BindingDB Reactant_set_id	Ligand SMILES	Ligand InChI	Ligand InChI Key	BindingDB MonomerID	BindingDB Ligand Name	Target Name	Target Source Organism According to Curator or DataSource	Ki (nM)	IC50 (nM)	Kd (nM)	EC50 (nM)	kon (M-1-s-1)	koff (s-1)	pH	Temp (C)	Curation/DataSource	Article DOI	BindingDB Entry DOI	PMID	PubChem AID	Patent Number	Authors	Date of publication	Date in BindingDB	Institution	Link to Ligand in BindingDB	Link to Target in BindingDB	Link to Ligand-Target Pair in BindingDB	Ligand HET ID in PDB	PDB ID(s) for Ligand-Target Complex	PubChem CID	PubChem SID	ChEBI ID of Ligand	ChEMBL ID of Ligand	DrugBank ID of Ligand	IUPHAR_GRAC ID of Ligand	KEGG ID of Ligand	ZINC ID of Ligand	Number of Protein Chains in Target (>1 implies a multichain complex)	BindingDB Target Chain Sequence 1	PDB ID(s) of Target Chain 1	UniProt (SwissProt) Recommended Name of Target Chain 1	UniProt (SwissProt) Entry Name of Target Chain 1	UniProt (SwissProt) Primary ID of Target Chain 1	UniProt (SwissProt) Secondary ID(s) of Target Chain 1	UniProt (SwissProt) Alternative ID(s) of Target Chain 1	UniProt (TrEMBL) Submitted Name of Target Chain 1	UniProt (TrEMBL) Entry Name of Target Chain 1	UniProt (TrEMBL) Primary ID of Target Chain 1	UniProt (TrEMBL) Secondary ID(s) of Target Chain 1	UniProt (TrEMBL) Alternative ID(s) of Target Chain 1	BindingDB Target Chain Sequence 2	PDB ID(s) of Target Chain 2	UniProt (SwissProt) Recommended Name of Target Chain 2	UniProt (SwissProt) Entry Name of Target Chain 2	UniProt (SwissProt) Primary ID of Target Chain 2	UniProt (SwissProt) Secondary ID(s) of Target Chain 2	UniProt (SwissProt) Alternative ID(s) of Target Chain 2	UniProt (TrEMBL) Submitted Name of Target Chain 2	UniProt (TrEMBL) Entry Name of Target Chain 2	UniProt (TrEMBL) Primary ID of Target Chain 2	UniProt (TrEMBL) Secondary ID(s) of Target Chain 2	UniProt (TrEMBL) Alternative ID(s) of Target Chain 2	BindingDB Target Chain Sequence 3	PDB ID(s) of Target Chain 3	UniProt (SwissProt) Recommended Name of Target Chain 3	UniProt (SwissProt) Entry Name of Target Chain 3	UniProt (SwissProt) Primary ID of Target Chain 3	UniProt (SwissProt) Secondary ID(s) of Target Chain 3	UniProt (SwissProt) Alternative ID(s) of Target Chain 3	UniProt (TrEMBL) Submitted Name of Target Chain 3	UniProt (TrEMBL) Entry Name of Target Chain 3	UniProt (TrEMBL) Primary ID of Target Chain 3	UniProt (TrEMBL) Secondary ID(s) of Target Chain 3	UniProt (TrEMBL) Alternative ID(s) of Target Chain 3	BindingDB Target Chain Sequence 4	PDB ID(s) of Target Chain 4	UniProt (SwissProt) Recommended Name of Target Chain 4	UniProt (SwissProt) Entry Name of Target Chain 4	UniProt (SwissProt) Primary ID of Target Chain 4	UniProt (SwissProt) Secondary ID(s) of Target Chain 4	UniProt (SwissProt) Alternative ID(s) of Target Chain 4	UniProt (TrEMBL) Submitted Name of Target Chain 4	UniProt (TrEMBL) Entry Name of Target Chain 4	UniProt (TrEMBL) Primary ID of Target Chain 4	UniProt (TrEMBL) Secondary ID(s) of Target Chain 4	UniProt (TrEMBL) Alternative ID(s) of Target Chain 4	BindingDB Target Chain Sequence 5	PDB ID(s) of Target Chain 5	UniProt (SwissProt) Recommended Name of Target Chain 5	UniProt (SwissProt) Entry Name of Target Chain 5	UniProt (SwissProt) Primary ID of Target Chain 5	UniProt (SwissProt) Secondary ID(s) of Target Chain 5	UniProt (SwissProt) Alternative ID(s) of Target Chain 5	UniProt (TrEMBL) Submitted Name of Target Chain 5	UniProt (TrEMBL) Entry Name of Target Chain 5	UniProt (TrEMBL) Primary ID of Target Chain 5	UniProt (TrEMBL) Secondary ID(s) of Target Chain 5	UniProt (TrEMBL) Alternative ID(s) of Target Chain 5	BindingDB Target Chain Sequence 6	PDB ID(s) of Target Chain 6	UniProt (SwissProt) Recommended Name of Target Chain 6	UniProt (SwissProt) Entry Name of Target Chain 6	UniProt (SwissProt) Primary ID of Target Chain 6	UniProt (SwissProt) Secondary ID(s) of Target Chain 6	UniProt (SwissProt) Alternative ID(s) of Target Chain 6	UniProt (TrEMBL) Submitted Name of Target Chain 6	UniProt (TrEMBL) Entry Name of Target Chain 6	UniProt (TrEMBL) Primary ID of Target Chain 6	UniProt (TrEMBL) Secondary ID(s) of Target Chain 6	UniProt (TrEMBL) Alternative ID(s) of Target Chain 6	BindingDB Target Chain Sequence 7	PDB ID(s) of Target Chain 7	UniProt (SwissProt) Recommended Name of Target Chain 7	UniProt (SwissProt) Entry Name of Target Chain 7	UniProt (SwissProt) Primary ID of Target Chain 7	UniProt (SwissProt) Secondary ID(s) of Target Chain 7	UniProt (SwissProt) Alternative ID(s) of Target Chain 7	UniProt (TrEMBL) Submitted Name of Target Chain 7	UniProt (TrEMBL) Entry Name of Target Chain 7	UniProt (TrEMBL) Primary ID of Target Chain 7	UniProt (TrEMBL) Secondary ID(s) of Target Chain 7	UniProt (TrEMBL) Alternative ID(s) of Target Chain 7	BindingDB Target Chain Sequence 8	PDB ID(s) of Target Chain 8	UniProt (SwissProt) Recommended Name of Target Chain 8	UniProt (SwissProt) Entry Name of Target Chain 8	UniProt (SwissProt) Primary ID of Target Chain 8	UniProt (SwissProt) Secondary ID(s) of Target Chain 8	UniProt (SwissProt) Alternative ID(s) of Target Chain 8	UniProt (TrEMBL) Submitted Name of Target Chain 8	UniProt (TrEMBL) Entry Name of Target Chain 8	UniProt (TrEMBL) Primary ID of Target Chain 8	UniProt (TrEMBL) Secondary ID(s) of Target Chain 8	UniProt (TrEMBL) Alternative ID(s) of Target Chain 8	BindingDB Target Chain Sequence 9	PDB ID(s) of Target Chain 9	UniProt (SwissProt) Recommended Name of Target Chain 9	UniProt (SwissProt) Entry Name of Target Chain 9	UniProt (SwissProt) Primary ID of Target Chain 9	UniProt (SwissProt) Secondary ID(s) of Target Chain 9	UniProt (SwissProt) Alternative ID(s) of Target Chain 9	UniProt (TrEMBL) Submitted Name of Target Chain 9	UniProt (TrEMBL) Entry Name of Target Chain 9	UniProt (TrEMBL) Primary ID of Target Chain 9	UniProt (TrEMBL) Secondary ID(s) of Target Chain 9	UniProt (TrEMBL) Alternative ID(s) of Target Chain 9	BindingDB Target Chain Sequence 10	PDB ID(s) of Target Chain 10	UniProt (SwissProt) Recommended Name of Target Chain 10	UniProt (SwissProt) Entry Name of Target Chain 10	UniProt (SwissProt) Primary ID of Target Chain 10	UniProt (SwissProt) Secondary ID(s) of Target Chain 10	UniProt (SwissProt) Alternative ID(s) of Target Chain 10	UniProt (TrEMBL) Submitted Name of Target Chain 10	UniProt (TrEMBL) Entry Name of Target Chain 10	UniProt (TrEMBL) Primary ID of Target Chain 10	UniProt (TrEMBL) Secondary ID(s) of Target Chain 10	UniProt (TrEMBL) Alternative ID(s) of Target Chain 10	BindingDB Target Chain Sequence 11	PDB ID(s) of Target Chain 11	UniProt (SwissProt) Recommended Name of Target Chain 11	UniProt (SwissProt) Entry Name of Target Chain 11	UniProt (SwissProt) Primary ID of Target Chain 11	UniProt (SwissProt) Secondary ID(s) of Target Chain 11	UniProt (SwissProt) Alternative ID(s) of Target Chain 11	UniProt (TrEMBL) Submitted Name of Target Chain 11	UniProt (TrEMBL) Entry Name of Target Chain 11	UniProt (TrEMBL) Primary ID of Target Chain 11	UniProt (TrEMBL) Secondary ID(s) of Target Chain 11	UniProt (TrEMBL) Alternative ID(s) of Target Chain 11	BindingDB Target Chain Sequence 12	PDB ID(s) of Target Chain 12	UniProt (SwissProt) Recommended Name of Target Chain 12	UniProt (SwissProt) Entry Name of Target Chain 12	UniProt (SwissProt) Primary ID of Target Chain 12	UniProt (SwissProt) Secondary ID(s) of Target Chain 12	UniProt (SwissProt) Alternative ID(s) of Target Chain 12	UniProt (TrEMBL) Submitted Name of Target Chain 12	UniProt (TrEMBL) Entry Name of Target Chain 12	UniProt (TrEMBL) Primary ID of Target Chain 12	UniProt (TrEMBL) Secondary ID(s) of Target Chain 12	UniProt (TrEMBL) Alternative ID(s) of Target Chain 12	BindingDB Target Chain Sequence 13	PDB ID(s) of Target Chain 13	UniProt (SwissProt) Recommended Name of Target Chain 13	UniProt (SwissProt) Entry Name of Target Chain 13	UniProt (SwissProt) Primary ID of Target Chain 13	UniProt (SwissProt) Secondary ID(s) of Target Chain 13	UniProt (SwissProt) Alternative ID(s) of Target Chain 13	UniProt (TrEMBL) Submitted Name of Target Chain 13	UniProt (TrEMBL) Entry Name of Target Chain 13	UniProt (TrEMBL) Primary ID of Target Chain 13	UniProt (TrEMBL) Secondary ID(s) of Target Chain 13	UniProt (TrEMBL) Alternative ID(s) of Target Chain 13	BindingDB Target Chain Sequence 14	PDB ID(s) of Target Chain 14	UniProt (SwissProt) Recommended Name of Target Chain 14	UniProt (SwissProt) Entry Name of Target Chain 14	UniProt (SwissProt) Primary ID of Target Chain 14	UniProt (SwissProt) Secondary ID(s) of Target Chain 14	UniProt (SwissProt) Alternative ID(s) of Target Chain 14	UniProt (TrEMBL) Submitted Name of Target Chain 14	UniProt (TrEMBL) Entry Name of Target Chain 14	UniProt (TrEMBL) Primary ID of Target Chain 14	UniProt (TrEMBL) Secondary ID(s) of Target Chain 14	UniProt (TrEMBL) Alternative ID(s) of Target Chain 14	BindingDB Target Chain Sequence 15	PDB ID(s) of Target Chain 15	UniProt (SwissProt) Recommended Name of Target Chain 15	UniProt (SwissProt) Entry Name of Target Chain 15	UniProt (SwissProt) Primary ID of Target Chain 15	UniProt (SwissProt) Secondary ID(s) of Target Chain 15	UniProt (SwissProt) Alternative ID(s) of Target Chain 15	UniProt (TrEMBL) Submitted Name of Target Chain 15	UniProt (TrEMBL) Entry Name of Target Chain 15	UniProt (TrEMBL) Primary ID of Target Chain 15	UniProt (TrEMBL) Secondary ID(s) of Target Chain 15	UniProt (TrEMBL) Alternative ID(s) of Target Chain 15	BindingDB Target Chain Sequence 16	PDB ID(s) of Target Chain 16	UniProt (SwissProt) Recommended Name of Target Chain 16	UniProt (SwissProt) Entry Name of Target Chain 16	UniProt (SwissProt) Primary ID of Target Chain 16	UniProt (SwissProt) Secondary ID(s) of Target Chain 16	UniProt (SwissProt) Alternative ID(s) of Target Chain 16	UniProt (TrEMBL) Submitted Name of Target Chain 16	UniProt (TrEMBL) Entry Name of Target Chain 16	UniProt (TrEMBL) Primary ID of Target Chain 16	UniProt (TrEMBL) Secondary ID(s) of Target Chain 16	UniProt (TrEMBL) Alternative ID(s) of Target Chain 16	BindingDB Target Chain Sequence 17	PDB ID(s) of Target Chain 17	UniProt (SwissProt) Recommended Name of Target Chain 17	UniProt (SwissProt) Entry Name of Target Chain 17	UniProt (SwissProt) Primary ID of Target Chain 17	UniProt (SwissProt) Secondary ID(s) of Target Chain 17	UniProt (SwissProt) Alternative ID(s) of Target Chain 17	UniProt (TrEMBL) Submitted Name of Target Chain 17	UniProt (TrEMBL) Entry Name of Target Chain 17	UniProt (TrEMBL) Primary ID of Target Chain 17	UniProt (TrEMBL) Secondary ID(s) of Target Chain 17	UniProt (TrEMBL) Alternative ID(s) of Target Chain 17	BindingDB Target Chain Sequence 18	PDB ID(s) of Target Chain 18	UniProt (SwissProt) Recommended Name of Target Chain 18	UniProt (SwissProt) Entry Name of Target Chain 18	UniProt (SwissProt) Primary ID of Target Chain 18	UniProt (SwissProt) Secondary ID(s) of Target Chain 18	UniProt (SwissProt) Alternative ID(s) of Target Chain 18	UniProt (TrEMBL) Submitted Name of Target Chain 18	UniProt (TrEMBL) Entry Name of Target Chain 18	UniProt (TrEMBL) Primary ID of Target Chain 18	UniProt (TrEMBL) Secondary ID(s) of Target Chain 18	UniProt (TrEMBL) Alternative ID(s) of Target Chain 18	BindingDB Target Chain Sequence 19	PDB ID(s) of Target Chain 19	UniProt (SwissProt) Recommended Name of Target Chain 19	UniProt (SwissProt) Entry Name of Target Chain 19	UniProt (SwissProt) Primary ID of Target Chain 19	UniProt (SwissProt) Secondary ID(s) of Target Chain 19	UniProt (SwissProt) Alternative ID(s) of Target Chain 19	UniProt (TrEMBL) Submitted Name of Target Chain 19	UniProt (TrEMBL) Entry Name of Target Chain 19	UniProt (TrEMBL) Primary ID of Target Chain 19	UniProt (TrEMBL) Secondary ID(s) of Target Chain 19	UniProt (TrEMBL) Alternative ID(s) of Target Chain 19	BindingDB Target Chain Sequence 20	PDB ID(s) of Target Chain 20	UniProt (SwissProt) Recommended Name of Target Chain 20	UniProt (SwissProt) Entry Name of Target Chain 20	UniProt (SwissProt) Primary ID of Target Chain 20	UniProt (SwissProt) Secondary ID(s) of Target Chain 20	UniProt (SwissProt) Alternative ID(s) of Target Chain 20	UniProt (TrEMBL) Submitted Name of Target Chain 20	UniProt (TrEMBL) Entry Name of Target Chain 20	UniProt (TrEMBL) Primary ID of Target Chain 20	UniProt (TrEMBL) Secondary ID(s) of Target Chain 20	UniProt (TrEMBL) Alternative ID(s) of Target Chain 20	BindingDB Target Chain Sequence 21	PDB ID(s) of Target Chain 21	UniProt (SwissProt) Recommended Name of Target Chain 21	UniProt (SwissProt) Entry Name of Target Chain 21	UniProt (SwissProt) Primary ID of Target Chain 21	UniProt (SwissProt) Secondary ID(s) of Target Chain 21	UniProt (SwissProt) Alternative ID(s) of Target Chain 21	UniProt (TrEMBL) Submitted Name of Target Chain 21	UniProt (TrEMBL) Entry Name of Target Chain 21	UniProt (TrEMBL) Primary ID of Target Chain 21	UniProt (TrEMBL) Secondary ID(s) of Target Chain 21	UniProt (TrEMBL) Alternative ID(s) of Target Chain 21	BindingDB Target Chain Sequence 22	PDB ID(s) of Target Chain 22	UniProt (SwissProt) Recommended Name of Target Chain 22	UniProt (SwissProt) Entry Name of Target Chain 22	UniProt (SwissProt) Primary ID of Target Chain 22	UniProt (SwissProt) Secondary ID(s) of Target Chain 22	UniProt (SwissProt) Alternative ID(s) of Target Chain 22	UniProt (TrEMBL) Submitted Name of Target Chain 22	UniProt (TrEMBL) Entry Name of Target Chain 22	UniProt (TrEMBL) Primary ID of Target Chain 22	UniProt (TrEMBL) Secondary ID(s) of Target Chain 22	UniProt (TrEMBL) Alternative ID(s) of Target Chain 22	BindingDB Target Chain Sequence 23	PDB ID(s) of Target Chain 23	UniProt (SwissProt) Recommended Name of Target Chain 23	UniProt (SwissProt) Entry Name of Target Chain 23	UniProt (SwissProt) Primary ID of Target Chain 23	UniProt (SwissProt) Secondary ID(s) of Target Chain 23	UniProt (SwissProt) Alternative ID(s) of Target Chain 23	UniProt (TrEMBL) Submitted Name of Target Chain 23	UniProt (TrEMBL) Entry Name of Target Chain 23	UniProt (TrEMBL) Primary ID of Target Chain 23	UniProt (TrEMBL) Secondary ID(s) of Target Chain 23	UniProt (TrEMBL) Alternative ID(s) of Target Chain 23	BindingDB Target Chain Sequence 24	PDB ID(s) of Target Chain 24	UniProt (SwissProt) Recommended Name of Target Chain 24	UniProt (SwissProt) Entry Name of Target Chain 24	UniProt (SwissProt) Primary ID of Target Chain 24	UniProt (SwissProt) Secondary ID(s) of Target Chain 24	UniProt (SwissProt) Alternative ID(s) of Target Chain 24	UniProt (TrEMBL) Submitted Name of Target Chain 24	UniProt (TrEMBL) Entry Name of Target Chain 24	UniProt (TrEMBL) Primary ID of Target Chain 24	UniProt (TrEMBL) Secondary ID(s) of Target Chain 24	UniProt (TrEMBL) Alternative ID(s) of Target Chain 24	BindingDB Target Chain Sequence 25	PDB ID(s) of Target Chain 25	UniProt (SwissProt) Recommended Name of Target Chain 25	UniProt (SwissProt) Entry Name of Target Chain 25	UniProt (SwissProt) Primary ID of Target Chain 25	UniProt (SwissProt) Secondary ID(s) of Target Chain 25	UniProt (SwissProt) Alternative ID(s) of Target Chain 25	UniProt (TrEMBL) Submitted Name of Target Chain 25	UniProt (TrEMBL) Entry Name of Target Chain 25	UniProt (TrEMBL) Primary ID of Target Chain 25	UniProt (TrEMBL) Secondary ID(s) of Target Chain 25	UniProt (TrEMBL) Alternative ID(s) of Target Chain 25	BindingDB Target Chain Sequence 26	PDB ID(s) of Target Chain 26	UniProt (SwissProt) Recommended Name of Target Chain 26	UniProt (SwissProt) Entry Name of Target Chain 26	UniProt (SwissProt) Primary ID of Target Chain 26	UniProt (SwissProt) Secondary ID(s) of Target Chain 26	UniProt (SwissProt) Alternative ID(s) of Target Chain 26	UniProt (TrEMBL) Submitted Name of Target Chain 26	UniProt (TrEMBL) Entry Name of Target Chain 26	UniProt (TrEMBL) Primary ID of Target Chain 26	UniProt (TrEMBL) Secondary ID(s) of Target Chain 26	UniProt (TrEMBL) Alternative ID(s) of Target Chain 26	BindingDB Target Chain Sequence 27	PDB ID(s) of Target Chain 27	UniProt (SwissProt) Recommended Name of Target Chain 27	UniProt (SwissProt) Entry Name of Target Chain 27	UniProt (SwissProt) Primary ID of Target Chain 27	UniProt (SwissProt) Secondary ID(s) of Target Chain 27	UniProt (SwissProt) Alternative ID(s) of Target Chain 27	UniProt (TrEMBL) Submitted Name of Target Chain 27	UniProt (TrEMBL) Entry Name of Target Chain 27	UniProt (TrEMBL) Primary ID of Target Chain 27	UniProt (TrEMBL) Secondary ID(s) of Target Chain 27	UniProt (TrEMBL) Alternative ID(s) of Target Chain 27	BindingDB Target Chain Sequence 28	PDB ID(s) of Target Chain 28	UniProt (SwissProt) Recommended Name of Target Chain 28	UniProt (SwissProt) Entry Name of Target Chain 28	UniProt (SwissProt) Primary ID of Target Chain 28	UniProt (SwissProt) Secondary ID(s) of Target Chain 28	UniProt (SwissProt) Alternative ID(s) of Target Chain 28	UniProt (TrEMBL) Submitted Name of Target Chain 28	UniProt (TrEMBL) Entry Name of Target Chain 28	UniProt (TrEMBL) Primary ID of Target Chain 28	UniProt (TrEMBL) Secondary ID(s) of Target Chain 28	UniProt (TrEMBL) Alternative ID(s) of Target Chain 28	BindingDB Target Chain Sequence 29	PDB ID(s) of Target Chain 29	UniProt (SwissProt) Recommended Name of Target Chain 29	UniProt (SwissProt) Entry Name of Target Chain 29	UniProt (SwissProt) Primary ID of Target Chain 29	UniProt (SwissProt) Secondary ID(s) of Target Chain 29	UniProt (SwissProt) Alternative ID(s) of Target Chain 29	UniProt (TrEMBL) Submitted Name of Target Chain 29	UniProt (TrEMBL) Entry Name of Target Chain 29	UniProt (TrEMBL) Primary ID of Target Chain 29	UniProt (TrEMBL) Secondary ID(s) of Target Chain 29	UniProt (TrEMBL) Alternative ID(s) of Target Chain 29	BindingDB Target Chain Sequence 30	PDB ID(s) of Target Chain 30	UniProt (SwissProt) Recommended Name of Target Chain 30	UniProt (SwissProt) Entry Name of Target Chain 30	UniProt (SwissProt) Primary ID of Target Chain 30	UniProt (SwissProt) Secondary ID(s) of Target Chain 30	UniProt (SwissProt) Alternative ID(s) of Target Chain 30	UniProt (TrEMBL) Submitted Name of Target Chain 30	UniProt (TrEMBL) Entry Name of Target Chain 30	UniProt (TrEMBL) Primary ID of Target Chain 30	UniProt (TrEMBL) Secondary ID(s) of Target Chain 30	UniProt (TrEMBL) Alternative ID(s) of Target Chain 30	BindingDB Target Chain Sequence 31	PDB ID(s) of Target Chain 31	UniProt (SwissProt) Recommended Name of Target Chain 31	UniProt (SwissProt) Entry Name of Target Chain 31	UniProt (SwissProt) Primary ID of Target Chain 31	UniProt (SwissProt) Secondary ID(s) of Target Chain 31	UniProt (SwissProt) Alternative ID(s) of Target Chain 31	UniProt (TrEMBL) Submitted Name of Target Chain 31	UniProt (TrEMBL) Entry Name of Target Chain 31	UniProt (TrEMBL) Primary ID of Target Chain 31	UniProt (TrEMBL) Secondary ID(s) of Target Chain 31	UniProt (TrEMBL) Alternative ID(s) of Target Chain 31	BindingDB Target Chain Sequence 32	PDB ID(s) of Target Chain 32	UniProt (SwissProt) Recommended Name of Target Chain 32	UniProt (SwissProt) Entry Name of Target Chain 32	UniProt (SwissProt) Primary ID of Target Chain 32	UniProt (SwissProt) Secondary ID(s) of Target Chain 32	UniProt (SwissProt) Alternative ID(s) of Target Chain 32	UniProt (TrEMBL) Submitted Name of Target Chain 32	UniProt (TrEMBL) Entry Name of Target Chain 32	UniProt (TrEMBL) Primary ID of Target Chain 32	UniProt (TrEMBL) Secondary ID(s) of Target Chain 32	UniProt (TrEMBL) Alternative ID(s) of Target Chain 32	BindingDB Target Chain Sequence 33	PDB ID(s) of Target Chain 33	UniProt (SwissProt) Recommended Name of Target Chain 33	UniProt (SwissProt) Entry Name of Target Chain 33	UniProt (SwissProt) Primary ID of Target Chain 33	UniProt (SwissProt) Secondary ID(s) of Target Chain 33	UniProt (SwissProt) Alternative ID(s) of Target Chain 33	UniProt (TrEMBL) Submitted Name of Target Chain 33	UniProt (TrEMBL) Entry Name of Target Chain 33	UniProt (TrEMBL) Primary ID of Target Chain 33	UniProt (TrEMBL) Secondary ID(s) of Target Chain 33	UniProt (TrEMBL) Alternative ID(s) of Target Chain 33	BindingDB Target Chain Sequence 34	PDB ID(s) of Target Chain 34	UniProt (SwissProt) Recommended Name of Target Chain 34	UniProt (SwissProt) Entry Name of Target Chain 34	UniProt (SwissProt) Primary ID of Target Chain 34	UniProt (SwissProt) Secondary ID(s) of Target Chain 34	UniProt (SwissProt) Alternative ID(s) of Target Chain 34	UniProt (TrEMBL) Submitted Name of Target Chain 34	UniProt (TrEMBL) Entry Name of Target Chain 34	UniProt (TrEMBL) Primary ID of Target Chain 34	UniProt (TrEMBL) Secondary ID(s) of Target Chain 34	UniProt (TrEMBL) Alternative ID(s) of Target Chain 34	BindingDB Target Chain Sequence 35	PDB ID(s) of Target Chain 35	UniProt (SwissProt) Recommended Name of Target Chain 35	UniProt (SwissProt) Entry Name of Target Chain 35	UniProt (SwissProt) Primary ID of Target Chain 35	UniProt (SwissProt) Secondary ID(s) of Target Chain 35	UniProt (SwissProt) Alternative ID(s) of Target Chain 35	UniProt (TrEMBL) Submitted Name of Target Chain 35	UniProt (TrEMBL) Entry Name of Target Chain 35	UniProt (TrEMBL) Primary ID of Target Chain 35	UniProt (TrEMBL) Secondary ID(s) of Target Chain 35	UniProt (TrEMBL) Alternative ID(s) of Target Chain 35	BindingDB Target Chain Sequence 36	PDB ID(s) of Target Chain 36	UniProt (SwissProt) Recommended Name of Target Chain 36	UniProt (SwissProt) Entry Name of Target Chain 36	UniProt (SwissProt) Primary ID of Target Chain 36	UniProt (SwissProt) Secondary ID(s) of Target Chain 36	UniProt (SwissProt) Alternative ID(s) of Target Chain 36	UniProt (TrEMBL) Submitted Name of Target Chain 36	UniProt (TrEMBL) Entry Name of Target Chain 36	UniProt (TrEMBL) Primary ID of Target Chain 36	UniProt (TrEMBL) Secondary ID(s) of Target Chain 36	UniProt (TrEMBL) Alternative ID(s) of Target Chain 36	BindingDB Target Chain Sequence 37	PDB ID(s) of Target Chain 37	UniProt (SwissProt) Recommended Name of Target Chain 37	UniProt (SwissProt) Entry Name of Target Chain 37	UniProt (SwissProt) Primary ID of Target Chain 37	UniProt (SwissProt) Secondary ID(s) of Target Chain 37	UniProt (SwissProt) Alternative ID(s) of Target Chain 37	UniProt (TrEMBL) Submitted Name of Target Chain 37	UniProt (TrEMBL) Entry Name of Target Chain 37	UniProt (TrEMBL) Primary ID of Target Chain 37	UniProt (TrEMBL) Secondary ID(s) of Target Chain 37	UniProt (TrEMBL) Alternative ID(s) of Target Chain 37	BindingDB Target Chain Sequence 38	PDB ID(s) of Target Chain 38	UniProt (SwissProt) Recommended Name of Target Chain 38	UniProt (SwissProt) Entry Name of Target Chain 38	UniProt (SwissProt) Primary ID of Target Chain 38	UniProt (SwissProt) Secondary ID(s) of Target Chain 38	UniProt (SwissProt) Alternative ID(s) of Target Chain 38	UniProt (TrEMBL) Submitted Name of Target Chain 38	UniProt (TrEMBL) Entry Name of Target Chain 38	UniProt (TrEMBL) Primary ID of Target Chain 38	UniProt (TrEMBL) Secondary ID(s) of Target Chain 38	UniProt (TrEMBL) Alternative ID(s) of Target Chain 38	BindingDB Target Chain Sequence 39	PDB ID(s) of Target Chain 39	UniProt (SwissProt) Recommended Name of Target Chain 39	UniProt (SwissProt) Entry Name of Target Chain 39	UniProt (SwissProt) Primary ID of Target Chain 39	UniProt (SwissProt) Secondary ID(s) of Target Chain 39	UniProt (SwissProt) Alternative ID(s) of Target Chain 39	UniProt (TrEMBL) Submitted Name of Target Chain 39	UniProt (TrEMBL) Entry Name of Target Chain 39	UniProt (TrEMBL) Primary ID of Target Chain 39	UniProt (TrEMBL) Secondary ID(s) of Target Chain 39	UniProt (TrEMBL) Alternative ID(s) of Target Chain 39	BindingDB Target Chain Sequence 40	PDB ID(s) of Target Chain 40	UniProt (SwissProt) Recommended Name of Target Chain 40	UniProt (SwissProt) Entry Name of Target Chain 40	UniProt (SwissProt) Primary ID of Target Chain 40	UniProt (SwissProt) Secondary ID(s) of Target Chain 40	UniProt (SwissProt) Alternative ID(s) of Target Chain 40	UniProt (TrEMBL) Submitted Name of Target Chain 40	UniProt (TrEMBL) Entry Name of Target Chain 40	UniProt (TrEMBL) Primary ID of Target Chain 40	UniProt (TrEMBL) Secondary ID(s) of Target Chain 40	UniProt (TrEMBL) Alternative ID(s) of Target Chain 40	BindingDB Target Chain Sequence 41	PDB ID(s) of Target Chain 41	UniProt (SwissProt) Recommended Name of Target Chain 41	UniProt (SwissProt) Entry Name of Target Chain 41	UniProt (SwissProt) Primary ID of Target Chain 41	UniProt (SwissProt) Secondary ID(s) of Target Chain 41	UniProt (SwissProt) Alternative ID(s) of Target Chain 41	UniProt (TrEMBL) Submitted Name of Target Chain 41	UniProt (TrEMBL) Entry Name of Target Chain 41	UniProt (TrEMBL) Primary ID of Target Chain 41	UniProt (TrEMBL) Secondary ID(s) of Target Chain 41	UniProt (TrEMBL) Alternative ID(s) of Target Chain 41	BindingDB Target Chain Sequence 42	PDB ID(s) of Target Chain 42	UniProt (SwissProt) Recommended Name of Target Chain 42	UniProt (SwissProt) Entry Name of Target Chain 42	UniProt (SwissProt) Primary ID of Target Chain 42	UniProt (SwissProt) Secondary ID(s) of Target Chain 42	UniProt (SwissProt) Alternative ID(s) of Target Chain 42	UniProt (TrEMBL) Submitted Name of Target Chain 42	UniProt (TrEMBL) Entry Name of Target Chain 42	UniProt (TrEMBL) Primary ID of Target Chain 42	UniProt (TrEMBL) Secondary ID(s) of Target Chain 42	UniProt (TrEMBL) Alternative ID(s) of Target Chain 42	BindingDB Target Chain Sequence 43	PDB ID(s) of Target Chain 43	UniProt (SwissProt) Recommended Name of Target Chain 43	UniProt (SwissProt) Entry Name of Target Chain 43	UniProt (SwissProt) Primary ID of Target Chain 43	UniProt (SwissProt) Secondary ID(s) of Target Chain 43	UniProt (SwissProt) Alternative ID(s) of Target Chain 43	UniProt (TrEMBL) Submitted Name of Target Chain 43	UniProt (TrEMBL) Entry Name of Target Chain 43	UniProt (TrEMBL) Primary ID of Target Chain 43	UniProt (TrEMBL) Secondary ID(s) of Target Chain 43	UniProt (TrEMBL) Alternative ID(s) of Target Chain 43	BindingDB Target Chain Sequence 44	PDB ID(s) of Target Chain 44	UniProt (SwissProt) Recommended Name of Target Chain 44	UniProt (SwissProt) Entry Name of Target Chain 44	UniProt (SwissProt) Primary ID of Target Chain 44	UniProt (SwissProt) Secondary ID(s) of Target Chain 44	UniProt (SwissProt) Alternative ID(s) of Target Chain 44	UniProt (TrEMBL) Submitted Name of Target Chain 44	UniProt (TrEMBL) Entry Name of Target Chain 44	UniProt (TrEMBL) Primary ID of Target Chain 44	UniProt (TrEMBL) Secondary ID(s) of Target Chain 44	UniProt (TrEMBL) Alternative ID(s) of Target Chain 44	BindingDB Target Chain Sequence 45	PDB ID(s) of Target Chain 45	UniProt (SwissProt) Recommended Name of Target Chain 45	UniProt (SwissProt) Entry Name of Target Chain 45	UniProt (SwissProt) Primary ID of Target Chain 45	UniProt (SwissProt) Secondary ID(s) of Target Chain 45	UniProt (SwissProt) Alternative ID(s) of Target Chain 45	UniProt (TrEMBL) Submitted Name of Target Chain 45	UniProt (TrEMBL) Entry Name of Target Chain 45	UniProt (TrEMBL) Primary ID of Target Chain 45	UniProt (TrEMBL) Secondary ID(s) of Target Chain 45	UniProt (TrEMBL) Alternative ID(s) of Target Chain 45	BindingDB Target Chain Sequence 46	PDB ID(s) of Target Chain 46	UniProt (SwissProt) Recommended Name of Target Chain 46	UniProt (SwissProt) Entry Name of Target Chain 46	UniProt (SwissProt) Primary ID of Target Chain 46	UniProt (SwissProt) Secondary ID(s) of Target Chain 46	UniProt (SwissProt) Alternative ID(s) of Target Chain 46	UniProt (TrEMBL) Submitted Name of Target Chain 46	UniProt (TrEMBL) Entry Name of Target Chain 46	UniProt (TrEMBL) Primary ID of Target Chain 46	UniProt (TrEMBL) Secondary ID(s) of Target Chain 46	UniProt (TrEMBL) Alternative ID(s) of Target Chain 46	BindingDB Target Chain Sequence 47	PDB ID(s) of Target Chain 47	UniProt (SwissProt) Recommended Name of Target Chain 47	UniProt (SwissProt) Entry Name of Target Chain 47	UniProt (SwissProt) Primary ID of Target Chain 47	UniProt (SwissProt) Secondary ID(s) of Target Chain 47	UniProt (SwissProt) Alternative ID(s) of Target Chain 47	UniProt (TrEMBL) Submitted Name of Target Chain 47	UniProt (TrEMBL) Entry Name of Target Chain 47	UniProt (TrEMBL) Primary ID of Target Chain 47	UniProt (TrEMBL) Secondary ID(s) of Target Chain 47	UniProt (TrEMBL) Alternative ID(s) of Target Chain 47	BindingDB Target Chain Sequence 48	PDB ID(s) of Target Chain 48	UniProt (SwissProt) Recommended Name of Target Chain 48	UniProt (SwissProt) Entry Name of Target Chain 48	UniProt (SwissProt) Primary ID of Target Chain 48	UniProt (SwissProt) Secondary ID(s) of Target Chain 48	UniProt (SwissProt) Alternative ID(s) of Target Chain 48	UniProt (TrEMBL) Submitted Name of Target Chain 48	UniProt (TrEMBL) Entry Name of Target Chain 48	UniProt (TrEMBL) Primary ID of Target Chain 48	UniProt (TrEMBL) Secondary ID(s) of Target Chain 48	UniProt (TrEMBL) Alternative ID(s) of Target Chain 48	BindingDB Target Chain Sequence 49	PDB ID(s) of Target Chain 49	UniProt (SwissProt) Recommended Name of Target Chain 49	UniProt (SwissProt) Entry Name of Target Chain 49	UniProt (SwissProt) Primary ID of Target Chain 49	UniProt (SwissProt) Secondary ID(s) of Target Chain 49	UniProt (SwissProt) Alternative ID(s) of Target Chain 49	UniProt (TrEMBL) Submitted Name of Target Chain 49	UniProt (TrEMBL) Entry Name of Target Chain 49	UniProt (TrEMBL) Primary ID of Target Chain 49	UniProt (TrEMBL) Secondary ID(s) of Target Chain 49	UniProt (TrEMBL) Alternative ID(s) of Target Chain 49	BindingDB Target Chain Sequence 50	PDB ID(s) of Target Chain 50	UniProt (SwissProt) Recommended Name of Target Chain 50	UniProt (SwissProt) Entry Name of Target Chain 50	UniProt (SwissProt) Primary ID of Target Chain 50	UniProt (SwissProt) Secondary ID(s) of Target Chain 50	UniProt (SwissProt) Alternative ID(s) of Target Chain 50	UniProt (TrEMBL) Submitted Name of Target Chain 50	UniProt (TrEMBL) Entry Name of Target Chain 50	UniProt (TrEMBL) Primary ID of Target Chain 50	UniProt (TrEMBL) Secondary ID(s) of Target Chain 50	UniProt (TrEMBL) Alternative ID(s) of Target Chain 50
238320	CC1Nc2ccc3ncc(n3n2)-c2cc(ccn2)COc2ccc(F)cc21	InChI=1S/C20H16FN5O/c1-12-15-9-14(21)2-3-18(15)27-11-13-6-7-22-16(8-13)17-10-23-20-5-4-19(24-12)25-26(17)20/h2-10,12H,11H2,1H3,(H,24,25)	ORCBEAXRXVSMKD-UHFFFAOYSA-N	540249	(E)-5-fluoro-6-methyl-4-oxa-7-aza-1-imidazo[1,2-b]pyridazine-2-pyridine-5-benzenacycloheptaphane::US20260028352, Example I-1	High affinity nerve growth factor receptor	Homo sapiens		 2.57							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540249	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540249&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121447050	464925235							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238321	CC1Nc2ccc3ncc(n3n2)-c2cc(ccn2)COc2c(F)cc(F)cc21	InChI=1S/C20H15F2N5O/c1-11-14-7-13(21)8-15(22)20(14)28-10-12-4-5-23-16(6-12)17-9-24-19-3-2-18(25-11)26-27(17)19/h2-9,11H,10H2,1H3,(H,25,26)	GVUUYSHGOSPJRA-UHFFFAOYSA-N	540250	(E)-5,5'-difluoro-6-methyl-4-oxa-7-aza-1(3,6)-imidazo[1,2-b]pyridazine-2(2,4)-pyridina-5(1,2)-benzenacycloheptaphane::US20260028352, Example I-2	High affinity nerve growth factor receptor	Homo sapiens		 2.59							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540250	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540250&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121447054	464925236							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238322	CC1Nc2ccc3ncc(n3n2)-c2cc(ccn2)COc2ccccc21	InChI=1S/C20H17N5O/c1-13-15-4-2-3-5-18(15)26-12-14-8-9-21-16(10-14)17-11-22-20-7-6-19(23-13)24-25(17)20/h2-11,13H,12H2,1H3,(H,23,24)	AAGFEFPZUYTMTD-UHFFFAOYSA-N	540251	(E)-6-methyl-4-oxa-7-aza-1(3,6)-imidazo[1,2-b]pyridazine-2(2,4)-pyridine-5(1,2)-benzenacycloheptaphane::US20260028352, Example I-3	High affinity nerve growth factor receptor	Homo sapiens		 5.90							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540251	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540251&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121447053	464925237							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238323	CC1Nc2ccc3ncc(n3n2)-c2cc(ccn2)COc2ccc(F)cc21	InChI=1S/C20H16FN5O/c1-12-15-9-14(21)2-3-18(15)27-11-13-6-7-22-16(8-13)17-10-23-20-5-4-19(24-12)25-26(17)20/h2-10,12H,11H2,1H3,(H,24,25)	ORCBEAXRXVSMKD-UHFFFAOYSA-N	540252	(E)-6-methyl-4-oxa-7-aza-1(3,6)-imidazo[1,2-b]pyridazina-2(2,4), 5(2,3)-dipyridinacycloheptaphane::US20260028352, Example I-4	High affinity nerve growth factor receptor	Homo sapiens		<3.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540252	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540252&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121446958	464925238							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238324	CC1Nc2ccc3ncc(n3n2)-c2cc(ccn2)COc2ncc(F)cc21	InChI=1S/C19H15FN6O/c1-11-14-7-13(20)8-23-19(14)27-10-12-4-5-21-15(6-12)16-9-22-18-3-2-17(24-11)25-26(16)18/h2-9,11H,10H2,1H3,(H,24,25)	ASCFZLSPYXOWEP-UHFFFAOYSA-N	540253	(E)-54-fluoro-4-oxa-7-aza-1(3,6)-imidazo[1,2-b]pyridazina-2(2,4)-pyridina-5(1,2)-benzenacycloheptaphane::US20260028352, Example I-5	High affinity nerve growth factor receptor	Homo sapiens		 1.36							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540253	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540253&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121447304	464925239							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238325	c1ccc2c(c1)CNc1ccc3ncc(n3n1)-c1cc(ccn1)CO2	InChI=1S/C19H15N5O/c1-2-4-17-14(3-1)10-21-18-5-6-19-22-11-16(24(19)23-18)15-9-13(12-25-17)7-8-20-15/h1-9,11H,10,12H2,(H,21,23)	KVTHKOQHNQCJDK-UHFFFAOYSA-N	540254	(E)-4-oxa-7-aza-1(3,6)-imidazo[1,2-b]pyridazina-2(2,4)-pyridina-5(1,2)-benzenacycloheptaphane::US20260028352, Example I-6	High affinity nerve growth factor receptor	Homo sapiens		 2.76							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540254	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540254&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121447424	464925240							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238326	CC1Nc2ccc3ncc(n3n2)-c2cncc(c2)COc2ccc(F)cc21	InChI=1S/C20H16FN5O/c1-12-16-7-15(21)2-3-18(16)27-11-13-6-14(9-22-8-13)17-10-23-20-5-4-19(24-12)25-26(17)20/h2-10,12H,11H2,1H3,(H,24,25)	FQNFJPNSYVWSLJ-UHFFFAOYSA-N	540255	(E)-54-fluoro-6-methyl-4-oxa-7-aza-1(3,6)-imidazo[1,2-b]pyridazine-2(3,5)-pyridina-5(1,2)-benzenacycloheptaphane::US20260028352, Example I-7	High affinity nerve growth factor receptor	Homo sapiens		<3.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540255	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540255&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121447253	464925241							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238327	c1ccc2c(c1)CNc1ccc3ncc(n3n1)-c1cncc(c1)CCO2	InChI=1S/C20H17N5O/c1-2-4-18-15(3-1)12-22-19-5-6-20-23-13-17(25(20)24-19)16-9-14(7-8-26-18)10-21-11-16/h1-6,9-11,13H,7-8,12H2,(H,22,24)	VLEUZBIYEHGRBZ-UHFFFAOYSA-N	540256	(E)-6-oxa-3-aza-2(3,6)-imidazo[1,2-b]pyridazina-1(2,4)-pyridina-5(1,2)-benzenacyclooctaphane::US20260028352, Example I-8	High affinity nerve growth factor receptor	Homo sapiens		 2.46							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540256	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540256&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121446959	464925242							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238328	CC1Nc2ccc3ncc(n3n2)-c2cc(ccn2)CCOc2ccccc21	InChI=1S/C21H19N5O/c1-14-16-4-2-3-5-19(16)27-11-9-15-8-10-22-17(12-15)18-13-23-21-7-6-20(24-14)25-26(18)21/h2-8,10,12-14H,9,11H2,1H3,(H,24,25)	YZTPKLFQYJZQOU-UHFFFAOYSA-N	540257	(E)-4-methyl-6-oxa-3-aza-2(3,6)-imidazo[1,2-b]pyridazina-1(2,4)-pyridina-5(1,2)-benzenacyclooctaphane::US20260028352, Example I-9	High affinity nerve growth factor receptor	Homo sapiens		<3.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540257	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540257&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121446957	464925243							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238329	CC1Nc2ccc3ncc(n3n2)-c2cc(ncn2)COc2ccccc21	InChI=1S/C19H16N6O/c1-12-14-4-2-3-5-17(14)26-10-13-8-15(22-11-21-13)16-9-20-19-7-6-18(23-12)24-25(16)19/h2-9,11-12H,10H2,1H3,(H,23,24)	MNFCCBRZQYYMNF-UHFFFAOYSA-N	540258	(E)-6-methyl-4-oxa-7-aza-1(3,6)-imidazo[1,2-b]pyridazina-2(4,6)-pyrimidine-5(1,2)-benzenacycloheptaphane::US20260028352, Example I-10	High affinity nerve growth factor receptor	Homo sapiens		<3.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540258	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540258&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121447057	464925244							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238330	CC1Nc2ccc3ncc(n3n2)-c2cc(ncn2)CCOc2ccccc21	InChI=1S/C20H18N6O/c1-13-15-4-2-3-5-18(15)27-9-8-14-10-16(23-12-22-14)17-11-21-20-7-6-19(24-13)25-26(17)20/h2-7,10-13H,8-9H2,1H3,(H,24,25)	FATCNTFSENHZBG-UHFFFAOYSA-N	540259	(E)-4-methyl-6-oxa-3-aza-2(3,6)-imidazo[1,2-b]pyridazina-1(4,6)-pyrimidina-5(1,2)-benzenacycloheptaphane::US20260028352, Example I-11	High affinity nerve growth factor receptor	Homo sapiens		<3.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540259	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540259&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121447254	464925245							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238331	CC1Nc2ccc3ncc(n3n2)-c2cc(ccn2)OCc2ncc(F)cc21	InChI=1S/C19H15FN6O/c1-11-14-6-12(20)8-22-16(14)10-27-13-4-5-21-15(7-13)17-9-23-19-3-2-18(24-11)25-26(17)19/h2-9,11H,10H2,1H3,(H,24,25)	WJVMOPOTVOGGPM-UHFFFAOYSA-N	540260	(E)-55-fluoro-6-methyl-3-oxa-7-aza-1(3,6)-imidazo[1,2-b]pyridazina-2(2,4), 5(2,3)-dipyridinacycloheptaphane::US20260028352, Example I-12	High affinity nerve growth factor receptor	Homo sapiens		<3.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540260	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540260&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121447430	464925246							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238332	CC1Nc2ccc3ncc(n3n2)-c2cc(ccn2)OCc2ccc(F)cc21	InChI=1S/C20H16FN5O/c1-12-16-8-14(21)3-2-13(16)11-27-15-6-7-22-17(9-15)18-10-23-20-5-4-19(24-12)25-26(18)20/h2-10,12H,11H2,1H3,(H,24,25)	KLVQBCTUSSQNFS-UHFFFAOYSA-N	540261	(E)-54-fluoro-6-methyl-3-oxa-7-aza-1(3,6)-imidazo[1,2-b]pyridazina-2(2,4)-pyridina-5(1,2)-benzenacycloheptaphane::US20260028352, Example I-13	High affinity nerve growth factor receptor	Homo sapiens		<3.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540261	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540261&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121446960	464925247							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238333	C[C@H]1Nc2ccc3ncc(n3n2)-c2cc(ccn2)COc2ccc(F)cc21	InChI=1S/C20H16FN5O/c1-12-15-9-14(21)2-3-18(15)27-11-13-6-7-22-16(8-13)17-10-23-20-5-4-19(24-12)25-26(17)20/h2-10,12H,11H2,1H3,(H,24,25)	ORCBEAXRXVSMKD-UHFFFAOYSA-N	540262	(R)-(E)-54-fluoro-6-methyl-4-oxa-7-aza-1(3,6)-imidazo[1,2-b]pyridazina-2(2,4)-pyridina-5(1,2)-benzenacycloheptaphane::US20260028352, Example I-14	High affinity nerve growth factor receptor	Homo sapiens		<3.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540262	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540262&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121447429	464925248							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238334	C[C@@H]1Nc2ccc3ncc(n3n2)-c2cc(ccn2)COc2ccc(F)cc21	InChI=1S/C20H16FN5O/c1-12-15-9-14(21)2-3-18(15)27-11-13-6-7-22-16(8-13)17-10-23-20-5-4-19(24-12)25-26(17)20/h2-10,12H,11H2,1H3,(H,24,25)	ORCBEAXRXVSMKD-UHFFFAOYSA-N	540263	(S)-(E)-5'-fluoro-6-methyl-4-oxa-7-aza-1(3,6)-imidazo[1,2-b]pyridazina-2(2,4)-pyridina-5(1,2)-benzenacycloheptaphane::US20260028352, Example I-15	High affinity nerve growth factor receptor	Homo sapiens		 4.80							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540263	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540263&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121447059	464925249							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238335	C[C@H]1Nc2ccc3ncc(n3n2)-c2cc(ccn2)COc2c(F)cc(F)cc21	InChI=1S/C20H15F2N5O/c1-11-14-7-13(21)8-15(22)20(14)28-10-12-4-5-23-16(6-12)17-9-24-19-3-2-18(25-11)26-27(17)19/h2-9,11H,10H2,1H3,(H,25,26)	GVUUYSHGOSPJRA-UHFFFAOYSA-N	540264	(R)-(E)-54,56-difluoro-6-methyl-4-oxa-7-aza-1(3,6)-imidazo[1,2-b]pyridazine-2(2,4)-pyridina-5(1,2)-benzenacycloheptaphane::US20260028352, Example I-16	High affinity nerve growth factor receptor	Homo sapiens		<3.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540264	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540264&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121447289	464925250							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238336	C[C@@H]1Nc2ccc3ncc(n3n2)-c2cc(ccn2)COc2c(F)cc(F)cc21	InChI=1S/C20H15F2N5O/c1-11-14-7-13(21)8-15(22)20(14)28-10-12-4-5-23-16(6-12)17-9-24-19-3-2-18(25-11)26-27(17)19/h2-9,11H,10H2,1H3,(H,25,26)	GVUUYSHGOSPJRA-UHFFFAOYSA-N	540265	(S)-(E)-5',5'-difluoro-6-methyl-4-oxa-7-aza-1(3,6)-imidazo[1,2-b]pyridazine-2(2,4)-pyridina-5(1,2)-benzenacycloheptaphane::US20260028352, Example I-17	High affinity nerve growth factor receptor	Homo sapiens		 5.20							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540265	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540265&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121447196	464925251							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238337	C[C@H]1Nc2ccc3ncc(n3n2)-c2cc(ccn2)COc2ccccc21	InChI=1S/C20H17N5O/c1-13-15-4-2-3-5-18(15)26-12-14-8-9-21-16(10-14)17-11-22-20-7-6-19(23-13)24-25(17)20/h2-11,13H,12H2,1H3,(H,23,24)	AAGFEFPZUYTMTD-UHFFFAOYSA-N	540266	(R)-(E)-6-methyl-4-oxa-7-aza-1(3,6)-imidazo[1,2-b]pyridazine-2(2,4)-pyridina-5(1,2)-benzenacycloheptaphane::US20260028352, Example I-18	High affinity nerve growth factor receptor	Homo sapiens		<3.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540266	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540266&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121447248	464925252							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238338	C[C@@H]1Nc2ccc3ncc(n3n2)-c2cc(ccn2)COc2ccccc21	InChI=1S/C20H17N5O/c1-13-15-4-2-3-5-18(15)26-12-14-8-9-21-16(10-14)17-11-22-20-7-6-19(23-13)24-25(17)20/h2-11,13H,12H2,1H3,(H,23,24)	AAGFEFPZUYTMTD-UHFFFAOYSA-N	540267	(S)-(E)-6-methyl-4-oxa-7-aza-1(3,6)-imidazo[1,2-b]pyridazine-2(2,4)-pyridina-5(1,2)-benzenacycloheptaphane::US20260028352, Example I-19	High affinity nerve growth factor receptor	Homo sapiens		 5.70							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540267	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540267&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121447200	464925253							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238339	C[C@H]1Nc2ccc3ncc(n3n2)-c2cc(ccn2)COc2ncccc21	InChI=1S/C19H16N6O/c1-12-14-3-2-7-21-19(14)26-11-13-6-8-20-15(9-13)16-10-22-18-5-4-17(23-12)24-25(16)18/h2-10,12H,11H2,1H3,(H,23,24)	SVCHIYVESLEUMG-UHFFFAOYSA-N	540268	(R)-(E)-6-methyl-4-oxa-7-aza-1(3,6)-imidazo[1,2-b]pyridazina-2(2,4), 5(2,3)-dipyridinacycloheptaphane::US20260028352, Example I-20	High affinity nerve growth factor receptor	Homo sapiens		<3.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540268	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540268&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121447434	464925254							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238340	C[C@@H]1Nc2ccc3ncc(n3n2)-c2cc(ccn2)COc2ncccc21	InChI=1S/C19H16N6O/c1-12-14-3-2-7-21-19(14)26-11-13-6-8-20-15(9-13)16-10-22-18-5-4-17(23-12)24-25(16)18/h2-10,12H,11H2,1H3,(H,23,24)	SVCHIYVESLEUMG-UHFFFAOYSA-N	540269	(6S,E)-6-methyl-4-oxa-7-aza-1(3,6)-imidazo[1,2-b]pyridazina-2(2,4), 5(2,3)-dipyridinacycloheptaphane::US20260028352, Example I-21	High affinity nerve growth factor receptor	Homo sapiens		 6.10							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540269	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540269&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121447218	464925255							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238341	C[C@H]1Nc2ccc3ncc(n3n2)-c2cncc(c2)COc2ccc(F)cc21	InChI=1S/C20H16FN5O/c1-12-16-7-15(21)2-3-18(16)27-11-13-6-14(9-22-8-13)17-10-23-20-5-4-19(24-12)25-26(17)20/h2-10,12H,11H2,1H3,(H,24,25)	FQNFJPNSYVWSLJ-UHFFFAOYSA-N	540270	(R)-(E)-54-fluoro-6-methyl-4-oxa-7-aza-1(3,6)-imidazo[1,2-b]pyridazina-2(3,5)-pyridina-5(1,2)-benzenacycloheptaphane::US20260028352, Example I-22	High affinity nerve growth factor receptor	Homo sapiens		<3.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540270	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540270&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121447201	464925256							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238342	C[C@@H]1Nc2ccc3ncc(n3n2)-c2cncc(c2)COc2ccc(F)cc21	InChI=1S/C20H16FN5O/c1-12-16-7-15(21)2-3-18(16)27-11-13-6-14(9-22-8-13)17-10-23-20-5-4-19(24-12)25-26(17)20/h2-10,12H,11H2,1H3,(H,24,25)	FQNFJPNSYVWSLJ-UHFFFAOYSA-N	540271	(S)-(E)-54-fluoro-6-methyl-4-oxa-7-aza-1(3,6)-imidazo[1,2-b]pyridazina-2(3,5)-pyridina-5(1,2)-benzenacycloheptaphane::US20260028352, Example I-23	High affinity nerve growth factor receptor	Homo sapiens		 4.80							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540271	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540271&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121446962	464925257							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238343	C[C@@H]1Nc2ccc3ncc(n3n2)-c2cncc(c2)OCc2ncc(F)cc21	InChI=1S/C19H15FN6O/c1-11-15-5-13(20)7-22-16(15)10-27-14-4-12(6-21-8-14)17-9-23-19-3-2-18(24-11)25-26(17)19/h2-9,11H,10H2,1H3,(H,24,25)	ACRQYMGHQSIJOJ-UHFFFAOYSA-N	540272	(R)-(E)-55-fluoro-6-methyl-3-oxa-7-aza-1(3,6)-imidazo[1,2-b]pyridazina-2(2,4), 5(2,3)-dipyridinacycloheptaphane::US20260028352, Example I-24	High affinity nerve growth factor receptor	Homo sapiens		<3.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540272	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540272&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121447302	464925258							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238344	C[C@H]1Nc2ccc3ncc(n3n2)-c2cncc(c2)OCc2ncc(F)cc21	InChI=1S/C19H15FN6O/c1-11-15-5-13(20)7-22-16(15)10-27-14-4-12(6-21-8-14)17-9-23-19-3-2-18(24-11)25-26(17)19/h2-9,11H,10H2,1H3,(H,24,25)	ACRQYMGHQSIJOJ-UHFFFAOYSA-N	540273	(S)-(E)-55-fluoro-6-methyl-3-oxa-7-aza-1(3,6)-imidazo[1,2-b]pyridazina-2(2,4), 5(2,3)-dipyridinacycloheptaphane::US20260028352, Example I-25	High affinity nerve growth factor receptor	Homo sapiens		 5.10							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540273	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540273&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121447250	464925259							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238345	C[C@H]1Nc2ccc3ncc(n3n2)-c2cc(ncn2)COc2ccccc21	InChI=1S/C19H16N6O/c1-12-14-4-2-3-5-17(14)26-10-13-8-15(22-11-21-13)16-9-20-19-7-6-18(23-12)24-25(16)19/h2-9,11-12H,10H2,1H3,(H,23,24)	MNFCCBRZQYYMNF-UHFFFAOYSA-N	540274	(R)-(E)-6-methyl-4-oxa-7-aza-1(3,6)-imidazo[1,2-b]pyridazina-2(4,6)-pyrimidina-5(1,2)-benzenacycloheptaphane::US20260028352, Example I-26	High affinity nerve growth factor receptor	Homo sapiens		<3.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540274	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540274&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121446963	464925260							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238346	C[C@@H]1Nc2ccc3ncc(n3n2)-c2cc(ncn2)COc2ccccc21	InChI=1S/C19H16N6O/c1-12-14-4-2-3-5-17(14)26-10-13-8-15(22-11-21-13)16-9-20-19-7-6-18(23-12)24-25(16)19/h2-9,11-12H,10H2,1H3,(H,23,24)	MNFCCBRZQYYMNF-UHFFFAOYSA-N	540275	(6S,E)-6-methyl-4-oxa-7-aza-1(3,6)-imidazo[1,2-b]pyridazina-2(4,6)-pyrimidina-5(1,2)-benzenacycloheptaphane::US20260028352, Example I-27	High affinity nerve growth factor receptor	Homo sapiens		 3.70							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540275	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540275&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121447307	464925261							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238347	C[C@@H]1Nc2ccc3ncc(n3n2)-c2cc(ccn2)CCOc2ccc(F)cc21	InChI=1S/C21H18FN5O/c1-13-16-11-15(22)2-3-19(16)28-9-7-14-6-8-23-17(10-14)18-12-24-21-5-4-20(25-13)26-27(18)21/h2-6,8,10-13H,7,9H2,1H3,(H,25,26)	XZENVYVAUNFWEK-UHFFFAOYSA-N	540276	(4R,E)-4-methyl-6-oxa-3-aza-2(3,6)-imidazo[1,2-b]pyridazina-1(2,4)-pyridina-5(1,2)-benzenacyclooctaphane::US20260028352, Example I-28	High affinity nerve growth factor receptor	Homo sapiens		<3.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540276	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540276&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121447199	464925262							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238348	C[C@H]1Nc2ccc3ncc(n3n2)-c2cc(ccn2)CCOc2ccc(F)cc21	InChI=1S/C21H18FN5O/c1-13-16-11-15(22)2-3-19(16)28-9-7-14-6-8-23-17(10-14)18-12-24-21-5-4-20(25-13)26-27(18)21/h2-6,8,10-13H,7,9H2,1H3,(H,25,26)	XZENVYVAUNFWEK-UHFFFAOYSA-N	540277	(4S,E)-4-methyl-6-oxa-3-aza-2(3,6)-imidazo [1,2-b]pyridazina-1(2,4)-pyridina-5(1,2)-benzenacyclooctaphane::US20260028352, Example I-29	High affinity nerve growth factor receptor	Homo sapiens		 4.90							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540277	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540277&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121447269	464925263							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238349	C[C@H]1Nc2ccc3ncc(n3n2)-c2cc(ccn2)OCc2ccc(F)cc21	InChI=1S/C20H16FN5O/c1-12-16-8-14(21)3-2-13(16)11-27-15-6-7-22-17(9-15)18-10-23-20-5-4-19(24-12)25-26(18)20/h2-10,12H,11H2,1H3,(H,24,25)	KLVQBCTUSSQNFS-UHFFFAOYSA-N	540278	(R)-(E)-54-fluoro-6-methyl-3-oxa-7-aza-1(3,6)-imidazo[1,2-b]pyridazina-2(2,4)-pyridina-5(1,2)-benzenacycloheptaphane::US20260028352, Example I-30	High affinity nerve growth factor receptor	Homo sapiens		<3.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540278	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540278&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121447313	464925264							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238350	C[C@@H]1Nc2ccc3ncc(n3n2)-c2cc(ccn2)OCc2ccc(F)cc21	InChI=1S/C20H16FN5O/c1-12-16-8-14(21)3-2-13(16)11-27-15-6-7-22-17(9-15)18-10-23-20-5-4-19(24-12)25-26(18)20/h2-10,12H,11H2,1H3,(H,24,25)	KLVQBCTUSSQNFS-UHFFFAOYSA-N	540279	(S)-(E)-54-fluoro-6-methyl-3-oxa-7-aza-1(3,6)-imidazo[1,2-b]pyridazina-2(2,4)-pyridina-5(1,2)-benzenacycloheptaphane::US20260028352, Example I-31	High affinity nerve growth factor receptor	Homo sapiens		 5.70							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540279	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540279&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121447276	464925265							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238351	C[C@H]1Nc2ccc3ncc(n3n2)-c2cc(ncn2)CCOc2ccccc21	InChI=1S/C20H18N6O/c1-13-15-4-2-3-5-18(15)27-9-8-14-10-16(23-12-22-14)17-11-21-20-7-6-19(24-13)25-26(17)20/h2-7,10-13H,8-9H2,1H3,(H,24,25)	FATCNTFSENHZBG-UHFFFAOYSA-N	540280	(R)-(E)-4-methyl-6-oxa-3-aza-2(3,6)-imidazo[1,2-b]pyridazina-1(4,6)-pyrimidina-5(1,2)-benzenacyclooctaphane::US20260028352, Example I-32	High affinity nerve growth factor receptor	Homo sapiens		<3.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540280	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540280&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121446964	464925266							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238352	C[C@@H]1Nc2ccc3ncc(n3n2)-c2cc(ncn2)CCOc2ccccc21	InChI=1S/C20H18N6O/c1-13-15-4-2-3-5-18(15)27-9-8-14-10-16(23-12-22-14)17-11-21-20-7-6-19(24-13)25-26(17)20/h2-7,10-13H,8-9H2,1H3,(H,24,25)	FATCNTFSENHZBG-UHFFFAOYSA-N	540281	(R)-(E)-4-methyl-6-oxa-3-aza-2(3,6)-imidazo[1,2-b]pyridazina-1(4,6)-pyrimidina-5(1,2)-benzenacyclooctaphane::US20260028352, Example I-33	High affinity nerve growth factor receptor	Homo sapiens		 5.90							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540281	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540281&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121447336	464925267							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238353	C[C@@H]1Cc2ccnc(c2)-c2cnc3ccc(nn23)N[C@H](C)c2cc(F)ccc2O1	InChI=1S/C22H20FN5O/c1-13-9-15-7-8-24-18(10-15)19-12-25-22-6-5-21(27-28(19)22)26-14(2)17-11-16(23)3-4-20(17)29-13/h3-8,10-14H,9H2,1-2H3,(H,26,27)	UHDLVVDUXWRCMH-UHFFFAOYSA-N	540282	(4R,7R,E)-55-fluoro-4,7-dimethyl-6-oxa-3-aza-2(3,6)-imidazo[1,2-b]pyridazina-1(2,4)-pyridina-5(1,2)-benzenacyclooctaphane::US20260028352, Example I-34	High affinity nerve growth factor receptor	Homo sapiens		<3.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540282	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540282&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121446965	464925268							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238354	C[C@@H]1Cc2cc(ncn2)-c2cnc3ccc(nn23)N[C@H](C)c2cc(F)ccc2O1	InChI=1S/C21H19FN6O/c1-12-7-15-9-17(25-11-24-15)18-10-23-21-6-5-20(27-28(18)21)26-13(2)16-8-14(22)3-4-19(16)29-12/h3-6,8-13H,7H2,1-2H3,(H,26,27)	ITZDIEFBIHYMSJ-UHFFFAOYSA-N	540283	(4R,7R,E)-5'-fluoro-4,7-dimethyl-6-oxa-3-aza-2(3,6)-imidazo[1,2-b]pyridazina-1(4,6)-pyrimidina-5(1,2)-benzenacyclooctaphane::US20260028352, Example I-35	High affinity nerve growth factor receptor	Homo sapiens		<3.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540283	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540283&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121447439	464925269							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238355	C[C@@H]1Cc2ccnc(c2)-c2cnc3ccc(nn23)N[C@H](C)c2cc(F)cnc2O1	InChI=1S/C21H19FN6O/c1-12-7-14-5-6-23-17(8-14)18-11-24-20-4-3-19(27-28(18)20)26-13(2)16-9-15(22)10-25-21(16)29-12/h3-6,8-13H,7H2,1-2H3,(H,26,27)	ZEWWIZIZHRADBR-UHFFFAOYSA-N	540284	(4R,7R,E)-55-fluoro-4,7-dimethyl-6-oxa-3-aza-2(3,6)-imidazo[1,2-b]pyridazina-1(2,4), 5(3,2)-dipyridinacyclooctaphane::US20260028352, Example I-36	High affinity nerve growth factor receptor	Homo sapiens		<3.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540284	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540284&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121447290	464925270							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238356	C[C@@H]1Cc2ccnc(c2)-c2cnc3ccc(nn23)N2CCC[C@@H]2c2cc(F)ccc2O1	InChI=1S/C24H22FN5O/c1-15-11-16-8-9-26-19(12-16)21-14-27-23-6-7-24(28-30(21)23)29-10-2-3-20(29)18-13-17(25)4-5-22(18)31-15/h4-9,12-15,20H,2-3,10-11H2,1H3	KTUQXYOQECBWRJ-UHFFFAOYSA-N	540285	(32R,6R,E)-45-fluoro-6-methyl-5-oxa-2(3,6)-imidazo[1,2-b]pyridazina-1(2,4)-pyridina-3(1,2)-pyrrolidina-4(1,2)-benzenacycloheptaphane::US20260028352, Example I-37	High affinity nerve growth factor receptor	Homo sapiens		<3.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540285	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540285&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121447440	464925271							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238357	C[C@@H]1Cc2ccnc(c2)-c2cnc3ccc(nn23)N2CCC[C@@H]2c2cc(F)cnc2O1	InChI=1S/C23H21FN6O/c1-14-9-15-6-7-25-18(10-15)20-13-26-21-4-5-22(28-30(20)21)29-8-2-3-19(29)17-11-16(24)12-27-23(17)31-14/h4-7,10-14,19H,2-3,8-9H2,1H3	WFEOFAMMFORTDR-UHFFFAOYSA-N	540286	(32R,6R,E)-45-fluoro-6-methyl-5-oxa-2(3,6)-imidazo[1,2-b]pyridazina-1(2,4), 4(3,2)-dipyridina-3(1,2)-pyrrolidinacycloheptaphane::US20260028352, Example I-38	High affinity nerve growth factor receptor	Homo sapiens		<3.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540286	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540286&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121447299	464925272							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238358	C[C@@H]1Cc2ccnc(c2)-c2cnc3ccc(nn23)N2C[C@@H](F)C[C@@H]2c2cc(F)ccc2O1	InChI=1S/C24H21F2N5O/c1-14-8-15-6-7-27-19(9-15)21-12-28-23-4-5-24(29-31(21)23)30-13-17(26)11-20(30)18-10-16(25)2-3-22(18)32-14/h2-7,9-10,12,14,17,20H,8,11,13H2,1H3	KWCGFNKHVWGYAC-UHFFFAOYSA-N	540287	(32R,34S,6R,E)-34,45-difluoro-6-methyl-5-oxa-2(3,6)-imidazo[1,2-b]pyridazina-1(2,4)-pyridina-3(1,2)-pyrrolidina-4(1,2)-benzenacycloheptaphane::US20260028352, Example I-39	High affinity nerve growth factor receptor	Homo sapiens		<3.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540287	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540287&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121447204	464925273							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238359	C[C@@H]1Cc2ccnc(c2)-c2cnc3ccc(nn23)N2C[C@@H](F)C[C@@H]2c2cc(F)cnc2O1	InChI=1S/C23H20F2N6O/c1-13-6-14-4-5-26-18(7-14)20-11-27-21-2-3-22(29-31(20)21)30-12-16(25)9-19(30)17-8-15(24)10-28-23(17)32-13/h2-5,7-8,10-11,13,16,19H,6,9,12H2,1H3	DAALPXROAURTFB-UHFFFAOYSA-N	540288	(32R,34S,6R,E)-34,45-difluoro-6-methyl-5-oxa-2(3,6)-imidazo[1,2-b]pyridazina-1(2,4),4(3,2)-dipyridina-3(1,2)-pyrrolidinacycloheptaphane::US20260028352, Example I-40	High affinity nerve growth factor receptor	Homo sapiens		<3.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540288	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540288&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121447239	464925274							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238360	C[C@H]1Nc2ccc3ncc(n3n2)-c2cc(ccn2)N2CC[C@H](C2)Oc2ccc(F)cc21	InChI=1S/C23H21FN6O/c1-14-18-10-15(24)2-3-21(18)31-17-7-9-29(13-17)16-6-8-25-19(11-16)20-12-26-23-5-4-22(27-14)28-30(20)23/h2-6,8,10-12,14,17H,7,9,13H2,1H3,(H,27,28)	DOOASRFGZIHKNC-UHFFFAOYSA-N	540289	(33R,6R,E)-54-fluoro-6-methyl-4-oxa-7-aza-1(3,6)-imidazo[1,2-b]pyridazina-2(2,4)-pyridina-3(1,3)-pyrrolidina-5(1,2)-benzenacycloheptaphane::US20260028352, Example I-41	High affinity nerve growth factor receptor	Homo sapiens		<3.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540289	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540289&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121447297	464925275							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238361	C[C@H]1Nc2ccc3ncc(n3n2)-c2cc(ccn2)N2CC[C@@H](C2)Oc2ccc(F)cc21	InChI=1S/C23H21FN6O/c1-14-18-10-15(24)2-3-21(18)31-17-7-9-29(13-17)16-6-8-25-19(11-16)20-12-26-23-5-4-22(27-14)28-30(20)23/h2-6,8,10-12,14,17H,7,9,13H2,1H3,(H,27,28)	DOOASRFGZIHKNC-UHFFFAOYSA-N	540290	(33S,6R,E)-54-fluoro-6-methyl-4-oxa-7-aza-1(3,6)-imidazo[1,2-b]pyridazina-2(2,4)-pyridina-3(1,3)-pyrrolidina-5(1,2)-benzenacycloheptaphane::US20260028352, Example I-42	High affinity nerve growth factor receptor	Homo sapiens		<3.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540290	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540290&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121446966	464925276							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238362	C[C@H]1Nc2ccc3ncc(n3n2)-c2cc(ccn2)N2CCC[C@H](C2)Oc2ccc(F)cc21	InChI=1S/C24H23FN6O/c1-15-19-11-16(25)4-5-22(19)32-18-3-2-10-30(14-18)17-8-9-26-20(12-17)21-13-27-24-7-6-23(28-15)29-31(21)24/h4-9,11-13,15,18H,2-3,10,14H2,1H3,(H,28,29)	ZUACUTCXZIRTPG-UHFFFAOYSA-N	540291	(33R,6R,E)-54-fluoro-6-methyl-4-oxa-7-aza-1(3,6)-imidazo[1,2-b]pyridazina-2(2,4)-pyridina-3(1,3)-piperidina-5(1,2)-benzenacycloheptaphane::US20260028352, Example I-43	High affinity nerve growth factor receptor	Homo sapiens		<3.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540291	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540291&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121447438	464925277							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238363	C[C@H]1Nc2ccc3ncc(n3n2)-c2cc(ccn2)N2CCC[C@@H](C2)Oc2ccc(F)cc21	InChI=1S/C24H23FN6O/c1-15-19-11-16(25)4-5-22(19)32-18-3-2-10-30(14-18)17-8-9-26-20(12-17)21-13-27-24-7-6-23(28-15)29-31(21)24/h4-9,11-13,15,18H,2-3,10,14H2,1H3,(H,28,29)	ZUACUTCXZIRTPG-UHFFFAOYSA-N	540292	(33S,6R,E)-54-fluoro-6-methyl-4-oxa-7-aza-1(3,6)-imidazo[1,2-b]pyridazina-2(2,4)-pyridina-3(1,3)-piperidina-5(1,2)-benzenacycloheptaphane::US20260028352, Example I-44	High affinity nerve growth factor receptor	Homo sapiens		<3.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540292	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540292&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121447068	464925278							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238364	Fc1ccc2c(c1)[C@H]1CCCN1c1ccc3ncc(n3n1)-c1cc(ccn1)[C@H]1CCC[C@H]1O2	InChI=1S/C26H24FN5O/c27-17-6-7-24-19(14-17)21-4-2-12-31(21)26-9-8-25-29-15-22(32(25)30-26)20-13-16(10-11-28-20)18-3-1-5-23(18)33-24/h6-11,13-15,18,21,23H,1-5,12H2	SIEFKSAYOODFKQ-UHFFFAOYSA-N	540293	(8aR,11aR,16bR,E)-15-fluoro-8a,10,11,11a,16b,17,18,19-octahydro-9H-1,21-etheno-4,8-(metheno)benzo[b]cyclopenta[o]imidazo[1,5-h]pyrrolo[2,1-d][1]oxa[5,7,8,11]tetraazacyclohexadecine::US20260028352, Example I-45	High affinity nerve growth factor receptor	Homo sapiens		<3.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540293	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540293&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121447300	464925279							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238365	Fc1ccc2c(c1)[C@H]1CCCN1c1ccc3ncc(n3n1)-c1cc(ccn1)[C@@H]1CCC[C@H]1O2	InChI=1S/C26H24FN5O/c27-17-6-7-24-19(14-17)21-4-2-12-31(21)26-9-8-25-29-15-22(32(25)30-26)20-13-16(10-11-28-20)18-3-1-5-23(18)33-24/h6-11,13-15,18,21,23H,1-5,12H2	SIEFKSAYOODFKQ-UHFFFAOYSA-N	540294	(8aS,11aR,16bR,E)-15-fluoro-8a,10,11,11a,16b,17,18,19-octahydro-9H-1,21-etheno-4,8-(metheno)benzo[b]cyclopenta[o]imidazo[1,5-h]pyrrolo[2,1-d][1]oxa[5,7,8,11]tetraazacyclohexadecine::US20260028352, Example I-46	High affinity nerve growth factor receptor	Homo sapiens		<3.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540294	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540294&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121447071	464925280							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238366	Fc1ccc2c(c1)C1(CC1)Nc1ccc3ncc(n3n1)-c1cc(ccn1)CO2	InChI=1S/C21H16FN5O/c22-14-1-2-18-15(10-14)21(6-7-21)25-19-3-4-20-24-11-17(27(20)26-19)16-9-13(12-28-18)5-8-23-16/h1-5,8-11H,6-7,12H2,(H,25,26)	VDZVFKWNVUDGBV-UHFFFAOYSA-N	540295	(E)-4'-fluorospiro[cyclopropane-1,6'-4-oxa-7-aza-1(3,6)-imidazo[1,2-b]pyridazina-2(2,4)-pyridina-5(1,2)-benzenacycloheptaphane]::US20260028352, Example I-47	High affinity nerve growth factor receptor	Homo sapiens		<3.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540295	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540295&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121447309	464925281							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238367	CC1(C)Nc2ccc3ncc(n3n2)-c2cc(ccn2)COc2ccc(F)cc21	InChI=1S/C21H18FN5O/c1-21(2)15-10-14(22)3-4-18(15)28-12-13-7-8-23-16(9-13)17-11-24-20-6-5-19(25-21)26-27(17)20/h3-11H,12H2,1-2H3,(H,25,26)	QDCJOYWQNFJRGW-UHFFFAOYSA-N	540296	(E)-54-fluoro-6,6-dimethyl-4-oxa-7-aza-1(3,6)-imidazo[1,2-b]pyridazina-2(2,4)-pyridina-5(1,2)-benzenacycloheptaphane::US20260028352, Example I-48	High affinity nerve growth factor receptor	Homo sapiens		<3.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540296	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540296&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121447255	464925282							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238368	Fc1ccc2c(c1)[C@H]1C[C@H](F)CN1c1ccc3ncc(n3n1)-c1cc(ccn1)CO2	InChI=1S/C22H17F2N5O/c23-14-1-2-20-16(8-14)18-9-15(24)11-28(18)22-4-3-21-26-10-19(29(21)27-22)17-7-13(12-30-20)5-6-25-17/h1-8,10,15,18H,9,11-12H2	BINSPWKXEAOPRH-UHFFFAOYSA-N	540297	(14bR,E)-13-fluoro-14b,15,16,17-tetrahydro-9H-1,19-etheno-4,8-(metheno) benzo[b]imidazo[1,5-h]pyrrolo[2,1-d][1]oxa[5,7,8,11]tetraazacyclopentadecine::US20260028352, Example I-49	High affinity nerve growth factor receptor	Homo sapiens		<3.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540297	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540297&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121446968	464925283							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238369	Fc1ccc2c(c1)[C@H]1C[C@H](F)CN1c1ccc3ncc(n3n1)-c1cc(ccn1)CO2	InChI=1S/C22H17F2N5O/c23-14-1-2-20-16(8-14)18-9-15(24)11-28(18)22-4-3-21-26-10-19(29(21)27-22)17-7-13(12-30-20)5-6-25-17/h1-8,10,15,18H,9,11-12H2	BINSPWKXEAOPRH-UHFFFAOYSA-N	540298	(14bR,16S,E)-13,16-difluoro-14b,15,16,17-tetrahydro-9H-1,19-etheno-4,8-(metheno)benzo[b]imidazo[1,5-h]pyrrolo[2,1-d][1]oxa[5,7,8,11]tetraazacyclopentadecine::US20260028352, Example I-50	High affinity nerve growth factor receptor	Homo sapiens		<3.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540298	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540298&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121447312	464925284							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238370	Fc1cnc2c(c1)[C@H]1CCCN1c1ccc3ncc(n3n1)-c1cc(ccn1)CO2	InChI=1S/C21H17FN6O/c22-14-9-15-17-2-1-7-27(17)20-4-3-19-24-11-18(28(19)26-20)16-8-13(5-6-23-16)12-29-21(15)25-10-14/h3-6,8-11,17H,1-2,7,12H2	ONRFCQNOCUWSRL-UHFFFAOYSA-N	540299	(14bR,E)-13-fluoro-14b,15,16,17-tetrahydro-9H-1,19-etheno-4,8-(metheno) imidazo[1,5-h]pyrido[2,3-b]pyrrolo[2,1-d][1]oxa[5,7,8,11]tetraazacyclopentadecine::US20260028352, Example I-51	High affinity nerve growth factor receptor	Homo sapiens		<3.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540299	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540299&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121446971	464925285							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238371	Fc1cnc2c(c1)[C@H]1C[C@H](F)CN1c1ccc3ncc(n3n1)-c1cc(ncn1)CO2	InChI=1S/C20H15F2N7O/c21-11-3-14-16-4-12(22)8-28(16)19-2-1-18-23-7-17(29(18)27-19)15-5-13(25-10-26-15)9-30-20(14)24-6-11/h1-3,5-7,10,12,16H,4,8-9H2	ZMAVQOXFKKHZNV-UHFFFAOYSA-N	540300	(14bR,16S,E)-13,16-difluoro-14b,15,16,17-tetrahydro-9H-1,19-etheno-4,8-(metheno)imidazo[1,5-h]pyrido[2,3-b]pyrrolo[2,1-d][1]oxa[5,7,8,11]tetraazacyclopentadecine::US20260028352, Example I-52	High affinity nerve growth factor receptor	Homo sapiens		<3.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540300	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540300&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121447275	464925286							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238372	Fc1ccc2c(c1)[C@H]1CCCN1c1ccc3ncc(n3n1)-c1cc(ccn1)CCO2	InChI=1S/C23H20FN5O/c24-16-3-4-21-17(13-16)19-2-1-10-28(19)23-6-5-22-26-14-20(29(22)27-23)18-12-15(7-9-25-18)8-11-30-21/h3-7,9,12-14,19H,1-2,8,10-11H2	VIEWTTLKGSUVTD-UHFFFAOYSA-N	540301	(32R,E)-45-fluoro-5-oxa-2(3,6)-imidazo[1,2-b]pyridazina-1(2,4)-pyridina-3(1,2)-pyrrolidina-4(1,2)-benzenacycloheptaphane::US20260028352, Example I-53	High affinity nerve growth factor receptor	Homo sapiens		<3.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540301	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540301&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121446972	464925287							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238373	Fc1cnc2c(c1)[C@H]1C[C@H](F)CN1c1ccc3ncc(n3n1)-c1cc(ccn1)CCO2	InChI=1S/C22H18F2N6O/c23-14-8-16-18-9-15(24)12-29(18)21-2-1-20-26-11-19(30(20)28-21)17-7-13(3-5-25-17)4-6-31-22(16)27-10-14/h1-3,5,7-8,10-11,15,18H,4,6,9,12H2	MLQXYJATWUNBGZ-UHFFFAOYSA-N	540302	(32R,34S,E)-34,45-difluoro-5-oxa-2(3,6)-imidazo[1,2-b]pyridazina-1(2,4)-pyridina-3(1,2)-pyrrolidina-4(1,2)-benzenacycloheptaphane::US20260028352, Example I-54	High affinity nerve growth factor receptor	Homo sapiens		<3.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540302	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540302&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121447069	464925288							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238374	Fc1cnc2c(c1)[C@H]1CCCN1c1ccc3ncc(n3n1)-c1cc(ccn1)CCO2	InChI=1S/C22H19FN6O/c23-15-11-16-18-2-1-8-28(18)21-4-3-20-25-13-19(29(20)27-21)17-10-14(5-7-24-17)6-9-30-22(16)26-12-15/h3-5,7,10-13,18H,1-2,6,8-9H2	KQFMPZZXZZTNBZ-UHFFFAOYSA-N	540303	(32R,E)-45-fluoro-5-oxa-2(3,6)-imidazo[1,2-b]pyridazina-1(2,4),4(3,2)-dipyridina-3(1,2)-pyrrolidinacycloheptaphane::US20260028352, Example I-55	High affinity nerve growth factor receptor	Homo sapiens		<3.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540303	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540303&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121447441	464925289							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238375	Fc1ccc2c(c1)[C@H]1C[C@H](F)CN1c1ccc3ncc(n3n1)-c1cc(ccn1)CCO2	InChI=1S/C23H19F2N5O/c24-15-1-2-21-17(10-15)19-11-16(25)13-29(19)23-4-3-22-27-12-20(30(22)28-23)18-9-14(5-7-26-18)6-8-31-21/h1-5,7,9-10,12,16,19H,6,8,11,13H2	MAIDULXPIOZNTL-UHFFFAOYSA-N	540304	(32R,34S,E)-34,45-difluoro-5-oxa-2(3,6)-imidazo[1,2-b]pyridazina-1(2,4),4(3,2)-dipyridina-3(1,2)-pyrrolidinacycloheptaphane::US20260028352, Example I-56	High affinity nerve growth factor receptor	Homo sapiens		<3.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540304	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540304&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121446973	464925290							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238376	Fc1ccc2c(c1)[C@H]1CCCN1c1ccc3ncc(n3n1)-c1cc(ncn1)CO2	InChI=1S/C21H17FN6O/c22-13-3-4-19-15(8-13)17-2-1-7-27(17)21-6-5-20-23-10-18(28(20)26-21)16-9-14(11-29-19)24-12-25-16/h3-6,8-10,12,17H,1-2,7,11H2	OIYDYBOYIUGROP-UHFFFAOYSA-N	540305	(14bR,E)-13-fluoro-14b,15,16,17-tetrahydro-9H-1,19-etheno-4,8-(metheno) benzo[n]imidazo[5,1-h]pyrrolo[1,2-l][1]oxa[4,6,9,10,12]pentaazacyclopentadecine::US20260028352, Example I-57	High affinity nerve growth factor receptor	Homo sapiens		<3.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540305	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540305&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121447073	464925291							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238377	Fc1ccc2c(c1)[C@H]1C[C@H](F)CN1c1ccc3ncc(n3n1)-c1cc(ncn1)CO2	InChI=1S/C21H16F2N6O/c22-12-1-2-19-15(5-12)17-6-13(23)9-28(17)21-4-3-20-24-8-18(29(20)27-21)16-7-14(10-30-19)25-11-26-16/h1-5,7-8,11,13,17H,6,9-10H2	MZAYDDDYQCACRD-UHFFFAOYSA-N	540306	(14bR,16S,E)-13,16-difluoro-14b,15,16,17-tetrahydro-9H-1,19-etheno-4,8-(metheno)benzo[n]imidazo[5,1-h]pyrrolo[1,2-l][1]oxa[4,6,9,10,12]pentaazacyclopentadecine::US20260028352, Example I-58	High affinity nerve growth factor receptor	Homo sapiens		<3.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540306	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540306&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121447339	464925292							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238378	Fc1cnc2c(c1)[C@H]1CCCN1c1ccc3ncc(n3n1)-c1cc(ncn1)CO2	InChI=1S/C20H16FN7O/c21-12-6-14-16-2-1-5-27(16)19-4-3-18-22-9-17(28(18)26-19)15-7-13(24-11-25-15)10-29-20(14)23-8-12/h3-4,6-9,11,16H,1-2,5,10H2	PXUOTBWWSVWXDX-UHFFFAOYSA-N	540307	(14bR,E)-13-fluoro-14b,15,16,17-tetrahydro-9H-1,19-etheno-4,8-(metheno)imidazo[5,1-h]pyrido[3,2-n]pyrrolo[1,2-l][1]oxa[4,6,9,10,12]pentaazacyclopentadecine::US20260028352, Example I-59	High affinity nerve growth factor receptor	Homo sapiens		<3.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540307	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540307&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121447322	464925293							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238379	Fc1cnc2c(c1)[C@H]1C[C@H](F)CN1c1ccc3ncc(n3n1)-c1cc(ccn1)CO2	InChI=1S/C21H16F2N6O/c22-13-6-15-17-7-14(23)10-28(17)20-2-1-19-25-9-18(29(19)27-20)16-5-12(3-4-24-16)11-30-21(15)26-8-13/h1-6,8-9,14,17H,7,10-11H2	ZPJQJHCYCLMWCW-UHFFFAOYSA-N	540308	(14bR,16S,E)-13,16-difluoro-14b,15,16,17-tetrahydro-9H-1,19-etheno-4,8-(metheno)imidazo[5,1-h]pyrido[3,2-n]pyrrolo[1,2-l][1]oxa[4,6,9,10,12]pentaazacyclopentadecine::US20260028352, Example I-60	High affinity nerve growth factor receptor	Homo sapiens		<3.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540308	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540308&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121447075	464925294							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238380	Fc1ccc2c(c1)[C@H]1CCCN1c1ccc3ncc(n3n1)-c1nccc(n1)CO2	InChI=1S/C21H17FN6O/c22-13-3-4-18-15(10-13)16-2-1-9-27(16)20-6-5-19-24-11-17(28(19)26-20)21-23-8-7-14(25-21)12-29-18/h3-8,10-11,16H,1-2,9,12H2	FCEQQGRAAZAMDF-UHFFFAOYSA-N	540309	(14bR,E)-13-fluoro-14b,15,16,17-tetrahydro-9H-4,8-(azeno)-1,19-etheno benzo[b]imidazo[1,5-h]pyrrolo[2,1-d][1]oxa[5,7,8,11]tetraazacyclopentadecine::US20260028352, Example I-61	High affinity nerve growth factor receptor	Homo sapiens		<3.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540309	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540309&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121447318	464925295							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238381	Fc1cnc2c(c1)[C@H]1C[C@H](F)CN1c1ccc3ncc(n3n1)-c1cc(cnn1)CO2	InChI=1S/C20H15F2N7O/c21-12-4-14-16-5-13(22)9-28(16)19-2-1-18-23-8-17(29(18)27-19)15-3-11(6-25-26-15)10-30-20(14)24-7-12/h1-4,6-8,13,16H,5,9-10H2	ATYILKQOWBVURP-UHFFFAOYSA-N	540310	(14bR,16S,E)-13,16-difluoro-14b,15,16,17-tetrahydro-9H-4,8-(azeno)-1,19-ethenobenzo[b]imidazo[1,5-h]pyrrolo[2,1-d][1]oxa[5,7,8,11]tetraazacyclopentadecine::US20260028352, Example I-62	High affinity nerve growth factor receptor	Homo sapiens		<3.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540310	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540310&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121447343	464925296							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238382	Fc1cnc2c(c1)[C@H]1CCCN1c1ccc3ncc(n3n1)-c1nccc(n1)CO2	InChI=1S/C20H16FN7O/c21-12-8-14-15-2-1-7-27(15)18-4-3-17-23-10-16(28(17)26-18)19-22-6-5-13(25-19)11-29-20(14)24-9-12/h3-6,8-10,15H,1-2,7,11H2	UNUMGPSAYSQYBE-UHFFFAOYSA-N	540311	(14bR,E)-13-fluoro-14b,15,16,17-tetrahydro-9H-4,8-(azeno)-1,19-etheno imidazo[1,5-h]pyrido[2,3-b]pyrrolo[2,1-d][1]oxa[5,7,8,11]tetraazacyclopentadecine::US20260028352, Example I-63	High affinity nerve growth factor receptor	Homo sapiens		<3.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540311	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540311&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121447205	464925297							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238383	Fc1cnc2c(c1)[C@H]1C[C@H](F)CN1c1ccc3ncc(n3n1)-c1nccc(n1)CO2	InChI=1S/C20H15F2N7O/c21-11-5-14-15-6-12(22)9-28(15)18-2-1-17-24-8-16(29(17)27-18)19-23-4-3-13(26-19)10-30-20(14)25-7-11/h1-5,7-8,12,15H,6,9-10H2	LJYVKGCQLRGKIB-UHFFFAOYSA-N	540312	(14bR,16S,E)-13,16-difluoro-14b,15,16,17-tetrahydro-9H-4,8-(azeno)-1,19-ethenoimidazo[1,5-h]pyrido[2,3-b]pyrrolo[2,1-d][1]oxa[5,7,8,11]tetraazacyclopentadecine::US20260028352, Example I-64	High affinity nerve growth factor receptor	Homo sapiens		<3.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540312	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540312&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121446969	464925298							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238384	Fc1ccc2c(c1)[C@H]1CCCN1c1ccc3ncc(n3n1)-c1cc(cnn1)CO2	InChI=1S/C21H17FN6O/c22-14-3-4-19-15(9-14)17-2-1-7-27(17)21-6-5-20-23-11-18(28(20)26-21)16-8-13(12-29-19)10-24-25-16/h3-6,8-11,17H,1-2,7,12H2	CQNYEEZABCEQOT-UHFFFAOYSA-N	540313	(14bR,E)-13-fluoro-14b,15,16,17-tetrahydro-9H-1,19-etheno-4,8-(metheno) benzo[n]imidazo[5,1-h]pyrrolo[1,2-l][1]oxa[5,6,9,10,12]pentaazacyclopentadecine::US20260028352, Example I-65	High affinity nerve growth factor receptor	Homo sapiens		<3.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540313	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540313&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121446974	464925299							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238385	Fc1ccc2c(c1)[C@H]1C[C@H](F)CN1c1ccc3ncc(n3n1)-c1nccc(n1)CO2	InChI=1S/C21H16F2N6O/c22-12-1-2-18-15(7-12)16-8-13(23)10-28(16)20-4-3-19-25-9-17(29(19)27-20)21-24-6-5-14(26-21)11-30-18/h1-7,9,13,16H,8,10-11H2	DFIOTNNBLLFSRF-UHFFFAOYSA-N	540314	(14bR,16S,E)-13,16-difluoro-14b,15,16,17-tetrahydro-9H-1,19-etheno-4,8-(metheno)benzo[n]imidazo[5,1-h]pyrrolo[1,2-l][1]oxa[5,6,9,10,12]pentaazacyclopentadecine::US20260028352, Example I-66	High affinity nerve growth factor receptor	Homo sapiens		<3.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540314	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540314&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121447077	464925300							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238386	Fc1cnc2c(c1)[C@H]1CCCN1c1ccc3ncc(n3n1)-c1cc(cnn1)CO2	InChI=1S/C20H16FN7O/c21-13-7-14-16-2-1-5-27(16)19-4-3-18-22-10-17(28(18)26-19)15-6-12(8-24-25-15)11-29-20(14)23-9-13/h3-4,6-10,16H,1-2,5,11H2	WWKFZRNWDBCJCY-UHFFFAOYSA-N	540315	(14bR,E)-13-fluoro-14b,15,16,17-tetrahydro-9H-1,19-etheno-4,8-(metheno) imidazo[5,1-h]pyrido[3,2-n]pyrrolo[1,2-l][1]oxa[5,6,9,10,12]pentaazacyclopentadecine::US20260028352, Example I-67	High affinity nerve growth factor receptor	Homo sapiens		<3.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540315	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540315&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121446975	464925301							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238387	Fc1ccc2c(c1)[C@H]1C[C@H](F)CN1c1ccc3ncc(n3n1)-c1cc(cnn1)CO2	InChI=1S/C21H16F2N6O/c22-13-1-2-19-15(6-13)17-7-14(23)10-28(17)21-4-3-20-24-9-18(29(20)27-21)16-5-12(11-30-19)8-25-26-16/h1-6,8-9,14,17H,7,10-11H2	LEDGGLVDWQTARF-UHFFFAOYSA-N	540316	(14bR,16S,E)-13,16-difluoro-14b,15,16,17-tetrahydro-9H-1,19-etheno-4,8-(metheno)imidazo[5,1-h]pyrido[3,2-n]pyrrolo[1,2-l][1]oxa[5,6,9,10,12]pentaazacyclopentadecine::US20260028352, Example I-68	High affinity nerve growth factor receptor	Homo sapiens		<3.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540316	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540316&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121447445	464925302							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238388	Fc1ccc2c(c1)[C@H]1CCCN1c1ccc3ncc(n3n1)-c1cc(ncn1)CO2	InChI=1S/C21H17FN6O/c22-13-3-4-19-15(8-13)17-2-1-7-27(17)21-6-5-20-23-10-18(28(20)26-21)16-9-14(11-29-19)24-12-25-16/h3-6,8-10,12,17H,1-2,7,11H2	OIYDYBOYIUGROP-UHFFFAOYSA-N	540317	(32R,E)-45-fluoro-5-oxa-2(3,6)-imidazo[1,2-b]pyridazina-1(4,6)-pyrimidina-3(1,2)-pyrrolidina-4(1,2)-benzenacycloheptaphane::US20260028352, Example I-69	High affinity nerve growth factor receptor	Homo sapiens		<3.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540317	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540317&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121447085	464925303							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238389	Fc1ccc2c(c1)[C@H]1C[C@H](F)CN1c1ccc3ncc(n3n1)-c1cc(ncn1)CCO2	InChI=1S/C22H18F2N6O/c23-13-1-2-20-16(7-13)18-8-14(24)11-29(18)22-4-3-21-25-10-19(30(21)28-22)17-9-15(5-6-31-20)26-12-27-17/h1-4,7,9-10,12,14,18H,5-6,8,11H2	WHLUHJOHEFPOHI-UHFFFAOYSA-N	540318	(32R,34S,E)-34,45-difluoro-5-oxa-2(3,6)-imidazo[1,2-b]pyridazina-1(4,6)-pyrimidina-3(1,2)-pyrrolidina-4(1,2)-benzenacycloheptaphane::US20260028352, Example I-70	High affinity nerve growth factor receptor	Homo sapiens		<3.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540318	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540318&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121446976	464925304							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238390	Fc1cnc2c(c1)[C@H]1CCCN1c1ccc3ncc(n3n1)-c1cc(ncn1)CCO2	InChI=1S/C21H18FN7O/c22-13-8-15-17-2-1-6-28(17)20-4-3-19-23-11-18(29(19)27-20)16-9-14(25-12-26-16)5-7-30-21(15)24-10-13/h3-4,8-12,17H,1-2,5-7H2	WLZWOPAABXIFFV-UHFFFAOYSA-N	540319	(32R,E)-45-fluoro-5-oxa-2(3,6)-imidazo[1,2-b]pyridazina-1(4,6)-pyrimidina-4(3,2)-pyridina-3(1,2)-pyrrolidinacycloheptaphane::US20260028352, Example I-71	High affinity nerve growth factor receptor	Homo sapiens		<3.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540319	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540319&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121447098	464925305							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238391	Fc1cnc2c(c1)[C@H]1C[C@H](F)CN1c1ccc3ncc(n3n1)-c1cc(ncn1)CCO2	InChI=1S/C21H17F2N7O/c22-12-5-15-17-6-13(23)10-29(17)20-2-1-19-24-9-18(30(19)28-20)16-7-14(26-11-27-16)3-4-31-21(15)25-8-12/h1-2,5,7-9,11,13,17H,3-4,6,10H2	CUULFGGGQZBVCS-UHFFFAOYSA-N	540320	(32R,34S,E)-34,45-difluoro-5-oxa-2(3,6)-imidazo[1,2-b]pyridazina-1(4,6)-pyrimidina-4(3,2)-pyridina-3(1,2)-pyrrolidinacycloheptaphane::US20260028352, Example I-72	High affinity nerve growth factor receptor	Homo sapiens		<3.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540320	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540320&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121447332	464925306							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238392	C[C@H]1Nc2ccc3ncc(n3n2)-c2cc(ncn2)CCOc2ncc(F)cc21	InChI=1S/C19H16FN7O/c1-11-14-6-12(20)8-22-19(14)28-5-4-13-7-15(24-10-23-13)16-9-21-18-3-2-17(25-11)26-27(16)18/h2-3,6-11H,4-5H2,1H3,(H,25,26)	FBPVDMBEPUUANT-UHFFFAOYSA-N	540321	(4R,E)-5'-fluoro-4-methyl-6-oxa-3-aza-2(3,6)-imidazo[1,2-b]pyridazina-1(4,6)-pyrimidina-5(3,2)-pyridinacyclooctaphane::US20260028352, Example I-73	High affinity nerve growth factor receptor	Homo sapiens		<3.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540321	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540321&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121447335	464925307							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238393	C[C@H]1Nc2ccc3ncc(n3n2)-c2cc(ncn2)CCOc2ccc(F)cc21	InChI=1S/C20H17FN6O/c1-12-15-8-13(21)2-3-18(15)28-7-6-14-9-16(24-11-23-14)17-10-22-20-5-4-19(25-12)26-27(17)20/h2-5,8-12H,6-7H2,1H3,(H,25,26)	WHBFUIBQLJAOBJ-UHFFFAOYSA-N	540322	(4R,E)-5'-fluoro-4-methyl-6-oxa-3-aza-2(3,6)-imidazo[1,2-b]pyridazina-1(4,6)-pyrimidina-5(1,2)-benzenacyclooctaphane::US20260028352, Example I-74	High affinity nerve growth factor receptor	Homo sapiens		<3.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540322	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540322&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121446977	464925308							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238394	C[C@H]1Nc2ccc3ncc(n3n2)-c2cc(ccn2)CCOc2ncc(F)cc21	InChI=1S/C20H17FN6O/c1-12-15-9-14(21)10-24-20(15)28-7-5-13-4-6-22-16(8-13)17-11-23-19-3-2-18(25-12)26-27(17)19/h2-4,6,8-12H,5,7H2,1H3,(H,25,26)	AGLVDSNFFPPJKF-UHFFFAOYSA-N	540323	(4R,E)-55-fluoro-4-methyl-6-oxa-3-aza-2(3,6)-imidazo[1,2-b]pyridazina-1(2,4), 5(3,2)-dipyridinacyclooctaphane::US20260028352, Example I-75	High affinity nerve growth factor receptor	Homo sapiens		<3.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540323	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540323&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121447342	464925309							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238395	C[C@H]1Nc2ccc3ncc(n3n2)-c2cc(ccn2)CCOc2ccc(F)cc21	InChI=1S/C21H18FN5O/c1-13-16-11-15(22)2-3-19(16)28-9-7-14-6-8-23-17(10-14)18-12-24-21-5-4-20(25-13)26-27(18)21/h2-6,8,10-13H,7,9H2,1H3,(H,25,26)	XZENVYVAUNFWEK-UHFFFAOYSA-N	540324	(4R,E)-5'-fluoro-4-methyl-6-oxa-3-aza-2(3,6)-imidazo[1,2-b]pyridazina-1(2,4)-pyridina-5(1,2)-benzenacyclooctaphane::US20260028352, Example I-76	High affinity nerve growth factor receptor	Homo sapiens		<3.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540324	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540324&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121447388	464925310							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238396	C[C@H]1Nc2ccc3ncc(n3n2)-c2cc(ncn2)COc2ncc(F)cc21	InChI=1S/C18H14FN7O/c1-10-13-4-11(19)6-21-18(13)27-8-12-5-14(23-9-22-12)15-7-20-17-3-2-16(24-10)25-26(15)17/h2-7,9-10H,8H2,1H3,(H,24,25)	UCZSCXRKHPPSHQ-UHFFFAOYSA-N	540325	(6R,E)-55-fluoro-6-methyl-4-oxa-7-aza-1(3,6)-imidazo[1,2-b]pyridazina-2(4,6)-pyrimidina-5(2,3)-pyridinacycloheptaphane::US20260028352, Example I-77	High affinity nerve growth factor receptor	Homo sapiens		<3.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540325	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540325&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121447449	464925311							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238397	C[C@H]1Nc2ccc3ncc(n3n2)-c2cc(ncn2)COc2ccc(F)cc21	InChI=1S/C19H15FN6O/c1-11-14-6-12(20)2-3-17(14)27-9-13-7-15(23-10-22-13)16-8-21-19-5-4-18(24-11)25-26(16)19/h2-8,10-11H,9H2,1H3,(H,24,25)	AGEWFHRKAPCCTC-UHFFFAOYSA-N	540326	(6R,E)-54-fluoro-6-methyl-4-oxa-7-aza-1(3,6)-imidazo[1,2-b]pyridazina-2(4,6)-pyrimidina-5(1,2)-benzenacycloheptaphane::US20260028352, Example I-78	High affinity nerve growth factor receptor	Homo sapiens		<3.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540326	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540326&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121446979	464925312							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238398	C[C@H]1Nc2ccc3ncc(n3n2)-c2cc(cnn2)COc2ncc(F)cc21	InChI=1S/C18H14FN7O/c1-10-13-5-12(19)7-21-18(13)27-9-11-4-14(24-22-6-11)15-8-20-17-3-2-16(23-10)25-26(15)17/h2-8,10H,9H2,1H3,(H,23,25)	ZLLHYJSRMXVLPA-UHFFFAOYSA-N	540327	(6R,E)-55-fluoro-6-methyl-4-oxa-7-aza-1(3,6)-imidazo[1,2-b]pyridazina-2(2,4)-pyrimidina-5(2,3)-pyridinacycloheptaphane::US20260028352, Example I-79	High affinity nerve growth factor receptor	Homo sapiens		<3.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540327	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540327&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121446978	464925313							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238399	C[C@H]1Nc2ccc3ncc(n3n2)-c2nccc(n2)COc2ccc(F)cc21	InChI=1S/C19H15FN6O/c1-11-14-8-12(20)2-3-16(14)27-10-13-6-7-21-19(24-13)15-9-22-18-5-4-17(23-11)25-26(15)18/h2-9,11H,10H2,1H3,(H,23,25)	BYGBVECBYAMPII-UHFFFAOYSA-N	540328	(6R,E)-54-fluoro-6-methyl-4-oxa-7-aza-1(3,6)-imidazo[1,2-b]pyridazina-2(2,4)-pyrimidina-5(1,2)-benzenacycloheptaphane::US20260028352, Example I-80	High affinity nerve growth factor receptor	Homo sapiens		<3.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540328	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540328&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121447355	464925314							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238400	C[C@H]1Nc2ccc3ncc(n3n2)-c2nccc(n2)COc2ncc(F)cc21	InChI=1S/C18H14FN7O/c1-10-13-6-11(19)7-22-18(13)27-9-12-4-5-20-17(24-12)14-8-21-16-3-2-15(23-10)25-26(14)16/h2-8,10H,9H2,1H3,(H,23,25)	OQQZEJIPQHVGQX-UHFFFAOYSA-N	540329	(6R,E)-55-fluoro-6-methyl-4-oxa-7-aza-1(3,6)-imidazo[1,2-b]pyridazina-2(3,5)-pyridazina-5(2,3)-pyridinacycloheptaphane::US20260028352, Example I-81	High affinity nerve growth factor receptor	Homo sapiens		<3.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540329	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540329&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121447461	464925315							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238401	C[C@H]1Nc2ccc3ncc(n3n2)-c2cc(cnn2)COc2ccc(F)cc21	InChI=1S/C19H15FN6O/c1-11-14-7-13(20)2-3-17(14)27-10-12-6-15(24-22-8-12)16-9-21-19-5-4-18(23-11)25-26(16)19/h2-9,11H,10H2,1H3,(H,23,25)	IJVJPIMDCODZAB-UHFFFAOYSA-N	540330	(6R,E)-54-fluoro-6-methyl-4-oxa-7-aza-1(3,6)-imidazo[1,2-b]pyridazina-2(3,5)-pyridazina-5(1,2)-benzenacycloheptaphane::US20260028352, Example I-82	High affinity nerve growth factor receptor	Homo sapiens		<3.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540330	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540330&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121447458	464925316							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238402	C[C@H]1Nc2ccc3ncc(n3n2)-c2nccc(n2)CCOc2ncc(F)cc21	InChI=1S/C19H16FN7O/c1-11-14-8-12(20)9-23-19(14)28-7-5-13-4-6-21-18(25-13)15-10-22-17-3-2-16(24-11)26-27(15)17/h2-4,6,8-11H,5,7H2,1H3,(H,24,26)	MNVXNXSGPBOSBR-UHFFFAOYSA-N	540331	(4R,E)-5'-fluoro-4-methyl-6-oxa-3-aza-2(3,6)-imidazo[1,2-b]pyridazina-1(2,4)-pyrimidina-5(3,2)-pyridinacyclooctaphane::US20260028352, Example I-83	High affinity nerve growth factor receptor	Homo sapiens		<3.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540331	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540331&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121447460	464925317							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238403	C[C@H]1Nc2ccc3ncc(n3n2)-c2nccc(n2)CCOc2ccc(F)cc21	InChI=1S/C20H17FN6O/c1-12-15-10-13(21)2-3-17(15)28-9-7-14-6-8-22-20(25-14)16-11-23-19-5-4-18(24-12)26-27(16)19/h2-6,8,10-12H,7,9H2,1H3,(H,24,26)	PNDCHWPHEFOMOG-UHFFFAOYSA-N	540332	(4R,E)-55-fluoro-4-methyl-6-oxa-3-aza-2(3,6)-imidazo[1,2-b]pyridazina-1(2,4)-pyrimidina-5(1,2)-benzenacyclooctaphane::US20260028352, Example I-84	High affinity nerve growth factor receptor	Homo sapiens		<3.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540332	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540332&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121447208	464925318							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238404	Fc1ccc2c(c1)[C@H]1CCCN1c1ccc3ncc(n3n1)-c1cc(cnn1)CCO2	InChI=1S/C22H19FN6O/c23-15-3-4-20-16(11-15)18-2-1-8-28(18)22-6-5-21-24-13-19(29(21)27-22)17-10-14(7-9-30-20)12-25-26-17/h3-6,10-13,18H,1-2,7-9H2	VIFOCYIRFRXQGF-UHFFFAOYSA-N	540333	(32R,E)-45-fluoro-5-oxa-2(3,6)-imidazo[1,2-b]pyridazina-1(2,4)-pyrimidina-3(1,2)-pyrrolidina-4(1,2)-benzenacycloheptaphane::US20260028352, Example I-85	High affinity nerve growth factor receptor	Homo sapiens		<3.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540333	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540333&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121446993	464925319							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238405	Fc1ccc2c(c1)[C@H]1C[C@H](F)CN1c1ccc3ncc(n3n1)-c1cc(cnn1)CCO2	InChI=1S/C22H18F2N6O/c23-14-1-2-20-16(8-14)18-9-15(24)12-29(18)22-4-3-21-25-11-19(30(21)28-22)17-7-13(5-6-31-20)10-26-27-17/h1-4,7-8,10-11,15,18H,5-6,9,12H2	ZEZNDHCNBDOTRM-UHFFFAOYSA-N	540334	(32R,34S,E)-34,45-difluoro-5-oxa-2(3,6)-imidazo[1,2-b]pyridazina-1(2,4)-pyrimidina-3(1,2)-pyrrolidina-4(1,2)-benzenacycloheptaphane::US20260028352, Example I-86	High affinity nerve growth factor receptor	Homo sapiens		<3.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540334	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540334&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121447096	464925320							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238406	Fc1cnc2c(c1)[C@H]1CCCN1c1ccc3ncc(n3n1)-c1cc(cnn1)CCO2	InChI=1S/C21H18FN7O/c22-14-9-15-17-2-1-6-28(17)20-4-3-19-23-12-18(29(19)27-20)16-8-13(10-25-26-16)5-7-30-21(15)24-11-14/h3-4,8-12,17H,1-2,5-7H2	QOLNLLQKCFGNAI-UHFFFAOYSA-N	540335	(32R,E)-45-fluoro-5-oxa-2(3,6)-imidazo[1,2-b]pyridazina-1(2,4)-pyrimidina-4(3,2)-pyridina-3(1,2)-pyrrolidinacycloheptaphane::US20260028352, Example I-87	High affinity nerve growth factor receptor	Homo sapiens		<3.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540335	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540335&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121447459	464925321							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238407	Fc1cnc2c(c1)[C@H]1C[C@H](F)CN1c1ccc3ncc(n3n1)-c1cc(cnn1)CCO2	InChI=1S/C21H17F2N7O/c22-13-6-15-17-7-14(23)11-29(17)20-2-1-19-24-10-18(30(19)28-20)16-5-12(8-26-27-16)3-4-31-21(15)25-9-13/h1-2,5-6,8-10,14,17H,3-4,7,11H2	KRDMHZJTFZABTE-UHFFFAOYSA-N	540336	(32R,34S,E)-34,45-difluoro-5-oxa-2(3,6)-imidazo[1,2-b]pyridazina-1(2,4)-pyrimidina-4(3,2)-pyridina-3(1,2)-pyrrolidinacycloheptaphane::US20260028352, Example I-88	High affinity nerve growth factor receptor	Homo sapiens		<3.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540336	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540336&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121447362	464925322							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238408	C[C@H]1Nc2ccc3ncc(n3n2)-c2cc(cnn2)CCOc2ncc(F)cc21	InChI=1S/C19H16FN7O/c1-11-14-7-13(20)9-22-19(14)28-5-4-12-6-15(25-23-8-12)16-10-21-18-3-2-17(24-11)26-27(16)18/h2-3,6-11H,4-5H2,1H3,(H,24,26)	URFRZVBRUIDOFM-UHFFFAOYSA-N	540337	(4R,E)-5-fluoro-4-methyl-6-oxa-3-aza-2(3,6)-imidazo[1,2-b]pyridazina-1(3,5)-pyridazina-5(3,2)-pyridinacyclooctaphane::US20260028352, Example I-89	High affinity nerve growth factor receptor	Homo sapiens		<3.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540337	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540337&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121447361	464925323							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238409	Cc1ccc2c(c1)[C@H]1C[C@H](F)CN1c1ccc3ncc(n3n1)-c1cc(ncn1)C[C@@H](C)O2	InChI=1S/C24H23FN6O/c1-14-3-4-22-18(7-14)20-9-16(25)12-30(20)24-6-5-23-26-11-21(31(23)29-24)19-10-17(27-13-28-19)8-15(2)32-22/h3-7,10-11,13,15-16,20H,8-9,12H2,1-2H3	STKXNCGIJKZKPO-UHFFFAOYSA-N	540338	(32R,E)-45-fluoro-5-oxa-2(3,6)-imidazo[1,2-b]pyridazina-1(3,5)-pyridazina-3(1,2)-pyrrolidina-4(1,2)-benzenacycloheptaphane::US20260028352, Example I-91	High affinity nerve growth factor receptor	Homo sapiens		<3.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540338	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540338&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121447240	464925324							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238410	Fc1ccc2c(c1)[C@H]1CCCN1c1ccc3ncc(n3n1)-c1nccc(n1)CCO2	InChI=1S/C22H19FN6O/c23-14-3-4-19-16(12-14)17-2-1-10-28(17)21-6-5-20-25-13-18(29(20)27-21)22-24-9-7-15(26-22)8-11-30-19/h3-7,9,12-13,17H,1-2,8,10-11H2	AJOLLQOIWWMNAL-UHFFFAOYSA-N	540339	(32R,34S,E)-34,45-difluoro-5-oxa-2(3,6)-imidazo[1,2-b]pyridazina-1(3,5)-pyridazina-3(1,2)-pyrrolidina-4(1,2)-benzenacycloheptaphane::US20260028352, Example I-92	High affinity nerve growth factor receptor	Homo sapiens		<3.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540339	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540339&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121447469	464925325							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238411	Fc1ccc2c(c1)[C@H]1C[C@H](F)CN1c1ccc3ncc(n3n1)-c1nccc(n1)CCO2	InChI=1S/C22H18F2N6O/c23-13-1-2-19-16(9-13)17-10-14(24)12-29(17)21-4-3-20-26-11-18(30(20)28-21)22-25-7-5-15(27-22)6-8-31-19/h1-5,7,9,11,14,17H,6,8,10,12H2	WXTNRBNDUNEAMP-UHFFFAOYSA-N	540340	(32R,E)-45-fluoro-5-oxa-2(3,6)-imidazo[1,2-b]pyridazina-1(3,5)-pyridazina-4(3,2)-pyridina-3(1,2)-pyrrolidinacycloheptaphane::US20260028352, Example I-93	High affinity nerve growth factor receptor	Homo sapiens		<3.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540340	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540340&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121447097	464925326							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238412	Fc1cnc2c(c1)[C@H]1CCCN1c1ccc3ncc(n3n1)-c1nccc(n1)CCO2	InChI=1S/C21H18FN7O/c22-13-10-15-16-2-1-8-28(16)19-4-3-18-24-12-17(29(18)27-19)20-23-7-5-14(26-20)6-9-30-21(15)25-11-13/h3-5,7,10-12,16H,1-2,6,8-9H2	OXNMAOWCSBZHCX-UHFFFAOYSA-N	540341	(32R,34S,E)-34,4-difluoro-5-oxa-2(3,6)-imidazo[1,2-b]pyridazina-1(3,5)-pyridazina-4(3,2)-pyridina-3(1,2)-pyrrolidinacycloheptaphane::US20260028352, Example I-94	High affinity nerve growth factor receptor	Homo sapiens		<3.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540341	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540341&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121447369	464925327							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238413	C[C@H]1Cc2ccnc(n2)-c2cnc3ccc(nn23)N2CCC[C@@H]2c2cc(F)cnc2O1	InChI=1S/C22H20FN7O/c1-13-9-15-6-7-24-21(27-15)18-12-25-19-4-5-20(28-30(18)19)29-8-2-3-17(29)16-10-14(23)11-26-22(16)31-13/h4-7,10-13,17H,2-3,8-9H2,1H3	HISWMXAMZABLCC-UHFFFAOYSA-N	540342	(32R,6S,E)-4-fluoro-6-methyl-5-oxa-2(3,6)-imidazo[1,2-b]pyridazina-1(2,4)-pyrimidina-4(3,2)-pyridina-3(1,2)-pyrrolidinacycloheptaphane::US20260028352, Example I-95	High affinity nerve growth factor receptor	Homo sapiens		<3.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540342	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540342&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121447101	464925328							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238414	C[C@H]1Cc2ccnc(n2)-c2cnc3ccc(nn23)N2C[C@@H](F)C[C@@H]2c2cc(F)cnc2O1	InChI=1S/C22H19F2N7O/c1-12-6-15-4-5-25-21(28-15)18-10-26-19-2-3-20(29-31(18)19)30-11-14(24)8-17(30)16-7-13(23)9-27-22(16)32-12/h2-5,7,9-10,12,14,17H,6,8,11H2,1H3	OZEFUYILFLZQOJ-UHFFFAOYSA-N	540343	(32R,34S,6S,E)-34,45-difluoro-6-methyl-5-oxa-2(3,6)-imidazo[1,2-b]pyridazina-1(2,4)-pyrimidina-4(3,2)-pyridina-3(1,2)-pyrrolidinacycloheptaphane::US20260028352, Example I-96	High affinity nerve growth factor receptor	Homo sapiens		<3.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540343	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540343&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121447244	464925329							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238415	C[C@@H]1Cc2cc(ncn2)-c2cnc3ccc(nn23)N2CCC[C@@H]2c2cc(F)ccc2O1	InChI=1S/C23H21FN6O/c1-14-9-16-11-18(27-13-26-16)20-12-25-22-6-7-23(28-30(20)22)29-8-2-3-19(29)17-10-15(24)4-5-21(17)31-14/h4-7,10-14,19H,2-3,8-9H2,1H3	KJONIUKEHHAWPC-UHFFFAOYSA-N	540344	(32R,6R,E)-45-fluoro-6-methyl-5-oxa-2(3,6)-imidazo[1,2-b]pyridazina-1(4,6)-pyrimidina-3(1,2)-pyrrolidina-4(1,2)-benzenacycloheptaphane::US20260028352, Example I-97	High affinity nerve growth factor receptor	Homo sapiens		<3.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540344	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540344&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121447474	464925330							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238416	Fc1cnc2c(c1)[C@H]1C[C@H](F)CN1c1ccc3ncc(n3n1)-c1nccc(n1)CCO2	InChI=1S/C21H17F2N7O/c22-12-7-15-16-8-13(23)11-29(16)19-2-1-18-25-10-17(30(18)28-19)20-24-5-3-14(27-20)4-6-31-21(15)26-9-12/h1-3,5,7,9-10,13,16H,4,6,8,11H2	WLVFPGQPYJJSMY-UHFFFAOYSA-N	540345	(32R,34S,6R,E)-34,45-difluoro-6-methyl-5-oxa-2(3,6)-imidazo[1,2-b]pyridazina-1(4,6)-pyrimidina-3(1,2)-pyrrolidina-4(1,2)-benzenacycloheptaphane::US20260028352, Example I-98	High affinity nerve growth factor receptor	Homo sapiens		<3.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540345	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540345&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			121447107	464925331							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238417	C[C@@H]1CCc2ncc(F)cc2[C@H]2CCCN2c2ccn3ncc(C(=O)N1)c3n2	InChI=1S/C20H21FN6O/c1-12-4-5-16-14(9-13(21)10-22-16)17-3-2-7-26(17)18-6-8-27-19(25-18)15(11-23-27)20(28)24-12/h6,8-12,17H,2-5,7H2,1H3,(H,24,28)	OEBIHOVSAMBXIB-UHFFFAOYSA-N	50507492	Loxo-195::Selitrectinib::US10966985, Compound 33-B::US12428433, Example LOXO-195::US20260028352, Example LOXO-195	High affinity nerve growth factor receptor	Homo sapiens		 3.50							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50507492	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50507492&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search			129103609	440716077							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238418	CC1Nc2ccc3ncc(n3n2)-c2cc(ccn2)COc2ccc(F)cc21	InChI=1S/C20H16FN5O/c1-12-15-9-14(21)2-3-18(15)27-11-13-6-7-22-16(8-13)17-10-23-20-5-4-19(24-12)25-26(17)20/h2-10,12H,11H2,1H3,(H,24,25)	ORCBEAXRXVSMKD-UHFFFAOYSA-N	540249	(E)-5-fluoro-6-methyl-4-oxa-7-aza-1-imidazo[1,2-b]pyridazine-2-pyridine-5-benzenacycloheptaphane::US20260028352, Example I-1	High affinity nerve growth factor receptor NTRK1 [F589L]			 5.40							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540249	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2119&target=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540249&enzyme=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search			121447050	464925235							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVLEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,8J5W,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238419	CC1Nc2ccc3ncc(n3n2)-c2cc(ccn2)COc2c(F)cc(F)cc21	InChI=1S/C20H15F2N5O/c1-11-14-7-13(21)8-15(22)20(14)28-10-12-4-5-23-16(6-12)17-9-24-19-3-2-18(25-11)26-27(17)19/h2-9,11H,10H2,1H3,(H,25,26)	GVUUYSHGOSPJRA-UHFFFAOYSA-N	540250	(E)-5,5'-difluoro-6-methyl-4-oxa-7-aza-1(3,6)-imidazo[1,2-b]pyridazine-2(2,4)-pyridina-5(1,2)-benzenacycloheptaphane::US20260028352, Example I-2	High affinity nerve growth factor receptor NTRK1 [F589L]			 6.20							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540250	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2119&target=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540250&enzyme=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search			121447054	464925236							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVLEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,8J5W,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238420	CC1Nc2ccc3ncc(n3n2)-c2cc(ccn2)COc2ccccc21	InChI=1S/C20H17N5O/c1-13-15-4-2-3-5-18(15)26-12-14-8-9-21-16(10-14)17-11-22-20-7-6-19(23-13)24-25(17)20/h2-11,13H,12H2,1H3,(H,23,24)	AAGFEFPZUYTMTD-UHFFFAOYSA-N	540251	(E)-6-methyl-4-oxa-7-aza-1(3,6)-imidazo[1,2-b]pyridazine-2(2,4)-pyridine-5(1,2)-benzenacycloheptaphane::US20260028352, Example I-3	High affinity nerve growth factor receptor NTRK1 [F589L]			 7.10							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540251	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2119&target=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540251&enzyme=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search			121447053	464925237							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVLEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,8J5W,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238421	CC1Nc2ccc3ncc(n3n2)-c2cc(ccn2)COc2ccc(F)cc21	InChI=1S/C20H16FN5O/c1-12-15-9-14(21)2-3-18(15)27-11-13-6-7-22-16(8-13)17-10-23-20-5-4-19(24-12)25-26(17)20/h2-10,12H,11H2,1H3,(H,24,25)	ORCBEAXRXVSMKD-UHFFFAOYSA-N	540252	(E)-6-methyl-4-oxa-7-aza-1(3,6)-imidazo[1,2-b]pyridazina-2(2,4), 5(2,3)-dipyridinacycloheptaphane::US20260028352, Example I-4	High affinity nerve growth factor receptor NTRK1 [F589L]			 5.80							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540252	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2119&target=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540252&enzyme=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search			121446958	464925238							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVLEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,8J5W,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238422	CC1Nc2ccc3ncc(n3n2)-c2cc(ccn2)COc2ncc(F)cc21	InChI=1S/C19H15FN6O/c1-11-14-7-13(20)8-23-19(14)27-10-12-4-5-21-15(6-12)16-9-22-18-3-2-17(24-11)25-26(16)18/h2-9,11H,10H2,1H3,(H,24,25)	ASCFZLSPYXOWEP-UHFFFAOYSA-N	540253	(E)-54-fluoro-4-oxa-7-aza-1(3,6)-imidazo[1,2-b]pyridazina-2(2,4)-pyridina-5(1,2)-benzenacycloheptaphane::US20260028352, Example I-5	High affinity nerve growth factor receptor NTRK1 [F589L]			<5.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540253	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2119&target=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540253&enzyme=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search			121447304	464925239							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVLEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,8J5W,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238423	c1ccc2c(c1)CNc1ccc3ncc(n3n1)-c1cc(ccn1)CO2	InChI=1S/C19H15N5O/c1-2-4-17-14(3-1)10-21-18-5-6-19-22-11-16(24(19)23-18)15-9-13(12-25-17)7-8-20-15/h1-9,11H,10,12H2,(H,21,23)	KVTHKOQHNQCJDK-UHFFFAOYSA-N	540254	(E)-4-oxa-7-aza-1(3,6)-imidazo[1,2-b]pyridazina-2(2,4)-pyridina-5(1,2)-benzenacycloheptaphane::US20260028352, Example I-6	High affinity nerve growth factor receptor NTRK1 [F589L]			 6.10							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540254	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2119&target=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540254&enzyme=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search			121447424	464925240							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVLEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,8J5W,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238424	CC1Nc2ccc3ncc(n3n2)-c2cncc(c2)COc2ccc(F)cc21	InChI=1S/C20H16FN5O/c1-12-16-7-15(21)2-3-18(16)27-11-13-6-14(9-22-8-13)17-10-23-20-5-4-19(24-12)25-26(17)20/h2-10,12H,11H2,1H3,(H,24,25)	FQNFJPNSYVWSLJ-UHFFFAOYSA-N	540255	(E)-54-fluoro-6-methyl-4-oxa-7-aza-1(3,6)-imidazo[1,2-b]pyridazine-2(3,5)-pyridina-5(1,2)-benzenacycloheptaphane::US20260028352, Example I-7	High affinity nerve growth factor receptor NTRK1 [F589L]			<5.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540255	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2119&target=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540255&enzyme=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search			121447253	464925241							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVLEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,8J5W,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238425	c1ccc2c(c1)CNc1ccc3ncc(n3n1)-c1cncc(c1)CCO2	InChI=1S/C20H17N5O/c1-2-4-18-15(3-1)12-22-19-5-6-20-23-13-17(25(20)24-19)16-9-14(7-8-26-18)10-21-11-16/h1-6,9-11,13H,7-8,12H2,(H,22,24)	VLEUZBIYEHGRBZ-UHFFFAOYSA-N	540256	(E)-6-oxa-3-aza-2(3,6)-imidazo[1,2-b]pyridazina-1(2,4)-pyridina-5(1,2)-benzenacyclooctaphane::US20260028352, Example I-8	High affinity nerve growth factor receptor NTRK1 [F589L]			<5.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540256	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2119&target=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540256&enzyme=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search			121446959	464925242							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVLEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,8J5W,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238426	CC1Nc2ccc3ncc(n3n2)-c2cc(ccn2)CCOc2ccccc21	InChI=1S/C21H19N5O/c1-14-16-4-2-3-5-19(16)27-11-9-15-8-10-22-17(12-15)18-13-23-21-7-6-20(24-14)25-26(18)21/h2-8,10,12-14H,9,11H2,1H3,(H,24,25)	YZTPKLFQYJZQOU-UHFFFAOYSA-N	540257	(E)-4-methyl-6-oxa-3-aza-2(3,6)-imidazo[1,2-b]pyridazina-1(2,4)-pyridina-5(1,2)-benzenacyclooctaphane::US20260028352, Example I-9	High affinity nerve growth factor receptor NTRK1 [F589L]			<5.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540257	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2119&target=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540257&enzyme=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search			121446957	464925243							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVLEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,8J5W,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238427	CC1Nc2ccc3ncc(n3n2)-c2cc(ncn2)COc2ccccc21	InChI=1S/C19H16N6O/c1-12-14-4-2-3-5-17(14)26-10-13-8-15(22-11-21-13)16-9-20-19-7-6-18(23-12)24-25(16)19/h2-9,11-12H,10H2,1H3,(H,23,24)	MNFCCBRZQYYMNF-UHFFFAOYSA-N	540258	(E)-6-methyl-4-oxa-7-aza-1(3,6)-imidazo[1,2-b]pyridazina-2(4,6)-pyrimidine-5(1,2)-benzenacycloheptaphane::US20260028352, Example I-10	High affinity nerve growth factor receptor NTRK1 [F589L]			<5.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540258	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2119&target=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540258&enzyme=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search			121447057	464925244							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVLEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,8J5W,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238428	CC1Nc2ccc3ncc(n3n2)-c2cc(ncn2)CCOc2ccccc21	InChI=1S/C20H18N6O/c1-13-15-4-2-3-5-18(15)27-9-8-14-10-16(23-12-22-14)17-11-21-20-7-6-19(24-13)25-26(17)20/h2-7,10-13H,8-9H2,1H3,(H,24,25)	FATCNTFSENHZBG-UHFFFAOYSA-N	540259	(E)-4-methyl-6-oxa-3-aza-2(3,6)-imidazo[1,2-b]pyridazina-1(4,6)-pyrimidina-5(1,2)-benzenacycloheptaphane::US20260028352, Example I-11	High affinity nerve growth factor receptor NTRK1 [F589L]			<5.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540259	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2119&target=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540259&enzyme=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search			121447254	464925245							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVLEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,8J5W,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238429	CC1Nc2ccc3ncc(n3n2)-c2cc(ccn2)OCc2ncc(F)cc21	InChI=1S/C19H15FN6O/c1-11-14-6-12(20)8-22-16(14)10-27-13-4-5-21-15(7-13)17-9-23-19-3-2-18(24-11)25-26(17)19/h2-9,11H,10H2,1H3,(H,24,25)	WJVMOPOTVOGGPM-UHFFFAOYSA-N	540260	(E)-55-fluoro-6-methyl-3-oxa-7-aza-1(3,6)-imidazo[1,2-b]pyridazina-2(2,4), 5(2,3)-dipyridinacycloheptaphane::US20260028352, Example I-12	High affinity nerve growth factor receptor NTRK1 [F589L]			<5.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540260	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2119&target=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540260&enzyme=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search			121447430	464925246							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVLEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,8J5W,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238430	CC1Nc2ccc3ncc(n3n2)-c2cc(ccn2)OCc2ccc(F)cc21	InChI=1S/C20H16FN5O/c1-12-16-8-14(21)3-2-13(16)11-27-15-6-7-22-17(9-15)18-10-23-20-5-4-19(24-12)25-26(18)20/h2-10,12H,11H2,1H3,(H,24,25)	KLVQBCTUSSQNFS-UHFFFAOYSA-N	540261	(E)-54-fluoro-6-methyl-3-oxa-7-aza-1(3,6)-imidazo[1,2-b]pyridazina-2(2,4)-pyridina-5(1,2)-benzenacycloheptaphane::US20260028352, Example I-13	High affinity nerve growth factor receptor NTRK1 [F589L]			<5.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540261	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2119&target=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540261&enzyme=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search			121446960	464925247							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVLEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,8J5W,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238431	C[C@H]1Nc2ccc3ncc(n3n2)-c2cc(ccn2)COc2ccc(F)cc21	InChI=1S/C20H16FN5O/c1-12-15-9-14(21)2-3-18(15)27-11-13-6-7-22-16(8-13)17-10-23-20-5-4-19(24-12)25-26(17)20/h2-10,12H,11H2,1H3,(H,24,25)	ORCBEAXRXVSMKD-UHFFFAOYSA-N	540262	(R)-(E)-54-fluoro-6-methyl-4-oxa-7-aza-1(3,6)-imidazo[1,2-b]pyridazina-2(2,4)-pyridina-5(1,2)-benzenacycloheptaphane::US20260028352, Example I-14	High affinity nerve growth factor receptor NTRK1 [F589L]			<5.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540262	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2119&target=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540262&enzyme=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search			121447429	464925248							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVLEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,8J5W,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238432	C[C@H]1Nc2ccc3ncc(n3n2)-c2cc(ccn2)COc2c(F)cc(F)cc21	InChI=1S/C20H15F2N5O/c1-11-14-7-13(21)8-15(22)20(14)28-10-12-4-5-23-16(6-12)17-9-24-19-3-2-18(25-11)26-27(17)19/h2-9,11H,10H2,1H3,(H,25,26)	GVUUYSHGOSPJRA-UHFFFAOYSA-N	540264	(R)-(E)-54,56-difluoro-6-methyl-4-oxa-7-aza-1(3,6)-imidazo[1,2-b]pyridazine-2(2,4)-pyridina-5(1,2)-benzenacycloheptaphane::US20260028352, Example I-16	High affinity nerve growth factor receptor NTRK1 [F589L]			<5.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540264	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2119&target=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540264&enzyme=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search			121447289	464925250							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVLEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,8J5W,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238433	C[C@H]1Nc2ccc3ncc(n3n2)-c2cc(ccn2)COc2ccccc21	InChI=1S/C20H17N5O/c1-13-15-4-2-3-5-18(15)26-12-14-8-9-21-16(10-14)17-11-22-20-7-6-19(23-13)24-25(17)20/h2-11,13H,12H2,1H3,(H,23,24)	AAGFEFPZUYTMTD-UHFFFAOYSA-N	540266	(R)-(E)-6-methyl-4-oxa-7-aza-1(3,6)-imidazo[1,2-b]pyridazine-2(2,4)-pyridina-5(1,2)-benzenacycloheptaphane::US20260028352, Example I-18	High affinity nerve growth factor receptor NTRK1 [F589L]			<5.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540266	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2119&target=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540266&enzyme=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search			121447248	464925252							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVLEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,8J5W,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238434	C[C@H]1Nc2ccc3ncc(n3n2)-c2cc(ccn2)COc2ncccc21	InChI=1S/C19H16N6O/c1-12-14-3-2-7-21-19(14)26-11-13-6-8-20-15(9-13)16-10-22-18-5-4-17(23-12)24-25(16)18/h2-10,12H,11H2,1H3,(H,23,24)	SVCHIYVESLEUMG-UHFFFAOYSA-N	540268	(R)-(E)-6-methyl-4-oxa-7-aza-1(3,6)-imidazo[1,2-b]pyridazina-2(2,4), 5(2,3)-dipyridinacycloheptaphane::US20260028352, Example I-20	High affinity nerve growth factor receptor NTRK1 [F589L]			<5.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540268	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2119&target=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540268&enzyme=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search			121447434	464925254							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVLEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,8J5W,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238435	C[C@H]1Nc2ccc3ncc(n3n2)-c2cncc(c2)COc2ccc(F)cc21	InChI=1S/C20H16FN5O/c1-12-16-7-15(21)2-3-18(16)27-11-13-6-14(9-22-8-13)17-10-23-20-5-4-19(24-12)25-26(17)20/h2-10,12H,11H2,1H3,(H,24,25)	FQNFJPNSYVWSLJ-UHFFFAOYSA-N	540270	(R)-(E)-54-fluoro-6-methyl-4-oxa-7-aza-1(3,6)-imidazo[1,2-b]pyridazina-2(3,5)-pyridina-5(1,2)-benzenacycloheptaphane::US20260028352, Example I-22	High affinity nerve growth factor receptor NTRK1 [F589L]			<5.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540270	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2119&target=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540270&enzyme=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search			121447201	464925256							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVLEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,8J5W,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238436	C[C@@H]1Nc2ccc3ncc(n3n2)-c2cncc(c2)OCc2ncc(F)cc21	InChI=1S/C19H15FN6O/c1-11-15-5-13(20)7-22-16(15)10-27-14-4-12(6-21-8-14)17-9-23-19-3-2-18(24-11)25-26(17)19/h2-9,11H,10H2,1H3,(H,24,25)	ACRQYMGHQSIJOJ-UHFFFAOYSA-N	540272	(R)-(E)-55-fluoro-6-methyl-3-oxa-7-aza-1(3,6)-imidazo[1,2-b]pyridazina-2(2,4), 5(2,3)-dipyridinacycloheptaphane::US20260028352, Example I-24	High affinity nerve growth factor receptor NTRK1 [F589L]			<5.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540272	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2119&target=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540272&enzyme=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search			121447302	464925258							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVLEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,8J5W,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238437	C[C@H]1Nc2ccc3ncc(n3n2)-c2cc(ncn2)COc2ccccc21	InChI=1S/C19H16N6O/c1-12-14-4-2-3-5-17(14)26-10-13-8-15(22-11-21-13)16-9-20-19-7-6-18(23-12)24-25(16)19/h2-9,11-12H,10H2,1H3,(H,23,24)	MNFCCBRZQYYMNF-UHFFFAOYSA-N	540274	(R)-(E)-6-methyl-4-oxa-7-aza-1(3,6)-imidazo[1,2-b]pyridazina-2(4,6)-pyrimidina-5(1,2)-benzenacycloheptaphane::US20260028352, Example I-26	High affinity nerve growth factor receptor NTRK1 [F589L]			<5.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540274	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2119&target=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540274&enzyme=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search			121446963	464925260							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVLEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,8J5W,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238438	C[C@@H]1Nc2ccc3ncc(n3n2)-c2cc(ccn2)CCOc2ccc(F)cc21	InChI=1S/C21H18FN5O/c1-13-16-11-15(22)2-3-19(16)28-9-7-14-6-8-23-17(10-14)18-12-24-21-5-4-20(25-13)26-27(18)21/h2-6,8,10-13H,7,9H2,1H3,(H,25,26)	XZENVYVAUNFWEK-UHFFFAOYSA-N	540276	(4R,E)-4-methyl-6-oxa-3-aza-2(3,6)-imidazo[1,2-b]pyridazina-1(2,4)-pyridina-5(1,2)-benzenacyclooctaphane::US20260028352, Example I-28	High affinity nerve growth factor receptor NTRK1 [F589L]			<5.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540276	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2119&target=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540276&enzyme=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search			121447199	464925262							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVLEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,8J5W,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238439	C[C@H]1Nc2ccc3ncc(n3n2)-c2cc(ccn2)OCc2ccc(F)cc21	InChI=1S/C20H16FN5O/c1-12-16-8-14(21)3-2-13(16)11-27-15-6-7-22-17(9-15)18-10-23-20-5-4-19(24-12)25-26(18)20/h2-10,12H,11H2,1H3,(H,24,25)	KLVQBCTUSSQNFS-UHFFFAOYSA-N	540278	(R)-(E)-54-fluoro-6-methyl-3-oxa-7-aza-1(3,6)-imidazo[1,2-b]pyridazina-2(2,4)-pyridina-5(1,2)-benzenacycloheptaphane::US20260028352, Example I-30	High affinity nerve growth factor receptor NTRK1 [F589L]			<5.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540278	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2119&target=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540278&enzyme=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search			121447313	464925264							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVLEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,8J5W,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238440	C[C@H]1Nc2ccc3ncc(n3n2)-c2cc(ncn2)CCOc2ccccc21	InChI=1S/C20H18N6O/c1-13-15-4-2-3-5-18(15)27-9-8-14-10-16(23-12-22-14)17-11-21-20-7-6-19(24-13)25-26(17)20/h2-7,10-13H,8-9H2,1H3,(H,24,25)	FATCNTFSENHZBG-UHFFFAOYSA-N	540280	(R)-(E)-4-methyl-6-oxa-3-aza-2(3,6)-imidazo[1,2-b]pyridazina-1(4,6)-pyrimidina-5(1,2)-benzenacyclooctaphane::US20260028352, Example I-32	High affinity nerve growth factor receptor NTRK1 [F589L]			<5.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540280	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2119&target=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540280&enzyme=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search			121446964	464925266							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVLEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,8J5W,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238441	C[C@@H]1Cc2ccnc(c2)-c2cnc3ccc(nn23)N[C@H](C)c2cc(F)ccc2O1	InChI=1S/C22H20FN5O/c1-13-9-15-7-8-24-18(10-15)19-12-25-22-6-5-21(27-28(19)22)26-14(2)17-11-16(23)3-4-20(17)29-13/h3-8,10-14H,9H2,1-2H3,(H,26,27)	UHDLVVDUXWRCMH-UHFFFAOYSA-N	540282	(4R,7R,E)-55-fluoro-4,7-dimethyl-6-oxa-3-aza-2(3,6)-imidazo[1,2-b]pyridazina-1(2,4)-pyridina-5(1,2)-benzenacyclooctaphane::US20260028352, Example I-34	High affinity nerve growth factor receptor NTRK1 [F589L]			<5.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540282	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2119&target=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540282&enzyme=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search			121446965	464925268							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVLEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,8J5W,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238442	C[C@@H]1Cc2cc(ncn2)-c2cnc3ccc(nn23)N[C@H](C)c2cc(F)ccc2O1	InChI=1S/C21H19FN6O/c1-12-7-15-9-17(25-11-24-15)18-10-23-21-6-5-20(27-28(18)21)26-13(2)16-8-14(22)3-4-19(16)29-12/h3-6,8-13H,7H2,1-2H3,(H,26,27)	ITZDIEFBIHYMSJ-UHFFFAOYSA-N	540283	(4R,7R,E)-5'-fluoro-4,7-dimethyl-6-oxa-3-aza-2(3,6)-imidazo[1,2-b]pyridazina-1(4,6)-pyrimidina-5(1,2)-benzenacyclooctaphane::US20260028352, Example I-35	High affinity nerve growth factor receptor NTRK1 [F589L]			<5.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540283	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2119&target=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540283&enzyme=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search			121447439	464925269							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVLEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,8J5W,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238443	C[C@@H]1Cc2ccnc(c2)-c2cnc3ccc(nn23)N[C@H](C)c2cc(F)cnc2O1	InChI=1S/C21H19FN6O/c1-12-7-14-5-6-23-17(8-14)18-11-24-20-4-3-19(27-28(18)20)26-13(2)16-9-15(22)10-25-21(16)29-12/h3-6,8-13H,7H2,1-2H3,(H,26,27)	ZEWWIZIZHRADBR-UHFFFAOYSA-N	540284	(4R,7R,E)-55-fluoro-4,7-dimethyl-6-oxa-3-aza-2(3,6)-imidazo[1,2-b]pyridazina-1(2,4), 5(3,2)-dipyridinacyclooctaphane::US20260028352, Example I-36	High affinity nerve growth factor receptor NTRK1 [F589L]			<5.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540284	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2119&target=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540284&enzyme=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search			121447290	464925270							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVLEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,8J5W,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238444	C[C@@H]1Cc2ccnc(c2)-c2cnc3ccc(nn23)N2CCC[C@@H]2c2cc(F)ccc2O1	InChI=1S/C24H22FN5O/c1-15-11-16-8-9-26-19(12-16)21-14-27-23-6-7-24(28-30(21)23)29-10-2-3-20(29)18-13-17(25)4-5-22(18)31-15/h4-9,12-15,20H,2-3,10-11H2,1H3	KTUQXYOQECBWRJ-UHFFFAOYSA-N	540285	(32R,6R,E)-45-fluoro-6-methyl-5-oxa-2(3,6)-imidazo[1,2-b]pyridazina-1(2,4)-pyridina-3(1,2)-pyrrolidina-4(1,2)-benzenacycloheptaphane::US20260028352, Example I-37	High affinity nerve growth factor receptor NTRK1 [F589L]			<5.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540285	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2119&target=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540285&enzyme=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search			121447440	464925271							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVLEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,8J5W,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238445	C[C@@H]1Cc2ccnc(c2)-c2cnc3ccc(nn23)N2CCC[C@@H]2c2cc(F)cnc2O1	InChI=1S/C23H21FN6O/c1-14-9-15-6-7-25-18(10-15)20-13-26-21-4-5-22(28-30(20)21)29-8-2-3-19(29)17-11-16(24)12-27-23(17)31-14/h4-7,10-14,19H,2-3,8-9H2,1H3	WFEOFAMMFORTDR-UHFFFAOYSA-N	540286	(32R,6R,E)-45-fluoro-6-methyl-5-oxa-2(3,6)-imidazo[1,2-b]pyridazina-1(2,4), 4(3,2)-dipyridina-3(1,2)-pyrrolidinacycloheptaphane::US20260028352, Example I-38	High affinity nerve growth factor receptor NTRK1 [F589L]			<5.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540286	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2119&target=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540286&enzyme=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search			121447299	464925272							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVLEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,8J5W,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238446	C[C@@H]1Cc2ccnc(c2)-c2cnc3ccc(nn23)N2C[C@@H](F)C[C@@H]2c2cc(F)ccc2O1	InChI=1S/C24H21F2N5O/c1-14-8-15-6-7-27-19(9-15)21-12-28-23-4-5-24(29-31(21)23)30-13-17(26)11-20(30)18-10-16(25)2-3-22(18)32-14/h2-7,9-10,12,14,17,20H,8,11,13H2,1H3	KWCGFNKHVWGYAC-UHFFFAOYSA-N	540287	(32R,34S,6R,E)-34,45-difluoro-6-methyl-5-oxa-2(3,6)-imidazo[1,2-b]pyridazina-1(2,4)-pyridina-3(1,2)-pyrrolidina-4(1,2)-benzenacycloheptaphane::US20260028352, Example I-39	High affinity nerve growth factor receptor NTRK1 [F589L]			<5.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540287	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2119&target=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540287&enzyme=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search			121447204	464925273							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVLEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,8J5W,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238447	C[C@@H]1Cc2ccnc(c2)-c2cnc3ccc(nn23)N2C[C@@H](F)C[C@@H]2c2cc(F)cnc2O1	InChI=1S/C23H20F2N6O/c1-13-6-14-4-5-26-18(7-14)20-11-27-21-2-3-22(29-31(20)21)30-12-16(25)9-19(30)17-8-15(24)10-28-23(17)32-13/h2-5,7-8,10-11,13,16,19H,6,9,12H2,1H3	DAALPXROAURTFB-UHFFFAOYSA-N	540288	(32R,34S,6R,E)-34,45-difluoro-6-methyl-5-oxa-2(3,6)-imidazo[1,2-b]pyridazina-1(2,4),4(3,2)-dipyridina-3(1,2)-pyrrolidinacycloheptaphane::US20260028352, Example I-40	High affinity nerve growth factor receptor NTRK1 [F589L]			<5.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540288	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2119&target=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540288&enzyme=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search			121447239	464925274							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVLEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,8J5W,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238448	C[C@H]1Nc2ccc3ncc(n3n2)-c2cc(ccn2)N2CC[C@H](C2)Oc2ccc(F)cc21	InChI=1S/C23H21FN6O/c1-14-18-10-15(24)2-3-21(18)31-17-7-9-29(13-17)16-6-8-25-19(11-16)20-12-26-23-5-4-22(27-14)28-30(20)23/h2-6,8,10-12,14,17H,7,9,13H2,1H3,(H,27,28)	DOOASRFGZIHKNC-UHFFFAOYSA-N	540289	(33R,6R,E)-54-fluoro-6-methyl-4-oxa-7-aza-1(3,6)-imidazo[1,2-b]pyridazina-2(2,4)-pyridina-3(1,3)-pyrrolidina-5(1,2)-benzenacycloheptaphane::US20260028352, Example I-41	High affinity nerve growth factor receptor NTRK1 [F589L]			<5.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540289	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2119&target=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540289&enzyme=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search			121447297	464925275							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVLEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,8J5W,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238449	C[C@H]1Nc2ccc3ncc(n3n2)-c2cc(ccn2)N2CC[C@@H](C2)Oc2ccc(F)cc21	InChI=1S/C23H21FN6O/c1-14-18-10-15(24)2-3-21(18)31-17-7-9-29(13-17)16-6-8-25-19(11-16)20-12-26-23-5-4-22(27-14)28-30(20)23/h2-6,8,10-12,14,17H,7,9,13H2,1H3,(H,27,28)	DOOASRFGZIHKNC-UHFFFAOYSA-N	540290	(33S,6R,E)-54-fluoro-6-methyl-4-oxa-7-aza-1(3,6)-imidazo[1,2-b]pyridazina-2(2,4)-pyridina-3(1,3)-pyrrolidina-5(1,2)-benzenacycloheptaphane::US20260028352, Example I-42	High affinity nerve growth factor receptor NTRK1 [F589L]			<5.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540290	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2119&target=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540290&enzyme=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search			121446966	464925276							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVLEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,8J5W,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238450	C[C@H]1Nc2ccc3ncc(n3n2)-c2cc(ccn2)N2CCC[C@H](C2)Oc2ccc(F)cc21	InChI=1S/C24H23FN6O/c1-15-19-11-16(25)4-5-22(19)32-18-3-2-10-30(14-18)17-8-9-26-20(12-17)21-13-27-24-7-6-23(28-15)29-31(21)24/h4-9,11-13,15,18H,2-3,10,14H2,1H3,(H,28,29)	ZUACUTCXZIRTPG-UHFFFAOYSA-N	540291	(33R,6R,E)-54-fluoro-6-methyl-4-oxa-7-aza-1(3,6)-imidazo[1,2-b]pyridazina-2(2,4)-pyridina-3(1,3)-piperidina-5(1,2)-benzenacycloheptaphane::US20260028352, Example I-43	High affinity nerve growth factor receptor NTRK1 [F589L]			<5.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540291	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2119&target=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540291&enzyme=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search			121447438	464925277							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVLEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,8J5W,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238451	C[C@H]1Nc2ccc3ncc(n3n2)-c2cc(ccn2)N2CCC[C@@H](C2)Oc2ccc(F)cc21	InChI=1S/C24H23FN6O/c1-15-19-11-16(25)4-5-22(19)32-18-3-2-10-30(14-18)17-8-9-26-20(12-17)21-13-27-24-7-6-23(28-15)29-31(21)24/h4-9,11-13,15,18H,2-3,10,14H2,1H3,(H,28,29)	ZUACUTCXZIRTPG-UHFFFAOYSA-N	540292	(33S,6R,E)-54-fluoro-6-methyl-4-oxa-7-aza-1(3,6)-imidazo[1,2-b]pyridazina-2(2,4)-pyridina-3(1,3)-piperidina-5(1,2)-benzenacycloheptaphane::US20260028352, Example I-44	High affinity nerve growth factor receptor NTRK1 [F589L]			<5.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540292	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2119&target=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540292&enzyme=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search			121447068	464925278							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVLEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,8J5W,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238452	Fc1ccc2c(c1)[C@H]1CCCN1c1ccc3ncc(n3n1)-c1cc(ccn1)[C@H]1CCC[C@H]1O2	InChI=1S/C26H24FN5O/c27-17-6-7-24-19(14-17)21-4-2-12-31(21)26-9-8-25-29-15-22(32(25)30-26)20-13-16(10-11-28-20)18-3-1-5-23(18)33-24/h6-11,13-15,18,21,23H,1-5,12H2	SIEFKSAYOODFKQ-UHFFFAOYSA-N	540293	(8aR,11aR,16bR,E)-15-fluoro-8a,10,11,11a,16b,17,18,19-octahydro-9H-1,21-etheno-4,8-(metheno)benzo[b]cyclopenta[o]imidazo[1,5-h]pyrrolo[2,1-d][1]oxa[5,7,8,11]tetraazacyclohexadecine::US20260028352, Example I-45	High affinity nerve growth factor receptor NTRK1 [F589L]			<5.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540293	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2119&target=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540293&enzyme=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search			121447300	464925279							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVLEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,8J5W,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238453	Fc1ccc2c(c1)[C@H]1CCCN1c1ccc3ncc(n3n1)-c1cc(ccn1)[C@@H]1CCC[C@H]1O2	InChI=1S/C26H24FN5O/c27-17-6-7-24-19(14-17)21-4-2-12-31(21)26-9-8-25-29-15-22(32(25)30-26)20-13-16(10-11-28-20)18-3-1-5-23(18)33-24/h6-11,13-15,18,21,23H,1-5,12H2	SIEFKSAYOODFKQ-UHFFFAOYSA-N	540294	(8aS,11aR,16bR,E)-15-fluoro-8a,10,11,11a,16b,17,18,19-octahydro-9H-1,21-etheno-4,8-(metheno)benzo[b]cyclopenta[o]imidazo[1,5-h]pyrrolo[2,1-d][1]oxa[5,7,8,11]tetraazacyclohexadecine::US20260028352, Example I-46	High affinity nerve growth factor receptor NTRK1 [F589L]			<5.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540294	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2119&target=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540294&enzyme=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search			121447071	464925280							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVLEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,8J5W,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238454	Fc1ccc2c(c1)C1(CC1)Nc1ccc3ncc(n3n1)-c1cc(ccn1)CO2	InChI=1S/C21H16FN5O/c22-14-1-2-18-15(10-14)21(6-7-21)25-19-3-4-20-24-11-17(27(20)26-19)16-9-13(12-28-18)5-8-23-16/h1-5,8-11H,6-7,12H2,(H,25,26)	VDZVFKWNVUDGBV-UHFFFAOYSA-N	540295	(E)-4'-fluorospiro[cyclopropane-1,6'-4-oxa-7-aza-1(3,6)-imidazo[1,2-b]pyridazina-2(2,4)-pyridina-5(1,2)-benzenacycloheptaphane]::US20260028352, Example I-47	High affinity nerve growth factor receptor NTRK1 [F589L]			<5.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540295	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2119&target=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540295&enzyme=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search			121447309	464925281							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVLEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,8J5W,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238455	CC1(C)Nc2ccc3ncc(n3n2)-c2cc(ccn2)COc2ccc(F)cc21	InChI=1S/C21H18FN5O/c1-21(2)15-10-14(22)3-4-18(15)28-12-13-7-8-23-16(9-13)17-11-24-20-6-5-19(25-21)26-27(17)20/h3-11H,12H2,1-2H3,(H,25,26)	QDCJOYWQNFJRGW-UHFFFAOYSA-N	540296	(E)-54-fluoro-6,6-dimethyl-4-oxa-7-aza-1(3,6)-imidazo[1,2-b]pyridazina-2(2,4)-pyridina-5(1,2)-benzenacycloheptaphane::US20260028352, Example I-48	High affinity nerve growth factor receptor NTRK1 [F589L]			<5.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540296	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2119&target=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540296&enzyme=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search			121447255	464925282							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVLEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,8J5W,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238456	Fc1ccc2c(c1)[C@H]1C[C@H](F)CN1c1ccc3ncc(n3n1)-c1cc(ccn1)CO2	InChI=1S/C22H17F2N5O/c23-14-1-2-20-16(8-14)18-9-15(24)11-28(18)22-4-3-21-26-10-19(29(21)27-22)17-7-13(12-30-20)5-6-25-17/h1-8,10,15,18H,9,11-12H2	BINSPWKXEAOPRH-UHFFFAOYSA-N	540297	(14bR,E)-13-fluoro-14b,15,16,17-tetrahydro-9H-1,19-etheno-4,8-(metheno) benzo[b]imidazo[1,5-h]pyrrolo[2,1-d][1]oxa[5,7,8,11]tetraazacyclopentadecine::US20260028352, Example I-49	High affinity nerve growth factor receptor NTRK1 [F589L]			<5.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540297	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2119&target=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540297&enzyme=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search			121446968	464925283							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVLEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,8J5W,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238457	Fc1ccc2c(c1)[C@H]1C[C@H](F)CN1c1ccc3ncc(n3n1)-c1cc(ccn1)CO2	InChI=1S/C22H17F2N5O/c23-14-1-2-20-16(8-14)18-9-15(24)11-28(18)22-4-3-21-26-10-19(29(21)27-22)17-7-13(12-30-20)5-6-25-17/h1-8,10,15,18H,9,11-12H2	BINSPWKXEAOPRH-UHFFFAOYSA-N	540298	(14bR,16S,E)-13,16-difluoro-14b,15,16,17-tetrahydro-9H-1,19-etheno-4,8-(metheno)benzo[b]imidazo[1,5-h]pyrrolo[2,1-d][1]oxa[5,7,8,11]tetraazacyclopentadecine::US20260028352, Example I-50	High affinity nerve growth factor receptor NTRK1 [F589L]			<5.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540298	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2119&target=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540298&enzyme=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search			121447312	464925284							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVLEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,8J5W,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238458	Fc1cnc2c(c1)[C@H]1CCCN1c1ccc3ncc(n3n1)-c1cc(ccn1)CO2	InChI=1S/C21H17FN6O/c22-14-9-15-17-2-1-7-27(17)20-4-3-19-24-11-18(28(19)26-20)16-8-13(5-6-23-16)12-29-21(15)25-10-14/h3-6,8-11,17H,1-2,7,12H2	ONRFCQNOCUWSRL-UHFFFAOYSA-N	540299	(14bR,E)-13-fluoro-14b,15,16,17-tetrahydro-9H-1,19-etheno-4,8-(metheno) imidazo[1,5-h]pyrido[2,3-b]pyrrolo[2,1-d][1]oxa[5,7,8,11]tetraazacyclopentadecine::US20260028352, Example I-51	High affinity nerve growth factor receptor NTRK1 [F589L]			<5.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540299	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2119&target=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540299&enzyme=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search			121446971	464925285							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVLEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,8J5W,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238459	Fc1cnc2c(c1)[C@H]1C[C@H](F)CN1c1ccc3ncc(n3n1)-c1cc(ncn1)CO2	InChI=1S/C20H15F2N7O/c21-11-3-14-16-4-12(22)8-28(16)19-2-1-18-23-7-17(29(18)27-19)15-5-13(25-10-26-15)9-30-20(14)24-6-11/h1-3,5-7,10,12,16H,4,8-9H2	ZMAVQOXFKKHZNV-UHFFFAOYSA-N	540300	(14bR,16S,E)-13,16-difluoro-14b,15,16,17-tetrahydro-9H-1,19-etheno-4,8-(metheno)imidazo[1,5-h]pyrido[2,3-b]pyrrolo[2,1-d][1]oxa[5,7,8,11]tetraazacyclopentadecine::US20260028352, Example I-52	High affinity nerve growth factor receptor NTRK1 [F589L]			<5.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540300	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2119&target=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540300&enzyme=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search			121447275	464925286							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVLEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,8J5W,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238460	Fc1ccc2c(c1)[C@H]1CCCN1c1ccc3ncc(n3n1)-c1cc(ccn1)CCO2	InChI=1S/C23H20FN5O/c24-16-3-4-21-17(13-16)19-2-1-10-28(19)23-6-5-22-26-14-20(29(22)27-23)18-12-15(7-9-25-18)8-11-30-21/h3-7,9,12-14,19H,1-2,8,10-11H2	VIEWTTLKGSUVTD-UHFFFAOYSA-N	540301	(32R,E)-45-fluoro-5-oxa-2(3,6)-imidazo[1,2-b]pyridazina-1(2,4)-pyridina-3(1,2)-pyrrolidina-4(1,2)-benzenacycloheptaphane::US20260028352, Example I-53	High affinity nerve growth factor receptor NTRK1 [F589L]			<5.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540301	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2119&target=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540301&enzyme=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search			121446972	464925287							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVLEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,8J5W,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238461	Fc1cnc2c(c1)[C@H]1C[C@H](F)CN1c1ccc3ncc(n3n1)-c1cc(ccn1)CCO2	InChI=1S/C22H18F2N6O/c23-14-8-16-18-9-15(24)12-29(18)21-2-1-20-26-11-19(30(20)28-21)17-7-13(3-5-25-17)4-6-31-22(16)27-10-14/h1-3,5,7-8,10-11,15,18H,4,6,9,12H2	MLQXYJATWUNBGZ-UHFFFAOYSA-N	540302	(32R,34S,E)-34,45-difluoro-5-oxa-2(3,6)-imidazo[1,2-b]pyridazina-1(2,4)-pyridina-3(1,2)-pyrrolidina-4(1,2)-benzenacycloheptaphane::US20260028352, Example I-54	High affinity nerve growth factor receptor NTRK1 [F589L]			<5.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540302	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2119&target=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540302&enzyme=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search			121447069	464925288							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVLEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,8J5W,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238462	Fc1cnc2c(c1)[C@H]1CCCN1c1ccc3ncc(n3n1)-c1cc(ccn1)CCO2	InChI=1S/C22H19FN6O/c23-15-11-16-18-2-1-8-28(18)21-4-3-20-25-13-19(29(20)27-21)17-10-14(5-7-24-17)6-9-30-22(16)26-12-15/h3-5,7,10-13,18H,1-2,6,8-9H2	KQFMPZZXZZTNBZ-UHFFFAOYSA-N	540303	(32R,E)-45-fluoro-5-oxa-2(3,6)-imidazo[1,2-b]pyridazina-1(2,4),4(3,2)-dipyridina-3(1,2)-pyrrolidinacycloheptaphane::US20260028352, Example I-55	High affinity nerve growth factor receptor NTRK1 [F589L]			<5.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540303	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2119&target=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540303&enzyme=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search			121447441	464925289							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVLEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,8J5W,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238463	Fc1ccc2c(c1)[C@H]1C[C@H](F)CN1c1ccc3ncc(n3n1)-c1cc(ccn1)CCO2	InChI=1S/C23H19F2N5O/c24-15-1-2-21-17(10-15)19-11-16(25)13-29(19)23-4-3-22-27-12-20(30(22)28-23)18-9-14(5-7-26-18)6-8-31-21/h1-5,7,9-10,12,16,19H,6,8,11,13H2	MAIDULXPIOZNTL-UHFFFAOYSA-N	540304	(32R,34S,E)-34,45-difluoro-5-oxa-2(3,6)-imidazo[1,2-b]pyridazina-1(2,4),4(3,2)-dipyridina-3(1,2)-pyrrolidinacycloheptaphane::US20260028352, Example I-56	High affinity nerve growth factor receptor NTRK1 [F589L]			<5.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540304	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2119&target=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540304&enzyme=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search			121446973	464925290							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVLEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,8J5W,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238464	Fc1ccc2c(c1)[C@H]1CCCN1c1ccc3ncc(n3n1)-c1cc(ncn1)CO2	InChI=1S/C21H17FN6O/c22-13-3-4-19-15(8-13)17-2-1-7-27(17)21-6-5-20-23-10-18(28(20)26-21)16-9-14(11-29-19)24-12-25-16/h3-6,8-10,12,17H,1-2,7,11H2	OIYDYBOYIUGROP-UHFFFAOYSA-N	540305	(14bR,E)-13-fluoro-14b,15,16,17-tetrahydro-9H-1,19-etheno-4,8-(metheno) benzo[n]imidazo[5,1-h]pyrrolo[1,2-l][1]oxa[4,6,9,10,12]pentaazacyclopentadecine::US20260028352, Example I-57	High affinity nerve growth factor receptor NTRK1 [F589L]			<5.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540305	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2119&target=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540305&enzyme=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search			121447073	464925291							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVLEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,8J5W,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238465	Fc1ccc2c(c1)[C@H]1C[C@H](F)CN1c1ccc3ncc(n3n1)-c1cc(ncn1)CO2	InChI=1S/C21H16F2N6O/c22-12-1-2-19-15(5-12)17-6-13(23)9-28(17)21-4-3-20-24-8-18(29(20)27-21)16-7-14(10-30-19)25-11-26-16/h1-5,7-8,11,13,17H,6,9-10H2	MZAYDDDYQCACRD-UHFFFAOYSA-N	540306	(14bR,16S,E)-13,16-difluoro-14b,15,16,17-tetrahydro-9H-1,19-etheno-4,8-(metheno)benzo[n]imidazo[5,1-h]pyrrolo[1,2-l][1]oxa[4,6,9,10,12]pentaazacyclopentadecine::US20260028352, Example I-58	High affinity nerve growth factor receptor NTRK1 [F589L]			<5.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540306	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2119&target=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540306&enzyme=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search			121447339	464925292							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVLEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,8J5W,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238466	Fc1cnc2c(c1)[C@H]1CCCN1c1ccc3ncc(n3n1)-c1cc(ncn1)CO2	InChI=1S/C20H16FN7O/c21-12-6-14-16-2-1-5-27(16)19-4-3-18-22-9-17(28(18)26-19)15-7-13(24-11-25-15)10-29-20(14)23-8-12/h3-4,6-9,11,16H,1-2,5,10H2	PXUOTBWWSVWXDX-UHFFFAOYSA-N	540307	(14bR,E)-13-fluoro-14b,15,16,17-tetrahydro-9H-1,19-etheno-4,8-(metheno)imidazo[5,1-h]pyrido[3,2-n]pyrrolo[1,2-l][1]oxa[4,6,9,10,12]pentaazacyclopentadecine::US20260028352, Example I-59	High affinity nerve growth factor receptor NTRK1 [F589L]			<5.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540307	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2119&target=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540307&enzyme=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search			121447322	464925293							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVLEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,8J5W,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238467	Fc1cnc2c(c1)[C@H]1C[C@H](F)CN1c1ccc3ncc(n3n1)-c1cc(ccn1)CO2	InChI=1S/C21H16F2N6O/c22-13-6-15-17-7-14(23)10-28(17)20-2-1-19-25-9-18(29(19)27-20)16-5-12(3-4-24-16)11-30-21(15)26-8-13/h1-6,8-9,14,17H,7,10-11H2	ZPJQJHCYCLMWCW-UHFFFAOYSA-N	540308	(14bR,16S,E)-13,16-difluoro-14b,15,16,17-tetrahydro-9H-1,19-etheno-4,8-(metheno)imidazo[5,1-h]pyrido[3,2-n]pyrrolo[1,2-l][1]oxa[4,6,9,10,12]pentaazacyclopentadecine::US20260028352, Example I-60	High affinity nerve growth factor receptor NTRK1 [F589L]			<5.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540308	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2119&target=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540308&enzyme=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search			121447075	464925294							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVLEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,8J5W,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238468	Fc1ccc2c(c1)[C@H]1CCCN1c1ccc3ncc(n3n1)-c1nccc(n1)CO2	InChI=1S/C21H17FN6O/c22-13-3-4-18-15(10-13)16-2-1-9-27(16)20-6-5-19-24-11-17(28(19)26-20)21-23-8-7-14(25-21)12-29-18/h3-8,10-11,16H,1-2,9,12H2	FCEQQGRAAZAMDF-UHFFFAOYSA-N	540309	(14bR,E)-13-fluoro-14b,15,16,17-tetrahydro-9H-4,8-(azeno)-1,19-etheno benzo[b]imidazo[1,5-h]pyrrolo[2,1-d][1]oxa[5,7,8,11]tetraazacyclopentadecine::US20260028352, Example I-61	High affinity nerve growth factor receptor NTRK1 [F589L]			<5.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540309	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2119&target=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540309&enzyme=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search			121447318	464925295							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVLEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,8J5W,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238469	Fc1cnc2c(c1)[C@H]1C[C@H](F)CN1c1ccc3ncc(n3n1)-c1cc(cnn1)CO2	InChI=1S/C20H15F2N7O/c21-12-4-14-16-5-13(22)9-28(16)19-2-1-18-23-8-17(29(18)27-19)15-3-11(6-25-26-15)10-30-20(14)24-7-12/h1-4,6-8,13,16H,5,9-10H2	ATYILKQOWBVURP-UHFFFAOYSA-N	540310	(14bR,16S,E)-13,16-difluoro-14b,15,16,17-tetrahydro-9H-4,8-(azeno)-1,19-ethenobenzo[b]imidazo[1,5-h]pyrrolo[2,1-d][1]oxa[5,7,8,11]tetraazacyclopentadecine::US20260028352, Example I-62	High affinity nerve growth factor receptor NTRK1 [F589L]			<5.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540310	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2119&target=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540310&enzyme=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search			121447343	464925296							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVLEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,8J5W,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238470	Fc1cnc2c(c1)[C@H]1CCCN1c1ccc3ncc(n3n1)-c1nccc(n1)CO2	InChI=1S/C20H16FN7O/c21-12-8-14-15-2-1-7-27(15)18-4-3-17-23-10-16(28(17)26-18)19-22-6-5-13(25-19)11-29-20(14)24-9-12/h3-6,8-10,15H,1-2,7,11H2	UNUMGPSAYSQYBE-UHFFFAOYSA-N	540311	(14bR,E)-13-fluoro-14b,15,16,17-tetrahydro-9H-4,8-(azeno)-1,19-etheno imidazo[1,5-h]pyrido[2,3-b]pyrrolo[2,1-d][1]oxa[5,7,8,11]tetraazacyclopentadecine::US20260028352, Example I-63	High affinity nerve growth factor receptor NTRK1 [F589L]			<5.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540311	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2119&target=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540311&enzyme=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search			121447205	464925297							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVLEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,8J5W,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238471	Fc1cnc2c(c1)[C@H]1C[C@H](F)CN1c1ccc3ncc(n3n1)-c1nccc(n1)CO2	InChI=1S/C20H15F2N7O/c21-11-5-14-15-6-12(22)9-28(15)18-2-1-17-24-8-16(29(17)27-18)19-23-4-3-13(26-19)10-30-20(14)25-7-11/h1-5,7-8,12,15H,6,9-10H2	LJYVKGCQLRGKIB-UHFFFAOYSA-N	540312	(14bR,16S,E)-13,16-difluoro-14b,15,16,17-tetrahydro-9H-4,8-(azeno)-1,19-ethenoimidazo[1,5-h]pyrido[2,3-b]pyrrolo[2,1-d][1]oxa[5,7,8,11]tetraazacyclopentadecine::US20260028352, Example I-64	High affinity nerve growth factor receptor NTRK1 [F589L]			<5.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540312	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2119&target=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540312&enzyme=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search			121446969	464925298							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVLEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,8J5W,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238472	Fc1ccc2c(c1)[C@H]1CCCN1c1ccc3ncc(n3n1)-c1cc(cnn1)CO2	InChI=1S/C21H17FN6O/c22-14-3-4-19-15(9-14)17-2-1-7-27(17)21-6-5-20-23-11-18(28(20)26-21)16-8-13(12-29-19)10-24-25-16/h3-6,8-11,17H,1-2,7,12H2	CQNYEEZABCEQOT-UHFFFAOYSA-N	540313	(14bR,E)-13-fluoro-14b,15,16,17-tetrahydro-9H-1,19-etheno-4,8-(metheno) benzo[n]imidazo[5,1-h]pyrrolo[1,2-l][1]oxa[5,6,9,10,12]pentaazacyclopentadecine::US20260028352, Example I-65	High affinity nerve growth factor receptor NTRK1 [F589L]			<5.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540313	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2119&target=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540313&enzyme=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search			121446974	464925299							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVLEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,8J5W,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238473	Fc1ccc2c(c1)[C@H]1C[C@H](F)CN1c1ccc3ncc(n3n1)-c1nccc(n1)CO2	InChI=1S/C21H16F2N6O/c22-12-1-2-18-15(7-12)16-8-13(23)10-28(16)20-4-3-19-25-9-17(29(19)27-20)21-24-6-5-14(26-21)11-30-18/h1-7,9,13,16H,8,10-11H2	DFIOTNNBLLFSRF-UHFFFAOYSA-N	540314	(14bR,16S,E)-13,16-difluoro-14b,15,16,17-tetrahydro-9H-1,19-etheno-4,8-(metheno)benzo[n]imidazo[5,1-h]pyrrolo[1,2-l][1]oxa[5,6,9,10,12]pentaazacyclopentadecine::US20260028352, Example I-66	High affinity nerve growth factor receptor NTRK1 [F589L]			<5.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540314	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2119&target=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540314&enzyme=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search			121447077	464925300							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVLEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,8J5W,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238474	Fc1cnc2c(c1)[C@H]1CCCN1c1ccc3ncc(n3n1)-c1cc(cnn1)CO2	InChI=1S/C20H16FN7O/c21-13-7-14-16-2-1-5-27(16)19-4-3-18-22-10-17(28(18)26-19)15-6-12(8-24-25-15)11-29-20(14)23-9-13/h3-4,6-10,16H,1-2,5,11H2	WWKFZRNWDBCJCY-UHFFFAOYSA-N	540315	(14bR,E)-13-fluoro-14b,15,16,17-tetrahydro-9H-1,19-etheno-4,8-(metheno) imidazo[5,1-h]pyrido[3,2-n]pyrrolo[1,2-l][1]oxa[5,6,9,10,12]pentaazacyclopentadecine::US20260028352, Example I-67	High affinity nerve growth factor receptor NTRK1 [F589L]			<5.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540315	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2119&target=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540315&enzyme=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search			121446975	464925301							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVLEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,8J5W,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238475	Fc1ccc2c(c1)[C@H]1C[C@H](F)CN1c1ccc3ncc(n3n1)-c1cc(cnn1)CO2	InChI=1S/C21H16F2N6O/c22-13-1-2-19-15(6-13)17-7-14(23)10-28(17)21-4-3-20-24-9-18(29(20)27-21)16-5-12(11-30-19)8-25-26-16/h1-6,8-9,14,17H,7,10-11H2	LEDGGLVDWQTARF-UHFFFAOYSA-N	540316	(14bR,16S,E)-13,16-difluoro-14b,15,16,17-tetrahydro-9H-1,19-etheno-4,8-(metheno)imidazo[5,1-h]pyrido[3,2-n]pyrrolo[1,2-l][1]oxa[5,6,9,10,12]pentaazacyclopentadecine::US20260028352, Example I-68	High affinity nerve growth factor receptor NTRK1 [F589L]			<5.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540316	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2119&target=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540316&enzyme=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search			121447445	464925302							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVLEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,8J5W,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238476	Fc1ccc2c(c1)[C@H]1CCCN1c1ccc3ncc(n3n1)-c1cc(ncn1)CO2	InChI=1S/C21H17FN6O/c22-13-3-4-19-15(8-13)17-2-1-7-27(17)21-6-5-20-23-10-18(28(20)26-21)16-9-14(11-29-19)24-12-25-16/h3-6,8-10,12,17H,1-2,7,11H2	OIYDYBOYIUGROP-UHFFFAOYSA-N	540317	(32R,E)-45-fluoro-5-oxa-2(3,6)-imidazo[1,2-b]pyridazina-1(4,6)-pyrimidina-3(1,2)-pyrrolidina-4(1,2)-benzenacycloheptaphane::US20260028352, Example I-69	High affinity nerve growth factor receptor NTRK1 [F589L]			<5.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540317	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2119&target=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540317&enzyme=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search			121447085	464925303							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVLEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,8J5W,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238477	Fc1ccc2c(c1)[C@H]1C[C@H](F)CN1c1ccc3ncc(n3n1)-c1cc(ncn1)CCO2	InChI=1S/C22H18F2N6O/c23-13-1-2-20-16(7-13)18-8-14(24)11-29(18)22-4-3-21-25-10-19(30(21)28-22)17-9-15(5-6-31-20)26-12-27-17/h1-4,7,9-10,12,14,18H,5-6,8,11H2	WHLUHJOHEFPOHI-UHFFFAOYSA-N	540318	(32R,34S,E)-34,45-difluoro-5-oxa-2(3,6)-imidazo[1,2-b]pyridazina-1(4,6)-pyrimidina-3(1,2)-pyrrolidina-4(1,2)-benzenacycloheptaphane::US20260028352, Example I-70	High affinity nerve growth factor receptor NTRK1 [F589L]			<5.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540318	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2119&target=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540318&enzyme=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search			121446976	464925304							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVLEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,8J5W,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238478	Fc1cnc2c(c1)[C@H]1CCCN1c1ccc3ncc(n3n1)-c1cc(ncn1)CCO2	InChI=1S/C21H18FN7O/c22-13-8-15-17-2-1-6-28(17)20-4-3-19-23-11-18(29(19)27-20)16-9-14(25-12-26-16)5-7-30-21(15)24-10-13/h3-4,8-12,17H,1-2,5-7H2	WLZWOPAABXIFFV-UHFFFAOYSA-N	540319	(32R,E)-45-fluoro-5-oxa-2(3,6)-imidazo[1,2-b]pyridazina-1(4,6)-pyrimidina-4(3,2)-pyridina-3(1,2)-pyrrolidinacycloheptaphane::US20260028352, Example I-71	High affinity nerve growth factor receptor NTRK1 [F589L]			<5.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540319	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2119&target=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540319&enzyme=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search			121447098	464925305							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVLEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,8J5W,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238479	Fc1cnc2c(c1)[C@H]1C[C@H](F)CN1c1ccc3ncc(n3n1)-c1cc(ncn1)CCO2	InChI=1S/C21H17F2N7O/c22-12-5-15-17-6-13(23)10-29(17)20-2-1-19-24-9-18(30(19)28-20)16-7-14(26-11-27-16)3-4-31-21(15)25-8-12/h1-2,5,7-9,11,13,17H,3-4,6,10H2	CUULFGGGQZBVCS-UHFFFAOYSA-N	540320	(32R,34S,E)-34,45-difluoro-5-oxa-2(3,6)-imidazo[1,2-b]pyridazina-1(4,6)-pyrimidina-4(3,2)-pyridina-3(1,2)-pyrrolidinacycloheptaphane::US20260028352, Example I-72	High affinity nerve growth factor receptor NTRK1 [F589L]			<5.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540320	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2119&target=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540320&enzyme=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search			121447332	464925306							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVLEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,8J5W,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238480	C[C@H]1Nc2ccc3ncc(n3n2)-c2cc(ncn2)CCOc2ncc(F)cc21	InChI=1S/C19H16FN7O/c1-11-14-6-12(20)8-22-19(14)28-5-4-13-7-15(24-10-23-13)16-9-21-18-3-2-17(25-11)26-27(16)18/h2-3,6-11H,4-5H2,1H3,(H,25,26)	FBPVDMBEPUUANT-UHFFFAOYSA-N	540321	(4R,E)-5'-fluoro-4-methyl-6-oxa-3-aza-2(3,6)-imidazo[1,2-b]pyridazina-1(4,6)-pyrimidina-5(3,2)-pyridinacyclooctaphane::US20260028352, Example I-73	High affinity nerve growth factor receptor NTRK1 [F589L]			<5.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540321	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2119&target=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540321&enzyme=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search			121447335	464925307							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVLEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,8J5W,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238481	C[C@H]1Nc2ccc3ncc(n3n2)-c2cc(ncn2)CCOc2ccc(F)cc21	InChI=1S/C20H17FN6O/c1-12-15-8-13(21)2-3-18(15)28-7-6-14-9-16(24-11-23-14)17-10-22-20-5-4-19(25-12)26-27(17)20/h2-5,8-12H,6-7H2,1H3,(H,25,26)	WHBFUIBQLJAOBJ-UHFFFAOYSA-N	540322	(4R,E)-5'-fluoro-4-methyl-6-oxa-3-aza-2(3,6)-imidazo[1,2-b]pyridazina-1(4,6)-pyrimidina-5(1,2)-benzenacyclooctaphane::US20260028352, Example I-74	High affinity nerve growth factor receptor NTRK1 [F589L]			<5.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540322	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2119&target=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540322&enzyme=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search			121446977	464925308							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVLEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,8J5W,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238482	C[C@H]1Nc2ccc3ncc(n3n2)-c2cc(ccn2)CCOc2ncc(F)cc21	InChI=1S/C20H17FN6O/c1-12-15-9-14(21)10-24-20(15)28-7-5-13-4-6-22-16(8-13)17-11-23-19-3-2-18(25-12)26-27(17)19/h2-4,6,8-12H,5,7H2,1H3,(H,25,26)	AGLVDSNFFPPJKF-UHFFFAOYSA-N	540323	(4R,E)-55-fluoro-4-methyl-6-oxa-3-aza-2(3,6)-imidazo[1,2-b]pyridazina-1(2,4), 5(3,2)-dipyridinacyclooctaphane::US20260028352, Example I-75	High affinity nerve growth factor receptor NTRK1 [F589L]			<5.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540323	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2119&target=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540323&enzyme=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search			121447342	464925309							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVLEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,8J5W,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238483	C[C@H]1Nc2ccc3ncc(n3n2)-c2cc(ccn2)CCOc2ccc(F)cc21	InChI=1S/C21H18FN5O/c1-13-16-11-15(22)2-3-19(16)28-9-7-14-6-8-23-17(10-14)18-12-24-21-5-4-20(25-13)26-27(18)21/h2-6,8,10-13H,7,9H2,1H3,(H,25,26)	XZENVYVAUNFWEK-UHFFFAOYSA-N	540324	(4R,E)-5'-fluoro-4-methyl-6-oxa-3-aza-2(3,6)-imidazo[1,2-b]pyridazina-1(2,4)-pyridina-5(1,2)-benzenacyclooctaphane::US20260028352, Example I-76	High affinity nerve growth factor receptor NTRK1 [F589L]			<5.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540324	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2119&target=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540324&enzyme=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search			121447388	464925310							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVLEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,8J5W,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238484	C[C@H]1Nc2ccc3ncc(n3n2)-c2cc(ncn2)COc2ncc(F)cc21	InChI=1S/C18H14FN7O/c1-10-13-4-11(19)6-21-18(13)27-8-12-5-14(23-9-22-12)15-7-20-17-3-2-16(24-10)25-26(15)17/h2-7,9-10H,8H2,1H3,(H,24,25)	UCZSCXRKHPPSHQ-UHFFFAOYSA-N	540325	(6R,E)-55-fluoro-6-methyl-4-oxa-7-aza-1(3,6)-imidazo[1,2-b]pyridazina-2(4,6)-pyrimidina-5(2,3)-pyridinacycloheptaphane::US20260028352, Example I-77	High affinity nerve growth factor receptor NTRK1 [F589L]			<5.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540325	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2119&target=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540325&enzyme=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search			121447449	464925311							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVLEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,8J5W,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238485	C[C@H]1Nc2ccc3ncc(n3n2)-c2cc(ncn2)COc2ccc(F)cc21	InChI=1S/C19H15FN6O/c1-11-14-6-12(20)2-3-17(14)27-9-13-7-15(23-10-22-13)16-8-21-19-5-4-18(24-11)25-26(16)19/h2-8,10-11H,9H2,1H3,(H,24,25)	AGEWFHRKAPCCTC-UHFFFAOYSA-N	540326	(6R,E)-54-fluoro-6-methyl-4-oxa-7-aza-1(3,6)-imidazo[1,2-b]pyridazina-2(4,6)-pyrimidina-5(1,2)-benzenacycloheptaphane::US20260028352, Example I-78	High affinity nerve growth factor receptor NTRK1 [F589L]			<5.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540326	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2119&target=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540326&enzyme=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search			121446979	464925312							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVLEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,8J5W,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238486	C[C@H]1Nc2ccc3ncc(n3n2)-c2cc(cnn2)COc2ncc(F)cc21	InChI=1S/C18H14FN7O/c1-10-13-5-12(19)7-21-18(13)27-9-11-4-14(24-22-6-11)15-8-20-17-3-2-16(23-10)25-26(15)17/h2-8,10H,9H2,1H3,(H,23,25)	ZLLHYJSRMXVLPA-UHFFFAOYSA-N	540327	(6R,E)-55-fluoro-6-methyl-4-oxa-7-aza-1(3,6)-imidazo[1,2-b]pyridazina-2(2,4)-pyrimidina-5(2,3)-pyridinacycloheptaphane::US20260028352, Example I-79	High affinity nerve growth factor receptor NTRK1 [F589L]			<5.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540327	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2119&target=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540327&enzyme=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search			121446978	464925313							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVLEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,8J5W,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238487	C[C@H]1Nc2ccc3ncc(n3n2)-c2nccc(n2)COc2ccc(F)cc21	InChI=1S/C19H15FN6O/c1-11-14-8-12(20)2-3-16(14)27-10-13-6-7-21-19(24-13)15-9-22-18-5-4-17(23-11)25-26(15)18/h2-9,11H,10H2,1H3,(H,23,25)	BYGBVECBYAMPII-UHFFFAOYSA-N	540328	(6R,E)-54-fluoro-6-methyl-4-oxa-7-aza-1(3,6)-imidazo[1,2-b]pyridazina-2(2,4)-pyrimidina-5(1,2)-benzenacycloheptaphane::US20260028352, Example I-80	High affinity nerve growth factor receptor NTRK1 [F589L]			<5.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540328	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2119&target=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540328&enzyme=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search			121447355	464925314							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVLEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,8J5W,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238488	C[C@H]1Nc2ccc3ncc(n3n2)-c2nccc(n2)COc2ncc(F)cc21	InChI=1S/C18H14FN7O/c1-10-13-6-11(19)7-22-18(13)27-9-12-4-5-20-17(24-12)14-8-21-16-3-2-15(23-10)25-26(14)16/h2-8,10H,9H2,1H3,(H,23,25)	OQQZEJIPQHVGQX-UHFFFAOYSA-N	540329	(6R,E)-55-fluoro-6-methyl-4-oxa-7-aza-1(3,6)-imidazo[1,2-b]pyridazina-2(3,5)-pyridazina-5(2,3)-pyridinacycloheptaphane::US20260028352, Example I-81	High affinity nerve growth factor receptor NTRK1 [F589L]			<5.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540329	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2119&target=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540329&enzyme=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search			121447461	464925315							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVLEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,8J5W,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238489	C[C@H]1Nc2ccc3ncc(n3n2)-c2cc(cnn2)COc2ccc(F)cc21	InChI=1S/C19H15FN6O/c1-11-14-7-13(20)2-3-17(14)27-10-12-6-15(24-22-8-12)16-9-21-19-5-4-18(23-11)25-26(16)19/h2-9,11H,10H2,1H3,(H,23,25)	IJVJPIMDCODZAB-UHFFFAOYSA-N	540330	(6R,E)-54-fluoro-6-methyl-4-oxa-7-aza-1(3,6)-imidazo[1,2-b]pyridazina-2(3,5)-pyridazina-5(1,2)-benzenacycloheptaphane::US20260028352, Example I-82	High affinity nerve growth factor receptor NTRK1 [F589L]			<5.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540330	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2119&target=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540330&enzyme=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search			121447458	464925316							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVLEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,8J5W,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238490	C[C@H]1Nc2ccc3ncc(n3n2)-c2nccc(n2)CCOc2ncc(F)cc21	InChI=1S/C19H16FN7O/c1-11-14-8-12(20)9-23-19(14)28-7-5-13-4-6-21-18(25-13)15-10-22-17-3-2-16(24-11)26-27(15)17/h2-4,6,8-11H,5,7H2,1H3,(H,24,26)	MNVXNXSGPBOSBR-UHFFFAOYSA-N	540331	(4R,E)-5'-fluoro-4-methyl-6-oxa-3-aza-2(3,6)-imidazo[1,2-b]pyridazina-1(2,4)-pyrimidina-5(3,2)-pyridinacyclooctaphane::US20260028352, Example I-83	High affinity nerve growth factor receptor NTRK1 [F589L]			<5.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540331	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2119&target=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540331&enzyme=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search			121447460	464925317							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVLEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,8J5W,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238491	C[C@H]1Nc2ccc3ncc(n3n2)-c2nccc(n2)CCOc2ccc(F)cc21	InChI=1S/C20H17FN6O/c1-12-15-10-13(21)2-3-17(15)28-9-7-14-6-8-22-20(25-14)16-11-23-19-5-4-18(24-12)26-27(16)19/h2-6,8,10-12H,7,9H2,1H3,(H,24,26)	PNDCHWPHEFOMOG-UHFFFAOYSA-N	540332	(4R,E)-55-fluoro-4-methyl-6-oxa-3-aza-2(3,6)-imidazo[1,2-b]pyridazina-1(2,4)-pyrimidina-5(1,2)-benzenacyclooctaphane::US20260028352, Example I-84	High affinity nerve growth factor receptor NTRK1 [F589L]			<5.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540332	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2119&target=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540332&enzyme=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search			121447208	464925318							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVLEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,8J5W,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238492	Fc1ccc2c(c1)[C@H]1CCCN1c1ccc3ncc(n3n1)-c1cc(cnn1)CCO2	InChI=1S/C22H19FN6O/c23-15-3-4-20-16(11-15)18-2-1-8-28(18)22-6-5-21-24-13-19(29(21)27-22)17-10-14(7-9-30-20)12-25-26-17/h3-6,10-13,18H,1-2,7-9H2	VIFOCYIRFRXQGF-UHFFFAOYSA-N	540333	(32R,E)-45-fluoro-5-oxa-2(3,6)-imidazo[1,2-b]pyridazina-1(2,4)-pyrimidina-3(1,2)-pyrrolidina-4(1,2)-benzenacycloheptaphane::US20260028352, Example I-85	High affinity nerve growth factor receptor NTRK1 [F589L]			<5.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540333	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2119&target=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540333&enzyme=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search			121446993	464925319							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVLEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,8J5W,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238493	Fc1ccc2c(c1)[C@H]1C[C@H](F)CN1c1ccc3ncc(n3n1)-c1cc(cnn1)CCO2	InChI=1S/C22H18F2N6O/c23-14-1-2-20-16(8-14)18-9-15(24)12-29(18)22-4-3-21-25-11-19(30(21)28-22)17-7-13(5-6-31-20)10-26-27-17/h1-4,7-8,10-11,15,18H,5-6,9,12H2	ZEZNDHCNBDOTRM-UHFFFAOYSA-N	540334	(32R,34S,E)-34,45-difluoro-5-oxa-2(3,6)-imidazo[1,2-b]pyridazina-1(2,4)-pyrimidina-3(1,2)-pyrrolidina-4(1,2)-benzenacycloheptaphane::US20260028352, Example I-86	High affinity nerve growth factor receptor NTRK1 [F589L]			<5.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540334	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2119&target=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540334&enzyme=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search			121447096	464925320							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVLEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,8J5W,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238494	Fc1cnc2c(c1)[C@H]1CCCN1c1ccc3ncc(n3n1)-c1cc(cnn1)CCO2	InChI=1S/C21H18FN7O/c22-14-9-15-17-2-1-6-28(17)20-4-3-19-23-12-18(29(19)27-20)16-8-13(10-25-26-16)5-7-30-21(15)24-11-14/h3-4,8-12,17H,1-2,5-7H2	QOLNLLQKCFGNAI-UHFFFAOYSA-N	540335	(32R,E)-45-fluoro-5-oxa-2(3,6)-imidazo[1,2-b]pyridazina-1(2,4)-pyrimidina-4(3,2)-pyridina-3(1,2)-pyrrolidinacycloheptaphane::US20260028352, Example I-87	High affinity nerve growth factor receptor NTRK1 [F589L]			<5.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540335	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2119&target=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540335&enzyme=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search			121447459	464925321							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVLEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,8J5W,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238495	Fc1cnc2c(c1)[C@H]1C[C@H](F)CN1c1ccc3ncc(n3n1)-c1cc(cnn1)CCO2	InChI=1S/C21H17F2N7O/c22-13-6-15-17-7-14(23)11-29(17)20-2-1-19-24-10-18(30(19)28-20)16-5-12(8-26-27-16)3-4-31-21(15)25-9-13/h1-2,5-6,8-10,14,17H,3-4,7,11H2	KRDMHZJTFZABTE-UHFFFAOYSA-N	540336	(32R,34S,E)-34,45-difluoro-5-oxa-2(3,6)-imidazo[1,2-b]pyridazina-1(2,4)-pyrimidina-4(3,2)-pyridina-3(1,2)-pyrrolidinacycloheptaphane::US20260028352, Example I-88	High affinity nerve growth factor receptor NTRK1 [F589L]			<5.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540336	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2119&target=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540336&enzyme=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search			121447362	464925322							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVLEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,8J5W,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238496	C[C@H]1Nc2ccc3ncc(n3n2)-c2cc(cnn2)CCOc2ncc(F)cc21	InChI=1S/C19H16FN7O/c1-11-14-7-13(20)9-22-19(14)28-5-4-12-6-15(25-23-8-12)16-10-21-18-3-2-17(24-11)26-27(16)18/h2-3,6-11H,4-5H2,1H3,(H,24,26)	URFRZVBRUIDOFM-UHFFFAOYSA-N	540337	(4R,E)-5-fluoro-4-methyl-6-oxa-3-aza-2(3,6)-imidazo[1,2-b]pyridazina-1(3,5)-pyridazina-5(3,2)-pyridinacyclooctaphane::US20260028352, Example I-89	High affinity nerve growth factor receptor NTRK1 [F589L]			<5.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540337	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2119&target=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540337&enzyme=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search			121447361	464925323							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVLEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,8J5W,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238497	Cc1ccc2c(c1)[C@H]1C[C@H](F)CN1c1ccc3ncc(n3n1)-c1cc(ncn1)C[C@@H](C)O2	InChI=1S/C24H23FN6O/c1-14-3-4-22-18(7-14)20-9-16(25)12-30(20)24-6-5-23-26-11-21(31(23)29-24)19-10-17(27-13-28-19)8-15(2)32-22/h3-7,10-11,13,15-16,20H,8-9,12H2,1-2H3	STKXNCGIJKZKPO-UHFFFAOYSA-N	540338	(32R,E)-45-fluoro-5-oxa-2(3,6)-imidazo[1,2-b]pyridazina-1(3,5)-pyridazina-3(1,2)-pyrrolidina-4(1,2)-benzenacycloheptaphane::US20260028352, Example I-91	High affinity nerve growth factor receptor NTRK1 [F589L]			<5.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540338	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2119&target=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540338&enzyme=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search			121447240	464925324							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVLEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,8J5W,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238498	Fc1ccc2c(c1)[C@H]1CCCN1c1ccc3ncc(n3n1)-c1nccc(n1)CCO2	InChI=1S/C22H19FN6O/c23-14-3-4-19-16(12-14)17-2-1-10-28(17)21-6-5-20-25-13-18(29(20)27-21)22-24-9-7-15(26-22)8-11-30-19/h3-7,9,12-13,17H,1-2,8,10-11H2	AJOLLQOIWWMNAL-UHFFFAOYSA-N	540339	(32R,34S,E)-34,45-difluoro-5-oxa-2(3,6)-imidazo[1,2-b]pyridazina-1(3,5)-pyridazina-3(1,2)-pyrrolidina-4(1,2)-benzenacycloheptaphane::US20260028352, Example I-92	High affinity nerve growth factor receptor NTRK1 [F589L]			<5.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540339	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2119&target=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540339&enzyme=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search			121447469	464925325							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVLEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,8J5W,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238499	Fc1ccc2c(c1)[C@H]1C[C@H](F)CN1c1ccc3ncc(n3n1)-c1nccc(n1)CCO2	InChI=1S/C22H18F2N6O/c23-13-1-2-19-16(9-13)17-10-14(24)12-29(17)21-4-3-20-26-11-18(30(20)28-21)22-25-7-5-15(27-22)6-8-31-19/h1-5,7,9,11,14,17H,6,8,10,12H2	WXTNRBNDUNEAMP-UHFFFAOYSA-N	540340	(32R,E)-45-fluoro-5-oxa-2(3,6)-imidazo[1,2-b]pyridazina-1(3,5)-pyridazina-4(3,2)-pyridina-3(1,2)-pyrrolidinacycloheptaphane::US20260028352, Example I-93	High affinity nerve growth factor receptor NTRK1 [F589L]			<5.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540340	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2119&target=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540340&enzyme=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search			121447097	464925326							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVLEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,8J5W,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238500	Fc1cnc2c(c1)[C@H]1CCCN1c1ccc3ncc(n3n1)-c1nccc(n1)CCO2	InChI=1S/C21H18FN7O/c22-13-10-15-16-2-1-8-28(16)19-4-3-18-24-12-17(29(18)27-19)20-23-7-5-14(26-20)6-9-30-21(15)25-11-13/h3-5,7,10-12,16H,1-2,6,8-9H2	OXNMAOWCSBZHCX-UHFFFAOYSA-N	540341	(32R,34S,E)-34,4-difluoro-5-oxa-2(3,6)-imidazo[1,2-b]pyridazina-1(3,5)-pyridazina-4(3,2)-pyridina-3(1,2)-pyrrolidinacycloheptaphane::US20260028352, Example I-94	High affinity nerve growth factor receptor NTRK1 [F589L]			<5.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540341	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2119&target=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540341&enzyme=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search			121447369	464925327							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVLEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,8J5W,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238501	C[C@H]1Cc2ccnc(n2)-c2cnc3ccc(nn23)N2CCC[C@@H]2c2cc(F)cnc2O1	InChI=1S/C22H20FN7O/c1-13-9-15-6-7-24-21(27-15)18-12-25-19-4-5-20(28-30(18)19)29-8-2-3-17(29)16-10-14(23)11-26-22(16)31-13/h4-7,10-13,17H,2-3,8-9H2,1H3	HISWMXAMZABLCC-UHFFFAOYSA-N	540342	(32R,6S,E)-4-fluoro-6-methyl-5-oxa-2(3,6)-imidazo[1,2-b]pyridazina-1(2,4)-pyrimidina-4(3,2)-pyridina-3(1,2)-pyrrolidinacycloheptaphane::US20260028352, Example I-95	High affinity nerve growth factor receptor NTRK1 [F589L]			<5.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540342	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2119&target=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540342&enzyme=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search			121447101	464925328							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVLEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,8J5W,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238502	C[C@H]1Cc2ccnc(n2)-c2cnc3ccc(nn23)N2C[C@@H](F)C[C@@H]2c2cc(F)cnc2O1	InChI=1S/C22H19F2N7O/c1-12-6-15-4-5-25-21(28-15)18-10-26-19-2-3-20(29-31(18)19)30-11-14(24)8-17(30)16-7-13(23)9-27-22(16)32-12/h2-5,7,9-10,12,14,17H,6,8,11H2,1H3	OZEFUYILFLZQOJ-UHFFFAOYSA-N	540343	(32R,34S,6S,E)-34,45-difluoro-6-methyl-5-oxa-2(3,6)-imidazo[1,2-b]pyridazina-1(2,4)-pyrimidina-4(3,2)-pyridina-3(1,2)-pyrrolidinacycloheptaphane::US20260028352, Example I-96	High affinity nerve growth factor receptor NTRK1 [F589L]			<5.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540343	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2119&target=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540343&enzyme=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search			121447244	464925329							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVLEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,8J5W,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238503	C[C@@H]1Cc2cc(ncn2)-c2cnc3ccc(nn23)N2CCC[C@@H]2c2cc(F)ccc2O1	InChI=1S/C23H21FN6O/c1-14-9-16-11-18(27-13-26-16)20-12-25-22-6-7-23(28-30(20)22)29-8-2-3-19(29)17-10-15(24)4-5-21(17)31-14/h4-7,10-14,19H,2-3,8-9H2,1H3	KJONIUKEHHAWPC-UHFFFAOYSA-N	540344	(32R,6R,E)-45-fluoro-6-methyl-5-oxa-2(3,6)-imidazo[1,2-b]pyridazina-1(4,6)-pyrimidina-3(1,2)-pyrrolidina-4(1,2)-benzenacycloheptaphane::US20260028352, Example I-97	High affinity nerve growth factor receptor NTRK1 [F589L]			<5.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540344	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2119&target=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540344&enzyme=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search			121447474	464925330							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVLEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,8J5W,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238504	Fc1cnc2c(c1)[C@H]1C[C@H](F)CN1c1ccc3ncc(n3n1)-c1nccc(n1)CCO2	InChI=1S/C21H17F2N7O/c22-12-7-15-16-8-13(23)11-29(16)19-2-1-18-25-10-17(30(18)28-19)20-24-5-3-14(27-20)4-6-31-21(15)26-9-12/h1-3,5,7,9-10,13,16H,4,6,8,11H2	WLVFPGQPYJJSMY-UHFFFAOYSA-N	540345	(32R,34S,6R,E)-34,45-difluoro-6-methyl-5-oxa-2(3,6)-imidazo[1,2-b]pyridazina-1(4,6)-pyrimidina-3(1,2)-pyrrolidina-4(1,2)-benzenacycloheptaphane::US20260028352, Example I-98	High affinity nerve growth factor receptor NTRK1 [F589L]			<5.00							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540345	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2119&target=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540345&enzyme=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search			121447107	464925331							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVLEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,8J5W,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238505	C[C@@H]1CCc2ncc(F)cc2[C@H]2CCCN2c2ccn3ncc(C(=O)N1)c3n2	InChI=1S/C20H21FN6O/c1-12-4-5-16-14(9-13(21)10-22-16)17-3-2-7-26(17)18-6-8-27-19(25-18)15(11-23-27)20(28)24-12/h6,8-12,17H,2-5,7H2,1H3,(H,24,28)	OEBIHOVSAMBXIB-UHFFFAOYSA-N	50507492	Loxo-195::Selitrectinib::US10966985, Compound 33-B::US12428433, Example LOXO-195::US20260028352, Example LOXO-195	High affinity nerve growth factor receptor NTRK1 [F589L]			 6.50							US Patent		10.7270/Q2TF0351		aid1800172	US20260028352	XING, L; ZHU, W; LIU, H; WU, F	1/29/2026	6/10/2026	Suzhou Langrui Biopharmaceutical	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50507492	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2119&target=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50507492&enzyme=High+affinity+nerve+growth+factor+receptor+NTRK1+%5BF589L%5D&column=ki&startPg=0&Increment=50&submit=Search			129103609	440716077							1	MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVLEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG	2IFG,5H3Q,4AOJ,8J5W,5WR7,1HE7,1WWA,8YTE,8YTD,1WWW	High affinity nerve growth factor receptor	NTRK1_HUMAN	P04629	B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7