29-17)28-12-20(26)27)32-8-5-15(6-9-32)35-19-4-3-14(24)11-16(19)25/h3-4,11,15,20H,5-10,12-13H2,1-2H3,(H,28,29) PFHQZVCJRTUASF-UHFFFAOYSA-N 190937 US10077266, Example 49::US9181249, 49::US9708313, 49 G-protein coupled receptor 6 Human 9100 US Patent 10.7270/Q2ZP4858 aid1795210 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190937 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190937&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159362 316936201 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494503 COCC(=O)N1CCc2nc(NCC(F)F)c(nc2C1)N1CCC(CC1)Oc1ccc(F)cc1F InChI=1S/C23H27F4N5O3/c1-34-13-21(33)32-9-6-17-18(12-32)30-23(22(29-17)28-11-20(26)27)31-7-4-15(5-8-31)35-19-3-2-14(24)10-16(19)25/h2-3,10,15,20H,4-9,11-13H2,1H3,(H,28,29) GDLRFXBQKYAJKF-UHFFFAOYSA-N 190938 US10077266, Example 50::US9181249, 50::US9708313, 50 G-protein coupled receptor 6 Human 79500 US Patent 10.7270/Q2ZP4858 aid1795209 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190938 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190938&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159408 316936202 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494504 CO[C@H](C)C(=O)N1CCc2nc(NCC(F)F)c(nc2C1)N1CCC(CC1)Oc1ccc(F)cc1F InChI=1S/C24H29F4N5O3/c1-14(35-2)24(34)33-10-7-18-19(13-33)31-23(22(30-18)29-12-21(27)28)32-8-5-16(6-9-32)36-20-4-3-15(25)11-17(20)26/h3-4,11,14,16,21H,5-10,12-13H2,1-2H3,(H,29,30)/t14-/m1/s1 FQWWKVZBYLUHMI-CQSZACIVSA-N 190939 US10077266, Example 51::US9181249, 51::US9708313, 51 G-protein coupled receptor 6 Human 6600 US Patent 10.7270/Q2ZP4858 aid1795210 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190939 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190939&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159182 316936203 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494505 CC(C)Nc1nc2C(C)N(CCc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(C)=O InChI=1S/C24H31F2N5O2/c1-14(2)27-23-24(28-20-9-12-31(16(4)32)15(3)22(20)29-23)30-10-7-18(8-11-30)33-21-6-5-17(25)13-19(21)26/h5-6,13-15,18H,7-12H2,1-4H3,(H,27,29) FMOCPXCISTZQSC-UHFFFAOYSA-N 190940 US10077266, Example 52::US9181249, 52::US9708313, 52 G-protein coupled receptor 6 Human 73200 US Patent 10.7270/Q2ZP4858 aid1795209 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190940 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190940&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159253 316936204 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494506 CC(C)Nc1nc2C(C)N(CCc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(=O)C(F)F InChI=1S/C24H29F4N5O2/c1-13(2)29-22-23(30-18-8-11-33(24(34)21(27)28)14(3)20(18)31-22)32-9-6-16(7-10-32)35-19-5-4-15(25)12-17(19)26/h4-5,12-14,16,21H,6-11H2,1-3H3,(H,29,31) XIOKGNQYBGJUAK-UHFFFAOYSA-N 190941 US10077266, Example 53::US9181249, 53::US9708313, 53 G-protein coupled receptor 6 Human 95000 US Patent 10.7270/Q2ZP4858 aid1795209 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190941 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190941&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159325 316936205 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494507 CC(C)Nc1nc2C(C)N(CCc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)S(C)(=O)=O InChI=1S/C23H31F2N5O3S/c1-14(2)26-22-23(27-19-9-12-30(34(4,31)32)15(3)21(19)28-22)29-10-7-17(8-11-29)33-20-6-5-16(24)13-18(20)25/h5-6,13-15,17H,7-12H2,1-4H3,(H,26,28) VEJYSDDQSCHEPV-UHFFFAOYSA-N 190942 US10077266, Example 54::US9181249, 54::US9708313, 54 G-protein coupled receptor 6 Human 59300 US Patent 10.7270/Q2ZP4858 aid1795209 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190942 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190942&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159355 316936206 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494508 CC(C)Nc1nc2C(C)N(CCc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(=O)N(C)C InChI=1S/C25H34F2N6O2/c1-15(2)28-23-24(29-20-10-13-33(25(34)31(4)5)16(3)22(20)30-23)32-11-8-18(9-12-32)35-21-7-6-17(26)14-19(21)27/h6-7,14-16,18H,8-13H2,1-5H3,(H,28,30) NNRCOKXZVAPOJH-UHFFFAOYSA-N 190943 US10077266, Example 55::US9181249, 55::US9708313, 55 G-protein coupled receptor 6 Human 109600 US Patent 10.7270/Q2ZP4858 aid1795209 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190943 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190943&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159383 316936207 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494509 CC(C)Nc1nc2CCN(C(C)c2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(=O)N(C)C InChI=1S/C25H34F2N6O2/c1-15(2)28-23-24(30-22-16(3)33(25(34)31(4)5)13-10-20(22)29-23)32-11-8-18(9-12-32)35-21-7-6-17(26)14-19(21)27/h6-7,14-16,18H,8-13H2,1-5H3,(H,28,29) PZGMGSSLOFKXMB-UHFFFAOYSA-N 190944 US10077266, Example 56::US9181249, 56::US9708313, 56 G-protein coupled receptor 6 Human 179400 US Patent 10.7270/Q2ZP4858 aid1795209 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190944 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190944&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159380 316936208 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494510 CC1N(CCc2nc(NCC(F)F)c(nc12)N1CCC(CC1)Oc1ccc(F)cc1F)C(=O)N(C)C InChI=1S/C24H30F4N6O2/c1-14-21-18(8-11-34(14)24(35)32(2)3)30-22(29-13-20(27)28)23(31-21)33-9-6-16(7-10-33)36-19-5-4-15(25)12-17(19)26/h4-5,12,14,16,20H,6-11,13H2,1-3H3,(H,29,30) WQBBZAUSIBHYSV-UHFFFAOYSA-N 190945 US10077266, Example 57::US9181249, 57::US9708313, 57 G-protein coupled receptor 6 Human 93500 US Patent 10.7270/Q2ZP4858 aid1795209 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190945 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190945&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159122 316936209 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494511 COc1ccc(OC2CCN(CC2)c2nc3CN(C)CCc3nc2NC(C)C)c(F)c1 InChI=1S/C23H32FN5O2/c1-15(2)25-22-23(27-20-14-28(3)10-9-19(20)26-22)29-11-7-16(8-12-29)31-21-6-5-17(30-4)13-18(21)24/h5-6,13,15-16H,7-12,14H2,1-4H3,(H,25,26) LPDQCOZZDLFEPF-UHFFFAOYSA-N 190946 US10077266, Example 58::US9181249, 58::US9708313, 58 G-protein coupled receptor 6 Human 26600 US Patent 10.7270/Q2ZP4858 aid1795210 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190946 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190946&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159341 316936210 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494512 CC(=O)N1CCc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(NCC(F)F)nc2C1 InChI=1S/C22H25F4N5O2/c1-13(32)31-9-6-17-18(12-31)28-21(27-11-20(25)26)22(29-17)30-7-4-15(5-8-30)33-19-3-2-14(23)10-16(19)24/h2-3,10,15,20H,4-9,11-12H2,1H3,(H,27,28) RXQZHPDNUHUQAQ-UHFFFAOYSA-N 190947 US10077266, Example 59::US9181249, 59::US9708313, 59 G-protein coupled receptor 6 Human 49700 US Patent 10.7270/Q2ZP4858 aid1795209 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190947 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190947&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159289 316936211 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494513 CN1CCc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(NCC(F)F)nc2C1 InChI=1S/C21H25F4N5O/c1-29-7-6-16-17(12-29)27-20(26-11-19(24)25)21(28-16)30-8-4-14(5-9-30)31-18-3-2-13(22)10-15(18)23/h2-3,10,14,19H,4-9,11-12H2,1H3,(H,26,27) OPFNFNXTVSGTOP-UHFFFAOYSA-N 190948 US10077266, Example 60::US9181249, 60::US9708313, 60 G-protein coupled receptor 6 Human >1000000 US Patent 10.7270/Q2ZP4858 aid1795209 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190948 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190948&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159195 316936212 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494514 COC(=O)N1CCc2nc(NC(C)C)c(nc2C1)N1CCC(CC1)Oc1ccc(F)cc1F InChI=1S/C23H29F2N5O3/c1-14(2)26-21-22(28-19-13-30(23(31)32-3)11-8-18(19)27-21)29-9-6-16(7-10-29)33-20-5-4-15(24)12-17(20)25/h4-5,12,14,16H,6-11,13H2,1-3H3,(H,26,27) SZOSUMSBFSLIFI-UHFFFAOYSA-N 190949 US10077266, Example 61::US9181249, 61::US9708313, 61 G-protein coupled receptor 6 Human 131700 US Patent 10.7270/Q2ZP4858 aid1795209 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190949 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190949&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159218 316936213 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494515 CC(C)Nc1nc2CCN(CCF)Cc2nc1N1CCC(CC1)Oc1ccc(F)cc1F InChI=1S/C23H30F3N5O/c1-15(2)27-22-23(29-20-14-30(12-8-24)9-7-19(20)28-22)31-10-5-17(6-11-31)32-21-4-3-16(25)13-18(21)26/h3-4,13,15,17H,5-12,14H2,1-2H3,(H,27,28) YWDLIXCPOBESJK-UHFFFAOYSA-N 190950 US10077266, Example 62::US9181249, 62::US9708313, 62 G-protein coupled receptor 6 Human 69200 US Patent 10.7270/Q2ZP4858 aid1795209 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190950 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190950&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159173 316936214 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494516 CC(C)Nc1nc2CN(CCc2nc1N1CCC(CC1)[C@@H](F)c1ccc(F)cc1F)C(C)=O InChI=1S/C24H30F3N5O/c1-14(2)28-23-24(30-20-8-11-32(15(3)33)13-21(20)29-23)31-9-6-16(7-10-31)22(27)18-5-4-17(25)12-19(18)26/h4-5,12,14,16,22H,6-11,13H2,1-3H3,(H,28,29)/t22-/m1/s1 TZLIJUSGPVQVEO-JOCHJYFZSA-N 261953 (R)-1-(2-(4-((2,4-difluorophenyl)fluoromethyl)piperidin-1-yl)-3-(isopropylamino)-7,8-dihydropyrido[3,4-b]pyrazin-6(5H)-yl)ethan-1-one::US10077266, Example 63::US9708313, 63 G-protein coupled receptor 6 Human 37800 US Patent 10.7270/Q2ZP4858 aid1795209 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=261953 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=261953&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159318 376223791 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494517 COc1ccc(OC2CCN(CC2)c2nc3CN(C)CCc3nc2NC2CC2)c(F)c1 InChI=1S/C23H30FN5O2/c1-28-10-9-19-20(14-28)27-23(22(26-19)25-15-3-4-15)29-11-7-16(8-12-29)31-21-6-5-17(30-2)13-18(21)24/h5-6,13,15-16H,3-4,7-12,14H2,1-2H3,(H,25,26) WWWODUMJPXCYHV-UHFFFAOYSA-N 190953 US10077266, Example 66::US9181249, 66::US9708313, 66 G-protein coupled receptor 6 Human 145000 US Patent 10.7270/Q2ZP4858 aid1795210 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190953 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190953&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159306 316936216 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494518 CN1CCc2nc(NC3CC3)c(nc2C1)N1CCC(CC1)C(F)c1ccc(F)cc1F InChI=1S/C23H28F3N5/c1-30-9-8-19-20(13-30)29-23(22(28-19)27-16-3-4-16)31-10-6-14(7-11-31)21(26)17-5-2-15(24)12-18(17)25/h2,5,12,14,16,21H,3-4,6-11,13H2,1H3,(H,27,28) GZJWUTGKWXOMFU-UHFFFAOYSA-N 190954 US10077266, Example 67::US9181249, 67::US9708313, 67 G-protein coupled receptor 6 Human 9400 US Patent 10.7270/Q2ZP4858 aid1795210 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190954 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190954&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159174 316936217 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494519 CN1CCc2nc(NC3CC3)c(nc2C1)N1CCC(CC1)[C@H](F)c1ccc(F)cc1F InChI=1S/C23H28F3N5/c1-30-9-8-19-20(13-30)29-23(22(28-19)27-16-3-4-16)31-10-6-14(7-11-31)21(26)17-5-2-15(24)12-18(17)25/h2,5,12,14,16,21H,3-4,6-11,13H2,1H3,(H,27,28)/t21-/m0/s1 GZJWUTGKWXOMFU-NRFANRHFSA-N 190955 US10077266, Example 68::US9181249, 68::US9708313, 68 G-protein coupled receptor 6 Human 15200 US Patent 10.7270/Q2ZP4858 aid1795210 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190955 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190955&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159243 316936218 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494520 CN1CCc2nc(NC3CC3)c(nc2C1)N1CCC(CC1)[C@@H](F)c1ccc(F)cc1F InChI=1S/C23H28F3N5/c1-30-9-8-19-20(13-30)29-23(22(28-19)27-16-3-4-16)31-10-6-14(7-11-31)21(26)17-5-2-15(24)12-18(17)25/h2,5,12,14,16,21H,3-4,6-11,13H2,1H3,(H,27,28)/t21-/m1/s1 GZJWUTGKWXOMFU-OAQYLSRUSA-N 190956 US10077266, Example 69::US9181249, 69::US9708313, 69 G-protein coupled receptor 6 Human 26500 US Patent 10.7270/Q2ZP4858 aid1795210 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190956 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190956&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159251 316936219 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494521 CC(C)Nc1nc2CCN(C)Cc2nc1N1CCC(CC1)C(F)c1ccc(F)cc1F InChI=1S/C23H30F3N5/c1-14(2)27-22-23(29-20-13-30(3)9-8-19(20)28-22)31-10-6-15(7-11-31)21(26)17-5-4-16(24)12-18(17)25/h4-5,12,14-15,21H,6-11,13H2,1-3H3,(H,27,28) OLJCDRLYVMFDIN-UHFFFAOYSA-N 190957 US10077266, Example 70::US9181249, 70::US9708313, 70 G-protein coupled receptor 6 Human 17100 US Patent 10.7270/Q2ZP4858 aid1795209 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190957 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190957&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159372 316936220 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494522 CC(C)Nc1nc2CCN(Cc2nc1N1CCC(CC1)C(F)c1ccc(F)cc1F)C(C)=O InChI=1S/C24H30F3N5O/c1-14(2)28-23-24(30-21-13-32(15(3)33)11-8-20(21)29-23)31-9-6-16(7-10-31)22(27)18-5-4-17(25)12-19(18)26/h4-5,12,14,16,22H,6-11,13H2,1-3H3,(H,28,29) HUXMBOZHWUYKBH-UHFFFAOYSA-N 190958 US10077266, Example 71::US9181249, 71::US9708313, 71 G-protein coupled receptor 6 Human 8500 US Patent 10.7270/Q2ZP4858 aid1795210 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190958 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190958&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159272 316936221 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494523 CC(C)Nc1nc2CCN(Cc2nc1N1CCC(CC1)C(F)c1ccc(F)cc1F)C(=O)N(C)C InChI=1S/C25H33F3N6O/c1-15(2)29-23-24(31-21-14-34(25(35)32(3)4)12-9-20(21)30-23)33-10-7-16(8-11-33)22(28)18-6-5-17(26)13-19(18)27/h5-6,13,15-16,22H,7-12,14H2,1-4H3,(H,29,30) BJKRRQIZQPWPHY-UHFFFAOYSA-N 190959 US10077266, Example 72::US9181249, 72::US9708313, 72 G-protein coupled receptor 6 Human 23700 US Patent 10.7270/Q2ZP4858 aid1795210 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190959 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190959&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159294 316936222 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494524 COc1ccc(OC2CCN(CC2)c2nc3CN(CCc3nc2NC(C)C)C(=O)N(C)C)c(F)c1 InChI=1S/C25H35FN6O3/c1-16(2)27-23-24(29-21-15-32(25(33)30(3)4)13-10-20(21)28-23)31-11-8-17(9-12-31)35-22-7-6-18(34-5)14-19(22)26/h6-7,14,16-17H,8-13,15H2,1-5H3,(H,27,28) IRGNVXRGFACSOX-UHFFFAOYSA-N 190960 US10077266, Example 73::US9181249, 73::US9708313, 73 G-protein coupled receptor 6 Human 16600 US Patent 10.7270/Q2ZP4858 aid1795210 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190960 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190960&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159196 316936223 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494525 COc1ccc(OC2CCN(CC2)c2nc3CCN(C)Cc3nc2NC(C)C)c(F)c1 InChI=1S/C23H32FN5O2/c1-15(2)25-22-23(27-19-9-10-28(3)14-20(19)26-22)29-11-7-16(8-12-29)31-21-6-5-17(30-4)13-18(21)24/h5-6,13,15-16H,7-12,14H2,1-4H3,(H,25,26) DFMRQAQETRMYOT-UHFFFAOYSA-N 190961 US10077266, Example 74::US9181249, 74::US9708313, 74 G-protein coupled receptor 6 Human 140200 US Patent 10.7270/Q2ZP4858 aid1795209 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190961 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190961&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159150 316936224 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494526 CC(C)Nc1nc2CN(C)CCc2nc1N1CCC(CC1)C(F)c1ccc(F)cc1F InChI=1S/C23H30F3N5/c1-14(2)27-22-23(29-19-8-9-30(3)13-20(19)28-22)31-10-6-15(7-11-31)21(26)17-5-4-16(24)12-18(17)25/h4-5,12,14-15,21H,6-11,13H2,1-3H3,(H,27,28) LNHWNOWSQBYDGD-UHFFFAOYSA-N 190962 US10077266, Example 75::US9181249, 75::US9708313, 75 G-protein coupled receptor 6 Human 30300 US Patent 10.7270/Q2ZP4858 aid1795209 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190962 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190962&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159344 316936225 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494527 CC(C)Nc1nc2CN(CCc2nc1N1CCC(CC1)C(F)c1ccc(F)cc1F)C(C)=O InChI=1S/C24H30F3N5O/c1-14(2)28-23-24(30-20-8-11-32(15(3)33)13-21(20)29-23)31-9-6-16(7-10-31)22(27)18-5-4-17(25)12-19(18)26/h4-5,12,14,16,22H,6-11,13H2,1-3H3,(H,28,29) TZLIJUSGPVQVEO-UHFFFAOYSA-N 190963 US10077266, Example 76::US9181249, 76::US9708313, 76 G-protein coupled receptor 6 Human 13400 US Patent 10.7270/Q2ZP4858 aid1795210 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190963 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190963&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159216 316936226 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494528 CC(C)Nc1nc2CN(CCc2nc1N1CCC(CC1)C(F)c1ccc(F)cc1F)C(=O)N(C)C InChI=1S/C25H33F3N6O/c1-15(2)29-23-24(31-20-9-12-34(14-21(20)30-23)25(35)32(3)4)33-10-7-16(8-11-33)22(28)18-6-5-17(26)13-19(18)27/h5-6,13,15-16,22H,7-12,14H2,1-4H3,(H,29,30) WEWPKQJONYAZFF-UHFFFAOYSA-N 190964 US10077266, Example 77::US9181249, 77::US9708313, 77 G-protein coupled receptor 6 Human 19700 US Patent 10.7270/Q2ZP4858 aid1795210 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190964 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190964&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159153 316936227 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494529 CC(C)Nc1nc2CCN(C)Cc2nc1N1CCC(CC1)C(=O)c1cc(Cl)ccc1F InChI=1S/C23H29ClFN5O/c1-14(2)26-22-23(28-20-13-29(3)9-8-19(20)27-22)30-10-6-15(7-11-30)21(31)17-12-16(24)4-5-18(17)25/h4-5,12,14-15H,6-11,13H2,1-3H3,(H,26,27) RKEKPUMPMWDOCH-UHFFFAOYSA-N 190965 US10077266, Example 78::US9181249, 78::US9708313, 78 G-protein coupled receptor 6 Human 8800 US Patent 10.7270/Q2ZP4858 aid1795210 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190965 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190965&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159276 316936228 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494530 CC(C)Nc1nc2CCN(Cc2nc1N1CCC(CC1)C(=O)c1cc(Cl)ccc1F)C(C)=O InChI=1S/C24H29ClFN5O2/c1-14(2)27-23-24(29-21-13-31(15(3)32)11-8-20(21)28-23)30-9-6-16(7-10-30)22(33)18-12-17(25)4-5-19(18)26/h4-5,12,14,16H,6-11,13H2,1-3H3,(H,27,28) OAAWXLYGSCRDKI-UHFFFAOYSA-N 190966 US10077266, Example 79::US9181249, 79::US9708313, 79 G-protein coupled receptor 6 Human 9800 US Patent 10.7270/Q2ZP4858 aid1795210 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190966 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190966&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159151 316936229 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494531 CC(C)Nc1nc2CCN(Cc2nc1N1CCC(CC1)C(=O)c1cc(Cl)ccc1F)C(=O)N(C)C InChI=1S/C25H32ClFN6O2/c1-15(2)28-23-24(30-21-14-33(25(35)31(3)4)12-9-20(21)29-23)32-10-7-16(8-11-32)22(34)18-13-17(26)5-6-19(18)27/h5-6,13,15-16H,7-12,14H2,1-4H3,(H,28,29) JOAGWBROEFGAGV-UHFFFAOYSA-N 190967 US10077266, Example 80::US9181249, 80::US9708313, 80 G-protein coupled receptor 6 Human 24900 US Patent 10.7270/Q2ZP4858 aid1795210 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190967 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190967&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159180 316936230 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494532 CC(C)Nc1nc2CCN(C)Cc2nc1N1CCC(CC1)Oc1ccc(F)cc1F InChI=1S/C22H29F2N5O/c1-14(2)25-21-22(27-19-13-28(3)9-8-18(19)26-21)29-10-6-16(7-11-29)30-20-5-4-15(23)12-17(20)24/h4-5,12,14,16H,6-11,13H2,1-3H3,(H,25,26) OLWFSHRVTXHOAB-UHFFFAOYSA-N 190968 US10077266, Example 81::US9181249, 81::US9708313, 81 G-protein coupled receptor 6 Human 59500 US Patent 10.7270/Q2ZP4858 aid1795209 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190968 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190968&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159352 316936231 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494533 CC(C)Nc1nc2CCN(Cc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(C)=O InChI=1S/C23H29F2N5O2/c1-14(2)26-22-23(28-20-13-30(15(3)31)11-8-19(20)27-22)29-9-6-17(7-10-29)32-21-5-4-16(24)12-18(21)25/h4-5,12,14,17H,6-11,13H2,1-3H3,(H,26,27) GONMCTNGCPLRCY-UHFFFAOYSA-N 190969 US10077266, Example 156::US9181249, 156::US9181249, 82::US9708313, 156 G-protein coupled receptor 6 Human 73700 US Patent 10.7270/Q2ZP4858 aid1795209 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190969 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190969&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159235 316936232 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494534 CC(C)Nc1nc2CCN(Cc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(=O)N(C)C InChI=1S/C24H32F2N6O2/c1-15(2)27-22-23(29-20-14-32(24(33)30(3)4)12-9-19(20)28-22)31-10-7-17(8-11-31)34-21-6-5-16(25)13-18(21)26/h5-6,13,15,17H,7-12,14H2,1-4H3,(H,27,28) WBUGZKCCSZPEPZ-UHFFFAOYSA-N 261971 3-(4-(2,4-difluorophenoxy)piperidin-1-yl)-2-(isopropylamino)-N,N-dimethyl-7,8-dihydropyrido[3,4-b]pyrazine-6(5H)-carboxamide::US10077266, Example 83::US9708313, 83 G-protein coupled receptor 6 Human 13800 US Patent 10.7270/Q2ZP4858 aid1795210 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=261971 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=261971&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159332 376223809 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494535 CC(C)Nc1nc2CN(C)CCc2nc1N1CCC(CC1)Oc1ccc(F)cc1F InChI=1S/C22H29F2N5O/c1-14(2)25-21-22(27-18-8-9-28(3)13-19(18)26-21)29-10-6-16(7-11-29)30-20-5-4-15(23)12-17(20)24/h4-5,12,14,16H,6-11,13H2,1-3H3,(H,25,26) WVNJJQCGMGXTTA-UHFFFAOYSA-N 190971 US10077266, Example 84::US9181249, 84::US9708313, 84 G-protein coupled receptor 6 Human 90100 US Patent 10.7270/Q2ZP4858 aid1795209 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190971 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190971&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159398 316936234 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494536 CC(C)Nc1nc2CN(CCc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(=O)N(C)C InChI=1S/C24H32F2N6O2/c1-15(2)27-22-23(29-19-9-12-32(14-20(19)28-22)24(33)30(3)4)31-10-7-17(8-11-31)34-21-6-5-16(25)13-18(21)26/h5-6,13,15,17H,7-12,14H2,1-4H3,(H,27,28) FEEMZVMCVWMCAB-UHFFFAOYSA-N 190972 US10077266, Example 85::US9181249, 85::US9708313, 85 G-protein coupled receptor 6 Human 10400 US Patent 10.7270/Q2ZP4858 aid1795210 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190972 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190972&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159250 316936235 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494537 CC(C)Nc1nc2CN(C)CCc2nc1N1CCC(CC1)C(=O)c1cc(Cl)ccc1F InChI=1S/C23H29ClFN5O/c1-14(2)26-22-23(28-19-8-9-29(3)13-20(19)27-22)30-10-6-15(7-11-30)21(31)17-12-16(24)4-5-18(17)25/h4-5,12,14-15H,6-11,13H2,1-3H3,(H,26,27) NNCMDNRHJDTQBI-UHFFFAOYSA-N 190973 US9181249, 86::US9708313, 86 G-protein coupled receptor 6 Human 13700 US Patent 10.7270/Q2ZP4858 aid1795210 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190973 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190973&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159326 316936236 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494538 CC(C)Nc1nc2CN(CCc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(C)=O InChI=1S/C23H29F2N5O2/c1-14(2)26-22-23(28-19-8-11-30(15(3)31)13-20(19)27-22)29-9-6-17(7-10-29)32-21-5-4-16(24)12-18(21)25/h4-5,12,14,17H,6-11,13H2,1-3H3,(H,26,27) FSUXDPIOBQLEKO-UHFFFAOYSA-N 190936 US10077266, Example 141::US9181249, 141::US9181249, 47::US9708313, 141 G-protein coupled receptor 6 Human 13800 US Patent 10.7270/Q2ZP4858 aid1795210 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190936 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190936&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 91810771 316936200 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494539 CC(C)Nc1nc2CN(CCc2nc1N1CCC(CC1)C(=O)c1cc(Cl)ccc1F)C(=O)N(C)C InChI=1S/C25H32ClFN6O2/c1-15(2)28-23-24(30-20-9-12-33(14-21(20)29-23)25(35)31(3)4)32-10-7-16(8-11-32)22(34)18-13-17(26)5-6-19(18)27/h5-6,13,15-16H,7-12,14H2,1-4H3,(H,28,29) LACYCIZBHVBIAT-UHFFFAOYSA-N 190975 US9181249, 88::US9708313, 88 G-protein coupled receptor 6 Human 32700 US Patent 10.7270/Q2ZP4858 aid1795210 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190975 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190975&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159213 316936238 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494540 CC(=O)N1CCc2nc(NCC(F)F)c(nc2C1)N1CCC(CC1)Oc1ccc(F)cc1F InChI=1S/C22H25F4N5O2/c1-13(32)31-9-6-17-18(12-31)29-22(21(28-17)27-11-20(25)26)30-7-4-15(5-8-30)33-19-3-2-14(23)10-16(19)24/h2-3,10,15,20H,4-9,11-12H2,1H3,(H,27,28) GKYXBAFONJCMAT-UHFFFAOYSA-N 190978 US10077266, Example 91::US9181249, 91::US9708313, 91 G-protein coupled receptor 6 Human 11500 US Patent 10.7270/Q2ZP4858 aid1795210 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190978 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190978&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159394 316936239 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494541 COc1ccc(OC2CCN(CC2)c2nc3CN(CCc3nc2NC2CCC2)C(C)=O)c(F)c1 InChI=1S/C25H32FN5O3/c1-16(32)31-13-10-21-22(15-31)29-25(24(28-21)27-17-4-3-5-17)30-11-8-18(9-12-30)34-23-7-6-19(33-2)14-20(23)26/h6-7,14,17-18H,3-5,8-13,15H2,1-2H3,(H,27,28) LYHKILMWCNIPHU-UHFFFAOYSA-N 190979 US10077266, Example 92::US9181249, 92::US9708313, 92 G-protein coupled receptor 6 Human 12000 US Patent 10.7270/Q2ZP4858 aid1795210 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190979 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190979&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159402 316936240 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494542 COc1ccc(OC2CCN(CC2)c2nc3CN(CCc3nc2NC2CCC2)C(=O)N(C)C)c(F)c1 InChI=1S/C26H35FN6O3/c1-31(2)26(34)33-14-11-21-22(16-33)30-25(24(29-21)28-17-5-4-6-17)32-12-9-18(10-13-32)36-23-8-7-19(35-3)15-20(23)27/h7-8,15,17-18H,4-6,9-14,16H2,1-3H3,(H,28,29) MBEGIEVLFABLED-UHFFFAOYSA-N 190980 US10077266, Example 93::US9181249, 93::US9708313, 93 G-protein coupled receptor 6 Human 13800 US Patent 10.7270/Q2ZP4858 aid1795210 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190980 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190980&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159378 316936241 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494543 COc1ccc(OC2CCN(CC2)c2nc3CCN(Cc3nc2NC2CCC2)C(C)=O)c(F)c1 InChI=1S/C25H32FN5O3/c1-16(32)31-13-10-21-22(15-31)28-24(27-17-4-3-5-17)25(29-21)30-11-8-18(9-12-30)34-23-7-6-19(33-2)14-20(23)26/h6-7,14,17-18H,3-5,8-13,15H2,1-2H3,(H,27,28) FWBUWGUMMSYEGD-UHFFFAOYSA-N 190981 US10077266, Example 94::US9181249, 94::US9708313, 94 G-protein coupled receptor 6 Human 19900 US Patent 10.7270/Q2ZP4858 aid1795210 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190981 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190981&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159377 316936242 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494544 COc1ccc(OC2CCN(CC2)c2nc3CCN(Cc3nc2NC2CCC2)C(=O)N(C)C)c(F)c1 InChI=1S/C26H35FN6O3/c1-31(2)26(34)33-14-11-21-22(16-33)29-24(28-17-5-4-6-17)25(30-21)32-12-9-18(10-13-32)36-23-8-7-19(35-3)15-20(23)27/h7-8,15,17-18H,4-6,9-14,16H2,1-3H3,(H,28,29) GENCHWDTLHDGDV-UHFFFAOYSA-N 190982 US10077266, Example 95::US9181249, 95::US9708313, 95 G-protein coupled receptor 6 Human 32500 US Patent 10.7270/Q2ZP4858 aid1795210 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190982 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190982&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159324 316936243 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494545 CN(C)C(=O)N1CCc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(NCC(F)F)nc2C1 InChI=1S/C23H28F4N6O2/c1-31(2)23(34)33-10-7-17-18(13-33)29-21(28-12-20(26)27)22(30-17)32-8-5-15(6-9-32)35-19-4-3-14(24)11-16(19)25/h3-4,11,15,20H,5-10,12-13H2,1-2H3,(H,28,29) KCNUCXSMWFOXEY-UHFFFAOYSA-N 190983 US10077266, Example 96::US9181249, 96::US9708313, 96 G-protein coupled receptor 6 Human 26900 US Patent 10.7270/Q2ZP4858 aid1795210 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190983 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190983&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159322 316936244 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494546 CS(=O)(=O)N1CCc2nc(NCC(F)F)c(nc2C1)N1CCC(CC1)Oc1ccc(F)cc1F InChI=1S/C21H25F4N5O3S/c1-34(31,32)30-9-6-16-17(12-30)28-21(20(27-16)26-11-19(24)25)29-7-4-14(5-8-29)33-18-3-2-13(22)10-15(18)23/h2-3,10,14,19H,4-9,11-12H2,1H3,(H,26,27) OGDJAPZFQNICMB-UHFFFAOYSA-N 190984 US10077266, Example 97::US9181249, 97::US9708313, 97 G-protein coupled receptor 6 Human 163000 US Patent 10.7270/Q2ZP4858 aid1795209 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190984 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190984&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159305 316936245 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494547 FC(F)CNc1nc2CCN(Cc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(=O)C(F)F InChI=1S/C22H23F6N5O2/c23-12-1-2-17(14(24)9-12)35-13-3-6-32(7-4-13)21-20(29-10-18(25)26)30-15-5-8-33(11-16(15)31-21)22(34)19(27)28/h1-2,9,13,18-19H,3-8,10-11H2,(H,29,30) NCBHSJWWCRASPE-UHFFFAOYSA-N 190985 US10077266, Example 98::US9181249, 98::US9708313, 98 G-protein coupled receptor 6 Human 110600 US Patent 10.7270/Q2ZP4858 aid1795209 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190985 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190985&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159287 316936246 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494548 CO[C@@H](C)C(=O)N1CCc2nc(NCC(F)F)c(nc2C1)N1CCC(CC1)Oc1ccc(F)cc1F InChI=1S/C24H29F4N5O3/c1-14(35-2)24(34)33-10-7-18-19(13-33)31-23(22(30-18)29-12-21(27)28)32-8-5-16(6-9-32)36-20-4-3-15(25)11-17(20)26/h3-4,11,14,16,21H,5-10,12-13H2,1-2H3,(H,29,30)/t14-/m0/s1 FQWWKVZBYLUHMI-AWEZNQCLSA-N 190986 US10077266, Example 99::US9181249, 99::US9708313, 99 G-protein coupled receptor 6 Human 8300 US Patent 10.7270/Q2ZP4858 aid1795210 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190986 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190986&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159176 316936247 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494549 CS(=O)(=O)N1CCc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(NCC(F)F)nc2C1 InChI=1S/C21H25F4N5O3S/c1-34(31,32)30-9-6-16-17(12-30)27-20(26-11-19(24)25)21(28-16)29-7-4-14(5-8-29)33-18-3-2-13(22)10-15(18)23/h2-3,10,14,19H,4-9,11-12H2,1H3,(H,26,27) SRXPWKHLALLUGY-UHFFFAOYSA-N 190987 US10077266, Example 100::US9181249, 100::US9708313, 100 G-protein coupled receptor 6 Human 57200 US Patent 10.7270/Q2ZP4858 aid1795210 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190987 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190987&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118180378 316936248 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494550 FC(F)CNc1nc2CN(CCc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(=O)C(F)F InChI=1S/C22H23F6N5O2/c23-12-1-2-17(14(24)9-12)35-13-3-6-32(7-4-13)21-20(29-10-18(25)26)30-16-11-33(22(34)19(27)28)8-5-15(16)31-21/h1-2,9,13,18-19H,3-8,10-11H2,(H,29,30) PEDBETLWIDHFSD-UHFFFAOYSA-N 190988 US10077266, Example 101::US9181249, 101::US9708313, 101 G-protein coupled receptor 6 Human 78800 US Patent 10.7270/Q2ZP4858 aid1795210 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190988 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190988&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159293 316936249 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494551 CO[C@@H](C)C(=O)N1CCc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(NCC(F)F)nc2C1 InChI=1S/C24H29F4N5O3/c1-14(35-2)24(34)33-10-7-18-19(13-33)30-22(29-12-21(27)28)23(31-18)32-8-5-16(6-9-32)36-20-4-3-15(25)11-17(20)26/h3-4,11,14,16,21H,5-10,12-13H2,1-2H3,(H,29,30)/t14-/m0/s1 RDXSNOSVIFKOPG-AWEZNQCLSA-N 190989 US10077266, Example 102::US9181249, 102::US9708313, 102 G-protein coupled receptor 6 Human 111000 US Patent 10.7270/Q2ZP4858 aid1795210 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190989 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190989&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159237 316936250 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494552 CO[C@H](C)C(=O)N1CCc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(NCC(F)F)nc2C1 InChI=1S/C24H29F4N5O3/c1-14(35-2)24(34)33-10-7-18-19(13-33)30-22(29-12-21(27)28)23(31-18)32-8-5-16(6-9-32)36-20-4-3-15(25)11-17(20)26/h3-4,11,14,16,21H,5-10,12-13H2,1-2H3,(H,29,30)/t14-/m1/s1 RDXSNOSVIFKOPG-CQSZACIVSA-N 190990 US10077266, Example 103::US9181249, 103::US9708313, 103 G-protein coupled receptor 6 Human 64000 US Patent 10.7270/Q2ZP4858 aid1795210 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190990 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190990&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159340 316936251 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494553 CC1Cc2nc(NCC(F)F)c(nc2CN1C(C)=O)N1CCC(CC1)Oc1ccc(F)cc1F InChI=1S/C23H27F4N5O2/c1-13-9-18-19(12-32(13)14(2)33)30-23(22(29-18)28-11-21(26)27)31-7-5-16(6-8-31)34-20-4-3-15(24)10-17(20)25/h3-4,10,13,16,21H,5-9,11-12H2,1-2H3,(H,28,29) BEIMMJQYRZFALE-UHFFFAOYSA-N 190994 US10077266, Example 107::US9181249, 107::US9708313, 107 G-protein coupled receptor 6 Human 24900 US Patent 10.7270/Q2ZP4858 aid1795210 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190994 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190994&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159131 316936252 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494554 CC1Cc2nc(NCC(F)F)c(nc2CN1C(=O)N(C)C)N1CCC(CC1)Oc1ccc(F)cc1F InChI=1S/C24H30F4N6O2/c1-14-10-18-19(13-34(14)24(35)32(2)3)31-23(22(30-18)29-12-21(27)28)33-8-6-16(7-9-33)36-20-5-4-15(25)11-17(20)26/h4-5,11,14,16,21H,6-10,12-13H2,1-3H3,(H,29,30) QPASDCWRWVFGHR-UHFFFAOYSA-N 190995 US10077266, Example 108::US9181249, 108::US9708313, 108 G-protein coupled receptor 6 Human 31400 US Patent 10.7270/Q2ZP4858 aid1795210 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190995 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190995&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159260 316936253 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494555 CC1Cc2nc(NCC(F)F)c(nc2CN1C)N1CCC(CC1)Oc1ccc(F)cc1F InChI=1S/C22H27F4N5O/c1-13-9-17-18(12-30(13)2)29-22(21(28-17)27-11-20(25)26)31-7-5-15(6-8-31)32-19-4-3-14(23)10-16(19)24/h3-4,10,13,15,20H,5-9,11-12H2,1-2H3,(H,27,28) WEPYKHOJTKMFPG-UHFFFAOYSA-N 190996 US10077266, Example 109::US9181249, 109::US9708313, 109 G-protein coupled receptor 6 Human 23200 US Patent 10.7270/Q2ZP4858 aid1795210 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190996 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190996&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159391 316936254 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494556 CC1Cc2nc(NCC(F)F)c(nc2CN1C(=O)C(F)F)N1CCC(CC1)Oc1ccc(F)cc1F InChI=1S/C23H25F6N5O2/c1-12-8-16-17(11-34(12)23(35)20(28)29)32-22(21(31-16)30-10-19(26)27)33-6-4-14(5-7-33)36-18-3-2-13(24)9-15(18)25/h2-3,9,12,14,19-20H,4-8,10-11H2,1H3,(H,30,31) WREVJMIEEVIOQY-UHFFFAOYSA-N 190997 US10077266, Example 110::US9181249, 110::US9708313, 110 G-protein coupled receptor 6 Human 22100 US Patent 10.7270/Q2ZP4858 aid1795210 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190997 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190997&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159241 316936255 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494557 COCC(=O)N1Cc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(NCC(F)F)nc2CC1C InChI=1S/C24H29F4N5O3/c1-14-9-18-19(12-33(14)22(34)13-35-2)31-24(23(30-18)29-11-21(27)28)32-7-5-16(6-8-32)36-20-4-3-15(25)10-17(20)26/h3-4,10,14,16,21H,5-9,11-13H2,1-2H3,(H,29,30) WMGUSMNEKHKMHA-UHFFFAOYSA-N 190998 US10077266, Example 111::US9181249, 111::US9708313, 111 G-protein coupled receptor 6 Human 23000 US Patent 10.7270/Q2ZP4858 aid1795210 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190998 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190998&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159295 316936256 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494558 CC1Cc2nc(NCC(F)F)c(nc2CN1S(C)(=O)=O)N1CCC(CC1)Oc1ccc(F)cc1F InChI=1S/C22H27F4N5O3S/c1-13-9-17-18(12-31(13)35(2,32)33)29-22(21(28-17)27-11-20(25)26)30-7-5-15(6-8-30)34-19-4-3-14(23)10-16(19)24/h3-4,10,13,15,20H,5-9,11-12H2,1-2H3,(H,27,28) BNECLYPVBLBWJE-UHFFFAOYSA-N 190999 US10077266, Example 112::US9181249, 112::US9708313, 112 G-protein coupled receptor 6 Human 10400 US Patent 10.7270/Q2ZP4858 aid1795210 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190999 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190999&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159264 316936257 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494559 CO[C@@H](C)C(=O)N1Cc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(NCC(F)F)nc2CC1C InChI=1S/C25H31F4N5O3/c1-14-10-19-20(13-34(14)25(35)15(2)36-3)32-24(23(31-19)30-12-22(28)29)33-8-6-17(7-9-33)37-21-5-4-16(26)11-18(21)27/h4-5,11,14-15,17,22H,6-10,12-13H2,1-3H3,(H,30,31)/t14?,15-/m0/s1 CNIJPVCRGBRADO-LOACHALJSA-N 191000 US10077266, Example 113::US9181249, 113::US9708313, 113 G-protein coupled receptor 6 Human 20900 US Patent 10.7270/Q2ZP4858 aid1795210 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=191000 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=191000&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159270 316936258 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494560 CO[C@H](C)C(=O)N1Cc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(NCC(F)F)nc2CC1C InChI=1S/C25H31F4N5O3/c1-14-10-19-20(13-34(14)25(35)15(2)36-3)32-24(23(31-19)30-12-22(28)29)33-8-6-17(7-9-33)37-21-5-4-16(26)11-18(21)27/h4-5,11,14-15,17,22H,6-10,12-13H2,1-3H3,(H,30,31)/t14?,15-/m1/s1 CNIJPVCRGBRADO-YSSOQSIOSA-N 191001 US10077266, Example 114::US9181249, 114::US9708313, 114 G-protein coupled receptor 6 Human 18500 US Patent 10.7270/Q2ZP4858 aid1795210 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=191001 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=191001&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159308 316936259 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494561 CC1Cc2nc(NCC(F)F)c(nc2CN1C(=O)C1CC1)N1CCC(CC1)Oc1ccc(F)cc1F InChI=1S/C25H29F4N5O2/c1-14-10-19-20(13-34(14)25(35)15-2-3-15)32-24(23(31-19)30-12-22(28)29)33-8-6-17(7-9-33)36-21-5-4-16(26)11-18(21)27/h4-5,11,14-15,17,22H,2-3,6-10,12-13H2,1H3,(H,30,31) RKCKCWRACZCCFE-UHFFFAOYSA-N 191002 US10077266, Example 115::US9181249, 115::US9708313, 115 G-protein coupled receptor 6 Human 23900 US Patent 10.7270/Q2ZP4858 aid1795210 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=191002 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=191002&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159159 316936260 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494562 CC(C)Nc1nc2CCN(CC(F)F)Cc2nc1N1CCC(CC1)Oc1ccc(F)cc1F InChI=1S/C23H29F4N5O/c1-14(2)28-22-23(30-19-12-31(13-21(26)27)8-7-18(19)29-22)32-9-5-16(6-10-32)33-20-4-3-15(24)11-17(20)25/h3-4,11,14,16,21H,5-10,12-13H2,1-2H3,(H,28,29) ZATIEATULNKCIF-UHFFFAOYSA-N 191003 US10077266, Example 116::US9181249, 116::US9708313, 116 G-protein coupled receptor 6 Human 199700 US Patent 10.7270/Q2ZP4858 aid1795209 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=191003 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=191003&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159142 316936261 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494563 CC(C)Nc1nc2CN(CCc2nc1N1CCC(CC1)[C@H](F)c1ccc(F)cc1F)C(C)=O InChI=1S/C24H30F3N5O/c1-14(2)28-23-24(30-20-8-11-32(15(3)33)13-21(20)29-23)31-9-6-16(7-10-31)22(27)18-5-4-17(25)12-19(18)26/h4-5,12,14,16,22H,6-11,13H2,1-3H3,(H,28,29)/t22-/m0/s1 TZLIJUSGPVQVEO-QFIPXVFZSA-N 191004 US10077266, Example 117::US9181249, 117::US9708313, 117 G-protein coupled receptor 6 Human 27400 US Patent 10.7270/Q2ZP4858 aid1795209 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=191004 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=191004&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159327 316936262 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494564 CC(C)Nc1nc2CN(CCc2nc1N1CCC(CC1)[C@H](F)c1ccc(F)cc1F)C=O InChI=1S/C23H28F3N5O/c1-14(2)27-22-23(29-19-7-8-30(13-32)12-20(19)28-22)31-9-5-15(6-10-31)21(26)17-4-3-16(24)11-18(17)25/h3-4,11,13-15,21H,5-10,12H2,1-2H3,(H,27,28)/t21-/m0/s1 HEUAXVUHAAMCND-NRFANRHFSA-N 191005 US10077266, Example 118::US9181249, 118::US9708313, 118 G-protein coupled receptor 6 Human 11400 US Patent 10.7270/Q2ZP4858 aid1795209 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=191005 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=191005&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159387 316936263 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494565 CC(C)Nc1nc2CN(CCc2nc1N1CCC(CC1)[C@@H](F)c1ccc(F)cc1F)C=O InChI=1S/C23H28F3N5O/c1-14(2)27-22-23(29-19-7-8-30(13-32)12-20(19)28-22)31-9-5-15(6-10-31)21(26)17-4-3-16(24)11-18(17)25/h3-4,11,13-15,21H,5-10,12H2,1-2H3,(H,27,28)/t21-/m1/s1 HEUAXVUHAAMCND-OAQYLSRUSA-N 191006 US10077266, Example 119::US9181249, 119::US9708313, 119 G-protein coupled receptor 6 Human 23600 US Patent 10.7270/Q2ZP4858 aid1795209 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=191006 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=191006&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159126 316936264 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494566 CC(C)Nc1nc2CCN(Cc2nc1N1CCC(CC1)S(=O)(=O)c1cccc(F)c1)C(C)=O InChI=1S/C23H30FN5O3S/c1-15(2)25-22-23(27-21-14-29(16(3)30)12-9-20(21)26-22)28-10-7-18(8-11-28)33(31,32)19-6-4-5-17(24)13-19/h4-6,13,15,18H,7-12,14H2,1-3H3,(H,25,26) DMHZAYPNRXURFS-UHFFFAOYSA-N 191007 US10077266, Example 120::US9181249, 120::US9708313, 120 G-protein coupled receptor 6 Human 249800 US Patent 10.7270/Q2ZP4858 aid1795209 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=191007 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=191007&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159384 316936265 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494567 COc1cccc(c1)S(=O)(=O)C1CCN(CC1)c1nc2CN(CCc2nc1NC(C)C)C(C)=O InChI=1S/C24H33N5O4S/c1-16(2)25-23-24(27-22-15-29(17(3)30)13-10-21(22)26-23)28-11-8-19(9-12-28)34(31,32)20-7-5-6-18(14-20)33-4/h5-7,14,16,19H,8-13,15H2,1-4H3,(H,25,26) NBYHCUZRCFOGAJ-UHFFFAOYSA-N 191008 US10077266, Example 121::US9181249, 121::US9708313, 121 G-protein coupled receptor 6 Human 341500 US Patent 10.7270/Q2ZP4858 aid1795209 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=191008 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=191008&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159155 316936266 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494568 CC(C)Nc1nc2CCN(Cc2nc1N1CCC(CC1)S(=O)(=O)c1ccccc1F)C(C)=O InChI=1S/C23H30FN5O3S/c1-15(2)25-22-23(27-20-14-29(16(3)30)13-10-19(20)26-22)28-11-8-17(9-12-28)33(31,32)21-7-5-4-6-18(21)24/h4-7,15,17H,8-14H2,1-3H3,(H,25,26) AITZOYIAARKTBL-UHFFFAOYSA-N 191009 US10077266, Example 122::US9181249, 122::US9708313, 122 G-protein coupled receptor 6 Human 247000 US Patent 10.7270/Q2ZP4858 aid1795209 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=191009 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=191009&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159336 316936267 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494569 CC(C)Nc1nc2CCN(Cc2nc1N1CCC(CC1)S(=O)(=O)c1ccc(F)cc1)C(C)=O InChI=1S/C23H30FN5O3S/c1-15(2)25-22-23(27-21-14-29(16(3)30)13-10-20(21)26-22)28-11-8-19(9-12-28)33(31,32)18-6-4-17(24)5-7-18/h4-7,15,19H,8-14H2,1-3H3,(H,25,26) DATMUIHVACAMGB-UHFFFAOYSA-N 191010 US10077266, Example 123::US9181249, 123::US9708313, 123 G-protein coupled receptor 6 Human 187700 US Patent 10.7270/Q2ZP4858 aid1795209 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=191010 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=191010&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159373 316936268 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494570 CC(C)Nc1nc2CCN(Cc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C=O InChI=1S/C22H27F2N5O2/c1-14(2)25-21-22(27-19-12-28(13-30)8-7-18(19)26-21)29-9-5-16(6-10-29)31-20-4-3-15(23)11-17(20)24/h3-4,11,13-14,16H,5-10,12H2,1-2H3,(H,25,26) NVVKRJWWRHNYKD-UHFFFAOYSA-N 191011 US10077266, Example 124::US9181249, 124::US9708313, 124 G-protein coupled receptor 6 Human 43200 US Patent 10.7270/Q2ZP4858 aid1795209 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=191011 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=191011&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159313 316936269 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494571 COc1ccc(c(F)c1)S(=O)(=O)C1CCN(CC1)c1nc2CN(CCc2nc1NC(C)C)C(C)=O InChI=1S/C24H32FN5O4S/c1-15(2)26-23-24(28-21-14-30(16(3)31)12-9-20(21)27-23)29-10-7-18(8-11-29)35(32,33)22-6-5-17(34-4)13-19(22)25/h5-6,13,15,18H,7-12,14H2,1-4H3,(H,26,27) LJYOHQZAIKVRIW-UHFFFAOYSA-N 191012 US10077266, Example 125::US9181249, 125::US9708313, 125 G-protein coupled receptor 6 Human 200200 US Patent 10.7270/Q2ZP4858 aid1795209 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=191012 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=191012&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159234 316936270 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494572 C[C@@H](CCO)Nc1nc2CN(CCc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(C)=O InChI=1S/C24H31F2N5O3/c1-15(8-12-32)27-23-24(29-20-7-11-31(16(2)33)14-21(20)28-23)30-9-5-18(6-10-30)34-22-4-3-17(25)13-19(22)26/h3-4,13,15,18,32H,5-12,14H2,1-2H3,(H,27,28)/t15-/m0/s1 ZNZWGTYBKXCTLK-HNNXBMFYSA-N 191013 US10077266, Example 126::US9181249, 126::US9708313, 126 G-protein coupled receptor 6 Human 107100 US Patent 10.7270/Q2ZP4858 aid1795209 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=191013 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=191013&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118180379 316936271 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494573 C[C@H](CCO)Nc1nc2CN(CCc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(C)=O InChI=1S/C24H31F2N5O3/c1-15(8-12-32)27-23-24(29-20-7-11-31(16(2)33)14-21(20)28-23)30-9-5-18(6-10-30)34-22-4-3-17(25)13-19(22)26/h3-4,13,15,18,32H,5-12,14H2,1-2H3,(H,27,28)/t15-/m1/s1 ZNZWGTYBKXCTLK-OAHLLOKOSA-N 191014 US10077266, Example 127::US9181249, 127::US9708313, 127 G-protein coupled receptor 6 Human >1000000 US Patent 10.7270/Q2ZP4858 aid1795209 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=191014 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=191014&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118180380 316936272 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494574 CC(=O)N1CCc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(NC3CCC3)nc2C1 InChI=1S/C24H29F2N5O2/c1-15(32)31-12-9-20-21(14-31)28-23(27-17-3-2-4-17)24(29-20)30-10-7-18(8-11-30)33-22-6-5-16(25)13-19(22)26/h5-6,13,17-18H,2-4,7-12,14H2,1H3,(H,27,28) SDXUZJWLAKFJRH-UHFFFAOYSA-N 191015 US10077266, Example 128::US9181249, 128::US9708313, 128 G-protein coupled receptor 6 Human 55000 US Patent 10.7270/Q2ZP4858 aid1795209 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=191015 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=191015&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159161 316936273 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494575 CC[C@H](C)Nc1nc2CN(CCc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(C)=O InChI=1S/C24H31F2N5O2/c1-4-15(2)27-23-24(29-20-9-12-31(16(3)32)14-21(20)28-23)30-10-7-18(8-11-30)33-22-6-5-17(25)13-19(22)26/h5-6,13,15,18H,4,7-12,14H2,1-3H3,(H,27,28)/t15-/m0/s1 IGMLEGVHEJODOR-HNNXBMFYSA-N 191017 US10077266, Example 129::US9181249, 129::US9708313, 129 G-protein coupled receptor 6 Human 62000 US Patent 10.7270/Q2ZP4858 aid1795209 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=191017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=191017&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159206 316936274 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494576 CC[C@@H](C)Nc1nc2CN(CCc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(C)=O InChI=1S/C24H31F2N5O2/c1-4-15(2)27-23-24(29-20-9-12-31(16(3)32)14-21(20)28-23)30-10-7-18(8-11-30)33-22-6-5-17(25)13-19(22)26/h5-6,13,15,18H,4,7-12,14H2,1-3H3,(H,27,28)/t15-/m1/s1 IGMLEGVHEJODOR-OAHLLOKOSA-N 191018 US10077266, Example 130::US9181249, 130::US9708313, 130 G-protein coupled receptor 6 Human 319300 US Patent 10.7270/Q2ZP4858 aid1795209 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=191018 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=191018&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159199 316936275 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494577 CCC(=O)N1CCc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(NC(C)C)nc2C1 InChI=1S/C24H31F2N5O2/c1-4-22(32)31-12-9-19-20(14-31)28-23(27-15(2)3)24(29-19)30-10-7-17(8-11-30)33-21-6-5-16(25)13-18(21)26/h5-6,13,15,17H,4,7-12,14H2,1-3H3,(H,27,28) BOKJSHWVCIWGHN-UHFFFAOYSA-N 191019 US10077266, Example 131::US9181249, 131::US9708313, 131 G-protein coupled receptor 6 Human 27600 US Patent 10.7270/Q2ZP4858 aid1795209 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=191019 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=191019&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159148 316936276 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494578 COC(=O)N1CCc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(NC(C)C)nc2C1 InChI=1S/C23H29F2N5O3/c1-14(2)26-21-22(28-18-8-11-30(23(31)32-3)13-19(18)27-21)29-9-6-16(7-10-29)33-20-5-4-15(24)12-17(20)25/h4-5,12,14,16H,6-11,13H2,1-3H3,(H,26,27) SYMBZYNRAZLRAO-UHFFFAOYSA-N 191020 US10077266, Example 132::US9181249, 132::US9708313, 132 G-protein coupled receptor 6 Human 129500 US Patent 10.7270/Q2ZP4858 aid1795209 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=191020 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=191020&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159177 316936277 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494579 CC(C)Nc1nc2CN(CCF)CCc2nc1N1CCC(CC1)Oc1ccc(F)cc1F InChI=1S/C23H30F3N5O/c1-15(2)27-22-23(29-19-7-9-30(12-8-24)14-20(19)28-22)31-10-5-17(6-11-31)32-21-4-3-16(25)13-18(21)26/h3-4,13,15,17H,5-12,14H2,1-2H3,(H,27,28) HTZPLPXSOKGAHL-UHFFFAOYSA-N 191021 US10077266, Example 133::US9181249, 133::US9708313, 133 G-protein coupled receptor 6 Human 74800 US Patent 10.7270/Q2ZP4858 aid1795209 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=191021 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=191021&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159314 316936278 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494580 CC(C)Nc1nc2CN(CCc2nc1N1CCN(Cc2ccc(F)cc2F)CC1)C(C)=O InChI=1S/C23H30F2N6O/c1-15(2)26-22-23(28-20-6-7-31(16(3)32)14-21(20)27-22)30-10-8-29(9-11-30)13-17-4-5-18(24)12-19(17)25/h4-5,12,15H,6-11,13-14H2,1-3H3,(H,26,27) OZCTVPBBFJSIPB-UHFFFAOYSA-N 191022 US10077266, Example 134::US9181249, 134::US9708313, 134 G-protein coupled receptor 6 Human 27000 US Patent 10.7270/Q2ZP4858 aid1795209 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=191022 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=191022&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159375 316936279 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494581 CC(=O)N1CCc2nc(N3CCN(Cc4ccc(F)cc4F)CC3)c(NC3CCC3)nc2C1 InChI=1S/C24H30F2N6O/c1-16(33)32-8-7-21-22(15-32)28-23(27-19-3-2-4-19)24(29-21)31-11-9-30(10-12-31)14-17-5-6-18(25)13-20(17)26/h5-6,13,19H,2-4,7-12,14-15H2,1H3,(H,27,28) OLCPSLUHIDGRAC-UHFFFAOYSA-N 191023 US10077266, Example 135::US9181249, 135::US9708313, 135 G-protein coupled receptor 6 Human 43700 US Patent 10.7270/Q2ZP4858 aid1795209 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=191023 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=191023&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159165 316936280 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494582 CC(C)Nc1nc2CN(CCc2nc1N1CCN(Cc2ccc(F)cc2F)CC1)S(C)(=O)=O InChI=1S/C22H30F2N6O2S/c1-15(2)25-21-22(27-19-6-7-30(33(3,31)32)14-20(19)26-21)29-10-8-28(9-11-29)13-16-4-5-17(23)12-18(16)24/h4-5,12,15H,6-11,13-14H2,1-3H3,(H,25,26) LLDFGRFJUUBZCG-UHFFFAOYSA-N 191024 US10077266, Example 136::US9181249, 136::US9708313, 136 G-protein coupled receptor 6 Human 27900 US Patent 10.7270/Q2ZP4858 aid1795209 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=191024 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=191024&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159178 316936281 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494583 CCC(=O)N1CCc2nc(N3CCN(Cc4ccc(F)cc4F)CC3)c(NC(C)C)nc2C1 InChI=1S/C24H32F2N6O/c1-4-22(33)32-8-7-20-21(15-32)28-23(27-16(2)3)24(29-20)31-11-9-30(10-12-31)14-17-5-6-18(25)13-19(17)26/h5-6,13,16H,4,7-12,14-15H2,1-3H3,(H,27,28) RASASWOICGGBDJ-UHFFFAOYSA-N 191025 US10077266, Example 137::US9181249, 137::US9708313, 137 G-protein coupled receptor 6 Human 30900 US Patent 10.7270/Q2ZP4858 aid1795209 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=191025 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=191025&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159125 316936282 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494584 CC(C)Nc1nc2CN(CCc2nc1N1CCN(CC1)C(=O)OC(C)(C)C)C(C)=O InChI=1S/C21H34N6O3/c1-14(2)22-18-19(24-16-7-8-27(15(3)28)13-17(16)23-18)25-9-11-26(12-10-25)20(29)30-21(4,5)6/h14H,7-13H2,1-6H3,(H,22,23) CJEZYFCOYOMTCD-UHFFFAOYSA-N 191026 US10077266, Example 138::US9181249, 138::US9708313, 138 G-protein coupled receptor 6 Human >1000000 US Patent 10.7270/Q2ZP4858 aid1795209 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=191026 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=191026&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159271 316936283 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494585 CC(=O)O[C@@H]1C[C@@H](C1)Nc1nc2CN(CCc2nc1N1CCN(Cc2ccc(F)cc2F)CC1)C(C)=O InChI=1S/C26H32F2N6O3/c1-16(35)34-6-5-23-24(15-34)30-25(29-20-12-21(13-20)37-17(2)36)26(31-23)33-9-7-32(8-10-33)14-18-3-4-19(27)11-22(18)28/h3-4,11,20-21H,5-10,12-15H2,1-2H3,(H,29,30)/t20-,21+ JVADGRPSAFEECF-OYRHEFFESA-N 191027 US10077266, Example 139::US9181249, 139::US9708313, 139 G-protein coupled receptor 6 Human 219800 US Patent 10.7270/Q2ZP4858 aid1795209 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=191027 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=191027&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159193 316936284 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494586 CC(=O)N1CCc2nc(N3CCN(Cc4ccc(F)cc4F)CC3)c(N[C@@H]3C[C@H](O)C3)nc2C1 InChI=1S/C24H30F2N6O2/c1-15(33)32-5-4-21-22(14-32)28-23(27-18-11-19(34)12-18)24(29-21)31-8-6-30(7-9-31)13-16-2-3-17(25)10-20(16)26/h2-3,10,18-19,34H,4-9,11-14H2,1H3,(H,27,28)/t18-,19+ OSLYLLNWGUKDPP-KDURUIRLSA-N 191028 US10077266, Example 140::US9181249, 140::US9708313, 140 G-protein coupled receptor 6 Human 122000 US Patent 10.7270/Q2ZP4858 aid1795209 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=191028 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=191028&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159238 316936285 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494587 CC(C)Nc1nc2CN(CCc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(C)=O InChI=1S/C23H29F2N5O2/c1-14(2)26-22-23(28-19-8-11-30(15(3)31)13-20(19)27-22)29-9-6-17(7-10-29)32-21-5-4-16(24)12-18(21)25/h4-5,12,14,17H,6-11,13H2,1-3H3,(H,26,27) FSUXDPIOBQLEKO-UHFFFAOYSA-N 190936 US10077266, Example 141::US9181249, 141::US9181249, 47::US9708313, 141 G-protein coupled receptor 6 Human 33700 US Patent 10.7270/Q2ZP4858 aid1795209 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190936 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190936&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 91810771 316936200 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494588 CC(=O)O[C@@H]1C[C@@H](C1)Nc1nc2CN(CCc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(C)=O InChI=1S/C26H31F2N5O4/c1-15(34)33-10-7-22-23(14-33)30-25(29-18-12-20(13-18)36-16(2)35)26(31-22)32-8-5-19(6-9-32)37-24-4-3-17(27)11-21(24)28/h3-4,11,18-20H,5-10,12-14H2,1-2H3,(H,29,30)/t18-,20+ FHDHUFKLDXIYOW-PUZFROQSSA-N 191030 US10077266, Example 142::US9181249, 142::US9708313, 142 G-protein coupled receptor 6 Human 113500 US Patent 10.7270/Q2ZP4858 aid1795209 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=191030 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=191030&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159128 316936286 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494589 CC(C)Nc1nc2CN(CCc2nc1N1CCN(Cc2ccc(F)cc2F)CC1)C(=O)C(C)C InChI=1S/C25H34F2N6O/c1-16(2)25(34)33-8-7-21-22(15-33)29-23(28-17(3)4)24(30-21)32-11-9-31(10-12-32)14-18-5-6-19(26)13-20(18)27/h5-6,13,16-17H,7-12,14-15H2,1-4H3,(H,28,29) IWFKEJLLLIHOQD-UHFFFAOYSA-N 191031 US10077266, Example 143::US9181249, 143::US9708313, 143 G-protein coupled receptor 6 Human 29000 US Patent 10.7270/Q2ZP4858 aid1795209 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=191031 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=191031&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159229 316936287 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494590 CC(=O)N1CCc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(N[C@@H]3C[C@H](O)C3)nc2C1 InChI=1S/C24H29F2N5O3/c1-14(32)31-9-6-20-21(13-31)28-23(27-16-11-17(33)12-16)24(29-20)30-7-4-18(5-8-30)34-22-3-2-15(25)10-19(22)26/h2-3,10,16-18,33H,4-9,11-13H2,1H3,(H,27,28)/t16-,17+ HRCVXNPXGOAGEG-CALCHBBNSA-N 191032 US10077266, Example 144::US9181249, 144::US9708313, 144 G-protein coupled receptor 6 Human 61500 US Patent 10.7270/Q2ZP4858 aid1795209 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=191032 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=191032&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159301 316936288 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494591 CC(=O)N1CCc2nc(N3CCN(Cc4ccc(F)cc4F)CC3)c(N[C@H]3C[C@H](F)C3)nc2C1 InChI=1S/C24H29F3N6O/c1-15(34)33-5-4-21-22(14-33)29-23(28-19-10-18(26)11-19)24(30-21)32-8-6-31(7-9-32)13-16-2-3-17(25)12-20(16)27/h2-3,12,18-19H,4-11,13-14H2,1H3,(H,28,29)/t18-,19- GDSHKCXYHIWACP-WGSAOQKQSA-N 191033 US10077266, Example 145::US9181249, 145::US9708313, 145 G-protein coupled receptor 6 Human 185900 US Patent 10.7270/Q2ZP4858 aid1795209 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=191033 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=191033&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159145 316936289 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494592 CC(C)Nc1nc2CN(CCc2nc1N1CCN(Cc2ccc(cc2F)C#N)CC1)C(C)=O InChI=1S/C24H30FN7O/c1-16(2)27-23-24(29-21-6-7-32(17(3)33)15-22(21)28-23)31-10-8-30(9-11-31)14-19-5-4-18(13-26)12-20(19)25/h4-5,12,16H,6-11,14-15H2,1-3H3,(H,27,28) JGQSUMBLQLYGMA-UHFFFAOYSA-N 191034 US10077266, Example 146::US9181249, 146::US9708313, 146 G-protein coupled receptor 6 Human 362900 US Patent 10.7270/Q2ZP4858 aid1795209 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=191034 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=191034&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159118 316936290 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494593 CC(=O)O[C@H]1C[C@@H](C1)Nc1nc2CN(CCc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(C)=O InChI=1S/C26H31F2N5O4/c1-15(34)33-10-7-22-23(14-33)30-25(29-18-12-20(13-18)36-16(2)35)26(31-22)32-8-5-19(6-9-32)37-24-4-3-17(27)11-21(24)28/h3-4,11,18-20H,5-10,12-14H2,1-2H3,(H,29,30)/t18-,20- FHDHUFKLDXIYOW-KESTWPANSA-N 191035 US10077266, Example 147::US9181249, 147::US9708313, 147 G-protein coupled receptor 6 Human 603900 US Patent 10.7270/Q2ZP4858 aid1795209 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=191035 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=191035&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159128 316936291 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494594 CC(=O)N1CCc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(N[C@H]3C[C@H](O)C3)nc2C1 InChI=1S/C24H29F2N5O3/c1-14(32)31-9-6-20-21(13-31)28-23(27-16-11-17(33)12-16)24(29-20)30-7-4-18(5-8-30)34-22-3-2-15(25)10-19(22)26/h2-3,10,16-18,33H,4-9,11-13H2,1H3,(H,27,28)/t16-,17- HRCVXNPXGOAGEG-QAQDUYKDSA-N 191036 US10077266, Example 148::US9181249, 148::US9708313, 148 G-protein coupled receptor 6 Human 78000 US Patent 10.7270/Q2ZP4858 aid1795209 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=191036 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=191036&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159301 316936292 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494595 CC(=O)N1CCc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(N[C@H]3CCOC3)nc2C1 InChI=1S/C24H29F2N5O3/c1-15(32)31-10-6-20-21(13-31)28-23(27-17-7-11-33-14-17)24(29-20)30-8-4-18(5-9-30)34-22-3-2-16(25)12-19(22)26/h2-3,12,17-18H,4-11,13-14H2,1H3,(H,27,28)/t17-/m0/s1 HSWVJQBEXRKOBZ-KRWDZBQOSA-N 191037 US10077266, Example 149::US10406157, Compound A::US9181249, 149::US9708313, 149 G-protein coupled receptor 6 Human 58700 US Patent 10.7270/Q2ZP4858 aid1795209 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=191037 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=191037&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159164 316936293 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494596 CCC(=O)N1CCc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(N[C@H]3CCOC3)nc2C1 InChI=1S/C25H31F2N5O3/c1-2-23(33)32-11-7-20-21(14-32)29-24(28-17-8-12-34-15-17)25(30-20)31-9-5-18(6-10-31)35-22-4-3-16(26)13-19(22)27/h3-4,13,17-18H,2,5-12,14-15H2,1H3,(H,28,29)/t17-/m0/s1 JRJLPTCUEBFMPA-KRWDZBQOSA-N 191038 US10077266, Example 150::US9181249, 150::US9708313, 150 G-protein coupled receptor 6 Human 39200 US Patent 10.7270/Q2ZP4858 aid1795209 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=191038 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=191038&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159189 316936294 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494597 CC(=O)N1CCc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(NC3CC(F)(F)C3)nc2C1 InChI=1S/C24H27F4N5O2/c1-14(34)33-9-6-19-20(13-33)30-22(29-16-11-24(27,28)12-16)23(31-19)32-7-4-17(5-8-32)35-21-3-2-15(25)10-18(21)26/h2-3,10,16-17H,4-9,11-13H2,1H3,(H,29,30) KCSNHUSEVYLGAW-UHFFFAOYSA-N 191039 US10077266, Example 151::US9181249, 151::US9708313, 151 G-protein coupled receptor 6 Human 35900 US Patent 10.7270/Q2ZP4858 aid1795209 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=191039 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=191039&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159309 316936295 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494598 CS(=O)(=O)N1CCc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(NC3CCC3)nc2C1 InChI=1S/C23H29F2N5O3S/c1-34(31,32)30-12-9-19-20(14-30)27-22(26-16-3-2-4-16)23(28-19)29-10-7-17(8-11-29)33-21-6-5-15(24)13-18(21)25/h5-6,13,16-17H,2-4,7-12,14H2,1H3,(H,26,27) RJZHGBONFGIONP-UHFFFAOYSA-N 191040 US10077266, Example 152::US9181249, 152::US9708313, 152 G-protein coupled receptor 6 Human 49300 US Patent 10.7270/Q2ZP4858 aid1795209 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=191040 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=191040&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159205 316936296 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494599 CC(=O)N1CCc2nc(N3CCN(Cc4ccc(F)cc4F)CC3)c(N[C@@H]3CCOC3)nc2C1 InChI=1S/C24H30F2N6O2/c1-16(33)32-6-4-21-22(14-32)28-23(27-19-5-11-34-15-19)24(29-21)31-9-7-30(8-10-31)13-17-2-3-18(25)12-20(17)26/h2-3,12,19H,4-11,13-15H2,1H3,(H,27,28)/t19-/m1/s1 DDOBOIJPLXJEPX-LJQANCHMSA-N 191041 US10077266, Example 153::US9181249, 153::US9708313, 153 G-protein coupled receptor 6 Human 63200 US Patent 10.7270/Q2ZP4858 aid1795209 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=191041 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=191041&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159217 316936297 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494600 CC(=O)N1CCc2nc(N3CCN(Cc4ccc(F)cc4F)CC3)c(N[C@H]3CCOC3)nc2C1 InChI=1S/C24H30F2N6O2/c1-16(33)32-6-4-21-22(14-32)28-23(27-19-5-11-34-15-19)24(29-21)31-9-7-30(8-10-31)13-17-2-3-18(25)12-20(17)26/h2-3,12,19H,4-11,13-15H2,1H3,(H,27,28)/t19-/m0/s1 DDOBOIJPLXJEPX-IBGZPJMESA-N 191042 US10077266, Example 154::US9181249, 154::US9708313, 154 G-protein coupled receptor 6 Human 97800 US Patent 10.7270/Q2ZP4858 aid1795209 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=191042 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=191042&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159198 316936298 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494601 CCC(=O)N1CCc2nc(N3CCN(Cc4ccc(F)cc4F)CC3)c(N[C@H]3CCOC3)nc2C1 InChI=1S/C25H32F2N6O2/c1-2-23(34)33-7-5-21-22(15-33)29-24(28-19-6-12-35-16-19)25(30-21)32-10-8-31(9-11-32)14-17-3-4-18(26)13-20(17)27/h3-4,13,19H,2,5-12,14-16H2,1H3,(H,28,29)/t19-/m0/s1 IDGIOUPKISJVFS-IBGZPJMESA-N 191043 US10077266, Example 155::US9181249, 155::US9708313, 155 G-protein coupled receptor 6 Human 59100 US Patent 10.7270/Q2ZP4858 aid1795209 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=191043 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=191043&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159364 316936299 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0 494602 CC(C)Nc1nc2CCN(Cc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(C)=O InChI=1S/C23H29F2N5O2/c1-14(2)26-22-23(28-20-13-30(15(3)31)11-8-19(20)27-22)29-9-6-17(7-10-29)32-21-5-4-16(24)12-18(21)25/h4-5,12,14,17H,6-11,13H2,1-3H3,(H,26,27) GONMCTNGCPLRCY-UHFFFAOYSA-N 190969 US10077266, Example 156::US9181249, 156::US9181249, 82::US9708313, 156 G-protein coupled receptor 6 Human 9500 US Patent 10.7270/Q2ZP4858 aid1795210 US9708313 Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Monenschein, H; Reichard, H; Schleicher, K; Sun, H; Macklin, T 7/18/2017 10/31/2018 Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190969 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8027&target=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190969&enzyme=G-protein+coupled+receptor+6&column=ki&startPg=0&Increment=50&submit=Search 118159235 316936232 1 MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV G-protein coupled receptor 6 GPR6_HUMAN P46095 B4DHS9 J3KQR3 Q17RJ7 Q5SYL0