BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Date of publication Date in BindingDB Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID PubChem SID ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence 1 PDB ID(s) of Target Chain 1 UniProt (SwissProt) Recommended Name of Target Chain 1 UniProt (SwissProt) Entry Name of Target Chain 1 UniProt (SwissProt) Primary ID of Target Chain 1 UniProt (SwissProt) Secondary ID(s) of Target Chain 1 UniProt (SwissProt) Alternative ID(s) of Target Chain 1 UniProt (TrEMBL) Submitted Name of Target Chain 1 UniProt (TrEMBL) Entry Name of Target Chain 1 UniProt (TrEMBL) Primary ID of Target Chain 1 UniProt (TrEMBL) Secondary ID(s) of Target Chain 1 UniProt (TrEMBL) Alternative ID(s) of Target Chain 1 BindingDB Target Chain Sequence 2 PDB ID(s) of Target Chain 2 UniProt (SwissProt) Recommended Name of Target Chain 2 UniProt (SwissProt) Entry Name of Target Chain 2 UniProt (SwissProt) Primary ID of Target Chain 2 UniProt (SwissProt) Secondary ID(s) of Target Chain 2 UniProt (SwissProt) Alternative ID(s) of Target Chain 2 UniProt (TrEMBL) Submitted Name of Target Chain 2 UniProt (TrEMBL) Entry Name of Target Chain 2 UniProt (TrEMBL) Primary ID of Target Chain 2 UniProt (TrEMBL) Secondary ID(s) of Target Chain 2 UniProt (TrEMBL) Alternative ID(s) of Target Chain 2 BindingDB Target Chain Sequence 3 PDB ID(s) of Target Chain 3 UniProt (SwissProt) Recommended Name of Target Chain 3 UniProt (SwissProt) Entry Name of Target Chain 3 UniProt (SwissProt) Primary ID of Target Chain 3 UniProt (SwissProt) Secondary ID(s) of Target Chain 3 UniProt (SwissProt) Alternative ID(s) of Target Chain 3 UniProt (TrEMBL) Submitted Name of Target Chain 3 UniProt (TrEMBL) Entry Name of Target Chain 3 UniProt (TrEMBL) Primary ID of Target Chain 3 UniProt (TrEMBL) Secondary ID(s) of Target Chain 3 UniProt (TrEMBL) Alternative ID(s) of Target Chain 3 BindingDB Target Chain Sequence 4 PDB ID(s) of Target Chain 4 UniProt (SwissProt) Recommended Name of Target Chain 4 UniProt (SwissProt) Entry Name of Target Chain 4 UniProt (SwissProt) Primary ID of Target Chain 4 UniProt (SwissProt) Secondary ID(s) of Target Chain 4 UniProt (SwissProt) Alternative ID(s) of Target Chain 4 UniProt (TrEMBL) Submitted Name of Target Chain 4 UniProt (TrEMBL) Entry Name of Target Chain 4 UniProt (TrEMBL) Primary ID of Target Chain 4 UniProt (TrEMBL) Secondary ID(s) of Target Chain 4 UniProt (TrEMBL) Alternative ID(s) of Target Chain 4 BindingDB Target Chain Sequence 5 PDB ID(s) of Target Chain 5 UniProt (SwissProt) Recommended Name of Target Chain 5 UniProt (SwissProt) Entry Name of Target Chain 5 UniProt (SwissProt) Primary ID of Target Chain 5 UniProt (SwissProt) Secondary ID(s) of Target Chain 5 UniProt (SwissProt) Alternative ID(s) of Target Chain 5 UniProt (TrEMBL) Submitted Name of Target Chain 5 UniProt (TrEMBL) Entry Name of Target Chain 5 UniProt (TrEMBL) Primary ID of Target Chain 5 UniProt (TrEMBL) Secondary ID(s) of Target Chain 5 UniProt (TrEMBL) Alternative ID(s) of Target Chain 5 BindingDB Target Chain Sequence 6 PDB ID(s) of Target Chain 6 UniProt (SwissProt) Recommended Name of Target Chain 6 UniProt (SwissProt) Entry Name of Target Chain 6 UniProt (SwissProt) Primary ID of Target Chain 6 UniProt (SwissProt) Secondary ID(s) of Target Chain 6 UniProt (SwissProt) Alternative ID(s) of Target Chain 6 UniProt (TrEMBL) Submitted Name of Target Chain 6 UniProt (TrEMBL) Entry Name of Target Chain 6 UniProt (TrEMBL) Primary ID of Target Chain 6 UniProt (TrEMBL) Secondary ID(s) of Target Chain 6 UniProt (TrEMBL) Alternative ID(s) of Target Chain 6 BindingDB Target Chain Sequence 7 PDB ID(s) of Target Chain 7 UniProt (SwissProt) Recommended Name of Target Chain 7 UniProt (SwissProt) Entry Name of Target Chain 7 UniProt (SwissProt) Primary ID of Target Chain 7 UniProt (SwissProt) Secondary ID(s) of Target Chain 7 UniProt (SwissProt) Alternative ID(s) of Target Chain 7 UniProt (TrEMBL) Submitted Name of Target Chain 7 UniProt (TrEMBL) Entry Name of Target Chain 7 UniProt (TrEMBL) Primary ID of Target Chain 7 UniProt (TrEMBL) Secondary ID(s) of Target Chain 7 UniProt (TrEMBL) Alternative ID(s) of Target Chain 7 BindingDB Target Chain Sequence 8 PDB ID(s) of Target Chain 8 UniProt (SwissProt) Recommended Name of Target Chain 8 UniProt (SwissProt) Entry Name of Target Chain 8 UniProt (SwissProt) Primary ID of Target Chain 8 UniProt (SwissProt) Secondary ID(s) of Target Chain 8 UniProt (SwissProt) Alternative ID(s) of Target Chain 8 UniProt (TrEMBL) Submitted Name of Target Chain 8 UniProt (TrEMBL) Entry Name of Target Chain 8 UniProt (TrEMBL) Primary ID of Target Chain 8 UniProt (TrEMBL) Secondary ID(s) of Target Chain 8 UniProt (TrEMBL) Alternative ID(s) of Target Chain 8 BindingDB Target Chain Sequence 9 PDB ID(s) of Target Chain 9 UniProt (SwissProt) Recommended Name of Target Chain 9 UniProt (SwissProt) Entry Name of Target Chain 9 UniProt (SwissProt) Primary ID of Target Chain 9 UniProt (SwissProt) Secondary ID(s) of Target Chain 9 UniProt (SwissProt) Alternative ID(s) of Target Chain 9 UniProt (TrEMBL) Submitted Name of Target Chain 9 UniProt (TrEMBL) Entry Name of Target Chain 9 UniProt (TrEMBL) Primary ID of Target Chain 9 UniProt (TrEMBL) Secondary ID(s) of Target Chain 9 UniProt (TrEMBL) Alternative ID(s) of Target Chain 9 BindingDB Target Chain Sequence 10 PDB ID(s) of Target Chain 10 UniProt (SwissProt) Recommended Name of Target Chain 10 UniProt (SwissProt) Entry Name of Target Chain 10 UniProt (SwissProt) Primary ID of Target Chain 10 UniProt (SwissProt) Secondary ID(s) of Target Chain 10 UniProt (SwissProt) Alternative ID(s) of Target Chain 10 UniProt (TrEMBL) Submitted Name of Target Chain 10 UniProt (TrEMBL) Entry Name of Target Chain 10 UniProt (TrEMBL) Primary ID of Target Chain 10 UniProt (TrEMBL) Secondary ID(s) of Target Chain 10 UniProt (TrEMBL) Alternative ID(s) of Target Chain 10 BindingDB Target Chain Sequence 11 PDB ID(s) of Target Chain 11 UniProt (SwissProt) Recommended Name of Target Chain 11 UniProt (SwissProt) Entry Name of Target Chain 11 UniProt (SwissProt) Primary ID of Target Chain 11 UniProt (SwissProt) Secondary ID(s) of Target Chain 11 UniProt (SwissProt) Alternative ID(s) of Target Chain 11 UniProt (TrEMBL) Submitted Name of Target Chain 11 UniProt (TrEMBL) Entry Name of Target Chain 11 UniProt (TrEMBL) Primary ID of Target Chain 11 UniProt (TrEMBL) Secondary ID(s) of Target Chain 11 UniProt (TrEMBL) Alternative ID(s) of Target Chain 11 BindingDB Target Chain Sequence 12 PDB ID(s) of Target Chain 12 UniProt (SwissProt) Recommended Name of Target Chain 12 UniProt (SwissProt) Entry Name of Target Chain 12 UniProt (SwissProt) Primary ID of Target Chain 12 UniProt (SwissProt) Secondary ID(s) of Target Chain 12 UniProt (SwissProt) Alternative ID(s) of Target Chain 12 UniProt (TrEMBL) Submitted Name of Target Chain 12 UniProt (TrEMBL) Entry Name of Target Chain 12 UniProt (TrEMBL) Primary ID of Target Chain 12 UniProt (TrEMBL) Secondary ID(s) of Target Chain 12 UniProt (TrEMBL) Alternative ID(s) of Target Chain 12 BindingDB Target Chain Sequence 13 PDB ID(s) of Target Chain 13 UniProt (SwissProt) Recommended Name of Target Chain 13 UniProt (SwissProt) Entry Name of Target Chain 13 UniProt (SwissProt) Primary ID of Target Chain 13 UniProt (SwissProt) Secondary ID(s) of Target Chain 13 UniProt (SwissProt) Alternative ID(s) of Target Chain 13 UniProt (TrEMBL) Submitted Name of Target Chain 13 UniProt (TrEMBL) Entry Name of Target Chain 13 UniProt (TrEMBL) Primary ID of Target Chain 13 UniProt (TrEMBL) Secondary ID(s) of Target Chain 13 UniProt (TrEMBL) Alternative ID(s) of Target Chain 13 BindingDB Target Chain Sequence 14 PDB ID(s) of Target Chain 14 UniProt (SwissProt) Recommended Name of Target Chain 14 UniProt (SwissProt) Entry Name of Target Chain 14 UniProt (SwissProt) Primary ID of Target Chain 14 UniProt (SwissProt) Secondary ID(s) of Target Chain 14 UniProt (SwissProt) Alternative ID(s) of Target Chain 14 UniProt (TrEMBL) Submitted Name of Target Chain 14 UniProt (TrEMBL) Entry Name of Target Chain 14 UniProt (TrEMBL) Primary ID of Target Chain 14 UniProt (TrEMBL) Secondary ID(s) of Target Chain 14 UniProt (TrEMBL) Alternative ID(s) of Target Chain 14 BindingDB Target Chain Sequence 15 PDB ID(s) of Target Chain 15 UniProt (SwissProt) Recommended Name of Target Chain 15 UniProt (SwissProt) Entry Name of Target Chain 15 UniProt (SwissProt) Primary ID of Target Chain 15 UniProt (SwissProt) Secondary ID(s) of Target Chain 15 UniProt (SwissProt) Alternative ID(s) of Target Chain 15 UniProt (TrEMBL) Submitted Name of Target Chain 15 UniProt (TrEMBL) Entry Name of Target Chain 15 UniProt (TrEMBL) Primary ID of Target Chain 15 UniProt (TrEMBL) Secondary ID(s) of Target Chain 15 UniProt (TrEMBL) Alternative ID(s) of Target Chain 15 BindingDB Target Chain Sequence 16 PDB ID(s) of Target Chain 16 UniProt (SwissProt) Recommended Name of Target Chain 16 UniProt (SwissProt) Entry Name of Target Chain 16 UniProt (SwissProt) Primary ID of Target Chain 16 UniProt (SwissProt) Secondary ID(s) of Target Chain 16 UniProt (SwissProt) Alternative ID(s) of Target Chain 16 UniProt (TrEMBL) Submitted Name of Target Chain 16 UniProt (TrEMBL) Entry Name of Target Chain 16 UniProt (TrEMBL) Primary ID of Target Chain 16 UniProt (TrEMBL) Secondary ID(s) of Target Chain 16 UniProt (TrEMBL) Alternative ID(s) of Target Chain 16 BindingDB Target Chain Sequence 17 PDB ID(s) of Target Chain 17 UniProt (SwissProt) Recommended Name of Target Chain 17 UniProt (SwissProt) Entry Name of Target Chain 17 UniProt (SwissProt) Primary ID of Target Chain 17 UniProt (SwissProt) Secondary ID(s) of Target Chain 17 UniProt (SwissProt) Alternative ID(s) of Target Chain 17 UniProt (TrEMBL) Submitted Name of Target Chain 17 UniProt (TrEMBL) Entry Name of Target Chain 17 UniProt (TrEMBL) Primary ID of Target Chain 17 UniProt (TrEMBL) Secondary ID(s) of Target Chain 17 UniProt (TrEMBL) Alternative ID(s) of Target Chain 17 BindingDB Target Chain Sequence 18 PDB ID(s) of Target Chain 18 UniProt (SwissProt) Recommended Name of Target Chain 18 UniProt (SwissProt) Entry Name of Target Chain 18 UniProt (SwissProt) Primary ID of Target Chain 18 UniProt (SwissProt) Secondary ID(s) of Target Chain 18 UniProt (SwissProt) Alternative ID(s) of Target Chain 18 UniProt (TrEMBL) Submitted Name of Target Chain 18 UniProt (TrEMBL) Entry Name of Target Chain 18 UniProt (TrEMBL) Primary ID of Target Chain 18 UniProt (TrEMBL) Secondary ID(s) of Target Chain 18 UniProt (TrEMBL) Alternative ID(s) of Target Chain 18 BindingDB Target Chain Sequence 19 PDB ID(s) of Target Chain 19 UniProt (SwissProt) Recommended Name of Target Chain 19 UniProt (SwissProt) Entry Name of Target Chain 19 UniProt (SwissProt) Primary ID of Target Chain 19 UniProt (SwissProt) Secondary ID(s) of Target Chain 19 UniProt (SwissProt) Alternative ID(s) of Target Chain 19 UniProt (TrEMBL) Submitted Name of Target Chain 19 UniProt (TrEMBL) Entry Name of Target Chain 19 UniProt (TrEMBL) Primary ID of Target Chain 19 UniProt (TrEMBL) Secondary ID(s) of Target Chain 19 UniProt (TrEMBL) Alternative ID(s) of Target Chain 19 BindingDB Target Chain Sequence 20 PDB ID(s) of Target Chain 20 UniProt (SwissProt) Recommended Name of Target Chain 20 UniProt (SwissProt) Entry Name of Target Chain 20 UniProt (SwissProt) Primary ID of Target Chain 20 UniProt (SwissProt) Secondary ID(s) of Target Chain 20 UniProt (SwissProt) Alternative ID(s) of Target Chain 20 UniProt (TrEMBL) Submitted Name of Target Chain 20 UniProt (TrEMBL) Entry Name of Target Chain 20 UniProt (TrEMBL) Primary ID of Target Chain 20 UniProt (TrEMBL) Secondary ID(s) of Target Chain 20 UniProt (TrEMBL) Alternative ID(s) of Target Chain 20 BindingDB Target Chain Sequence 21 PDB ID(s) of Target Chain 21 UniProt (SwissProt) Recommended Name of Target Chain 21 UniProt (SwissProt) Entry Name of Target Chain 21 UniProt (SwissProt) Primary ID of Target Chain 21 UniProt (SwissProt) Secondary ID(s) of Target Chain 21 UniProt (SwissProt) Alternative ID(s) of Target Chain 21 UniProt (TrEMBL) Submitted Name of Target Chain 21 UniProt (TrEMBL) Entry Name of Target Chain 21 UniProt (TrEMBL) Primary ID of Target Chain 21 UniProt (TrEMBL) Secondary ID(s) of Target Chain 21 UniProt (TrEMBL) Alternative ID(s) of Target Chain 21 BindingDB Target Chain Sequence 22 PDB ID(s) of Target Chain 22 UniProt (SwissProt) Recommended Name of Target Chain 22 UniProt (SwissProt) Entry Name of Target Chain 22 UniProt (SwissProt) Primary ID of Target Chain 22 UniProt (SwissProt) Secondary ID(s) of Target Chain 22 UniProt (SwissProt) Alternative ID(s) of Target Chain 22 UniProt (TrEMBL) Submitted Name of Target Chain 22 UniProt (TrEMBL) Entry Name of Target Chain 22 UniProt (TrEMBL) Primary ID of Target Chain 22 UniProt (TrEMBL) Secondary ID(s) of Target Chain 22 UniProt (TrEMBL) Alternative ID(s) of Target Chain 22 BindingDB Target Chain Sequence 23 PDB ID(s) of Target Chain 23 UniProt (SwissProt) Recommended Name of Target Chain 23 UniProt (SwissProt) Entry Name of Target Chain 23 UniProt (SwissProt) Primary ID of Target Chain 23 UniProt (SwissProt) Secondary ID(s) of Target Chain 23 UniProt (SwissProt) Alternative ID(s) of Target Chain 23 UniProt (TrEMBL) Submitted Name of Target Chain 23 UniProt (TrEMBL) Entry Name of Target Chain 23 UniProt (TrEMBL) Primary ID of Target Chain 23 UniProt (TrEMBL) Secondary ID(s) of Target Chain 23 UniProt (TrEMBL) Alternative ID(s) of Target Chain 23 BindingDB Target Chain Sequence 24 PDB ID(s) of Target Chain 24 UniProt (SwissProt) Recommended Name of Target Chain 24 UniProt (SwissProt) Entry Name of Target Chain 24 UniProt (SwissProt) Primary ID of Target Chain 24 UniProt (SwissProt) Secondary ID(s) of Target Chain 24 UniProt (SwissProt) Alternative ID(s) of Target Chain 24 UniProt (TrEMBL) Submitted Name of Target Chain 24 UniProt (TrEMBL) Entry Name of Target Chain 24 UniProt (TrEMBL) Primary ID of Target Chain 24 UniProt (TrEMBL) Secondary ID(s) of Target Chain 24 UniProt (TrEMBL) Alternative ID(s) of Target Chain 24 BindingDB Target Chain Sequence 25 PDB ID(s) of Target Chain 25 UniProt (SwissProt) Recommended Name of Target Chain 25 UniProt (SwissProt) Entry Name of Target Chain 25 UniProt (SwissProt) Primary ID of Target Chain 25 UniProt (SwissProt) Secondary ID(s) of Target Chain 25 UniProt (SwissProt) Alternative ID(s) of Target Chain 25 UniProt (TrEMBL) Submitted Name of Target Chain 25 UniProt (TrEMBL) Entry Name of Target Chain 25 UniProt (TrEMBL) Primary ID of Target Chain 25 UniProt (TrEMBL) Secondary ID(s) of Target Chain 25 UniProt (TrEMBL) Alternative ID(s) of Target Chain 25 BindingDB Target Chain Sequence 26 PDB ID(s) of Target Chain 26 UniProt (SwissProt) Recommended Name of Target Chain 26 UniProt (SwissProt) Entry Name of Target Chain 26 UniProt (SwissProt) Primary ID of Target Chain 26 UniProt (SwissProt) Secondary ID(s) of Target Chain 26 UniProt (SwissProt) Alternative ID(s) of Target Chain 26 UniProt (TrEMBL) Submitted Name of Target Chain 26 UniProt (TrEMBL) Entry Name of Target Chain 26 UniProt (TrEMBL) Primary ID of Target Chain 26 UniProt (TrEMBL) Secondary ID(s) of Target Chain 26 UniProt (TrEMBL) Alternative ID(s) of Target Chain 26 BindingDB Target Chain Sequence 27 PDB ID(s) of Target Chain 27 UniProt (SwissProt) Recommended Name of Target Chain 27 UniProt (SwissProt) Entry Name of Target Chain 27 UniProt (SwissProt) Primary ID of Target Chain 27 UniProt (SwissProt) Secondary ID(s) of Target Chain 27 UniProt (SwissProt) Alternative ID(s) of Target Chain 27 UniProt (TrEMBL) Submitted Name of Target Chain 27 UniProt (TrEMBL) Entry Name of Target Chain 27 UniProt (TrEMBL) Primary ID of Target Chain 27 UniProt (TrEMBL) Secondary ID(s) of Target Chain 27 UniProt (TrEMBL) Alternative ID(s) of Target Chain 27 BindingDB Target Chain Sequence 28 PDB ID(s) of Target Chain 28 UniProt (SwissProt) Recommended Name of Target Chain 28 UniProt (SwissProt) Entry Name of Target Chain 28 UniProt (SwissProt) Primary ID of Target Chain 28 UniProt (SwissProt) Secondary ID(s) of Target Chain 28 UniProt (SwissProt) Alternative ID(s) of Target Chain 28 UniProt (TrEMBL) Submitted Name of Target Chain 28 UniProt (TrEMBL) Entry Name of Target Chain 28 UniProt (TrEMBL) Primary ID of Target Chain 28 UniProt (TrEMBL) Secondary ID(s) of Target Chain 28 UniProt (TrEMBL) Alternative ID(s) of Target Chain 28 BindingDB Target Chain Sequence 29 PDB ID(s) of Target Chain 29 UniProt (SwissProt) Recommended Name of Target Chain 29 UniProt (SwissProt) Entry Name of Target Chain 29 UniProt (SwissProt) Primary ID of Target Chain 29 UniProt (SwissProt) Secondary ID(s) of Target Chain 29 UniProt (SwissProt) Alternative ID(s) of Target Chain 29 UniProt (TrEMBL) Submitted Name of Target Chain 29 UniProt (TrEMBL) Entry Name of Target Chain 29 UniProt (TrEMBL) Primary ID of Target Chain 29 UniProt (TrEMBL) Secondary ID(s) of Target Chain 29 UniProt (TrEMBL) Alternative ID(s) of Target Chain 29 BindingDB Target Chain Sequence 30 PDB ID(s) of Target Chain 30 UniProt (SwissProt) Recommended Name of Target Chain 30 UniProt (SwissProt) Entry Name of Target Chain 30 UniProt (SwissProt) Primary ID of Target Chain 30 UniProt (SwissProt) Secondary ID(s) of Target Chain 30 UniProt (SwissProt) Alternative ID(s) of Target Chain 30 UniProt (TrEMBL) Submitted Name of Target Chain 30 UniProt (TrEMBL) Entry Name of Target Chain 30 UniProt (TrEMBL) Primary ID of Target Chain 30 UniProt (TrEMBL) Secondary ID(s) of Target Chain 30 UniProt (TrEMBL) Alternative ID(s) of Target Chain 30 BindingDB Target Chain Sequence 31 PDB ID(s) of Target Chain 31 UniProt (SwissProt) Recommended Name of Target Chain 31 UniProt (SwissProt) Entry Name of Target Chain 31 UniProt (SwissProt) Primary ID of Target Chain 31 UniProt (SwissProt) Secondary ID(s) of Target Chain 31 UniProt (SwissProt) Alternative ID(s) of Target Chain 31 UniProt (TrEMBL) Submitted Name of Target Chain 31 UniProt (TrEMBL) Entry Name of Target Chain 31 UniProt (TrEMBL) Primary ID of Target Chain 31 UniProt (TrEMBL) Secondary ID(s) of Target Chain 31 UniProt (TrEMBL) Alternative ID(s) of Target Chain 31 BindingDB Target Chain Sequence 32 PDB ID(s) of Target Chain 32 UniProt (SwissProt) Recommended Name of Target Chain 32 UniProt (SwissProt) Entry Name of Target Chain 32 UniProt (SwissProt) Primary ID of Target Chain 32 UniProt (SwissProt) Secondary ID(s) of Target Chain 32 UniProt (SwissProt) Alternative ID(s) of Target Chain 32 UniProt (TrEMBL) Submitted Name of Target Chain 32 UniProt (TrEMBL) Entry Name of Target Chain 32 UniProt (TrEMBL) Primary ID of Target Chain 32 UniProt (TrEMBL) Secondary ID(s) of Target Chain 32 UniProt (TrEMBL) Alternative ID(s) of Target Chain 32 BindingDB Target Chain Sequence 33 PDB ID(s) of Target Chain 33 UniProt (SwissProt) Recommended Name of Target Chain 33 UniProt (SwissProt) Entry Name of Target Chain 33 UniProt (SwissProt) Primary ID of Target Chain 33 UniProt (SwissProt) Secondary ID(s) of Target Chain 33 UniProt (SwissProt) Alternative ID(s) of Target Chain 33 UniProt (TrEMBL) Submitted Name of Target Chain 33 UniProt (TrEMBL) Entry Name of Target Chain 33 UniProt (TrEMBL) Primary ID of Target Chain 33 UniProt (TrEMBL) Secondary ID(s) of Target Chain 33 UniProt (TrEMBL) Alternative ID(s) of Target Chain 33 BindingDB Target Chain Sequence 34 PDB ID(s) of Target Chain 34 UniProt (SwissProt) Recommended Name of Target Chain 34 UniProt (SwissProt) Entry Name of Target Chain 34 UniProt (SwissProt) Primary ID of Target Chain 34 UniProt (SwissProt) Secondary ID(s) of Target Chain 34 UniProt (SwissProt) Alternative ID(s) of Target Chain 34 UniProt (TrEMBL) Submitted Name of Target Chain 34 UniProt (TrEMBL) Entry Name of Target Chain 34 UniProt (TrEMBL) Primary ID of Target Chain 34 UniProt (TrEMBL) Secondary ID(s) of Target Chain 34 UniProt (TrEMBL) Alternative ID(s) of Target Chain 34 BindingDB Target Chain Sequence 35 PDB ID(s) of Target Chain 35 UniProt (SwissProt) Recommended Name of Target Chain 35 UniProt (SwissProt) Entry Name of Target Chain 35 UniProt (SwissProt) Primary ID of Target Chain 35 UniProt (SwissProt) Secondary ID(s) of Target Chain 35 UniProt (SwissProt) Alternative ID(s) of Target Chain 35 UniProt (TrEMBL) Submitted Name of Target Chain 35 UniProt (TrEMBL) Entry Name of Target Chain 35 UniProt (TrEMBL) Primary ID of Target Chain 35 UniProt (TrEMBL) Secondary ID(s) of Target Chain 35 UniProt (TrEMBL) Alternative ID(s) of Target Chain 35 BindingDB Target Chain Sequence 36 PDB ID(s) of Target Chain 36 UniProt (SwissProt) Recommended Name of Target Chain 36 UniProt (SwissProt) Entry Name of Target Chain 36 UniProt (SwissProt) Primary ID of Target Chain 36 UniProt (SwissProt) Secondary ID(s) of Target Chain 36 UniProt (SwissProt) Alternative ID(s) of Target Chain 36 UniProt (TrEMBL) Submitted Name of Target Chain 36 UniProt (TrEMBL) Entry Name of Target Chain 36 UniProt (TrEMBL) Primary ID of Target Chain 36 UniProt (TrEMBL) Secondary ID(s) of Target Chain 36 UniProt (TrEMBL) Alternative ID(s) of Target Chain 36 BindingDB Target Chain Sequence 37 PDB ID(s) of Target Chain 37 UniProt (SwissProt) Recommended Name of Target Chain 37 UniProt (SwissProt) Entry Name of Target Chain 37 UniProt (SwissProt) Primary ID of Target Chain 37 UniProt (SwissProt) Secondary ID(s) of Target Chain 37 UniProt (SwissProt) Alternative ID(s) of Target Chain 37 UniProt (TrEMBL) Submitted Name of Target Chain 37 UniProt (TrEMBL) Entry Name of Target Chain 37 UniProt (TrEMBL) Primary ID of Target Chain 37 UniProt (TrEMBL) Secondary ID(s) of Target Chain 37 UniProt (TrEMBL) Alternative ID(s) of Target Chain 37 BindingDB Target Chain Sequence 38 PDB ID(s) of Target Chain 38 UniProt (SwissProt) Recommended Name of Target Chain 38 UniProt (SwissProt) Entry Name of Target Chain 38 UniProt (SwissProt) Primary ID of Target Chain 38 UniProt (SwissProt) Secondary ID(s) of Target Chain 38 UniProt (SwissProt) Alternative ID(s) of Target Chain 38 UniProt (TrEMBL) Submitted Name of Target Chain 38 UniProt (TrEMBL) Entry Name of Target Chain 38 UniProt (TrEMBL) Primary ID of Target Chain 38 UniProt (TrEMBL) Secondary ID(s) of Target Chain 38 UniProt (TrEMBL) Alternative ID(s) of Target Chain 38 BindingDB Target Chain Sequence 39 PDB ID(s) of Target Chain 39 UniProt (SwissProt) Recommended Name of Target Chain 39 UniProt (SwissProt) Entry Name of Target Chain 39 UniProt (SwissProt) Primary ID of Target Chain 39 UniProt (SwissProt) Secondary ID(s) of Target Chain 39 UniProt (SwissProt) Alternative ID(s) of Target Chain 39 UniProt (TrEMBL) Submitted Name of Target Chain 39 UniProt (TrEMBL) Entry Name of Target Chain 39 UniProt (TrEMBL) Primary ID of Target Chain 39 UniProt (TrEMBL) Secondary ID(s) of Target Chain 39 UniProt (TrEMBL) Alternative ID(s) of Target Chain 39 BindingDB Target Chain Sequence 40 PDB ID(s) of Target Chain 40 UniProt (SwissProt) Recommended Name of Target Chain 40 UniProt (SwissProt) Entry Name of Target Chain 40 UniProt (SwissProt) Primary ID of Target Chain 40 UniProt (SwissProt) Secondary ID(s) of Target Chain 40 UniProt (SwissProt) Alternative ID(s) of Target Chain 40 UniProt (TrEMBL) Submitted Name of Target Chain 40 UniProt (TrEMBL) Entry Name of Target Chain 40 UniProt (TrEMBL) Primary ID of Target Chain 40 UniProt (TrEMBL) Secondary ID(s) of Target Chain 40 UniProt (TrEMBL) Alternative ID(s) of Target Chain 40 BindingDB Target Chain Sequence 41 PDB ID(s) of Target Chain 41 UniProt (SwissProt) Recommended Name of Target Chain 41 UniProt (SwissProt) Entry Name of Target Chain 41 UniProt (SwissProt) Primary ID of Target Chain 41 UniProt (SwissProt) Secondary ID(s) of Target Chain 41 UniProt (SwissProt) Alternative ID(s) of Target Chain 41 UniProt (TrEMBL) Submitted Name of Target Chain 41 UniProt (TrEMBL) Entry Name of Target Chain 41 UniProt (TrEMBL) Primary ID of Target Chain 41 UniProt (TrEMBL) Secondary ID(s) of Target Chain 41 UniProt (TrEMBL) Alternative ID(s) of Target Chain 41 BindingDB Target Chain Sequence 42 PDB ID(s) of Target Chain 42 UniProt (SwissProt) Recommended Name of Target Chain 42 UniProt (SwissProt) Entry Name of Target Chain 42 UniProt (SwissProt) Primary ID of Target Chain 42 UniProt (SwissProt) Secondary ID(s) of Target Chain 42 UniProt (SwissProt) Alternative ID(s) of Target Chain 42 UniProt (TrEMBL) Submitted Name of Target Chain 42 UniProt (TrEMBL) Entry Name of Target Chain 42 UniProt (TrEMBL) Primary ID of Target Chain 42 UniProt (TrEMBL) Secondary ID(s) of Target Chain 42 UniProt (TrEMBL) Alternative ID(s) of Target Chain 42 BindingDB Target Chain Sequence 43 PDB ID(s) of Target Chain 43 UniProt (SwissProt) Recommended Name of Target Chain 43 UniProt (SwissProt) Entry Name of Target Chain 43 UniProt (SwissProt) Primary ID of Target Chain 43 UniProt (SwissProt) Secondary ID(s) of Target Chain 43 UniProt (SwissProt) Alternative ID(s) of Target Chain 43 UniProt (TrEMBL) Submitted Name of Target Chain 43 UniProt (TrEMBL) Entry Name of Target Chain 43 UniProt (TrEMBL) Primary ID of Target Chain 43 UniProt (TrEMBL) Secondary ID(s) of Target Chain 43 UniProt (TrEMBL) Alternative ID(s) of Target Chain 43 BindingDB Target Chain Sequence 44 PDB ID(s) of Target Chain 44 UniProt (SwissProt) Recommended Name of Target Chain 44 UniProt (SwissProt) Entry Name of Target Chain 44 UniProt (SwissProt) Primary ID of Target Chain 44 UniProt (SwissProt) Secondary ID(s) of Target Chain 44 UniProt (SwissProt) Alternative ID(s) of Target Chain 44 UniProt (TrEMBL) Submitted Name of Target Chain 44 UniProt (TrEMBL) Entry Name of Target Chain 44 UniProt (TrEMBL) Primary ID of Target Chain 44 UniProt (TrEMBL) Secondary ID(s) of Target Chain 44 UniProt (TrEMBL) Alternative ID(s) of Target Chain 44 BindingDB Target Chain Sequence 45 PDB ID(s) of Target Chain 45 UniProt (SwissProt) Recommended Name of Target Chain 45 UniProt (SwissProt) Entry Name of Target Chain 45 UniProt (SwissProt) Primary ID of Target Chain 45 UniProt (SwissProt) Secondary ID(s) of Target Chain 45 UniProt (SwissProt) Alternative ID(s) of Target Chain 45 UniProt (TrEMBL) Submitted Name of Target Chain 45 UniProt (TrEMBL) Entry Name of Target Chain 45 UniProt (TrEMBL) Primary ID of Target Chain 45 UniProt (TrEMBL) Secondary ID(s) of Target Chain 45 UniProt (TrEMBL) Alternative ID(s) of Target Chain 45 BindingDB Target Chain Sequence 46 PDB ID(s) of Target Chain 46 UniProt (SwissProt) Recommended Name of Target Chain 46 UniProt (SwissProt) Entry Name of Target Chain 46 UniProt (SwissProt) Primary ID of Target Chain 46 UniProt (SwissProt) Secondary ID(s) of Target Chain 46 UniProt (SwissProt) Alternative ID(s) of Target Chain 46 UniProt (TrEMBL) Submitted Name of Target Chain 46 UniProt (TrEMBL) Entry Name of Target Chain 46 UniProt (TrEMBL) Primary ID of Target Chain 46 UniProt (TrEMBL) Secondary ID(s) of Target Chain 46 UniProt (TrEMBL) Alternative ID(s) of Target Chain 46 BindingDB Target Chain Sequence 47 PDB ID(s) of Target Chain 47 UniProt (SwissProt) Recommended Name of Target Chain 47 UniProt (SwissProt) Entry Name of Target Chain 47 UniProt (SwissProt) Primary ID of Target Chain 47 UniProt (SwissProt) Secondary ID(s) of Target Chain 47 UniProt (SwissProt) Alternative ID(s) of Target Chain 47 UniProt (TrEMBL) Submitted Name of Target Chain 47 UniProt (TrEMBL) Entry Name of Target Chain 47 UniProt (TrEMBL) Primary ID of Target Chain 47 UniProt (TrEMBL) Secondary ID(s) of Target Chain 47 UniProt (TrEMBL) Alternative ID(s) of Target Chain 47 BindingDB Target Chain Sequence 48 PDB ID(s) of Target Chain 48 UniProt (SwissProt) Recommended Name of Target Chain 48 UniProt (SwissProt) Entry Name of Target Chain 48 UniProt (SwissProt) Primary ID of Target Chain 48 UniProt (SwissProt) Secondary ID(s) of Target Chain 48 UniProt (SwissProt) Alternative ID(s) of Target Chain 48 UniProt (TrEMBL) Submitted Name of Target Chain 48 UniProt (TrEMBL) Entry Name of Target Chain 48 UniProt (TrEMBL) Primary ID of Target Chain 48 UniProt (TrEMBL) Secondary ID(s) of Target Chain 48 UniProt (TrEMBL) Alternative ID(s) of Target Chain 48 BindingDB Target Chain Sequence 49 PDB ID(s) of Target Chain 49 UniProt (SwissProt) Recommended Name of Target Chain 49 UniProt (SwissProt) Entry Name of Target Chain 49 UniProt (SwissProt) Primary ID of Target Chain 49 UniProt (SwissProt) Secondary ID(s) of Target Chain 49 UniProt (SwissProt) Alternative ID(s) of Target Chain 49 UniProt (TrEMBL) Submitted Name of Target Chain 49 UniProt (TrEMBL) Entry Name of Target Chain 49 UniProt (TrEMBL) Primary ID of Target Chain 49 UniProt (TrEMBL) Secondary ID(s) of Target Chain 49 UniProt (TrEMBL) Alternative ID(s) of Target Chain 49 BindingDB Target Chain Sequence 50 PDB ID(s) of Target Chain 50 UniProt (SwissProt) Recommended Name of Target Chain 50 UniProt (SwissProt) Entry Name of Target Chain 50 UniProt (SwissProt) Primary ID of Target Chain 50 UniProt (SwissProt) Secondary ID(s) of Target Chain 50 UniProt (SwissProt) Alternative ID(s) of Target Chain 50 UniProt (TrEMBL) Submitted Name of Target Chain 50 UniProt (TrEMBL) Entry Name of Target Chain 50 UniProt (TrEMBL) Primary ID of Target Chain 50 UniProt (TrEMBL) Secondary ID(s) of Target Chain 50 UniProt (TrEMBL) Alternative ID(s) of Target Chain 50 396090 Fc1ccc(nc1)-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)NCc2cnn[nH]2)c(Cl)cc1Cl InChI=1S/C25H17Cl2FN8O2/c26-19-9-20(27)18(8-17(19)21-7-6-14(28)11-29-21)24(37)32-23-10-22(25(38)30-12-15-13-31-35-33-15)34-36(23)16-4-2-1-3-5-16/h1-11,13H,12H2,(H,30,38)(H,32,37)(H,31,33,35) KALIFTRTIKALOT-UHFFFAOYSA-N 226308 US9328096, 1 High affinity nerve growth factor receptor [441-796] Human 7.3 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226308 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226308&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118497150 336293456 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396091 OCCNC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccc(F)cn2)n(n1)-c1ccccc1 InChI=1S/C24H18Cl2FN5O3/c25-18-11-19(26)17(10-16(18)20-7-6-14(27)13-29-20)23(34)30-22-12-21(24(35)28-8-9-33)31-32(22)15-4-2-1-3-5-15/h1-7,10-13,33H,8-9H2,(H,28,35)(H,30,34) GURGHMWZVNKDRF-UHFFFAOYSA-N 226309 US9328096, 2 High affinity nerve growth factor receptor [441-796] Human 25.9 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226309 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226309&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118497102 336293457 C04080 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396092 Cc1n[nH]cc1NC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C26H19ClFN7O2/c1-15-22(14-30-33-15)31-26(37)21-13-23(35(34-21)17-6-3-2-4-7-17)32-25(36)18-12-16(9-10-19(18)27)24-20(28)8-5-11-29-24/h2-14H,1H3,(H,30,33)(H,31,37)(H,32,36) CFHYOADDEKEKQD-UHFFFAOYSA-N 226310 US9328096, 3 High affinity nerve growth factor receptor [441-796] Human 11.14 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226310 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226310&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118497066 336293458 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396093 Fc1cccnc1-c1ccc(Cl)c(c1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCc1c[nH]nn1 InChI=1S/C25H18ClFN8O2/c26-19-9-8-15(23-20(27)7-4-10-28-23)11-18(19)24(36)31-22-12-21(25(37)29-13-16-14-30-34-32-16)33-35(22)17-5-2-1-3-6-17/h1-12,14H,13H2,(H,29,37)(H,31,36)(H,30,32,34) IRLNXTWGTRVAJZ-UHFFFAOYSA-N 226311 US9328096, 4 High affinity nerve growth factor receptor [441-796] Human 16.87 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226311 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226311&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118497118 336293459 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396094 C[C@H](O)CNC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C25H20ClF2N5O3/c1-14(34)13-30-25(36)21-12-22(33(32-21)15-6-3-2-4-7-15)31-24(35)16-10-17(20(28)11-18(16)26)23-19(27)8-5-9-29-23/h2-12,14,34H,13H2,1H3,(H,30,36)(H,31,35)/t14-/m0/s1 XWBPKJRHDXVFDJ-AWEZNQCLSA-N 226312 US9328096, 5 High affinity nerve growth factor receptor [441-796] Human 17.76 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226312 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226312&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118497067 336293460 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396095 Fc1cccnc1-c1ccc(Cl)c(c1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCc1ncc[nH]1 InChI=1S/C26H19ClFN7O2/c27-19-9-8-16(24-20(28)7-4-10-31-24)13-18(19)25(36)33-23-14-21(26(37)32-15-22-29-11-12-30-22)34-35(23)17-5-2-1-3-6-17/h1-14H,15H2,(H,29,30)(H,32,37)(H,33,36) ROLXITLMLYYQAU-UHFFFAOYSA-N 226314 US9328096, 7 High affinity nerve growth factor receptor [441-796] Human 147.62 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226314 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226314&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118506964 336293461 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396096 Fc1cccnc1-c1ccc(Cl)c(c1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCc1cc[nH]n1 InChI=1S/C26H19ClFN7O2/c27-20-9-8-16(24-21(28)7-4-11-29-24)13-19(20)25(36)32-23-14-22(26(37)30-15-17-10-12-31-33-17)34-35(23)18-5-2-1-3-6-18/h1-14H,15H2,(H,30,37)(H,31,33)(H,32,36) SGFJNYFVFBRJQR-UHFFFAOYSA-N 226315 US9328096, 8 High affinity nerve growth factor receptor [441-796] Human 31.96 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226315 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226315&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118508010 336293462 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396097 Nc1cc(CNC(=O)c2cc(NC(=O)c3cc(ccc3Cl)-c3ncccc3F)n(n2)-c2ccccc2)n[nH]1 InChI=1S/C26H20ClFN8O2/c27-19-9-8-15(24-20(28)7-4-10-30-24)11-18(19)25(37)32-23-13-21(35-36(23)17-5-2-1-3-6-17)26(38)31-14-16-12-22(29)34-33-16/h1-13H,14H2,(H,31,38)(H,32,37)(H3,29,33,34) RDLSXSPDTXILGJ-UHFFFAOYSA-N 226316 US9328096, 9 High affinity nerve growth factor receptor [441-796] Human 65.84 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226316 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226316&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118506995 336293463 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396098 OCC(O)CNC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C25H21ClFN5O4/c26-19-9-8-15(23-20(27)7-4-10-28-23)11-18(19)24(35)30-22-12-21(25(36)29-13-17(34)14-33)31-32(22)16-5-2-1-3-6-16/h1-12,17,33-34H,13-14H2,(H,29,36)(H,30,35) MFLSXBLWCLOAKP-UHFFFAOYSA-N 226317 US9328096, 10 High affinity nerve growth factor receptor [441-796] Human 115.63 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226317 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226317&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118506994 336293464 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396099 Fc1cccnc1-c1ccc(Cl)c(c1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCc1cn[nH]c1 InChI=1S/C26H19ClFN7O2/c27-20-9-8-17(24-21(28)7-4-10-29-24)11-19(20)25(36)33-23-12-22(26(37)30-13-16-14-31-32-15-16)34-35(23)18-5-2-1-3-6-18/h1-12,14-15H,13H2,(H,30,37)(H,31,32)(H,33,36) WCPVQEMIGWGFON-UHFFFAOYSA-N 226318 US9328096, 11 High affinity nerve growth factor receptor [441-796] Human 8.74 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226318 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226318&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118497127 336293465 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396100 C[C@@H](O)CNC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C25H21ClFN5O3/c1-15(33)14-29-25(35)21-13-22(32(31-21)17-6-3-2-4-7-17)30-24(34)18-12-16(9-10-19(18)26)23-20(27)8-5-11-28-23/h2-13,15,33H,14H2,1H3,(H,29,35)(H,30,34)/t15-/m1/s1 JHLYNQYZBILXJV-OAHLLOKOSA-N 226319 US9328096, 12 High affinity nerve growth factor receptor [441-796] Human 84.18 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226319 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226319&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118506997 336293466 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396101 Fc1cccnc1-c1ccc(Cl)c(c1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCc1nnc[nH]1 InChI=1S/C25H18ClFN8O2/c26-18-9-8-15(23-19(27)7-4-10-28-23)11-17(18)24(36)32-22-12-20(25(37)29-13-21-30-14-31-33-21)34-35(22)16-5-2-1-3-6-16/h1-12,14H,13H2,(H,29,37)(H,32,36)(H,30,31,33) KQYOYPXAIAXTLT-UHFFFAOYSA-N 226320 US9328096, 13 High affinity nerve growth factor receptor [441-796] Human 80.64 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226320 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226320&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118506996 336293467 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396102 Cc1nnc(CNC(=O)c2cc(NC(=O)c3cc(ccc3Cl)-c3ncccc3F)n(n2)-c2ccccc2)[nH]1 InChI=1S/C26H20ClFN8O2/c1-15-31-22(34-33-15)14-30-26(38)21-13-23(36(35-21)17-6-3-2-4-7-17)32-25(37)18-12-16(9-10-19(18)27)24-20(28)8-5-11-29-24/h2-13H,14H2,1H3,(H,30,38)(H,32,37)(H,31,33,34) UFJVZLXUQTVNJY-UHFFFAOYSA-N 226321 US9328096, 14 High affinity nerve growth factor receptor [441-796] Human 71.23 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226321 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226321&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118507001 336293468 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396103 CC(C)(CO)NC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C26H23ClFN5O3/c1-26(2,15-34)31-25(36)21-14-22(33(32-21)17-7-4-3-5-8-17)30-24(35)18-13-16(10-11-19(18)27)23-20(28)9-6-12-29-23/h3-14,34H,15H2,1-2H3,(H,30,35)(H,31,36) HHFFEXGHKOXHHW-UHFFFAOYSA-N 226322 US9328096, 15 High affinity nerve growth factor receptor [441-796] Human 63.95 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226322 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226322&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118508000 336293469 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396104 Cc1c[nH]nc1NC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C26H19ClFN7O2/c1-15-14-30-33-24(15)32-26(37)21-13-22(35(34-21)17-6-3-2-4-7-17)31-25(36)18-12-16(9-10-19(18)27)23-20(28)8-5-11-29-23/h2-14H,1H3,(H,31,36)(H2,30,32,33,37) PVUBDDNISHYVAZ-UHFFFAOYSA-N 226323 US9328096, 16 High affinity nerve growth factor receptor [441-796] Human 222.43 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226323 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226323&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118507000 336293470 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396105 C[C@H](O)CNC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C25H21ClFN5O3/c1-15(33)14-29-25(35)21-13-22(32(31-21)17-6-3-2-4-7-17)30-24(34)18-12-16(9-10-19(18)26)23-20(27)8-5-11-28-23/h2-13,15,33H,14H2,1H3,(H,29,35)(H,30,34)/t15-/m0/s1 JHLYNQYZBILXJV-HNNXBMFYSA-N 226324 US9328096, 17 High affinity nerve growth factor receptor [441-796] Human 61.7 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226324 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226324&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118506999 336293471 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396106 Fc1cccnc1-c1ccc(Cl)c(c1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCc1ccncn1 InChI=1S/C27H19ClFN7O2/c28-21-9-8-17(25-22(29)7-4-11-31-25)13-20(21)26(37)34-24-14-23(35-36(24)19-5-2-1-3-6-19)27(38)32-15-18-10-12-30-16-33-18/h1-14,16H,15H2,(H,32,38)(H,34,37) KXXGFQBAKREODE-UHFFFAOYSA-N 226325 US9328096, 18 High affinity nerve growth factor receptor [441-796] Human 62.17 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226325 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226325&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118506998 336293472 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396107 Fc1cccnc1-c1ccc(Cl)c(c1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCc1cnccn1 InChI=1S/C27H19ClFN7O2/c28-21-9-8-17(25-22(29)7-4-10-32-25)13-20(21)26(37)34-24-14-23(35-36(24)19-5-2-1-3-6-19)27(38)33-16-18-15-30-11-12-31-18/h1-15H,16H2,(H,33,38)(H,34,37) INYLDTSKLURYQD-UHFFFAOYSA-N 226326 US9328096, 19 High affinity nerve growth factor receptor [441-796] Human 45.65 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226326 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226326&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118506652 336293473 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396108 Fc1cccnc1-c1ccc(Cl)c(c1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCc1ncccn1 InChI=1S/C27H19ClFN7O2/c28-20-10-9-17(25-21(29)8-4-11-32-25)14-19(20)26(37)34-24-15-22(35-36(24)18-6-2-1-3-7-18)27(38)33-16-23-30-12-5-13-31-23/h1-15H,16H2,(H,33,38)(H,34,37) ADCBZXXKJCUTAR-UHFFFAOYSA-N 226327 US9328096, 20 High affinity nerve growth factor receptor [441-796] Human 180.03 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226327 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226327&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118506654 336293474 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396109 Cn1nncc1CNC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C26H20ClFN8O2/c1-35-18(15-31-34-35)14-30-26(38)22-13-23(36(33-22)17-6-3-2-4-7-17)32-25(37)19-12-16(9-10-20(19)27)24-21(28)8-5-11-29-24/h2-13,15H,14H2,1H3,(H,30,38)(H,32,37) SWQJOLGXQVIKLX-UHFFFAOYSA-N 226328 US9328096, 21 High affinity nerve growth factor receptor [441-796] Human 62.45 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226328 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226328&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118506650 336293475 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396110 Cn1cc(CNC(=O)c2cc(NC(=O)c3cc(ccc3Cl)-c3ncccc3F)n(n2)-c2ccccc2)nn1 InChI=1S/C26H20ClFN8O2/c1-35-15-17(32-34-35)14-30-26(38)22-13-23(36(33-22)18-6-3-2-4-7-18)31-25(37)19-12-16(9-10-20(19)27)24-21(28)8-5-11-29-24/h2-13,15H,14H2,1H3,(H,30,38)(H,31,37) ANTLZGYSUPEXAT-UHFFFAOYSA-N 226329 US9328096, 22 High affinity nerve growth factor receptor [441-796] Human 50.31 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226329 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226329&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118506653 336293476 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396111 Fc1cccnc1-c1ccc(Cl)c(c1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCc1cncnc1 InChI=1S/C27H19ClFN7O2/c28-21-9-8-18(25-22(29)7-4-10-32-25)11-20(21)26(37)34-24-12-23(35-36(24)19-5-2-1-3-6-19)27(38)33-15-17-13-30-16-31-14-17/h1-14,16H,15H2,(H,33,38)(H,34,37) KTZDEZGQLOAYBD-UHFFFAOYSA-N 226330 US9328096, 23 High affinity nerve growth factor receptor [441-796] Human 25.75 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226330 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226330&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118506655 336293477 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396112 Fc1cccnc1-c1ccc(Cl)c(c1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCc1cccnn1 InChI=1S/C27H19ClFN7O2/c28-21-11-10-17(25-22(29)9-5-12-30-25)14-20(21)26(37)33-24-15-23(35-36(24)19-7-2-1-3-8-19)27(38)31-16-18-6-4-13-32-34-18/h1-15H,16H2,(H,31,38)(H,33,37) FUEUSMHDKARLEJ-UHFFFAOYSA-N 226331 US9328096, 24 High affinity nerve growth factor receptor [441-796] Human 50.71 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226331 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226331&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118506647 336293478 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396113 Fc1cccnc1-c1ccc(Cl)c(c1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)Nc1cn[nH]c1 InChI=1S/C25H17ClFN7O2/c26-19-9-8-15(23-20(27)7-4-10-28-23)11-18(19)24(35)32-22-12-21(25(36)31-16-13-29-30-14-16)33-34(22)17-5-2-1-3-6-17/h1-14H,(H,29,30)(H,31,36)(H,32,35) XIVASRGPYLEGRM-UHFFFAOYSA-N 226332 US9328096, 25 High affinity nerve growth factor receptor [441-796] Human 43.92 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226332 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226332&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118506651 336293479 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396114 Clc1ccc(cc1C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCc1c[nH]nn1)-c1ncccc1Cl InChI=1S/C25H18Cl2N8O2/c26-19-9-8-15(23-20(27)7-4-10-28-23)11-18(19)24(36)31-22-12-21(25(37)29-13-16-14-30-34-32-16)33-35(22)17-5-2-1-3-6-17/h1-12,14H,13H2,(H,29,37)(H,31,36)(H,30,32,34) PWYCRPWCQRSQJO-UHFFFAOYSA-N 226333 US9328096, 26 High affinity nerve growth factor receptor [441-796] Human 23.14 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226333 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226333&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118506648 336293480 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396115 CC(NC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1)c1c[nH]nn1 226334 US9328096, 27 High affinity nerve growth factor receptor [441-796] Human 24.03 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226334 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226334&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118506649 336293481 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396116 Clc1cc(Cl)c(cc1C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCc1c[nH]nn1)-c1ccccn1 InChI=1S/C25H18Cl2N8O2/c26-19-11-20(27)18(10-17(19)21-8-4-5-9-28-21)24(36)31-23-12-22(25(37)29-13-15-14-30-34-32-15)33-35(23)16-6-2-1-3-7-16/h1-12,14H,13H2,(H,29,37)(H,31,36)(H,30,32,34) IYIZITQYIGTMBL-UHFFFAOYSA-N 226335 US9328096, 28 High affinity nerve growth factor receptor [441-796] Human 4.88 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226335 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226335&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118497148 336293482 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396117 Fc1cc(Cl)c(cc1-c1ccccn1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCc1c[nH]nn1 InChI=1S/C25H18ClFN8O2/c26-19-11-20(27)18(21-8-4-5-9-28-21)10-17(19)24(36)31-23-12-22(25(37)29-13-15-14-30-34-32-15)33-35(23)16-6-2-1-3-7-16/h1-12,14H,13H2,(H,29,37)(H,31,36)(H,30,32,34) NXUJXBBGGFTXKX-UHFFFAOYSA-N 226336 US9328096, 29 High affinity nerve growth factor receptor [441-796] Human 8.09 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226336 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226336&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118497098 336293483 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396118 Cc1n[nH]cc1NC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C26H19ClFN7O2/c1-15-23(14-30-33-15)31-26(37)22-13-24(35(34-22)16-7-3-2-4-8-16)32-25(36)17-11-18(20(28)12-19(17)27)21-9-5-6-10-29-21/h2-14H,1H3,(H,30,33)(H,31,37)(H,32,36) UITKZENQWFUCTA-UHFFFAOYSA-N 226337 US9328096, 30 High affinity nerve growth factor receptor [441-796] Human 7.268 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226337 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226337&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118497133 336293484 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396119 Fc1ccc(nc1)-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)NCc2c[nH]nn2)c(Cl)cc1F InChI=1S/C25H17ClF2N8O2/c26-19-9-20(28)18(21-7-6-14(27)11-29-21)8-17(19)24(37)32-23-10-22(25(38)30-12-15-13-31-35-33-15)34-36(23)16-4-2-1-3-5-16/h1-11,13H,12H2,(H,30,38)(H,32,37)(H,31,33,35) PGLNLJGOMCQXAQ-UHFFFAOYSA-N 226338 US9328096, 31 High affinity nerve growth factor receptor [441-796] Human 18.95 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226338 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226338&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118506935 336293485 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396120 C[C@@H](CO)NC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C25H21ClFN5O3/c1-15(14-33)29-25(35)21-13-22(32(31-21)17-6-3-2-4-7-17)30-24(34)18-12-16(9-10-19(18)26)23-20(27)8-5-11-28-23/h2-13,15,33H,14H2,1H3,(H,29,35)(H,30,34)/t15-/m0/s1 QMSYTNJGTPUNJN-HNNXBMFYSA-N 226339 US9328096, 32 High affinity nerve growth factor receptor [441-796] Human 118.2 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226339 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226339&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118506932 336293486 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396121 C[C@H](CO)NC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C25H21ClFN5O3/c1-15(14-33)29-25(35)21-13-22(32(31-21)17-6-3-2-4-7-17)30-24(34)18-12-16(9-10-19(18)26)23-20(27)8-5-11-28-23/h2-13,15,33H,14H2,1H3,(H,29,35)(H,30,34)/t15-/m1/s1 QMSYTNJGTPUNJN-OAHLLOKOSA-N 226340 US9328096, 33 High affinity nerve growth factor receptor [441-796] Human 132.2 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226340 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226340&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118508195 336293487 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396122 C[C@@H](CO)NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C25H21Cl2N5O3/c1-15(14-33)29-25(35)22-13-23(32(31-22)16-7-3-2-4-8-16)30-24(34)18-11-17(19(26)12-20(18)27)21-9-5-6-10-28-21/h2-13,15,33H,14H2,1H3,(H,29,35)(H,30,34)/t15-/m0/s1 IQHHAPKSJWCKBQ-HNNXBMFYSA-N 226341 US9328096, 34 High affinity nerve growth factor receptor [441-796] Human 10.72 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226341 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226341&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118497107 336293488 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396123 C[C@H](O)CNC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C25H21Cl2N5O3/c1-15(33)14-29-25(35)22-13-23(32(31-22)16-7-3-2-4-8-16)30-24(34)18-11-17(19(26)12-20(18)27)21-9-5-6-10-28-21/h2-13,15,33H,14H2,1H3,(H,29,35)(H,30,34)/t15-/m0/s1 IQOVSIHUPNSPGA-HNNXBMFYSA-N 226342 US9328096, 35 High affinity nerve growth factor receptor [441-796] Human 10.69 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226342 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226342&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118497176 336293489 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396124 Clc1cc(Cl)c(cc1C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCc1ccnnc1)-c1ccccn1 InChI=1S/C27H19Cl2N7O2/c28-21-13-22(29)20(12-19(21)23-8-4-5-10-30-23)26(37)34-25-14-24(35-36(25)18-6-2-1-3-7-18)27(38)31-15-17-9-11-32-33-16-17/h1-14,16H,15H2,(H,31,38)(H,34,37) XKSCHHZFNMISAD-UHFFFAOYSA-N 226343 US9328096, 36 High affinity nerve growth factor receptor [441-796] Human 7.24 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226343 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226343&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118497172 336293490 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396125 Cc1n[nH]c(C)c1NC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C27H21ClFN7O2/c1-15-24(16(2)34-33-15)32-27(38)22-14-23(36(35-22)18-7-4-3-5-8-18)31-26(37)19-13-17(10-11-20(19)28)25-21(29)9-6-12-30-25/h3-14H,1-2H3,(H,31,37)(H,32,38)(H,33,34) NHMUNSCAVXRBBJ-UHFFFAOYSA-N 226344 US9328096, 37 High affinity nerve growth factor receptor [441-796] Human 25.25 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226344 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226344&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118505201 336293491 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396126 CC1(CNC(=O)c2cc(NC(=O)c3cc(ccc3Cl)-c3ncccc3F)n(n2)-c2ccccc2)COC1 InChI=1S/C27H23ClFN5O3/c1-27(15-37-16-27)14-31-26(36)22-13-23(34(33-22)18-6-3-2-4-7-18)32-25(35)19-12-17(9-10-20(19)28)24-21(29)8-5-11-30-24/h2-13H,14-16H2,1H3,(H,31,36)(H,32,35) WPJSJGQVVLQLJG-UHFFFAOYSA-N 226345 US9328096, 38 High affinity nerve growth factor receptor [441-796] Human 114.7 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226345 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226345&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118505202 336293492 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396127 Fc1cc(Cl)c(cc1-c1ncccc1F)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCc1cn[nH]c1 InChI=1S/C26H18ClF2N7O2/c27-19-10-21(29)18(24-20(28)7-4-8-30-24)9-17(19)25(37)34-23-11-22(26(38)31-12-15-13-32-33-14-15)35-36(23)16-5-2-1-3-6-16/h1-11,13-14H,12H2,(H,31,38)(H,32,33)(H,34,37) QIYIEMTXZQYTET-UHFFFAOYSA-N 226346 US9328096, 39 High affinity nerve growth factor receptor [441-796] Human 1.936 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226346 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226346&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118497168 336293493 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396128 Cc1n[nH]cc1NC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C26H18ClF2N7O2/c1-14-22(13-31-34-14)32-26(38)21-12-23(36(35-21)15-6-3-2-4-7-15)33-25(37)16-10-17(20(29)11-18(16)27)24-19(28)8-5-9-30-24/h2-13H,1H3,(H,31,34)(H,32,38)(H,33,37) XWRMGEPHSBUZFF-UHFFFAOYSA-N 226347 US9328096, 40 High affinity nerve growth factor receptor [441-796] Human 3.174 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226347 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226347&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118497130 336293494 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396129 CC(C)(O)CNC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C26H22ClF2N5O3/c1-26(2,37)14-31-25(36)21-13-22(34(33-21)15-7-4-3-5-8-15)32-24(35)16-11-17(20(29)12-18(16)27)23-19(28)9-6-10-30-23/h3-13,37H,14H2,1-2H3,(H,31,36)(H,32,35) DWGOUKNTRRLHEG-UHFFFAOYSA-N 226348 US9328096, 41 High affinity nerve growth factor receptor [441-796] Human 23.92 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226348 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226348&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118507002 336293495 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396130 Clc1cc(Cl)c(cc1C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCc1ccn[nH]1)-c1ccccn1 InChI=1S/C26H19Cl2N7O2/c27-20-13-21(28)19(12-18(20)22-8-4-5-10-29-22)25(36)32-24-14-23(26(37)30-15-16-9-11-31-33-16)34-35(24)17-6-2-1-3-7-17/h1-14H,15H2,(H,30,37)(H,31,33)(H,32,36) PHGOTFJNVQEXME-UHFFFAOYSA-N 226349 US9328096, 42 High affinity nerve growth factor receptor [441-796] Human 5.117 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226349 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226349&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118497185 336293496 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396131 OCCNC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C24H18Cl2FN5O3/c25-17-12-18(26)16(11-15(17)22-19(27)7-4-8-28-22)23(34)30-21-13-20(24(35)29-9-10-33)31-32(21)14-5-2-1-3-6-14/h1-8,11-13,33H,9-10H2,(H,29,35)(H,30,34) WEPTZPALJYIKGT-UHFFFAOYSA-N 226350 US9328096, 43 High affinity nerve growth factor receptor [441-796] Human 5.187 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226350 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226350&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118497157 336293497 C04080 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396132 CNC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C23H17ClFN5O2/c1-26-23(32)19-13-20(30(29-19)15-6-3-2-4-7-15)28-22(31)16-12-14(9-10-17(16)24)21-18(25)8-5-11-27-21/h2-13H,1H3,(H,26,32)(H,28,31) KYGZKMOSMNJZRQ-UHFFFAOYSA-N 226351 US9328096, 44 High affinity nerve growth factor receptor [441-796] Human 47.96 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226351 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226351&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118506855 336293498 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396133 Cc1n[nH]cc1NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C26H19Cl2N7O2/c1-15-23(14-30-33-15)31-26(37)22-13-24(35(34-22)16-7-3-2-4-8-16)32-25(36)18-11-17(19(27)12-20(18)28)21-9-5-6-10-29-21/h2-14H,1H3,(H,30,33)(H,31,37)(H,32,36) PCUPEALJJVYHEF-UHFFFAOYSA-N 226352 US9328096, 45 High affinity nerve growth factor receptor [441-796] Human 3.925 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226352 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226352&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118497074 336293499 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396134 Clc1cc(Cl)c(cc1C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCc1cn[nH]c1)-c1ccccn1 InChI=1S/C26H19Cl2N7O2/c27-20-11-21(28)19(10-18(20)22-8-4-5-9-29-22)25(36)33-24-12-23(26(37)30-13-16-14-31-32-15-16)34-35(24)17-6-2-1-3-7-17/h1-12,14-15H,13H2,(H,30,37)(H,31,32)(H,33,36) NDWVAZDFWLZPMW-UHFFFAOYSA-N 226353 US9328096, 46 High affinity nerve growth factor receptor [441-796] Human 1.806 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226353 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226353&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118497139 336293500 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396135 CC(C)(O)CNC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C26H23Cl2N5O3/c1-26(2,36)15-30-25(35)22-14-23(33(32-22)16-8-4-3-5-9-16)31-24(34)18-12-17(19(27)13-20(18)28)21-10-6-7-11-29-21/h3-14,36H,15H2,1-2H3,(H,30,35)(H,31,34) NXDRKVFQQJUBOG-UHFFFAOYSA-N 226354 US9328096, 47 High affinity nerve growth factor receptor [441-796] Human 12.36 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226354 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226354&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search FQG 6D20 118497137 336293501 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396136 Fc1cccnc1-c1ccc(Cl)c(c1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCCc1c[nH]nn1 InChI=1S/C26H20ClFN8O2/c27-20-9-8-16(24-21(28)7-4-11-29-24)13-19(20)25(37)32-23-14-22(34-36(23)18-5-2-1-3-6-18)26(38)30-12-10-17-15-31-35-33-17/h1-9,11,13-15H,10,12H2,(H,30,38)(H,32,37)(H,31,33,35) NJGSOIZRAUSYIZ-UHFFFAOYSA-N 226355 US9328096, 48 High affinity nerve growth factor receptor [441-796] Human 68.63 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226355 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226355&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118508253 336293502 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396137 NCCNC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C24H20ClFN6O2/c25-18-9-8-15(22-19(26)7-4-11-28-22)13-17(18)23(33)30-21-14-20(24(34)29-12-10-27)31-32(21)16-5-2-1-3-6-16/h1-9,11,13-14H,10,12,27H2,(H,29,34)(H,30,33) DNGMVDUORRUDEH-UHFFFAOYSA-N 226356 US9328096, 49 High affinity nerve growth factor receptor [441-796] Human 142.2 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226356 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226356&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118497081 336293503 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396138 Fc1cccnc1-c1ccc(Cl)c(c1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NC1CNCC1(F)F InChI=1S/C26H20ClF3N6O2/c27-18-9-8-15(23-19(28)7-4-10-32-23)11-17(18)24(37)34-22-12-20(35-36(22)16-5-2-1-3-6-16)25(38)33-21-13-31-14-26(21,29)30/h1-12,21,31H,13-14H2,(H,33,38)(H,34,37) ZLPFUNXMUKXBTD-UHFFFAOYSA-N 226357 US9328096, 50 High affinity nerve growth factor receptor [441-796] Human 112.5 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226357 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226357&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118497105 336293504 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396139 NCCNC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C24H20Cl2N6O2/c25-18-13-19(26)17(12-16(18)20-8-4-5-10-28-20)23(33)30-22-14-21(24(34)29-11-9-27)31-32(22)15-6-2-1-3-7-15/h1-8,10,12-14H,9,11,27H2,(H,29,34)(H,30,33) OCIDSJUTXLBBDL-UHFFFAOYSA-N 226358 US9328096, 51 High affinity nerve growth factor receptor [441-796] Human 31.92 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226358 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226358&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118497050 336293505 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396140 Fc1cccnc1-c1ccc(Cl)c(c1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NC[C@H]1CNCCO1 InChI=1S/C27H24ClFN6O3/c28-21-9-8-17(25-22(29)7-4-10-31-25)13-20(21)26(36)33-24-14-23(34-35(24)18-5-2-1-3-6-18)27(37)32-16-19-15-30-11-12-38-19/h1-10,13-14,19,30H,11-12,15-16H2,(H,32,37)(H,33,36)/t19-/m1/s1 YSMYGZHNCFHWKY-LJQANCHMSA-N 226359 US9328096, 52 High affinity nerve growth factor receptor [441-796] Human 294.4 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226359 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226359&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118497187 336293506 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396141 Fc1cccnc1-c1ccc(Cl)c(c1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NC[C@@H]1CNCCO1 InChI=1S/C27H24ClFN6O3/c28-21-9-8-17(25-22(29)7-4-10-31-25)13-20(21)26(36)33-24-14-23(34-35(24)18-5-2-1-3-6-18)27(37)32-16-19-15-30-11-12-38-19/h1-10,13-14,19,30H,11-12,15-16H2,(H,32,37)(H,33,36)/t19-/m0/s1 YSMYGZHNCFHWKY-IBGZPJMESA-N 226360 US9328096, 53 High affinity nerve growth factor receptor [441-796] Human 272.7 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226360 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226360&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118497009 336293507 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396142 OCCNC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C24H19ClFN5O3/c25-18-9-8-15(22-19(26)7-4-10-27-22)13-17(18)23(33)29-21-14-20(24(34)28-11-12-32)30-31(21)16-5-2-1-3-6-16/h1-10,13-14,32H,11-12H2,(H,28,34)(H,29,33) CRRVAFLCSZOCID-UHFFFAOYSA-N 226361 US9328096, 54 High affinity nerve growth factor receptor [441-796] Human 67.39 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226361 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226361&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118497101 336293508 C04080 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396143 NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C22H15Cl2N5O2/c23-16-11-17(24)15(10-14(16)18-8-4-5-9-26-18)22(31)27-20-12-19(21(25)30)28-29(20)13-6-2-1-3-7-13/h1-12H,(H2,25,30)(H,27,31) QYGWCQIPDHCLRV-UHFFFAOYSA-N 226362 US9328096, 55 High affinity nerve growth factor receptor [441-796] Human 12.91 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226362 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226362&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118497153 336293509 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396144 NC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2cccc(n2)C(F)F)n(n1)-c1ccccc1 InChI=1S/C23H16ClF2N5O2/c24-16-10-9-13(17-7-4-8-18(28-17)21(25)26)11-15(16)23(33)29-20-12-19(22(27)32)30-31(20)14-5-2-1-3-6-14/h1-12,21H,(H2,27,32)(H,29,33) PCXRKXAIMDBGES-UHFFFAOYSA-N 226363 US9328096, 56 High affinity nerve growth factor receptor [441-796] Human 1065.83 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226363 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226363&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118505207 336293510 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396145 CC(F)(F)c1cccc(n1)-c1ccc(Cl)c(c1)C(=O)Nc1cc(nn1-c1ccccc1)C(N)=O InChI=1S/C24H18ClF2N5O2/c1-24(26,27)20-9-5-8-18(29-20)14-10-11-17(25)16(12-14)23(34)30-21-13-19(22(28)33)31-32(21)15-6-3-2-4-7-15/h2-13H,1H3,(H2,28,33)(H,30,34) ZVTZVLGSYBXATB-UHFFFAOYSA-N 226364 US9328096, 57 High affinity nerve growth factor receptor [441-796] Human 9239.97 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226364 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226364&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118505209 336293511 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396146 NC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2cccc(CC(F)F)n2)n(n1)-c1ccccc1 InChI=1S/C24H18ClF2N5O2/c25-18-10-9-14(19-8-4-5-15(29-19)12-21(26)27)11-17(18)24(34)30-22-13-20(23(28)33)31-32(22)16-6-2-1-3-7-16/h1-11,13,21H,12H2,(H2,28,33)(H,30,34) FEXWVJCHYHKQCY-UHFFFAOYSA-N 226365 US9328096, 58 High affinity nerve growth factor receptor [441-796] Human 598.89 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226365 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226365&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118505208 336293512 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396147 OCCNC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C24H19Cl2N5O3/c25-18-13-19(26)17(12-16(18)20-8-4-5-9-27-20)23(33)29-22-14-21(24(34)28-10-11-32)30-31(22)15-6-2-1-3-7-15/h1-9,12-14,32H,10-11H2,(H,28,34)(H,29,33) VIKITGKRDZGGGR-UHFFFAOYSA-N 226366 US9328096, 59 High affinity nerve growth factor receptor [441-796] Human 14.63 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226366 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226366&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118497126 336293513 C04080 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396148 COCc1cccc(n1)-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)NCCO)c(Cl)cc1Cl InChI=1S/C26H23Cl2N5O4/c1-37-15-16-6-5-9-22(30-16)18-12-19(21(28)13-20(18)27)25(35)31-24-14-23(26(36)29-10-11-34)32-33(24)17-7-3-2-4-8-17/h2-9,12-14,34H,10-11,15H2,1H3,(H,29,36)(H,31,35) NEHWOCKTOGJJIK-UHFFFAOYSA-N 226367 US9328096, 60 High affinity nerve growth factor receptor [441-796] Human 7.195 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226367 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226367&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118497103 336293514 C04080 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396149 OCCCNC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C25H21Cl2N5O3/c26-19-14-20(27)18(13-17(19)21-9-4-5-10-28-21)24(34)30-23-15-22(25(35)29-11-6-12-33)31-32(23)16-7-2-1-3-8-16/h1-5,7-10,13-15,33H,6,11-12H2,(H,29,35)(H,30,34) CKSVSZHBACAEOX-UHFFFAOYSA-N 226368 US9328096, 61 High affinity nerve growth factor receptor [441-796] Human 10.46 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226368 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226368&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118497159 336293515 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396150 COc1cccc(n1)-c1ccc(Cl)c(c1)C(=O)Nc1cc(nn1-c1ccccc1)C(N)=O InChI=1S/C23H18ClN5O3/c1-32-21-9-5-8-18(26-21)14-10-11-17(24)16(12-14)23(31)27-20-13-19(22(25)30)28-29(20)15-6-3-2-4-7-15/h2-13H,1H3,(H2,25,30)(H,27,31) WIOIZVPBAVBFAH-UHFFFAOYSA-N 226369 US9328096, 62 High affinity nerve growth factor receptor [441-796] Human 5250 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226369 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226369&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118505212 336293516 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396151 NC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2nc(CC#N)ccc2Cl)n(n1)-c1ccccc1 InChI=1S/C24H16Cl2N6O2/c25-18-8-6-14(22-19(26)9-7-15(29-22)10-11-27)12-17(18)24(34)30-21-13-20(23(28)33)31-32(21)16-4-2-1-3-5-16/h1-9,12-13H,10H2,(H2,28,33)(H,30,34) JWWMHVQQOFJKMF-UHFFFAOYSA-N 226370 US9328096, 63 High affinity nerve growth factor receptor [441-796] Human 145.93 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226370 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226370&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118505210 336293517 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396152 NC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2cccc(OC(F)F)n2)n(n1)-c1ccccc1 InChI=1S/C23H16ClF2N5O3/c24-16-10-9-13(17-7-4-8-20(28-17)34-23(25)26)11-15(16)22(33)29-19-12-18(21(27)32)30-31(19)14-5-2-1-3-6-14/h1-12,23H,(H2,27,32)(H,29,33) WFLJKUWMIHERHW-UHFFFAOYSA-N 226371 US9328096, 64 High affinity nerve growth factor receptor [441-796] Human 2578.12 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226371 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226371&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118505211 336293518 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396153 CNCc1cccc(n1)-c1ccc(Cl)c(c1)C(=O)Nc1cc(nn1-c1ccccc1)C(N)=O InChI=1S/C24H21ClN6O2/c1-27-14-16-6-5-9-20(28-16)15-10-11-19(25)18(12-15)24(33)29-22-13-21(23(26)32)30-31(22)17-7-3-2-4-8-17/h2-13,27H,14H2,1H3,(H2,26,32)(H,29,33) TUYCCCRDVBWRBP-UHFFFAOYSA-N 226372 US9328096, 65 High affinity nerve growth factor receptor [441-796] Human 14329.54 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226372 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226372&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118505213 336293519 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396154 COC(C)c1cccc(n1)-c1ccc(Cl)c(c1)C(=O)Nc1cc(nn1-c1ccccc1)C(N)=O InChI=1S/C25H22ClN5O3/c1-15(34-2)20-9-6-10-21(28-20)16-11-12-19(26)18(13-16)25(33)29-23-14-22(24(27)32)30-31(23)17-7-4-3-5-8-17/h3-15H,1-2H3,(H2,27,32)(H,29,33) VLAXRFXESQCKFW-UHFFFAOYSA-N 226373 US9328096, 66 High affinity nerve growth factor receptor [441-796] Human 8658.01 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226373 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226373&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118506965 336293520 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396155 COCc1ccc(Cl)c(n1)-c1ccc(Cl)c(c1)C(=O)Nc1cc(nn1-c1ccccc1)C(N)=O InChI=1S/C24H19Cl2N5O3/c1-34-13-15-8-10-19(26)22(28-15)14-7-9-18(25)17(11-14)24(33)29-21-12-20(23(27)32)30-31(21)16-5-3-2-4-6-16/h2-12H,13H2,1H3,(H2,27,32)(H,29,33) XFFNWUUJMUDZCP-UHFFFAOYSA-N 226374 US9328096, 67 High affinity nerve growth factor receptor [441-796] Human 114.87 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226374 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226374&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118505215 336293521 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396156 NC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C22H14ClF2N5O2/c23-15-10-17(25)14(20-16(24)7-4-8-27-20)9-13(15)22(32)28-19-11-18(21(26)31)29-30(19)12-5-2-1-3-6-12/h1-11H,(H2,26,31)(H,28,32) FMOSFMZYOIQVNN-UHFFFAOYSA-N 226375 US9328096, 68 High affinity nerve growth factor receptor [441-796] Human 12.87 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226375 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226375&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118497013 336293522 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396157 COCc1ccc(F)c(n1)-c1ccc(Cl)c(c1)C(=O)Nc1cc(nn1-c1ccccc1)C(N)=O InChI=1S/C24H19ClFN5O3/c1-34-13-15-8-10-19(26)22(28-15)14-7-9-18(25)17(11-14)24(33)29-21-12-20(23(27)32)30-31(21)16-5-3-2-4-6-16/h2-12H,13H2,1H3,(H2,27,32)(H,29,33) YGWWJTKIQXIGIP-UHFFFAOYSA-N 226376 US9328096, 69 High affinity nerve growth factor receptor [441-796] Human 44.35 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226376 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226376&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118497030 336293523 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396158 NC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C22H15ClFN5O2/c23-16-9-8-13(20-17(24)7-4-10-26-20)11-15(16)22(31)27-19-12-18(21(25)30)28-29(19)14-5-2-1-3-6-14/h1-12H,(H2,25,30)(H,27,31) WWUFQDBUWSEOPZ-UHFFFAOYSA-N 226377 US9328096, 70 High affinity nerve growth factor receptor [441-796] Human 74.27 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226377 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226377&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118497161 336293524 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396159 CC(=O)Nc1ccc(F)c(n1)-c1ccc(Cl)c(c1)C(=O)Nc1cc(nn1-c1ccccc1)C(N)=O InChI=1S/C24H18ClFN6O3/c1-13(33)28-20-10-9-18(26)22(29-20)14-7-8-17(25)16(11-14)24(35)30-21-12-19(23(27)34)31-32(21)15-5-3-2-4-6-15/h2-12H,1H3,(H2,27,34)(H,30,35)(H,28,29,33) RPIKKEALPAYCDX-UHFFFAOYSA-N 226378 US9328096, 71 High affinity nerve growth factor receptor [441-796] Human 6.13 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226378 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226378&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118497068 336293525 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396160 CC(=O)Nc1cccc(n1)-c1ccc(Cl)c(c1)C(=O)Nc1cc(nn1-c1ccccc1)C(N)=O InChI=1S/C24H19ClN6O3/c1-14(32)27-21-9-5-8-19(28-21)15-10-11-18(25)17(12-15)24(34)29-22-13-20(23(26)33)30-31(22)16-6-3-2-4-7-16/h2-13H,1H3,(H2,26,33)(H,29,34)(H,27,28,32) FARAYTFPQFYYFB-UHFFFAOYSA-N 226379 US9328096, 72 High affinity nerve growth factor receptor [441-796] Human 20.83 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226379 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226379&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118497113 336293526 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396161 NC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2Cl)n(n1)-c1ccccc1 InChI=1S/C22H15Cl2N5O2/c23-16-9-8-13(20-17(24)7-4-10-26-20)11-15(16)22(31)27-19-12-18(21(25)30)28-29(19)14-5-2-1-3-6-14/h1-12H,(H2,25,30)(H,27,31) JINWGFDGNSERPK-UHFFFAOYSA-N 226380 US9328096, 73 High affinity nerve growth factor receptor [441-796] Human 105.38 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226380 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226380&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118505217 336293527 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396162 NC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncc(F)cc2Cl)n(n1)-c1ccccc1 InChI=1S/C22H14Cl2FN5O2/c23-16-7-6-12(20-17(24)9-13(25)11-27-20)8-15(16)22(32)28-19-10-18(21(26)31)29-30(19)14-4-2-1-3-5-14/h1-11H,(H2,26,31)(H,28,32) WMUKTRLOVLSAME-UHFFFAOYSA-N 226381 US9328096, 74 High affinity nerve growth factor receptor [441-796] Human 341.92 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226381 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226381&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118505216 336293528 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396163 CNc1cccc(n1)-c1ccc(Cl)c(c1)C(=O)Nc1cc(nn1-c1ccccc1)C(N)=O InChI=1S/C23H19ClN6O2/c1-26-20-9-5-8-18(27-20)14-10-11-17(24)16(12-14)23(32)28-21-13-19(22(25)31)29-30(21)15-6-3-2-4-7-15/h2-13H,1H3,(H2,25,31)(H,26,27)(H,28,32) KPCIJCBAYWSXKX-UHFFFAOYSA-N 226382 US9328096, 75 High affinity nerve growth factor receptor [441-796] Human 171.84 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226382 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226382&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118505218 336293529 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396164 NC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2cccc(n2)C(N)=O)n(n1)-c1ccccc1 InChI=1S/C23H17ClN6O3/c24-16-10-9-13(17-7-4-8-18(27-17)21(25)31)11-15(16)23(33)28-20-12-19(22(26)32)29-30(20)14-5-2-1-3-6-14/h1-12H,(H2,25,31)(H2,26,32)(H,28,33) VXLKAHXNBSRIAM-UHFFFAOYSA-N 226383 US9328096, 76 High affinity nerve growth factor receptor [441-796] Human 50000 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226383 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226383&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118505219 336293530 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396165 NC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncc(F)cc2F)n(n1)-c1ccccc1 InChI=1S/C22H14ClF2N5O2/c23-16-7-6-12(20-17(25)9-13(24)11-27-20)8-15(16)22(32)28-19-10-18(21(26)31)29-30(19)14-4-2-1-3-5-14/h1-11H,(H2,26,31)(H,28,32) JVZAFJOUZGTMDX-UHFFFAOYSA-N 226384 US9328096, 77 High affinity nerve growth factor receptor [441-796] Human 136.65 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226384 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226384&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118505220 336293531 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396166 NC(=O)c1cc(NC(=O)c2cc(cc(F)c2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C22H14ClF2N5O2/c23-19-14(9-12(10-16(19)25)20-15(24)7-4-8-27-20)22(32)28-18-11-17(21(26)31)29-30(18)13-5-2-1-3-6-13/h1-11H,(H2,26,31)(H,28,32) FCJYEAIULOJYKB-UHFFFAOYSA-N 226385 US9328096, 78 High affinity nerve growth factor receptor [441-796] Human 67.65 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226385 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226385&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118505221 336293532 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396167 NC(=O)c1cc(NC(=O)c2c(Cl)ccc(c2F)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C22H14ClF2N5O2/c23-14-9-8-13(20-15(24)7-4-10-27-20)19(25)18(14)22(32)28-17-11-16(21(26)31)29-30(17)12-5-2-1-3-6-12/h1-11H,(H2,26,31)(H,28,32) ACJSEGGAYCWDAC-UHFFFAOYSA-N 226386 US9328096, 79 High affinity nerve growth factor receptor [441-796] Human 1975.64 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226386 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226386&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118505222 336293533 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396168 Cc1cc(Cl)c(cc1-c1ccccn1)C(=O)Nc1cc(nn1-c1ccccc1)C(N)=O InChI=1S/C23H18ClN5O2/c1-14-11-18(24)17(12-16(14)19-9-5-6-10-26-19)23(31)27-21-13-20(22(25)30)28-29(21)15-7-3-2-4-8-15/h2-13H,1H3,(H2,25,30)(H,27,31) KCLUHVZXIYSCNX-UHFFFAOYSA-N 226387 US9328096, 80 High affinity nerve growth factor receptor [441-796] Human 42.96 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226387 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226387&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118505223 336293534 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396169 NC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C22H15ClFN5O2/c23-16-11-17(24)15(18-8-4-5-9-26-18)10-14(16)22(31)27-20-12-19(21(25)30)28-29(20)13-6-2-1-3-7-13/h1-12H,(H2,25,30)(H,27,31) LYUWFBBAMQKLEL-UHFFFAOYSA-N 226388 US9328096, 81 High affinity nerve growth factor receptor [441-796] Human 41.62 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226388 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226388&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118505224 336293535 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396170 COc1cc(Cl)c(cc1-c1ccccn1)C(=O)Nc1cc(nn1-c1ccccc1)C(N)=O InChI=1S/C23H18ClN5O3/c1-32-20-12-17(24)15(11-16(20)18-9-5-6-10-26-18)23(31)27-21-13-19(22(25)30)28-29(21)14-7-3-2-4-8-14/h2-13H,1H3,(H2,25,30)(H,27,31) REEUULZARVBYQG-UHFFFAOYSA-N 226389 US9328096, 82 High affinity nerve growth factor receptor [441-796] Human 141.3 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226389 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226389&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118507004 336293536 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396171 Fc1cccnc1-c1ccc(Cl)c(c1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NC1CC1 InChI=1S/C25H19ClFN5O2/c26-19-11-8-15(23-20(27)7-4-12-28-23)13-18(19)24(33)30-22-14-21(25(34)29-16-9-10-16)31-32(22)17-5-2-1-3-6-17/h1-8,11-14,16H,9-10H2,(H,29,34)(H,30,33) XNNJXJZBITWQTD-UHFFFAOYSA-N 226390 US9328096, 83 High affinity nerve growth factor receptor [441-796] Human 40.64 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226390 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226390&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118497029 336293537 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396172 Clc1ccc(cc1C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NC1CC1)-c1ncccc1C#N InChI=1S/C26H19ClN6O2/c27-21-11-8-16(24-17(15-28)5-4-12-29-24)13-20(21)25(34)31-23-14-22(26(35)30-18-9-10-18)32-33(23)19-6-2-1-3-7-19/h1-8,11-14,18H,9-10H2,(H,30,35)(H,31,34) OZETYNUYVHTOGB-UHFFFAOYSA-N 226391 US9328096, 84 High affinity nerve growth factor receptor [441-796] Human 440.2 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226391 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226391&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118497170 336293538 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396173 NC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1cccc(O)c1 InChI=1S/C22H15ClFN5O3/c23-16-7-6-12(20-17(24)5-2-8-26-20)9-15(16)22(32)27-19-11-18(21(25)31)28-29(19)13-3-1-4-14(30)10-13/h1-11,30H,(H2,25,31)(H,27,32) JEFNBYNYZISWNT-UHFFFAOYSA-N 226392 US9328096, 85 High affinity nerve growth factor receptor [441-796] Human 24.4 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226392 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226392&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118497136 336293539 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396174 OCCNC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1cccc(O)c1 InChI=1S/C24H19ClFN5O4/c25-18-7-6-14(22-19(26)5-2-8-27-22)11-17(18)23(34)29-21-13-20(24(35)28-9-10-32)30-31(21)15-3-1-4-16(33)12-15/h1-8,11-13,32-33H,9-10H2,(H,28,35)(H,29,34) QRGGSEOXQBSHAR-UHFFFAOYSA-N 226393 US9328096, 86 High affinity nerve growth factor receptor [441-796] Human 89.12 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226393 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226393&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118497047 336293540 C04080 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396175 Oc1cccc(c1)-n1nc(cc1NC(=O)c1cc(ccc1Cl)-c1ncccc1F)C(=O)NC1CC1 InChI=1S/C25H19ClFN5O3/c26-19-9-6-14(23-20(27)5-2-10-28-23)11-18(19)24(34)30-22-13-21(25(35)29-15-7-8-15)31-32(22)16-3-1-4-17(33)12-16/h1-6,9-13,15,33H,7-8H2,(H,29,35)(H,30,34) ZNMIXDLLNHQYLH-UHFFFAOYSA-N 226394 US9328096, 87 High affinity nerve growth factor receptor [441-796] Human 8.09 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226394 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226394&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118497144 336293541 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396176 OC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C22H14ClFN4O3/c23-16-9-8-13(20-17(24)7-4-10-25-20)11-15(16)21(29)26-19-12-18(22(30)31)27-28(19)14-5-2-1-3-6-14/h1-12H,(H,26,29)(H,30,31) XWQOBGOAOQZGEI-UHFFFAOYSA-N 226412 US9328096, 105 High affinity nerve growth factor receptor [441-796] Human 8036 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226412 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226412&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118497109 336293542 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396177 CC(C)(C)CNC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C27H24Cl2FN5O2/c1-27(2,3)15-32-26(37)22-14-23(35(34-22)16-8-5-4-6-9-16)33-25(36)18-12-17(19(28)13-20(18)29)24-21(30)10-7-11-31-24/h4-14H,15H2,1-3H3,(H,32,37)(H,33,36) KIAQIIDWTXPHEE-UHFFFAOYSA-N 226441 US9328096, 134 High affinity nerve growth factor receptor [441-796] Human 4.61 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226441 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226441&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118505229 336293543 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396178 OCCNC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C24H19ClFN5O3/c25-18-13-19(26)17(20-8-4-5-9-27-20)12-16(18)23(33)29-22-14-21(24(34)28-10-11-32)30-31(22)15-6-2-1-3-7-15/h1-9,12-14,32H,10-11H2,(H,28,34)(H,29,33) SXCWMOYPOJNZAD-UHFFFAOYSA-N 226442 US9328096, 135 High affinity nerve growth factor receptor [441-796] Human 25.3 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226442 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226442&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118497046 336293544 C04080 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396179 OP(O)(=O)OCCNC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C24H20ClFN5O6P/c25-18-13-19(26)17(20-8-4-5-9-27-20)12-16(18)23(32)29-22-14-21(24(33)28-10-11-37-38(34,35)36)30-31(22)15-6-2-1-3-7-15/h1-9,12-14H,10-11H2,(H,28,33)(H,29,32)(H2,34,35,36) QNSCVMKDBCGFJJ-UHFFFAOYSA-N 226443 US9328096, 136 High affinity nerve growth factor receptor [441-796] Human 1570 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226443 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226443&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118497020 336293545 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396180 CNC(=O)C1(CC1)NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C27H21Cl2FN6O3/c1-31-26(39)27(9-10-27)34-25(38)21-14-22(36(35-21)15-6-3-2-4-7-15)33-24(37)17-12-16(18(28)13-19(17)29)23-20(30)8-5-11-32-23/h2-8,11-14H,9-10H2,1H3,(H,31,39)(H,33,37)(H,34,38) FKRJSTMHNXQNLL-UHFFFAOYSA-N 226444 US9328096, 137 High affinity nerve growth factor receptor [441-796] Human 9.3 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226444 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226444&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118497057 336293546 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396181 Nc1ccc(CNC(=O)c2cc(NC(=O)c3cc(c(F)cc3Cl)-c3ccccn3)n(n2)-c2ccccc2)cn1 InChI=1S/C28H21ClFN7O2/c29-21-13-22(30)20(23-8-4-5-11-32-23)12-19(21)27(38)35-26-14-24(36-37(26)18-6-2-1-3-7-18)28(39)34-16-17-9-10-25(31)33-15-17/h1-15H,16H2,(H2,31,33)(H,34,39)(H,35,38) DVNATNJWHUNPIE-UHFFFAOYSA-N 226445 US9328096, 138 High affinity nerve growth factor receptor [441-796] Human 3.41 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226445 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226445&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962605 336293547 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396182 OP(O)(=O)OCCNC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C24H19Cl2FN5O6P/c25-17-12-18(26)16(11-15(17)22-19(27)7-4-8-28-22)23(33)30-21-13-20(24(34)29-9-10-38-39(35,36)37)31-32(21)14-5-2-1-3-6-14/h1-8,11-13H,9-10H2,(H,29,34)(H,30,33)(H2,35,36,37) FZYJFSFMCFCTLJ-UHFFFAOYSA-N 226446 US9328096, 139 High affinity nerve growth factor receptor [441-796] Human 667 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226446 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226446&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962606 336293548 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396183 OCCNC(=O)c1cc(NC(=O)c2cc(-c3ccccn3)c(cc2Cl)C(F)(F)F)n(n1)-c1ccccc1 InChI=1S/C25H19ClF3N5O3/c26-19-13-18(25(27,28)29)16(20-8-4-5-9-30-20)12-17(19)23(36)32-22-14-21(24(37)31-10-11-35)33-34(22)15-6-2-1-3-7-15/h1-9,12-14,35H,10-11H2,(H,31,37)(H,32,36) AJAIIHXDXVNPCD-UHFFFAOYSA-N 226447 US9328096, 140 High affinity nerve growth factor receptor [441-796] Human 29.5 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226447 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226447&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962607 336293549 C04080 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396184 NC1(CNC(=O)c2cc(NC(=O)c3cc(c(Cl)cc3Cl)-c3ncccc3F)n(n2)-c2ccccc2)COC1 InChI=1S/C26H21Cl2FN6O3/c27-18-10-19(28)17(9-16(18)23-20(29)7-4-8-31-23)24(36)33-22-11-21(25(37)32-12-26(30)13-38-14-26)34-35(22)15-5-2-1-3-6-15/h1-11H,12-14,30H2,(H,32,37)(H,33,36) CEBWKNFKYUZVKK-UHFFFAOYSA-N 226448 US9328096, 141 High affinity nerve growth factor receptor [441-796] Human 10.6 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226448 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226448&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962608 336293550 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396185 Fc1cc(Cl)c(cc1-c1ncccc1F)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NC1COC1 InChI=1S/C25H18ClF2N5O3/c26-18-10-20(28)17(23-19(27)7-4-8-29-23)9-16(18)24(34)31-22-11-21(25(35)30-14-12-36-13-14)32-33(22)15-5-2-1-3-6-15/h1-11,14H,12-13H2,(H,30,35)(H,31,34) RKHSSNPZCQXCAJ-UHFFFAOYSA-N 226449 US9328096, 142 High affinity nerve growth factor receptor [441-796] Human 18.4 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226449 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226449&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962609 336293551 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396186 O[C@H]1COC[C@@H]1NC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C26H20ClF2N5O4/c27-17-10-19(29)16(24-18(28)7-4-8-30-24)9-15(17)25(36)32-23-11-20(26(37)31-21-12-38-13-22(21)35)33-34(23)14-5-2-1-3-6-14/h1-11,21-22,35H,12-13H2,(H,31,37)(H,32,36)/t21-,22-/m0/s1 YKWMLKMCCVRPQI-VXKWHMMOSA-N 226450 US9328096, 143 High affinity nerve growth factor receptor [441-796] Human 15.7 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226450 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226450&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962610 336293552 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396187 O[C@@H]1COCC[C@H]1NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C27H22Cl2FN5O4/c28-18-12-19(29)17(11-16(18)25-20(30)7-4-9-31-25)26(37)33-24-13-22(34-35(24)15-5-2-1-3-6-15)27(38)32-21-8-10-39-14-23(21)36/h1-7,9,11-13,21,23,36H,8,10,14H2,(H,32,38)(H,33,37)/t21-,23-/m1/s1 QZQXSJQEGUPVFM-FYYLOGMGSA-N 226451 US9328096, 144 High affinity nerve growth factor receptor [441-796] Human 7.1 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226451 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226451&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962611 336293553 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396188 Fc1cccnc1-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)N2CCNCC2)c(Cl)cc1Cl InChI=1S/C26H21Cl2FN6O2/c27-19-14-20(28)18(13-17(19)24-21(29)7-4-8-31-24)25(36)32-23-15-22(26(37)34-11-9-30-10-12-34)33-35(23)16-5-2-1-3-6-16/h1-8,13-15,30H,9-12H2,(H,32,36) OSJGXHBHEDLGID-UHFFFAOYSA-N 226452 US9328096, 145 High affinity nerve growth factor receptor [441-796] Human 42.6 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226452 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226452&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962612 336293554 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396189 COc1cc(Cl)c(cc1-c1ccccn1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)Nc1c(C)n[nH]c1C InChI=1S/C28H24ClN7O3/c1-16-26(17(2)34-33-16)32-28(38)23-15-25(36(35-23)18-9-5-4-6-10-18)31-27(37)19-13-20(22-11-7-8-12-30-22)24(39-3)14-21(19)29/h4-15H,1-3H3,(H,31,37)(H,32,38)(H,33,34) HFVCXOLMNPWOIQ-UHFFFAOYSA-N 226453 US9328096, 146 High affinity nerve growth factor receptor [441-796] Human 26.4 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226453 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226453&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962613 336293555 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396190 Nc1[nH]ncc1CNC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C26H19Cl2FN8O2/c27-18-10-19(28)17(9-16(18)23-20(29)7-4-8-31-23)25(38)34-22-11-21(36-37(22)15-5-2-1-3-6-15)26(39)32-12-14-13-33-35-24(14)30/h1-11,13H,12H2,(H,32,39)(H,34,38)(H3,30,33,35) WUZYTGNPHQFZQZ-UHFFFAOYSA-N 226454 US9328096, 147 High affinity nerve growth factor receptor [441-796] Human 12.3 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226454 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226454&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962614 336293556 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396191 Cc1cc(Cl)c(cc1-c1ncccc1F)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCC(C)(C)O InChI=1S/C27H25ClFN5O3/c1-16-12-20(28)19(13-18(16)24-21(29)10-7-11-30-24)25(35)32-23-14-22(26(36)31-15-27(2,3)37)33-34(23)17-8-5-4-6-9-17/h4-14,37H,15H2,1-3H3,(H,31,36)(H,32,35) XFIKPYISCBWPLE-UHFFFAOYSA-N 226455 US9328096, 148 High affinity nerve growth factor receptor [441-796] Human 9.67 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226455 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226455&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962615 336293557 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396192 Cc1cc(Cl)c(cc1-c1ncccc1F)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCCN InChI=1S/C25H22ClFN6O2/c1-15-12-19(26)18(13-17(15)23-20(27)8-5-10-29-23)24(34)31-22-14-21(25(35)30-11-9-28)32-33(22)16-6-3-2-4-7-16/h2-8,10,12-14H,9,11,28H2,1H3,(H,30,35)(H,31,34) OIVGZILOWXYJLO-UHFFFAOYSA-N 226456 US9328096, 149 High affinity nerve growth factor receptor [441-796] Human 20.2 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226456 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226456&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962616 336293558 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396193 COc1cc(Cl)c(cc1-c1ncccc1F)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCc1cn[nH]c1 InChI=1S/C27H21ClFN7O3/c1-39-23-11-20(28)18(10-19(23)25-21(29)8-5-9-30-25)26(37)34-24-12-22(27(38)31-13-16-14-32-33-15-16)35-36(24)17-6-3-2-4-7-17/h2-12,14-15H,13H2,1H3,(H,31,38)(H,32,33)(H,34,37) IVNLJKKLKYLCAD-UHFFFAOYSA-N 226457 US9328096, 150 High affinity nerve growth factor receptor [441-796] Human 10.3 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226457 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226457&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962617 336293559 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396194 Nc1ccc(CNC(=O)c2cc(NC(=O)c3cc(c(F)cc3Cl)-c3ncccc3F)n(n2)-c2ccccc2)cn1 InChI=1S/C28H20ClF2N7O2/c29-20-12-22(31)19(26-21(30)7-4-10-33-26)11-18(20)27(39)36-25-13-23(37-38(25)17-5-2-1-3-6-17)28(40)35-15-16-8-9-24(32)34-14-16/h1-14H,15H2,(H2,32,34)(H,35,40)(H,36,39) WIOBEOQJKWIGQL-UHFFFAOYSA-N 226458 US9328096, 151 High affinity nerve growth factor receptor [441-796] Human 2.98 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226458 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226458&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962618 336293560 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396195 O[C@H]1COC[C@@H]1NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C26H20Cl2FN5O4/c27-17-10-18(28)16(9-15(17)24-19(29)7-4-8-30-24)25(36)32-23-11-20(26(37)31-21-12-38-13-22(21)35)33-34(23)14-5-2-1-3-6-14/h1-11,21-22,35H,12-13H2,(H,31,37)(H,32,36)/t21-,22-/m0/s1 UAQDSJPRSQHMJN-VXKWHMMOSA-N 226459 US9328096, 152 High affinity nerve growth factor receptor [441-796] Human 6.16 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226459 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226459&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962619 336293561 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396196 O[C@@H]1COC[C@H]1NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C26H20Cl2FN5O4/c27-17-10-18(28)16(9-15(17)24-19(29)7-4-8-30-24)25(36)32-23-11-20(26(37)31-21-12-38-13-22(21)35)33-34(23)14-5-2-1-3-6-14/h1-11,21-22,35H,12-13H2,(H,31,37)(H,32,36)/t21-,22-/m1/s1 UAQDSJPRSQHMJN-FGZHOGPDSA-N 226460 US9328096, 153 High affinity nerve growth factor receptor [441-796] Human 4.72 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226460 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226460&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962620 336293562 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396197 Fc1cccnc1-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)N2CCNC(=O)C2)c(Cl)cc1Cl InChI=1S/C26H19Cl2FN6O3/c27-18-12-19(28)17(11-16(18)24-20(29)7-4-8-31-24)25(37)32-22-13-21(26(38)34-10-9-30-23(36)14-34)33-35(22)15-5-2-1-3-6-15/h1-8,11-13H,9-10,14H2,(H,30,36)(H,32,37) YOMGIOXFMDKEQS-UHFFFAOYSA-N 226461 US9328096, 154 High affinity nerve growth factor receptor [441-796] Human 13.7 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226461 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226461&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 121297535 336293563 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396198 Cn1nc(N)cc1CNC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C27H21Cl2FN8O2/c1-37-16(10-23(31)36-37)14-33-27(40)22-13-24(38(35-22)15-6-3-2-4-7-15)34-26(39)18-11-17(19(28)12-20(18)29)25-21(30)8-5-9-32-25/h2-13H,14H2,1H3,(H2,31,36)(H,33,40)(H,34,39) ZGMDLWFCZFLTJD-UHFFFAOYSA-N 226462 US9328096, 155 High affinity nerve growth factor receptor [441-796] Human 7.91 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226462 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226462&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962621 336293564 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396199 Nc1n[nH]cc1CNC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C26H19ClF2N8O2/c27-18-10-20(29)17(23-19(28)7-4-8-31-23)9-16(18)25(38)34-22-11-21(36-37(22)15-5-2-1-3-6-15)26(39)32-12-14-13-33-35-24(14)30/h1-11,13H,12H2,(H,32,39)(H,34,38)(H3,30,33,35) NXGAIFDVYPIAOO-UHFFFAOYSA-N 226463 US9328096, 156 High affinity nerve growth factor receptor [441-796] Human 18.6 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226463 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226463&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962622 336293565 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396200 NCCNC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C24H19ClF2N6O2/c25-17-12-19(27)16(22-18(26)7-4-9-29-22)11-15(17)23(34)31-21-13-20(24(35)30-10-8-28)32-33(21)14-5-2-1-3-6-14/h1-7,9,11-13H,8,10,28H2,(H,30,35)(H,31,34) IDKQUMURVQLNFM-UHFFFAOYSA-N 226464 US9328096, 157 High affinity nerve growth factor receptor [441-796] Human 45.3 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226464 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226464&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962623 336293566 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396201 Cc1ncc(CNC(=O)c2cc(NC(=O)c3cc(c(Cl)cc3Cl)-c3ncccc3F)n(n2)-c2ccccc2)[nH]1 InChI=1S/C27H20Cl2FN7O2/c1-15-32-13-16(34-15)14-33-27(39)23-12-24(37(36-23)17-6-3-2-4-7-17)35-26(38)19-10-18(20(28)11-21(19)29)25-22(30)8-5-9-31-25/h2-13H,14H2,1H3,(H,32,34)(H,33,39)(H,35,38) VHUKFMHSLVEFPV-UHFFFAOYSA-N 226465 US9328096, 158 High affinity nerve growth factor receptor [441-796] Human 4.71 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226465 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226465&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962624 336293567 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396202 Fc1cccnc1-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)NC2CNC2)c(Cl)cc1Cl InChI=1S/C25H19Cl2FN6O2/c26-18-10-19(27)17(9-16(18)23-20(28)7-4-8-30-23)24(35)32-22-11-21(25(36)31-14-12-29-13-14)33-34(22)15-5-2-1-3-6-15/h1-11,14,29H,12-13H2,(H,31,36)(H,32,35) SJMXZCZPIFWDEK-UHFFFAOYSA-N 226466 US9328096, 159 High affinity nerve growth factor receptor [441-796] Human 189 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226466 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226466&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962625 336293568 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396203 COC[C@H](O)CNC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C26H22Cl2FN5O4/c1-38-14-16(35)13-31-26(37)22-12-23(34(33-22)15-6-3-2-4-7-15)32-25(36)18-10-17(19(27)11-20(18)28)24-21(29)8-5-9-30-24/h2-12,16,35H,13-14H2,1H3,(H,31,37)(H,32,36)/t16-/m1/s1 BJDSQPWQVKMJKG-MRXNPFEDSA-N 226467 US9328096, 160 High affinity nerve growth factor receptor [441-796] Human 8.7 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226467 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226467&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962626 336293569 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396204 OCCOCCNC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C26H22Cl2FN5O4/c27-19-14-20(28)18(13-17(19)24-21(29)7-4-8-30-24)25(36)32-23-15-22(26(37)31-9-11-38-12-10-35)33-34(23)16-5-2-1-3-6-16/h1-8,13-15,35H,9-12H2,(H,31,37)(H,32,36) VTHBDHBVCJJWGW-UHFFFAOYSA-N 226468 US9328096, 161 High affinity nerve growth factor receptor [441-796] Human 9.58 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226468 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226468&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962627 336293570 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396205 COC[C@@H](O)CNC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C26H22Cl2FN5O4/c1-38-14-16(35)13-31-26(37)22-12-23(34(33-22)15-6-3-2-4-7-15)32-25(36)18-10-17(19(27)11-20(18)28)24-21(29)8-5-9-30-24/h2-12,16,35H,13-14H2,1H3,(H,31,37)(H,32,36)/t16-/m0/s1 BJDSQPWQVKMJKG-INIZCTEOSA-N 226469 US9328096, 162 High affinity nerve growth factor receptor [441-796] Human 5.45 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226469 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226469&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962628 336293571 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396206 COC[C@@H](N)CNC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C26H23Cl2FN6O3/c1-38-14-15(30)13-32-26(37)22-12-23(35(34-22)16-6-3-2-4-7-16)33-25(36)18-10-17(19(27)11-20(18)28)24-21(29)8-5-9-31-24/h2-12,15H,13-14,30H2,1H3,(H,32,37)(H,33,36)/t15-/m0/s1 WPZOYAILFKKAEH-HNNXBMFYSA-N 226470 US9328096, 163 High affinity nerve growth factor receptor [441-796] Human 196 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226470 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226470&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962629 336293572 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396207 N[C@H](CO)CNC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C25H21Cl2FN6O3/c26-18-10-19(27)17(9-16(18)23-20(28)7-4-8-30-23)24(36)32-22-11-21(25(37)31-12-14(29)13-35)33-34(22)15-5-2-1-3-6-15/h1-11,14,35H,12-13,29H2,(H,31,37)(H,32,36)/t14-/m0/s1 QPRIHTVOOHVIDJ-AWEZNQCLSA-N 226471 US9328096, 164 High affinity nerve growth factor receptor [441-796] Human 177 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226471 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226471&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962630 336293573 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396208 Cc1n[nH]c(C)c1NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C27H20Cl2FN7O2/c1-14-24(15(2)35-34-14)33-27(39)22-13-23(37(36-22)16-7-4-3-5-8-16)32-26(38)18-11-17(19(28)12-20(18)29)25-21(30)9-6-10-31-25/h3-13H,1-2H3,(H,32,38)(H,33,39)(H,34,35) VEXXAUSRMSHOFS-UHFFFAOYSA-N 226472 US9328096, 165 High affinity nerve growth factor receptor [441-796] Human 2.45 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226472 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226472&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962631 336293574 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396209 OC[C@H](O)CNC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C25H20Cl2FN5O4/c26-18-10-19(27)17(9-16(18)23-20(28)7-4-8-29-23)24(36)31-22-11-21(25(37)30-12-15(35)13-34)32-33(22)14-5-2-1-3-6-14/h1-11,15,34-35H,12-13H2,(H,30,37)(H,31,36)/t15-/m1/s1 VLFOGDAHBXMZER-OAHLLOKOSA-N 226473 US9328096, 166 High affinity nerve growth factor receptor [441-796] Human 13.7 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226473 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226473&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962632 336293575 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396210 OC[C@@H](O)CNC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C25H20Cl2FN5O4/c26-18-10-19(27)17(9-16(18)23-20(28)7-4-8-29-23)24(36)31-22-11-21(25(37)30-12-15(35)13-34)32-33(22)14-5-2-1-3-6-14/h1-11,15,34-35H,12-13H2,(H,30,37)(H,31,36)/t15-/m0/s1 VLFOGDAHBXMZER-HNNXBMFYSA-N 226474 US9328096, 167 High affinity nerve growth factor receptor [441-796] Human 12.9 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226474 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226474&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962633 336293576 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396211 O[C@H]1CC[C@@H](CC1)NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C28H25Cl2N5O3/c29-22-15-23(30)21(14-20(22)24-8-4-5-13-31-24)27(37)33-26-16-25(34-35(26)18-6-2-1-3-7-18)28(38)32-17-9-11-19(36)12-10-17/h1-8,13-17,19,36H,9-12H2,(H,32,38)(H,33,37)/t17-,19- KUNPKIHGQUCMNB-UAPYVXQJSA-N 226475 US9328096, 168 High affinity nerve growth factor receptor [441-796] Human 6.93 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226475 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226475&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 121297534 336293577 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396212 OC1(CNC(=O)c2cc(NC(=O)c3cc(c(Cl)cc3Cl)-c3ncccc3F)n(n2)-c2ccccc2)COC1 InChI=1S/C26H20Cl2FN5O4/c27-18-10-19(28)17(9-16(18)23-20(29)7-4-8-30-23)24(35)32-22-11-21(25(36)31-12-26(37)13-38-14-26)33-34(22)15-5-2-1-3-6-15/h1-11,37H,12-14H2,(H,31,36)(H,32,35) QWTIWTOBTITERI-UHFFFAOYSA-N 226476 US9328096, 169 High affinity nerve growth factor receptor [441-796] Human 4.22 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226476 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226476&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962634 336293578 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396213 O[C@H]1CC[C@@H](CC1)NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C28H24Cl2FN5O3/c29-21-14-22(30)20(13-19(21)26-23(31)7-4-12-32-26)27(38)34-25-15-24(35-36(25)17-5-2-1-3-6-17)28(39)33-16-8-10-18(37)11-9-16/h1-7,12-16,18,37H,8-11H2,(H,33,39)(H,34,38)/t16-,18- XOCPTMXSHPKLKW-SAABIXHNSA-N 226477 US9328096, 170 High affinity nerve growth factor receptor [441-796] Human 4.03 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226477 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226477&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962635 336293579 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396214 NCCNC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C24H19Cl2FN6O2/c25-17-12-18(26)16(11-15(17)22-19(27)7-4-9-29-22)23(34)31-21-13-20(24(35)30-10-8-28)32-33(21)14-5-2-1-3-6-14/h1-7,9,11-13H,8,10,28H2,(H,30,35)(H,31,34) HBMBPZWIDWRVJL-UHFFFAOYSA-N 226478 US9328096, 171 High affinity nerve growth factor receptor [441-796] Human 15.9 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226478 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226478&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962636 336293580 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396215 Nc1cc(CNC(=O)c2cc(NC(=O)c3cc(c(Cl)cc3Cl)-c3ncccc3F)n(n2)-c2ccccc2)[nH]n1 InChI=1S/C26H19Cl2FN8O2/c27-18-11-19(28)17(10-16(18)24-20(29)7-4-8-31-24)25(38)33-23-12-21(36-37(23)15-5-2-1-3-6-15)26(39)32-13-14-9-22(30)35-34-14/h1-12H,13H2,(H,32,39)(H,33,38)(H3,30,34,35) JVYXSZKMENJDGJ-UHFFFAOYSA-N 226479 US9328096, 172 High affinity nerve growth factor receptor [441-796] Human 18.8 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226479 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226479&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962637 336293581 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396216 OC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C22H13Cl2FN4O3/c23-15-10-16(24)14(9-13(15)20-17(25)7-4-8-26-20)21(30)27-19-11-18(22(31)32)28-29(19)12-5-2-1-3-6-12/h1-11H,(H,27,30)(H,31,32) BFRDZONOJMMAGO-UHFFFAOYSA-N 226480 US9328096, 173 High affinity nerve growth factor receptor [441-796] Human 582 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226480 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226480&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118497055 336293582 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396217 Fc1cccnc1-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)NCc2cn[nH]n2)c(Cl)cc1Cl InChI=1S/C25H17Cl2FN8O2/c26-18-10-19(27)17(9-16(18)23-20(28)7-4-8-29-23)24(37)32-22-11-21(25(38)30-12-14-13-31-35-33-14)34-36(22)15-5-2-1-3-6-15/h1-11,13H,12H2,(H,30,38)(H,32,37)(H,31,33,35) CTDWSRVSSUPONL-UHFFFAOYSA-N 226481 US9328096, 174 High affinity nerve growth factor receptor [441-796] Human 2.53 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226481 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226481&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962638 336293583 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396218 Cc1[nH]ncc1CNC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C27H20ClF2N7O2/c1-15-16(14-33-35-15)13-32-27(39)23-12-24(37(36-23)17-6-3-2-4-7-17)34-26(38)18-10-19(22(30)11-20(18)28)25-21(29)8-5-9-31-25/h2-12,14H,13H2,1H3,(H,32,39)(H,33,35)(H,34,38) KXFIYXOTNDVZAM-UHFFFAOYSA-N 226482 US9328096, 175 High affinity nerve growth factor receptor [441-796] Human 12.9 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226482 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226482&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962639 336293584 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396219 Fc1ccc(nc1)-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)NCc2cn[nH]c2)c(Cl)cc1Cl InChI=1S/C26H18Cl2FN7O2/c27-20-9-21(28)19(8-18(20)22-7-6-16(29)14-30-22)25(37)34-24-10-23(26(38)31-11-15-12-32-33-13-15)35-36(24)17-4-2-1-3-5-17/h1-10,12-14H,11H2,(H,31,38)(H,32,33)(H,34,37) GPYHATKQXSOGBR-UHFFFAOYSA-N 226483 US9328096, 176 High affinity nerve growth factor receptor [441-796] Human 2.6 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226483 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226483&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962640 336293585 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396220 Fc1ccc(nc1)-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)NCc2cn[nH]c2)c(Cl)cc1F InChI=1S/C26H18ClF2N7O2/c27-20-9-21(29)19(22-7-6-16(28)14-30-22)8-18(20)25(37)34-24-10-23(26(38)31-11-15-12-32-33-13-15)35-36(24)17-4-2-1-3-5-17/h1-10,12-14H,11H2,(H,31,38)(H,32,33)(H,34,37) GIJAEQJEJJVPGD-UHFFFAOYSA-N 226484 US9328096, 177 High affinity nerve growth factor receptor [441-796] Human 4.91 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226484 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226484&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962641 336293586 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396221 Fc1cc(Cl)c(cc1-c1ccccn1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCc1cn[nH]c1 InChI=1S/C26H19ClFN7O2/c27-20-11-21(28)19(22-8-4-5-9-29-22)10-18(20)25(36)33-24-12-23(26(37)30-13-16-14-31-32-15-16)34-35(24)17-6-2-1-3-7-17/h1-12,14-15H,13H2,(H,30,37)(H,31,32)(H,33,36) XHKVIFAQZLZDOC-UHFFFAOYSA-N 226485 US9328096, 178 High affinity nerve growth factor receptor [441-796] Human 3.05 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226485 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226485&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962642 336293587 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396222 Fc1cccnc1-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)NCc2cn[nH]c2)c(Cl)cc1Cl InChI=1S/C26H18Cl2FN7O2/c27-19-10-20(28)18(9-17(19)24-21(29)7-4-8-30-24)25(37)34-23-11-22(26(38)31-12-15-13-32-33-14-15)35-36(23)16-5-2-1-3-6-16/h1-11,13-14H,12H2,(H,31,38)(H,32,33)(H,34,37) VVXAGXOXEVFHMO-UHFFFAOYSA-N 226486 US9328096, 179 High affinity nerve growth factor receptor [441-796] Human 1.74 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226486 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226486&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962643 336293588 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396223 Fc1cccnc1-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)NCc2cc[nH]n2)c(Cl)cc1Cl InChI=1S/C26H18Cl2FN7O2/c27-19-12-20(28)18(11-17(19)24-21(29)7-4-9-30-24)25(37)33-23-13-22(26(38)31-14-15-8-10-32-34-15)35-36(23)16-5-2-1-3-6-16/h1-13H,14H2,(H,31,38)(H,32,34)(H,33,37) IBAZHZMKOHEYPF-UHFFFAOYSA-N 226487 US9328096, 180 High affinity nerve growth factor receptor [441-796] Human 2.8 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226487 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226487&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962644 336293589 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396224 OC1(CNC(=O)c2cc(NC(=O)c3cc(c(Cl)cc3Cl)-c3ccccn3)n(n2)-c2ccccc2)COC1 InChI=1S/C26H21Cl2N5O4/c27-19-11-20(28)18(10-17(19)21-8-4-5-9-29-21)24(34)31-23-12-22(25(35)30-13-26(36)14-37-15-26)32-33(23)16-6-2-1-3-7-16/h1-12,36H,13-15H2,(H,30,35)(H,31,34) NVTAPNWJKVNYCR-UHFFFAOYSA-N 226488 US9328096, 181 High affinity nerve growth factor receptor [441-796] Human 8.71 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226488 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226488&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962645 336293590 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396225 OCC1(COC1)NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C26H21Cl2N5O4/c27-19-11-20(28)18(10-17(19)21-8-4-5-9-29-21)24(35)30-23-12-22(25(36)31-26(13-34)14-37-15-26)32-33(23)16-6-2-1-3-7-16/h1-12,34H,13-15H2,(H,30,35)(H,31,36) HTWRBHABOOHVLN-UHFFFAOYSA-N 226489 US9328096, 182 High affinity nerve growth factor receptor [441-796] Human 18.1 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226489 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226489&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962646 336293591 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396226 OC1(CNC(=O)c2cc(NC(=O)c3cc(c(F)cc3Cl)-c3ncccc3F)n(n2)-c2ccccc2)COC1 InChI=1S/C26H20ClF2N5O4/c27-18-10-20(29)17(23-19(28)7-4-8-30-23)9-16(18)24(35)32-22-11-21(25(36)31-12-26(37)13-38-14-26)33-34(22)15-5-2-1-3-6-15/h1-11,37H,12-14H2,(H,31,36)(H,32,35) HXCXVGOBKZXGGR-UHFFFAOYSA-N 226490 US9328096, 183 High affinity nerve growth factor receptor [441-796] Human 12.6 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226490 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226490&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962647 336293592 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396227 NC1(CNC(=O)c2cc(NC(=O)c3cc(c(Cl)cc3Cl)-c3ccccn3)n(n2)-c2ccccc2)COC1 InChI=1S/C26H22Cl2N6O3/c27-19-11-20(28)18(10-17(19)21-8-4-5-9-30-21)24(35)32-23-12-22(25(36)31-13-26(29)14-37-15-26)33-34(23)16-6-2-1-3-7-16/h1-12H,13-15,29H2,(H,31,36)(H,32,35) LPUVZYXXROMNGZ-UHFFFAOYSA-N 226491 US9328096, 184 High affinity nerve growth factor receptor [441-796] Human 24.9 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226491 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226491&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962648 336293593 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396228 NC(=O)c1cc(NC(=O)c2cc(c(OC(F)F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C23H16ClF2N5O3/c24-16-11-19(34-23(25)26)15(17-8-4-5-9-28-17)10-14(16)22(33)29-20-12-18(21(27)32)30-31(20)13-6-2-1-3-7-13/h1-12,23H,(H2,27,32)(H,29,33) VOYIOQNFFXBOPL-UHFFFAOYSA-N 226492 US9328096, 185 High affinity nerve growth factor receptor [441-796] Human 340 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226492 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226492&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962649 336293594 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396229 NC(=O)c1cc(NC(=O)c2cc(-c3ccccn3)c(cc2Cl)C2CC2)n(n1)-c1ccccc1 InChI=1S/C25H20ClN5O2/c26-20-13-17(15-9-10-15)18(21-8-4-5-11-28-21)12-19(20)25(33)29-23-14-22(24(27)32)30-31(23)16-6-2-1-3-7-16/h1-8,11-15H,9-10H2,(H2,27,32)(H,29,33) TUOHPXSGIUGQKB-UHFFFAOYSA-N 226493 US9328096, 186 High affinity nerve growth factor receptor [441-796] Human 93.3 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226493 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226493&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962650 336293595 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396230 Clc1cc(Cl)c(cc1C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCc1ccno1)-c1ccccn1 InChI=1S/C26H18Cl2N6O3/c27-20-13-21(28)19(12-18(20)22-8-4-5-10-29-22)25(35)32-24-14-23(26(36)30-15-17-9-11-31-37-17)33-34(24)16-6-2-1-3-7-16/h1-14H,15H2,(H,30,36)(H,32,35) OBKCKQUPQOJTON-UHFFFAOYSA-N 226494 US9328096, 187 High affinity nerve growth factor receptor [441-796] Human 4.67 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226494 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226494&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962651 336293596 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396231 FC1(CNC(=O)c2cc(NC(=O)c3cc(c(Cl)cc3Cl)-c3ccccn3)n(n2)-c2ccccc2)COC1 InChI=1S/C26H20Cl2FN5O3/c27-19-11-20(28)18(10-17(19)21-8-4-5-9-30-21)24(35)32-23-12-22(25(36)31-13-26(29)14-37-15-26)33-34(23)16-6-2-1-3-7-16/h1-12H,13-15H2,(H,31,36)(H,32,35) ZZBLBLQKZWBGBJ-UHFFFAOYSA-N 226495 US9328096, 188 High affinity nerve growth factor receptor [441-796] Human 10.1 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226495 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226495&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962652 336293597 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396232 Cn1nncc1CNC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C26H20Cl2N8O2/c1-35-17(15-31-34-35)14-30-26(38)23-13-24(36(33-23)16-7-3-2-4-8-16)32-25(37)19-11-18(20(27)12-21(19)28)22-9-5-6-10-29-22/h2-13,15H,14H2,1H3,(H,30,38)(H,32,37) CGIHMOKEQVISGJ-UHFFFAOYSA-N 226496 US9328096, 189 High affinity nerve growth factor receptor [441-796] Human 12.1 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226496 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226496&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962653 336293598 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396233 NC(=O)CNC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C24H18Cl2N6O3/c25-17-11-18(26)16(10-15(17)19-8-4-5-9-28-19)23(34)30-22-12-20(24(35)29-13-21(27)33)31-32(22)14-6-2-1-3-7-14/h1-12H,13H2,(H2,27,33)(H,29,35)(H,30,34) IOQZPFNVVIDZEM-UHFFFAOYSA-N 226497 US9328096, 190 High affinity nerve growth factor receptor [441-796] Human 22.6 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226497 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226497&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962654 336293599 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396234 OC1(CNC(=O)c2cc(NC(=O)c3cc(c(Cl)cc3Cl)-c3ccccn3)n(n2)-c2ccccc2)CC1 InChI=1S/C26H21Cl2N5O3/c27-19-13-20(28)18(12-17(19)21-8-4-5-11-29-21)24(34)31-23-14-22(25(35)30-15-26(36)9-10-26)32-33(23)16-6-2-1-3-7-16/h1-8,11-14,36H,9-10,15H2,(H,30,35)(H,31,34) NRRGOIMJGNHDNY-UHFFFAOYSA-N 226498 US9328096, 191 High affinity nerve growth factor receptor [441-796] Human 10.6 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226498 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226498&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962655 336293600 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396235 CNC(=O)CNC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C25H20Cl2N6O3/c1-28-23(34)14-30-25(36)21-13-22(33(32-21)15-7-3-2-4-8-15)31-24(35)17-11-16(18(26)12-19(17)27)20-9-5-6-10-29-20/h2-13H,14H2,1H3,(H,28,34)(H,30,36)(H,31,35) SIFVXNPTBHMFJI-UHFFFAOYSA-N 226499 US9328096, 192 High affinity nerve growth factor receptor [441-796] Human 19.7 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226499 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226499&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962656 336293601 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396236 CC(C)(O)CCNC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C27H25Cl2N5O3/c1-27(2,37)11-13-31-26(36)23-16-24(34(33-23)17-8-4-3-5-9-17)32-25(35)19-14-18(20(28)15-21(19)29)22-10-6-7-12-30-22/h3-10,12,14-16,37H,11,13H2,1-2H3,(H,31,36)(H,32,35) PKUSITHAADPABS-UHFFFAOYSA-N 226500 US9328096, 193 High affinity nerve growth factor receptor [441-796] Human 13 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226500 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226500&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962657 336293602 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396237 Clc1cc(Cl)c(cc1C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCC1COC1)-c1ccccn1 InChI=1S/C26H21Cl2N5O3/c27-20-11-21(28)19(10-18(20)22-8-4-5-9-29-22)25(34)31-24-12-23(26(35)30-13-16-14-36-15-16)32-33(24)17-6-2-1-3-7-17/h1-12,16H,13-15H2,(H,30,35)(H,31,34) KRKRNKSVENHBDC-UHFFFAOYSA-N 226501 US9328096, 194 High affinity nerve growth factor receptor [441-796] Human 12.1 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226501 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226501&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962658 336293603 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396238 Clc1cc(Cl)c(cc1C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NC1COC1)-c1ccccn1 InChI=1S/C25H19Cl2N5O3/c26-19-11-20(27)18(10-17(19)21-8-4-5-9-28-21)24(33)30-23-12-22(25(34)29-15-13-35-14-15)31-32(23)16-6-2-1-3-7-16/h1-12,15H,13-14H2,(H,29,34)(H,30,33) IVYVVPAINZAEEL-UHFFFAOYSA-N 226502 US9328096, 195 High affinity nerve growth factor receptor [441-796] Human 9.9 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226502 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226502&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962659 336293604 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396239 CC1(O)CCC(CC1)NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C29H27Cl2N5O3/c1-29(39)12-10-18(11-13-29)33-28(38)25-17-26(36(35-25)19-7-3-2-4-8-19)34-27(37)21-15-20(22(30)16-23(21)31)24-9-5-6-14-32-24/h2-9,14-18,39H,10-13H2,1H3,(H,33,38)(H,34,37) HLMNVNWBDZVKRH-UHFFFAOYSA-N 226503 US9328096, 196 High affinity nerve growth factor receptor [441-796] Human 12 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226503 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226503&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962660 336293605 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396240 Clc1cc(Cl)c(cc1C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCc1nnc[nH]1)-c1ccccn1 InChI=1S/C25H18Cl2N8O2/c26-18-11-19(27)17(10-16(18)20-8-4-5-9-28-20)24(36)32-23-12-21(25(37)29-13-22-30-14-31-33-22)34-35(23)15-6-2-1-3-7-15/h1-12,14H,13H2,(H,29,37)(H,32,36)(H,30,31,33) XMGCFDGCDVWYDE-UHFFFAOYSA-N 226504 US9328096, 197 High affinity nerve growth factor receptor [441-796] Human 12.7 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226504 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226504&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962661 336293606 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396241 OCC1(CNC(=O)c2cc(NC(=O)c3cc(c(Cl)cc3Cl)-c3ccccn3)n(n2)-c2ccccc2)COC1 InChI=1S/C27H23Cl2N5O4/c28-20-11-21(29)19(10-18(20)22-8-4-5-9-30-22)25(36)32-24-12-23(33-34(24)17-6-2-1-3-7-17)26(37)31-13-27(14-35)15-38-16-27/h1-12,35H,13-16H2,(H,31,37)(H,32,36) UQLYYQWBABNRMG-UHFFFAOYSA-N 226505 US9328096, 198 High affinity nerve growth factor receptor [441-796] Human 10.9 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226505 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226505&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962662 336293607 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396242 C[C@@H](O)CNC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C25H21Cl2N5O3/c1-15(33)14-29-25(35)22-13-23(32(31-22)16-7-3-2-4-8-16)30-24(34)18-11-17(19(26)12-20(18)27)21-9-5-6-10-28-21/h2-13,15,33H,14H2,1H3,(H,29,35)(H,30,34)/t15-/m1/s1 IQOVSIHUPNSPGA-OAHLLOKOSA-N 226506 US9328096, 199 High affinity nerve growth factor receptor [441-796] Human 13 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226506 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226506&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962663 336293608 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396243 C[C@H](CO)NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C25H21Cl2N5O3/c1-15(14-33)29-25(35)22-13-23(32(31-22)16-7-3-2-4-8-16)30-24(34)18-11-17(19(26)12-20(18)27)21-9-5-6-10-28-21/h2-13,15,33H,14H2,1H3,(H,29,35)(H,30,34)/t15-/m1/s1 IQHHAPKSJWCKBQ-OAHLLOKOSA-N 226507 US9328096, 200 High affinity nerve growth factor receptor [441-796] Human 13.4 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226507 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226507&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962664 336293609 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396244 O[C@H]1CC[C@@H](CC1)NC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C28H24ClF2N5O3/c29-21-14-23(31)20(26-22(30)7-4-12-32-26)13-19(21)27(38)34-25-15-24(35-36(25)17-5-2-1-3-6-17)28(39)33-16-8-10-18(37)11-9-16/h1-7,12-16,18,37H,8-11H2,(H,33,39)(H,34,38)/t16-,18- WDHUBNPJVCIQEU-SAABIXHNSA-N 226508 US9328096, 201 High affinity nerve growth factor receptor [441-796] Human 12 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226508 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226508&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962665 336293610 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396245 C[C@@H](O)CNC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C25H20ClF2N5O3/c1-14(34)13-30-25(36)21-12-22(33(32-21)15-6-3-2-4-7-15)31-24(35)16-10-17(20(28)11-18(16)26)23-19(27)8-5-9-29-23/h2-12,14,34H,13H2,1H3,(H,30,36)(H,31,35)/t14-/m1/s1 XWBPKJRHDXVFDJ-CQSZACIVSA-N 226509 US9328096, 202 High affinity nerve growth factor receptor [441-796] Human 20.7 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226509 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226509&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962666 336293611 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396246 OC[C@H](O)CNC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C25H20ClF2N5O4/c26-18-10-20(28)17(23-19(27)7-4-8-29-23)9-16(18)24(36)31-22-11-21(25(37)30-12-15(35)13-34)32-33(22)14-5-2-1-3-6-14/h1-11,15,34-35H,12-13H2,(H,30,37)(H,31,36)/t15-/m1/s1 GIBWGKZKJVKQDY-OAHLLOKOSA-N 226510 US9328096, 203 High affinity nerve growth factor receptor [441-796] Human 25 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226510 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226510&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962667 336293612 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396247 Fc1cc(Cl)c(cc1-c1ncccc1F)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCc1ccon1 InChI=1S/C26H17ClF2N6O3/c27-19-12-21(29)18(24-20(28)7-4-9-30-24)11-17(19)25(36)32-23-13-22(26(37)31-14-15-8-10-38-34-15)33-35(23)16-5-2-1-3-6-16/h1-13H,14H2,(H,31,37)(H,32,36) KWURRFSVIDPSHE-UHFFFAOYSA-N 226511 US9328096, 204 High affinity nerve growth factor receptor [441-796] Human 15 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226511 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226511&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962668 336293613 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396248 Fc1cc(Cl)c(cc1-c1ncccc1F)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCc1ccn[nH]1 InChI=1S/C26H18ClF2N7O2/c27-19-12-21(29)18(24-20(28)7-4-9-30-24)11-17(19)25(37)33-23-13-22(26(38)31-14-15-8-10-32-34-15)35-36(23)16-5-2-1-3-6-16/h1-13H,14H2,(H,31,38)(H,32,34)(H,33,37) IOOABILCRPJBIR-UHFFFAOYSA-N 226512 US9328096, 205 High affinity nerve growth factor receptor [441-796] Human 11 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226512 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226512&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962669 336293614 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396249 OC[C@@H](O)CNC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C25H20ClF2N5O4/c26-18-10-20(28)17(23-19(27)7-4-8-29-23)9-16(18)24(36)31-22-11-21(25(37)30-12-15(35)13-34)32-33(22)14-5-2-1-3-6-14/h1-11,15,34-35H,12-13H2,(H,30,37)(H,31,36)/t15-/m0/s1 GIBWGKZKJVKQDY-HNNXBMFYSA-N 226513 US9328096, 206 High affinity nerve growth factor receptor [441-796] Human 29.8 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226513 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226513&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962670 336293615 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396250 Nc1cccc(CNC(=O)c2cc(NC(=O)c3cc(c(F)cc3Cl)-c3ncccc3F)n(n2)-c2ccccc2)n1 InChI=1S/C28H20ClF2N7O2/c29-20-13-22(31)19(26-21(30)9-5-11-33-26)12-18(20)27(39)36-25-14-23(37-38(25)17-7-2-1-3-8-17)28(40)34-15-16-6-4-10-24(32)35-16/h1-14H,15H2,(H2,32,35)(H,34,40)(H,36,39) OPIGBECEBBVHNN-UHFFFAOYSA-N 226514 US9328096, 207 High affinity nerve growth factor receptor [441-796] Human 2.06 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226514 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226514&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962671 336293616 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396251 Nc1ncccc1CNC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C28H20ClF2N7O2/c29-20-13-22(31)19(25-21(30)9-5-10-33-25)12-18(20)27(39)36-24-14-23(37-38(24)17-7-2-1-3-8-17)28(40)35-15-16-6-4-11-34-26(16)32/h1-14H,15H2,(H2,32,34)(H,35,40)(H,36,39) ZWJHGQJUWHXEQA-UHFFFAOYSA-N 226515 US9328096, 208 High affinity nerve growth factor receptor [441-796] Human 5.55 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226515 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226515&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962672 336293617 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396252 Nc1[nH]ncc1CNC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C26H20ClFN8O2/c27-19-9-8-15(23-20(28)7-4-10-30-23)11-18(19)25(37)33-22-12-21(35-36(22)17-5-2-1-3-6-17)26(38)31-13-16-14-32-34-24(16)29/h1-12,14H,13H2,(H,31,38)(H,33,37)(H3,29,32,34) WLYGPSITEQZWBE-UHFFFAOYSA-N 226516 US9328096, 209 High affinity nerve growth factor receptor [441-796] Human 48.2 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226516 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226516&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962673 336293618 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396253 Cn1nc(N)cc1CNC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C27H22ClFN8O2/c1-36-18(13-23(30)35-36)15-32-27(39)22-14-24(37(34-22)17-6-3-2-4-7-17)33-26(38)19-12-16(9-10-20(19)28)25-21(29)8-5-11-31-25/h2-14H,15H2,1H3,(H2,30,35)(H,32,39)(H,33,38) NRZTXVSGXLWWTD-UHFFFAOYSA-N 226517 US9328096, 210 High affinity nerve growth factor receptor [441-796] Human 37.9 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226517 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226517&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962674 336293619 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396254 Fc1cc(Cl)c(cc1-c1ccccn1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCc1ccn[nH]1 InChI=1S/C26H19ClFN7O2/c27-20-13-21(28)19(22-8-4-5-10-29-22)12-18(20)25(36)32-24-14-23(26(37)30-15-16-9-11-31-33-16)34-35(24)17-6-2-1-3-7-17/h1-14H,15H2,(H,30,37)(H,31,33)(H,32,36) DVEBMLPGFNDJGZ-UHFFFAOYSA-N 226518 US9328096, 211 High affinity nerve growth factor receptor [441-796] Human 14.2 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226518 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226518&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962675 336293620 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396255 Nc1cc(CNC(=O)c2cc(NC(=O)c3cc(c(Cl)cc3Cl)-c3ccccn3)n(n2)-c2ccccc2)n[nH]1 InChI=1S/C26H20Cl2N8O2/c27-19-12-20(28)18(11-17(19)21-8-4-5-9-30-21)25(37)32-24-13-22(35-36(24)16-6-2-1-3-7-16)26(38)31-14-15-10-23(29)34-33-15/h1-13H,14H2,(H,31,38)(H,32,37)(H3,29,33,34) BMHUJIIYUFKBSY-UHFFFAOYSA-N 226519 US9328096, 212 High affinity nerve growth factor receptor [441-796] Human 20.7 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226519 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226519&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962676 336293621 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396256 CC1(O)CCC(CC1)NC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C29H26ClF2N5O3/c1-29(40)11-9-17(10-12-29)34-28(39)24-16-25(37(36-24)18-6-3-2-4-7-18)35-27(38)19-14-20(23(32)15-21(19)30)26-22(31)8-5-13-33-26/h2-8,13-17,40H,9-12H2,1H3,(H,34,39)(H,35,38) OOZKYAXDWBDJDD-UHFFFAOYSA-N 226520 US9328096, 213 High affinity nerve growth factor receptor [441-796] Human 6.72 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226520 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226520&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962677 336293622 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396257 Fc1cc(Cl)c(cc1-c1ncccc1F)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCc1cnn[nH]1 InChI=1S/C25H17ClF2N8O2/c26-18-10-20(28)17(23-19(27)7-4-8-29-23)9-16(18)24(37)32-22-11-21(25(38)30-12-14-13-31-35-33-14)34-36(22)15-5-2-1-3-6-15/h1-11,13H,12H2,(H,30,38)(H,32,37)(H,31,33,35) MCWNPNZAIBSNTR-UHFFFAOYSA-N 226521 US9328096, 214 High affinity nerve growth factor receptor [441-796] Human 3.63 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226521 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226521&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962678 336293623 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396258 OCCNC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C24H18ClF2N5O3/c25-17-12-19(27)16(22-18(26)7-4-8-28-22)11-15(17)23(34)30-21-13-20(24(35)29-9-10-33)31-32(21)14-5-2-1-3-6-14/h1-8,11-13,33H,9-10H2,(H,29,35)(H,30,34) JTWMNWYKLMZOMK-UHFFFAOYSA-N 226522 US9328096, 215 High affinity nerve growth factor receptor [441-796] Human 13 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226522 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226522&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962679 336293624 C04080 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396259 OCCCNC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C25H20ClF2N5O3/c26-18-13-20(28)17(23-19(27)8-4-9-29-23)12-16(18)24(35)31-22-14-21(25(36)30-10-5-11-34)32-33(22)15-6-2-1-3-7-15/h1-4,6-9,12-14,34H,5,10-11H2,(H,30,36)(H,31,35) ORFLXCUWWUVKTJ-UHFFFAOYSA-N 226523 US9328096, 216 High affinity nerve growth factor receptor [441-796] Human 7.21 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226523 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226523&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962680 336293625 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396260 Cc1[nH]nnc1CNC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C26H20ClFN8O2/c1-15-22(33-35-32-15)14-30-26(38)21-13-23(36(34-21)17-6-3-2-4-7-17)31-25(37)18-12-16(9-10-19(18)27)24-20(28)8-5-11-29-24/h2-13H,14H2,1H3,(H,30,38)(H,31,37)(H,32,33,35) SPGGHCLLSRTKSX-UHFFFAOYSA-N 226524 US9328096, 217 High affinity nerve growth factor receptor [441-796] Human 54.1 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226524 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226524&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962681 336293626 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396261 Nc1c[nH]nc1CNC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C26H20Cl2N8O2/c27-18-11-19(28)17(10-16(18)21-8-4-5-9-30-21)25(37)33-24-12-22(35-36(24)15-6-2-1-3-7-15)26(38)31-14-23-20(29)13-32-34-23/h1-13H,14,29H2,(H,31,38)(H,32,34)(H,33,37) CTZFKYLHPUYJOZ-UHFFFAOYSA-N 226525 US9328096, 218 High affinity nerve growth factor receptor [441-796] Human 82 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226525 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226525&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962682 336293627 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396262 Clc1cc(Cl)c(cc1C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCc1cccnn1)-c1ccccn1 InChI=1S/C27H19Cl2N7O2/c28-21-14-22(29)20(13-19(21)23-10-4-5-11-30-23)26(37)33-25-15-24(35-36(25)18-8-2-1-3-9-18)27(38)31-16-17-7-6-12-32-34-17/h1-15H,16H2,(H,31,38)(H,33,37) MGMAXAJZKDAAOM-UHFFFAOYSA-N 226526 US9328096, 219 High affinity nerve growth factor receptor [441-796] Human 7.35 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226526 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226526&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962683 336293628 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396263 Cc1n[nH]c(C)c1NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C27H21Cl2N7O2/c1-15-25(16(2)34-33-15)32-27(38)23-14-24(36(35-23)17-8-4-3-5-9-17)31-26(37)19-12-18(20(28)13-21(19)29)22-10-6-7-11-30-22/h3-14H,1-2H3,(H,31,37)(H,32,38)(H,33,34) BVWGMIMXCDLZGU-UHFFFAOYSA-N 226527 US9328096, 220 High affinity nerve growth factor receptor [441-796] Human 1.71 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226527 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226527&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962684 336293629 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396264 N[C@H]1C[C@@H](C1)NC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C26H22ClFN6O2/c27-20-13-21(28)19(22-8-4-5-9-30-22)12-18(20)25(35)32-24-14-23(26(36)31-16-10-15(29)11-16)33-34(24)17-6-2-1-3-7-17/h1-9,12-16H,10-11,29H2,(H,31,36)(H,32,35)/t15-,16- RMQGHRVQIJLFRR-WKILWMFISA-N 226528 US9328096, 221 High affinity nerve growth factor receptor [441-796] Human 126 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226528 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226528&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962685 336293630 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396265 Nc1cc(CNC(=O)c2cc(NC(=O)c3cc(ccc3Cl)-c3ncccc3F)n(n2)-c2ccccc2)ccn1 InChI=1S/C28H21ClFN7O2/c29-21-9-8-18(26-22(30)7-4-11-33-26)14-20(21)27(38)35-25-15-23(36-37(25)19-5-2-1-3-6-19)28(39)34-16-17-10-12-32-24(31)13-17/h1-15H,16H2,(H2,31,32)(H,34,39)(H,35,38) BWFRHHSRQBDBJL-UHFFFAOYSA-N 226529 US9328096, 222 High affinity nerve growth factor receptor [441-796] Human 3.37 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226529 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226529&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962686 336293631 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396266 Fc1cccnc1-c1ccc(Cl)c(c1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCc1ccnnc1 InChI=1S/C27H19ClFN7O2/c28-21-9-8-18(25-22(29)7-4-11-30-25)13-20(21)26(37)34-24-14-23(35-36(24)19-5-2-1-3-6-19)27(38)31-15-17-10-12-32-33-16-17/h1-14,16H,15H2,(H,31,38)(H,34,37) LLYHNRBYKXEJCU-UHFFFAOYSA-N 226530 US9328096, 223 High affinity nerve growth factor receptor [441-796] Human 38 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226530 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226530&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962687 336293632 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396267 Nc1cccc(CNC(=O)c2cc(NC(=O)c3cc(ccc3Cl)-c3ncccc3F)n(n2)-c2ccccc2)n1 InChI=1S/C28H21ClFN7O2/c29-21-12-11-17(26-22(30)9-5-13-32-26)14-20(21)27(38)35-25-15-23(36-37(25)19-7-2-1-3-8-19)28(39)33-16-18-6-4-10-24(31)34-18/h1-15H,16H2,(H2,31,34)(H,33,39)(H,35,38) GTGNQYCQFPVKMN-UHFFFAOYSA-N 226531 US9328096, 224 High affinity nerve growth factor receptor [441-796] Human 9.42 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226531 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226531&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962688 336293633 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396268 Fc1cccnc1-c1ccc(Cl)c(c1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NC1COC1 InChI=1S/C25H19ClFN5O3/c26-19-9-8-15(23-20(27)7-4-10-28-23)11-18(19)24(33)30-22-12-21(25(34)29-16-13-35-14-16)31-32(22)17-5-2-1-3-6-17/h1-12,16H,13-14H2,(H,29,34)(H,30,33) XJXGOFQWHSDSBC-UHFFFAOYSA-N 226532 US9328096, 225 High affinity nerve growth factor receptor [441-796] Human 101 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226532 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226532&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962689 336293634 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396269 OCCCNC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C25H21ClFN5O3/c26-19-10-9-16(23-20(27)8-4-11-28-23)14-18(19)24(34)30-22-15-21(25(35)29-12-5-13-33)31-32(22)17-6-2-1-3-7-17/h1-4,6-11,14-15,33H,5,12-13H2,(H,29,35)(H,30,34) WIHRBMADIQSVNT-UHFFFAOYSA-N 226533 US9328096, 226 High affinity nerve growth factor receptor [441-796] Human 61.4 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226533&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962690 336293635 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396270 COCCNC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C25H21ClFN5O3/c1-35-13-12-29-25(34)21-15-22(32(31-21)17-6-3-2-4-7-17)30-24(33)18-14-16(9-10-19(18)26)23-20(27)8-5-11-28-23/h2-11,14-15H,12-13H2,1H3,(H,29,34)(H,30,33) SQMWTIPGTREWOF-UHFFFAOYSA-N 226534 US9328096, 227 High affinity nerve growth factor receptor [441-796] Human 75.8 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226534 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226534&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962691 336293636 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396271 OCC1(CC1)NC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C26H21ClFN5O3/c27-19-9-8-16(23-20(28)7-4-12-29-23)13-18(19)24(35)30-22-14-21(25(36)31-26(15-34)10-11-26)32-33(22)17-5-2-1-3-6-17/h1-9,12-14,34H,10-11,15H2,(H,30,35)(H,31,36) WXTAJMAKKCKPFG-UHFFFAOYSA-N 226535 US9328096, 228 High affinity nerve growth factor receptor [441-796] Human 58.1 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226535 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226535&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962692 336293637 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396272 O[C@H]1C[C@@H](C1)NC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C26H21ClFN5O3/c27-20-9-8-15(24-21(28)7-4-10-29-24)11-19(20)25(35)31-23-14-22(26(36)30-16-12-18(34)13-16)32-33(23)17-5-2-1-3-6-17/h1-11,14,16,18,34H,12-13H2,(H,30,36)(H,31,35)/t16-,18- AAIGYDQLJHQJLX-SAABIXHNSA-N 226536 US9328096, 229 High affinity nerve growth factor receptor [441-796] Human 61.8 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226536 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226536&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962693 336293638 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396273 Fc1cccnc1-c1ccc(Cl)c(c1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NC1CCOC1 InChI=1S/C26H21ClFN5O3/c27-20-9-8-16(24-21(28)7-4-11-29-24)13-19(20)25(34)31-23-14-22(26(35)30-17-10-12-36-15-17)32-33(23)18-5-2-1-3-6-18/h1-9,11,13-14,17H,10,12,15H2,(H,30,35)(H,31,34) NSXNLEGBYBECIY-UHFFFAOYSA-N 226537 US9328096, 230 High affinity nerve growth factor receptor [441-796] Human 70.7 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226537 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226537&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962694 336293639 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396274 Fc1cccnc1-c1ccc(Cl)c(c1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCC1CCO1 InChI=1S/C26H21ClFN5O3/c27-20-9-8-16(24-21(28)7-4-11-29-24)13-19(20)25(34)31-23-14-22(26(35)30-15-18-10-12-36-18)32-33(23)17-5-2-1-3-6-17/h1-9,11,13-14,18H,10,12,15H2,(H,30,35)(H,31,34) LETBMLDBWWRAOY-UHFFFAOYSA-N 226538 US9328096, 231 High affinity nerve growth factor receptor [441-796] Human 95.4 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226538 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226538&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962695 336293640 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396275 OCC(CO)NC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C25H21ClFN5O4/c26-19-9-8-15(23-20(27)7-4-10-28-23)11-18(19)24(35)30-22-12-21(25(36)29-16(13-33)14-34)31-32(22)17-5-2-1-3-6-17/h1-12,16,33-34H,13-14H2,(H,29,36)(H,30,35) KICAGFWAPWXBMW-UHFFFAOYSA-N 226539 US9328096, 232 High affinity nerve growth factor receptor [441-796] Human 267 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226539 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226539&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962696 336293641 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396276 Fc1cccnc1-c1ccc(Cl)c(c1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NC1CCCOC1 InChI=1S/C27H23ClFN5O3/c28-21-11-10-17(25-22(29)9-4-12-30-25)14-20(21)26(35)32-24-15-23(27(36)31-18-6-5-13-37-16-18)33-34(24)19-7-2-1-3-8-19/h1-4,7-12,14-15,18H,5-6,13,16H2,(H,31,36)(H,32,35) JRFWEPPJHVWYHX-UHFFFAOYSA-N 226540 US9328096, 233 High affinity nerve growth factor receptor [441-796] Human 56.8 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226540 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226540&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962697 336293642 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396277 Fc1cccnc1-c1ccc(Cl)c(c1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCC1CCOC1 InChI=1S/C27H23ClFN5O3/c28-21-9-8-18(25-22(29)7-4-11-30-25)13-20(21)26(35)32-24-14-23(27(36)31-15-17-10-12-37-16-17)33-34(24)19-5-2-1-3-6-19/h1-9,11,13-14,17H,10,12,15-16H2,(H,31,36)(H,32,35) OATUOJOSDIXVJO-UHFFFAOYSA-N 226541 US9328096, 234 High affinity nerve growth factor receptor [441-796] Human 61 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226541 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226541&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962698 336293643 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396278 OC[C@H]1C[C@@H](C1)NC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C27H23ClFN5O3/c28-21-9-8-17(25-22(29)7-4-10-30-25)13-20(21)26(36)32-24-14-23(27(37)31-18-11-16(12-18)15-35)33-34(24)19-5-2-1-3-6-19/h1-10,13-14,16,18,35H,11-12,15H2,(H,31,37)(H,32,36)/t16-,18- LYHCNIHMFKXBQI-SAABIXHNSA-N 226542 US9328096, 235 High affinity nerve growth factor receptor [441-796] Human 67.6 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226542 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226542&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962699 336293644 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396279 OC1(CNC(=O)c2cc(NC(=O)c3cc(ccc3Cl)-c3ncccc3F)n(n2)-c2ccccc2)CCC1 InChI=1S/C27H23ClFN5O3/c28-20-10-9-17(24-21(29)8-4-13-30-24)14-19(20)25(35)32-23-15-22(26(36)31-16-27(37)11-5-12-27)33-34(23)18-6-2-1-3-7-18/h1-4,6-10,13-15,37H,5,11-12,16H2,(H,31,36)(H,32,35) WHLWPEHZKYWKCS-UHFFFAOYSA-N 226543 US9328096, 236 High affinity nerve growth factor receptor [441-796] Human 86.2 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226543 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226543&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962700 336293645 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396280 Fc1cccnc1-c1ccc(Cl)c(c1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NC1CCOCC1 InChI=1S/C27H23ClFN5O3/c28-21-9-8-17(25-22(29)7-4-12-30-25)15-20(21)26(35)32-24-16-23(27(36)31-18-10-13-37-14-11-18)33-34(24)19-5-2-1-3-6-19/h1-9,12,15-16,18H,10-11,13-14H2,(H,31,36)(H,32,35) RPLFNJLREVCXHU-UHFFFAOYSA-N 226544 US9328096, 237 High affinity nerve growth factor receptor [441-796] Human 102 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226544 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226544&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962701 336293646 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396281 Fc1cccnc1-c1ccc(Cl)c(c1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCC1CCCO1 InChI=1S/C27H23ClFN5O3/c28-21-11-10-17(25-22(29)9-4-12-30-25)14-20(21)26(35)32-24-15-23(27(36)31-16-19-8-5-13-37-19)33-34(24)18-6-2-1-3-7-18/h1-4,6-7,9-12,14-15,19H,5,8,13,16H2,(H,31,36)(H,32,35) PHFRHGMIEKDCQW-UHFFFAOYSA-N 226545 US9328096, 238 High affinity nerve growth factor receptor [441-796] Human 151 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226545 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226545&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962702 336293647 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396282 CC(C)(CCO)NC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C27H25ClFN5O3/c1-27(2,12-14-35)32-26(37)22-16-23(34(33-22)18-7-4-3-5-8-18)31-25(36)19-15-17(10-11-20(19)28)24-21(29)9-6-13-30-24/h3-11,13,15-16,35H,12,14H2,1-2H3,(H,31,36)(H,32,37) HNMHHBVIXOVQGG-UHFFFAOYSA-N 226546 US9328096, 239 High affinity nerve growth factor receptor [441-796] Human 55 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226546 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226546&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962703 336293648 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396283 Fc1cccnc1-c1ccc(Cl)c(c1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCC1(F)COC1 InChI=1S/C26H20ClF2N5O3/c27-19-9-8-16(23-20(28)7-4-10-30-23)11-18(19)24(35)32-22-12-21(25(36)31-13-26(29)14-37-15-26)33-34(22)17-5-2-1-3-6-17/h1-12H,13-15H2,(H,31,36)(H,32,35) CWFVVGCWYUXYNI-UHFFFAOYSA-N 226547 US9328096, 240 High affinity nerve growth factor receptor [441-796] Human 89.7 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226547 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226547&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962704 336293649 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396284 Cn1cncc1CNC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C27H21ClFN7O2/c1-35-16-30-14-19(35)15-32-27(38)23-13-24(36(34-23)18-6-3-2-4-7-18)33-26(37)20-12-17(9-10-21(20)28)25-22(29)8-5-11-31-25/h2-14,16H,15H2,1H3,(H,32,38)(H,33,37) AMWQZNYTYGXPKR-UHFFFAOYSA-N 226548 US9328096, 241 High affinity nerve growth factor receptor [441-796] Human 65.6 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226548 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226548&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962705 336293650 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396285 Cc1c[nH]c(CNC(=O)c2cc(NC(=O)c3cc(ccc3Cl)-c3ncccc3F)n(n2)-c2ccccc2)n1 InChI=1S/C27H21ClFN7O2/c1-16-14-31-23(33-16)15-32-27(38)22-13-24(36(35-22)18-6-3-2-4-7-18)34-26(37)19-12-17(9-10-20(19)28)25-21(29)8-5-11-30-25/h2-14H,15H2,1H3,(H,31,33)(H,32,38)(H,34,37) LXVYDOQLOSOOHX-UHFFFAOYSA-N 226549 US9328096, 242 High affinity nerve growth factor receptor [441-796] Human 163 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226549 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226549&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962706 336293651 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396286 Cn1cnc(CNC(=O)c2cc(NC(=O)c3cc(ccc3Cl)-c3ncccc3F)n(n2)-c2ccccc2)c1 InChI=1S/C27H21ClFN7O2/c1-35-15-18(32-16-35)14-31-27(38)23-13-24(36(34-23)19-6-3-2-4-7-19)33-26(37)20-12-17(9-10-21(20)28)25-22(29)8-5-11-30-25/h2-13,15-16H,14H2,1H3,(H,31,38)(H,33,37) URHMGSIZTZLVOL-UHFFFAOYSA-N 226550 US9328096, 243 High affinity nerve growth factor receptor [441-796] Human 290 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226550 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226550&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962707 336293652 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396287 Cn1ccnc1CNC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C27H21ClFN7O2/c1-35-13-12-30-24(35)16-32-27(38)22-15-23(36(34-22)18-6-3-2-4-7-18)33-26(37)19-14-17(9-10-20(19)28)25-21(29)8-5-11-31-25/h2-15H,16H2,1H3,(H,32,38)(H,33,37) LENKNYSYGWVEEN-UHFFFAOYSA-N 226551 US9328096, 244 High affinity nerve growth factor receptor [441-796] Human 374 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226551 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226551&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962708 336293653 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396288 Fc1cccnc1-c1ccc(Cl)c(c1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCCc1ncn[nH]1 InChI=1S/C26H20ClFN8O2/c27-19-9-8-16(24-20(28)7-4-11-29-24)13-18(19)25(37)33-23-14-21(35-36(23)17-5-2-1-3-6-17)26(38)30-12-10-22-31-15-32-34-22/h1-9,11,13-15H,10,12H2,(H,30,38)(H,33,37)(H,31,32,34) NTQMBKOVYBIDPJ-UHFFFAOYSA-N 226552 US9328096, 245 High affinity nerve growth factor receptor [441-796] Human 179 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226552 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226552&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962709 336293654 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396289 Cc1nonc1CNC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C26H19ClFN7O3/c1-15-22(34-38-33-15)14-30-26(37)21-13-23(35(32-21)17-6-3-2-4-7-17)31-25(36)18-12-16(9-10-19(18)27)24-20(28)8-5-11-29-24/h2-13H,14H2,1H3,(H,30,37)(H,31,36) YENDAOYPFIMFGA-UHFFFAOYSA-N 226553 US9328096, 246 High affinity nerve growth factor receptor [441-796] Human 86.2 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226553 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226553&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962710 336293655 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396290 Cc1nnc(CNC(=O)c2cc(NC(=O)c3cc(ccc3Cl)-c3ncccc3F)n(n2)-c2ccccc2)o1 InChI=1S/C26H19ClFN7O3/c1-15-32-33-23(38-15)14-30-26(37)21-13-22(35(34-21)17-6-3-2-4-7-17)31-25(36)18-12-16(9-10-19(18)27)24-20(28)8-5-11-29-24/h2-13H,14H2,1H3,(H,30,37)(H,31,36) HWIDCJLWALYJTG-UHFFFAOYSA-N 226554 US9328096, 247 High affinity nerve growth factor receptor [441-796] Human 99.4 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226554 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226554&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962711 336293656 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396291 O[C@H]1CCCC[C@@H]1NC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C28H25ClFN5O3/c29-20-13-12-17(26-21(30)9-6-14-31-26)15-19(20)27(37)33-25-16-23(34-35(25)18-7-2-1-3-8-18)28(38)32-22-10-4-5-11-24(22)36/h1-3,6-9,12-16,22,24,36H,4-5,10-11H2,(H,32,38)(H,33,37)/t22-,24-/m0/s1 ATTMTXSZDLFPGF-UPVQGACJSA-N 226555 US9328096, 248 High affinity nerve growth factor receptor [441-796] Human 67.4 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226555 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226555&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962712 336293657 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396292 O[C@@H]1CCCC[C@@H]1NC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C28H25ClFN5O3/c29-20-13-12-17(26-21(30)9-6-14-31-26)15-19(20)27(37)33-25-16-23(34-35(25)18-7-2-1-3-8-18)28(38)32-22-10-4-5-11-24(22)36/h1-3,6-9,12-16,22,24,36H,4-5,10-11H2,(H,32,38)(H,33,37)/t22-,24+/m0/s1 ATTMTXSZDLFPGF-LADGPHEKSA-N 226556 US9328096, 249 High affinity nerve growth factor receptor [441-796] Human 107 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226556 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226556&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962713 336293658 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396293 OCCC1(COC1)NC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C27H23ClFN5O4/c28-20-9-8-17(24-21(29)7-4-11-30-24)13-19(20)25(36)31-23-14-22(33-34(23)18-5-2-1-3-6-18)26(37)32-27(10-12-35)15-38-16-27/h1-9,11,13-14,35H,10,12,15-16H2,(H,31,36)(H,32,37) KFGZZBLZBLIDGA-UHFFFAOYSA-N 226557 US9328096, 250 High affinity nerve growth factor receptor [441-796] Human 113 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226557 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226557&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962714 336293659 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396294 O[C@H]1COCC[C@@H]1NC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C27H23ClFN5O4/c28-19-9-8-16(25-20(29)7-4-11-30-25)13-18(19)26(36)32-24-14-22(33-34(24)17-5-2-1-3-6-17)27(37)31-21-10-12-38-15-23(21)35/h1-9,11,13-14,21,23,35H,10,12,15H2,(H,31,37)(H,32,36)/t21-,23-/m0/s1 QQFXTUYHDKKFOW-GMAHTHKFSA-N 226558 US9328096, 251 High affinity nerve growth factor receptor [441-796] Human 115 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226558 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226558&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962715 336293660 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396295 CC1(O)CCC(CC1)NC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C29H27ClFN5O3/c1-29(39)13-11-19(12-14-29)33-28(38)24-17-25(36(35-24)20-6-3-2-4-7-20)34-27(37)21-16-18(9-10-22(21)30)26-23(31)8-5-15-32-26/h2-10,15-17,19,39H,11-14H2,1H3,(H,33,38)(H,34,37) NOWGUHDCKFZYIZ-UHFFFAOYSA-N 226559 US9328096, 252 High affinity nerve growth factor receptor [441-796] Human 39.8 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226559 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226559&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962716 336293661 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396296 CN1CCOC(CNC(=O)c2cc(NC(=O)c3cc(ccc3Cl)-c3ncccc3F)n(n2)-c2ccccc2)C1 InChI=1S/C28H26ClFN6O3/c1-35-12-13-39-20(17-35)16-32-28(38)24-15-25(36(34-24)19-6-3-2-4-7-19)33-27(37)21-14-18(9-10-22(21)29)26-23(30)8-5-11-31-26/h2-11,14-15,20H,12-13,16-17H2,1H3,(H,32,38)(H,33,37) QCRFGYQOCFYRPF-UHFFFAOYSA-N 226560 US9328096, 253 High affinity nerve growth factor receptor [441-796] Human 199 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226560 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226560&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962717 336293662 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396297 OC1(CNC(=O)c2cc(NC(=O)c3cc(ccc3Cl)-c3ncccc3F)n(n2)-c2ccccc2)CCOCC1 InChI=1S/C28H25ClFN5O4/c29-21-9-8-18(25-22(30)7-4-12-31-25)15-20(21)26(36)33-24-16-23(34-35(24)19-5-2-1-3-6-19)27(37)32-17-28(38)10-13-39-14-11-28/h1-9,12,15-16,38H,10-11,13-14,17H2,(H,32,37)(H,33,36) QGMCDFRZHQDSQV-UHFFFAOYSA-N 226561 US9328096, 254 High affinity nerve growth factor receptor [441-796] Human 171 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226561 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226561&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962718 336293663 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396298 CC1(C)C(O)C(C)(C)C1NC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C30H29ClFN5O3/c1-29(2)27(30(3,4)28(29)40)35-26(39)22-16-23(37(36-22)18-9-6-5-7-10-18)34-25(38)19-15-17(12-13-20(19)31)24-21(32)11-8-14-33-24/h5-16,27-28,40H,1-4H3,(H,34,38)(H,35,39) WSTQJHJMOFJSIU-UHFFFAOYSA-N 226562 US9328096, 255::US9328096, 256 High affinity nerve growth factor receptor [441-796] Human 182 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226562 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226562&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962719 336293664 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396299 CC1(C)C(O)C(C)(C)C1NC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C30H29ClFN5O3/c1-29(2)27(30(3,4)28(29)40)35-26(39)22-16-23(37(36-22)18-9-6-5-7-10-18)34-25(38)19-15-17(12-13-20(19)31)24-21(32)11-8-14-33-24/h5-16,27-28,40H,1-4H3,(H,34,38)(H,35,39) WSTQJHJMOFJSIU-UHFFFAOYSA-N 226562 US9328096, 255::US9328096, 256 High affinity nerve growth factor receptor [441-796] Human 8130 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226562 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226562&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962719 336293664 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396300 CN1CC(CNC(=O)c2cc(NC(=O)c3cc(ccc3Cl)-c3ncccc3F)n(n2)-c2ccccc2)OCC1=O InChI=1S/C28H24ClFN6O4/c1-35-15-19(40-16-25(35)37)14-32-28(39)23-13-24(36(34-23)18-6-3-2-4-7-18)33-27(38)20-12-17(9-10-21(20)29)26-22(30)8-5-11-31-26/h2-13,19H,14-16H2,1H3,(H,32,39)(H,33,38) YFRQHEORMFNIRP-UHFFFAOYSA-N 226564 US9328096, 257 High affinity nerve growth factor receptor [441-796] Human 213 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226564 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226564&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962720 336293665 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396301 CN1CCC(O)(CNC(=O)c2cc(NC(=O)c3cc(ccc3Cl)-c3ncccc3F)n(n2)-c2ccccc2)CC1 InChI=1S/C29H28ClFN6O3/c1-36-14-11-29(40,12-15-36)18-33-28(39)24-17-25(37(35-24)20-6-3-2-4-7-20)34-27(38)21-16-19(9-10-22(21)30)26-23(31)8-5-13-32-26/h2-10,13,16-17,40H,11-12,14-15,18H2,1H3,(H,33,39)(H,34,38) ZTUKBDAXUWKHNT-UHFFFAOYSA-N 226565 US9328096, 258 High affinity nerve growth factor receptor [441-796] Human 803 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226565 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226565&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962721 336293666 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396302 Fc1cccnc1-c1ccc(Cl)c(c1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NC1CCS(=O)(=O)CC1 InChI=1S/C27H23ClFN5O4S/c28-21-9-8-17(25-22(29)7-4-12-30-25)15-20(21)26(35)32-24-16-23(33-34(24)19-5-2-1-3-6-19)27(36)31-18-10-13-39(37,38)14-11-18/h1-9,12,15-16,18H,10-11,13-14H2,(H,31,36)(H,32,35) ZLLVNQAQYLOCOG-UHFFFAOYSA-N 226566 US9328096, 259 High affinity nerve growth factor receptor [441-796] Human 236 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226566 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226566&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962722 336293667 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396303 OCCN1CCC(CNC(=O)c2cc(NC(=O)c3cc(ccc3Cl)-c3ncccc3F)n(n2)-c2ccccc2)CC1 InChI=1S/C30H30ClFN6O3/c31-24-9-8-21(28-25(32)7-4-12-33-28)17-23(24)29(40)35-27-18-26(36-38(27)22-5-2-1-3-6-22)30(41)34-19-20-10-13-37(14-11-20)15-16-39/h1-9,12,17-18,20,39H,10-11,13-16,19H2,(H,34,41)(H,35,40) YINXJIZJCBLFGW-UHFFFAOYSA-N 226567 US9328096, 260 High affinity nerve growth factor receptor [441-796] Human 541 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226567 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226567&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962723 336293668 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396304 CNC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C23H17ClFN5O2/c1-26-23(32)20-13-21(30(29-20)14-7-3-2-4-8-14)28-22(31)15-11-16(18(25)12-17(15)24)19-9-5-6-10-27-19/h2-13H,1H3,(H,26,32)(H,28,31) DRKXEGVIUATCFZ-UHFFFAOYSA-N 226568 US9328096, 261 High affinity nerve growth factor receptor [441-796] Human 18.2 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226568 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226568&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962724 336293669 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396305 Fc1cc(Cl)c(cc1-c1ccccn1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NC1CC1 InChI=1S/C25H19ClFN5O2/c26-19-13-20(27)18(21-8-4-5-11-28-21)12-17(19)24(33)30-23-14-22(25(34)29-15-9-10-15)31-32(23)16-6-2-1-3-7-16/h1-8,11-15H,9-10H2,(H,29,34)(H,30,33) SZZSVYYEWVDKMP-UHFFFAOYSA-N 226569 US9328096, 262 High affinity nerve growth factor receptor [441-796] Human 19.8 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226569 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226569&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962725 336293670 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396306 Fc1cc(Cl)c(cc1-c1ccccn1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NC1COC1 InChI=1S/C25H19ClFN5O3/c26-19-11-20(27)18(21-8-4-5-9-28-21)10-17(19)24(33)30-23-12-22(25(34)29-15-13-35-14-15)31-32(23)16-6-2-1-3-7-16/h1-12,15H,13-14H2,(H,29,34)(H,30,33) GXWRRDGJBAVPTI-UHFFFAOYSA-N 226570 US9328096, 263 High affinity nerve growth factor receptor [441-796] Human 43.9 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226570 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226570&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962726 336293671 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396307 NC(=O)CNC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C24H18ClFN6O3/c25-17-11-18(26)16(19-8-4-5-9-28-19)10-15(17)23(34)30-22-12-20(24(35)29-13-21(27)33)31-32(22)14-6-2-1-3-7-14/h1-12H,13H2,(H2,27,33)(H,29,35)(H,30,34) KVFCWNMEPIWZBM-UHFFFAOYSA-N 226571 US9328096, 264 High affinity nerve growth factor receptor [441-796] Human 44.3 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226571 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226571&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962727 336293672 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396308 OCCCNC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C25H21ClFN5O3/c26-19-14-20(27)18(21-9-4-5-10-28-21)13-17(19)24(34)30-23-15-22(25(35)29-11-6-12-33)31-32(23)16-7-2-1-3-8-16/h1-5,7-10,13-15,33H,6,11-12H2,(H,29,35)(H,30,34) SEIXNJIIMGBISE-UHFFFAOYSA-N 226572 US9328096, 265 High affinity nerve growth factor receptor [441-796] Human 28.4 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226572 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226572&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962728 336293673 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396309 C[C@H](O)CNC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C25H21ClFN5O3/c1-15(33)14-29-25(35)22-13-23(32(31-22)16-7-3-2-4-8-16)30-24(34)17-11-18(20(27)12-19(17)26)21-9-5-6-10-28-21/h2-13,15,33H,14H2,1H3,(H,29,35)(H,30,34)/t15-/m0/s1 SQNFLDXAPWEPLO-HNNXBMFYSA-N 226573 US9328096, 266 High affinity nerve growth factor receptor [441-796] Human 30.8 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226573 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226573&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962729 336293674 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396310 CN1CC(C1)NC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C26H22ClFN6O2/c1-33-14-16(15-33)30-26(36)23-13-24(34(32-23)17-7-3-2-4-8-17)31-25(35)18-11-19(21(28)12-20(18)27)22-9-5-6-10-29-22/h2-13,16H,14-15H2,1H3,(H,30,36)(H,31,35) QYECVVDAILSFJX-UHFFFAOYSA-N 226574 US9328096, 267 High affinity nerve growth factor receptor [441-796] Human 86.6 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226574 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226574&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962730 336293675 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396311 Fc1cc(Cl)c(cc1-c1ccccn1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)N[C@@H]1CCOC1 InChI=1S/C26H21ClFN5O3/c27-20-13-21(28)19(22-8-4-5-10-29-22)12-18(20)25(34)31-24-14-23(26(35)30-16-9-11-36-15-16)32-33(24)17-6-2-1-3-7-17/h1-8,10,12-14,16H,9,11,15H2,(H,30,35)(H,31,34)/t16-/m1/s1 YNSWQTFNCJOXNC-MRXNPFEDSA-N 226575 US9328096, 268 High affinity nerve growth factor receptor [441-796] Human 26 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226575 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226575&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962731 336293676 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396312 Fc1cc(Cl)c(cc1-c1ccccn1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)N[C@H]1CCOC1 InChI=1S/C26H21ClFN5O3/c27-20-13-21(28)19(22-8-4-5-10-29-22)12-18(20)25(34)31-24-14-23(26(35)30-16-9-11-36-15-16)32-33(24)17-6-2-1-3-7-17/h1-8,10,12-14,16H,9,11,15H2,(H,30,35)(H,31,34)/t16-/m0/s1 YNSWQTFNCJOXNC-INIZCTEOSA-N 226576 US9328096, 269 High affinity nerve growth factor receptor [441-796] Human 41.7 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226576 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226576&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962732 336293677 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396313 CNC(=O)CNC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C25H20ClFN6O3/c1-28-23(34)14-30-25(36)21-13-22(33(32-21)15-7-3-2-4-8-15)31-24(35)16-11-17(19(27)12-18(16)26)20-9-5-6-10-29-20/h2-13H,14H2,1H3,(H,28,34)(H,30,36)(H,31,35) WXBWMPRWSXPKFA-UHFFFAOYSA-N 226577 US9328096, 270 High affinity nerve growth factor receptor [441-796] Human 69.8 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226577 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226577&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962733 336293678 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396314 CC(CO)CNC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C26H23ClFN5O3/c1-16(15-34)14-30-26(36)23-13-24(33(32-23)17-7-3-2-4-8-17)31-25(35)18-11-19(21(28)12-20(18)27)22-9-5-6-10-29-22/h2-13,16,34H,14-15H2,1H3,(H,30,36)(H,31,35) MIWKPBPZVRFNDB-UHFFFAOYSA-N 226578 US9328096, 271 High affinity nerve growth factor receptor [441-796] Human 19.8 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226578 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226578&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962734 336293679 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396315 CC(C)(O)CNC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C26H23ClFN5O3/c1-26(2,36)15-30-25(35)22-14-23(33(32-22)16-8-4-3-5-9-16)31-24(34)17-12-18(20(28)13-19(17)27)21-10-6-7-11-29-21/h3-14,36H,15H2,1-2H3,(H,30,35)(H,31,34) NOHJBGOHIDBCIG-UHFFFAOYSA-N 226579 US9328096, 272 High affinity nerve growth factor receptor [441-796] Human 35 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226579&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962735 336293680 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396316 OC[C@@H](O)CNC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C25H21ClFN5O4/c26-19-11-20(27)18(21-8-4-5-9-28-21)10-17(19)24(35)30-23-12-22(25(36)29-13-16(34)14-33)31-32(23)15-6-2-1-3-7-15/h1-12,16,33-34H,13-14H2,(H,29,36)(H,30,35)/t16-/m0/s1 HAIJTONPYJOFIJ-INIZCTEOSA-N 226580 US9328096, 273 High affinity nerve growth factor receptor [441-796] Human 68 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226580 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226580&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962736 336293681 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396317 Fc1cc(Cl)c(cc1-c1ccccn1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCc1cnc[nH]1 InChI=1S/C26H19ClFN7O2/c27-20-11-21(28)19(22-8-4-5-9-30-22)10-18(20)25(36)33-24-12-23(26(37)31-14-16-13-29-15-32-16)34-35(24)17-6-2-1-3-7-17/h1-13,15H,14H2,(H,29,32)(H,31,37)(H,33,36) CSEQJRQORPRXCZ-UHFFFAOYSA-N 226581 US9328096, 274 High affinity nerve growth factor receptor [441-796] Human 14.2 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226581 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226581&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962737 336293682 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396318 Fc1cc(Cl)c(cc1-c1ccccn1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCc1cocn1 InChI=1S/C26H18ClFN6O3/c27-20-11-21(28)19(22-8-4-5-9-29-22)10-18(20)25(35)32-24-12-23(26(36)30-13-16-14-37-15-31-16)33-34(24)17-6-2-1-3-7-17/h1-12,14-15H,13H2,(H,30,36)(H,32,35) VSWNLYFBRTUOBK-UHFFFAOYSA-N 226582 US9328096, 275 High affinity nerve growth factor receptor [441-796] Human 18.2 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226582 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226582&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962738 336293683 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396319 Fc1cc(Cl)c(cc1-c1ccccn1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCc1ccon1 InChI=1S/C26H18ClFN6O3/c27-20-13-21(28)19(22-8-4-5-10-29-22)12-18(20)25(35)31-24-14-23(26(36)30-15-16-9-11-37-33-16)32-34(24)17-6-2-1-3-7-17/h1-14H,15H2,(H,30,36)(H,31,35) IUZBCAFYSUGNCW-UHFFFAOYSA-N 226583 US9328096, 276 High affinity nerve growth factor receptor [441-796] Human 22.4 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226583 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226583&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962739 336293684 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396320 O[C@H]1C[C@H](C1)NC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C26H21ClFN5O3/c27-20-13-21(28)19(22-8-4-5-9-29-22)12-18(20)25(35)31-24-14-23(26(36)30-15-10-17(34)11-15)32-33(24)16-6-2-1-3-7-16/h1-9,12-15,17,34H,10-11H2,(H,30,36)(H,31,35)/t15-,17+ YXHXDNMUMRMXLB-WOVMCDHWSA-N 226584 US9328096, 277 High affinity nerve growth factor receptor [441-796] Human 25.9 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226584 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226584&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962740 336293685 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396321 Fc1cc(Cl)c(cc1-c1ccccn1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCc1ncco1 InChI=1S/C26H18ClFN6O3/c27-19-13-20(28)18(21-8-4-5-9-29-21)12-17(19)25(35)32-23-14-22(26(36)31-15-24-30-10-11-37-24)33-34(23)16-6-2-1-3-7-16/h1-14H,15H2,(H,31,36)(H,32,35) NQFXJRHONOBXIF-UHFFFAOYSA-N 226585 US9328096, 278 High affinity nerve growth factor receptor [441-796] Human 92.5 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226585 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226585&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962741 336293686 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396322 Fc1cc(Cl)c(cc1-c1ccccn1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCc1nnc[nH]1 InChI=1S/C25H18ClFN8O2/c26-18-11-19(27)17(20-8-4-5-9-28-20)10-16(18)24(36)32-23-12-21(25(37)29-13-22-30-14-31-33-22)34-35(23)15-6-2-1-3-7-15/h1-12,14H,13H2,(H,29,37)(H,32,36)(H,30,31,33) BSIBQGBNIHHMAT-UHFFFAOYSA-N 226586 US9328096, 279 High affinity nerve growth factor receptor [441-796] Human 47.7 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226586 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226586&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962742 336293687 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396323 CN1CCC(C1)NC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C27H24ClFN6O2/c1-34-12-10-17(16-34)31-27(37)24-15-25(35(33-24)18-7-3-2-4-8-18)32-26(36)19-13-20(22(29)14-21(19)28)23-9-5-6-11-30-23/h2-9,11,13-15,17H,10,12,16H2,1H3,(H,31,37)(H,32,36) VWCMNVGZFUYBMW-UHFFFAOYSA-N 226587 US9328096, 280 High affinity nerve growth factor receptor [441-796] Human 76.1 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226587 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226587&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962743 336293688 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396324 O[C@@H]1CC[C@@H](C1)NC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C27H23ClFN5O3/c28-21-14-22(29)20(23-8-4-5-11-30-23)13-19(21)26(36)32-25-15-24(27(37)31-16-9-10-18(35)12-16)33-34(25)17-6-2-1-3-7-17/h1-8,11,13-16,18,35H,9-10,12H2,(H,31,37)(H,32,36)/t16-,18+/m0/s1 WQWCGLTZKAURDF-FUHWJXTLSA-N 226588 US9328096, 281 High affinity nerve growth factor receptor [441-796] Human 22.4 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226588 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226588&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962744 336293689 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396325 Fc1cc(Cl)c(cc1-c1ccccn1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCC1CCOC1 InChI=1S/C27H23ClFN5O3/c28-21-13-22(29)20(23-8-4-5-10-30-23)12-19(21)26(35)32-25-14-24(27(36)31-15-17-9-11-37-16-17)33-34(25)18-6-2-1-3-7-18/h1-8,10,12-14,17H,9,11,15-16H2,(H,31,36)(H,32,35) OSVCCANXZQNTEN-UHFFFAOYSA-N 226589 US9328096, 282 High affinity nerve growth factor receptor [441-796] Human 24.4 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226589 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226589&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962745 336293690 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396326 OC[C@H]1C[C@H](C1)NC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C27H23ClFN5O3/c28-21-13-22(29)20(23-8-4-5-9-30-23)12-19(21)26(36)32-25-14-24(27(37)31-17-10-16(11-17)15-35)33-34(25)18-6-2-1-3-7-18/h1-9,12-14,16-17,35H,10-11,15H2,(H,31,37)(H,32,36)/t16-,17+ UEKDMVQYGWQUMF-CALCHBBNSA-N 226590 US9328096, 283 High affinity nerve growth factor receptor [441-796] Human 25.9 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226590 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226590&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962746 336293691 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396327 OC[C@H]1C[C@@H](C1)NC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C27H23ClFN5O3/c28-21-13-22(29)20(23-8-4-5-9-30-23)12-19(21)26(36)32-25-14-24(27(37)31-17-10-16(11-17)15-35)33-34(25)18-6-2-1-3-7-18/h1-9,12-14,16-17,35H,10-11,15H2,(H,31,37)(H,32,36)/t16-,17- UEKDMVQYGWQUMF-QAQDUYKDSA-N 226591 US9328096, 284 High affinity nerve growth factor receptor [441-796] Human 26.3 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226591 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226591&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962746 336293692 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396328 O[C@H]1C[C@@H](C1)NC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C26H21ClFN5O3/c27-20-13-21(28)19(22-8-4-5-9-29-22)12-18(20)25(35)31-24-14-23(26(36)30-15-10-17(34)11-15)32-33(24)16-6-2-1-3-7-16/h1-9,12-15,17,34H,10-11H2,(H,30,36)(H,31,35)/t15-,17- YXHXDNMUMRMXLB-JCNLHEQBSA-N 226592 US9328096, 285 High affinity nerve growth factor receptor [441-796] Human 28.7 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226592 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226592&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962740 336293693 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396329 CN(C)C(=O)CNC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C26H22ClFN6O3/c1-33(2)24(35)15-30-26(37)22-14-23(34(32-22)16-8-4-3-5-9-16)31-25(36)17-12-18(20(28)13-19(17)27)21-10-6-7-11-29-21/h3-14H,15H2,1-2H3,(H,30,37)(H,31,36) BGZXKLKAZZRYGK-UHFFFAOYSA-N 226593 US9328096, 286 High affinity nerve growth factor receptor [441-796] Human 53.5 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226593 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226593&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962747 336293694 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396330 OC1(CNC(=O)c2cc(NC(=O)c3cc(c(F)cc3Cl)-c3ccccn3)n(n2)-c2ccccc2)COC1 InChI=1S/C26H21ClFN5O4/c27-19-11-20(28)18(21-8-4-5-9-29-21)10-17(19)24(34)31-23-12-22(25(35)30-13-26(36)14-37-15-26)32-33(23)16-6-2-1-3-7-16/h1-12,36H,13-15H2,(H,30,35)(H,31,34) PSFVAEZGYXUIRH-UHFFFAOYSA-N 226594 US9328096, 287 High affinity nerve growth factor receptor [441-796] Human 27.2 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226594 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226594&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962748 336293695 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396331 O[C@@H]1COC[C@H]1NC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C26H21ClFN5O4/c27-18-11-19(28)17(20-8-4-5-9-29-20)10-16(18)25(35)31-24-12-21(26(36)30-22-13-37-14-23(22)34)32-33(24)15-6-2-1-3-7-15/h1-12,22-23,34H,13-14H2,(H,30,36)(H,31,35)/t22-,23-/m1/s1 HOGJVCQYWDYRBI-DHIUTWEWSA-N 226595 US9328096, 288 High affinity nerve growth factor receptor [441-796] Human 45.5 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226595 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226595&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962749 336293696 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396332 CC(C)(CO)CNC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C27H25ClFN5O3/c1-27(2,16-35)15-31-26(37)23-14-24(34(33-23)17-8-4-3-5-9-17)32-25(36)18-12-19(21(29)13-20(18)28)22-10-6-7-11-30-22/h3-14,35H,15-16H2,1-2H3,(H,31,37)(H,32,36) SBYLOMIOTKRXEM-UHFFFAOYSA-N 226596 US9328096, 289 High affinity nerve growth factor receptor [441-796] Human 20.1 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226596 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226596&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962750 336293697 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396333 C[C@@H](O)CNC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C25H21ClFN5O3/c1-15(33)14-29-25(35)22-13-23(32(31-22)16-7-3-2-4-8-16)30-24(34)17-11-18(20(27)12-19(17)26)21-9-5-6-10-28-21/h2-13,15,33H,14H2,1H3,(H,29,35)(H,30,34)/t15-/m1/s1 SQNFLDXAPWEPLO-OAHLLOKOSA-N 226597 US9328096, 290 High affinity nerve growth factor receptor [441-796] Human 37.4 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226597 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226597&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962751 336293698 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396334 COCC(O)CNC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C26H23ClFN5O4/c1-37-15-17(34)14-30-26(36)23-13-24(33(32-23)16-7-3-2-4-8-16)31-25(35)18-11-19(21(28)12-20(18)27)22-9-5-6-10-29-22/h2-13,17,34H,14-15H2,1H3,(H,30,36)(H,31,35) XQJFZWWSIQQXIT-UHFFFAOYSA-N 226598 US9328096, 291 High affinity nerve growth factor receptor [441-796] Human 41.9 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226598 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226598&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962752 336293699 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396335 Fc1cc(Cl)c(cc1-c1ccccn1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCc1ccnnc1 InChI=1S/C27H19ClFN7O2/c28-21-13-22(29)20(23-8-4-5-10-30-23)12-19(21)26(37)34-25-14-24(35-36(25)18-6-2-1-3-7-18)27(38)31-15-17-9-11-32-33-16-17/h1-14,16H,15H2,(H,31,38)(H,34,37) NPWSONFFXKUUHJ-UHFFFAOYSA-N 226599 US9328096, 292 High affinity nerve growth factor receptor [441-796] Human 12.4 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226599 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226599&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962753 336293700 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396336 Fc1cc(Cl)c(cc1-c1ccccn1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCc1ncccn1 InChI=1S/C27H19ClFN7O2/c28-20-14-21(29)19(22-9-4-5-10-30-22)13-18(20)26(37)34-25-15-23(35-36(25)17-7-2-1-3-8-17)27(38)33-16-24-31-11-6-12-32-24/h1-15H,16H2,(H,33,38)(H,34,37) SNQKIGMVHNHYBY-UHFFFAOYSA-N 226600 US9328096, 293 High affinity nerve growth factor receptor [441-796] Human 50.4 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226600 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226600&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962754 336293701 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396337 Cn1cc(CNC(=O)c2cc(NC(=O)c3cc(c(F)cc3Cl)-c3ccccn3)n(n2)-c2ccccc2)cn1 InChI=1S/C27H21ClFN7O2/c1-35-16-17(15-32-35)14-31-27(38)24-13-25(36(34-24)18-7-3-2-4-8-18)33-26(37)19-11-20(22(29)12-21(19)28)23-9-5-6-10-30-23/h2-13,15-16H,14H2,1H3,(H,31,38)(H,33,37) GSTOCJIVBGIVHR-UHFFFAOYSA-N 226601 US9328096, 294 High affinity nerve growth factor receptor [441-796] Human 19.5 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226601 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226601&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962755 336293702 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396338 Cn1cncc1CNC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C27H21ClFN7O2/c1-35-16-30-14-18(35)15-32-27(38)24-13-25(36(34-24)17-7-3-2-4-8-17)33-26(37)19-11-20(22(29)12-21(19)28)23-9-5-6-10-31-23/h2-14,16H,15H2,1H3,(H,32,38)(H,33,37) QRMVKQCZNXRZOI-UHFFFAOYSA-N 226602 US9328096, 295 High affinity nerve growth factor receptor [441-796] Human 31.9 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226602 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226602&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962756 336293703 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396339 Cn1cc(CNC(=O)c2cc(NC(=O)c3cc(c(F)cc3Cl)-c3ccccn3)n(n2)-c2ccccc2)nn1 InChI=1S/C26H20ClFN8O2/c1-35-15-16(32-34-35)14-30-26(38)23-13-24(36(33-23)17-7-3-2-4-8-17)31-25(37)18-11-19(21(28)12-20(18)27)22-9-5-6-10-29-22/h2-13,15H,14H2,1H3,(H,30,38)(H,31,37) ZLARPCIIMFRYQG-UHFFFAOYSA-N 226603 US9328096, 296 High affinity nerve growth factor receptor [441-796] Human 15 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226603 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226603&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962757 336293704 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396340 Cn1nncc1CNC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C26H20ClFN8O2/c1-35-17(15-31-34-35)14-30-26(38)23-13-24(36(33-23)16-7-3-2-4-8-16)32-25(37)18-11-19(21(28)12-20(18)27)22-9-5-6-10-29-22/h2-13,15H,14H2,1H3,(H,30,38)(H,32,37) FCEHERDPOIKYOQ-UHFFFAOYSA-N 226604 US9328096, 297 High affinity nerve growth factor receptor [441-796] Human 21.4 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226604 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226604&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962758 336293705 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396341 Fc1cc(Cl)c(cc1-c1ccccn1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCCn1cncn1 InChI=1S/C26H20ClFN8O2/c27-20-13-21(28)19(22-8-4-5-9-30-22)12-18(20)25(37)33-24-14-23(34-36(24)17-6-2-1-3-7-17)26(38)31-10-11-35-16-29-15-32-35/h1-9,12-16H,10-11H2,(H,31,38)(H,33,37) SKDMVVDHQUNGLI-UHFFFAOYSA-N 226605 US9328096, 298 High affinity nerve growth factor receptor [441-796] Human 32.1 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226605 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226605&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962759 336293706 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396342 OC[C@H](O)CNC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C25H21ClFN5O4/c26-19-11-20(27)18(21-8-4-5-9-28-21)10-17(19)24(35)30-23-12-22(25(36)29-13-16(34)14-33)31-32(23)15-6-2-1-3-7-15/h1-12,16,33-34H,13-14H2,(H,29,36)(H,30,35)/t16-/m1/s1 HAIJTONPYJOFIJ-MRXNPFEDSA-N 226606 US9328096, 299 High affinity nerve growth factor receptor [441-796] Human 53.1 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226606 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226606&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962760 336293707 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396343 O[C@H]1CC[C@@H](CC1)NC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C28H25ClFN5O3/c29-22-15-23(30)21(24-8-4-5-13-31-24)14-20(22)27(37)33-26-16-25(34-35(26)18-6-2-1-3-7-18)28(38)32-17-9-11-19(36)12-10-17/h1-8,13-17,19,36H,9-12H2,(H,32,38)(H,33,37)/t17-,19- ZNRQPLHODFXGCA-UAPYVXQJSA-N 226607 US9328096, 300 High affinity nerve growth factor receptor [441-796] Human 20.9 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226607 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226607&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962761 336293708 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396344 O[C@H]1CC[C@H](CC1)NC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C28H25ClFN5O3/c29-22-15-23(30)21(24-8-4-5-13-31-24)14-20(22)27(37)33-26-16-25(34-35(26)18-6-2-1-3-7-18)28(38)32-17-9-11-19(36)12-10-17/h1-8,13-17,19,36H,9-12H2,(H,32,38)(H,33,37)/t17-,19+ ZNRQPLHODFXGCA-IZAXUBKRSA-N 226608 US9328096, 301 High affinity nerve growth factor receptor [441-796] Human 22 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226608 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226608&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962761 336293709 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396345 OCC1(CNC(=O)c2cc(NC(=O)c3cc(c(F)cc3Cl)-c3ccccn3)n(n2)-c2ccccc2)COC1 InChI=1S/C27H23ClFN5O4/c28-20-11-21(29)19(22-8-4-5-9-30-22)10-18(20)25(36)32-24-12-23(33-34(24)17-6-2-1-3-7-17)26(37)31-13-27(14-35)15-38-16-27/h1-12,35H,13-16H2,(H,31,37)(H,32,36) DYHMURVKMVAERV-UHFFFAOYSA-N 226609 US9328096, 302 High affinity nerve growth factor receptor [441-796] Human 24.1 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226609 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226609&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962762 336293710 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396346 CC1(O)CCC(CC1)NC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C29H27ClFN5O3/c1-29(39)12-10-18(11-13-29)33-28(38)25-17-26(36(35-25)19-7-3-2-4-8-19)34-27(37)20-15-21(23(31)16-22(20)30)24-9-5-6-14-32-24/h2-9,14-18,39H,10-13H2,1H3,(H,33,38)(H,34,37) LMMSUKROMXTZNB-UHFFFAOYSA-N 226610 US9328096, 303 High affinity nerve growth factor receptor [441-796] Human 9.77 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226610 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226610&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962763 336293711 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396347 Nc1cc(CNC(=O)c2cc(NC(=O)c3cc(c(F)cc3Cl)-c3ccccn3)n(n2)-c2ccccc2)ccn1 InChI=1S/C28H21ClFN7O2/c29-21-14-22(30)20(23-8-4-5-10-32-23)13-19(21)27(38)35-26-15-24(36-37(26)18-6-2-1-3-7-18)28(39)34-16-17-9-11-33-25(31)12-17/h1-15H,16H2,(H2,31,33)(H,34,39)(H,35,38) VVKHEXAAXNRPRD-UHFFFAOYSA-N 226611 US9328096, 304 High affinity nerve growth factor receptor [441-796] Human 1.71 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226611 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226611&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962764 336293712 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396348 Cc1n[nH]c(C)c1NC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C27H21ClFN7O2/c1-15-25(16(2)34-33-15)32-27(38)23-14-24(36(35-23)17-8-4-3-5-9-17)31-26(37)18-12-19(21(29)13-20(18)28)22-10-6-7-11-30-22/h3-14H,1-2H3,(H,31,37)(H,32,38)(H,33,34) KYOLGSXSPWJMIX-UHFFFAOYSA-N 226612 US9328096, 305 High affinity nerve growth factor receptor [441-796] Human 6.14 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226612 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226612&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962765 336293713 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396349 C[C@H](CN)NC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C25H22ClFN6O2/c1-15(14-28)30-25(35)21-13-22(33(32-21)17-6-3-2-4-7-17)31-24(34)18-12-16(9-10-19(18)26)23-20(27)8-5-11-29-23/h2-13,15H,14,28H2,1H3,(H,30,35)(H,31,34)/t15-/m1/s1 NYNCRAJQHCFVKR-OAHLLOKOSA-N 226613 US9328096, 306 High affinity nerve growth factor receptor [441-796] Human 79.8 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226613 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226613&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962766 336293714 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396350 NCCCNC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C25H22ClFN6O2/c26-19-10-9-16(23-20(27)8-4-12-29-23)14-18(19)24(34)31-22-15-21(25(35)30-13-5-11-28)32-33(22)17-6-2-1-3-7-17/h1-4,6-10,12,14-15H,5,11,13,28H2,(H,30,35)(H,31,34) LWELCNSHHUYGET-UHFFFAOYSA-N 226614 US9328096, 307 High affinity nerve growth factor receptor [441-796] Human 85.5 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226614 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226614&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962767 336293715 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396351 CC(CN)NC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C25H22ClFN6O2/c1-15(14-28)30-25(35)21-13-22(33(32-21)17-6-3-2-4-7-17)31-24(34)18-12-16(9-10-19(18)26)23-20(27)8-5-11-29-23/h2-13,15H,14,28H2,1H3,(H,30,35)(H,31,34) NYNCRAJQHCFVKR-UHFFFAOYSA-N 226615 US9328096, 308 High affinity nerve growth factor receptor [441-796] Human 190 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226615 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226615&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962768 336293716 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396352 C[C@@H](N)CNC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C25H22ClFN6O2/c1-15(28)14-30-25(35)21-13-22(33(32-21)17-6-3-2-4-7-17)31-24(34)18-12-16(9-10-19(18)26)23-20(27)8-5-11-29-23/h2-13,15H,14,28H2,1H3,(H,30,35)(H,31,34)/t15-/m1/s1 JMWCTQVSXOEURE-OAHLLOKOSA-N 226616 US9328096, 309 High affinity nerve growth factor receptor [441-796] Human 331 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226616 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226616&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962769 336293717 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396353 C[C@H](N)CNC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C25H22ClFN6O2/c1-15(28)14-30-25(35)21-13-22(33(32-21)17-6-3-2-4-7-17)31-24(34)18-12-16(9-10-19(18)26)23-20(27)8-5-11-29-23/h2-13,15H,14,28H2,1H3,(H,30,35)(H,31,34)/t15-/m0/s1 JMWCTQVSXOEURE-HNNXBMFYSA-N 226617 US9328096, 310 High affinity nerve growth factor receptor [441-796] Human 475 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226617 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226617&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962770 336293718 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396354 C[C@@H](CN)NC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C25H22ClFN6O2/c1-15(14-28)30-25(35)21-13-22(33(32-21)17-6-3-2-4-7-17)31-24(34)18-12-16(9-10-19(18)26)23-20(27)8-5-11-29-23/h2-13,15H,14,28H2,1H3,(H,30,35)(H,31,34)/t15-/m0/s1 NYNCRAJQHCFVKR-HNNXBMFYSA-N 226618 US9328096, 311 High affinity nerve growth factor receptor [441-796] Human 480 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226618 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226618&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962771 336293719 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396355 CNCCNC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C25H22ClFN6O2/c1-28-12-13-30-25(35)21-15-22(33(32-21)17-6-3-2-4-7-17)31-24(34)18-14-16(9-10-19(18)26)23-20(27)8-5-11-29-23/h2-11,14-15,28H,12-13H2,1H3,(H,30,35)(H,31,34) KAQMIBHPPCFVOD-UHFFFAOYSA-N 226619 US9328096, 312 High affinity nerve growth factor receptor [441-796] Human 743 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226619 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226619&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962772 336293720 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396356 N[C@H]1C[C@H](C1)NC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C26H22ClFN6O2/c27-20-9-8-15(24-21(28)7-4-10-30-24)11-19(20)25(35)32-23-14-22(26(36)31-17-12-16(29)13-17)33-34(23)18-5-2-1-3-6-18/h1-11,14,16-17H,12-13,29H2,(H,31,36)(H,32,35)/t16-,17+ UNTCQFPHUFEWLI-CALCHBBNSA-N 226620 US9328096, 313 High affinity nerve growth factor receptor [441-796] Human 196 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226620 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226620&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962773 336293721 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396357 N[C@H]1C[C@@H](C1)NC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C26H22ClFN6O2/c27-20-9-8-15(24-21(28)7-4-10-30-24)11-19(20)25(35)32-23-14-22(26(36)31-17-12-16(29)13-17)33-34(23)18-5-2-1-3-6-18/h1-11,14,16-17H,12-13,29H2,(H,31,36)(H,32,35)/t16-,17- UNTCQFPHUFEWLI-QAQDUYKDSA-N 226621 US9328096, 314 High affinity nerve growth factor receptor [441-796] Human 234 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226621 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226621&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962773 336293722 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396358 Fc1cccnc1-c1ccc(Cl)c(c1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NC1CCNC1 InChI=1S/C26H22ClFN6O2/c27-20-9-8-16(24-21(28)7-4-11-30-24)13-19(20)25(35)32-23-14-22(26(36)31-17-10-12-29-15-17)33-34(23)18-5-2-1-3-6-18/h1-9,11,13-14,17,29H,10,12,15H2,(H,31,36)(H,32,35) ONDZNCPQRMEAIH-UHFFFAOYSA-N 226622 US9328096, 315 High affinity nerve growth factor receptor [441-796] Human 294 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226622 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226622&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962774 336293723 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396359 Fc1cccnc1-c1ccc(Cl)c(c1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)N[C@@H]1CCNC1 InChI=1S/C26H22ClFN6O2/c27-20-9-8-16(24-21(28)7-4-11-30-24)13-19(20)25(35)32-23-14-22(26(36)31-17-10-12-29-15-17)33-34(23)18-5-2-1-3-6-18/h1-9,11,13-14,17,29H,10,12,15H2,(H,31,36)(H,32,35)/t17-/m1/s1 ONDZNCPQRMEAIH-QGZVFWFLSA-N 226623 US9328096, 316 High affinity nerve growth factor receptor [441-796] Human 301 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226623 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226623&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962775 336293724 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396360 Fc1cccnc1-c1ccc(Cl)c(c1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)N[C@H]1CCNC1 InChI=1S/C26H22ClFN6O2/c27-20-9-8-16(24-21(28)7-4-11-30-24)13-19(20)25(35)32-23-14-22(26(36)31-17-10-12-29-15-17)33-34(23)18-5-2-1-3-6-18/h1-9,11,13-14,17,29H,10,12,15H2,(H,31,36)(H,32,35)/t17-/m0/s1 ONDZNCPQRMEAIH-KRWDZBQOSA-N 226624 US9328096, 317 High affinity nerve growth factor receptor [441-796] Human 345 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226624 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226624&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962776 336293725 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396361 Fc1cccnc1-c1ccc(Cl)c(c1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCC1CNC1 InChI=1S/C26H22ClFN6O2/c27-20-9-8-17(24-21(28)7-4-10-30-24)11-19(20)25(35)32-23-12-22(26(36)31-15-16-13-29-14-16)33-34(23)18-5-2-1-3-6-18/h1-12,16,29H,13-15H2,(H,31,36)(H,32,35) LUNPRIYXXJDICU-UHFFFAOYSA-N 226625 US9328096, 318 High affinity nerve growth factor receptor [441-796] Human 8660 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226625 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226625&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962777 336293726 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396362 CC(CN)CNC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C26H24ClFN6O2/c1-16(14-29)15-31-26(36)22-13-23(34(33-22)18-6-3-2-4-7-18)32-25(35)19-12-17(9-10-20(19)27)24-21(28)8-5-11-30-24/h2-13,16H,14-15,29H2,1H3,(H,31,36)(H,32,35) VROUYVANZVHUPN-UHFFFAOYSA-N 226626 US9328096, 319 High affinity nerve growth factor receptor [441-796] Human 215 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226626 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226626&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962778 336293727 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396363 C[C@H](CCN)NC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C26H24ClFN6O2/c1-16(11-12-29)31-26(36)22-15-23(34(33-22)18-6-3-2-4-7-18)32-25(35)19-14-17(9-10-20(19)27)24-21(28)8-5-13-30-24/h2-10,13-16H,11-12,29H2,1H3,(H,31,36)(H,32,35)/t16-/m1/s1 HQFVKULPJIVZSB-MRXNPFEDSA-N 226627 US9328096, 320 High affinity nerve growth factor receptor [441-796] Human 320 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226627 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226627&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962779 336293728 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396364 CC(C)(CN)NC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C26H24ClFN6O2/c1-26(2,15-29)32-25(36)21-14-22(34(33-21)17-7-4-3-5-8-17)31-24(35)18-13-16(10-11-19(18)27)23-20(28)9-6-12-30-23/h3-14H,15,29H2,1-2H3,(H,31,35)(H,32,36) FOIMIYZPQURAMP-UHFFFAOYSA-N 226628 US9328096, 321 High affinity nerve growth factor receptor [441-796] Human 375 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226628 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226628&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962780 336293729 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396365 CC(C)(N)CNC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C26H24ClFN6O2/c1-26(2,29)15-31-25(36)21-14-22(34(33-21)17-7-4-3-5-8-17)32-24(35)18-13-16(10-11-19(18)27)23-20(28)9-6-12-30-23/h3-14H,15,29H2,1-2H3,(H,31,36)(H,32,35) LCBNVCNEENQTQS-UHFFFAOYSA-N 226629 US9328096, 322 High affinity nerve growth factor receptor [441-796] Human 471 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226629 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226629&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962781 336293730 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396366 CN[C@@H](C)CNC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C26H24ClFN6O2/c1-16(29-2)15-31-26(36)22-14-23(34(33-22)18-7-4-3-5-8-18)32-25(35)19-13-17(10-11-20(19)27)24-21(28)9-6-12-30-24/h3-14,16,29H,15H2,1-2H3,(H,31,36)(H,32,35)/t16-/m0/s1 CFLMYHHWUZPLDT-INIZCTEOSA-N 226630 US9328096, 323 High affinity nerve growth factor receptor [441-796] Human 573 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226630 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226630&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962782 336293731 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396367 C[C@H](N)CCNC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C26H24ClFN6O2/c1-16(29)11-13-31-26(36)22-15-23(34(33-22)18-6-3-2-4-7-18)32-25(35)19-14-17(9-10-20(19)27)24-21(28)8-5-12-30-24/h2-10,12,14-16H,11,13,29H2,1H3,(H,31,36)(H,32,35)/t16-/m0/s1 SSPYOSPSXMKTEH-INIZCTEOSA-N 226631 US9328096, 324 High affinity nerve growth factor receptor [441-796] Human 610 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226631 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226631&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962783 336293732 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396368 CNCCCNC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C26H24ClFN6O2/c1-29-12-6-14-31-26(36)22-16-23(34(33-22)18-7-3-2-4-8-18)32-25(35)19-15-17(10-11-20(19)27)24-21(28)9-5-13-30-24/h2-5,7-11,13,15-16,29H,6,12,14H2,1H3,(H,31,36)(H,32,35) QNDYYJZLUHXUCV-UHFFFAOYSA-N 226632 US9328096, 325 High affinity nerve growth factor receptor [441-796] Human 659 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226632 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226632&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962784 336293733 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396369 NCC(O)CNC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C25H22ClFN6O3/c26-19-9-8-15(23-20(27)7-4-10-29-23)11-18(19)24(35)31-22-12-21(25(36)30-14-17(34)13-28)32-33(22)16-5-2-1-3-6-16/h1-12,17,34H,13-14,28H2,(H,30,36)(H,31,35) QRDRACXRUZWUTE-UHFFFAOYSA-N 226633 US9328096, 326 High affinity nerve growth factor receptor [441-796] Human 859 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226633 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226633&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962785 336293734 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396370 NC(CF)CNC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C25H21ClF2N6O2/c26-19-9-8-15(23-20(28)7-4-10-30-23)11-18(19)24(35)32-22-12-21(25(36)31-14-16(29)13-27)33-34(22)17-5-2-1-3-6-17/h1-12,16H,13-14,29H2,(H,31,36)(H,32,35) LRHBIISUYADUIG-UHFFFAOYSA-N 226634 US9328096, 327 High affinity nerve growth factor receptor [441-796] Human 130 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226634 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226634&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962786 336293735 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396371 Fc1cccnc1-c1ccc(Cl)c(c1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)N[C@H]1[C@H]2CNC[C@@H]12 InChI=1S/C27H22ClFN6O2/c28-20-9-8-15(24-21(29)7-4-10-31-24)11-17(20)26(36)32-23-12-22(34-35(23)16-5-2-1-3-6-16)27(37)33-25-18-13-30-14-19(18)25/h1-12,18-19,25,30H,13-14H2,(H,32,36)(H,33,37)/t18-,19+,25- UCLIVVAOXRQBHH-HBNMSFMJSA-N 226635 US9328096, 328 High affinity nerve growth factor receptor [441-796] Human 223 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226635 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226635&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962787 336293736 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396372 Fc1cccnc1-c1ccc(Cl)c(c1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)N1C[C@@H]2C[C@H]1CN2 InChI=1S/C27H22ClFN6O2/c28-21-9-8-16(25-22(29)7-4-10-30-25)11-20(21)26(36)32-24-13-23(33-35(24)18-5-2-1-3-6-18)27(37)34-15-17-12-19(34)14-31-17/h1-11,13,17,19,31H,12,14-15H2,(H,32,36)/t17-,19-/m0/s1 ORHXRCRSSDUFQQ-HKUYNNGSSA-N 226636 US9328096, 329 High affinity nerve growth factor receptor [441-796] Human 241 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226636 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226636&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962788 336293737 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396373 Fc1cccnc1-c1ccc(Cl)c(c1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)N1C[C@H]2C[C@@H]1CN2 InChI=1S/C27H22ClFN6O2/c28-21-9-8-16(25-22(29)7-4-10-30-25)11-20(21)26(36)32-24-13-23(33-35(24)18-5-2-1-3-6-18)27(37)34-15-17-12-19(34)14-31-17/h1-11,13,17,19,31H,12,14-15H2,(H,32,36)/t17-,19-/m1/s1 ORHXRCRSSDUFQQ-IEBWSBKVSA-N 226637 US9328096, 330 High affinity nerve growth factor receptor [441-796] Human 328 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226637 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226637&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962789 336293738 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396374 Fc1cccnc1-c1ccc(Cl)c(c1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NC1CCNCC1 InChI=1S/C27H24ClFN6O2/c28-21-9-8-17(25-22(29)7-4-12-31-25)15-20(21)26(36)33-24-16-23(27(37)32-18-10-13-30-14-11-18)34-35(24)19-5-2-1-3-6-19/h1-9,12,15-16,18,30H,10-11,13-14H2,(H,32,37)(H,33,36) DTJAHSMPTQEYJY-UHFFFAOYSA-N 226638 US9328096, 331 High affinity nerve growth factor receptor [441-796] Human 159 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226638 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226638&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962790 336293739 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396375 Fc1cccnc1-c1ccc(Cl)c(c1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NC1CCCNC1 InChI=1S/C27H24ClFN6O2/c28-21-11-10-17(25-22(29)9-5-13-31-25)14-20(21)26(36)33-24-15-23(27(37)32-18-6-4-12-30-16-18)34-35(24)19-7-2-1-3-8-19/h1-3,5,7-11,13-15,18,30H,4,6,12,16H2,(H,32,37)(H,33,36) TWORNDMQXCPMBE-UHFFFAOYSA-N 226639 US9328096, 332 High affinity nerve growth factor receptor [441-796] Human 211 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226639 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226639&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962791 336293740 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396376 NC1(CNC(=O)c2cc(NC(=O)c3cc(ccc3Cl)-c3ncccc3F)n(n2)-c2ccccc2)CCC1 InChI=1S/C27H24ClFN6O2/c28-20-10-9-17(24-21(29)8-4-13-31-24)14-19(20)25(36)33-23-15-22(26(37)32-16-27(30)11-5-12-27)34-35(23)18-6-2-1-3-7-18/h1-4,6-10,13-15H,5,11-12,16,30H2,(H,32,37)(H,33,36) KXWOXVHXSQNQBK-UHFFFAOYSA-N 226640 US9328096, 333 High affinity nerve growth factor receptor [441-796] Human 270 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226640 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226640&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962792 336293741 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396377 N[C@H]1CC[C@@H](C1)NC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C27H24ClFN6O2/c28-21-11-8-16(25-22(29)7-4-12-31-25)13-20(21)26(36)33-24-15-23(27(37)32-18-10-9-17(30)14-18)34-35(24)19-5-2-1-3-6-19/h1-8,11-13,15,17-18H,9-10,14,30H2,(H,32,37)(H,33,36)/t17-,18-/m0/s1 XIAGPUVMYBCYJC-ROUUACIJSA-N 226641 US9328096, 334 High affinity nerve growth factor receptor [441-796] Human 296 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226641 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226641&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962793 336293742 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396378 N[C@@H]1CC[C@H](C1)NC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C27H24ClFN6O2/c28-21-11-8-16(25-22(29)7-4-12-31-25)13-20(21)26(36)33-24-15-23(27(37)32-18-10-9-17(30)14-18)34-35(24)19-5-2-1-3-6-19/h1-8,11-13,15,17-18H,9-10,14,30H2,(H,32,37)(H,33,36)/t17-,18-/m1/s1 XIAGPUVMYBCYJC-QZTJIDSGSA-N 226642 US9328096, 335 High affinity nerve growth factor receptor [441-796] Human 297 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226642 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226642&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962794 336293743 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396379 N[C@@H]1CCC[C@H]1NC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C27H24ClFN6O2/c28-19-12-11-16(25-20(29)8-5-13-31-25)14-18(19)26(36)33-24-15-23(27(37)32-22-10-4-9-21(22)30)34-35(24)17-6-2-1-3-7-17/h1-3,5-8,11-15,21-22H,4,9-10,30H2,(H,32,37)(H,33,36)/t21-,22-/m1/s1 YCEJQNRPNJHUNF-FGZHOGPDSA-N 226643 US9328096, 336 High affinity nerve growth factor receptor [441-796] Human 636 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226643 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226643&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962795 336293744 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396380 Fc1cccnc1-c1ccc(Cl)c(c1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NC[C@@H]1CCCN1 InChI=1S/C27H24ClFN6O2/c28-21-11-10-17(25-22(29)9-5-13-31-25)14-20(21)26(36)33-24-15-23(27(37)32-16-18-6-4-12-30-18)34-35(24)19-7-2-1-3-8-19/h1-3,5,7-11,13-15,18,30H,4,6,12,16H2,(H,32,37)(H,33,36)/t18-/m0/s1 ZXQORVVOEMTUEW-SFHVURJKSA-N 226644 US9328096, 337 High affinity nerve growth factor receptor [441-796] Human 657 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226644 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226644&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962796 336293745 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396381 Fc1cccnc1-c1ccc(Cl)c(c1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCC1CCCN1 InChI=1S/C27H24ClFN6O2/c28-21-11-10-17(25-22(29)9-5-13-31-25)14-20(21)26(36)33-24-15-23(27(37)32-16-18-6-4-12-30-18)34-35(24)19-7-2-1-3-8-19/h1-3,5,7-11,13-15,18,30H,4,6,12,16H2,(H,32,37)(H,33,36) ZXQORVVOEMTUEW-UHFFFAOYSA-N 226645 US9328096, 338 High affinity nerve growth factor receptor [441-796] Human 968 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226645 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226645&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962797 336293746 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396382 Fc1cccnc1-c1ccc(Cl)c(c1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCC1CCNC1 InChI=1S/C27H24ClFN6O2/c28-21-9-8-18(25-22(29)7-4-11-31-25)13-20(21)26(36)33-24-14-23(27(37)32-16-17-10-12-30-15-17)34-35(24)19-5-2-1-3-6-19/h1-9,11,13-14,17,30H,10,12,15-16H2,(H,32,37)(H,33,36) RNSHFANCHUEVLU-UHFFFAOYSA-N 226646 US9328096, 339 High affinity nerve growth factor receptor [441-796] Human 1180 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226646 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226646&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962798 336293747 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396383 Fc1cccnc1-c1ccc(Cl)c(c1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NC[C@H]1CCNC1 InChI=1S/C27H24ClFN6O2/c28-21-9-8-18(25-22(29)7-4-11-31-25)13-20(21)26(36)33-24-14-23(27(37)32-16-17-10-12-30-15-17)34-35(24)19-5-2-1-3-6-19/h1-9,11,13-14,17,30H,10,12,15-16H2,(H,32,37)(H,33,36)/t17-/m0/s1 RNSHFANCHUEVLU-KRWDZBQOSA-N 226647 US9328096, 340 High affinity nerve growth factor receptor [441-796] Human 1290 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226647 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226647&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962799 336293748 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396384 Fc1cccnc1-c1ccc(Cl)c(c1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NC[C@@H]1CCNC1 InChI=1S/C27H24ClFN6O2/c28-21-9-8-18(25-22(29)7-4-11-31-25)13-20(21)26(36)33-24-14-23(27(37)32-16-17-10-12-30-15-17)34-35(24)19-5-2-1-3-6-19/h1-9,11,13-14,17,30H,10,12,15-16H2,(H,32,37)(H,33,36)/t17-/m1/s1 RNSHFANCHUEVLU-QGZVFWFLSA-N 226648 US9328096, 341 High affinity nerve growth factor receptor [441-796] Human 1360 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226648 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226648&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962800 336293749 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396385 CN(C1CCNC1)C(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C27H24ClFN6O2/c1-34(19-11-13-30-16-19)27(37)23-15-24(35(33-23)18-6-3-2-4-7-18)32-26(36)20-14-17(9-10-21(20)28)25-22(29)8-5-12-31-25/h2-10,12,14-15,19,30H,11,13,16H2,1H3,(H,32,36) WTGMNJMPMNOKAV-UHFFFAOYSA-N 226649 US9328096, 342 High affinity nerve growth factor receptor [441-796] Human 1470 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226649 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226649&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962801 336293750 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396386 O[C@@H]1CNC[C@H]1NC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C26H22ClFN6O3/c27-18-9-8-15(24-19(28)7-4-10-30-24)11-17(18)25(36)32-23-12-20(26(37)31-21-13-29-14-22(21)35)33-34(23)16-5-2-1-3-6-16/h1-12,21-22,29,35H,13-14H2,(H,31,37)(H,32,36)/t21-,22-/m1/s1 LRYSXEPMNGTMIU-FGZHOGPDSA-N 226650 US9328096, 343 High affinity nerve growth factor receptor [441-796] Human 1010 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226650 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226650&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962802 336293751 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396387 OC1CNCC1NC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C26H22ClFN6O3/c27-18-9-8-15(24-19(28)7-4-10-30-24)11-17(18)25(36)32-23-12-20(26(37)31-21-13-29-14-22(21)35)33-34(23)16-5-2-1-3-6-16/h1-12,21-22,29,35H,13-14H2,(H,31,37)(H,32,36) LRYSXEPMNGTMIU-UHFFFAOYSA-N 226651 US9328096, 344 High affinity nerve growth factor receptor [441-796] Human 1060 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226651 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226651&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962803 336293752 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396388 O[C@H]1CNC[C@@H]1NC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C26H22ClFN6O3/c27-18-9-8-15(24-19(28)7-4-10-30-24)11-17(18)25(36)32-23-12-20(26(37)31-21-13-29-14-22(21)35)33-34(23)16-5-2-1-3-6-16/h1-12,21-22,29,35H,13-14H2,(H,31,37)(H,32,36)/t21-,22-/m0/s1 LRYSXEPMNGTMIU-VXKWHMMOSA-N 226652 US9328096, 345 High affinity nerve growth factor receptor [441-796] Human 1090 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226652 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226652&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962804 336293753 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396389 O[C@@H]1CNC[C@@H]1NC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C26H22ClFN6O3/c27-18-9-8-15(24-19(28)7-4-10-30-24)11-17(18)25(36)32-23-12-20(26(37)31-21-13-29-14-22(21)35)33-34(23)16-5-2-1-3-6-16/h1-12,21-22,29,35H,13-14H2,(H,31,37)(H,32,36)/t21-,22+/m0/s1 LRYSXEPMNGTMIU-FCHUYYIVSA-N 226653 US9328096, 346 High affinity nerve growth factor receptor [441-796] Human 1730 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226653 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226653&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962805 336293754 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396390 OC1(CNC(=O)c2cc(NC(=O)c3cc(ccc3Cl)-c3ncccc3F)n(n2)-c2ccccc2)CNC1 InChI=1S/C26H22ClFN6O3/c27-19-9-8-16(23-20(28)7-4-10-30-23)11-18(19)24(35)32-22-12-21(25(36)31-15-26(37)13-29-14-26)33-34(22)17-5-2-1-3-6-17/h1-12,29,37H,13-15H2,(H,31,36)(H,32,35) FLXNRSUYVCBYII-UHFFFAOYSA-N 226654 US9328096, 347 High affinity nerve growth factor receptor [441-796] Human 1920 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226654 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226654&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962806 336293755 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396391 NCCOCCNC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C26H24ClFN6O3/c27-20-9-8-17(24-21(28)7-4-11-30-24)15-19(20)25(35)32-23-16-22(26(36)31-12-14-37-13-10-29)33-34(23)18-5-2-1-3-6-18/h1-9,11,15-16H,10,12-14,29H2,(H,31,36)(H,32,35) NRAQJLLMIIZLCL-UHFFFAOYSA-N 226655 US9328096, 348 High affinity nerve growth factor receptor [441-796] Human 493 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226655 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226655&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962807 336293756 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396392 OCCNCCNC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C26H24ClFN6O3/c27-20-9-8-17(24-21(28)7-4-10-30-24)15-19(20)25(36)32-23-16-22(26(37)31-12-11-29-13-14-35)33-34(23)18-5-2-1-3-6-18/h1-10,15-16,29,35H,11-14H2,(H,31,37)(H,32,36) YQKVNURZKZZOFN-UHFFFAOYSA-N 226656 US9328096, 349 High affinity nerve growth factor receptor [441-796] Human 1110 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226656 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226656&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962808 336293757 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396393 NCC(F)(F)CNC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C25H20ClF3N6O2/c26-18-9-8-15(22-19(27)7-4-10-31-22)11-17(18)23(36)33-21-12-20(24(37)32-14-25(28,29)13-30)34-35(21)16-5-2-1-3-6-16/h1-12H,13-14,30H2,(H,32,37)(H,33,36) MUHLHLBATBVBQC-UHFFFAOYSA-N 226657 US9328096, 350 High affinity nerve growth factor receptor [441-796] Human 82.9 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226657 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226657&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962809 336293758 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396394 Fc1cccnc1-c1ccc(Cl)c(c1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)N[C@H]1CNC[C@H]1C#N InChI=1S/C27H21ClFN7O2/c28-20-9-8-16(25-21(29)7-4-10-32-25)11-19(20)26(37)34-24-12-22(35-36(24)18-5-2-1-3-6-18)27(38)33-23-15-31-14-17(23)13-30/h1-12,17,23,31H,14-15H2,(H,33,38)(H,34,37)/t17-,23+/m1/s1 SOTKPGZXZBGMGV-HXOBKFHXSA-N 226658 US9328096, 351 High affinity nerve growth factor receptor [441-796] Human 67.9 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226658 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226658&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962810 336293759 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396395 N[C@H]1CC[C@@H](CC1)NC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C28H26ClFN6O2/c29-22-13-8-17(26-23(30)7-4-14-32-26)15-21(22)27(37)34-25-16-24(35-36(25)20-5-2-1-3-6-20)28(38)33-19-11-9-18(31)10-12-19/h1-8,13-16,18-19H,9-12,31H2,(H,33,38)(H,34,37)/t18-,19- QXNLLCIPUPPQFG-WGSAOQKQSA-N 226659 US9328096, 352 High affinity nerve growth factor receptor [441-796] Human 114 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226659 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226659&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962811 336293760 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396396 N[C@H]1CC[C@H](CC1)NC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C28H26ClFN6O2/c29-22-13-8-17(26-23(30)7-4-14-32-26)15-21(22)27(37)34-25-16-24(35-36(25)20-5-2-1-3-6-20)28(38)33-19-11-9-18(31)10-12-19/h1-8,13-16,18-19H,9-12,31H2,(H,33,38)(H,34,37)/t18-,19+ QXNLLCIPUPPQFG-KDURUIRLSA-N 226660 US9328096, 353 High affinity nerve growth factor receptor [441-796] Human 164 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226660 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226660&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962811 336293761 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396397 Fc1cccnc1-c1ccc(Cl)c(c1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCC1CCNCC1 InChI=1S/C28H26ClFN6O2/c29-22-9-8-19(26-23(30)7-4-12-32-26)15-21(22)27(37)34-25-16-24(35-36(25)20-5-2-1-3-6-20)28(38)33-17-18-10-13-31-14-11-18/h1-9,12,15-16,18,31H,10-11,13-14,17H2,(H,33,38)(H,34,37) VDSWFDHBLMDMDO-UHFFFAOYSA-N 226661 US9328096, 354 High affinity nerve growth factor receptor [441-796] Human 834 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226661 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226661&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962812 336293762 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396398 OC[C@@H]1C[C@@H](CN1)NC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C27H24ClFN6O3/c28-21-9-8-16(25-22(29)7-4-10-30-25)11-20(21)26(37)33-24-13-23(34-35(24)19-5-2-1-3-6-19)27(38)32-17-12-18(15-36)31-14-17/h1-11,13,17-18,31,36H,12,14-15H2,(H,32,38)(H,33,37)/t17-,18-/m0/s1 NUXMFOPOIWGLIE-ROUUACIJSA-N 226662 US9328096, 355 High affinity nerve growth factor receptor [441-796] Human 882 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226662 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226662&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962813 336293763 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396399 FC1CNCCC1NC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C27H23ClF2N6O2/c28-19-9-8-16(25-20(29)7-4-11-32-25)13-18(19)26(37)34-24-14-23(35-36(24)17-5-2-1-3-6-17)27(38)33-22-10-12-31-15-21(22)30/h1-9,11,13-14,21-22,31H,10,12,15H2,(H,33,38)(H,34,37) QTCIMQSGFNGDBT-UHFFFAOYSA-N 226663 US9328096, 356 High affinity nerve growth factor receptor [441-796] Human 79.8 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226663 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226663&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962814 336293764 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396400 Fc1cccnc1-c1ccc(Cl)c(c1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCCC1CNCCO1 InChI=1S/C28H26ClFN6O3/c29-22-9-8-18(26-23(30)7-4-11-32-26)15-21(22)27(37)34-25-16-24(35-36(25)19-5-2-1-3-6-19)28(38)33-12-10-20-17-31-13-14-39-20/h1-9,11,15-16,20,31H,10,12-14,17H2,(H,33,38)(H,34,37) SWOXAGBXAFVFCA-UHFFFAOYSA-N 226664 US9328096, 357 High affinity nerve growth factor receptor [441-796] Human 131 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226664 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226664&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962815 336293765 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396401 COC1CN(C1)C(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C26H21ClFN5O3/c1-36-17-14-32(15-17)26(35)23-13-24(33(31-23)16-7-3-2-4-8-16)30-25(34)18-11-19(21(28)12-20(18)27)22-9-5-6-10-29-22/h2-13,17H,14-15H2,1H3,(H,30,34) YBZDHJSCPUAQJF-UHFFFAOYSA-N 226665 US9328096, 358 High affinity nerve growth factor receptor [441-796] Human 39.3 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226665 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226665&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962816 336293766 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396402 O[C@H]1CCN(C1)C(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C26H21ClFN5O3/c27-20-13-21(28)19(22-8-4-5-10-29-22)12-18(20)25(35)30-24-14-23(26(36)32-11-9-17(34)15-32)31-33(24)16-6-2-1-3-7-16/h1-8,10,12-14,17,34H,9,11,15H2,(H,30,35)/t17-/m0/s1 PTPBKURTJCVVJT-KRWDZBQOSA-N 226666 US9328096, 359 High affinity nerve growth factor receptor [441-796] Human 46.2 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226666 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226666&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962817 336293767 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396403 OC1CCN(C1)C(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C26H21ClFN5O3/c27-20-13-21(28)19(22-8-4-5-10-29-22)12-18(20)25(35)30-24-14-23(26(36)32-11-9-17(34)15-32)31-33(24)16-6-2-1-3-7-16/h1-8,10,12-14,17,34H,9,11,15H2,(H,30,35) PTPBKURTJCVVJT-UHFFFAOYSA-N 226667 US9328096, 360 High affinity nerve growth factor receptor [441-796] Human 47.2 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226667 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226667&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962818 336293768 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396404 O[C@@H]1CCN(C1)C(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C26H21ClFN5O3/c27-20-13-21(28)19(22-8-4-5-10-29-22)12-18(20)25(35)30-24-14-23(26(36)32-11-9-17(34)15-32)31-33(24)16-6-2-1-3-7-16/h1-8,10,12-14,17,34H,9,11,15H2,(H,30,35)/t17-/m1/s1 PTPBKURTJCVVJT-QGZVFWFLSA-N 226668 US9328096, 361 High affinity nerve growth factor receptor [441-796] Human 53.3 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226668 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226668&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962819 336293769 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396405 CN(C)CCNC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C26H24ClFN6O2/c1-33(2)13-12-30-26(36)23-16-24(34(32-23)17-8-4-3-5-9-17)31-25(35)18-14-19(21(28)15-20(18)27)22-10-6-7-11-29-22/h3-11,14-16H,12-13H2,1-2H3,(H,30,36)(H,31,35) FVEYAGOQGYTGPW-UHFFFAOYSA-N 226669 US9328096, 362 High affinity nerve growth factor receptor [441-796] Human 150 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226669 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226669&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962820 336293770 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396406 CC1(CN(C1)C(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1)C#N InChI=1S/C27H20ClFN6O2/c1-27(14-30)15-34(16-27)26(37)23-13-24(35(33-23)17-7-3-2-4-8-17)32-25(36)18-11-19(21(29)12-20(18)28)22-9-5-6-10-31-22/h2-13H,15-16H2,1H3,(H,32,36) VAGGAKCXAFRHLY-UHFFFAOYSA-N 226670 US9328096, 363 High affinity nerve growth factor receptor [441-796] Human 57.6 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226670 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226670&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962821 336293771 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396407 Fc1cc(Cl)c(cc1-c1ccccn1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)N1C2CC1COC2 InChI=1S/C27H21ClFN5O3/c28-21-12-22(29)20(23-8-4-5-9-30-23)11-19(21)26(35)31-25-13-24(32-34(25)16-6-2-1-3-7-16)27(36)33-17-10-18(33)15-37-14-17/h1-9,11-13,17-18H,10,14-15H2,(H,31,35) HKWIXPNYEBYQOI-UHFFFAOYSA-N 226671 US9328096, 364 High affinity nerve growth factor receptor [441-796] Human 74.3 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226671 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226671&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962822 336293772 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396408 CN1CC[C@H](C1)NC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C27H24ClFN6O2/c1-34-12-10-17(16-34)31-27(37)24-15-25(35(33-24)18-7-3-2-4-8-18)32-26(36)19-13-20(22(29)14-21(19)28)23-9-5-6-11-30-23/h2-9,11,13-15,17H,10,12,16H2,1H3,(H,31,37)(H,32,36)/t17-/m1/s1 VWCMNVGZFUYBMW-QGZVFWFLSA-N 226672 US9328096, 365 High affinity nerve growth factor receptor [441-796] Human 61.8 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226672 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226672&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962823 336293773 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396409 CN1CC[C@@H](C1)NC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C27H24ClFN6O2/c1-34-12-10-17(16-34)31-27(37)24-15-25(35(33-24)18-7-3-2-4-8-18)32-26(36)19-13-20(22(29)14-21(19)28)23-9-5-6-11-30-23/h2-9,11,13-15,17H,10,12,16H2,1H3,(H,31,37)(H,32,36)/t17-/m0/s1 VWCMNVGZFUYBMW-KRWDZBQOSA-N 226673 US9328096, 366 High affinity nerve growth factor receptor [441-796] Human 66.7 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226673&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962824 336293774 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396410 CN1CC(CNC(=O)c2cc(NC(=O)c3cc(c(F)cc3Cl)-c3ccccn3)n(n2)-c2ccccc2)C1 InChI=1S/C27H24ClFN6O2/c1-34-15-17(16-34)14-31-27(37)24-13-25(35(33-24)18-7-3-2-4-8-18)32-26(36)19-11-20(22(29)12-21(19)28)23-9-5-6-10-30-23/h2-13,17H,14-16H2,1H3,(H,31,37)(H,32,36) GOKCRODOVFYYSE-UHFFFAOYSA-N 226674 US9328096, 367 High affinity nerve growth factor receptor [441-796] Human 223 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226674 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226674&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962825 336293775 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396411 CN1CCN(CC1)C(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C27H24ClFN6O2/c1-33-11-13-34(14-12-33)27(37)24-17-25(35(32-24)18-7-3-2-4-8-18)31-26(36)19-15-20(22(29)16-21(19)28)23-9-5-6-10-30-23/h2-10,15-17H,11-14H2,1H3,(H,31,36) PNFASWVONZPNIH-UHFFFAOYSA-N 226675 US9328096, 368 High affinity nerve growth factor receptor [441-796] Human 228 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226675 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226675&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962826 336293776 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396412 OCC1CCCN1C(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C27H23ClFN5O3/c28-21-14-22(29)20(23-10-4-5-11-30-23)13-19(21)26(36)31-25-15-24(27(37)33-12-6-9-18(33)16-35)32-34(25)17-7-2-1-3-8-17/h1-5,7-8,10-11,13-15,18,35H,6,9,12,16H2,(H,31,36) DZDIYCUEJAQXKR-UHFFFAOYSA-N 226676 US9328096, 369 High affinity nerve growth factor receptor [441-796] Human 26.3 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226676 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226676&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962827 336293777 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396413 CO[C@@H]1CCN(C1)C(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C27H23ClFN5O3/c1-37-18-10-12-33(16-18)27(36)24-15-25(34(32-24)17-7-3-2-4-8-17)31-26(35)19-13-20(22(29)14-21(19)28)23-9-5-6-11-30-23/h2-9,11,13-15,18H,10,12,16H2,1H3,(H,31,35)/t18-/m1/s1 MBJURQXLWRIQLA-GOSISDBHSA-N 226677 US9328096, 370 High affinity nerve growth factor receptor [441-796] Human 61 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226677 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226677&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962828 336293778 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396414 OC[C@@H]1CCCN1C(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C27H23ClFN5O3/c28-21-14-22(29)20(23-10-4-5-11-30-23)13-19(21)26(36)31-25-15-24(27(37)33-12-6-9-18(33)16-35)32-34(25)17-7-2-1-3-8-17/h1-5,7-8,10-11,13-15,18,35H,6,9,12,16H2,(H,31,36)/t18-/m0/s1 DZDIYCUEJAQXKR-SFHVURJKSA-N 226678 US9328096, 371 High affinity nerve growth factor receptor [441-796] Human 72.9 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226678 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226678&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962829 336293779 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396415 O[C@H]1CN(C[C@H]1O)C(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C26H21ClFN5O4/c27-18-11-19(28)17(20-8-4-5-9-29-20)10-16(18)25(36)30-24-12-21(26(37)32-13-22(34)23(35)14-32)31-33(24)15-6-2-1-3-7-15/h1-12,22-23,34-35H,13-14H2,(H,30,36)/t22-,23+ JZMNKZFIRBQOIY-ZRZAMGCNSA-N 226679 US9328096, 372 High affinity nerve growth factor receptor [441-796] Human 134 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226679 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226679&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962830 336293780 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396416 O[C@@H]1CN(C[C@H]1O)C(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C26H21ClFN5O4/c27-18-11-19(28)17(20-8-4-5-9-29-20)10-16(18)25(36)30-24-12-21(26(37)32-13-22(34)23(35)14-32)31-33(24)15-6-2-1-3-7-15/h1-12,22-23,34-35H,13-14H2,(H,30,36)/t22-,23-/m1/s1 JZMNKZFIRBQOIY-DHIUTWEWSA-N 226680 US9328096, 373 High affinity nerve growth factor receptor [441-796] Human 741 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226680 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226680&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962831 336293781 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396417 CN(CC(C)(C)O)C(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C27H25ClFN5O3/c1-27(2,37)16-33(3)26(36)23-15-24(34(32-23)17-9-5-4-6-10-17)31-25(35)18-13-19(21(29)14-20(18)28)22-11-7-8-12-30-22/h4-15,37H,16H2,1-3H3,(H,31,35) PDDUWJPXWIRXIT-UHFFFAOYSA-N 226681 US9328096, 374 High affinity nerve growth factor receptor [441-796] Human 236 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226681 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226681&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962832 336293782 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396418 CN(CC(O)CO)C(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C26H23ClFN5O4/c1-32(14-17(35)15-34)26(37)23-13-24(33(31-23)16-7-3-2-4-8-16)30-25(36)18-11-19(21(28)12-20(18)27)22-9-5-6-10-29-22/h2-13,17,34-35H,14-15H2,1H3,(H,30,36) SBXGCSMIMVAGQY-UHFFFAOYSA-N 226682 US9328096, 375 High affinity nerve growth factor receptor [441-796] Human 85.8 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226682 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226682&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962833 336293783 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396419 OCCOCCNC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C26H23ClFN5O4/c27-20-15-21(28)19(22-8-4-5-9-29-22)14-18(20)25(35)31-24-16-23(26(36)30-10-12-37-13-11-34)32-33(24)17-6-2-1-3-7-17/h1-9,14-16,34H,10-13H2,(H,30,36)(H,31,35) GYOHPAJBSNECLJ-UHFFFAOYSA-N 226683 US9328096, 376 High affinity nerve growth factor receptor [441-796] Human 42.1 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226683 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226683&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962834 336293784 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396420 Cn1cnnc1CNC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C26H20ClFN8O2/c1-35-15-31-33-24(35)14-30-26(38)22-13-23(36(34-22)16-7-3-2-4-8-16)32-25(37)17-11-18(20(28)12-19(17)27)21-9-5-6-10-29-21/h2-13,15H,14H2,1H3,(H,30,38)(H,32,37) FKSGLLIWCQNAKW-UHFFFAOYSA-N 226684 US9328096, 377 High affinity nerve growth factor receptor [441-796] Human 198 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226684 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226684&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962835 336293785 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396421 Cc1noc(CNC(=O)c2cc(NC(=O)c3cc(c(F)cc3Cl)-c3ccccn3)n(n2)-c2ccccc2)n1 InChI=1S/C26H19ClFN7O3/c1-15-31-24(38-34-15)14-30-26(37)22-13-23(35(33-22)16-7-3-2-4-8-16)32-25(36)17-11-18(20(28)12-19(17)27)21-9-5-6-10-29-21/h2-13H,14H2,1H3,(H,30,37)(H,32,36) UBURPCYJYCCZKG-UHFFFAOYSA-N 226685 US9328096, 378 High affinity nerve growth factor receptor [441-796] Human 21.1 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226685 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226685&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962836 336293786 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396422 CN1CCN(CC1=O)C(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C27H22ClFN6O3/c1-33-11-12-34(16-25(33)36)27(38)23-15-24(35(32-23)17-7-3-2-4-8-17)31-26(37)18-13-19(21(29)14-20(18)28)22-9-5-6-10-30-22/h2-10,13-15H,11-12,16H2,1H3,(H,31,37) IOQWUWYCJYBDJZ-UHFFFAOYSA-N 226686 US9328096, 379 High affinity nerve growth factor receptor [441-796] Human 81.9 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226686 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226686&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962837 336293787 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396423 CN(C)[C@H]1CCN(C1)C(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C28H26ClFN6O2/c1-34(2)19-11-13-35(17-19)28(38)25-16-26(36(33-25)18-8-4-3-5-9-18)32-27(37)20-14-21(23(30)15-22(20)29)24-10-6-7-12-31-24/h3-10,12,14-16,19H,11,13,17H2,1-2H3,(H,32,37)/t19-/m0/s1 DNESHIHHQPTADG-IBGZPJMESA-N 226687 US9328096, 380 High affinity nerve growth factor receptor [441-796] Human 93.6 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226687 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226687&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962838 336293788 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396424 CN(C)[C@@H]1CCN(C1)C(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C28H26ClFN6O2/c1-34(2)19-11-13-35(17-19)28(38)25-16-26(36(33-25)18-8-4-3-5-9-18)32-27(37)20-14-21(23(30)15-22(20)29)24-10-6-7-12-31-24/h3-10,12,14-16,19H,11,13,17H2,1-2H3,(H,32,37)/t19-/m1/s1 DNESHIHHQPTADG-LJQANCHMSA-N 226688 US9328096, 381 High affinity nerve growth factor receptor [441-796] Human 105 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226688 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226688&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962839 336293789 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396425 CN(CCNC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1)C(C)=O InChI=1S/C27H24ClFN6O3/c1-17(36)34(2)13-12-31-27(38)24-16-25(35(33-24)18-8-4-3-5-9-18)32-26(37)19-14-20(22(29)15-21(19)28)23-10-6-7-11-30-23/h3-11,14-16H,12-13H2,1-2H3,(H,31,38)(H,32,37) RQCYMHVGMPFPID-UHFFFAOYSA-N 226689 US9328096, 382 High affinity nerve growth factor receptor [441-796] Human 50.6 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226689 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226689&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962840 336293790 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396426 O[C@@H]1CCOC[C@@H]1NC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C27H23ClFN5O4/c28-19-13-20(29)18(21-8-4-5-10-30-21)12-17(19)26(36)32-25-14-22(33-34(25)16-6-2-1-3-7-16)27(37)31-23-15-38-11-9-24(23)35/h1-8,10,12-14,23-24,35H,9,11,15H2,(H,31,37)(H,32,36)/t23-,24+/m0/s1 ZDBCHZVRGYSTNX-BJKOFHAPSA-N 226690 US9328096, 383 High affinity nerve growth factor receptor [441-796] Human 23.8 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226690 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226690&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962841 336293791 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396427 O[C@H]1CCOC[C@@H]1NC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C27H23ClFN5O4/c28-19-13-20(29)18(21-8-4-5-10-30-21)12-17(19)26(36)32-25-14-22(33-34(25)16-6-2-1-3-7-16)27(37)31-23-15-38-11-9-24(23)35/h1-8,10,12-14,23-24,35H,9,11,15H2,(H,31,37)(H,32,36)/t23-,24-/m0/s1 ZDBCHZVRGYSTNX-ZEQRLZLVSA-N 226691 US9328096, 384 High affinity nerve growth factor receptor [441-796] Human 24.7 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226691 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226691&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962842 336293792 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396428 O[C@H]1CCOC[C@H]1NC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C27H23ClFN5O4/c28-19-13-20(29)18(21-8-4-5-10-30-21)12-17(19)26(36)32-25-14-22(33-34(25)16-6-2-1-3-7-16)27(37)31-23-15-38-11-9-24(23)35/h1-8,10,12-14,23-24,35H,9,11,15H2,(H,31,37)(H,32,36)/t23-,24+/m1/s1 ZDBCHZVRGYSTNX-RPWUZVMVSA-N 226692 US9328096, 385 High affinity nerve growth factor receptor [441-796] Human 28.5 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226692 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226692&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962843 336293793 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396429 CC(=O)N1CCC(C1)NC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C28H24ClFN6O3/c1-17(37)35-12-10-18(16-35)32-28(39)25-15-26(36(34-25)19-7-3-2-4-8-19)33-27(38)20-13-21(23(30)14-22(20)29)24-9-5-6-11-31-24/h2-9,11,13-15,18H,10,12,16H2,1H3,(H,32,39)(H,33,38) GGYZZSILGHHPOP-UHFFFAOYSA-N 226693 US9328096, 386 High affinity nerve growth factor receptor [441-796] Human 59.4 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226693 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226693&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962844 336293794 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396430 OC[C@H]1COCCN1C(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C27H23ClFN5O4/c28-21-13-22(29)20(23-8-4-5-9-30-23)12-19(21)26(36)31-25-14-24(32-34(25)17-6-2-1-3-7-17)27(37)33-10-11-38-16-18(33)15-35/h1-9,12-14,18,35H,10-11,15-16H2,(H,31,36)/t18-/m0/s1 VWIVOOAPIKMDMO-SFHVURJKSA-N 226694 US9328096, 387 High affinity nerve growth factor receptor [441-796] Human 119 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226694 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226694&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962845 336293795 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396431 OC[C@@H]1COCCN1C(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C27H23ClFN5O4/c28-21-13-22(29)20(23-8-4-5-9-30-23)12-19(21)26(36)31-25-14-24(32-34(25)17-6-2-1-3-7-17)27(37)33-10-11-38-16-18(33)15-35/h1-9,12-14,18,35H,10-11,15-16H2,(H,31,36)/t18-/m1/s1 VWIVOOAPIKMDMO-GOSISDBHSA-N 226695 US9328096, 388 High affinity nerve growth factor receptor [441-796] Human 133 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226695 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226695&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962846 336293796 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396432 OCCCN(CCO)C(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C27H25ClFN5O4/c28-21-16-22(29)20(23-9-4-5-10-30-23)15-19(21)26(37)31-25-17-24(27(38)33(12-14-36)11-6-13-35)32-34(25)18-7-2-1-3-8-18/h1-5,7-10,15-17,35-36H,6,11-14H2,(H,31,37) NDZYFIPLUGSBSD-UHFFFAOYSA-N 226696 US9328096, 389 High affinity nerve growth factor receptor [441-796] Human 102 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226696 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226696&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962847 336293797 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396433 OCC(CO)(CO)NC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C26H23ClFN5O5/c27-19-11-20(28)18(21-8-4-5-9-29-21)10-17(19)24(37)30-23-12-22(25(38)31-26(13-34,14-35)15-36)32-33(23)16-6-2-1-3-7-16/h1-12,34-36H,13-15H2,(H,30,37)(H,31,38) RLAAQSFRXXFIMC-UHFFFAOYSA-N 226697 US9328096, 390 High affinity nerve growth factor receptor [441-796] Human 62.8 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226697 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226697&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962848 336293798 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396434 OC[C@H](O)[C@@H](O)CNC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C26H23ClFN5O5/c27-18-11-19(28)17(20-8-4-5-9-29-20)10-16(18)25(37)31-24-12-21(26(38)30-13-22(35)23(36)14-34)32-33(24)15-6-2-1-3-7-15/h1-12,22-23,34-36H,13-14H2,(H,30,38)(H,31,37)/t22-,23-/m0/s1 MHTSDKVQSIGNID-GOTSBHOMSA-N 226698 US9328096, 391 High affinity nerve growth factor receptor [441-796] Human 340 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226698 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226698&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962849 336293799 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396435 CC(NC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1)c1cncnc1 InChI=1S/C28H21ClFN7O2/c1-17(18-14-31-16-32-15-18)34-28(39)25-13-26(37(36-25)19-7-3-2-4-8-19)35-27(38)20-11-21(23(30)12-22(20)29)24-9-5-6-10-33-24/h2-17H,1H3,(H,34,39)(H,35,38) LUNXCJXMTHHNGQ-UHFFFAOYSA-N 226699 US9328096, 392 High affinity nerve growth factor receptor [441-796] Human 7.46 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226699 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226699&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962850 336293800 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396436 CN(Cc1ccncn1)C(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C28H21ClFN7O2/c1-36(16-18-10-12-31-17-33-18)28(39)25-15-26(37(35-25)19-7-3-2-4-8-19)34-27(38)20-13-21(23(30)14-22(20)29)24-9-5-6-11-32-24/h2-15,17H,16H2,1H3,(H,34,38) SZMVQQXQCMBWPA-UHFFFAOYSA-N 226700 US9328096, 393 High affinity nerve growth factor receptor [441-796] Human 32.9 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226700 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226700&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962851 336293801 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396437 CC(NC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1)c1ncccn1 InChI=1S/C28H21ClFN7O2/c1-17(26-32-12-7-13-33-26)34-28(39)24-16-25(37(36-24)18-8-3-2-4-9-18)35-27(38)19-14-20(22(30)15-21(19)29)23-10-5-6-11-31-23/h2-17H,1H3,(H,34,39)(H,35,38) RQOFUXRYBBUYOZ-UHFFFAOYSA-N 226701 US9328096, 394 High affinity nerve growth factor receptor [441-796] Human 48.2 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226701 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226701&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962852 336293802 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396438 CC(NC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1)c1cn(C)cn1 InChI=1S/C28H23ClFN7O2/c1-17(25-15-36(2)16-32-25)33-28(39)24-14-26(37(35-24)18-8-4-3-5-9-18)34-27(38)19-12-20(22(30)13-21(19)29)23-10-6-7-11-31-23/h3-17H,1-2H3,(H,33,39)(H,34,38) CMWOJCYMANIZIO-UHFFFAOYSA-N 226702 US9328096, 395 High affinity nerve growth factor receptor [441-796] Human 54.6 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226702 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226702&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962853 336293803 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396439 C[C@@H](NC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1)c1nccn1C InChI=1S/C28H23ClFN7O2/c1-17(26-32-12-13-36(26)2)33-28(39)24-16-25(37(35-24)18-8-4-3-5-9-18)34-27(38)19-14-20(22(30)15-21(19)29)23-10-6-7-11-31-23/h3-17H,1-2H3,(H,33,39)(H,34,38)/t17-/m1/s1 GJPYZTATEUSYBL-QGZVFWFLSA-N 226703 US9328096, 396 High affinity nerve growth factor receptor [441-796] Human 74.9 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226703 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226703&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962854 336293804 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396440 C[C@H](NC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1)c1nccn1C InChI=1S/C28H23ClFN7O2/c1-17(26-32-12-13-36(26)2)33-28(39)24-16-25(37(35-24)18-8-4-3-5-9-18)34-27(38)19-14-20(22(30)15-21(19)29)23-10-6-7-11-31-23/h3-17H,1-2H3,(H,33,39)(H,34,38)/t17-/m0/s1 GJPYZTATEUSYBL-KRWDZBQOSA-N 226704 US9328096, 397 High affinity nerve growth factor receptor [441-796] Human 88 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226704 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226704&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962855 336293805 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396441 Cn1cc(CCNC(=O)c2cc(NC(=O)c3cc(c(F)cc3Cl)-c3ccccn3)n(n2)-c2ccccc2)nn1 InChI=1S/C27H22ClFN8O2/c1-36-16-17(33-35-36)10-12-31-27(39)24-15-25(37(34-24)18-7-3-2-4-8-18)32-26(38)19-13-20(22(29)14-21(19)28)23-9-5-6-11-30-23/h2-9,11,13-16H,10,12H2,1H3,(H,31,39)(H,32,38) YJSFXMAJZPCOBA-UHFFFAOYSA-N 226705 US9328096, 398 High affinity nerve growth factor receptor [441-796] Human 18.8 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226705 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226705&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962856 336293806 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396442 CC(NC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1)c1nncn1C InChI=1S/C27H22ClFN8O2/c1-16(25-34-31-15-36(25)2)32-27(39)23-14-24(37(35-23)17-8-4-3-5-9-17)33-26(38)18-12-19(21(29)13-20(18)28)22-10-6-7-11-30-22/h3-16H,1-2H3,(H,32,39)(H,33,38) SWMWLDXNGDRXPZ-UHFFFAOYSA-N 226706 US9328096, 399 High affinity nerve growth factor receptor [441-796] Human 298 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226706 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226706&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962857 336293807 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396443 Cn1cnnc1CCNC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C27H22ClFN8O2/c1-36-16-32-34-24(36)10-12-31-27(39)23-15-25(37(35-23)17-7-3-2-4-8-17)33-26(38)18-13-19(21(29)14-20(18)28)22-9-5-6-11-30-22/h2-9,11,13-16H,10,12H2,1H3,(H,31,39)(H,33,38) APWWSWLXZTUXMR-UHFFFAOYSA-N 226707 US9328096, 400 High affinity nerve growth factor receptor [441-796] Human 613 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226707 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226707&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962858 336293808 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396444 Cc1noc(CCNC(=O)c2cc(NC(=O)c3cc(c(F)cc3Cl)-c3ccccn3)n(n2)-c2ccccc2)n1 InChI=1S/C27H21ClFN7O3/c1-16-32-25(39-35-16)10-12-31-27(38)23-15-24(36(34-23)17-7-3-2-4-8-17)33-26(37)18-13-19(21(29)14-20(18)28)22-9-5-6-11-30-22/h2-9,11,13-15H,10,12H2,1H3,(H,31,38)(H,33,37) XSGOLUDKDIFDNG-UHFFFAOYSA-N 226708 US9328096, 401 High affinity nerve growth factor receptor [441-796] Human 26.1 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226708 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226708&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962859 336293809 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396445 CN1CC(CNC(=O)c2cc(NC(=O)c3cc(c(F)cc3Cl)-c3ccccn3)n(n2)-c2ccccc2)CC1=O InChI=1S/C28H24ClFN6O3/c1-35-16-17(11-26(35)37)15-32-28(39)24-14-25(36(34-24)18-7-3-2-4-8-18)33-27(38)19-12-20(22(30)13-21(19)29)23-9-5-6-10-31-23/h2-10,12-14,17H,11,15-16H2,1H3,(H,32,39)(H,33,38) ZEXTWJPQIHSTDM-UHFFFAOYSA-N 226709 US9328096, 402 High affinity nerve growth factor receptor [441-796] Human 38 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226709 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226709&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962860 336293810 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396446 CC(=O)N1CCN(CC1)C(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C28H24ClFN6O3/c1-18(37)34-11-13-35(14-12-34)28(39)25-17-26(36(33-25)19-7-3-2-4-8-19)32-27(38)20-15-21(23(30)16-22(20)29)24-9-5-6-10-31-24/h2-10,15-17H,11-14H2,1H3,(H,32,38) PLNASWVPHMJIEN-UHFFFAOYSA-N 226710 US9328096, 403 High affinity nerve growth factor receptor [441-796] Human 130 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226710 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226710&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962861 336293811 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396447 CN(C)C1CCN(CC1)C(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C29H28ClFN6O2/c1-35(2)19-11-14-36(15-12-19)29(39)26-18-27(37(34-26)20-8-4-3-5-9-20)33-28(38)21-16-22(24(31)17-23(21)30)25-10-6-7-13-32-25/h3-10,13,16-19H,11-12,14-15H2,1-2H3,(H,33,38) BLTUOAAFFOKJGT-UHFFFAOYSA-N 226711 US9328096, 404 High affinity nerve growth factor receptor [441-796] Human 254 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226711 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226711&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962862 336293812 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396448 OCC(NC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1)C(F)(F)F InChI=1S/C25H18ClF4N5O3/c26-17-11-18(27)16(19-8-4-5-9-31-19)10-15(17)23(37)33-22-12-20(24(38)32-21(13-36)25(28,29)30)34-35(22)14-6-2-1-3-7-14/h1-12,21,36H,13H2,(H,32,38)(H,33,37) CRZMIZOKXMCFDU-UHFFFAOYSA-N 226712 US9328096, 405 High affinity nerve growth factor receptor [441-796] Human 36.2 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226712 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226712&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962863 336293813 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396449 Fc1cc(Cl)c(cc1-c1ccccn1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCCN1CCOCC1 InChI=1S/C28H26ClFN6O3/c29-22-17-23(30)21(24-8-4-5-9-31-24)16-20(22)27(37)33-26-18-25(34-36(26)19-6-2-1-3-7-19)28(38)32-10-11-35-12-14-39-15-13-35/h1-9,16-18H,10-15H2,(H,32,38)(H,33,37) VPPSVWJFYPPEBY-UHFFFAOYSA-N 226713 US9328096, 406 High affinity nerve growth factor receptor [441-796] Human 93.2 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226713 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226713&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962864 336293814 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396450 OCC1(CO)CCCN1C(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C28H25ClFN5O4/c29-21-14-22(30)20(23-9-4-5-11-31-23)13-19(21)26(38)32-25-15-24(33-35(25)18-7-2-1-3-8-18)27(39)34-12-6-10-28(34,16-36)17-37/h1-5,7-9,11,13-15,36-37H,6,10,12,16-17H2,(H,32,38) FEAZPJCNVKVQND-UHFFFAOYSA-N 226714 US9328096, 407 High affinity nerve growth factor receptor [441-796] Human 127 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226714 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226714&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962865 336293815 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396451 OCC1(O)CCN(CC1)C(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C28H25ClFN5O4/c29-21-15-22(30)20(23-8-4-5-11-31-23)14-19(21)26(37)32-25-16-24(33-35(25)18-6-2-1-3-7-18)27(38)34-12-9-28(39,17-36)10-13-34/h1-8,11,14-16,36,39H,9-10,12-13,17H2,(H,32,37) VFSUTQZNZCRAFA-UHFFFAOYSA-N 226715 US9328096, 408 High affinity nerve growth factor receptor [441-796] Human 296 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226715 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226715&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962866 336293816 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396452 CN(C)CCC(O)CNC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C28H28ClFN6O3/c1-35(2)13-11-19(37)17-32-28(39)25-16-26(36(34-25)18-8-4-3-5-9-18)33-27(38)20-14-21(23(30)15-22(20)29)24-10-6-7-12-31-24/h3-10,12,14-16,19,37H,11,13,17H2,1-2H3,(H,32,39)(H,33,38) GPFMWIWJFCQVAB-UHFFFAOYSA-N 226716 US9328096, 409 High affinity nerve growth factor receptor [441-796] Human 132 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226716 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226716&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962867 336293817 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396453 COCC(CN(C)C)NC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C28H28ClFN6O3/c1-35(2)16-18(17-39-3)32-28(38)25-15-26(36(34-25)19-9-5-4-6-10-19)33-27(37)20-13-21(23(30)14-22(20)29)24-11-7-8-12-31-24/h4-15,18H,16-17H2,1-3H3,(H,32,38)(H,33,37) IUWBMRAGNVXQGF-UHFFFAOYSA-N 226717 US9328096, 410 High affinity nerve growth factor receptor [441-796] Human 366 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226717 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226717&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962868 336293818 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396454 OC[C@H]1[C@H](O)[C@@H](O)CN1C(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C27H23ClFN5O5/c28-18-11-19(29)17(20-8-4-5-9-30-20)10-16(18)26(38)31-24-12-21(32-34(24)15-6-2-1-3-7-15)27(39)33-13-23(36)25(37)22(33)14-35/h1-12,22-23,25,35-37H,13-14H2,(H,31,38)/t22-,23-,25-/m0/s1 QKUHIHZKSFOKNJ-LSQMVHIFSA-N 226718 US9328096, 411 High affinity nerve growth factor receptor [441-796] Human 1460 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226718 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226718&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962869 336293819 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396455 CN1CCN(CCNC(=O)c2cc(NC(=O)c3cc(c(F)cc3Cl)-c3ccccn3)n(n2)-c2ccccc2)CC1 InChI=1S/C29H29ClFN7O2/c1-36-13-15-37(16-14-36)12-11-33-29(40)26-19-27(38(35-26)20-7-3-2-4-8-20)34-28(39)21-17-22(24(31)18-23(21)30)25-9-5-6-10-32-25/h2-10,17-19H,11-16H2,1H3,(H,33,40)(H,34,39) INGAAROOTBMHFH-UHFFFAOYSA-N 226719 US9328096, 412 High affinity nerve growth factor receptor [441-796] Human 101 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226719 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226719&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962870 336293820 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396456 Fc1cc(Cl)c(cc1-c1ccccn1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCC(=O)N1CCOCC1 InChI=1S/C28H24ClFN6O4/c29-21-15-22(30)20(23-8-4-5-9-31-23)14-19(21)27(38)33-25-16-24(34-36(25)18-6-2-1-3-7-18)28(39)32-17-26(37)35-10-12-40-13-11-35/h1-9,14-16H,10-13,17H2,(H,32,39)(H,33,38) IXNORKGYXOEOFD-UHFFFAOYSA-N 226720 US9328096, 413 High affinity nerve growth factor receptor [441-796] Human 147 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226720 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226720&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962871 336293821 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396457 Fc1cc(Cl)c(cc1-c1ccccn1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCc1cnco1 InChI=1S/C26H18ClFN6O3/c27-20-11-21(28)19(22-8-4-5-9-30-22)10-18(20)25(35)32-24-12-23(26(36)31-14-17-13-29-15-37-17)33-34(24)16-6-2-1-3-7-16/h1-13,15H,14H2,(H,31,36)(H,32,35) WSRKIHDXAGSLNN-UHFFFAOYSA-N 226721 US9328096, 414 High affinity nerve growth factor receptor [441-796] Human 16.2 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226721 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226721&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962872 336293822 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396458 Fc1cc(Cl)c(cc1-c1ccccn1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCc1ccno1 InChI=1S/C26H18ClFN6O3/c27-20-13-21(28)19(22-8-4-5-10-29-22)12-18(20)25(35)32-24-14-23(26(36)30-15-17-9-11-31-37-17)33-34(24)16-6-2-1-3-7-16/h1-14H,15H2,(H,30,36)(H,32,35) LQTMTIQSNSMVEU-UHFFFAOYSA-N 226722 US9328096, 415 High affinity nerve growth factor receptor [441-796] Human 12.8 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226722 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226722&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962873 336293823 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396459 Cn1nncc1CNC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccc(F)cn2)n(n1)-c1ccccc1 InChI=1S/C26H19Cl2FN8O2/c1-36-17(14-32-35-36)13-31-26(39)23-11-24(37(34-23)16-5-3-2-4-6-16)33-25(38)19-9-18(20(27)10-21(19)28)22-8-7-15(29)12-30-22/h2-12,14H,13H2,1H3,(H,31,39)(H,33,38) ADOUFXNJPPLGRP-UHFFFAOYSA-N 226723 US9328096, 416 High affinity nerve growth factor receptor [441-796] Human 26 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226723 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226723&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962874 336293824 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396460 Fc1ccc(nc1)-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)NCc2ccon2)c(Cl)cc1Cl InChI=1S/C26H17Cl2FN6O3/c27-20-11-21(28)19(10-18(20)22-7-6-15(29)13-30-22)25(36)32-24-12-23(26(37)31-14-16-8-9-38-34-16)33-35(24)17-4-2-1-3-5-17/h1-13H,14H2,(H,31,37)(H,32,36) PAFSNJWNKLDDQS-UHFFFAOYSA-N 226724 US9328096, 417 High affinity nerve growth factor receptor [441-796] Human 27.4 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226724 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226724&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962875 336293825 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396461 OCCC1(COC1)NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccc(F)cn2)n(n1)-c1ccccc1 InChI=1S/C27H22Cl2FN5O4/c28-20-11-21(29)19(10-18(20)22-7-6-16(30)13-31-22)25(37)32-24-12-23(34-35(24)17-4-2-1-3-5-17)26(38)33-27(8-9-36)14-39-15-27/h1-7,10-13,36H,8-9,14-15H2,(H,32,37)(H,33,38) AJUYTELFJDPECU-UHFFFAOYSA-N 226725 US9328096, 418 High affinity nerve growth factor receptor [441-796] Human 34.6 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226725 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226725&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962876 336293826 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396462 Fc1ccc(nc1)-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)NCC2(F)COC2)c(Cl)cc1Cl InChI=1S/C26H19Cl2F2N5O3/c27-19-9-20(28)18(8-17(19)21-7-6-15(29)11-31-21)24(36)33-23-10-22(25(37)32-12-26(30)13-38-14-26)34-35(23)16-4-2-1-3-5-16/h1-11H,12-14H2,(H,32,37)(H,33,36) DDRDDAWYOYDVQC-UHFFFAOYSA-N 226726 US9328096, 419 High affinity nerve growth factor receptor [441-796] Human 34.2 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226726 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226726&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962877 336293827 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396463 Fc1ccc(nc1)-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)NCc2nnco2)c(Cl)cc1Cl InChI=1S/C25H16Cl2FN7O3/c26-18-9-19(27)17(8-16(18)20-7-6-14(28)11-29-20)24(36)32-22-10-21(25(37)30-12-23-33-31-13-38-23)34-35(22)15-4-2-1-3-5-15/h1-11,13H,12H2,(H,30,37)(H,32,36) SJMISGCAHYIJET-UHFFFAOYSA-N 226727 US9328096, 420 High affinity nerve growth factor receptor [441-796] Human 253 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226727 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226727&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962878 336293828 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396464 OCC1(CC1)NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccc(F)cn2)n(n1)-c1ccccc1 InChI=1S/C26H20Cl2FN5O3/c27-19-11-20(28)18(10-17(19)21-7-6-15(29)13-30-21)24(36)31-23-12-22(25(37)32-26(14-35)8-9-26)33-34(23)16-4-2-1-3-5-16/h1-7,10-13,35H,8-9,14H2,(H,31,36)(H,32,37) PNMAHISCBTVOIH-UHFFFAOYSA-N 226728 US9328096, 421 High affinity nerve growth factor receptor [441-796] Human 21.3 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226728 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226728&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962879 336293829 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396465 CC1(O)CCC(CC1)NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccc(F)cn2)n(n1)-c1ccccc1 InChI=1S/C29H26Cl2FN5O3/c1-29(40)11-9-18(10-12-29)34-28(39)25-15-26(37(36-25)19-5-3-2-4-6-19)35-27(38)21-13-20(22(30)14-23(21)31)24-8-7-17(32)16-33-24/h2-8,13-16,18,40H,9-12H2,1H3,(H,34,39)(H,35,38) MEWMFGAGFYCYOQ-UHFFFAOYSA-N 226729 US9328096, 422 High affinity nerve growth factor receptor [441-796] Human 2.96 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226729 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226729&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962880 336293830 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396466 Fc1ccc(nc1)-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)NCc2ncco2)c(Cl)cc1Cl InChI=1S/C26H17Cl2FN6O3/c27-19-11-20(28)18(10-17(19)21-7-6-15(29)13-31-21)25(36)33-23-12-22(26(37)32-14-24-30-8-9-38-24)34-35(23)16-4-2-1-3-5-16/h1-13H,14H2,(H,32,37)(H,33,36) IGNNSNCNERDDKV-UHFFFAOYSA-N 226730 US9328096, 423 High affinity nerve growth factor receptor [441-796] Human 101 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226730 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226730&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962881 336293831 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396467 Fc1ccc(nc1)-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)NCc2ccccn2)c(Cl)cc1Cl InChI=1S/C28H19Cl2FN6O2/c29-22-13-23(30)21(12-20(22)24-10-9-17(31)15-33-24)27(38)35-26-14-25(36-37(26)19-7-2-1-3-8-19)28(39)34-16-18-6-4-5-11-32-18/h1-15H,16H2,(H,34,39)(H,35,38) KUECGIDGCGVGMN-UHFFFAOYSA-N 226731 US9328096, 424 High affinity nerve growth factor receptor [441-796] Human 25.9 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226731 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226731&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962882 336293832 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396468 Fc1ccc(nc1)-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)NCC2CCOC2)c(Cl)cc1Cl InChI=1S/C27H22Cl2FN5O3/c28-21-11-22(29)20(10-19(21)23-7-6-17(30)14-31-23)26(36)33-25-12-24(27(37)32-13-16-8-9-38-15-16)34-35(25)18-4-2-1-3-5-18/h1-7,10-12,14,16H,8-9,13,15H2,(H,32,37)(H,33,36) HGHFSHRNSFNNHO-UHFFFAOYSA-N 226732 US9328096, 425 High affinity nerve growth factor receptor [441-796] Human 22.8 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226732 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226732&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962883 336293833 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396469 Fc1ccc(nc1)-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)NCc2cc[nH]n2)c(Cl)cc1Cl InChI=1S/C26H18Cl2FN7O2/c27-20-11-21(28)19(10-18(20)22-7-6-15(29)13-30-22)25(37)33-24-12-23(26(38)31-14-16-8-9-32-34-16)35-36(24)17-4-2-1-3-5-17/h1-13H,14H2,(H,31,38)(H,32,34)(H,33,37) UYUFQTUZVVVMFV-UHFFFAOYSA-N 226733 US9328096, 426 High affinity nerve growth factor receptor [441-796] Human 19.3 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226733 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226733&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962884 336293834 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396470 OCC1(COC1)NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccc(F)cn2)n(n1)-c1ccccc1 InChI=1S/C26H20Cl2FN5O4/c27-19-9-20(28)18(8-17(19)21-7-6-15(29)11-30-21)24(36)31-23-10-22(25(37)32-26(12-35)13-38-14-26)33-34(23)16-4-2-1-3-5-16/h1-11,35H,12-14H2,(H,31,36)(H,32,37) CEWSCNZGIKQTFK-UHFFFAOYSA-N 226734 US9328096, 427 High affinity nerve growth factor receptor [441-796] Human 47.1 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226734 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226734&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962885 336293835 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396471 Fc1ccc(nc1)-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)NCc2nnc[nH]2)c(Cl)cc1Cl InChI=1S/C25H17Cl2FN8O2/c26-18-9-19(27)17(8-16(18)20-7-6-14(28)11-29-20)24(37)33-23-10-21(25(38)30-12-22-31-13-32-34-22)35-36(23)15-4-2-1-3-5-15/h1-11,13H,12H2,(H,30,38)(H,33,37)(H,31,32,34) AUAQWOGBEXNTTA-UHFFFAOYSA-N 226735 US9328096, 428 High affinity nerve growth factor receptor [441-796] Human 49 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226735 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226735&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962886 336293836 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396472 CN(C)C(=O)CNC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccc(F)cn2)n(n1)-c1ccccc1 InChI=1S/C26H21Cl2FN6O3/c1-34(2)24(36)14-31-26(38)22-12-23(35(33-22)16-6-4-3-5-7-16)32-25(37)18-10-17(19(27)11-20(18)28)21-9-8-15(29)13-30-21/h3-13H,14H2,1-2H3,(H,31,38)(H,32,37) DXVVOKBLHUBMCP-UHFFFAOYSA-N 226736 US9328096, 429 High affinity nerve growth factor receptor [441-796] Human 73.4 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226736 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226736&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962887 336293837 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396473 Cc1nnc(CNC(=O)c2cc(NC(=O)c3cc(c(Cl)cc3Cl)-c3ccc(F)cn3)n(n2)-c2ccccc2)o1 InChI=1S/C26H18Cl2FN7O3/c1-14-33-34-24(39-14)13-31-26(38)22-11-23(36(35-22)16-5-3-2-4-6-16)32-25(37)18-9-17(19(27)10-20(18)28)21-8-7-15(29)12-30-21/h2-12H,13H2,1H3,(H,31,38)(H,32,37) ZWICHIFRZYQTFL-UHFFFAOYSA-N 226737 US9328096, 430 High affinity nerve growth factor receptor [441-796] Human 32.8 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226737 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226737&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962888 336293838 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396474 Fc1ccc(nc1)-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)N[C@H]2CCOC2)c(Cl)cc1Cl InChI=1S/C26H20Cl2FN5O3/c27-20-11-21(28)19(10-18(20)22-7-6-15(29)13-30-22)25(35)32-24-12-23(26(36)31-16-8-9-37-14-16)33-34(24)17-4-2-1-3-5-17/h1-7,10-13,16H,8-9,14H2,(H,31,36)(H,32,35)/t16-/m0/s1 JNFMIYGKYOMTHP-INIZCTEOSA-N 226738 US9328096, 431 High affinity nerve growth factor receptor [441-796] Human 42 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226738 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226738&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962889 336293839 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396475 CC(CO)NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccc(F)cn2)n(n1)-c1ccccc1 InChI=1S/C25H20Cl2FN5O3/c1-14(13-34)30-25(36)22-11-23(33(32-22)16-5-3-2-4-6-16)31-24(35)18-9-17(19(26)10-20(18)27)21-8-7-15(28)12-29-21/h2-12,14,34H,13H2,1H3,(H,30,36)(H,31,35) QSYMOHRZVOTNKG-UHFFFAOYSA-N 226739 US9328096, 432 High affinity nerve growth factor receptor [441-796] Human 30.4 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226739 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226739&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962890 336293840 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396476 Cn1cc(CNC(=O)c2cc(NC(=O)c3cc(c(Cl)cc3Cl)-c3ccc(F)cn3)n(n2)-c2ccccc2)cn1 InChI=1S/C27H20Cl2FN7O2/c1-36-15-16(13-33-36)12-32-27(39)24-11-25(37(35-24)18-5-3-2-4-6-18)34-26(38)20-9-19(21(28)10-22(20)29)23-8-7-17(30)14-31-23/h2-11,13-15H,12H2,1H3,(H,32,39)(H,34,38) HRBWNKAHMXKELB-UHFFFAOYSA-N 226740 US9328096, 433 High affinity nerve growth factor receptor [441-796] Human 28.3 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226740 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226740&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962891 336293841 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396477 Fc1ccc(nc1)-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)NCc2cocn2)c(Cl)cc1Cl InChI=1S/C26H17Cl2FN6O3/c27-20-9-21(28)19(8-18(20)22-7-6-15(29)11-30-22)25(36)33-24-10-23(26(37)31-12-16-13-38-14-32-16)34-35(24)17-4-2-1-3-5-17/h1-11,13-14H,12H2,(H,31,37)(H,33,36) XRIYFLRQZNJDKD-UHFFFAOYSA-N 226741 US9328096, 434 High affinity nerve growth factor receptor [441-796] Human 21.4 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226741 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226741&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962892 336293842 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396478 Fc1ccc(nc1)-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)NC2CC2)c(Cl)cc1Cl InChI=1S/C25H18Cl2FN5O2/c26-19-11-20(27)18(10-17(19)21-9-6-14(28)13-29-21)24(34)31-23-12-22(25(35)30-15-7-8-15)32-33(23)16-4-2-1-3-5-16/h1-6,9-13,15H,7-8H2,(H,30,35)(H,31,34) TUMGITYTNHVFLP-UHFFFAOYSA-N 226742 US9328096, 435 High affinity nerve growth factor receptor [441-796] Human 80.3 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226742 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226742&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962893 336293843 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396479 CCNC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccc(F)cn2)n(n1)-c1ccccc1 InChI=1S/C24H18Cl2FN5O2/c1-2-28-24(34)21-12-22(32(31-21)15-6-4-3-5-7-15)30-23(33)17-10-16(18(25)11-19(17)26)20-9-8-14(27)13-29-20/h3-13H,2H2,1H3,(H,28,34)(H,30,33) SRYXUKGCQCUDNZ-UHFFFAOYSA-N 226743 US9328096, 436 High affinity nerve growth factor receptor [441-796] Human 37 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226743 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226743&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962894 336293844 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396480 Fc1ccc(nc1)-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)NC2CCOCC2)c(Cl)cc1Cl InChI=1S/C27H22Cl2FN5O3/c28-21-13-22(29)20(12-19(21)23-7-6-16(30)15-31-23)26(36)33-25-14-24(27(37)32-17-8-10-38-11-9-17)34-35(25)18-4-2-1-3-5-18/h1-7,12-15,17H,8-11H2,(H,32,37)(H,33,36) ZDHRTAJUWZFUMR-UHFFFAOYSA-N 226744 US9328096, 437 High affinity nerve growth factor receptor [441-796] Human 28.3 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226744 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226744&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962895 336293845 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396481 Fc1ccc(nc1)-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)NCc2cnccn2)c(Cl)cc1Cl InChI=1S/C27H18Cl2FN7O2/c28-21-11-22(29)20(10-19(21)23-7-6-16(30)13-33-23)26(38)35-25-12-24(36-37(25)18-4-2-1-3-5-18)27(39)34-15-17-14-31-8-9-32-17/h1-14H,15H2,(H,34,39)(H,35,38) UNGKCFKUAYEYLI-UHFFFAOYSA-N 226745 US9328096, 438 High affinity nerve growth factor receptor [441-796] Human 13.4 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226745 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226745&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962896 336293846 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396482 Fc1ccc(nc1)-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)NC2COC2)c(Cl)cc1Cl InChI=1S/C25H18Cl2FN5O3/c26-19-9-20(27)18(8-17(19)21-7-6-14(28)11-29-21)24(34)31-23-10-22(25(35)30-15-12-36-13-15)32-33(23)16-4-2-1-3-5-16/h1-11,15H,12-13H2,(H,30,35)(H,31,34) RLPFUVNEUWBEAS-UHFFFAOYSA-N 226746 US9328096, 439 High affinity nerve growth factor receptor [441-796] Human 37.1 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226746 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226746&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962897 336293847 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396483 O[C@H]1COCC[C@@H]1NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccc(F)cn2)n(n1)-c1ccccc1 InChI=1S/C27H22Cl2FN5O4/c28-19-11-20(29)18(10-17(19)21-7-6-15(30)13-31-21)26(37)33-25-12-23(34-35(25)16-4-2-1-3-5-16)27(38)32-22-8-9-39-14-24(22)36/h1-7,10-13,22,24,36H,8-9,14H2,(H,32,38)(H,33,37)/t22-,24-/m0/s1 BKLZAZXRPPXTAF-UPVQGACJSA-N 226747 US9328096, 440 High affinity nerve growth factor receptor [441-796] Human 26.2 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226747 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226747&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962898 336293848 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396484 CNC(=O)CNC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccc(F)cn2)n(n1)-c1ccccc1 InChI=1S/C25H19Cl2FN6O3/c1-29-23(35)13-31-25(37)21-11-22(34(33-21)15-5-3-2-4-6-15)32-24(36)17-9-16(18(26)10-19(17)27)20-8-7-14(28)12-30-20/h2-12H,13H2,1H3,(H,29,35)(H,31,37)(H,32,36) WZPWUZYNCXJBCZ-UHFFFAOYSA-N 226748 US9328096, 441 High affinity nerve growth factor receptor [441-796] Human 56.6 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226748 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226748&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962899 336293849 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396485 COC[C@@H](CO)NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccc(F)cn2)n(n1)-c1ccccc1 InChI=1S/C26H22Cl2FN5O4/c1-38-14-16(13-35)31-26(37)23-11-24(34(33-23)17-5-3-2-4-6-17)32-25(36)19-9-18(20(27)10-21(19)28)22-8-7-15(29)12-30-22/h2-12,16,35H,13-14H2,1H3,(H,31,37)(H,32,36)/t16-/m1/s1 QMXDNIDNQJQXQJ-MRXNPFEDSA-N 226749 US9328096, 442 High affinity nerve growth factor receptor [441-796] Human 50.4 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226749 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226749&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962900 336293850 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396486 O[C@H]1COC[C@@H]1NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccc(F)cn2)n(n1)-c1ccccc1 InChI=1S/C26H20Cl2FN5O4/c27-18-9-19(28)17(8-16(18)20-7-6-14(29)11-30-20)25(36)32-24-10-21(26(37)31-22-12-38-13-23(22)35)33-34(24)15-4-2-1-3-5-15/h1-11,22-23,35H,12-13H2,(H,31,37)(H,32,36)/t22-,23-/m0/s1 NGGOIVLXXLROKO-GOTSBHOMSA-N 226750 US9328096, 443 High affinity nerve growth factor receptor [441-796] Human 31.3 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226750 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226750&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962901 336293851 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396487 Cc1n[nH]cc1NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccc(F)cn2)n(n1)-c1ccccc1 InChI=1S/C26H18Cl2FN7O2/c1-14-23(13-31-34-14)32-26(38)22-11-24(36(35-22)16-5-3-2-4-6-16)33-25(37)18-9-17(19(27)10-20(18)28)21-8-7-15(29)12-30-21/h2-13H,1H3,(H,31,34)(H,32,38)(H,33,37) UFOJGDLGMSNGQX-UHFFFAOYSA-N 226751 US9328096, 444 High affinity nerve growth factor receptor [441-796] Human 4.75 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226751 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226751&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962902 336293852 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396488 Fc1ccc(nc1)-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)NCC2COC2)c(Cl)cc1Cl InChI=1S/C26H20Cl2FN5O3/c27-20-9-21(28)19(8-18(20)22-7-6-16(29)12-30-22)25(35)32-24-10-23(26(36)31-11-15-13-37-14-15)33-34(24)17-4-2-1-3-5-17/h1-10,12,15H,11,13-14H2,(H,31,36)(H,32,35) ZPUOSDLQLDSVJI-UHFFFAOYSA-N 226752 US9328096, 445 High affinity nerve growth factor receptor [441-796] Human 27.8 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226752 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226752&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962903 336293853 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396489 Cc1n[nH]c(C)c1NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccc(F)cn2)n(n1)-c1ccccc1 InChI=1S/C27H20Cl2FN7O2/c1-14-25(15(2)35-34-14)33-27(39)23-12-24(37(36-23)17-6-4-3-5-7-17)32-26(38)19-10-18(20(28)11-21(19)29)22-9-8-16(30)13-31-22/h3-13H,1-2H3,(H,32,38)(H,33,39)(H,34,35) ANBPJLHRSGKUOW-UHFFFAOYSA-N 226753 US9328096, 446 High affinity nerve growth factor receptor [441-796] Human 4.81 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226753 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226753&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962904 336293854 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396490 C[C@@H](O)CNC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccc(F)cn2)n(n1)-c1ccccc1 InChI=1S/C25H20Cl2FN5O3/c1-14(34)12-30-25(36)22-11-23(33(32-22)16-5-3-2-4-6-16)31-24(35)18-9-17(19(26)10-20(18)27)21-8-7-15(28)13-29-21/h2-11,13-14,34H,12H2,1H3,(H,30,36)(H,31,35)/t14-/m1/s1 KFWNJJFKCVAODX-CQSZACIVSA-N 226754 US9328096, 447 High affinity nerve growth factor receptor [441-796] Human 36.5 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226754 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226754&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962905 336293855 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396491 Fc1ccc(nc1)-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)N2CCNC(=O)C2)c(Cl)cc1Cl InChI=1S/C26H19Cl2FN6O3/c27-19-11-20(28)18(10-17(19)21-7-6-15(29)13-31-21)25(37)32-23-12-22(26(38)34-9-8-30-24(36)14-34)33-35(23)16-4-2-1-3-5-16/h1-7,10-13H,8-9,14H2,(H,30,36)(H,32,37) WLAZSYLHPQVPKH-UHFFFAOYSA-N 226755 US9328096, 448 High affinity nerve growth factor receptor [441-796] Human 74.9 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226755 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226755&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962906 336293856 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396492 NC(=O)CNC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccc(F)cn2)n(n1)-c1ccccc1 InChI=1S/C24H17Cl2FN6O3/c25-17-9-18(26)16(8-15(17)19-7-6-13(27)11-29-19)23(35)31-22-10-20(24(36)30-12-21(28)34)32-33(22)14-4-2-1-3-5-14/h1-11H,12H2,(H2,28,34)(H,30,36)(H,31,35) KVRMIHAPDKYOIT-UHFFFAOYSA-N 226756 US9328096, 449 High affinity nerve growth factor receptor [441-796] Human 64.1 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226756 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226756&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962907 336293857 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396493 OC[C@H](O)CNC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccc(F)cn2)n(n1)-c1ccccc1 InChI=1S/C25H20Cl2FN5O4/c26-19-9-20(27)18(8-17(19)21-7-6-14(28)11-29-21)24(36)31-23-10-22(25(37)30-12-16(35)13-34)32-33(23)15-4-2-1-3-5-15/h1-11,16,34-35H,12-13H2,(H,30,37)(H,31,36)/t16-/m1/s1 LTPPTYBHHCTXJS-MRXNPFEDSA-N 226757 US9328096, 450 High affinity nerve growth factor receptor [441-796] Human 46.7 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226757 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226757&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962908 336293858 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396494 Cn1cc(CNC(=O)c2cc(NC(=O)c3cc(c(Cl)cc3Cl)-c3ccc(F)cn3)n(n2)-c2ccccc2)nn1 InChI=1S/C26H19Cl2FN8O2/c1-36-14-16(33-35-36)13-31-26(39)23-11-24(37(34-23)17-5-3-2-4-6-17)32-25(38)19-9-18(20(27)10-21(19)28)22-8-7-15(29)12-30-22/h2-12,14H,13H2,1H3,(H,31,39)(H,32,38) SZETXNOSZQFMON-UHFFFAOYSA-N 226758 US9328096, 451 High affinity nerve growth factor receptor [441-796] Human 17.2 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226758 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226758&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962909 336293859 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396495 Nc1cc(CNC(=O)c2cc(NC(=O)c3cc(c(Cl)cc3Cl)-c3ccc(F)cn3)n(n2)-c2ccccc2)ccn1 InChI=1S/C28H20Cl2FN7O2/c29-21-12-22(30)20(11-19(21)23-7-6-17(31)15-34-23)27(39)36-26-13-24(37-38(26)18-4-2-1-3-5-18)28(40)35-14-16-8-9-33-25(32)10-16/h1-13,15H,14H2,(H2,32,33)(H,35,40)(H,36,39) KXURWBDZXKSKIF-UHFFFAOYSA-N 226759 US9328096, 452 High affinity nerve growth factor receptor [441-796] Human 1.43 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226759 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226759&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962910 336293860 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396496 O[C@H]1CC[C@H](CC1)NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccc(F)cn2)n(n1)-c1ccccc1 InChI=1S/C28H24Cl2FN5O3/c29-22-13-23(30)21(12-20(22)24-11-6-16(31)15-32-24)27(38)34-26-14-25(35-36(26)18-4-2-1-3-5-18)28(39)33-17-7-9-19(37)10-8-17/h1-6,11-15,17,19,37H,7-10H2,(H,33,39)(H,34,38)/t17-,19+ SMJITQLMIQDIPJ-IZAXUBKRSA-N 226760 US9328096, 453 High affinity nerve growth factor receptor [441-796] Human 22 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226760 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226760&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962911 336293861 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396497 Fc1ccc(nc1)-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)NCC2CCC(=O)N2)c(Cl)cc1Cl InChI=1S/C27H21Cl2FN6O3/c28-20-11-21(29)19(10-18(20)22-8-6-15(30)13-31-22)26(38)34-24-12-23(35-36(24)17-4-2-1-3-5-17)27(39)32-14-16-7-9-25(37)33-16/h1-6,8,10-13,16H,7,9,14H2,(H,32,39)(H,33,37)(H,34,38) LQJRYNRVZCWEED-UHFFFAOYSA-N 226761 US9328096, 454 High affinity nerve growth factor receptor [441-796] Human 116 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226761 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226761&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962912 336293862 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396498 CC(C)(O)CNC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccc(F)cn2)n(n1)-c1ccccc1 InChI=1S/C26H22Cl2FN5O3/c1-26(2,37)14-31-25(36)22-12-23(34(33-22)16-6-4-3-5-7-16)32-24(35)18-10-17(19(27)11-20(18)28)21-9-8-15(29)13-30-21/h3-13,37H,14H2,1-2H3,(H,31,36)(H,32,35) LYOFHUBUFFYNCY-UHFFFAOYSA-N 226762 US9328096, 455 High affinity nerve growth factor receptor [441-796] Human 38.2 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226762 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226762&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962913 336293863 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396499 OCCOCCNC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccc(F)cn2)n(n1)-c1ccccc1 InChI=1S/C26H22Cl2FN5O4/c27-20-13-21(28)19(12-18(20)22-7-6-16(29)15-31-22)25(36)32-24-14-23(26(37)30-8-10-38-11-9-35)33-34(24)17-4-2-1-3-5-17/h1-7,12-15,35H,8-11H2,(H,30,37)(H,32,36) ZQYRGFZXBCVBHY-UHFFFAOYSA-N 226763 US9328096, 456 High affinity nerve growth factor receptor [441-796] Human 38.6 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226763 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226763&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962914 336293864 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396500 Fc1ccc(nc1)-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)NCc2ncccn2)c(Cl)cc1Cl InChI=1S/C27H18Cl2FN7O2/c28-20-12-21(29)19(11-18(20)22-8-7-16(30)14-33-22)26(38)35-25-13-23(36-37(25)17-5-2-1-3-6-17)27(39)34-15-24-31-9-4-10-32-24/h1-14H,15H2,(H,34,39)(H,35,38) ATDFTWVJHPMKFE-UHFFFAOYSA-N 226764 US9328096, 457 High affinity nerve growth factor receptor [441-796] Human 51.3 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226764 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226764&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962915 336293865 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396501 NC(=O)[C@H]1CCCN(C1)C(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccc(F)cn2)n(n1)-c1ccccc1 InChI=1S/C28H23Cl2FN6O3/c29-21-12-22(30)20(11-19(21)23-9-8-17(31)14-33-23)27(39)34-25-13-24(35-37(25)18-6-2-1-3-7-18)28(40)36-10-4-5-16(15-36)26(32)38/h1-3,6-9,11-14,16H,4-5,10,15H2,(H2,32,38)(H,34,39)/t16-/m0/s1 CJGOZASHXNCEDC-INIZCTEOSA-N 226765 US9328096, 458 High affinity nerve growth factor receptor [441-796] Human 59.9 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226765 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226765&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962916 336293866 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396502 CN1CC(C1)NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccc(F)cn2)n(n1)-c1ccccc1 InChI=1S/C26H21Cl2FN6O2/c1-34-13-16(14-34)31-26(37)23-11-24(35(33-23)17-5-3-2-4-6-17)32-25(36)19-9-18(20(27)10-21(19)28)22-8-7-15(29)12-30-22/h2-12,16H,13-14H2,1H3,(H,31,37)(H,32,36) YZHYTNCXMBOVKO-UHFFFAOYSA-N 226766 US9328096, 459 High affinity nerve growth factor receptor [441-796] Human 98.3 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226766 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226766&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962917 336293867 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396503 O[C@H]1C[C@H](C1)NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccc(F)cn2)n(n1)-c1ccccc1 InChI=1S/C26H20Cl2FN5O3/c27-20-11-21(28)19(10-18(20)22-7-6-14(29)13-30-22)25(36)32-24-12-23(26(37)31-15-8-17(35)9-15)33-34(24)16-4-2-1-3-5-16/h1-7,10-13,15,17,35H,8-9H2,(H,31,37)(H,32,36)/t15-,17+ FHSJMWLGNXPIHR-WOVMCDHWSA-N 226767 US9328096, 460 High affinity nerve growth factor receptor [441-796] Human 25.2 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226767 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226767&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962918 336293868 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396504 CNC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccc(F)cn2)n(n1)-c1ccccc1 InChI=1S/C23H16Cl2FN5O2/c1-27-23(33)20-11-21(31(30-20)14-5-3-2-4-6-14)29-22(32)16-9-15(17(24)10-18(16)25)19-8-7-13(26)12-28-19/h2-12H,1H3,(H,27,33)(H,29,32) BTPRYTIIAWDSEV-UHFFFAOYSA-N 226768 US9328096, 461 High affinity nerve growth factor receptor [441-796] Human 20.7 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226768 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226768&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962919 336293869 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396505 OC1CN(C1)C(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccc(F)cn2)n(n1)-c1ccccc1 InChI=1S/C25H18Cl2FN5O3/c26-19-9-20(27)18(8-17(19)21-7-6-14(28)11-29-21)24(35)30-23-10-22(25(36)32-12-16(34)13-32)31-33(23)15-4-2-1-3-5-15/h1-11,16,34H,12-13H2,(H,30,35) WBMVISBXHPKQEO-UHFFFAOYSA-N 226769 US9328096, 462 High affinity nerve growth factor receptor [441-796] Human 55.5 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226769 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226769&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962920 336293870 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396506 O[C@@H]1COC[C@H]1NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccc(F)cn2)n(n1)-c1ccccc1 InChI=1S/C26H20Cl2FN5O4/c27-18-9-19(28)17(8-16(18)20-7-6-14(29)11-30-20)25(36)32-24-10-21(26(37)31-22-12-38-13-23(22)35)33-34(24)15-4-2-1-3-5-15/h1-11,22-23,35H,12-13H2,(H,31,37)(H,32,36)/t22-,23-/m1/s1 NGGOIVLXXLROKO-DHIUTWEWSA-N 226770 US9328096, 463 High affinity nerve growth factor receptor [441-796] Human 31.8 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226770 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226770&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962921 336293871 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396507 Fc1ccc(nc1)-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)NCc2ccno2)c(Cl)cc1Cl InChI=1S/C26H17Cl2FN6O3/c27-20-11-21(28)19(10-18(20)22-7-6-15(29)13-30-22)25(36)33-24-12-23(26(37)31-14-17-8-9-32-38-17)34-35(24)16-4-2-1-3-5-16/h1-13H,14H2,(H,31,37)(H,33,36) QHUANRQBVNDKEO-UHFFFAOYSA-N 226771 US9328096, 464 High affinity nerve growth factor receptor [441-796] Human 13.2 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226771 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226771&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962922 336293872 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396508 Fc1ccc(nc1)-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)N[C@@H]2CNC(=O)C2)c(Cl)cc1Cl InChI=1S/C26H19Cl2FN6O3/c27-19-10-20(28)18(9-17(19)21-7-6-14(29)12-30-21)25(37)33-23-11-22(26(38)32-15-8-24(36)31-13-15)34-35(23)16-4-2-1-3-5-16/h1-7,9-12,15H,8,13H2,(H,31,36)(H,32,38)(H,33,37)/t15-/m0/s1 LSUIRSZWVXXJAY-HNNXBMFYSA-N 226772 US9328096, 465 High affinity nerve growth factor receptor [441-796] Human 178 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226772 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226772&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962923 336293873 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396509 Cc1n[nH]c(CNC(=O)c2cc(NC(=O)c3cc(c(Cl)cc3Cl)-c3ccc(F)cn3)n(n2)-c2ccccc2)n1 InChI=1S/C26H19Cl2FN8O2/c1-14-32-23(35-34-14)13-31-26(39)22-11-24(37(36-22)16-5-3-2-4-6-16)33-25(38)18-9-17(19(27)10-20(18)28)21-8-7-15(29)12-30-21/h2-12H,13H2,1H3,(H,31,39)(H,33,38)(H,32,34,35) PTVICNDDOQMDAG-UHFFFAOYSA-N 226773 US9328096, 466 High affinity nerve growth factor receptor [441-796] Human 30.8 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226773 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226773&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962924 336293874 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396510 O[C@H]1CC[C@@H](CC1)NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccc(F)cn2)n(n1)-c1ccccc1 InChI=1S/C28H24Cl2FN5O3/c29-22-13-23(30)21(12-20(22)24-11-6-16(31)15-32-24)27(38)34-26-14-25(35-36(26)18-4-2-1-3-5-18)28(39)33-17-7-9-19(37)10-8-17/h1-6,11-15,17,19,37H,7-10H2,(H,33,39)(H,34,38)/t17-,19- SMJITQLMIQDIPJ-UAPYVXQJSA-N 226774 US9328096, 467 High affinity nerve growth factor receptor [441-796] Human 17.4 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226774 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226774&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962911 336293875 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396511 C[C@H](CO)NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccc(F)cn2)n(n1)-c1ccccc1 InChI=1S/C25H20Cl2FN5O3/c1-14(13-34)30-25(36)22-11-23(33(32-22)16-5-3-2-4-6-16)31-24(35)18-9-17(19(26)10-20(18)27)21-8-7-15(28)12-29-21/h2-12,14,34H,13H2,1H3,(H,30,36)(H,31,35)/t14-/m1/s1 QSYMOHRZVOTNKG-CQSZACIVSA-N 226775 US9328096, 468 High affinity nerve growth factor receptor [441-796] Human 28.5 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226775 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226775&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962925 336293876 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396512 Fc1ccc(nc1)-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)NCc2cccnn2)c(Cl)cc1Cl InChI=1S/C27H18Cl2FN7O2/c28-21-12-22(29)20(11-19(21)23-9-8-16(30)14-31-23)26(38)34-25-13-24(36-37(25)18-6-2-1-3-7-18)27(39)32-15-17-5-4-10-33-35-17/h1-14H,15H2,(H,32,39)(H,34,38) CLSWIEZMAKFMKI-UHFFFAOYSA-N 226776 US9328096, 469 High affinity nerve growth factor receptor [441-796] Human 30.9 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226776 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226776&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962926 336293877 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396513 CC1(COC1)NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccc(F)cn2)n(n1)-c1ccccc1 InChI=1S/C26H20Cl2FN5O3/c1-26(13-37-14-26)32-25(36)22-11-23(34(33-22)16-5-3-2-4-6-16)31-24(35)18-9-17(19(27)10-20(18)28)21-8-7-15(29)12-30-21/h2-12H,13-14H2,1H3,(H,31,35)(H,32,36) IZYJTRZXYDYCCS-UHFFFAOYSA-N 226777 US9328096, 470 High affinity nerve growth factor receptor [441-796] Human 32.7 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226777 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226777&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962927 336293878 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396514 Fc1ccc(nc1)-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)NCc2cnco2)c(Cl)cc1Cl InChI=1S/C26H17Cl2FN6O3/c27-20-9-21(28)19(8-18(20)22-7-6-15(29)11-31-22)25(36)33-24-10-23(26(37)32-13-17-12-30-14-38-17)34-35(24)16-4-2-1-3-5-16/h1-12,14H,13H2,(H,32,37)(H,33,36) WZGBXXNLZCHWIE-UHFFFAOYSA-N 226778 US9328096, 471 High affinity nerve growth factor receptor [441-796] Human 17.9 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226778 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226778&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962928 336293879 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396515 NC(=O)C1CCN(C1)C(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccc(F)cn2)n(n1)-c1ccccc1 InChI=1S/C27H21Cl2FN6O3/c28-20-11-21(29)19(10-18(20)22-7-6-16(30)13-32-22)26(38)33-24-12-23(34-36(24)17-4-2-1-3-5-17)27(39)35-9-8-15(14-35)25(31)37/h1-7,10-13,15H,8-9,14H2,(H2,31,37)(H,33,38) CTPSEKHBQOJJJN-UHFFFAOYSA-N 226779 US9328096, 472 High affinity nerve growth factor receptor [441-796] Human 189 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226779 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226779&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962929 336293880 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396516 Fc1ccc(nc1)-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)NCc2ccncn2)c(Cl)cc1Cl InChI=1S/C27H18Cl2FN7O2/c28-21-11-22(29)20(10-19(21)23-7-6-16(30)13-32-23)26(38)35-25-12-24(36-37(25)18-4-2-1-3-5-18)27(39)33-14-17-8-9-31-15-34-17/h1-13,15H,14H2,(H,33,39)(H,35,38) DOYKBQDHWIEHTG-UHFFFAOYSA-N 226780 US9328096, 473 High affinity nerve growth factor receptor [441-796] Human 24.7 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226780 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226780&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962930 336293881 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396517 Fc1ccc(nc1)-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)N[C@@H]2CCOC2)c(Cl)cc1Cl InChI=1S/C26H20Cl2FN5O3/c27-20-11-21(28)19(10-18(20)22-7-6-15(29)13-30-22)25(35)32-24-12-23(26(36)31-16-8-9-37-14-16)33-34(24)17-4-2-1-3-5-17/h1-7,10-13,16H,8-9,14H2,(H,31,36)(H,32,35)/t16-/m1/s1 JNFMIYGKYOMTHP-MRXNPFEDSA-N 226781 US9328096, 474 High affinity nerve growth factor receptor [441-796] Human 24.2 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226781 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226781&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962931 336293882 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396518 COCCNC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccc(F)cn2)n(n1)-c1ccccc1 InChI=1S/C25H20Cl2FN5O3/c1-36-10-9-29-25(35)22-13-23(33(32-22)16-5-3-2-4-6-16)31-24(34)18-11-17(19(26)12-20(18)27)21-8-7-15(28)14-30-21/h2-8,11-14H,9-10H2,1H3,(H,29,35)(H,31,34) YKQYWLNRAFNADE-UHFFFAOYSA-N 226782 US9328096, 475 High affinity nerve growth factor receptor [441-796] Human 34.6 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226782 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226782&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962932 336293883 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396519 OCCCNC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccc(F)cn2)n(n1)-c1ccccc1 InChI=1S/C25H20Cl2FN5O3/c26-19-12-20(27)18(11-17(19)21-8-7-15(28)14-30-21)24(35)31-23-13-22(25(36)29-9-4-10-34)32-33(23)16-5-2-1-3-6-16/h1-3,5-8,11-14,34H,4,9-10H2,(H,29,36)(H,31,35) HZPKMVGGXWGYBY-UHFFFAOYSA-N 226783 US9328096, 476 High affinity nerve growth factor receptor [441-796] Human 13.7 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226783 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226783&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962933 336293884 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396520 OC1(CNC(=O)c2cc(NC(=O)c3cc(c(Cl)cc3Cl)-c3ccc(F)cn3)n(n2)-c2ccccc2)CC1 InChI=1S/C26H20Cl2FN5O3/c27-19-11-20(28)18(10-17(19)21-7-6-15(29)13-30-21)24(35)32-23-12-22(25(36)31-14-26(37)8-9-26)33-34(23)16-4-2-1-3-5-16/h1-7,10-13,37H,8-9,14H2,(H,31,36)(H,32,35) RMXHFIVJGZGEPJ-UHFFFAOYSA-N 226784 US9328096, 477 High affinity nerve growth factor receptor [441-796] Human 41.7 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226784 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226784&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962934 336293885 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396521 C[C@H](O)CNC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccc(F)cn2)n(n1)-c1ccccc1 InChI=1S/C25H20Cl2FN5O3/c1-14(34)12-30-25(36)22-11-23(33(32-22)16-5-3-2-4-6-16)31-24(35)18-9-17(19(26)10-20(18)27)21-8-7-15(28)13-29-21/h2-11,13-14,34H,12H2,1H3,(H,30,36)(H,31,35)/t14-/m0/s1 KFWNJJFKCVAODX-AWEZNQCLSA-N 226785 US9328096, 478 High affinity nerve growth factor receptor [441-796] Human 28.6 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226785 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226785&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962935 336293886 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396522 O[C@H]1C[C@@H](C1)NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccc(F)cn2)n(n1)-c1ccccc1 InChI=1S/C26H20Cl2FN5O3/c27-20-11-21(28)19(10-18(20)22-7-6-14(29)13-30-22)25(36)32-24-12-23(26(37)31-15-8-17(35)9-15)33-34(24)16-4-2-1-3-5-16/h1-7,10-13,15,17,35H,8-9H2,(H,31,37)(H,32,36)/t15-,17- FHSJMWLGNXPIHR-JCNLHEQBSA-N 226786 US9328096, 479 High affinity nerve growth factor receptor [441-796] Human 24.2 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226786 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226786&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962918 336293887 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396523 C[C@@H](CO)NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccc(F)cn2)n(n1)-c1ccccc1 InChI=1S/C25H20Cl2FN5O3/c1-14(13-34)30-25(36)22-11-23(33(32-22)16-5-3-2-4-6-16)31-24(35)18-9-17(19(26)10-20(18)27)21-8-7-15(28)12-29-21/h2-12,14,34H,13H2,1H3,(H,30,36)(H,31,35)/t14-/m0/s1 QSYMOHRZVOTNKG-AWEZNQCLSA-N 226787 US9328096, 480 High affinity nerve growth factor receptor [441-796] Human 32.5 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226787 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226787&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962936 336293888 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396524 Fc1cccnc1-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)NCc2ccccn2)c(Cl)cc1F InChI=1S/C28H19ClF2N6O2/c29-21-14-23(31)20(26-22(30)10-6-12-33-26)13-19(21)27(38)35-25-15-24(36-37(25)18-8-2-1-3-9-18)28(39)34-16-17-7-4-5-11-32-17/h1-15H,16H2,(H,34,39)(H,35,38) IABUWSMQTLSBPT-UHFFFAOYSA-N 226788 US9328096, 481 High affinity nerve growth factor receptor [441-796] Human 17 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226788 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226788&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962937 336293889 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396525 Fc1cccnc1-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)NCC2CCC(=O)N2)c(Cl)cc1F InChI=1S/C27H21ClF2N6O3/c28-19-12-21(30)18(25-20(29)7-4-10-31-25)11-17(19)26(38)34-23-13-22(35-36(23)16-5-2-1-3-6-16)27(39)32-14-15-8-9-24(37)33-15/h1-7,10-13,15H,8-9,14H2,(H,32,39)(H,33,37)(H,34,38) NHXVXNFLCOLBAI-UHFFFAOYSA-N 226789 US9328096, 482 High affinity nerve growth factor receptor [441-796] Human 44 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226789 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226789&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962938 336293890 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396526 Fc1cc(Cl)c(cc1-c1ncccc1F)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)N1CCNC(=O)C1 InChI=1S/C26H19ClF2N6O3/c27-18-12-20(29)17(24-19(28)7-4-8-31-24)11-16(18)25(37)32-22-13-21(26(38)34-10-9-30-23(36)14-34)33-35(22)15-5-2-1-3-6-15/h1-8,11-13H,9-10,14H2,(H,30,36)(H,32,37) VNCDDQFMHRGNOH-UHFFFAOYSA-N 226790 US9328096, 483 High affinity nerve growth factor receptor [441-796] Human 34.9 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226790 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226790&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962939 336293891 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396527 COCC(O)CNC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C26H22ClF2N5O4/c1-38-14-16(35)13-31-26(37)22-12-23(34(33-22)15-6-3-2-4-7-15)32-25(36)17-10-18(21(29)11-19(17)27)24-20(28)8-5-9-30-24/h2-12,16,35H,13-14H2,1H3,(H,31,37)(H,32,36) YMCKKWNWOZFNMH-UHFFFAOYSA-N 226791 US9328096, 484 High affinity nerve growth factor receptor [441-796] Human 23.1 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226791 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226791&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962940 336293892 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396528 Fc1cc(Cl)c(cc1-c1ncccc1F)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCc1ccncn1 InChI=1S/C27H18ClF2N7O2/c28-20-12-22(30)19(25-21(29)7-4-9-32-25)11-18(20)26(38)35-24-13-23(36-37(24)17-5-2-1-3-6-17)27(39)33-14-16-8-10-31-15-34-16/h1-13,15H,14H2,(H,33,39)(H,35,38) PFGDBJCCAKUDGR-UHFFFAOYSA-N 226792 US9328096, 485 High affinity nerve growth factor receptor [441-796] Human 10.2 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226792 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226792&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962941 336293893 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396529 Fc1cc(Cl)c(cc1-c1ncccc1F)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCC1CCOC1 InChI=1S/C27H22ClF2N5O3/c28-20-12-22(30)19(25-21(29)7-4-9-31-25)11-18(20)26(36)33-24-13-23(27(37)32-14-16-8-10-38-15-16)34-35(24)17-5-2-1-3-6-17/h1-7,9,11-13,16H,8,10,14-15H2,(H,32,37)(H,33,36) ONDJTKHHUWJGLC-UHFFFAOYSA-N 226793 US9328096, 486 High affinity nerve growth factor receptor [441-796] Human 11.8 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226793 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226793&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962942 336293894 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396530 Fc1cc(Cl)c(cc1-c1ncccc1F)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)N[C@@H]1CNC(=O)C1 InChI=1S/C26H19ClF2N6O3/c27-18-11-20(29)17(24-19(28)7-4-8-30-24)10-16(18)25(37)33-22-12-21(26(38)32-14-9-23(36)31-13-14)34-35(22)15-5-2-1-3-6-15/h1-8,10-12,14H,9,13H2,(H,31,36)(H,32,38)(H,33,37)/t14-/m0/s1 WEGQMPKYKKKEQE-AWEZNQCLSA-N 226794 US9328096, 487 High affinity nerve growth factor receptor [441-796] Human 98.8 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226794 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226794&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962943 336293895 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396531 CN1CCC(C1)NC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C27H23ClF2N6O2/c1-35-11-9-16(15-35)32-27(38)23-14-24(36(34-23)17-6-3-2-4-7-17)33-26(37)18-12-19(22(30)13-20(18)28)25-21(29)8-5-10-31-25/h2-8,10,12-14,16H,9,11,15H2,1H3,(H,32,38)(H,33,37) RKVXMCYRPRINPI-UHFFFAOYSA-N 226795 US9328096, 488 High affinity nerve growth factor receptor [441-796] Human 33.1 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226795 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226795&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962944 336293896 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396532 Cn1cc(CNC(=O)c2cc(NC(=O)c3cc(c(F)cc3Cl)-c3ncccc3F)n(n2)-c2ccccc2)nn1 InChI=1S/C26H19ClF2N8O2/c1-36-14-15(33-35-36)13-31-26(39)22-12-23(37(34-22)16-6-3-2-4-7-16)32-25(38)17-10-18(21(29)11-19(17)27)24-20(28)8-5-9-30-24/h2-12,14H,13H2,1H3,(H,31,39)(H,32,38) NGOQOGUFJPNMLV-UHFFFAOYSA-N 226796 US9328096, 489 High affinity nerve growth factor receptor [441-796] Human 7.26 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226796 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226796&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962945 336293897 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396533 Fc1cc(Cl)c(cc1-c1ncccc1F)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCc1nnc[nH]1 InChI=1S/C25H17ClF2N8O2/c26-17-10-19(28)16(23-18(27)7-4-8-29-23)9-15(17)24(37)33-22-11-20(25(38)30-12-21-31-13-32-34-21)35-36(22)14-5-2-1-3-6-14/h1-11,13H,12H2,(H,30,38)(H,33,37)(H,31,32,34) INMBRLJLHAJWRO-UHFFFAOYSA-N 226797 US9328096, 490 High affinity nerve growth factor receptor [441-796] Human 44.9 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226797 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226797&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962946 336293898 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396534 CN1CC(C1)NC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C26H21ClF2N6O2/c1-34-13-15(14-34)31-26(37)22-12-23(35(33-22)16-6-3-2-4-7-16)32-25(36)17-10-18(21(29)11-19(17)27)24-20(28)8-5-9-30-24/h2-12,15H,13-14H2,1H3,(H,31,37)(H,32,36) XTISKACKRWGPPW-UHFFFAOYSA-N 226798 US9328096, 491 High affinity nerve growth factor receptor [441-796] Human 41.2 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226798 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226798&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962947 336293899 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396535 NC(=O)[C@H]1CCCN(C1)C(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C28H23ClF2N6O3/c29-20-13-22(31)19(25-21(30)9-4-10-33-25)12-18(20)27(39)34-24-14-23(35-37(24)17-7-2-1-3-8-17)28(40)36-11-5-6-16(15-36)26(32)38/h1-4,7-10,12-14,16H,5-6,11,15H2,(H2,32,38)(H,34,39)/t16-/m0/s1 GGQFSLIGWDHLEG-INIZCTEOSA-N 226799 US9328096, 492 High affinity nerve growth factor receptor [441-796] Human 24.6 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226799 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226799&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962948 336293900 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396536 Fc1cccnc1-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)NC2CCOCC2)c(Cl)cc1F InChI=1S/C27H22ClF2N5O3/c28-20-14-22(30)19(25-21(29)7-4-10-31-25)13-18(20)26(36)33-24-15-23(27(37)32-16-8-11-38-12-9-16)34-35(24)17-5-2-1-3-6-17/h1-7,10,13-16H,8-9,11-12H2,(H,32,37)(H,33,36) UCCUCYGLMNAPCJ-UHFFFAOYSA-N 226800 US9328096, 493 High affinity nerve growth factor receptor [441-796] Human 14.5 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226800 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226800&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962949 336293901 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396537 OCC1(CNC(=O)c2cc(NC(=O)c3cc(c(F)cc3Cl)-c3ncccc3F)n(n2)-c2ccccc2)COC1 InChI=1S/C27H22ClF2N5O4/c28-19-10-21(30)18(24-20(29)7-4-8-31-24)9-17(19)25(37)33-23-11-22(34-35(23)16-5-2-1-3-6-16)26(38)32-12-27(13-36)14-39-15-27/h1-11,36H,12-15H2,(H,32,38)(H,33,37) JBRCURFNQWKKCX-UHFFFAOYSA-N 226801 US9328096, 494 High affinity nerve growth factor receptor [441-796] Human 15.1 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226801 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226801&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962950 336293902 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396538 Fc1cc(Cl)c(cc1-c1ncccc1F)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCc1cocn1 InChI=1S/C26H17ClF2N6O3/c27-19-10-21(29)18(24-20(28)7-4-8-30-24)9-17(19)25(36)33-23-11-22(26(37)31-12-15-13-38-14-32-15)34-35(23)16-5-2-1-3-6-16/h1-11,13-14H,12H2,(H,31,37)(H,33,36) IBTOLBBWUCDVJN-UHFFFAOYSA-N 226802 US9328096, 495 High affinity nerve growth factor receptor [441-796] Human 12.4 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226802 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226802&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962951 336293903 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396539 CC(C)(O)CCNC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C27H24ClF2N5O3/c1-27(2,38)10-12-32-26(37)22-15-23(35(34-22)16-7-4-3-5-8-16)33-25(36)17-13-18(21(30)14-19(17)28)24-20(29)9-6-11-31-24/h3-9,11,13-15,38H,10,12H2,1-2H3,(H,32,37)(H,33,36) BPEAYYOTQXAKQF-UHFFFAOYSA-N 226803 US9328096, 496 High affinity nerve growth factor receptor [441-796] Human 18.1 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226803 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226803&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962952 336293904 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396540 COC[C@H](CO)NC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C26H22ClF2N5O4/c1-38-14-15(13-35)31-26(37)22-12-23(34(33-22)16-6-3-2-4-7-16)32-25(36)17-10-18(21(29)11-19(17)27)24-20(28)8-5-9-30-24/h2-12,15,35H,13-14H2,1H3,(H,31,37)(H,32,36)/t15-/m0/s1 LCQMXQLWMVDDRR-HNNXBMFYSA-N 226804 US9328096, 497 High affinity nerve growth factor receptor [441-796] Human 23.7 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226804 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226804&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962953 336293905 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396541 CN(C)C(=O)CNC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C26H21ClF2N6O3/c1-34(2)23(36)14-31-26(38)21-13-22(35(33-21)15-7-4-3-5-8-15)32-25(37)16-11-17(20(29)12-18(16)27)24-19(28)9-6-10-30-24/h3-13H,14H2,1-2H3,(H,31,38)(H,32,37) VPEPRDPDWOQUDK-UHFFFAOYSA-N 226805 US9328096, 498 High affinity nerve growth factor receptor [441-796] Human 46.6 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226805 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226805&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962954 336293906 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396542 OCCC1(COC1)NC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C27H22ClF2N5O4/c28-19-12-21(30)18(24-20(29)7-4-9-31-24)11-17(19)25(37)32-23-13-22(34-35(23)16-5-2-1-3-6-16)26(38)33-27(8-10-36)14-39-15-27/h1-7,9,11-13,36H,8,10,14-15H2,(H,32,37)(H,33,38) UDSRTLCZFJLBNT-UHFFFAOYSA-N 226806 US9328096, 499 High affinity nerve growth factor receptor [441-796] Human 15.8 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226806 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226806&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962955 336293907 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396543 Cc1n[nH]c(C)c1NC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C27H20ClF2N7O2/c1-14-24(15(2)35-34-14)33-27(39)22-13-23(37(36-22)16-7-4-3-5-8-16)32-26(38)17-11-18(21(30)12-19(17)28)25-20(29)9-6-10-31-25/h3-13H,1-2H3,(H,32,38)(H,33,39)(H,34,35) IIUZGUUHINVRCV-UHFFFAOYSA-N 226807 US9328096, 500 High affinity nerve growth factor receptor [441-796] Human 2.84 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226807 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226807&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962956 336293908 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396544 Fc1cc(Cl)c(cc1-c1ncccc1F)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCCn1ccnn1 InChI=1S/C26H19ClF2N8O2/c27-19-14-21(29)18(24-20(28)7-4-8-30-24)13-17(19)25(38)33-23-15-22(34-37(23)16-5-2-1-3-6-16)26(39)31-9-11-36-12-10-32-35-36/h1-8,10,12-15H,9,11H2,(H,31,39)(H,33,38) LSVYVZADIWJFNT-UHFFFAOYSA-N 226808 US9328096, 501 High affinity nerve growth factor receptor [441-796] Human 15.7 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226808 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226808&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962957 336293909 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396545 Fc1cccnc1-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)NC2CC2)c(Cl)cc1F InChI=1S/C25H18ClF2N5O2/c26-18-12-20(28)17(23-19(27)7-4-10-29-23)11-16(18)24(34)31-22-13-21(25(35)30-14-8-9-14)32-33(22)15-5-2-1-3-6-15/h1-7,10-14H,8-9H2,(H,30,35)(H,31,34) QVSMQZMHIBITNP-UHFFFAOYSA-N 226809 US9328096, 502 High affinity nerve growth factor receptor [441-796] Human 8.87 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226809 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226809&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962958 336293910 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396546 Fc1cccnc1-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)NCc2ncccn2)c(Cl)cc1F InChI=1S/C27H18ClF2N7O2/c28-19-13-21(30)18(25-20(29)8-4-9-33-25)12-17(19)26(38)35-24-14-22(36-37(24)16-6-2-1-3-7-16)27(39)34-15-23-31-10-5-11-32-23/h1-14H,15H2,(H,34,39)(H,35,38) UBGYJQDQKZGCBE-UHFFFAOYSA-N 226810 US9328096, 503 High affinity nerve growth factor receptor [441-796] Human 26.7 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226810 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226810&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962959 336293911 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396547 OCC1(COC1)NC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C26H20ClF2N5O4/c27-18-10-20(29)17(23-19(28)7-4-8-30-23)9-16(18)24(36)31-22-11-21(25(37)32-26(12-35)13-38-14-26)33-34(22)15-5-2-1-3-6-15/h1-11,35H,12-14H2,(H,31,36)(H,32,37) AUKIIIKVZRRXHA-UHFFFAOYSA-N 226811 US9328096, 504 High affinity nerve growth factor receptor [441-796] Human 20.9 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226811 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226811&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962960 336293912 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396548 Cn1cc(CNC(=O)c2cc(NC(=O)c3cc(c(F)cc3Cl)-c3ncccc3F)n(n2)-c2ccccc2)cn1 InChI=1S/C27H20ClF2N7O2/c1-36-15-16(14-33-36)13-32-27(39)23-12-24(37(35-23)17-6-3-2-4-7-17)34-26(38)18-10-19(22(30)11-20(18)28)25-21(29)8-5-9-31-25/h2-12,14-15H,13H2,1H3,(H,32,39)(H,34,38) YFNDDELGLKEMID-UHFFFAOYSA-N 226812 US9328096, 505 High affinity nerve growth factor receptor [441-796] Human 12 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226812 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226812&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962961 336293913 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396549 CNC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C23H16ClF2N5O2/c1-27-23(33)19-12-20(31(30-19)13-6-3-2-4-7-13)29-22(32)14-10-15(18(26)11-16(14)24)21-17(25)8-5-9-28-21/h2-12H,1H3,(H,27,33)(H,29,32) FJHYLTBENGDRDW-UHFFFAOYSA-N 226813 US9328096, 506 High affinity nerve growth factor receptor [441-796] Human 14.2 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226813 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226813&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962962 336293914 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396550 OCCOCCNC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C26H22ClF2N5O4/c27-19-14-21(29)18(24-20(28)7-4-8-30-24)13-17(19)25(36)32-23-15-22(26(37)31-9-11-38-12-10-35)33-34(23)16-5-2-1-3-6-16/h1-8,13-15,35H,9-12H2,(H,31,37)(H,32,36) GWEPOOIDXDBLAI-UHFFFAOYSA-N 226814 US9328096, 507 High affinity nerve growth factor receptor [441-796] Human 25.6 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226814 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226814&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962963 336293915 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396551 O[C@@H]1COCC[C@H]1NC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C27H22ClF2N5O4/c28-18-12-20(30)17(25-19(29)7-4-9-31-25)11-16(18)26(37)33-24-13-22(34-35(24)15-5-2-1-3-6-15)27(38)32-21-8-10-39-14-23(21)36/h1-7,9,11-13,21,23,36H,8,10,14H2,(H,32,38)(H,33,37)/t21-,23-/m1/s1 UXSIMKCESQZRSL-FYYLOGMGSA-N 226815 US9328096, 508 High affinity nerve growth factor receptor [441-796] Human 21.1 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226815 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226815&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962964 336293916 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396552 Fc1cccnc1-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)NCc2cccnn2)c(Cl)cc1F InChI=1S/C27H18ClF2N7O2/c28-20-13-22(30)19(25-21(29)9-5-10-31-25)12-18(20)26(38)34-24-14-23(36-37(24)17-7-2-1-3-8-17)27(39)32-15-16-6-4-11-33-35-16/h1-14H,15H2,(H,32,39)(H,34,38) XPYCDHYGZAVLAD-UHFFFAOYSA-N 226816 US9328096, 509 High affinity nerve growth factor receptor [441-796] Human 8.88 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226816 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226816&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962965 336293917 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396553 Fc1cccnc1-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)NCc2cnccn2)c(Cl)cc1F InChI=1S/C27H18ClF2N7O2/c28-20-12-22(30)19(25-21(29)7-4-8-33-25)11-18(20)26(38)35-24-13-23(36-37(24)17-5-2-1-3-6-17)27(39)34-15-16-14-31-9-10-32-16/h1-14H,15H2,(H,34,39)(H,35,38) JIXSQOWKNFQKIJ-UHFFFAOYSA-N 226817 US9328096, 510 High affinity nerve growth factor receptor [441-796] Human 7.01 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226817 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226817&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962966 336293918 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396554 COC[C@@H](CO)NC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C26H22ClF2N5O4/c1-38-14-15(13-35)31-26(37)22-12-23(34(33-22)16-6-3-2-4-7-16)32-25(36)17-10-18(21(29)11-19(17)27)24-20(28)8-5-9-30-24/h2-12,15,35H,13-14H2,1H3,(H,31,37)(H,32,36)/t15-/m1/s1 LCQMXQLWMVDDRR-OAHLLOKOSA-N 226818 US9328096, 511 High affinity nerve growth factor receptor [441-796] Human 25 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226818 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226818&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962967 336293919 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396555 C[C@H](CO)NC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C25H20ClF2N5O3/c1-14(13-34)30-25(36)21-12-22(33(32-21)15-6-3-2-4-7-15)31-24(35)16-10-17(20(28)11-18(16)26)23-19(27)8-5-9-29-23/h2-12,14,34H,13H2,1H3,(H,30,36)(H,31,35)/t14-/m1/s1 NHUIOAVRSHWMLV-CQSZACIVSA-N 226819 US9328096, 512 High affinity nerve growth factor receptor [441-796] Human 17.1 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226819 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226819&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962968 336293920 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396556 Fc1cccnc1-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)N[C@@H]2CCOC2)c(Cl)cc1F InChI=1S/C26H20ClF2N5O3/c27-19-12-21(29)18(24-20(28)7-4-9-30-24)11-17(19)25(35)32-23-13-22(26(36)31-15-8-10-37-14-15)33-34(23)16-5-2-1-3-6-16/h1-7,9,11-13,15H,8,10,14H2,(H,31,36)(H,32,35)/t15-/m1/s1 HVFYQYJAATULPH-OAHLLOKOSA-N 226820 US9328096, 513 High affinity nerve growth factor receptor [441-796] Human 14.2 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226820 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226820&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962969 336293921 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396557 C[C@@H](CO)NC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C25H20ClF2N5O3/c1-14(13-34)30-25(36)21-12-22(33(32-21)15-6-3-2-4-7-15)31-24(35)16-10-17(20(28)11-18(16)26)23-19(27)8-5-9-29-23/h2-12,14,34H,13H2,1H3,(H,30,36)(H,31,35)/t14-/m0/s1 NHUIOAVRSHWMLV-AWEZNQCLSA-N 226821 US9328096, 514 High affinity nerve growth factor receptor [441-796] Human 13.7 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226821 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226821&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962970 336293922 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396558 CNC(=O)CNC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C25H19ClF2N6O3/c1-29-22(35)13-31-25(37)20-12-21(34(33-20)14-6-3-2-4-7-14)32-24(36)15-10-16(19(28)11-17(15)26)23-18(27)8-5-9-30-23/h2-12H,13H2,1H3,(H,29,35)(H,31,37)(H,32,36) ZBYZDPLVQHZZKM-UHFFFAOYSA-N 226822 US9328096, 515 High affinity nerve growth factor receptor [441-796] Human 32 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226822 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226822&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962971 336293923 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396559 Fc1cccnc1-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)N[C@H]2CCOC2)c(Cl)cc1F InChI=1S/C26H20ClF2N5O3/c27-19-12-21(29)18(24-20(28)7-4-9-30-24)11-17(19)25(35)32-23-13-22(26(36)31-15-8-10-37-14-15)33-34(23)16-5-2-1-3-6-16/h1-7,9,11-13,15H,8,10,14H2,(H,31,36)(H,32,35)/t15-/m0/s1 HVFYQYJAATULPH-HNNXBMFYSA-N 226823 US9328096, 516 High affinity nerve growth factor receptor [441-796] Human 21.4 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226823 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226823&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962972 336293924 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396560 CC1(COC1)NC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C26H20ClF2N5O3/c1-26(13-37-14-26)32-25(36)21-12-22(34(33-21)15-6-3-2-4-7-15)31-24(35)16-10-17(20(29)11-18(16)27)23-19(28)8-5-9-30-23/h2-12H,13-14H2,1H3,(H,31,35)(H,32,36) MWBHJXBISTVSOC-UHFFFAOYSA-N 226824 US9328096, 517 High affinity nerve growth factor receptor [441-796] Human 14.8 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226824 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226824&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962973 336293925 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396561 O[C@H]1C[C@@H](C1)NC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C26H20ClF2N5O3/c27-19-12-21(29)18(24-20(28)7-4-8-30-24)11-17(19)25(36)32-23-13-22(26(37)31-14-9-16(35)10-14)33-34(23)15-5-2-1-3-6-15/h1-8,11-14,16,35H,9-10H2,(H,31,37)(H,32,36)/t14-,16- QDTNFFWHVWWFHM-KOMQPUFPSA-N 226825 US9328096, 518 High affinity nerve growth factor receptor [441-796] Human 11.3 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226825 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226825&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962974 336293926 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396562 Fc1cc(Cl)c(cc1-c1ncccc1F)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCc1cnco1 InChI=1S/C26H17ClF2N6O3/c27-19-10-21(29)18(24-20(28)7-4-8-31-24)9-17(19)25(36)33-23-11-22(26(37)32-13-16-12-30-14-38-16)34-35(23)15-5-2-1-3-6-15/h1-12,14H,13H2,(H,32,37)(H,33,36) CZZXASWPTJZFTH-UHFFFAOYSA-N 226826 US9328096, 519 High affinity nerve growth factor receptor [441-796] Human 16.4 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226826 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226826&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962975 336293927 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396563 OC1CN(C1)C(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C25H18ClF2N5O3/c26-18-10-20(28)17(23-19(27)7-4-8-29-23)9-16(18)24(35)30-22-11-21(25(36)32-12-15(34)13-32)31-33(22)14-5-2-1-3-6-14/h1-11,15,34H,12-13H2,(H,30,35) OCMYGSLQJWSZJS-UHFFFAOYSA-N 226827 US9328096, 520 High affinity nerve growth factor receptor [441-796] Human 25.5 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226827 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226827&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962976 336293928 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396564 Fc1cc(Cl)c(cc1-c1ncccc1F)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCc1ccno1 InChI=1S/C26H17ClF2N6O3/c27-19-12-21(29)18(24-20(28)7-4-9-30-24)11-17(19)25(36)33-23-13-22(26(37)31-14-16-8-10-32-38-16)34-35(23)15-5-2-1-3-6-15/h1-13H,14H2,(H,31,37)(H,33,36) QBEVMGMIWNKZGV-UHFFFAOYSA-N 226828 US9328096, 521 High affinity nerve growth factor receptor [441-796] Human 8.14 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226828 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226828&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962977 336293929 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396565 Cc1n[nH]c(CNC(=O)c2cc(NC(=O)c3cc(c(F)cc3Cl)-c3ncccc3F)n(n2)-c2ccccc2)n1 InChI=1S/C26H19ClF2N8O2/c1-14-32-22(35-34-14)13-31-26(39)21-12-23(37(36-21)15-6-3-2-4-7-15)33-25(38)16-10-17(20(29)11-18(16)27)24-19(28)8-5-9-30-24/h2-12H,13H2,1H3,(H,31,39)(H,33,38)(H,32,34,35) JSYZNLXSYUQZRB-UHFFFAOYSA-N 226829 US9328096, 522 High affinity nerve growth factor receptor [441-796] Human 20.3 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226829 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226829&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962978 336293930 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396566 Fc1cc(Cl)c(cc1-c1ncccc1F)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCCn1cncn1 InChI=1S/C26H19ClF2N8O2/c27-19-12-21(29)18(24-20(28)7-4-8-31-24)11-17(19)25(38)34-23-13-22(35-37(23)16-5-2-1-3-6-16)26(39)32-9-10-36-15-30-14-33-36/h1-8,11-15H,9-10H2,(H,32,39)(H,34,38) CKRVSGWFAMBFEV-UHFFFAOYSA-N 226830 US9328096, 523 High affinity nerve growth factor receptor [441-796] Human 16.2 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226830 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226830&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962979 336293931 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396567 NC(=O)C1CCN(C1)C(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C27H21ClF2N6O3/c28-19-12-21(30)18(24-20(29)7-4-9-32-24)11-17(19)26(38)33-23-13-22(34-36(23)16-5-2-1-3-6-16)27(39)35-10-8-15(14-35)25(31)37/h1-7,9,11-13,15H,8,10,14H2,(H2,31,37)(H,33,38) IMRUCOAMCNBEDQ-UHFFFAOYSA-N 226831 US9328096, 524 High affinity nerve growth factor receptor [441-796] Human 75.5 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226831 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226831&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962980 336293932 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396568 O[C@H]1C[C@H](C1)NC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C26H20ClF2N5O3/c27-19-12-21(29)18(24-20(28)7-4-8-30-24)11-17(19)25(36)32-23-13-22(26(37)31-14-9-16(35)10-14)33-34(23)15-5-2-1-3-6-15/h1-8,11-14,16,35H,9-10H2,(H,31,37)(H,32,36)/t14-,16+ QDTNFFWHVWWFHM-FZNQNYSPSA-N 226832 US9328096, 525 High affinity nerve growth factor receptor [441-796] Human 14.2 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226832 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226832&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962974 336293933 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396569 Cn1nncc1CNC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C26H19ClF2N8O2/c1-36-16(14-32-35-36)13-31-26(39)22-12-23(37(34-22)15-6-3-2-4-7-15)33-25(38)17-10-18(21(29)11-19(17)27)24-20(28)8-5-9-30-24/h2-12,14H,13H2,1H3,(H,31,39)(H,33,38) CTMVXLVFVNIEJD-UHFFFAOYSA-N 226833 US9328096, 526 High affinity nerve growth factor receptor [441-796] Human 12.7 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226833 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226833&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962981 336293934 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396570 OCC1(CC1)NC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C26H20ClF2N5O3/c27-18-12-20(29)17(23-19(28)7-4-10-30-23)11-16(18)24(36)31-22-13-21(25(37)32-26(14-35)8-9-26)33-34(22)15-5-2-1-3-6-15/h1-7,10-13,35H,8-9,14H2,(H,31,36)(H,32,37) HVLVVCGKSXSUJV-UHFFFAOYSA-N 226834 US9328096, 527 High affinity nerve growth factor receptor [441-796] Human 11.7 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226834 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226834&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962982 336293935 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396571 OC1(CNC(=O)c2cc(NC(=O)c3cc(c(F)cc3Cl)-c3ncccc3F)n(n2)-c2ccccc2)CC1 InChI=1S/C26H20ClF2N5O3/c27-18-12-20(29)17(23-19(28)7-4-10-30-23)11-16(18)24(35)32-22-13-21(25(36)31-14-26(37)8-9-26)33-34(22)15-5-2-1-3-6-15/h1-7,10-13,37H,8-9,14H2,(H,31,36)(H,32,35) BOBPFKNJPDVTEL-UHFFFAOYSA-N 226835 US9328096, 528 High affinity nerve growth factor receptor [441-796] Human 42.2 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226835 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226835&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962983 336293936 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396572 NC(=O)[C@H]1CCCN(C1)C(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C28H23Cl2FN6O3/c29-20-13-21(30)19(12-18(20)25-22(31)9-4-10-33-25)27(39)34-24-14-23(35-37(24)17-7-2-1-3-8-17)28(40)36-11-5-6-16(15-36)26(32)38/h1-4,7-10,12-14,16H,5-6,11,15H2,(H2,32,38)(H,34,39)/t16-/m0/s1 SJKIZYZUZDJTCX-INIZCTEOSA-N 226836 US9328096, 529 High affinity nerve growth factor receptor [441-796] Human 12.2 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226836 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226836&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962984 336293937 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396573 CNC(=O)CNC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C25H19Cl2FN6O3/c1-29-22(35)13-31-25(37)20-12-21(34(33-20)14-6-3-2-4-7-14)32-24(36)16-10-15(17(26)11-18(16)27)23-19(28)8-5-9-30-23/h2-12H,13H2,1H3,(H,29,35)(H,31,37)(H,32,36) SXCIHYRQYZYBNJ-UHFFFAOYSA-N 226837 US9328096, 530 High affinity nerve growth factor receptor [441-796] Human 9.37 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226837 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226837&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962985 336293938 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396574 OCC1(CC1)NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C26H20Cl2FN5O3/c27-18-12-19(28)17(11-16(18)23-20(29)7-4-10-30-23)24(36)31-22-13-21(25(37)32-26(14-35)8-9-26)33-34(22)15-5-2-1-3-6-15/h1-7,10-13,35H,8-9,14H2,(H,31,36)(H,32,37) RFUXVLYCHJNLGJ-UHFFFAOYSA-N 226838 US9328096, 531 High affinity nerve growth factor receptor [441-796] Human 3.41 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226838 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226838&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962986 336293939 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396575 Fc1cccnc1-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)NCCn2cncn2)c(Cl)cc1Cl InChI=1S/C26H19Cl2FN8O2/c27-19-12-20(28)18(11-17(19)24-21(29)7-4-8-31-24)25(38)34-23-13-22(35-37(23)16-5-2-1-3-6-16)26(39)32-9-10-36-15-30-14-33-36/h1-8,11-15H,9-10H2,(H,32,39)(H,34,38) WCGJQPQFWQFROV-UHFFFAOYSA-N 226839 US9328096, 532 High affinity nerve growth factor receptor [441-796] Human 6.1 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226839 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226839&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962987 336293940 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396576 C[C@H](CO)NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C25H20Cl2FN5O3/c1-14(13-34)30-25(36)21-12-22(33(32-21)15-6-3-2-4-7-15)31-24(35)17-10-16(18(26)11-19(17)27)23-20(28)8-5-9-29-23/h2-12,14,34H,13H2,1H3,(H,30,36)(H,31,35)/t14-/m1/s1 SGUXWMRNTMGMMJ-CQSZACIVSA-N 226840 US9328096, 533 High affinity nerve growth factor receptor [441-796] Human 5.97 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226840 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226840&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962988 336293941 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396577 CN1CC(C1)NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C26H21Cl2FN6O2/c1-34-13-15(14-34)31-26(37)22-12-23(35(33-22)16-6-3-2-4-7-16)32-25(36)18-10-17(19(27)11-20(18)28)24-21(29)8-5-9-30-24/h2-12,15H,13-14H2,1H3,(H,31,37)(H,32,36) RPBQIWCBFFSXPB-UHFFFAOYSA-N 226841 US9328096, 534 High affinity nerve growth factor receptor [441-796] Human 17.3 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226841 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226841&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962989 336293942 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396578 Fc1cccnc1-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)NCc2ccccn2)c(Cl)cc1Cl InChI=1S/C28H19Cl2FN6O2/c29-21-14-22(30)20(13-19(21)26-23(31)10-6-12-33-26)27(38)35-25-15-24(36-37(25)18-8-2-1-3-9-18)28(39)34-16-17-7-4-5-11-32-17/h1-15H,16H2,(H,34,39)(H,35,38) VLHYUOFIGFNQBT-UHFFFAOYSA-N 226842 US9328096, 535 High affinity nerve growth factor receptor [441-796] Human 5.46 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226842 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226842&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962990 336293943 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396579 Fc1cccnc1-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)NCc2cnco2)c(Cl)cc1Cl InChI=1S/C26H17Cl2FN6O3/c27-19-10-20(28)18(9-17(19)24-21(29)7-4-8-31-24)25(36)33-23-11-22(26(37)32-13-16-12-30-14-38-16)34-35(23)15-5-2-1-3-6-15/h1-12,14H,13H2,(H,32,37)(H,33,36) FSZQADZZYYUYPL-UHFFFAOYSA-N 226843 US9328096, 536 High affinity nerve growth factor receptor [441-796] Human 6.13 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226843 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226843&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962991 336293944 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396580 OCCC1(COC1)NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C27H22Cl2FN5O4/c28-19-12-20(29)18(11-17(19)24-21(30)7-4-9-31-24)25(37)32-23-13-22(34-35(23)16-5-2-1-3-6-16)26(38)33-27(8-10-36)14-39-15-27/h1-7,9,11-13,36H,8,10,14-15H2,(H,32,37)(H,33,38) FSIDJRCJYQKJSX-UHFFFAOYSA-N 226844 US9328096, 537 High affinity nerve growth factor receptor [441-796] Human 6.61 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226844 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226844&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962992 336293945 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396581 O[C@H]1CC[C@H](CC1)NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C28H24Cl2FN5O3/c29-21-14-22(30)20(13-19(21)26-23(31)7-4-12-32-26)27(38)34-25-15-24(35-36(25)17-5-2-1-3-6-17)28(39)33-16-8-10-18(37)11-9-16/h1-7,12-16,18,37H,8-11H2,(H,33,39)(H,34,38)/t16-,18+ XOCPTMXSHPKLKW-MAEOIBBWSA-N 226845 US9328096, 538 High affinity nerve growth factor receptor [441-796] Human 4.46 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226845 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226845&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962635 336293946 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396582 CN1CCC(C1)NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C27H23Cl2FN6O2/c1-35-11-9-16(15-35)32-27(38)23-14-24(36(34-23)17-6-3-2-4-7-17)33-26(37)19-12-18(20(28)13-21(19)29)25-22(30)8-5-10-31-25/h2-8,10,12-14,16H,9,11,15H2,1H3,(H,32,38)(H,33,37) KOSKCKOASXSAMP-UHFFFAOYSA-N 226846 US9328096, 539 High affinity nerve growth factor receptor [441-796] Human 15.9 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226846 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226846&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962993 336293947 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396583 Cc1n[nH]cc1NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C26H18Cl2FN7O2/c1-14-22(13-31-34-14)32-26(38)21-12-23(36(35-21)15-6-3-2-4-7-15)33-25(37)17-10-16(18(27)11-19(17)28)24-20(29)8-5-9-30-24/h2-13H,1H3,(H,31,34)(H,32,38)(H,33,37) ZNGXJZWCPBEKCJ-UHFFFAOYSA-N 226847 US9328096, 540 High affinity nerve growth factor receptor [441-796] Human 1.51 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226847 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226847&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962994 336293948 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396584 C[C@@H](O)CNC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C25H20Cl2FN5O3/c1-14(34)13-30-25(36)21-12-22(33(32-21)15-6-3-2-4-7-15)31-24(35)17-10-16(18(26)11-19(17)27)23-20(28)8-5-9-29-23/h2-12,14,34H,13H2,1H3,(H,30,36)(H,31,35)/t14-/m1/s1 ITGHMSHYXORKET-CQSZACIVSA-N 226848 US9328096, 541 High affinity nerve growth factor receptor [441-796] Human 7.09 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226848 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226848&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962995 336293949 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396585 Fc1cccnc1-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)N[C@@H]2CNC(=O)C2)c(Cl)cc1Cl InChI=1S/C26H19Cl2FN6O3/c27-18-11-19(28)17(10-16(18)24-20(29)7-4-8-30-24)25(37)33-22-12-21(26(38)32-14-9-23(36)31-13-14)34-35(22)15-5-2-1-3-6-15/h1-8,10-12,14H,9,13H2,(H,31,36)(H,32,38)(H,33,37)/t14-/m0/s1 BLSVPULEFRSRRV-AWEZNQCLSA-N 226849 US9328096, 542 High affinity nerve growth factor receptor [441-796] Human 35.7 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226849 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226849&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962996 336293950 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396586 O[C@H]1C[C@@H](C1)NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C26H20Cl2FN5O3/c27-19-12-20(28)18(11-17(19)24-21(29)7-4-8-30-24)25(36)32-23-13-22(26(37)31-14-9-16(35)10-14)33-34(23)15-5-2-1-3-6-15/h1-8,11-14,16,35H,9-10H2,(H,31,37)(H,32,36)/t14-,16- HAXIQZOJDSDNAT-KOMQPUFPSA-N 226850 US9328096, 543 High affinity nerve growth factor receptor [441-796] Human 4.69 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226850 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226850&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962997 336293951 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396587 Cn1cc(CNC(=O)c2cc(NC(=O)c3cc(c(Cl)cc3Cl)-c3ncccc3F)n(n2)-c2ccccc2)cn1 InChI=1S/C27H20Cl2FN7O2/c1-36-15-16(14-33-36)13-32-27(39)23-12-24(37(35-23)17-6-3-2-4-7-17)34-26(38)19-10-18(20(28)11-21(19)29)25-22(30)8-5-9-31-25/h2-12,14-15H,13H2,1H3,(H,32,39)(H,34,38) STLKLVIHQBNFMG-UHFFFAOYSA-N 226851 US9328096, 544 High affinity nerve growth factor receptor [441-796] Human 8.12 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226851 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226851&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962998 336293952 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396588 Cc1n[nH]c(CNC(=O)c2cc(NC(=O)c3cc(c(Cl)cc3Cl)-c3ncccc3F)n(n2)-c2ccccc2)n1 InChI=1S/C26H19Cl2FN8O2/c1-14-32-22(35-34-14)13-31-26(39)21-12-23(37(36-21)15-6-3-2-4-7-15)33-25(38)17-10-16(18(27)11-19(17)28)24-20(29)8-5-9-30-24/h2-12H,13H2,1H3,(H,31,39)(H,33,38)(H,32,34,35) MYFZOLSMAURBPG-UHFFFAOYSA-N 226852 US9328096, 545 High affinity nerve growth factor receptor [441-796] Human 9.46 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226852 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226852&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962999 336293953 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396589 OCC1(CNC(=O)c2cc(NC(=O)c3cc(c(Cl)cc3Cl)-c3ncccc3F)n(n2)-c2ccccc2)COC1 InChI=1S/C27H22Cl2FN5O4/c28-19-10-20(29)18(9-17(19)24-21(30)7-4-8-31-24)25(37)33-23-11-22(34-35(23)16-5-2-1-3-6-16)26(38)32-12-27(13-36)14-39-15-27/h1-11,36H,12-15H2,(H,32,38)(H,33,37) XCTBJCRSZHUPEU-UHFFFAOYSA-N 226853 US9328096, 546 High affinity nerve growth factor receptor [441-796] Human 4.14 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226853 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226853&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963000 336293954 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396590 Fc1cccnc1-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)NCc2nnc[nH]2)c(Cl)cc1Cl InChI=1S/C25H17Cl2FN8O2/c26-17-10-18(27)16(9-15(17)23-19(28)7-4-8-29-23)24(37)33-22-11-20(25(38)30-12-21-31-13-32-34-21)35-36(22)14-5-2-1-3-6-14/h1-11,13H,12H2,(H,30,38)(H,33,37)(H,31,32,34) JQRAEZHIXJBKTL-UHFFFAOYSA-N 226854 US9328096, 547 High affinity nerve growth factor receptor [441-796] Human 15.1 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226854 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226854&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963001 336293955 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396591 Fc1cccnc1-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)NCc2ncccn2)c(Cl)cc1Cl InChI=1S/C27H18Cl2FN7O2/c28-19-13-20(29)18(12-17(19)25-21(30)8-4-9-33-25)26(38)35-24-14-22(36-37(24)16-6-2-1-3-7-16)27(39)34-15-23-31-10-5-11-32-23/h1-14H,15H2,(H,34,39)(H,35,38) UCDGAEJUYOUNLR-UHFFFAOYSA-N 226855 US9328096, 548 High affinity nerve growth factor receptor [441-796] Human 9.51 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226855 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226855&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963002 336293956 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396592 Fc1cccnc1-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)NCC2CCOC2)c(Cl)cc1Cl InChI=1S/C27H22Cl2FN5O3/c28-20-12-21(29)19(11-18(20)25-22(30)7-4-9-31-25)26(36)33-24-13-23(27(37)32-14-16-8-10-38-15-16)34-35(24)17-5-2-1-3-6-17/h1-7,9,11-13,16H,8,10,14-15H2,(H,32,37)(H,33,36) AZKYKOVBOLJDIT-UHFFFAOYSA-N 226856 US9328096, 549 High affinity nerve growth factor receptor [441-796] Human 4.66 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226856 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226856&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963003 336293957 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396593 Fc1cccnc1-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)NCc2cocn2)c(Cl)cc1Cl InChI=1S/C26H17Cl2FN6O3/c27-19-10-20(28)18(9-17(19)24-21(29)7-4-8-30-24)25(36)33-23-11-22(26(37)31-12-15-13-38-14-32-15)34-35(23)16-5-2-1-3-6-16/h1-11,13-14H,12H2,(H,31,37)(H,33,36) MKNXYRAHKVTIFO-UHFFFAOYSA-N 226857 US9328096, 550 High affinity nerve growth factor receptor [441-796] Human 5.01 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226857 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226857&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963004 336293958 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396594 Cc1nnc(CNC(=O)c2cc(NC(=O)c3cc(c(Cl)cc3Cl)-c3ncccc3F)n(n2)-c2ccccc2)o1 InChI=1S/C26H18Cl2FN7O3/c1-14-33-34-23(39-14)13-31-26(38)21-12-22(36(35-21)15-6-3-2-4-7-15)32-25(37)17-10-16(18(27)11-19(17)28)24-20(29)8-5-9-30-24/h2-12H,13H2,1H3,(H,31,38)(H,32,37) AOBMGCPWEYMVOS-UHFFFAOYSA-N 226858 US9328096, 551 High affinity nerve growth factor receptor [441-796] Human 6.96 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226858 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226858&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963005 336293959 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396595 CN(C)C(=O)CNC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C26H21Cl2FN6O3/c1-34(2)23(36)14-31-26(38)21-13-22(35(33-21)15-7-4-3-5-8-15)32-25(37)17-11-16(18(27)12-19(17)28)24-20(29)9-6-10-30-24/h3-13H,14H2,1-2H3,(H,31,38)(H,32,37) HTOBUHYIKZOOPH-UHFFFAOYSA-N 226859 US9328096, 552 High affinity nerve growth factor receptor [441-796] Human 10.2 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226859 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226859&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963006 336293960 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396596 C[C@H](O)CNC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C25H20Cl2FN5O3/c1-14(34)13-30-25(36)21-12-22(33(32-21)15-6-3-2-4-7-15)31-24(35)17-10-16(18(26)11-19(17)27)23-20(28)8-5-9-29-23/h2-12,14,34H,13H2,1H3,(H,30,36)(H,31,35)/t14-/m0/s1 ITGHMSHYXORKET-AWEZNQCLSA-N 226860 US9328096, 553 High affinity nerve growth factor receptor [441-796] Human 5.78 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226860 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226860&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963007 336293961 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396597 NC(=O)C1CCN(C1)C(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C27H21Cl2FN6O3/c28-19-12-20(29)18(11-17(19)24-21(30)7-4-9-32-24)26(38)33-23-13-22(34-36(23)16-5-2-1-3-6-16)27(39)35-10-8-15(14-35)25(31)37/h1-7,9,11-13,15H,8,10,14H2,(H2,31,37)(H,33,38) PALVHOMOVWWEAT-UHFFFAOYSA-N 226861 US9328096, 554 High affinity nerve growth factor receptor [441-796] Human 33.4 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226861 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226861&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963008 336293962 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396598 Fc1cccnc1-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)N[C@@H]2CCOC2)c(Cl)cc1Cl InChI=1S/C26H20Cl2FN5O3/c27-19-12-20(28)18(11-17(19)24-21(29)7-4-9-30-24)25(35)32-23-13-22(26(36)31-15-8-10-37-14-15)33-34(23)16-5-2-1-3-6-16/h1-7,9,11-13,15H,8,10,14H2,(H,31,36)(H,32,35)/t15-/m1/s1 AADGFLAQHXJJRJ-OAHLLOKOSA-N 226862 US9328096, 555 High affinity nerve growth factor receptor [441-796] Human 4.41 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226862 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226862&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963009 336293963 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396599 COC[C@@H](CO)NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C26H22Cl2FN5O4/c1-38-14-15(13-35)31-26(37)22-12-23(34(33-22)16-6-3-2-4-7-16)32-25(36)18-10-17(19(27)11-20(18)28)24-21(29)8-5-9-30-24/h2-12,15,35H,13-14H2,1H3,(H,31,37)(H,32,36)/t15-/m1/s1 FQYMYLOEAQJKSW-OAHLLOKOSA-N 226863 US9328096, 556 High affinity nerve growth factor receptor [441-796] Human 8.96 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226863 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226863&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963010 336293964 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396600 Nc1cc(CNC(=O)c2cc(NC(=O)c3cc(c(Cl)cc3Cl)-c3ncccc3F)n(n2)-c2ccccc2)ccn1 InChI=1S/C28H20Cl2FN7O2/c29-20-13-21(30)19(12-18(20)26-22(31)7-4-9-34-26)27(39)36-25-14-23(37-38(25)17-5-2-1-3-6-17)28(40)35-15-16-8-10-33-24(32)11-16/h1-14H,15H2,(H2,32,33)(H,35,40)(H,36,39) MHLMSUYMXKKJDN-UHFFFAOYSA-N 226864 US9328096, 557 High affinity nerve growth factor receptor [441-796] Human 1.02 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226864 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226864&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963011 336293965 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396601 Fc1cccnc1-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)NC2CC2)c(Cl)cc1Cl InChI=1S/C25H18Cl2FN5O2/c26-18-12-19(27)17(11-16(18)23-20(28)7-4-10-29-23)24(34)31-22-13-21(25(35)30-14-8-9-14)32-33(22)15-5-2-1-3-6-15/h1-7,10-14H,8-9H2,(H,30,35)(H,31,34) LRVZKTLMYJSASR-UHFFFAOYSA-N 226865 US9328096, 558 High affinity nerve growth factor receptor [441-796] Human 4.02 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226865 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226865&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963012 336293966 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396602 Fc1cccnc1-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)NCc2ccncn2)c(Cl)cc1Cl InChI=1S/C27H18Cl2FN7O2/c28-20-12-21(29)19(11-18(20)25-22(30)7-4-9-32-25)26(38)35-24-13-23(36-37(24)17-5-2-1-3-6-17)27(39)33-14-16-8-10-31-15-34-16/h1-13,15H,14H2,(H,33,39)(H,35,38) GLPKFZXEOHZULY-UHFFFAOYSA-N 226866 US9328096, 559 High affinity nerve growth factor receptor [441-796] Human 4.68 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226866 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226866&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963013 336293967 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396603 Fc1cccnc1-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)NCCn2ccnn2)c(Cl)cc1Cl InChI=1S/C26H19Cl2FN8O2/c27-19-14-20(28)18(13-17(19)24-21(29)7-4-8-30-24)25(38)33-23-15-22(34-37(23)16-5-2-1-3-6-16)26(39)31-9-11-36-12-10-32-35-36/h1-8,10,12-15H,9,11H2,(H,31,39)(H,33,38) LVRQBVYRKPMKNN-UHFFFAOYSA-N 226867 US9328096, 560 High affinity nerve growth factor receptor [441-796] Human 7.59 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226867 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226867&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963014 336293968 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396604 CC1(O)CCC(CC1)NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C29H26Cl2FN5O3/c1-29(40)11-9-17(10-12-29)34-28(39)24-16-25(37(36-24)18-6-3-2-4-7-18)35-27(38)20-14-19(21(30)15-22(20)31)26-23(32)8-5-13-33-26/h2-8,13-17,40H,9-12H2,1H3,(H,34,39)(H,35,38) IZOZEJPKBMFELE-UHFFFAOYSA-N 226868 US9328096, 561 High affinity nerve growth factor receptor [441-796] Human 8.36 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226868 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226868&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963015 336293969 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396605 Fc1cccnc1-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)NC2COC2)c(Cl)cc1Cl InChI=1S/C25H18Cl2FN5O3/c26-18-10-19(27)17(9-16(18)23-20(28)7-4-8-29-23)24(34)31-22-11-21(25(35)30-14-12-36-13-14)32-33(22)15-5-2-1-3-6-15/h1-11,14H,12-13H2,(H,30,35)(H,31,34) ULTWJLBSBFNBEP-UHFFFAOYSA-N 226869 US9328096, 562 High affinity nerve growth factor receptor [441-796] Human 7.22 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226869 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226869&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963016 336293970 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396606 CNC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C23H16Cl2FN5O2/c1-27-23(33)19-12-20(31(30-19)13-6-3-2-4-7-13)29-22(32)15-10-14(16(24)11-17(15)25)21-18(26)8-5-9-28-21/h2-12H,1H3,(H,27,33)(H,29,32) XRIZWQSELZEBOJ-UHFFFAOYSA-N 226870 US9328096, 563 High affinity nerve growth factor receptor [441-796] Human 5.12 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226870 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226870&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963017 336293971 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396607 CCNC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C24H18Cl2FN5O2/c1-2-28-24(34)20-13-21(32(31-20)14-7-4-3-5-8-14)30-23(33)16-11-15(17(25)12-18(16)26)22-19(27)9-6-10-29-22/h3-13H,2H2,1H3,(H,28,34)(H,30,33) TXXZKUQDQFSTAS-UHFFFAOYSA-N 226871 US9328096, 564 High affinity nerve growth factor receptor [441-796] Human 4.97 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226871 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226871&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963018 336293972 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396608 Fc1cccnc1-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)NC2CCOCC2)c(Cl)cc1Cl InChI=1S/C27H22Cl2FN5O3/c28-20-14-21(29)19(13-18(20)25-22(30)7-4-10-31-25)26(36)33-24-15-23(27(37)32-16-8-11-38-12-9-16)34-35(24)17-5-2-1-3-6-17/h1-7,10,13-16H,8-9,11-12H2,(H,32,37)(H,33,36) LTGCEVDMGOSBGP-UHFFFAOYSA-N 226872 US9328096, 565 High affinity nerve growth factor receptor [441-796] Human 8.9 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226872 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226872&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963019 336293973 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396609 CC(CO)NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C25H20Cl2FN5O3/c1-14(13-34)30-25(36)21-12-22(33(32-21)15-6-3-2-4-7-15)31-24(35)17-10-16(18(26)11-19(17)27)23-20(28)8-5-9-29-23/h2-12,14,34H,13H2,1H3,(H,30,36)(H,31,35) SGUXWMRNTMGMMJ-UHFFFAOYSA-N 226873 US9328096, 566 High affinity nerve growth factor receptor [441-796] Human 6.32 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226873 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226873&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963020 336293974 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396610 Cn1cc(CNC(=O)c2cc(NC(=O)c3cc(c(Cl)cc3Cl)-c3ncccc3F)n(n2)-c2ccccc2)nn1 InChI=1S/C26H19Cl2FN8O2/c1-36-14-15(33-35-36)13-31-26(39)22-12-23(37(34-22)16-6-3-2-4-7-16)32-25(38)18-10-17(19(27)11-20(18)28)24-21(29)8-5-9-30-24/h2-12,14H,13H2,1H3,(H,31,39)(H,32,38) CAPZQXPZQVFULR-UHFFFAOYSA-N 226874 US9328096, 567 High affinity nerve growth factor receptor [441-796] Human 3.22 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226874 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226874&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963021 336293975 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396611 Fc1cccnc1-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)NCC2CCC(=O)N2)c(Cl)cc1Cl InChI=1S/C27H21Cl2FN6O3/c28-19-12-20(29)18(11-17(19)25-21(30)7-4-10-31-25)26(38)34-23-13-22(35-36(23)16-5-2-1-3-6-16)27(39)32-14-15-8-9-24(37)33-15/h1-7,10-13,15H,8-9,14H2,(H,32,39)(H,33,37)(H,34,38) LIVDWEITTFPWPI-UHFFFAOYSA-N 226875 US9328096, 568 High affinity nerve growth factor receptor [441-796] Human 17.6 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226875 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226875&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963022 336293976 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396612 Fc1cccnc1-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)N[C@H]2CCOC2)c(Cl)cc1Cl InChI=1S/C26H20Cl2FN5O3/c27-19-12-20(28)18(11-17(19)24-21(29)7-4-9-30-24)25(35)32-23-13-22(26(36)31-15-8-10-37-14-15)33-34(23)16-5-2-1-3-6-16/h1-7,9,11-13,15H,8,10,14H2,(H,31,36)(H,32,35)/t15-/m0/s1 AADGFLAQHXJJRJ-HNNXBMFYSA-N 226876 US9328096, 569 High affinity nerve growth factor receptor [441-796] Human 8.51 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226876 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226876&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963023 336293977 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396613 C[C@@H](CO)NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C25H20Cl2FN5O3/c1-14(13-34)30-25(36)21-12-22(33(32-21)15-6-3-2-4-7-15)31-24(35)17-10-16(18(26)11-19(17)27)23-20(28)8-5-9-29-23/h2-12,14,34H,13H2,1H3,(H,30,36)(H,31,35)/t14-/m0/s1 SGUXWMRNTMGMMJ-AWEZNQCLSA-N 226877 US9328096, 570 High affinity nerve growth factor receptor [441-796] Human 4.73 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226877 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226877&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963024 336293978 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396614 CC1(COC1)NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C26H20Cl2FN5O3/c1-26(13-37-14-26)32-25(36)21-12-22(34(33-21)15-6-3-2-4-7-15)31-24(35)17-10-16(18(27)11-19(17)28)23-20(29)8-5-9-30-23/h2-12H,13-14H2,1H3,(H,31,35)(H,32,36) JHUZLWZTVZGNEW-UHFFFAOYSA-N 226878 US9328096, 571 High affinity nerve growth factor receptor [441-796] Human 5.95 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226878 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226878&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963025 336293979 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396615 OCCCNC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C25H20Cl2FN5O3/c26-18-13-19(27)17(12-16(18)23-20(28)8-4-9-29-23)24(35)31-22-14-21(25(36)30-10-5-11-34)32-33(22)15-6-2-1-3-7-15/h1-4,6-9,12-14,34H,5,10-11H2,(H,30,36)(H,31,35) UXCWNNZJHRQFKK-UHFFFAOYSA-N 226879 US9328096, 572 High affinity nerve growth factor receptor [441-796] Human 4.36 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226879 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226879&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963026 336293980 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396616 COCCNC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C25H20Cl2FN5O3/c1-36-11-10-30-25(35)21-14-22(33(32-21)15-6-3-2-4-7-15)31-24(34)17-12-16(18(26)13-19(17)27)23-20(28)8-5-9-29-23/h2-9,12-14H,10-11H2,1H3,(H,30,35)(H,31,34) YYKVECUVQRPCGU-UHFFFAOYSA-N 226880 US9328096, 573 High affinity nerve growth factor receptor [441-796] Human 9 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226880&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963027 336293981 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396617 Fc1cccnc1-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)NCc2ccno2)c(Cl)cc1Cl InChI=1S/C26H17Cl2FN6O3/c27-19-12-20(28)18(11-17(19)24-21(29)7-4-9-30-24)25(36)33-23-13-22(26(37)31-14-16-8-10-32-38-16)34-35(23)15-5-2-1-3-6-15/h1-13H,14H2,(H,31,37)(H,33,36) LOTSADQJYRXQTO-UHFFFAOYSA-N 226881 US9328096, 574 High affinity nerve growth factor receptor [441-796] Human 2.46 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226881 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226881&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963028 336293982 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396618 Fc1cccnc1-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)NCc2cccnn2)c(Cl)cc1Cl InChI=1S/C27H18Cl2FN7O2/c28-20-13-21(29)19(12-18(20)25-22(30)9-5-10-31-25)26(38)34-24-14-23(36-37(24)17-7-2-1-3-8-17)27(39)32-15-16-6-4-11-33-35-16/h1-14H,15H2,(H,32,39)(H,34,38) WWRZVLBGVFPEKO-UHFFFAOYSA-N 226882 US9328096, 575 High affinity nerve growth factor receptor [441-796] Human 3.21 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226882 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226882&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963029 336293983 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396619 Fc1cccnc1-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)NCc2ncco2)c(Cl)cc1Cl InChI=1S/C26H17Cl2FN6O3/c27-18-12-19(28)17(11-16(18)24-20(29)7-4-8-31-24)25(36)33-22-13-21(26(37)32-14-23-30-9-10-38-23)34-35(22)15-5-2-1-3-6-15/h1-13H,14H2,(H,32,37)(H,33,36) FVHBUXUICAFLNI-UHFFFAOYSA-N 226883 US9328096, 576 High affinity nerve growth factor receptor [441-796] Human 20.2 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226883 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226883&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963030 336293984 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396620 Fc1cccnc1-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)NCC2COC2)c(Cl)cc1Cl InChI=1S/C26H20Cl2FN5O3/c27-19-10-20(28)18(9-17(19)24-21(29)7-4-8-30-24)25(35)32-23-11-22(26(36)31-12-15-13-37-14-15)33-34(23)16-5-2-1-3-6-16/h1-11,15H,12-14H2,(H,31,36)(H,32,35) GQBKDIQVJQBIKV-UHFFFAOYSA-N 226884 US9328096, 577 High affinity nerve growth factor receptor [441-796] Human 10.3 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226884 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226884&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963031 336293985 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396621 Fc1cccnc1-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)NCc2cnccn2)c(Cl)cc1Cl InChI=1S/C27H18Cl2FN7O2/c28-20-12-21(29)19(11-18(20)25-22(30)7-4-8-33-25)26(38)35-24-13-23(36-37(24)17-5-2-1-3-6-17)27(39)34-15-16-14-31-9-10-32-16/h1-14H,15H2,(H,34,39)(H,35,38) FHJURHLZTYAZRC-UHFFFAOYSA-N 226885 US9328096, 578 High affinity nerve growth factor receptor [441-796] Human 5.97 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226885 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226885&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963032 336293986 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396622 Fc1cccnc1-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)NCc2ccon2)c(Cl)cc1Cl InChI=1S/C26H17Cl2FN6O3/c27-19-12-20(28)18(11-17(19)24-21(29)7-4-9-30-24)25(36)32-23-13-22(26(37)31-14-15-8-10-38-34-15)33-35(23)16-5-2-1-3-6-16/h1-13H,14H2,(H,31,37)(H,32,36) LZBDDZMLORLMGY-UHFFFAOYSA-N 226886 US9328096, 579 High affinity nerve growth factor receptor [441-796] Human 5.15 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226886 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226886&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963033 336293987 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396623 OC1(CNC(=O)c2cc(NC(=O)c3cc(c(Cl)cc3Cl)-c3ncccc3F)n(n2)-c2ccccc2)CC1 InChI=1S/C26H20Cl2FN5O3/c27-18-12-19(28)17(11-16(18)23-20(29)7-4-10-30-23)24(35)32-22-13-21(25(36)31-14-26(37)8-9-26)33-34(22)15-5-2-1-3-6-15/h1-7,10-13,37H,8-9,14H2,(H,31,36)(H,32,35) FDQNSDGASQJFPU-UHFFFAOYSA-N 226887 US9328096, 580 High affinity nerve growth factor receptor [441-796] Human 6.37 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226887 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226887&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963034 336293988 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396624 O[C@H]1C[C@H](C1)NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C26H20Cl2FN5O3/c27-19-12-20(28)18(11-17(19)24-21(29)7-4-8-30-24)25(36)32-23-13-22(26(37)31-14-9-16(35)10-14)33-34(23)15-5-2-1-3-6-15/h1-8,11-14,16,35H,9-10H2,(H,31,37)(H,32,36)/t14-,16+ HAXIQZOJDSDNAT-FZNQNYSPSA-N 226888 US9328096, 581 High affinity nerve growth factor receptor [441-796] Human 5.83 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226888 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226888&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962997 336293989 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396625 Clc1cc(Cl)c(cc1C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCCn1cncn1)-c1ccccn1 InChI=1S/C26H20Cl2N8O2/c27-20-13-21(28)19(12-18(20)22-8-4-5-9-30-22)25(37)33-24-14-23(34-36(24)17-6-2-1-3-7-17)26(38)31-10-11-35-16-29-15-32-35/h1-9,12-16H,10-11H2,(H,31,38)(H,33,37) KHSXKESWEHCDIU-UHFFFAOYSA-N 226889 US9328096, 582 High affinity nerve growth factor receptor [441-796] Human 9.94 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226889 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226889&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963035 336293990 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396626 Clc1cc(Cl)c(cc1C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCc1cocn1)-c1ccccn1 InChI=1S/C26H18Cl2N6O3/c27-20-11-21(28)19(10-18(20)22-8-4-5-9-29-22)25(35)32-24-12-23(26(36)30-13-16-14-37-15-31-16)33-34(24)17-6-2-1-3-7-17/h1-12,14-15H,13H2,(H,30,36)(H,32,35) QWPVUTOPNJCCGY-UHFFFAOYSA-N 226890 US9328096, 583 High affinity nerve growth factor receptor [441-796] Human 7.64 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226890 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226890&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963036 336293991 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396627 Fc1cccnc1-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)NCc2ccon2)c(Cl)cc1Cl InChI=1S/C26H17Cl2FN6O3/c27-19-12-20(28)18(11-17(19)24-21(29)7-4-9-30-24)25(36)32-23-13-22(26(37)31-14-15-8-10-38-34-15)33-35(23)16-5-2-1-3-6-16/h1-13H,14H2,(H,31,37)(H,32,36) LZBDDZMLORLMGY-UHFFFAOYSA-N 226886 US9328096, 579 High affinity nerve growth factor receptor [441-796] Human 5.15 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226886 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226886&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963033 336293987 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396628 OC1(CNC(=O)c2cc(NC(=O)c3cc(c(Cl)cc3Cl)-c3ncccc3F)n(n2)-c2ccccc2)CC1 InChI=1S/C26H20Cl2FN5O3/c27-18-12-19(28)17(11-16(18)23-20(29)7-4-10-30-23)24(35)32-22-13-21(25(36)31-14-26(37)8-9-26)33-34(22)15-5-2-1-3-6-15/h1-7,10-13,37H,8-9,14H2,(H,31,36)(H,32,35) FDQNSDGASQJFPU-UHFFFAOYSA-N 226887 US9328096, 580 High affinity nerve growth factor receptor [441-796] Human 6.37 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226887 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226887&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963034 336293988 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396629 O[C@H]1C[C@H](C1)NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C26H20Cl2FN5O3/c27-19-12-20(28)18(11-17(19)24-21(29)7-4-8-30-24)25(36)32-23-13-22(26(37)31-14-9-16(35)10-14)33-34(23)15-5-2-1-3-6-15/h1-8,11-14,16,35H,9-10H2,(H,31,37)(H,32,36)/t14-,16+ HAXIQZOJDSDNAT-FZNQNYSPSA-N 226888 US9328096, 581 High affinity nerve growth factor receptor [441-796] Human 5.83 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226888 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226888&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962997 336293989 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396630 Clc1cc(Cl)c(cc1C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCCn1cncn1)-c1ccccn1 InChI=1S/C26H20Cl2N8O2/c27-20-13-21(28)19(12-18(20)22-8-4-5-9-30-22)25(37)33-24-14-23(34-36(24)17-6-2-1-3-7-17)26(38)31-10-11-35-16-29-15-32-35/h1-9,12-16H,10-11H2,(H,31,38)(H,33,37) KHSXKESWEHCDIU-UHFFFAOYSA-N 226889 US9328096, 582 High affinity nerve growth factor receptor [441-796] Human 9.94 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226889 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226889&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963035 336293990 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396631 Clc1cc(Cl)c(cc1C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCc1cocn1)-c1ccccn1 InChI=1S/C26H18Cl2N6O3/c27-20-11-21(28)19(10-18(20)22-8-4-5-9-29-22)25(35)32-24-12-23(26(36)30-13-16-14-37-15-31-16)33-34(24)17-6-2-1-3-7-17/h1-12,14-15H,13H2,(H,30,36)(H,32,35) QWPVUTOPNJCCGY-UHFFFAOYSA-N 226890 US9328096, 583 High affinity nerve growth factor receptor [441-796] Human 7.64 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226890 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226890&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963036 336293991 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396632 CN1CCC(C1)NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C27H24Cl2N6O2/c1-34-12-10-17(16-34)31-27(37)24-15-25(35(33-24)18-7-3-2-4-8-18)32-26(36)20-13-19(21(28)14-22(20)29)23-9-5-6-11-30-23/h2-9,11,13-15,17H,10,12,16H2,1H3,(H,31,37)(H,32,36) OAYQAGHZYSFONQ-UHFFFAOYSA-N 226896 US9328096, 584 High affinity nerve growth factor receptor [441-796] Human 29.1 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226896 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226896&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963037 336293992 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396633 CN(C)C(=O)CNC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C26H22Cl2N6O3/c1-33(2)24(35)15-30-26(37)22-14-23(34(32-22)16-8-4-3-5-9-16)31-25(36)18-12-17(19(27)13-20(18)28)21-10-6-7-11-29-21/h3-14H,15H2,1-2H3,(H,30,37)(H,31,36) WIKJCMBRDLUQGR-UHFFFAOYSA-N 226897 US9328096, 585 High affinity nerve growth factor receptor [441-796] Human 21.9 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226897 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226897&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963038 336293993 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396634 Clc1cc(Cl)c(cc1C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCc1ncccn1)-c1ccccn1 InChI=1S/C27H19Cl2N7O2/c28-20-14-21(29)19(13-18(20)22-9-4-5-10-30-22)26(37)34-25-15-23(35-36(25)17-7-2-1-3-8-17)27(38)33-16-24-31-11-6-12-32-24/h1-15H,16H2,(H,33,38)(H,34,37) CERUCUMPIOKGHV-UHFFFAOYSA-N 226898 US9328096, 586 High affinity nerve growth factor receptor [441-796] Human 13.6 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226898 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226898&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963039 336293994 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396635 OCCOCCNC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C26H23Cl2N5O4/c27-20-15-21(28)19(14-18(20)22-8-4-5-9-29-22)25(35)31-24-16-23(26(36)30-10-12-37-13-11-34)32-33(24)17-6-2-1-3-7-17/h1-9,14-16,34H,10-13H2,(H,30,36)(H,31,35) KLNHNNKVVVTKGE-UHFFFAOYSA-N 226899 US9328096, 587 High affinity nerve growth factor receptor [441-796] Human 14.5 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226899 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226899&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963040 336293995 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396636 Clc1cc(Cl)c(cc1C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCC1CCOC1)-c1ccccn1 InChI=1S/C27H23Cl2N5O3/c28-21-13-22(29)20(12-19(21)23-8-4-5-10-30-23)26(35)32-25-14-24(27(36)31-15-17-9-11-37-16-17)33-34(25)18-6-2-1-3-7-18/h1-8,10,12-14,17H,9,11,15-16H2,(H,31,36)(H,32,35) FQCOQENDWCQMKS-UHFFFAOYSA-N 226900 US9328096, 588 High affinity nerve growth factor receptor [441-796] Human 8.6 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226900 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226900&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963041 336293996 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396637 Clc1cc(Cl)c(cc1C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCc1ccccn1)-c1ccccn1 InChI=1S/C28H20Cl2N6O2/c29-22-15-23(30)21(14-20(22)24-11-5-7-13-32-24)27(37)34-26-16-25(35-36(26)19-9-2-1-3-10-19)28(38)33-17-18-8-4-6-12-31-18/h1-16H,17H2,(H,33,38)(H,34,37) QWYYXAWTFIUCEF-UHFFFAOYSA-N 226901 US9328096, 589 High affinity nerve growth factor receptor [441-796] Human 6.67 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226901 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226901&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963042 336293997 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396638 O[C@H]1C[C@@H](C1)NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C26H21Cl2N5O3/c27-20-13-21(28)19(12-18(20)22-8-4-5-9-29-22)25(35)31-24-14-23(26(36)30-15-10-17(34)11-15)32-33(24)16-6-2-1-3-7-16/h1-9,12-15,17,34H,10-11H2,(H,30,36)(H,31,35)/t15-,17- VNMUFZWLOJBHEH-JCNLHEQBSA-N 226902 US9328096, 590 High affinity nerve growth factor receptor [441-796] Human 7.46 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226902 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226902&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963043 336293998 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396639 Clc1cc(Cl)c(cc1C(=O)Nc1cc(nn1-c1ccccc1)C(=O)N[C@@H]1CNC(=O)C1)-c1ccccn1 InChI=1S/C26H20Cl2N6O3/c27-19-12-20(28)18(11-17(19)21-8-4-5-9-29-21)25(36)32-23-13-22(26(37)31-15-10-24(35)30-14-15)33-34(23)16-6-2-1-3-7-16/h1-9,11-13,15H,10,14H2,(H,30,35)(H,31,37)(H,32,36)/t15-/m0/s1 FDHWNENGUNKCAE-HNNXBMFYSA-N 226903 US9328096, 591 High affinity nerve growth factor receptor [441-796] Human 118 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226903 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226903&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963044 336293999 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396640 OC[C@H](O)CNC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C25H21Cl2N5O4/c26-19-11-20(27)18(10-17(19)21-8-4-5-9-28-21)24(35)30-23-12-22(25(36)29-13-16(34)14-33)31-32(23)15-6-2-1-3-7-15/h1-12,16,33-34H,13-14H2,(H,29,36)(H,30,35)/t16-/m1/s1 SBSHXTYYDODCNO-MRXNPFEDSA-N 226904 US9328096, 592 High affinity nerve growth factor receptor [441-796] Human 26.5 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226904 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226904&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963045 336294000 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396641 Clc1cc(Cl)c(cc1C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCc1ncco1)-c1ccccn1 InChI=1S/C26H18Cl2N6O3/c27-19-13-20(28)18(12-17(19)21-8-4-5-9-29-21)25(35)32-23-14-22(26(36)31-15-24-30-10-11-37-24)33-34(23)16-6-2-1-3-7-16/h1-14H,15H2,(H,31,36)(H,32,35) KJLPDXXGOCIJOH-UHFFFAOYSA-N 226905 US9328096, 593 High affinity nerve growth factor receptor [441-796] Human 18.7 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226905 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226905&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963046 336294001 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396642 Clc1cc(Cl)c(cc1C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCCn1ccnn1)-c1ccccn1 InChI=1S/C26H20Cl2N8O2/c27-20-15-21(28)19(14-18(20)22-8-4-5-9-29-22)25(37)32-24-16-23(33-36(24)17-6-2-1-3-7-17)26(38)30-10-12-35-13-11-31-34-35/h1-9,11,13-16H,10,12H2,(H,30,38)(H,32,37) YQJZTUPPVBIWFP-UHFFFAOYSA-N 226906 US9328096, 594 High affinity nerve growth factor receptor [441-796] Human 11.9 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226906 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226906&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963047 336294002 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396643 Clc1cc(Cl)c(cc1C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NC1CC1)-c1ccccn1 InChI=1S/C25H19Cl2N5O2/c26-19-13-20(27)18(12-17(19)21-8-4-5-11-28-21)24(33)30-23-14-22(25(34)29-15-9-10-15)31-32(23)16-6-2-1-3-7-16/h1-8,11-15H,9-10H2,(H,29,34)(H,30,33) SYQRBLLRZOOUJH-UHFFFAOYSA-N 226907 US9328096, 595 High affinity nerve growth factor receptor [441-796] Human 6.33 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226907 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226907&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963048 336294003 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396644 O[C@@H]1COC[C@H]1NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C26H21Cl2N5O4/c27-18-11-19(28)17(10-16(18)20-8-4-5-9-29-20)25(35)31-24-12-21(26(36)30-22-13-37-14-23(22)34)32-33(24)15-6-2-1-3-7-15/h1-12,22-23,34H,13-14H2,(H,30,36)(H,31,35)/t22-,23-/m1/s1 UFTQWQVOZWPVKL-DHIUTWEWSA-N 226908 US9328096, 596 High affinity nerve growth factor receptor [441-796] Human 16.7 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226908 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226908&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963049 336294004 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396645 Clc1cc(Cl)c(cc1C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCc1ccncn1)-c1ccccn1 InChI=1S/C27H19Cl2N7O2/c28-21-13-22(29)20(12-19(21)23-8-4-5-10-31-23)26(37)34-25-14-24(35-36(25)18-6-2-1-3-7-18)27(38)32-15-17-9-11-30-16-33-17/h1-14,16H,15H2,(H,32,38)(H,34,37) HQHWDIYYUZRMGH-UHFFFAOYSA-N 226909 US9328096, 597 High affinity nerve growth factor receptor [441-796] Human 9.1 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226909 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226909&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963050 336294005 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396646 NC(=O)C1CCN(C1)C(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C27H22Cl2N6O3/c28-20-13-21(29)19(12-18(20)22-8-4-5-10-31-22)26(37)32-24-14-23(33-35(24)17-6-2-1-3-7-17)27(38)34-11-9-16(15-34)25(30)36/h1-8,10,12-14,16H,9,11,15H2,(H2,30,36)(H,32,37) FDIXOKWOAQTABX-UHFFFAOYSA-N 226910 US9328096, 598 High affinity nerve growth factor receptor [441-796] Human 75.1 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226910 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226910&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963051 336294006 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396647 OC1CN(C1)C(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C25H19Cl2N5O3/c26-19-11-20(27)18(10-17(19)21-8-4-5-9-28-21)24(34)29-23-12-22(25(35)31-13-16(33)14-31)30-32(23)15-6-2-1-3-7-15/h1-12,16,33H,13-14H2,(H,29,34) DGTCCBWZCOHBLV-UHFFFAOYSA-N 226911 US9328096, 599 High affinity nerve growth factor receptor [441-796] Human 20.4 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226911 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226911&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963052 336294007 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396648 CNC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C23H17Cl2N5O2/c1-26-23(32)20-13-21(30(29-20)14-7-3-2-4-8-14)28-22(31)16-11-15(17(24)12-18(16)25)19-9-5-6-10-27-19/h2-13H,1H3,(H,26,32)(H,28,31) MTYFTBCSRDWQTA-UHFFFAOYSA-N 226912 US9328096, 600 High affinity nerve growth factor receptor [441-796] Human 7.06 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226912 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226912&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963053 336294008 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396649 COCCNC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C25H21Cl2N5O3/c1-35-12-11-29-25(34)22-15-23(32(31-22)16-7-3-2-4-8-16)30-24(33)18-13-17(19(26)14-20(18)27)21-9-5-6-10-28-21/h2-10,13-15H,11-12H2,1H3,(H,29,34)(H,30,33) GDHNHLTZHCAMCR-UHFFFAOYSA-N 226913 US9328096, 601 High affinity nerve growth factor receptor [441-796] Human 9.67 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226913 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226913&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963054 336294009 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396650 Cc1nnc(CNC(=O)c2cc(NC(=O)c3cc(c(Cl)cc3Cl)-c3ccccn3)n(n2)-c2ccccc2)o1 InChI=1S/C26H19Cl2N7O3/c1-15-32-33-24(38-15)14-30-26(37)22-13-23(35(34-22)16-7-3-2-4-8-16)31-25(36)18-11-17(19(27)12-20(18)28)21-9-5-6-10-29-21/h2-13H,14H2,1H3,(H,30,37)(H,31,36) HBLQIKLZGCDLAH-UHFFFAOYSA-N 226914 US9328096, 602 High affinity nerve growth factor receptor [441-796] Human 11.7 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226914 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226914&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963055 336294010 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396651 Clc1cc(Cl)c(cc1C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NC1CCOCC1)-c1ccccn1 InChI=1S/C27H23Cl2N5O3/c28-21-15-22(29)20(14-19(21)23-8-4-5-11-30-23)26(35)32-25-16-24(27(36)31-17-9-12-37-13-10-17)33-34(25)18-6-2-1-3-7-18/h1-8,11,14-17H,9-10,12-13H2,(H,31,36)(H,32,35) KTQHIZPVIWNHSH-UHFFFAOYSA-N 226915 US9328096, 603 High affinity nerve growth factor receptor [441-796] Human 28 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226915 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226915&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963056 336294011 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396652 CCNC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C24H19Cl2N5O2/c1-2-27-24(33)21-14-22(31(30-21)15-8-4-3-5-9-15)29-23(32)17-12-16(18(25)13-19(17)26)20-10-6-7-11-28-20/h3-14H,2H2,1H3,(H,27,33)(H,29,32) SIRKQAJYRXKITH-UHFFFAOYSA-N 226916 US9328096, 604 High affinity nerve growth factor receptor [441-796] Human 9.17 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226916 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226916&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963057 336294012 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396653 NC(=O)[C@H]1CCCN(C1)C(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C28H24Cl2N6O3/c29-21-14-22(30)20(13-19(21)23-10-4-5-11-32-23)27(38)33-25-15-24(34-36(25)18-8-2-1-3-9-18)28(39)35-12-6-7-17(16-35)26(31)37/h1-5,8-11,13-15,17H,6-7,12,16H2,(H2,31,37)(H,33,38)/t17-/m0/s1 FTMJZWKFHHNTRI-KRWDZBQOSA-N 226917 US9328096, 605 High affinity nerve growth factor receptor [441-796] Human 31.4 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226917 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226917&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963058 336294013 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396654 OCC1(CC1)NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C26H21Cl2N5O3/c27-19-13-20(28)18(12-17(19)21-8-4-5-11-29-21)24(35)30-23-14-22(25(36)31-26(15-34)9-10-26)32-33(23)16-6-2-1-3-7-16/h1-8,11-14,34H,9-10,15H2,(H,30,35)(H,31,36) DYKQBEAZVGVTCW-UHFFFAOYSA-N 226918 US9328096, 606 High affinity nerve growth factor receptor [441-796] Human 6.49 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226918 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226918&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963059 336294014 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396655 Cn1cc(CNC(=O)c2cc(NC(=O)c3cc(c(Cl)cc3Cl)-c3ccccn3)n(n2)-c2ccccc2)nn1 InChI=1S/C26H20Cl2N8O2/c1-35-15-16(32-34-35)14-30-26(38)23-13-24(36(33-23)17-7-3-2-4-8-17)31-25(37)19-11-18(20(27)12-21(19)28)22-9-5-6-10-29-22/h2-13,15H,14H2,1H3,(H,30,38)(H,31,37) LSFHVEHSZCNNDG-UHFFFAOYSA-N 226919 US9328096, 607 High affinity nerve growth factor receptor [441-796] Human 4.92 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226919 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226919&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963060 336294015 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396656 Clc1cc(Cl)c(cc1C(=O)Nc1cc(nn1-c1ccccc1)C(=O)N1CCNC(=O)C1)-c1ccccn1 InChI=1S/C26H20Cl2N6O3/c27-19-13-20(28)18(12-17(19)21-8-4-5-9-29-21)25(36)31-23-14-22(26(37)33-11-10-30-24(35)15-33)32-34(23)16-6-2-1-3-7-16/h1-9,12-14H,10-11,15H2,(H,30,35)(H,31,36) PFLGRCCASVKTBE-UHFFFAOYSA-N 226920 US9328096, 608 High affinity nerve growth factor receptor [441-796] Human 34.8 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226920 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226920&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963061 336294016 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396657 Clc1cc(Cl)c(cc1C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCc1cnccn1)-c1ccccn1 InChI=1S/C27H19Cl2N7O2/c28-21-13-22(29)20(12-19(21)23-8-4-5-9-32-23)26(37)34-25-14-24(35-36(25)18-6-2-1-3-7-18)27(38)33-16-17-15-30-10-11-31-17/h1-15H,16H2,(H,33,38)(H,34,37) QYFXHFSJXCQTDT-UHFFFAOYSA-N 226921 US9328096, 609 High affinity nerve growth factor receptor [441-796] Human 4.98 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226921 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226921&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963062 336294017 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396658 Clc1cc(Cl)c(cc1C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCC1CCC(=O)N1)-c1ccccn1 InChI=1S/C27H22Cl2N6O3/c28-20-13-21(29)19(12-18(20)22-8-4-5-11-30-22)26(37)33-24-14-23(34-35(24)17-6-2-1-3-7-17)27(38)31-15-16-9-10-25(36)32-16/h1-8,11-14,16H,9-10,15H2,(H,31,38)(H,32,36)(H,33,37) XBVXEJGEMHUCQD-UHFFFAOYSA-N 226922 US9328096, 610 High affinity nerve growth factor receptor [441-796] Human 52.1 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226922 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226922&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963063 336294018 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396659 Clc1cc(Cl)c(cc1C(=O)Nc1cc(nn1-c1ccccc1)C(=O)N[C@H]1CCOC1)-c1ccccn1 InChI=1S/C26H21Cl2N5O3/c27-20-13-21(28)19(12-18(20)22-8-4-5-10-29-22)25(34)31-24-14-23(26(35)30-16-9-11-36-15-16)32-33(24)17-6-2-1-3-7-17/h1-8,10,12-14,16H,9,11,15H2,(H,30,35)(H,31,34)/t16-/m0/s1 XPOZQMUBUGEOOP-INIZCTEOSA-N 226923 US9328096, 611 High affinity nerve growth factor receptor [441-796] Human 13.1 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226923 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226923&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963064 336294019 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396660 Clc1cc(Cl)c(cc1C(=O)Nc1cc(nn1-c1ccccc1)C(=O)N[C@@H]1CCOC1)-c1ccccn1 InChI=1S/C26H21Cl2N5O3/c27-20-13-21(28)19(12-18(20)22-8-4-5-10-29-22)25(34)31-24-14-23(26(35)30-16-9-11-36-15-16)32-33(24)17-6-2-1-3-7-17/h1-8,10,12-14,16H,9,11,15H2,(H,30,35)(H,31,34)/t16-/m1/s1 XPOZQMUBUGEOOP-MRXNPFEDSA-N 226924 US9328096, 612 High affinity nerve growth factor receptor [441-796] Human 11.4 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226924 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226924&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963065 336294020 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396661 CC1(COC1)NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C26H21Cl2N5O3/c1-26(14-36-15-26)31-25(35)22-13-23(33(32-22)16-7-3-2-4-8-16)30-24(34)18-11-17(19(27)12-20(18)28)21-9-5-6-10-29-21/h2-13H,14-15H2,1H3,(H,30,34)(H,31,35) ANBUJSSHTBBZEV-UHFFFAOYSA-N 226925 US9328096, 613 High affinity nerve growth factor receptor [441-796] Human 9.09 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226925 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226925&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963066 336294021 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396662 O[C@H]1C[C@H](C1)NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C26H21Cl2N5O3/c27-20-13-21(28)19(12-18(20)22-8-4-5-9-29-22)25(35)31-24-14-23(26(36)30-15-10-17(34)11-15)32-33(24)16-6-2-1-3-7-16/h1-9,12-15,17,34H,10-11H2,(H,30,36)(H,31,35)/t15-,17+ VNMUFZWLOJBHEH-WOVMCDHWSA-N 226926 US9328096, 614 High affinity nerve growth factor receptor [441-796] Human 13.1 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226926 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226926&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963043 336294022 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396663 O[C@H]1CC[C@H](CC1)NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C28H25Cl2N5O3/c29-22-15-23(30)21(14-20(22)24-8-4-5-13-31-24)27(37)33-26-16-25(34-35(26)18-6-2-1-3-7-18)28(38)32-17-9-11-19(36)12-10-17/h1-8,13-17,19,36H,9-12H2,(H,32,38)(H,33,37)/t17-,19+ KUNPKIHGQUCMNB-IZAXUBKRSA-N 226927 US9328096, 615 High affinity nerve growth factor receptor [441-796] Human 7.23 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226927 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226927&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 121297534 336294023 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396664 O[C@@H]1COCC[C@H]1NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C27H23Cl2N5O4/c28-19-13-20(29)18(12-17(19)21-8-4-5-10-30-21)26(36)32-25-14-23(33-34(25)16-6-2-1-3-7-16)27(37)31-22-9-11-38-15-24(22)35/h1-8,10,12-14,22,24,35H,9,11,15H2,(H,31,37)(H,32,36)/t22-,24-/m1/s1 MXFZASHNCRWSPB-ISKFKSNPSA-N 226928 US9328096, 616 High affinity nerve growth factor receptor [441-796] Human 16 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226928 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226928&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963067 336294024 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396665 Nc1cc(CNC(=O)c2cc(NC(=O)c3cc(c(Cl)cc3Cl)-c3ccccn3)n(n2)-c2ccccc2)ccn1 InChI=1S/C28H21Cl2N7O2/c29-21-14-22(30)20(13-19(21)23-8-4-5-10-32-23)27(38)35-26-15-24(36-37(26)18-6-2-1-3-7-18)28(39)34-16-17-9-11-33-25(31)12-17/h1-15H,16H2,(H2,31,33)(H,34,39)(H,35,38) FJAXVBYXGQEASX-UHFFFAOYSA-N 226929 US9328096, 617 High affinity nerve growth factor receptor [441-796] Human 1.17 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226929 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226929&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963068 336294025 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396666 OCCC1(COC1)NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C27H23Cl2N5O4/c28-20-13-21(29)19(12-18(20)22-8-4-5-10-30-22)25(36)31-24-14-23(33-34(24)17-6-2-1-3-7-17)26(37)32-27(9-11-35)15-38-16-27/h1-8,10,12-14,35H,9,11,15-16H2,(H,31,36)(H,32,37) MOUVNTOZIZWLGL-UHFFFAOYSA-N 226930 US9328096, 618 High affinity nerve growth factor receptor [441-796] Human 13.7 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226930 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226930&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963069 336294026 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396667 CN1CC(C1)NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C26H22Cl2N6O2/c1-33-14-16(15-33)30-26(36)23-13-24(34(32-23)17-7-3-2-4-8-17)31-25(35)19-11-18(20(27)12-21(19)28)22-9-5-6-10-29-22/h2-13,16H,14-15H2,1H3,(H,30,36)(H,31,35) SRMUWTBUMBJNBW-UHFFFAOYSA-N 226931 US9328096, 619 High affinity nerve growth factor receptor [441-796] Human 44.4 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226931 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226931&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963070 336294027 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396668 COC[C@H](CO)NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C26H23Cl2N5O4/c1-37-15-16(14-34)30-26(36)23-13-24(33(32-23)17-7-3-2-4-8-17)31-25(35)19-11-18(20(27)12-21(19)28)22-9-5-6-10-29-22/h2-13,16,34H,14-15H2,1H3,(H,30,36)(H,31,35)/t16-/m0/s1 CIHGEGBFGOQPMX-INIZCTEOSA-N 226932 US9328096, 620 High affinity nerve growth factor receptor [441-796] Human 20.4 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226932 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226932&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963071 336294028 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396669 Cc1ncc(CNC(=O)c2cc(NC(=O)c3cc(c(Cl)cc3Cl)-c3ccccn3)n(n2)-c2ccccc2)[nH]1 InChI=1S/C27H21Cl2N7O2/c1-16-31-14-17(33-16)15-32-27(38)24-13-25(36(35-24)18-7-3-2-4-8-18)34-26(37)20-11-19(21(28)12-22(20)29)23-9-5-6-10-30-23/h2-14H,15H2,1H3,(H,31,33)(H,32,38)(H,34,37) HDIINVJUQLZHBO-UHFFFAOYSA-N 226933 US9328096, 621 High affinity nerve growth factor receptor [441-796] Human 9.36 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226933 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226933&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963072 336294029 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396670 COC[C@@H](CO)NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C26H23Cl2N5O4/c1-37-15-16(14-34)30-26(36)23-13-24(33(32-23)17-7-3-2-4-8-17)31-25(35)19-11-18(20(27)12-21(19)28)22-9-5-6-10-29-22/h2-13,16,34H,14-15H2,1H3,(H,30,36)(H,31,35)/t16-/m1/s1 CIHGEGBFGOQPMX-MRXNPFEDSA-N 226934 US9328096, 622 High affinity nerve growth factor receptor [441-796] Human 13.2 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226934 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226934&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963073 336294030 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396671 Cn1cc(CNC(=O)c2cc(NC(=O)c3cc(c(Cl)cc3Cl)-c3ccccn3)n(n2)-c2ccccc2)cn1 InChI=1S/C27H21Cl2N7O2/c1-35-16-17(15-32-35)14-31-27(38)24-13-25(36(34-24)18-7-3-2-4-8-18)33-26(37)20-11-19(21(28)12-22(20)29)23-9-5-6-10-30-23/h2-13,15-16H,14H2,1H3,(H,31,38)(H,33,37) IHKWAOUYYAIXED-UHFFFAOYSA-N 226935 US9328096, 623 High affinity nerve growth factor receptor [441-796] Human 8.23 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226935 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226935&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963074 336294031 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396672 Clc1cc(Cl)c(cc1C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCc1ccon1)-c1ccccn1 InChI=1S/C26H18Cl2N6O3/c27-20-13-21(28)19(12-18(20)22-8-4-5-10-29-22)25(35)31-24-14-23(26(36)30-15-16-9-11-37-33-16)32-34(24)17-6-2-1-3-7-17/h1-14H,15H2,(H,30,36)(H,31,35) AVJLUHHXTHQDSS-UHFFFAOYSA-N 226936 US9328096, 624 High affinity nerve growth factor receptor [441-796] Human 8.34 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226936 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226936&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963075 336294032 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396673 Cc1n[nH]c(CNC(=O)c2cc(NC(=O)c3cc(c(Cl)cc3Cl)-c3ccccn3)n(n2)-c2ccccc2)n1 InChI=1S/C26H20Cl2N8O2/c1-15-31-23(34-33-15)14-30-26(38)22-13-24(36(35-22)16-7-3-2-4-8-16)32-25(37)18-11-17(19(27)12-20(18)28)21-9-5-6-10-29-21/h2-13H,14H2,1H3,(H,30,38)(H,32,37)(H,31,33,34) RAUHTEAKIHUBML-UHFFFAOYSA-N 226937 US9328096, 625 High affinity nerve growth factor receptor [441-796] Human 14.6 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226937 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226937&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963076 336294033 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396674 Clc1cc(Cl)c(cc1C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCc1cnco1)-c1ccccn1 InChI=1S/C26H18Cl2N6O3/c27-20-11-21(28)19(10-18(20)22-8-4-5-9-30-22)25(35)32-24-12-23(26(36)31-14-17-13-29-15-37-17)33-34(24)16-6-2-1-3-7-16/h1-13,15H,14H2,(H,31,36)(H,32,35) MZCNZAJTQVOWMD-UHFFFAOYSA-N 226938 US9328096, 626 High affinity nerve growth factor receptor [441-796] Human 6.82 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226938 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226938&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963077 336294034 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396675 O[C@H]1COC[C@@H]1NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C26H21Cl2N5O4/c27-18-11-19(28)17(10-16(18)20-8-4-5-9-29-20)25(35)31-24-12-21(26(36)30-22-13-37-14-23(22)34)32-33(24)15-6-2-1-3-7-15/h1-12,22-23,34H,13-14H2,(H,30,36)(H,31,35)/t22-,23-/m0/s1 UFTQWQVOZWPVKL-GOTSBHOMSA-N 226939 US9328096, 627 High affinity nerve growth factor receptor [441-796] Human 11.4 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226939 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226939&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963078 336294035 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396676 Fc1cc(Cl)c(cc1-c1ccccn1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCc1ccccn1 InChI=1S/C28H20ClFN6O2/c29-22-15-23(30)21(24-11-5-7-13-32-24)14-20(22)27(37)34-26-16-25(35-36(26)19-9-2-1-3-10-19)28(38)33-17-18-8-4-6-12-31-18/h1-16H,17H2,(H,33,38)(H,34,37) FTCJMYQBXOAUEL-UHFFFAOYSA-N 226940 US9328096, 628 High affinity nerve growth factor receptor [441-796] Human 19.4 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226940 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226940&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963079 336294036 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396677 Cc1n[nH]c(CNC(=O)c2cc(NC(=O)c3cc(c(F)cc3Cl)-c3ccccn3)n(n2)-c2ccccc2)n1 InChI=1S/C26H20ClFN8O2/c1-15-31-23(34-33-15)14-30-26(38)22-13-24(36(35-22)16-7-3-2-4-8-16)32-25(37)17-11-18(20(28)12-19(17)27)21-9-5-6-10-29-21/h2-13H,14H2,1H3,(H,30,38)(H,32,37)(H,31,33,34) RXSUMFVRWUZQGO-UHFFFAOYSA-N 226941 US9328096, 629 High affinity nerve growth factor receptor [441-796] Human 34.5 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226941 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226941&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963080 336294037 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396678 CC1(O)CN(C1)C(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C26H21ClFN5O3/c1-26(36)14-32(15-26)25(35)22-13-23(33(31-22)16-7-3-2-4-8-16)30-24(34)17-11-18(20(28)12-19(17)27)21-9-5-6-10-29-21/h2-13,36H,14-15H2,1H3,(H,30,34) MIRIIDOUSGLPSY-UHFFFAOYSA-N 226942 US9328096, 630 High affinity nerve growth factor receptor [441-796] Human 62.5 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226942 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226942&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963081 336294038 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396679 NC(=O)C1CCN(C1)C(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C27H22ClFN6O3/c28-20-13-21(29)19(22-8-4-5-10-31-22)12-18(20)26(37)32-24-14-23(33-35(24)17-6-2-1-3-7-17)27(38)34-11-9-16(15-34)25(30)36/h1-8,10,12-14,16H,9,11,15H2,(H2,30,36)(H,32,37) ZGGZRCATCCXZMF-UHFFFAOYSA-N 226943 US9328096, 631 High affinity nerve growth factor receptor [441-796] Human 114 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226943 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226943&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963082 336294039 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396680 O[C@H]1COC[C@@H]1NC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C26H21ClFN5O4/c27-18-11-19(28)17(20-8-4-5-9-29-20)10-16(18)25(35)31-24-12-21(26(36)30-22-13-37-14-23(22)34)32-33(24)15-6-2-1-3-7-15/h1-12,22-23,34H,13-14H2,(H,30,36)(H,31,35)/t22-,23-/m0/s1 HOGJVCQYWDYRBI-GOTSBHOMSA-N 226944 US9328096, 632 High affinity nerve growth factor receptor [441-796] Human 27.6 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226944 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226944&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963083 336294040 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396681 Fc1cc(Cl)c(cc1-c1ccccn1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NC1CCOCC1 InChI=1S/C27H23ClFN5O3/c28-21-15-22(29)20(23-8-4-5-11-30-23)14-19(21)26(35)32-25-16-24(27(36)31-17-9-12-37-13-10-17)33-34(25)18-6-2-1-3-7-18/h1-8,11,14-17H,9-10,12-13H2,(H,31,36)(H,32,35) UITCTAFFBXSCPU-UHFFFAOYSA-N 226945 US9328096, 633 High affinity nerve growth factor receptor [441-796] Human 33.9 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226945 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226945&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963084 336294041 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396682 OC1(CNC(=O)c2cc(NC(=O)c3cc(c(F)cc3Cl)-c3ccccn3)n(n2)-c2ccccc2)CC1 InChI=1S/C26H21ClFN5O3/c27-19-13-20(28)18(21-8-4-5-11-29-21)12-17(19)24(34)31-23-14-22(25(35)30-15-26(36)9-10-26)32-33(23)16-6-2-1-3-7-16/h1-8,11-14,36H,9-10,15H2,(H,30,35)(H,31,34) NTTMRAGVKPGFRP-UHFFFAOYSA-N 226946 US9328096, 634 High affinity nerve growth factor receptor [441-796] Human 25.5 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226946 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226946&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963085 336294042 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396683 Fc1cc(Cl)c(cc1-c1ccccn1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCc1cccnn1 InChI=1S/C27H19ClFN7O2/c28-21-14-22(29)20(23-10-4-5-11-30-23)13-19(21)26(37)33-25-15-24(35-36(25)18-8-2-1-3-9-18)27(38)31-16-17-7-6-12-32-34-17/h1-15H,16H2,(H,31,38)(H,33,37) RYVHDDFNOMCVBN-UHFFFAOYSA-N 226947 US9328096, 635 High affinity nerve growth factor receptor [441-796] Human 17.7 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226947 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226947&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963086 336294043 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396684 Fc1cc(Cl)c(cc1-c1ccccn1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCC1CCC(=O)N1 InChI=1S/C27H22ClFN6O3/c28-20-13-21(29)19(22-8-4-5-11-30-22)12-18(20)26(37)33-24-14-23(34-35(24)17-6-2-1-3-7-17)27(38)31-15-16-9-10-25(36)32-16/h1-8,11-14,16H,9-10,15H2,(H,31,38)(H,32,36)(H,33,37) YDODBHOFHLAVLE-UHFFFAOYSA-N 226948 US9328096, 636 High affinity nerve growth factor receptor [441-796] Human 95.4 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226948 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226948&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963087 336294044 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396685 OCC1(COC1)NC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C26H21ClFN5O4/c27-19-11-20(28)18(21-8-4-5-9-29-21)10-17(19)24(35)30-23-12-22(25(36)31-26(13-34)14-37-15-26)32-33(23)16-6-2-1-3-7-16/h1-12,34H,13-15H2,(H,30,35)(H,31,36) APOWTTNLDFRXGI-UHFFFAOYSA-N 226949 US9328096, 637 High affinity nerve growth factor receptor [441-796] Human 52.3 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226949 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226949&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963088 336294045 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396686 Fc1cc(Cl)c(cc1-c1ccccn1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)N1CCNC(=O)C1 InChI=1S/C26H20ClFN6O3/c27-19-13-20(28)18(21-8-4-5-9-29-21)12-17(19)25(36)31-23-14-22(26(37)33-11-10-30-24(35)15-33)32-34(23)16-6-2-1-3-7-16/h1-9,12-14H,10-11,15H2,(H,30,35)(H,31,36) BYYFQADPHHOOTA-UHFFFAOYSA-N 226950 US9328096, 638 High affinity nerve growth factor receptor [441-796] Human 67.2 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226950 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226950&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963089 336294046 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396687 COCCNC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C25H21ClFN5O3/c1-35-12-11-29-25(34)22-15-23(32(31-22)16-7-3-2-4-8-16)30-24(33)17-13-18(20(27)14-19(17)26)21-9-5-6-10-28-21/h2-10,13-15H,11-12H2,1H3,(H,29,34)(H,30,33) KNHZFBATOYOUTM-UHFFFAOYSA-N 226951 US9328096, 639 High affinity nerve growth factor receptor [441-796] Human 38.8 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226951 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226951&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963090 336294047 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396688 Fc1cc(Cl)c(cc1-c1ccccn1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCc1ccncn1 InChI=1S/C27H19ClFN7O2/c28-21-13-22(29)20(23-8-4-5-10-31-23)12-19(21)26(37)34-25-14-24(35-36(25)18-6-2-1-3-7-18)27(38)32-15-17-9-11-30-16-33-17/h1-14,16H,15H2,(H,32,38)(H,34,37) XMFQUJAUUFRPQU-UHFFFAOYSA-N 226952 US9328096, 640 High affinity nerve growth factor receptor [441-796] Human 21.2 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226952 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226952&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963091 336294048 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396689 Fc1cc(Cl)c(cc1-c1ccccn1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCCn1ccnn1 InChI=1S/C26H20ClFN8O2/c27-20-15-21(28)19(22-8-4-5-9-29-22)14-18(20)25(37)32-24-16-23(33-36(24)17-6-2-1-3-7-17)26(38)30-10-12-35-13-11-31-34-35/h1-9,11,13-16H,10,12H2,(H,30,38)(H,32,37) JYWFGBUDRIURPB-UHFFFAOYSA-N 226953 US9328096, 641 High affinity nerve growth factor receptor [441-796] Human 36.3 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226953 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226953&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963092 336294049 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396690 NC(=O)[C@H]1CCCN(C1)C(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C28H24ClFN6O3/c29-21-14-22(30)20(23-10-4-5-11-32-23)13-19(21)27(38)33-25-15-24(34-36(25)18-8-2-1-3-9-18)28(39)35-12-6-7-17(16-35)26(31)37/h1-5,8-11,13-15,17H,6-7,12,16H2,(H2,31,37)(H,33,38)/t17-/m0/s1 VDVQERDBADWRKJ-KRWDZBQOSA-N 226954 US9328096, 642 High affinity nerve growth factor receptor [441-796] Human 55.6 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226954 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226954&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963093 336294050 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396691 CC(CO)NC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C25H21ClFN5O3/c1-15(14-33)29-25(35)22-13-23(32(31-22)16-7-3-2-4-8-16)30-24(34)17-11-18(20(27)12-19(17)26)21-9-5-6-10-28-21/h2-13,15,33H,14H2,1H3,(H,29,35)(H,30,34) NTRAKVAAPWCRRE-UHFFFAOYSA-N 226955 US9328096, 643 High affinity nerve growth factor receptor [441-796] Human 28.7 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226955 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226955&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963094 336294051 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396692 CC1(COC1)NC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C26H21ClFN5O3/c1-26(14-36-15-26)31-25(35)22-13-23(33(32-22)16-7-3-2-4-8-16)30-24(34)17-11-18(20(28)12-19(17)27)21-9-5-6-10-29-21/h2-13H,14-15H2,1H3,(H,30,34)(H,31,35) INIYQGVHEXLLDT-UHFFFAOYSA-N 226956 US9328096, 644 High affinity nerve growth factor receptor [441-796] Human 31 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226956 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226956&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963095 336294052 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396693 C[C@@H](CO)NC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C25H21ClFN5O3/c1-15(14-33)29-25(35)22-13-23(32(31-22)16-7-3-2-4-8-16)30-24(34)17-11-18(20(27)12-19(17)26)21-9-5-6-10-28-21/h2-13,15,33H,14H2,1H3,(H,29,35)(H,30,34)/t15-/m0/s1 NTRAKVAAPWCRRE-HNNXBMFYSA-N 226957 US9328096, 645 High affinity nerve growth factor receptor [441-796] Human 24.7 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226957 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226957&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963096 336294053 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396694 Fc1cc(Cl)c(cc1-c1ccccn1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCc1cnccn1 InChI=1S/C27H19ClFN7O2/c28-21-13-22(29)20(23-8-4-5-9-32-23)12-19(21)26(37)34-25-14-24(35-36(25)18-6-2-1-3-7-18)27(38)33-16-17-15-30-10-11-31-17/h1-15H,16H2,(H,33,38)(H,34,37) IPFUGPPZEBHPQP-UHFFFAOYSA-N 226958 US9328096, 646 High affinity nerve growth factor receptor [441-796] Human 11.9 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226958 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226958&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963097 336294054 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396695 Fc1cc(Cl)c(cc1-c1ccccn1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)Nc1nc[nH]n1 InChI=1S/C24H16ClFN8O2/c25-17-11-18(26)16(19-8-4-5-9-27-19)10-15(17)22(35)30-21-12-20(23(36)31-24-28-13-29-32-24)33-34(21)14-6-2-1-3-7-14/h1-13H,(H,30,35)(H2,28,29,31,32,36) QYJBDZNWCFVGKV-UHFFFAOYSA-N 226959 US9328096, 647 High affinity nerve growth factor receptor [441-796] Human 19.4 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226959 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226959&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963098 336294055 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396696 OCCC1(COC1)NC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C27H23ClFN5O4/c28-20-13-21(29)19(22-8-4-5-10-30-22)12-18(20)25(36)31-24-14-23(33-34(24)17-6-2-1-3-7-17)26(37)32-27(9-11-35)15-38-16-27/h1-8,10,12-14,35H,9,11,15-16H2,(H,31,36)(H,32,37) BRQSEEDNXVVCJH-UHFFFAOYSA-N 226960 US9328096, 648 High affinity nerve growth factor receptor [441-796] Human 31.4 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226960 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226960&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963099 336294056 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396697 COC[C@@H](CO)NC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C26H23ClFN5O4/c1-37-15-16(14-34)30-26(36)23-13-24(33(32-23)17-7-3-2-4-8-17)31-25(35)18-11-19(21(28)12-20(18)27)22-9-5-6-10-29-22/h2-13,16,34H,14-15H2,1H3,(H,30,36)(H,31,35)/t16-/m1/s1 TUFOAFAHENLMHP-MRXNPFEDSA-N 226961 US9328096, 649 High affinity nerve growth factor receptor [441-796] Human 41.1 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226961 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226961&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963100 336294057 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396698 O[C@@H]1COCC[C@H]1NC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C27H23ClFN5O4/c28-19-13-20(29)18(21-8-4-5-10-30-21)12-17(19)26(36)32-25-14-23(33-34(25)16-6-2-1-3-7-16)27(37)31-22-9-11-38-15-24(22)35/h1-8,10,12-14,22,24,35H,9,11,15H2,(H,31,37)(H,32,36)/t22-,24-/m1/s1 LBKCZXDVAUBHJY-ISKFKSNPSA-N 226962 US9328096, 650 High affinity nerve growth factor receptor [441-796] Human 40.6 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226962 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226962&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963101 336294058 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396699 OC1CN(C1)C(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C25H19ClFN5O3/c26-19-11-20(27)18(21-8-4-5-9-28-21)10-17(19)24(34)29-23-12-22(25(35)31-13-16(33)14-31)30-32(23)15-6-2-1-3-7-15/h1-12,16,33H,13-14H2,(H,29,34) XFMGFGKMNVYEIY-UHFFFAOYSA-N 226963 US9328096, 651 High affinity nerve growth factor receptor [441-796] Human 43.7 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226963 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226963&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963102 336294059 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396700 CCNC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C24H19ClFN5O2/c1-2-27-24(33)21-14-22(31(30-21)15-8-4-3-5-9-15)29-23(32)16-12-17(19(26)13-18(16)25)20-10-6-7-11-28-20/h3-14H,2H2,1H3,(H,27,33)(H,29,32) NPGBNQDUXSWMQP-UHFFFAOYSA-N 226964 US9328096, 652 High affinity nerve growth factor receptor [441-796] Human 19.1 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226964 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226964&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963103 336294060 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396701 Cc1nnc(CNC(=O)c2cc(NC(=O)c3cc(c(F)cc3Cl)-c3ccccn3)n(n2)-c2ccccc2)o1 InChI=1S/C26H19ClFN7O3/c1-15-32-33-24(38-15)14-30-26(37)22-13-23(35(34-22)16-7-3-2-4-8-16)31-25(36)17-11-18(20(28)12-19(17)27)21-9-5-6-10-29-21/h2-13H,14H2,1H3,(H,30,37)(H,31,36) ICPJIKWALPFANE-UHFFFAOYSA-N 226965 US9328096, 653 High affinity nerve growth factor receptor [441-796] Human 28 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226965 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226965&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963104 336294061 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396702 OCC1(CC1)NC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C26H21ClFN5O3/c27-19-13-20(28)18(21-8-4-5-11-29-21)12-17(19)24(35)30-23-14-22(25(36)31-26(15-34)9-10-26)32-33(23)16-6-2-1-3-7-16/h1-8,11-14,34H,9-10,15H2,(H,30,35)(H,31,36) GTHZKMYWXRDYHE-UHFFFAOYSA-N 226966 US9328096, 654 High affinity nerve growth factor receptor [441-796] Human 22 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226966 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226966&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963105 336294062 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396703 COC[C@H](CO)NC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C26H23ClFN5O4/c1-37-15-16(14-34)30-26(36)23-13-24(33(32-23)17-7-3-2-4-8-17)31-25(35)18-11-19(21(28)12-20(18)27)22-9-5-6-10-29-22/h2-13,16,34H,14-15H2,1H3,(H,30,36)(H,31,35)/t16-/m0/s1 TUFOAFAHENLMHP-INIZCTEOSA-N 226967 US9328096, 655 High affinity nerve growth factor receptor [441-796] Human 46.2 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226967 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226967&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963106 336294063 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396704 C[C@H](CO)NC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C25H21ClFN5O3/c1-15(14-33)29-25(35)22-13-23(32(31-22)16-7-3-2-4-8-16)30-24(34)17-11-18(20(27)12-19(17)26)21-9-5-6-10-28-21/h2-13,15,33H,14H2,1H3,(H,29,35)(H,30,34)/t15-/m1/s1 NTRAKVAAPWCRRE-OAHLLOKOSA-N 226968 US9328096, 656 High affinity nerve growth factor receptor [441-796] Human 31.1 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226968 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226968&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963107 336294064 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396705 Fc1cc(Cl)c(cc1-c1ccccn1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCC1COC1 InChI=1S/C26H21ClFN5O3/c27-20-11-21(28)19(22-8-4-5-9-29-22)10-18(20)25(34)31-24-12-23(26(35)30-13-16-14-36-15-16)32-33(24)17-6-2-1-3-7-17/h1-12,16H,13-15H2,(H,30,35)(H,31,34) BSMJCEMBBNOEJQ-UHFFFAOYSA-N 226969 US9328096, 657 High affinity nerve growth factor receptor [441-796] Human 32.3 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226969 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226969&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963108 336294065 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396706 CC(C)(O)CCNC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C27H25ClFN5O3/c1-27(2,37)11-13-31-26(36)23-16-24(34(33-23)17-8-4-3-5-9-17)32-25(35)18-14-19(21(29)15-20(18)28)22-10-6-7-12-30-22/h3-10,12,14-16,37H,11,13H2,1-2H3,(H,31,36)(H,32,35) ITZCGSGSUUYHKW-UHFFFAOYSA-N 226970 US9328096, 658 High affinity nerve growth factor receptor [441-796] Human 34.8 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226970 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226970&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963109 336294066 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396707 Clc1cc(Cl)c(cc1C(=O)Nc1cc(nn1-c1ccccc1)C(=O)N[C@@H]1CCNC1)-c1ccccn1 InChI=1S/C26H22Cl2N6O2/c27-20-13-21(28)19(12-18(20)22-8-4-5-10-30-22)25(35)32-24-14-23(26(36)31-16-9-11-29-15-16)33-34(24)17-6-2-1-3-7-17/h1-8,10,12-14,16,29H,9,11,15H2,(H,31,36)(H,32,35)/t16-/m1/s1 KNNMRCWHWXOIFK-MRXNPFEDSA-N 226971 US9328096, 659 High affinity nerve growth factor receptor [441-796] Human 50.3 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226971 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226971&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963110 336294067 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396708 C[C@H](CN)NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C25H22Cl2N6O2/c1-15(14-28)30-25(35)22-13-23(33(32-22)16-7-3-2-4-8-16)31-24(34)18-11-17(19(26)12-20(18)27)21-9-5-6-10-29-21/h2-13,15H,14,28H2,1H3,(H,30,35)(H,31,34)/t15-/m1/s1 AZLSAGYEKYFZPJ-OAHLLOKOSA-N 226972 US9328096, 660 High affinity nerve growth factor receptor [441-796] Human 22.9 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226972 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226972&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963111 336294068 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396709 N[C@@H]1CC[C@H](C1)NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C27H24Cl2N6O2/c28-21-14-22(29)20(13-19(21)23-8-4-5-11-31-23)26(36)33-25-15-24(27(37)32-17-10-9-16(30)12-17)34-35(25)18-6-2-1-3-7-18/h1-8,11,13-17H,9-10,12,30H2,(H,32,37)(H,33,36)/t16-,17-/m1/s1 SRDCQQMIBYLNBL-IAGOWNOFSA-N 226973 US9328096, 661 High affinity nerve growth factor receptor [441-796] Human 102 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226973 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226973&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963112 336294069 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396710 N[C@H]1C[C@H](C1)NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C26H22Cl2N6O2/c27-20-13-21(28)19(12-18(20)22-8-4-5-9-30-22)25(35)32-24-14-23(26(36)31-16-10-15(29)11-16)33-34(24)17-6-2-1-3-7-17/h1-9,12-16H,10-11,29H2,(H,31,36)(H,32,35)/t15-,16+ IAZXKESBKLVYNY-IYBDPMFKSA-N 226974 US9328096, 662 High affinity nerve growth factor receptor [441-796] Human 46.9 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226974 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226974&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963113 336294070 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396711 C[C@H](N)CNC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C25H22Cl2N6O2/c1-15(28)14-30-25(35)22-13-23(33(32-22)16-7-3-2-4-8-16)31-24(34)18-11-17(19(26)12-20(18)27)21-9-5-6-10-29-21/h2-13,15H,14,28H2,1H3,(H,30,35)(H,31,34)/t15-/m0/s1 IBPLOVNWYITYML-HNNXBMFYSA-N 226975 US9328096, 663 High affinity nerve growth factor receptor [441-796] Human 147 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226975 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226975&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963114 336294071 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396712 N[C@H]1C[C@@H](C1)NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C26H22Cl2N6O2/c27-20-13-21(28)19(12-18(20)22-8-4-5-9-30-22)25(35)32-24-14-23(26(36)31-16-10-15(29)11-16)33-34(24)17-6-2-1-3-7-17/h1-9,12-16H,10-11,29H2,(H,31,36)(H,32,35)/t15-,16- IAZXKESBKLVYNY-WKILWMFISA-N 226976 US9328096, 664 High affinity nerve growth factor receptor [441-796] Human 38.1 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226976 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226976&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963113 336294072 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396713 C[C@@H](N)CNC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C25H22Cl2N6O2/c1-15(28)14-30-25(35)22-13-23(33(32-22)16-7-3-2-4-8-16)31-24(34)18-11-17(19(26)12-20(18)27)21-9-5-6-10-29-21/h2-13,15H,14,28H2,1H3,(H,30,35)(H,31,34)/t15-/m1/s1 IBPLOVNWYITYML-OAHLLOKOSA-N 226977 US9328096, 665 High affinity nerve growth factor receptor [441-796] Human 134 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226977 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226977&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963115 336294073 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396714 Clc1cc(Cl)c(cc1C(=O)Nc1cc(nn1-c1ccccc1)C(=O)N[C@H]1CCNC1)-c1ccccn1 InChI=1S/C26H22Cl2N6O2/c27-20-13-21(28)19(12-18(20)22-8-4-5-10-30-22)25(35)32-24-14-23(26(36)31-16-9-11-29-15-16)33-34(24)17-6-2-1-3-7-17/h1-8,10,12-14,16,29H,9,11,15H2,(H,31,36)(H,32,35)/t16-/m0/s1 KNNMRCWHWXOIFK-INIZCTEOSA-N 226978 US9328096, 666 High affinity nerve growth factor receptor [441-796] Human 96.1 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226978 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226978&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963116 336294074 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396715 C[C@@H](CN)NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C25H22Cl2N6O2/c1-15(14-28)30-25(35)22-13-23(33(32-22)16-7-3-2-4-8-16)31-24(34)18-11-17(19(26)12-20(18)27)21-9-5-6-10-29-21/h2-13,15H,14,28H2,1H3,(H,30,35)(H,31,34)/t15-/m0/s1 AZLSAGYEKYFZPJ-HNNXBMFYSA-N 226979 US9328096, 667 High affinity nerve growth factor receptor [441-796] Human 172 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226979 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226979&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963117 336294075 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396716 NCCCNC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C25H22Cl2N6O2/c26-19-14-20(27)18(13-17(19)21-9-4-5-11-29-21)24(34)31-23-15-22(25(35)30-12-6-10-28)32-33(23)16-7-2-1-3-8-16/h1-5,7-9,11,13-15H,6,10,12,28H2,(H,30,35)(H,31,34) XPTSWZOFWLZHIZ-UHFFFAOYSA-N 226980 US9328096, 668 High affinity nerve growth factor receptor [441-796] Human 21.6 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226980 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226980&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963118 336294076 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396717 CNCCNC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C25H22Cl2N6O2/c1-28-11-12-30-25(35)22-15-23(33(32-22)16-7-3-2-4-8-16)31-24(34)18-13-17(19(26)14-20(18)27)21-9-5-6-10-29-21/h2-10,13-15,28H,11-12H2,1H3,(H,30,35)(H,31,34) HANNMDSJKKQVTE-UHFFFAOYSA-N 226981 US9328096, 669 High affinity nerve growth factor receptor [441-796] Human 120 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226981 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226981&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963119 336294077 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396718 CN(CCN)C(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C25H22Cl2N6O2/c1-32(12-10-28)25(35)22-15-23(33(31-22)16-7-3-2-4-8-16)30-24(34)18-13-17(19(26)14-20(18)27)21-9-5-6-11-29-21/h2-9,11,13-15H,10,12,28H2,1H3,(H,30,34) ZQZVHMOTRJZHPL-UHFFFAOYSA-N 226982 US9328096, 670 High affinity nerve growth factor receptor [441-796] Human 130 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226982 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226982&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963120 336294078 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396719 Fc1cc(Cl)c(cc1-c1ccccn1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)N[C@@H]1CNC(=O)C1 InChI=1S/C26H20ClFN6O3/c27-19-12-20(28)18(21-8-4-5-9-29-21)11-17(19)25(36)32-23-13-22(26(37)31-15-10-24(35)30-14-15)33-34(23)16-6-2-1-3-7-16/h1-9,11-13,15H,10,14H2,(H,30,35)(H,31,37)(H,32,36)/t15-/m0/s1 JDBIJDIQDSSLDX-HNNXBMFYSA-N 226983 US9328096, 671 High affinity nerve growth factor receptor [441-796] Human 164 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226983 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226983&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963121 336294079 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396720 COc1ccc(CNC(=O)c2cc(NC(=O)c3cc(c(F)cc3Cl)-c3ccccn3)n(n2)-c2ccccc2)nc1 InChI=1S/C29H22ClFN6O3/c1-40-20-11-10-18(33-17-20)16-34-29(39)26-15-27(37(36-26)19-7-3-2-4-8-19)35-28(38)21-13-22(24(31)14-23(21)30)25-9-5-6-12-32-25/h2-15,17H,16H2,1H3,(H,34,39)(H,35,38) SUOWDJCVMOLRDU-UHFFFAOYSA-N 226984 US9328096, 672 High affinity nerve growth factor receptor [441-796] Human 32.7 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226984 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226984&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963122 336294080 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396721 Fc1cc(Cl)c(cc1-c1ccccn1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCCN1CCOC1=O InChI=1S/C27H22ClFN6O4/c28-20-15-21(29)19(22-8-4-5-9-30-22)14-18(20)25(36)32-24-16-23(33-35(24)17-6-2-1-3-7-17)26(37)31-10-11-34-12-13-39-27(34)38/h1-9,14-16H,10-13H2,(H,31,37)(H,32,36) SGHIEYBQAXPXHC-UHFFFAOYSA-N 226985 US9328096, 673 High affinity nerve growth factor receptor [441-796] Human 56.5 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226985 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226985&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963123 336294081 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396722 CNc1ncccc1CNC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C29H23ClFN7O2/c1-32-27-18(8-7-13-34-27)17-35-29(40)25-16-26(38(37-25)19-9-3-2-4-10-19)36-28(39)20-14-21(23(31)15-22(20)30)24-11-5-6-12-33-24/h2-16H,17H2,1H3,(H,32,34)(H,35,40)(H,36,39) CWZULMFAMKAUGK-UHFFFAOYSA-N 226986 US9328096, 674 High affinity nerve growth factor receptor [441-796] Human 9.98 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226986 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226986&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963124 336294082 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396723 Fc1cc(Cl)c(cc1-c1ccccn1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCCN1CCNC1=O InChI=1S/C27H23ClFN7O3/c28-20-15-21(29)19(22-8-4-5-9-30-22)14-18(20)25(37)33-24-16-23(34-36(24)17-6-2-1-3-7-17)26(38)31-10-12-35-13-11-32-27(35)39/h1-9,14-16H,10-13H2,(H,31,38)(H,32,39)(H,33,37) YQNXISNDGLCMGC-UHFFFAOYSA-N 226987 US9328096, 675 High affinity nerve growth factor receptor [441-796] Human 179 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226987 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226987&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963125 336294083 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396724 COc1ccc(CNC(=O)c2cc(NC(=O)c3cc(c(F)cc3Cl)-c3ccccn3)n(n2)-c2ccccc2)cn1 InChI=1S/C29H22ClFN6O3/c1-40-27-11-10-18(16-33-27)17-34-29(39)25-15-26(37(36-25)19-7-3-2-4-8-19)35-28(38)20-13-21(23(31)14-22(20)30)24-9-5-6-12-32-24/h2-16H,17H2,1H3,(H,34,39)(H,35,38) LJHNLXCCBZJTDT-UHFFFAOYSA-N 226988 US9328096, 676 High affinity nerve growth factor receptor [441-796] Human 27.5 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226988 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226988&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963126 336294084 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396725 Cn1c(O)nnc1CNC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C26H20ClFN8O3/c1-35-23(32-33-26(35)39)14-30-25(38)21-13-22(36(34-21)15-7-3-2-4-8-15)31-24(37)16-11-17(19(28)12-18(16)27)20-9-5-6-10-29-20/h2-13H,14H2,1H3,(H,30,38)(H,31,37)(H,33,39) UPWLAPUHZKDIMX-UHFFFAOYSA-N 226989 US9328096, 677 High affinity nerve growth factor receptor [441-796] Human 156 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226989 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226989&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963127 336294085 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396726 Oc1cc(CNC(=O)c2cc(NC(=O)c3cc(c(F)cc3Cl)-c3ccccn3)n(n2)-c2ccccc2)on1 InChI=1S/C26H18ClFN6O4/c27-19-12-20(28)18(21-8-4-5-9-29-21)11-17(19)25(36)31-23-13-22(32-34(23)15-6-2-1-3-7-15)26(37)30-14-16-10-24(35)33-38-16/h1-13H,14H2,(H,30,37)(H,31,36)(H,33,35) WURJLARCSILLJY-UHFFFAOYSA-N 226990 US9328096, 678 High affinity nerve growth factor receptor [441-796] Human 125 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226990 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226990&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963128 336294086 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396727 COCc1cc(CNC(=O)c2cc(NC(=O)c3cc(c(F)cc3Cl)-c3ccccn3)n(n2)-c2ccccc2)n[nH]1 InChI=1S/C28H23ClFN7O3/c1-40-16-18-11-17(34-35-18)15-32-28(39)25-14-26(37(36-25)19-7-3-2-4-8-19)33-27(38)20-12-21(23(30)13-22(20)29)24-9-5-6-10-31-24/h2-14H,15-16H2,1H3,(H,32,39)(H,33,38)(H,34,35) CALNDFKYCRNEKA-UHFFFAOYSA-N 226991 US9328096, 679 High affinity nerve growth factor receptor [441-796] Human 21.1 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226991 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226991&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963129 336294087 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396728 Cc1ccc(CNC(=O)c2cc(NC(=O)c3cc(c(F)cc3Cl)-c3ccccn3)n(n2)-c2ccccc2)c(N)n1 InChI=1S/C29H23ClFN7O2/c1-17-10-11-18(27(32)35-17)16-34-29(40)25-15-26(38(37-25)19-7-3-2-4-8-19)36-28(39)20-13-21(23(31)14-22(20)30)24-9-5-6-12-33-24/h2-15H,16H2,1H3,(H2,32,35)(H,34,40)(H,36,39) KCYWNKUYMDHRKO-UHFFFAOYSA-N 226992 US9328096, 680 High affinity nerve growth factor receptor [441-796] Human 2.65 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226992 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226992&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963130 336294088 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396729 CC(=O)N1CCC(CC1)NC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C29H26ClFN6O3/c1-18(38)36-13-10-19(11-14-36)33-29(40)26-17-27(37(35-26)20-7-3-2-4-8-20)34-28(39)21-15-22(24(31)16-23(21)30)25-9-5-6-12-32-25/h2-9,12,15-17,19H,10-11,13-14H2,1H3,(H,33,40)(H,34,39) JTVXYLCTGCOSBH-UHFFFAOYSA-N 226993 US9328096, 681 High affinity nerve growth factor receptor [441-796] Human 61.3 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226993 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226993&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963131 336294089 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396730 COc1cccnc1CNC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C29H22ClFN6O3/c1-40-26-11-7-13-33-25(26)17-34-29(39)24-16-27(37(36-24)18-8-3-2-4-9-18)35-28(38)19-14-20(22(31)15-21(19)30)23-10-5-6-12-32-23/h2-16H,17H2,1H3,(H,34,39)(H,35,38) QIYWRCMZQNDOBE-UHFFFAOYSA-N 226994 US9328096, 682 High affinity nerve growth factor receptor [441-796] Human 95.8 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226994 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226994&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963132 336294090 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396731 CN1CC2CN(CC2C1)C(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C29H26ClFN6O2/c1-35-14-18-16-36(17-19(18)15-35)29(39)26-13-27(37(34-26)20-7-3-2-4-8-20)33-28(38)21-11-22(24(31)12-23(21)30)25-9-5-6-10-32-25/h2-13,18-19H,14-17H2,1H3,(H,33,38) IDWGKKMOMAIPPE-UHFFFAOYSA-N 226995 US9328096, 683 High affinity nerve growth factor receptor [441-796] Human 202 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226995 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226995&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963133 336294091 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396732 Fc1cc(Cl)c(cc1-c1ccccn1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)N1CCN(C2CC2)C(=O)C1 InChI=1S/C29H24ClFN6O3/c30-22-15-23(31)21(24-8-4-5-11-32-24)14-20(22)28(39)33-26-16-25(34-37(26)19-6-2-1-3-7-19)29(40)35-12-13-36(18-9-10-18)27(38)17-35/h1-8,11,14-16,18H,9-10,12-13,17H2,(H,33,39) FRRYODQDMJVGOZ-UHFFFAOYSA-N 226996 US9328096, 684 High affinity nerve growth factor receptor [441-796] Human 104 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226996 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226996&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963134 336294092 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396733 CC(O)CN(CC(C)O)C(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C28H27ClFN5O4/c1-17(36)15-34(16-18(2)37)28(39)25-14-26(35(33-25)19-8-4-3-5-9-19)32-27(38)20-12-21(23(30)13-22(20)29)24-10-6-7-11-31-24/h3-14,17-18,36-37H,15-16H2,1-2H3,(H,32,38) TXRMZECNXMHEDR-UHFFFAOYSA-N 226997 US9328096, 685 High affinity nerve growth factor receptor [441-796] Human 710 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226997 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226997&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963135 336294093 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396734 CNc1ccc(CNC(=O)c2cc(NC(=O)c3cc(c(F)cc3Cl)-c3ccccn3)n(n2)-c2ccccc2)cn1 InChI=1S/C29H23ClFN7O2/c1-32-26-11-10-18(16-34-26)17-35-29(40)25-15-27(38(37-25)19-7-3-2-4-8-19)36-28(39)20-13-21(23(31)14-22(20)30)24-9-5-6-12-33-24/h2-16H,17H2,1H3,(H,32,34)(H,35,40)(H,36,39) WPQBODQCLNKZEH-UHFFFAOYSA-N 226998 US9328096, 686 High affinity nerve growth factor receptor [441-796] Human 1.77 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226998 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226998&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963136 336294094 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396735 Oc1ccc(CNC(=O)c2cc(NC(=O)c3cc(c(F)cc3Cl)-c3ccccn3)n(n2)-c2ccccc2)nc1 InChI=1S/C28H20ClFN6O3/c29-22-13-23(30)21(24-8-4-5-11-31-24)12-20(22)27(38)34-26-14-25(35-36(26)18-6-2-1-3-7-18)28(39)33-15-17-9-10-19(37)16-32-17/h1-14,16,37H,15H2,(H,33,39)(H,34,38) SWILKFWGVKOEON-UHFFFAOYSA-N 226999 US9328096, 687 High affinity nerve growth factor receptor [441-796] Human 2.27 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226999 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226999&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963137 336294095 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396736 COc1cc(CNC(=O)c2cc(NC(=O)c3cc(c(F)cc3Cl)-c3ccccn3)n(n2)-c2ccccc2)ccn1 InChI=1S/C29H22ClFN6O3/c1-40-27-13-18(10-12-33-27)17-34-29(39)25-16-26(37(36-25)19-7-3-2-4-8-19)35-28(38)20-14-21(23(31)15-22(20)30)24-9-5-6-11-32-24/h2-16H,17H2,1H3,(H,34,39)(H,35,38) BSOQKJDPFXRKES-UHFFFAOYSA-N 227000 US9328096, 688 High affinity nerve growth factor receptor [441-796] Human 4.56 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227000 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227000&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963138 336294096 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396737 CN(C1CCN(C1)C(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1)C(C)=O InChI=1S/C29H26ClFN6O3/c1-18(38)35(2)20-11-13-36(17-20)29(40)26-16-27(37(34-26)19-8-4-3-5-9-19)33-28(39)21-14-22(24(31)15-23(21)30)25-10-6-7-12-32-25/h3-10,12,14-16,20H,11,13,17H2,1-2H3,(H,33,39) CVJSSQHIQFGTHZ-UHFFFAOYSA-N 227001 US9328096, 689 High affinity nerve growth factor receptor [441-796] Human 85 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227001 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227001&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963139 336294097 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396738 Oc1cccnc1CNC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C28H20ClFN6O3/c29-20-14-21(30)19(22-9-4-5-11-31-22)13-18(20)27(38)34-26-15-23(35-36(26)17-7-2-1-3-8-17)28(39)33-16-24-25(37)10-6-12-32-24/h1-15,37H,16H2,(H,33,39)(H,34,38) KRQOSTGEIUCMEZ-UHFFFAOYSA-N 227002 US9328096, 690 High affinity nerve growth factor receptor [441-796] Human 14.1 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227002 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227002&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963140 336294098 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396739 CN(C)C(=O)[C@@H]1CCCN1C(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C29H26ClFN6O3/c1-35(2)29(40)25-12-8-14-36(25)28(39)24-17-26(37(34-24)18-9-4-3-5-10-18)33-27(38)19-15-20(22(31)16-21(19)30)23-11-6-7-13-32-23/h3-7,9-11,13,15-17,25H,8,12,14H2,1-2H3,(H,33,38)/t25-/m0/s1 WGLYESNENMONKO-VWLOTQADSA-N 227003 US9328096, 691 High affinity nerve growth factor receptor [441-796] Human 327 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227003 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227003&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963141 336294099 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396740 COc1ccnc(CNC(=O)c2cc(NC(=O)c3cc(c(F)cc3Cl)-c3ccccn3)n(n2)-c2ccccc2)c1 InChI=1S/C29H22ClFN6O3/c1-40-20-10-12-32-18(13-20)17-34-29(39)26-16-27(37(36-26)19-7-3-2-4-8-19)35-28(38)21-14-22(24(31)15-23(21)30)25-9-5-6-11-33-25/h2-16H,17H2,1H3,(H,34,39)(H,35,38) UGRKDFHNTFOQOA-UHFFFAOYSA-N 227004 US9328096, 692 High affinity nerve growth factor receptor [441-796] Human 54.1 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227004 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227004&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963142 336294100 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396741 Nc1cnccc1CNC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C28H21ClFN7O2/c29-21-13-22(30)20(24-8-4-5-10-33-24)12-19(21)27(38)35-26-14-25(36-37(26)18-6-2-1-3-7-18)28(39)34-15-17-9-11-32-16-23(17)31/h1-14,16H,15,31H2,(H,34,39)(H,35,38) FDXXSKLTTLBVQS-UHFFFAOYSA-N 227005 US9328096, 693 High affinity nerve growth factor receptor [441-796] Human 11.8 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227005 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227005&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963143 336294101 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396742 OCc1cccc(CNC(=O)c2cc(NC(=O)c3cc(c(F)cc3Cl)-c3ccccn3)n(n2)-c2ccccc2)n1 InChI=1S/C29H22ClFN6O3/c30-23-14-24(31)22(25-11-4-5-12-32-25)13-21(23)28(39)35-27-15-26(36-37(27)20-9-2-1-3-10-20)29(40)33-16-18-7-6-8-19(17-38)34-18/h1-15,38H,16-17H2,(H,33,40)(H,35,39) WVGMYTKSBGDKLO-UHFFFAOYSA-N 227006 US9328096, 694 High affinity nerve growth factor receptor [441-796] Human 13.8 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227006 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227006&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963144 336294102 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396743 Nc1cccnc1CNC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C28H21ClFN7O2/c29-20-14-21(30)19(23-10-4-5-11-32-23)13-18(20)27(38)35-26-15-24(36-37(26)17-7-2-1-3-8-17)28(39)34-16-25-22(31)9-6-12-33-25/h1-15H,16,31H2,(H,34,39)(H,35,38) ZWTKDNAWOXLBNV-UHFFFAOYSA-N 227007 US9328096, 695 High affinity nerve growth factor receptor [441-796] Human 45.6 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227007 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227007&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963145 336294103 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396744 Fc1cc(Cl)c(cc1-c1ccccn1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)N[C@@H]1CCNC1 InChI=1S/C26H22ClFN6O2/c27-20-13-21(28)19(22-8-4-5-10-30-22)12-18(20)25(35)32-24-14-23(26(36)31-16-9-11-29-15-16)33-34(24)17-6-2-1-3-7-17/h1-8,10,12-14,16,29H,9,11,15H2,(H,31,36)(H,32,35)/t16-/m1/s1 DWXAKNAGHWWCIV-MRXNPFEDSA-N 227008 US9328096, 696 High affinity nerve growth factor receptor [441-796] Human 666 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227008 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227008&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963146 336294104 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396745 C[C@@H](N)CNC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C25H22ClFN6O2/c1-15(28)14-30-25(35)22-13-23(33(32-22)16-7-3-2-4-8-16)31-24(34)17-11-18(20(27)12-19(17)26)21-9-5-6-10-29-21/h2-13,15H,14,28H2,1H3,(H,30,35)(H,31,34)/t15-/m1/s1 ZGONRLXKVKIOFB-OAHLLOKOSA-N 227009 US9328096, 697 High affinity nerve growth factor receptor [441-796] Human 276 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227009 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227009&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963147 336294105 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396746 Fc1cc(Cl)c(cc1-c1ccccn1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NC1CNC1 InChI=1S/C25H20ClFN6O2/c26-19-11-20(27)18(21-8-4-5-9-29-21)10-17(19)24(34)31-23-12-22(25(35)30-15-13-28-14-15)32-33(23)16-6-2-1-3-7-16/h1-12,15,28H,13-14H2,(H,30,35)(H,31,34) ZNSSSJUNIGSBCJ-UHFFFAOYSA-N 227010 US9328096, 698 High affinity nerve growth factor receptor [441-796] Human 2390 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227010 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227010&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963148 336294106 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396747 N[C@@H]1CC[C@H](C1)NC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C27H24ClFN6O2/c28-21-14-22(29)20(23-8-4-5-11-31-23)13-19(21)26(36)33-25-15-24(27(37)32-17-10-9-16(30)12-17)34-35(25)18-6-2-1-3-7-18/h1-8,11,13-17H,9-10,12,30H2,(H,32,37)(H,33,36)/t16-,17-/m1/s1 MIGVQNVEFLTJAT-IAGOWNOFSA-N 227011 US9328096, 699 High affinity nerve growth factor receptor [441-796] Human 277 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227011 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227011&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963149 336294107 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396748 C[C@H](N)CNC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C25H22ClFN6O2/c1-15(28)14-30-25(35)22-13-23(33(32-22)16-7-3-2-4-8-16)31-24(34)17-11-18(20(27)12-19(17)26)21-9-5-6-10-29-21/h2-13,15H,14,28H2,1H3,(H,30,35)(H,31,34)/t15-/m0/s1 ZGONRLXKVKIOFB-HNNXBMFYSA-N 227012 US9328096, 700 High affinity nerve growth factor receptor [441-796] Human 364 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227012 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227012&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963150 336294108 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396749 C[C@H](CN)NC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C25H22ClFN6O2/c1-15(14-28)30-25(35)22-13-23(33(32-22)16-7-3-2-4-8-16)31-24(34)17-11-18(20(27)12-19(17)26)21-9-5-6-10-29-21/h2-13,15H,14,28H2,1H3,(H,30,35)(H,31,34)/t15-/m1/s1 JLLMDYAOOKBGHF-OAHLLOKOSA-N 227013 US9328096, 701 High affinity nerve growth factor receptor [441-796] Human 97.4 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227013 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227013&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963151 336294109 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396750 C[C@@H](CN)NC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C25H22ClFN6O2/c1-15(14-28)30-25(35)22-13-23(33(32-22)16-7-3-2-4-8-16)31-24(34)17-11-18(20(27)12-19(17)26)21-9-5-6-10-29-21/h2-13,15H,14,28H2,1H3,(H,30,35)(H,31,34)/t15-/m0/s1 JLLMDYAOOKBGHF-HNNXBMFYSA-N 227014 US9328096, 702 High affinity nerve growth factor receptor [441-796] Human 326 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227014 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227014&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963152 336294110 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396751 CN(CCN)C(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C25H22ClFN6O2/c1-32(12-10-28)25(35)22-15-23(33(31-22)16-7-3-2-4-8-16)30-24(34)17-13-18(20(27)14-19(17)26)21-9-5-6-11-29-21/h2-9,11,13-15H,10,12,28H2,1H3,(H,30,34) CXMBMNNJJHAYGT-UHFFFAOYSA-N 227015 US9328096, 703 High affinity nerve growth factor receptor [441-796] Human 546 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227015 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227015&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963153 336294111 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396752 CNCCNC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C25H21ClF2N6O2/c1-29-10-11-31-25(36)21-14-22(34(33-21)15-6-3-2-4-7-15)32-24(35)16-12-17(20(28)13-18(16)26)23-19(27)8-5-9-30-23/h2-9,12-14,29H,10-11H2,1H3,(H,31,36)(H,32,35) ZVIDZMXRZQYCOH-UHFFFAOYSA-N 227016 US9328096, 704 High affinity nerve growth factor receptor [441-796] Human 218 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227016 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227016&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963154 336294112 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396753 N[C@H]1C[C@@H](C1)NC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C26H21ClF2N6O2/c27-19-12-21(29)18(24-20(28)7-4-8-31-24)11-17(19)25(36)33-23-13-22(26(37)32-15-9-14(30)10-15)34-35(23)16-5-2-1-3-6-16/h1-8,11-15H,9-10,30H2,(H,32,37)(H,33,36)/t14-,15- GISGUAMXQWKWGW-SHTZXODSSA-N 227017 US9328096, 705 High affinity nerve growth factor receptor [441-796] Human 81.3 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227017&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963155 336294113 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396754 N[C@@H]1CC[C@H](C1)NC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C27H23ClF2N6O2/c28-20-13-22(30)19(25-21(29)7-4-10-32-25)12-18(20)26(37)34-24-14-23(27(38)33-16-9-8-15(31)11-16)35-36(24)17-5-2-1-3-6-17/h1-7,10,12-16H,8-9,11,31H2,(H,33,38)(H,34,37)/t15-,16-/m1/s1 AZUPXHZXENWLDT-HZPDHXFCSA-N 227018 US9328096, 706 High affinity nerve growth factor receptor [441-796] Human 166 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227018 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227018&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963156 336294114 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396755 Fc1cc(Cl)c(cc1-c1ncccc1F)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NC1CNC1 InChI=1S/C25H19ClF2N6O2/c26-18-10-20(28)17(23-19(27)7-4-8-30-23)9-16(18)24(35)32-22-11-21(25(36)31-14-12-29-13-14)33-34(22)15-5-2-1-3-6-15/h1-11,14,29H,12-13H2,(H,31,36)(H,32,35) PPEDOIUVGRPUTF-UHFFFAOYSA-N 227019 US9328096, 707 High affinity nerve growth factor receptor [441-796] Human 891 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227019 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227019&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963157 336294115 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396756 Fc1cccnc1-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)N[C@H]2CCNC2)c(Cl)cc1F InChI=1S/C26H21ClF2N6O2/c27-19-12-21(29)18(24-20(28)7-4-9-31-24)11-17(19)25(36)33-23-13-22(26(37)32-15-8-10-30-14-15)34-35(23)16-5-2-1-3-6-16/h1-7,9,11-13,15,30H,8,10,14H2,(H,32,37)(H,33,36)/t15-/m0/s1 LARFYHZGUHPKJV-HNNXBMFYSA-N 227020 US9328096, 708 High affinity nerve growth factor receptor [441-796] Human 310 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227020 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227020&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963158 336294116 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396757 Fc1cccnc1-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)N[C@@H]2CCNC2)c(Cl)cc1F InChI=1S/C26H21ClF2N6O2/c27-19-12-21(29)18(24-20(28)7-4-9-31-24)11-17(19)25(36)33-23-13-22(26(37)32-15-8-10-30-14-15)34-35(23)16-5-2-1-3-6-16/h1-7,9,11-13,15,30H,8,10,14H2,(H,32,37)(H,33,36)/t15-/m1/s1 LARFYHZGUHPKJV-OAHLLOKOSA-N 227021 US9328096, 709 High affinity nerve growth factor receptor [441-796] Human 158 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227021 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227021&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963159 336294117 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396758 N[C@H]1C[C@H](C1)NC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C26H21ClF2N6O2/c27-19-12-21(29)18(24-20(28)7-4-8-31-24)11-17(19)25(36)33-23-13-22(26(37)32-15-9-14(30)10-15)34-35(23)16-5-2-1-3-6-16/h1-8,11-15H,9-10,30H2,(H,32,37)(H,33,36)/t14-,15+ GISGUAMXQWKWGW-GASCZTMLSA-N 227022 US9328096, 710 High affinity nerve growth factor receptor [441-796] Human 53.1 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227022 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227022&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963155 336294118 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396759 NCCCNC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C25H21ClF2N6O2/c26-18-13-20(28)17(23-19(27)8-4-10-30-23)12-16(18)24(35)32-22-14-21(25(36)31-11-5-9-29)33-34(22)15-6-2-1-3-7-15/h1-4,6-8,10,12-14H,5,9,11,29H2,(H,31,36)(H,32,35) KIEZYVLUQDGWDU-UHFFFAOYSA-N 227023 US9328096, 711 High affinity nerve growth factor receptor [441-796] Human 34.2 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227023 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227023&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963160 336294119 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396760 C[C@H](N)CNC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C25H21ClF2N6O2/c1-14(29)13-31-25(36)21-12-22(34(33-21)15-6-3-2-4-7-15)32-24(35)16-10-17(20(28)11-18(16)26)23-19(27)8-5-9-30-23/h2-12,14H,13,29H2,1H3,(H,31,36)(H,32,35)/t14-/m0/s1 OVHPFIJWCHUHPG-AWEZNQCLSA-N 227024 US9328096, 712 High affinity nerve growth factor receptor [441-796] Human 131 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227024 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227024&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963161 336294120 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396761 C[C@@H](CN)NC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C25H21ClF2N6O2/c1-14(13-29)31-25(36)21-12-22(34(33-21)15-6-3-2-4-7-15)32-24(35)16-10-17(20(28)11-18(16)26)23-19(27)8-5-9-30-23/h2-12,14H,13,29H2,1H3,(H,31,36)(H,32,35)/t14-/m0/s1 FYAABJULMNOBPX-AWEZNQCLSA-N 227025 US9328096, 713 High affinity nerve growth factor receptor [441-796] Human 185 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227025 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227025&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963162 336294121 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396762 C[C@H](CN)NC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C25H21ClF2N6O2/c1-14(13-29)31-25(36)21-12-22(34(33-21)15-6-3-2-4-7-15)32-24(35)16-10-17(20(28)11-18(16)26)23-19(27)8-5-9-30-23/h2-12,14H,13,29H2,1H3,(H,31,36)(H,32,35)/t14-/m1/s1 FYAABJULMNOBPX-CQSZACIVSA-N 227026 US9328096, 714 High affinity nerve growth factor receptor [441-796] Human 37.5 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227026 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227026&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963163 336294122 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396763 C[C@@H](N)CNC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C25H21ClF2N6O2/c1-14(29)13-31-25(36)21-12-22(34(33-21)15-6-3-2-4-7-15)32-24(35)16-10-17(20(28)11-18(16)26)23-19(27)8-5-9-30-23/h2-12,14H,13,29H2,1H3,(H,31,36)(H,32,35)/t14-/m1/s1 OVHPFIJWCHUHPG-CQSZACIVSA-N 227027 US9328096, 715 High affinity nerve growth factor receptor [441-796] Human 113 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227027 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227027&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963164 336294123 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396764 N[C@H]1C[C@@H](C1)NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C26H21Cl2FN6O2/c27-19-12-20(28)18(11-17(19)24-21(29)7-4-8-31-24)25(36)33-23-13-22(26(37)32-15-9-14(30)10-15)34-35(23)16-5-2-1-3-6-16/h1-8,11-15H,9-10,30H2,(H,32,37)(H,33,36)/t14-,15- PTKZQGQKIBHRQW-SHTZXODSSA-N 227028 US9328096, 716 High affinity nerve growth factor receptor [441-796] Human 27.2 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227028 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227028&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963165 336294124 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396765 N[C@@H]1CC[C@H](C1)NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C27H23Cl2FN6O2/c28-20-13-21(29)19(12-18(20)25-22(30)7-4-10-32-25)26(37)34-24-14-23(27(38)33-16-9-8-15(31)11-16)35-36(24)17-5-2-1-3-6-17/h1-7,10,12-16H,8-9,11,31H2,(H,33,38)(H,34,37)/t15-,16-/m1/s1 YAOJBCNQOMXUBU-HZPDHXFCSA-N 227029 US9328096, 717 High affinity nerve growth factor receptor [441-796] Human 75.7 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227029 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227029&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963166 336294125 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396766 C[C@@H](CN)NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C25H21Cl2FN6O2/c1-14(13-29)31-25(36)21-12-22(34(33-21)15-6-3-2-4-7-15)32-24(35)17-10-16(18(26)11-19(17)27)23-20(28)8-5-9-30-23/h2-12,14H,13,29H2,1H3,(H,31,36)(H,32,35)/t14-/m0/s1 DNMVOSXMDOUIHF-AWEZNQCLSA-N 227030 US9328096, 718 High affinity nerve growth factor receptor [441-796] Human 100 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227030 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227030&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963167 336294126 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396767 Fc1cccnc1-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)N[C@@H]2CCNC2)c(Cl)cc1Cl InChI=1S/C26H21Cl2FN6O2/c27-19-12-20(28)18(11-17(19)24-21(29)7-4-9-31-24)25(36)33-23-13-22(26(37)32-15-8-10-30-14-15)34-35(23)16-5-2-1-3-6-16/h1-7,9,11-13,15,30H,8,10,14H2,(H,32,37)(H,33,36)/t15-/m1/s1 GXASSCHOXGNLNX-OAHLLOKOSA-N 227031 US9328096, 719 High affinity nerve growth factor receptor [441-796] Human 26.3 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227031 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227031&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963168 336294127 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396768 NCCCNC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C25H21Cl2FN6O2/c26-18-13-19(27)17(12-16(18)23-20(28)8-4-10-30-23)24(35)32-22-14-21(25(36)31-11-5-9-29)33-34(22)15-6-2-1-3-7-15/h1-4,6-8,10,12-14H,5,9,11,29H2,(H,31,36)(H,32,35) OQAJJUBUUBECAC-UHFFFAOYSA-N 227032 US9328096, 720 High affinity nerve growth factor receptor [441-796] Human 14.4 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227032 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227032&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963169 336294128 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396769 CN(CCN)C(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C25H21Cl2FN6O2/c1-33(11-9-29)25(36)21-14-22(34(32-21)15-6-3-2-4-7-15)31-24(35)17-12-16(18(26)13-19(17)27)23-20(28)8-5-10-30-23/h2-8,10,12-14H,9,11,29H2,1H3,(H,31,35) AJBFIVFRNRWEGN-UHFFFAOYSA-N 227033 US9328096, 721 High affinity nerve growth factor receptor [441-796] Human 79.4 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227033 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227033&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963170 336294129 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396770 N[C@H]1C[C@H](C1)NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C26H21Cl2FN6O2/c27-19-12-20(28)18(11-17(19)24-21(29)7-4-8-31-24)25(36)33-23-13-22(26(37)32-15-9-14(30)10-15)34-35(23)16-5-2-1-3-6-16/h1-8,11-15H,9-10,30H2,(H,32,37)(H,33,36)/t14-,15+ PTKZQGQKIBHRQW-GASCZTMLSA-N 227034 US9328096, 722 High affinity nerve growth factor receptor [441-796] Human 31.5 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227034 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227034&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963165 336294130 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396771 C[C@@H](N)CNC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C25H21Cl2FN6O2/c1-14(29)13-31-25(36)21-12-22(34(33-21)15-6-3-2-4-7-15)32-24(35)17-10-16(18(26)11-19(17)27)23-20(28)8-5-9-30-23/h2-12,14H,13,29H2,1H3,(H,31,36)(H,32,35)/t14-/m1/s1 JEYFYFWJSFFCIS-CQSZACIVSA-N 227035 US9328096, 723 High affinity nerve growth factor receptor [441-796] Human 69 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227035 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227035&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963171 336294131 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396772 C[C@H](N)CNC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C25H21Cl2FN6O2/c1-14(29)13-31-25(36)21-12-22(34(33-21)15-6-3-2-4-7-15)32-24(35)17-10-16(18(26)11-19(17)27)23-20(28)8-5-9-30-23/h2-12,14H,13,29H2,1H3,(H,31,36)(H,32,35)/t14-/m0/s1 JEYFYFWJSFFCIS-AWEZNQCLSA-N 227036 US9328096, 724 High affinity nerve growth factor receptor [441-796] Human 92.8 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227036 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227036&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963172 336294132 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396773 C[C@H](CN)NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C25H21Cl2FN6O2/c1-14(13-29)31-25(36)21-12-22(34(33-21)15-6-3-2-4-7-15)32-24(35)17-10-16(18(26)11-19(17)27)23-20(28)8-5-9-30-23/h2-12,14H,13,29H2,1H3,(H,31,36)(H,32,35)/t14-/m1/s1 DNMVOSXMDOUIHF-CQSZACIVSA-N 227037 US9328096, 725 High affinity nerve growth factor receptor [441-796] Human 12.2 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227037 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227037&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963173 336294133 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396774 CNCCNC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C25H21Cl2FN6O2/c1-29-10-11-31-25(36)21-14-22(34(33-21)15-6-3-2-4-7-15)32-24(35)17-12-16(18(26)13-19(17)27)23-20(28)8-5-9-30-23/h2-9,12-14,29H,10-11H2,1H3,(H,31,36)(H,32,35) PSPXEKLKOWTBHN-UHFFFAOYSA-N 227038 US9328096, 726 High affinity nerve growth factor receptor [441-796] Human 66.8 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227038 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227038&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963174 336294134 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396775 CNCCNC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccc(F)cn2)n(n1)-c1ccccc1 InChI=1S/C25H21Cl2FN6O2/c1-29-9-10-30-25(36)22-13-23(34(33-22)16-5-3-2-4-6-16)32-24(35)18-11-17(19(26)12-20(18)27)21-8-7-15(28)14-31-21/h2-8,11-14,29H,9-10H2,1H3,(H,30,36)(H,32,35) HYGAYMHYKNFYSL-UHFFFAOYSA-N 227039 US9328096, 727 High affinity nerve growth factor receptor [441-796] Human 241 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227039 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227039&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963175 336294135 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396776 Fc1ccc(nc1)-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)NC2CNC2)c(Cl)cc1Cl InChI=1S/C25H19Cl2FN6O2/c26-19-9-20(27)18(8-17(19)21-7-6-14(28)11-30-21)24(35)32-23-10-22(25(36)31-15-12-29-13-15)33-34(23)16-4-2-1-3-5-16/h1-11,15,29H,12-13H2,(H,31,36)(H,32,35) AGINSILAOKAOAY-UHFFFAOYSA-N 227040 US9328096, 728 High affinity nerve growth factor receptor [441-796] Human 865 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227040 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227040&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963176 336294136 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396777 N[C@H]1C[C@H](C1)NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccc(F)cn2)n(n1)-c1ccccc1 InChI=1S/C26H21Cl2FN6O2/c27-20-11-21(28)19(10-18(20)22-7-6-14(29)13-31-22)25(36)33-24-12-23(26(37)32-16-8-15(30)9-16)34-35(24)17-4-2-1-3-5-17/h1-7,10-13,15-16H,8-9,30H2,(H,32,37)(H,33,36)/t15-,16+ VUJVOKUCLWPOLX-IYBDPMFKSA-N 227041 US9328096, 729 High affinity nerve growth factor receptor [441-796] Human 142 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227041 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227041&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963177 336294137 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396778 C[C@H](N)CNC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccc(F)cn2)n(n1)-c1ccccc1 InChI=1S/C25H21Cl2FN6O2/c1-14(29)12-31-25(36)22-11-23(34(33-22)16-5-3-2-4-6-16)32-24(35)18-9-17(19(26)10-20(18)27)21-8-7-15(28)13-30-21/h2-11,13-14H,12,29H2,1H3,(H,31,36)(H,32,35)/t14-/m0/s1 WZDFRSLVZVQYDS-AWEZNQCLSA-N 227042 US9328096, 730 High affinity nerve growth factor receptor [441-796] Human 429 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227042 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227042&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963178 336294138 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396779 Fc1ccc(nc1)-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)N[C@@H]2CCNC2)c(Cl)cc1Cl InChI=1S/C26H21Cl2FN6O2/c27-20-11-21(28)19(10-18(20)22-7-6-15(29)13-31-22)25(36)33-24-12-23(26(37)32-16-8-9-30-14-16)34-35(24)17-4-2-1-3-5-17/h1-7,10-13,16,30H,8-9,14H2,(H,32,37)(H,33,36)/t16-/m1/s1 TVKZWKGVLUJTGW-MRXNPFEDSA-N 227043 US9328096, 731 High affinity nerve growth factor receptor [441-796] Human 98.7 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227043 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227043&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963179 336294139 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396780 C[C@@H](CN)NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccc(F)cn2)n(n1)-c1ccccc1 InChI=1S/C25H21Cl2FN6O2/c1-14(12-29)31-25(36)22-11-23(34(33-22)16-5-3-2-4-6-16)32-24(35)18-9-17(19(26)10-20(18)27)21-8-7-15(28)13-30-21/h2-11,13-14H,12,29H2,1H3,(H,31,36)(H,32,35)/t14-/m0/s1 GHVVNTGGQUHEIU-AWEZNQCLSA-N 227044 US9328096, 732 High affinity nerve growth factor receptor [441-796] Human 491 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227044 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227044&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963180 336294140 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396781 CN(CCN)C(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccc(F)cn2)n(n1)-c1ccccc1 InChI=1S/C25H21Cl2FN6O2/c1-33(10-9-29)25(36)22-13-23(34(32-22)16-5-3-2-4-6-16)31-24(35)18-11-17(19(26)12-20(18)27)21-8-7-15(28)14-30-21/h2-8,11-14H,9-10,29H2,1H3,(H,31,35) CKJAJULXMVYVTQ-UHFFFAOYSA-N 227045 US9328096, 733 High affinity nerve growth factor receptor [441-796] Human 413 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227045 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227045&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963181 336294141 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396782 NCCCNC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccc(F)cn2)n(n1)-c1ccccc1 InChI=1S/C25H21Cl2FN6O2/c26-19-12-20(27)18(11-17(19)21-8-7-15(28)14-31-21)24(35)32-23-13-22(25(36)30-10-4-9-29)33-34(23)16-5-2-1-3-6-16/h1-3,5-8,11-14H,4,9-10,29H2,(H,30,36)(H,32,35) JJNRSJGKYWYOHC-UHFFFAOYSA-N 227046 US9328096, 734 High affinity nerve growth factor receptor [441-796] Human 73 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227046 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227046&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963182 336294142 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396783 C[C@@H](N)CNC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccc(F)cn2)n(n1)-c1ccccc1 InChI=1S/C25H21Cl2FN6O2/c1-14(29)12-31-25(36)22-11-23(34(33-22)16-5-3-2-4-6-16)32-24(35)18-9-17(19(26)10-20(18)27)21-8-7-15(28)13-30-21/h2-11,13-14H,12,29H2,1H3,(H,31,36)(H,32,35)/t14-/m1/s1 WZDFRSLVZVQYDS-CQSZACIVSA-N 227047 US9328096, 735 High affinity nerve growth factor receptor [441-796] Human 263 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227047 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227047&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963183 336294143 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396784 N[C@@H]1CC[C@H](C1)NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccc(F)cn2)n(n1)-c1ccccc1 InChI=1S/C27H23Cl2FN6O2/c28-21-12-22(29)20(11-19(21)23-9-6-15(30)14-32-23)26(37)34-25-13-24(27(38)33-17-8-7-16(31)10-17)35-36(25)18-4-2-1-3-5-18/h1-6,9,11-14,16-17H,7-8,10,31H2,(H,33,38)(H,34,37)/t16-,17-/m1/s1 GPXJMXXWJOXFNG-IAGOWNOFSA-N 227048 US9328096, 736 High affinity nerve growth factor receptor [441-796] Human 358 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227048 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227048&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963184 336294144 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396785 N[C@H]1C[C@@H](C1)NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccc(F)cn2)n(n1)-c1ccccc1 InChI=1S/C26H21Cl2FN6O2/c27-20-11-21(28)19(10-18(20)22-7-6-14(29)13-31-22)25(36)33-24-12-23(26(37)32-16-8-15(30)9-16)34-35(24)17-4-2-1-3-5-17/h1-7,10-13,15-16H,8-9,30H2,(H,32,37)(H,33,36)/t15-,16- VUJVOKUCLWPOLX-WKILWMFISA-N 227049 US9328096, 737 High affinity nerve growth factor receptor [441-796] Human 116 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227049 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227049&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963177 336294145 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396786 C[C@H](CN)NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccc(F)cn2)n(n1)-c1ccccc1 InChI=1S/C25H21Cl2FN6O2/c1-14(12-29)31-25(36)22-11-23(34(33-22)16-5-3-2-4-6-16)32-24(35)18-9-17(19(26)10-20(18)27)21-8-7-15(28)13-30-21/h2-11,13-14H,12,29H2,1H3,(H,31,36)(H,32,35)/t14-/m1/s1 GHVVNTGGQUHEIU-CQSZACIVSA-N 227050 US9328096, 738 High affinity nerve growth factor receptor [441-796] Human 77.3 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227050 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227050&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963185 336294146 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396787 Fc1ccc(nc1)-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)N[C@H]2CCNC2)c(Cl)cc1Cl InChI=1S/C26H21Cl2FN6O2/c27-20-11-21(28)19(10-18(20)22-7-6-15(29)13-31-22)25(36)33-24-12-23(26(37)32-16-8-9-30-14-16)34-35(24)17-4-2-1-3-5-17/h1-7,10-13,16,30H,8-9,14H2,(H,32,37)(H,33,36)/t16-/m0/s1 TVKZWKGVLUJTGW-INIZCTEOSA-N 227051 US9328096, 739 High affinity nerve growth factor receptor [441-796] Human 261 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227051 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227051&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963186 336294147 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396788 Fc1cccnc1-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)NCc2cncnc2)c(Cl)cc1Cl InChI=1S/C27H18Cl2FN7O2/c28-20-10-21(29)19(9-18(20)25-22(30)7-4-8-33-25)26(38)35-24-11-23(36-37(24)17-5-2-1-3-6-17)27(39)34-14-16-12-31-15-32-13-16/h1-13,15H,14H2,(H,34,39)(H,35,38) XYCBAYLIRXHFPB-UHFFFAOYSA-N 227052 US9328096, 740 High affinity nerve growth factor receptor [441-796] Human 2.02 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227052 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227052&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963187 336294148 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396789 Cn1cnnc1CNC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C26H19Cl2FN8O2/c1-36-14-32-34-23(36)13-31-26(39)21-12-22(37(35-21)15-6-3-2-4-7-15)33-25(38)17-10-16(18(27)11-19(17)28)24-20(29)8-5-9-30-24/h2-12,14H,13H2,1H3,(H,31,39)(H,33,38) LNNSUESZDYFFQK-UHFFFAOYSA-N 227053 US9328096, 741 High affinity nerve growth factor receptor [441-796] Human 36.9 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227053&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963188 336294149 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396790 CC(CO)CNC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C26H22Cl2FN5O3/c1-15(14-35)13-31-26(37)22-12-23(34(33-22)16-6-3-2-4-7-16)32-25(36)18-10-17(19(27)11-20(18)28)24-21(29)8-5-9-30-24/h2-12,15,35H,13-14H2,1H3,(H,31,37)(H,32,36) DPQVGWVJNKBBGC-UHFFFAOYSA-N 227054 US9328096, 742 High affinity nerve growth factor receptor [441-796] Human 4.5 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227054 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227054&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963189 336294150 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396791 OC1(CNC(=O)c2cc(NC(=O)c3cc(c(Cl)cc3Cl)-c3ncccc3F)n(n2)-c2ccccc2)CCC1 InChI=1S/C27H22Cl2FN5O3/c28-19-13-20(29)18(12-17(19)24-21(30)8-4-11-31-24)25(36)33-23-14-22(26(37)32-15-27(38)9-5-10-27)34-35(23)16-6-2-1-3-7-16/h1-4,6-8,11-14,38H,5,9-10,15H2,(H,32,37)(H,33,36) BFQZROJGZSFWMW-UHFFFAOYSA-N 227055 US9328096, 743 High affinity nerve growth factor receptor [441-796] Human 10.4 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227055&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963190 336294151 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396792 CNC(=O)CCNC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C26H21Cl2FN6O3/c1-30-23(36)9-11-32-26(38)21-14-22(35(34-21)15-6-3-2-4-7-15)33-25(37)17-12-16(18(27)13-19(17)28)24-20(29)8-5-10-31-24/h2-8,10,12-14H,9,11H2,1H3,(H,30,36)(H,32,38)(H,33,37) VHQDHRZSVFTWMN-UHFFFAOYSA-N 227056 US9328096, 744 High affinity nerve growth factor receptor [441-796] Human 10.3 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227056 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227056&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963191 336294152 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396793 OCC1(COC1)NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C26H20Cl2FN5O4/c27-18-10-19(28)17(9-16(18)23-20(29)7-4-8-30-23)24(36)31-22-11-21(25(37)32-26(12-35)13-38-14-26)33-34(22)15-5-2-1-3-6-15/h1-11,35H,12-14H2,(H,31,36)(H,32,37) IKHHPLRWZPWNHT-UHFFFAOYSA-N 227057 US9328096, 745 High affinity nerve growth factor receptor [441-796] Human 11.3 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227057 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227057&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963192 336294153 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396794 Fc1cccnc1-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)NCCC#N)c(Cl)cc1Cl InChI=1S/C25H17Cl2FN6O2/c26-18-13-19(27)17(12-16(18)23-20(28)8-4-10-30-23)24(35)32-22-14-21(25(36)31-11-5-9-29)33-34(22)15-6-2-1-3-7-15/h1-4,6-8,10,12-14H,5,11H2,(H,31,36)(H,32,35) RWZRGLYDSCFRQU-UHFFFAOYSA-N 227058 US9328096, 746 High affinity nerve growth factor receptor [441-796] Human 3.25 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227058 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227058&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963193 336294154 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396795 CNC(=O)C(NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1)C#N InChI=1S/C26H18Cl2FN7O3/c1-31-25(38)21(13-30)33-26(39)20-12-22(36(35-20)14-6-3-2-4-7-14)34-24(37)16-10-15(17(27)11-18(16)28)23-19(29)8-5-9-32-23/h2-12,21H,1H3,(H,31,38)(H,33,39)(H,34,37) SBJRXYBJEXRWEY-UHFFFAOYSA-N 227059 US9328096, 747 High affinity nerve growth factor receptor [441-796] Human 9.13 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227059 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227059&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963194 336294155 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396796 Fc1cccnc1-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)NCCc2ncn[nH]2)c(Cl)cc1Cl InChI=1S/C26H19Cl2FN8O2/c27-18-12-19(28)17(11-16(18)24-20(29)7-4-9-30-24)25(38)34-23-13-21(36-37(23)15-5-2-1-3-6-15)26(39)31-10-8-22-32-14-33-35-22/h1-7,9,11-14H,8,10H2,(H,31,39)(H,34,38)(H,32,33,35) KYQBZFQXPKQJRD-UHFFFAOYSA-N 227060 US9328096, 748 High affinity nerve growth factor receptor [441-796] Human 14.9 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227060 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227060&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963195 336294156 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396797 CC(=O)NCCNC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C26H21Cl2FN6O3/c1-15(36)30-10-11-32-26(38)22-14-23(35(34-22)16-6-3-2-4-7-16)33-25(37)18-12-17(19(27)13-20(18)28)24-21(29)8-5-9-31-24/h2-9,12-14H,10-11H2,1H3,(H,30,36)(H,32,38)(H,33,37) MNNAXWISLMXNTP-UHFFFAOYSA-N 227061 US9328096, 749 High affinity nerve growth factor receptor [441-796] Human 15.4 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227061 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227061&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963196 336294157 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396798 Cn1nncc1CNC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C26H19Cl2FN8O2/c1-36-16(14-32-35-36)13-31-26(39)22-12-23(37(34-22)15-6-3-2-4-7-15)33-25(38)18-10-17(19(27)11-20(18)28)24-21(29)8-5-9-30-24/h2-12,14H,13H2,1H3,(H,31,39)(H,33,38) MHMDEQBBSWBPDX-UHFFFAOYSA-N 227062 US9328096, 750 High affinity nerve growth factor receptor [441-796] Human 5.96 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227062 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227062&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963197 336294158 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396799 CNC1CN(C1)C(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C26H21Cl2FN6O2/c1-30-15-13-34(14-15)26(37)22-12-23(35(33-22)16-6-3-2-4-7-16)32-25(36)18-10-17(19(27)11-20(18)28)24-21(29)8-5-9-31-24/h2-12,15,30H,13-14H2,1H3,(H,32,36) PPCGKHPZTZQISS-UHFFFAOYSA-N 227063 US9328096, 751 High affinity nerve growth factor receptor [441-796] Human 16.8 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227063 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227063&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963198 336294159 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396800 Fc1cccnc1-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)NCCN2CCNCC2=O)c(Cl)cc1Cl InChI=1S/C28H24Cl2FN7O3/c29-20-14-21(30)19(13-18(20)26-22(31)7-4-8-33-26)27(40)35-24-15-23(36-38(24)17-5-2-1-3-6-17)28(41)34-10-12-37-11-9-32-16-25(37)39/h1-8,13-15,32H,9-12,16H2,(H,34,41)(H,35,40) BLNXWVPVCOUIGU-UHFFFAOYSA-N 227064 US9328096, 752 High affinity nerve growth factor receptor [441-796] Human 126 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227064 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227064&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963199 336294160 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396801 C[C@@H](CNC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1)NC(=O)CN InChI=1S/C27H24Cl2FN7O3/c1-15(34-24(38)13-31)14-33-27(40)22-12-23(37(36-22)16-6-3-2-4-7-16)35-26(39)18-10-17(19(28)11-20(18)29)25-21(30)8-5-9-32-25/h2-12,15H,13-14,31H2,1H3,(H,33,40)(H,34,38)(H,35,39)/t15-/m0/s1 PCLDNWLIJLRGQG-HNNXBMFYSA-N 227065 US9328096, 753 High affinity nerve growth factor receptor [441-796] Human 471 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227065 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227065&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963200 336294161 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396802 CNC1(C)CN(C1)C(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C27H23Cl2FN6O2/c1-27(31-2)14-35(15-27)26(38)22-13-23(36(34-22)16-7-4-3-5-8-16)33-25(37)18-11-17(19(28)12-20(18)29)24-21(30)9-6-10-32-24/h3-13,31H,14-15H2,1-2H3,(H,33,37) DZMZVZWTQKHKBW-UHFFFAOYSA-N 227066 US9328096, 754 High affinity nerve growth factor receptor [441-796] Human 22.7 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227066 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227066&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963201 336294162 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396803 CC1(N)CCN(CC1)C(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C28H25Cl2FN6O2/c1-28(32)9-12-36(13-10-28)27(39)23-16-24(37(35-23)17-6-3-2-4-7-17)34-26(38)19-14-18(20(29)15-21(19)30)25-22(31)8-5-11-33-25/h2-8,11,14-16H,9-10,12-13,32H2,1H3,(H,34,38) XHFLDUSSIWVTAM-UHFFFAOYSA-N 227067 US9328096, 755 High affinity nerve growth factor receptor [441-796] Human 91.8 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227067 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227067&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963202 336294163 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396804 NCCC1CN(CCO1)C(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C28H25Cl2FN6O3/c29-21-14-22(30)20(13-19(21)26-23(31)7-4-10-33-26)27(38)34-25-15-24(35-37(25)17-5-2-1-3-6-17)28(39)36-11-12-40-18(16-36)8-9-32/h1-7,10,13-15,18H,8-9,11-12,16,32H2,(H,34,38) SUEDSNQCRKFRNT-UHFFFAOYSA-N 227068 US9328096, 756 High affinity nerve growth factor receptor [441-796] Human 214 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227068 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227068&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963203 336294164 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396805 Fc1cccnc1-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)N2CC3CNC3C2)c(Cl)cc1Cl InChI=1S/C27H21Cl2FN6O2/c28-19-10-20(29)18(9-17(19)25-21(30)7-4-8-31-25)26(37)33-24-11-22(34-36(24)16-5-2-1-3-6-16)27(38)35-13-15-12-32-23(15)14-35/h1-11,15,23,32H,12-14H2,(H,33,37) BYJQRRKBQSDCMO-UHFFFAOYSA-N 227069 US9328096, 757 High affinity nerve growth factor receptor [441-796] Human 116 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227069 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227069&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963204 336294165 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396806 NC1CC2(C1)CCN(CC2)C(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C30H27Cl2FN6O2/c31-22-14-23(32)21(13-20(22)27-24(33)7-4-10-35-27)28(40)36-26-15-25(37-39(26)19-5-2-1-3-6-19)29(41)38-11-8-30(9-12-38)16-18(34)17-30/h1-7,10,13-15,18H,8-9,11-12,16-17,34H2,(H,36,40) KLBRQASELWTTSX-UHFFFAOYSA-N 227070 US9328096, 758 High affinity nerve growth factor receptor [441-796] Human 55.2 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227070 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227070&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963205 336294166 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396807 N[C@H]1CCN(C1)C(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C26H21Cl2FN6O2/c27-19-12-20(28)18(11-17(19)24-21(29)7-4-9-31-24)25(36)32-23-13-22(26(37)34-10-8-15(30)14-34)33-35(23)16-5-2-1-3-6-16/h1-7,9,11-13,15H,8,10,14,30H2,(H,32,36)/t15-/m0/s1 VTVUNTCUMHVWDW-HNNXBMFYSA-N 227071 US9328096, 759 High affinity nerve growth factor receptor [441-796] Human 20.7 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227071 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227071&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963206 336294167 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396808 OC1[C@@H]2CN([C@H]1CN2)C(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C27H21Cl2FN6O3/c28-17-10-18(29)16(9-15(17)24-19(30)7-4-8-31-24)26(38)33-23-11-20(34-36(23)14-5-2-1-3-6-14)27(39)35-13-21-25(37)22(35)12-32-21/h1-11,21-22,25,32,37H,12-13H2,(H,33,38)/t21-,22-,25?/m0/s1 ULCROAKXTXLPAM-NTETXRHWSA-N 227072 US9328096, 760 High affinity nerve growth factor receptor [441-796] Human 352 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227072 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227072&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963207 336294168 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396809 CC1(N)CCN(C1)C(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C27H23Cl2FN6O2/c1-27(31)9-11-35(15-27)26(38)22-14-23(36(34-22)16-6-3-2-4-7-16)33-25(37)18-12-17(19(28)13-20(18)29)24-21(30)8-5-10-32-24/h2-8,10,12-14H,9,11,15,31H2,1H3,(H,33,37) PMFAFDCJPZSFPJ-UHFFFAOYSA-N 227073 US9328096, 761 High affinity nerve growth factor receptor [441-796] Human 38.5 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227073 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227073&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963208 336294169 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396810 CNC1CCN(CC1)C(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C28H25Cl2FN6O2/c1-32-17-9-12-36(13-10-17)28(39)24-16-25(37(35-24)18-6-3-2-4-7-18)34-27(38)20-14-19(21(29)15-22(20)30)26-23(31)8-5-11-33-26/h2-8,11,14-17,32H,9-10,12-13H2,1H3,(H,34,38) BZNYQHMPWSAMTK-UHFFFAOYSA-N 227074 US9328096, 762 High affinity nerve growth factor receptor [441-796] Human 140 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227074 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227074&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963209 336294170 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396811 NC12CC1CN(C2)C(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C27H21Cl2FN6O2/c28-19-10-20(29)18(9-17(19)24-21(30)7-4-8-32-24)25(37)33-23-11-22(34-36(23)16-5-2-1-3-6-16)26(38)35-13-15-12-27(15,31)14-35/h1-11,15H,12-14,31H2,(H,33,37) BJHVQPJAJGSHGF-UHFFFAOYSA-N 227075 US9328096, 763 High affinity nerve growth factor receptor [441-796] Human 20.1 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227075 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227075&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963210 336294171 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396812 NC1CCN(C1)C(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C26H21Cl2FN6O2/c27-19-12-20(28)18(11-17(19)24-21(29)7-4-9-31-24)25(36)32-23-13-22(26(37)34-10-8-15(30)14-34)33-35(23)16-5-2-1-3-6-16/h1-7,9,11-13,15H,8,10,14,30H2,(H,32,36) VTVUNTCUMHVWDW-UHFFFAOYSA-N 227076 US9328096, 764 High affinity nerve growth factor receptor [441-796] Human 32.1 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227076 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227076&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963211 336294172 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396813 NCCN1CCN(CC1)C(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C28H26Cl2FN7O2/c29-21-16-22(30)20(15-19(21)26-23(31)7-4-9-33-26)27(39)34-25-17-24(35-38(25)18-5-2-1-3-6-18)28(40)37-13-11-36(10-8-32)12-14-37/h1-7,9,15-17H,8,10-14,32H2,(H,34,39) DFIDTMBBTQFSBE-UHFFFAOYSA-N 227077 US9328096, 765 High affinity nerve growth factor receptor [441-796] Human 211 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227077 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227077&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963212 336294173 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396814 NC1CCN(CC1)C(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C27H23Cl2FN6O2/c28-20-14-21(29)19(13-18(20)25-22(30)7-4-10-32-25)26(37)33-24-15-23(27(38)35-11-8-16(31)9-12-35)34-36(24)17-5-2-1-3-6-17/h1-7,10,13-16H,8-9,11-12,31H2,(H,33,37) MLDRSCZQALCLLB-UHFFFAOYSA-N 227078 US9328096, 766 High affinity nerve growth factor receptor [441-796] Human 105 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227078 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227078&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963213 336294174 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396815 CC1(N)CN(C1)C(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C26H21Cl2FN6O2/c1-26(30)13-34(14-26)25(37)21-12-22(35(33-21)15-6-3-2-4-7-15)32-24(36)17-10-16(18(27)11-19(17)28)23-20(29)8-5-9-31-23/h2-12H,13-14,30H2,1H3,(H,32,36) NSEGRQJEFAANHS-UHFFFAOYSA-N 227079 US9328096, 767 High affinity nerve growth factor receptor [441-796] Human 17 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227079 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227079&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963214 336294175 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396816 Fc1cccnc1-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)N2C[C@@H]3C[C@H]2CN3)c(Cl)cc1Cl InChI=1S/C27H21Cl2FN6O2/c28-20-11-21(29)19(10-18(20)25-22(30)7-4-8-31-25)26(37)33-24-12-23(34-36(24)16-5-2-1-3-6-16)27(38)35-14-15-9-17(35)13-32-15/h1-8,10-12,15,17,32H,9,13-14H2,(H,33,37)/t15-,17-/m0/s1 NHZSBJYDXCXBFA-RDJZCZTQSA-N 227080 US9328096, 768 High affinity nerve growth factor receptor [441-796] Human 35 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227080 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227080&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963215 336294176 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396817 CNC1CCN(C1)C(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C27H23Cl2FN6O2/c1-31-16-9-11-35(15-16)27(38)23-14-24(36(34-23)17-6-3-2-4-7-17)33-26(37)19-12-18(20(28)13-21(19)29)25-22(30)8-5-10-32-25/h2-8,10,12-14,16,31H,9,11,15H2,1H3,(H,33,37) FIHKTTCZCROYBJ-UHFFFAOYSA-N 227081 US9328096, 769 High affinity nerve growth factor receptor [441-796] Human 34 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227081 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227081&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963216 336294177 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396818 NC1[C@@H]2CN(C[C@H]12)C(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C27H21Cl2FN6O2/c28-19-10-20(29)16(9-15(19)25-21(30)7-4-8-32-25)26(37)33-23-11-22(34-36(23)14-5-2-1-3-6-14)27(38)35-12-17-18(13-35)24(17)31/h1-11,17-18,24H,12-13,31H2,(H,33,37)/t17-,18+,24? MYIPMZPZFIYTIU-QLCVBSLISA-N 227082 US9328096, 770 High affinity nerve growth factor receptor [441-796] Human 22.3 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227082 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227082&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963217 336294178 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396819 N[C@@H]1CCN(C1)C(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C26H21Cl2FN6O2/c27-19-12-20(28)18(11-17(19)24-21(29)7-4-9-31-24)25(36)32-23-13-22(26(37)34-10-8-15(30)14-34)33-35(23)16-5-2-1-3-6-16/h1-7,9,11-13,15H,8,10,14,30H2,(H,32,36)/t15-/m1/s1 VTVUNTCUMHVWDW-OAHLLOKOSA-N 227083 US9328096, 771 High affinity nerve growth factor receptor [441-796] Human 35.7 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227083 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227083&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963218 336294179 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396820 N[C@H]1CN(C[C@@H]1F)C(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C26H20Cl2F2N6O2/c27-17-10-18(28)16(9-15(17)24-19(29)7-4-8-32-24)25(37)33-23-11-22(26(38)35-12-20(30)21(31)13-35)34-36(23)14-5-2-1-3-6-14/h1-11,20-21H,12-13,31H2,(H,33,37)/t20-,21-/m0/s1 BGGJHXDVCWQLQR-SFTDATJTSA-N 227084 US9328096, 772 High affinity nerve growth factor receptor [441-796] Human 10.8 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227084 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227084&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 121297533 336294180 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396821 Fc1cc(Cl)c(cc1-c1ncccc1F)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NC1CCNCC1(F)F InChI=1S/C27H21ClF4N6O2/c28-18-12-20(30)17(24-19(29)7-4-9-34-24)11-16(18)25(39)36-23-13-21(37-38(23)15-5-2-1-3-6-15)26(40)35-22-8-10-33-14-27(22,31)32/h1-7,9,11-13,22,33H,8,10,14H2,(H,35,40)(H,36,39) DVVLWQNOINDRDI-UHFFFAOYSA-N 227085 US9328096, 773 High affinity nerve growth factor receptor [441-796] Human 7.66 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227085 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227085&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963219 336294181 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396822 Fc1cccnc1-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)NCC2(F)CCCNC2)c(Cl)cc1F InChI=1S/C28H24ClF3N6O2/c29-20-13-22(31)19(25-21(30)8-4-11-34-25)12-18(20)26(39)36-24-14-23(37-38(24)17-6-2-1-3-7-17)27(40)35-16-28(32)9-5-10-33-15-28/h1-4,6-8,11-14,33H,5,9-10,15-16H2,(H,35,40)(H,36,39) YHMOIXASLQBPOA-UHFFFAOYSA-N 227086 US9328096, 774 High affinity nerve growth factor receptor [441-796] Human 45.1 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227086 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227086&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963220 336294182 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396823 Fc1cc(Cl)c(cc1-c1ncccc1F)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCC1(F)CNC1 InChI=1S/C26H20ClF3N6O2/c27-18-10-20(29)17(23-19(28)7-4-8-32-23)9-16(18)24(37)34-22-11-21(25(38)33-14-26(30)12-31-13-26)35-36(22)15-5-2-1-3-6-15/h1-11,31H,12-14H2,(H,33,38)(H,34,37) URSLXQOSWGMKNO-UHFFFAOYSA-N 227087 US9328096, 775 High affinity nerve growth factor receptor [441-796] Human 58.3 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227087 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227087&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963221 336294183 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396824 F[C@@H]1CNCC[C@H]1NC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C27H22ClF3N6O2/c28-18-12-20(30)17(25-19(29)7-4-9-33-25)11-16(18)26(38)35-24-13-23(36-37(24)15-5-2-1-3-6-15)27(39)34-22-8-10-32-14-21(22)31/h1-7,9,11-13,21-22,32H,8,10,14H2,(H,34,39)(H,35,38)/t21-,22-/m1/s1 GUWKIZWXKYPMEJ-FGZHOGPDSA-N 227088 US9328096, 776 High affinity nerve growth factor receptor [441-796] Human 18.9 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227088&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963222 336294184 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396825 Fc1cccnc1-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)NCC2CNCCC2(F)F)c(Cl)cc1F InChI=1S/C28H23ClF4N6O2/c29-20-12-22(31)19(25-21(30)7-4-9-35-25)11-18(20)26(40)37-24-13-23(38-39(24)17-5-2-1-3-6-17)27(41)36-15-16-14-34-10-8-28(16,32)33/h1-7,9,11-13,16,34H,8,10,14-15H2,(H,36,41)(H,37,40) BIGPPXCUQXRBSC-UHFFFAOYSA-N 227089 US9328096, 777 High affinity nerve growth factor receptor [441-796] Human 57.4 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227089 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227089&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963223 336294185 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396826 NC1CCN(CC1(F)F)C(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C27H21ClF4N6O2/c28-18-12-20(30)17(24-19(29)7-4-9-34-24)11-16(18)25(39)35-23-13-21(36-38(23)15-5-2-1-3-6-15)26(40)37-10-8-22(33)27(31,32)14-37/h1-7,9,11-13,22H,8,10,14,33H2,(H,35,39) RBCLJCPGOKDZEF-UHFFFAOYSA-N 227090 US9328096, 778 High affinity nerve growth factor receptor [441-796] Human 66 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227090 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227090&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963224 336294186 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396827 FC1CCNCC1CNC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C28H24ClF3N6O2/c29-20-12-23(32)19(26-22(31)7-4-9-34-26)11-18(20)27(39)36-25-13-24(37-38(25)17-5-2-1-3-6-17)28(40)35-15-16-14-33-10-8-21(16)30/h1-7,9,11-13,16,21,33H,8,10,14-15H2,(H,35,40)(H,36,39) SVWTXMCYFGNRAY-UHFFFAOYSA-N 227091 US9328096, 779 High affinity nerve growth factor receptor [441-796] Human 49.1 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227091 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227091&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963225 336294187 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396828 F[C@H]1CNC[C@@H]1NC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C26H20ClF3N6O2/c27-17-10-19(29)16(24-18(28)7-4-8-32-24)9-15(17)25(37)34-23-11-21(26(38)33-22-13-31-12-20(22)30)35-36(23)14-5-2-1-3-6-14/h1-11,20,22,31H,12-13H2,(H,33,38)(H,34,37)/t20-,22-/m0/s1 VKRFHNFISUGOSB-UNMCSNQZSA-N 227092 US9328096, 780 High affinity nerve growth factor receptor [441-796] Human 49.9 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227092 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227092&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963226 336294188 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396829 Fc1cccnc1-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)NCC2(F)CCNC2)c(Cl)cc1F InChI=1S/C27H22ClF3N6O2/c28-19-12-21(30)18(24-20(29)7-4-9-33-24)11-17(19)25(38)35-23-13-22(36-37(23)16-5-2-1-3-6-16)26(39)34-15-27(31)8-10-32-14-27/h1-7,9,11-13,32H,8,10,14-15H2,(H,34,39)(H,35,38) GHAZOEHRAYCADB-UHFFFAOYSA-N 227093 US9328096, 781 High affinity nerve growth factor receptor [441-796] Human 40.6 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227093 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227093&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963227 336294189 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396830 Fc1cccnc1-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)NC2CNCC2(F)F)c(Cl)cc1F InChI=1S/C26H19ClF4N6O2/c27-17-10-19(29)16(23-18(28)7-4-8-33-23)9-15(17)24(38)35-22-11-20(36-37(22)14-5-2-1-3-6-14)25(39)34-21-12-32-13-26(21,30)31/h1-11,21,32H,12-13H2,(H,34,39)(H,35,38) JTQJIMSPVOONKS-UHFFFAOYSA-N 227094 US9328096, 782 High affinity nerve growth factor receptor [441-796] Human 30.8 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227094 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227094&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963228 336294190 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396831 Fc1cc(Cl)c(cc1-c1ncccc1F)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NC1CNCC(F)(F)C1 InChI=1S/C27H21ClF4N6O2/c28-19-10-21(30)18(24-20(29)7-4-8-34-24)9-17(19)25(39)36-23-11-22(37-38(23)16-5-2-1-3-6-16)26(40)35-15-12-27(31,32)14-33-13-15/h1-11,15,33H,12-14H2,(H,35,40)(H,36,39) IHLDAJNMYMDJOC-UHFFFAOYSA-N 227095 US9328096, 783 High affinity nerve growth factor receptor [441-796] Human 24.8 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227095 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227095&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963229 336294191 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396832 F[C@H]1CNC[C@H]1NC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C26H20ClF3N6O2/c27-17-10-19(29)16(24-18(28)7-4-8-32-24)9-15(17)25(37)34-23-11-21(26(38)33-22-13-31-12-20(22)30)35-36(23)14-5-2-1-3-6-14/h1-11,20,22,31H,12-13H2,(H,33,38)(H,34,37)/t20-,22+/m0/s1 VKRFHNFISUGOSB-RBBKRZOGSA-N 227096 US9328096, 784 High affinity nerve growth factor receptor [441-796] Human 29.7 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227096 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227096&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963230 336294192 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396833 F[C@@H]1CNCC[C@@H]1NC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C27H22ClF3N6O2/c28-18-12-20(30)17(25-19(29)7-4-9-33-25)11-16(18)26(38)35-24-13-23(36-37(24)15-5-2-1-3-6-15)27(39)34-22-8-10-32-14-21(22)31/h1-7,9,11-13,21-22,32H,8,10,14H2,(H,34,39)(H,35,38)/t21-,22+/m1/s1 GUWKIZWXKYPMEJ-YADHBBJMSA-N 227097 US9328096, 785 High affinity nerve growth factor receptor [441-796] Human 19.4 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227097 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227097&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963231 336294193 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396834 Fc1cc(Cl)c(cc1-c1ncccc1F)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NC[C@@H]1CC(F)(F)CN1 InChI=1S/C27H21ClF4N6O2/c28-19-10-21(30)18(24-20(29)7-4-8-33-24)9-17(19)25(39)36-23-11-22(37-38(23)16-5-2-1-3-6-16)26(40)34-13-15-12-27(31,32)14-35-15/h1-11,15,35H,12-14H2,(H,34,40)(H,36,39)/t15-/m0/s1 IYFNMDUQSGCBND-HNNXBMFYSA-N 227098 US9328096, 786 High affinity nerve growth factor receptor [441-796] Human 36.5 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227098 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227098&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963232 336294194 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396835 FC1CNCC1NC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C26H20ClF3N6O2/c27-17-10-19(29)16(24-18(28)7-4-8-32-24)9-15(17)25(37)34-23-11-21(26(38)33-22-13-31-12-20(22)30)35-36(23)14-5-2-1-3-6-14/h1-11,20,22,31H,12-13H2,(H,33,38)(H,34,37) VKRFHNFISUGOSB-UHFFFAOYSA-N 227099 US9328096, 787 High affinity nerve growth factor receptor [441-796] Human 28.9 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227099 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227099&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963233 336294195 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396836 N[C@H]1CN(CC[C@H]1F)C(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C27H22ClF3N6O2/c28-18-12-21(31)17(25-20(30)7-4-9-33-25)11-16(18)26(38)34-24-13-23(35-37(24)15-5-2-1-3-6-15)27(39)36-10-8-19(29)22(32)14-36/h1-7,9,11-13,19,22H,8,10,14,32H2,(H,34,38)/t19-,22+/m1/s1 CMHMMDGYNJECDV-KNQAVFIVSA-N 227100 US9328096, 788 High affinity nerve growth factor receptor [441-796] Human 82.2 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227100 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227100&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963234 336294196 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396837 Fc1cc(Cl)c(cc1-c1ncccc1F)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NC[C@H]1CC(F)(F)CN1 InChI=1S/C27H21ClF4N6O2/c28-19-10-21(30)18(24-20(29)7-4-8-33-24)9-17(19)25(39)36-23-11-22(37-38(23)16-5-2-1-3-6-16)26(40)34-13-15-12-27(31,32)14-35-15/h1-11,15,35H,12-14H2,(H,34,40)(H,36,39)/t15-/m1/s1 IYFNMDUQSGCBND-OAHLLOKOSA-N 227101 US9328096, 789 High affinity nerve growth factor receptor [441-796] Human 171 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227101 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227101&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963235 336294197 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396838 FC[C@@H]1CN(CCN1)C(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C27H22ClF3N6O2/c28-20-12-22(31)19(25-21(30)7-4-8-33-25)11-18(20)26(38)34-24-13-23(35-37(24)17-5-2-1-3-6-17)27(39)36-10-9-32-16(14-29)15-36/h1-8,11-13,16,32H,9-10,14-15H2,(H,34,38)/t16-/m1/s1 YBGWQCBMJGDMDS-MRXNPFEDSA-N 227102 US9328096, 790 High affinity nerve growth factor receptor [441-796] Human 87.6 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227102 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227102&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963236 336294198 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396839 N[C@@H]1CN(CC[C@H]1F)C(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C27H22ClF3N6O2/c28-18-12-21(31)17(25-20(30)7-4-9-33-25)11-16(18)26(38)34-24-13-23(35-37(24)15-5-2-1-3-6-15)27(39)36-10-8-19(29)22(32)14-36/h1-7,9,11-13,19,22H,8,10,14,32H2,(H,34,38)/t19-,22-/m1/s1 CMHMMDGYNJECDV-DENIHFKCSA-N 227103 US9328096, 791 High affinity nerve growth factor receptor [441-796] Human 54.7 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227103 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227103&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963237 336294199 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396840 NC1CN(CCC1F)C(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C27H22ClF3N6O2/c28-18-12-21(31)17(25-20(30)7-4-9-33-25)11-16(18)26(38)34-24-13-23(35-37(24)15-5-2-1-3-6-15)27(39)36-10-8-19(29)22(32)14-36/h1-7,9,11-13,19,22H,8,10,14,32H2,(H,34,38) CMHMMDGYNJECDV-UHFFFAOYSA-N 227104 US9328096, 792 High affinity nerve growth factor receptor [441-796] Human 36.9 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227104 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227104&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963238 336294200 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396841 F[C@@H]1CN[C@H](CNC(=O)c2cc(NC(=O)c3cc(c(F)cc3Cl)-c3ncccc3F)n(n2)-c2ccccc2)C1 InChI=1S/C27H22ClF3N6O2/c28-20-11-22(31)19(25-21(30)7-4-8-32-25)10-18(20)26(38)35-24-12-23(36-37(24)17-5-2-1-3-6-17)27(39)34-14-16-9-15(29)13-33-16/h1-8,10-12,15-16,33H,9,13-14H2,(H,34,39)(H,35,38)/t15-,16-/m0/s1 GVBODXPGXLHOMO-HOTGVXAUSA-N 227105 US9328096, 793 High affinity nerve growth factor receptor [441-796] Human 61.9 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227105 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227105&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963239 336294201 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396842 FC1CNCCC1NC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C27H22ClF3N6O2/c28-18-12-20(30)17(25-19(29)7-4-9-33-25)11-16(18)26(38)35-24-13-23(36-37(24)15-5-2-1-3-6-15)27(39)34-22-8-10-32-14-21(22)31/h1-7,9,11-13,21-22,32H,8,10,14H2,(H,34,39)(H,35,38) GUWKIZWXKYPMEJ-UHFFFAOYSA-N 227106 US9328096, 794 High affinity nerve growth factor receptor [441-796] Human 25.7 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227106 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227106&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963240 336294202 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396843 NCC(F)(F)CNC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C25H19ClF4N6O2/c26-17-10-19(28)16(22-18(27)7-4-8-32-22)9-15(17)23(37)34-21-11-20(24(38)33-13-25(29,30)12-31)35-36(21)14-5-2-1-3-6-14/h1-11H,12-13,31H2,(H,33,38)(H,34,37) PNEIXLQQCYSQIW-UHFFFAOYSA-N 227107 US9328096, 795 High affinity nerve growth factor receptor [441-796] Human 14.6 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227107 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227107&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 121297536 336294203 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396844 CN1CCCC(CNC(=O)c2cc(NC(=O)c3cc(ccc3Cl)-c3ncccc3F)n(n2)-c2ccccc2)C1 InChI=1S/C29H28ClFN6O2/c1-36-14-6-7-19(18-36)17-33-29(39)25-16-26(37(35-25)21-8-3-2-4-9-21)34-28(38)22-15-20(11-12-23(22)30)27-24(31)10-5-13-32-27/h2-5,8-13,15-16,19H,6-7,14,17-18H2,1H3,(H,33,39)(H,34,38) ZDMZVMJGPIACOX-UHFFFAOYSA-N 227108 US9328096, 796 High affinity nerve growth factor receptor [441-796] Human 334 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227108 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227108&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963241 336294204 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396845 CN1CC(C1)NC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C26H22ClFN6O2/c1-33-14-17(15-33)30-26(36)22-13-23(34(32-22)18-6-3-2-4-7-18)31-25(35)19-12-16(9-10-20(19)27)24-21(28)8-5-11-29-24/h2-13,17H,14-15H2,1H3,(H,30,36)(H,31,35) BZKBHHOUDRVPEB-UHFFFAOYSA-N 227109 US9328096, 797 High affinity nerve growth factor receptor [441-796] Human 144 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227109 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227109&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963242 336294205 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396846 COCC(CN(C)C)NC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C28H28ClFN6O3/c1-35(2)16-19(17-39-3)32-28(38)24-15-25(36(34-24)20-8-5-4-6-9-20)33-27(37)21-14-18(11-12-22(21)29)26-23(30)10-7-13-31-26/h4-15,19H,16-17H2,1-3H3,(H,32,38)(H,33,37) CNTPRAYPFGYQKE-UHFFFAOYSA-N 227110 US9328096, 798 High affinity nerve growth factor receptor [441-796] Human 868 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227110 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227110&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963243 336294206 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396847 CN1CC[C@H](C1)NC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C27H24ClFN6O2/c1-34-13-11-18(16-34)31-27(37)23-15-24(35(33-23)19-6-3-2-4-7-19)32-26(36)20-14-17(9-10-21(20)28)25-22(29)8-5-12-30-25/h2-10,12,14-15,18H,11,13,16H2,1H3,(H,31,37)(H,32,36)/t18-/m1/s1 SERCRJMPUISXEW-GOSISDBHSA-N 227111 US9328096, 799 High affinity nerve growth factor receptor [441-796] Human 132 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227111 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227111&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963244 336294207 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396848 CN1C2CCC1CC(C2)NC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C30H28ClFN6O2/c1-37-21-10-11-22(37)16-19(15-21)34-30(40)26-17-27(38(36-26)20-6-3-2-4-7-20)35-29(39)23-14-18(9-12-24(23)31)28-25(32)8-5-13-33-28/h2-9,12-14,17,19,21-22H,10-11,15-16H2,1H3,(H,34,40)(H,35,39) WEONPIZQHIHBNJ-UHFFFAOYSA-N 227112 US9328096, 800 High affinity nerve growth factor receptor [441-796] Human 221 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227112 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227112&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963245 336294208 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396849 CN1CCC(C)(CNC(=O)c2cc(NC(=O)c3cc(ccc3Cl)-c3ncccc3F)n(n2)-c2ccccc2)C1 InChI=1S/C29H28ClFN6O2/c1-29(12-14-36(2)18-29)17-33-28(39)24-16-25(37(35-24)20-7-4-3-5-8-20)34-27(38)21-15-19(10-11-22(21)30)26-23(31)9-6-13-32-26/h3-11,13,15-16H,12,14,17-18H2,1-2H3,(H,33,39)(H,34,38) PGHHDQOCCOFYHL-UHFFFAOYSA-N 227113 US9328096, 801 High affinity nerve growth factor receptor [441-796] Human 239 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227113 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227113&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963246 336294209 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396850 CN(C)CCC(O)CNC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C28H28ClFN6O3/c1-35(2)14-12-20(37)17-32-28(39)24-16-25(36(34-24)19-7-4-3-5-8-19)33-27(38)21-15-18(10-11-22(21)29)26-23(30)9-6-13-31-26/h3-11,13,15-16,20,37H,12,14,17H2,1-2H3,(H,32,39)(H,33,38) LHFILMURSIFVIH-UHFFFAOYSA-N 227114 US9328096, 802 High affinity nerve growth factor receptor [441-796] Human 299 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227114 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227114&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963247 336294210 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396851 Fc1cccnc1-c1ccc(Cl)c(c1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NC1CN2CCC1C2 InChI=1S/C28H24ClFN6O2/c29-21-9-8-17(26-22(30)7-4-11-31-26)13-20(21)27(37)33-25-14-23(34-36(25)19-5-2-1-3-6-19)28(38)32-24-16-35-12-10-18(24)15-35/h1-9,11,13-14,18,24H,10,12,15-16H2,(H,32,38)(H,33,37) MAVBNADNFASPAI-UHFFFAOYSA-N 227115 US9328096, 803 High affinity nerve growth factor receptor [441-796] Human 124 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227115 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227115&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963248 336294211 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396852 CN1CCC(CNC(=O)c2cc(NC(=O)c3cc(ccc3Cl)-c3ncccc3F)n(n2)-c2ccccc2)C1 InChI=1S/C28H26ClFN6O2/c1-35-13-11-18(17-35)16-32-28(38)24-15-25(36(34-24)20-6-3-2-4-7-20)33-27(37)21-14-19(9-10-22(21)29)26-23(30)8-5-12-31-26/h2-10,12,14-15,18H,11,13,16-17H2,1H3,(H,32,38)(H,33,37) GNCJPFKTOPHTFZ-UHFFFAOYSA-N 227116 US9328096, 804 High affinity nerve growth factor receptor [441-796] Human 483 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227116 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227116&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963249 336294212 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396853 Fc1cccnc1-c1ccc(Cl)c(c1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NC1CN2CCC1CC2 InChI=1S/C29H26ClFN6O2/c30-22-9-8-19(27-23(31)7-4-12-32-27)15-21(22)28(38)34-26-16-24(35-37(26)20-5-2-1-3-6-20)29(39)33-25-17-36-13-10-18(25)11-14-36/h1-9,12,15-16,18,25H,10-11,13-14,17H2,(H,33,39)(H,34,38) FRMLIGLXWYZFOZ-UHFFFAOYSA-N 227117 US9328096, 805 High affinity nerve growth factor receptor [441-796] Human 101 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227117 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227117&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963250 336294213 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396854 CN1CC(CNC(=O)c2cc(NC(=O)c3cc(ccc3Cl)-c3ncccc3F)n(n2)-c2ccccc2)C1 InChI=1S/C27H24ClFN6O2/c1-34-15-17(16-34)14-31-27(37)23-13-24(35(33-23)19-6-3-2-4-7-19)32-26(36)20-12-18(9-10-21(20)28)25-22(29)8-5-11-30-25/h2-13,17H,14-16H2,1H3,(H,31,37)(H,32,36) WZMYIQQJOIHMBR-UHFFFAOYSA-N 227118 US9328096, 806 High affinity nerve growth factor receptor [441-796] Human 492 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227118&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963251 336294214 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396855 Fc1cccnc1-c1ccc(Cl)c(c1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCCN1CCOCC1 InChI=1S/C28H26ClFN6O3/c29-22-9-8-19(26-23(30)7-4-10-31-26)17-21(22)27(37)33-25-18-24(34-36(25)20-5-2-1-3-6-20)28(38)32-11-12-35-13-15-39-16-14-35/h1-10,17-18H,11-16H2,(H,32,38)(H,33,37) LHSLNBXKNYNRJY-UHFFFAOYSA-N 227119 US9328096, 807 High affinity nerve growth factor receptor [441-796] Human 201 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227119 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227119&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963252 336294215 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396856 CN1CC[C@@H](C1)NC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C27H24ClFN6O2/c1-34-13-11-18(16-34)31-27(37)23-15-24(35(33-23)19-6-3-2-4-7-19)32-26(36)20-14-17(9-10-21(20)28)25-22(29)8-5-12-30-25/h2-10,12,14-15,18H,11,13,16H2,1H3,(H,31,37)(H,32,36)/t18-/m0/s1 SERCRJMPUISXEW-SFHVURJKSA-N 227120 US9328096, 808 High affinity nerve growth factor receptor [441-796] Human 149 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227120 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227120&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963253 336294216 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396857 CN(C)[C@H]1CC[C@@H](CC1)NC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C30H30ClFN6O2/c1-37(2)21-13-11-20(12-14-21)34-30(40)26-18-27(38(36-26)22-7-4-3-5-8-22)35-29(39)23-17-19(10-15-24(23)31)28-25(32)9-6-16-33-28/h3-10,15-18,20-21H,11-14H2,1-2H3,(H,34,40)(H,35,39)/t20-,21- SBKLLAZPBFNEAD-MEMLXQNLSA-N 227121 US9328096, 809 High affinity nerve growth factor receptor [441-796] Human 76 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227121&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963254 336294217 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396858 Fc1cccnc1-c1ccc(Cl)c(c1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)N[C@H]1CN2CCC1CC2 InChI=1S/C29H26ClFN6O2/c30-22-9-8-19(27-23(31)7-4-12-32-27)15-21(22)28(38)34-26-16-24(35-37(26)20-5-2-1-3-6-20)29(39)33-25-17-36-13-10-18(25)11-14-36/h1-9,12,15-16,18,25H,10-11,13-14,17H2,(H,33,39)(H,34,38)/t25-/m0/s1 FRMLIGLXWYZFOZ-VWLOTQADSA-N 227122 US9328096, 810 High affinity nerve growth factor receptor [441-796] Human 123 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227122 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227122&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963255 336294218 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396859 CC(CN(C)C)NC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C27H26ClFN6O2/c1-17(16-34(2)3)31-27(37)23-15-24(35(33-23)19-8-5-4-6-9-19)32-26(36)20-14-18(11-12-21(20)28)25-22(29)10-7-13-30-25/h4-15,17H,16H2,1-3H3,(H,31,37)(H,32,36) TVXYRRJXLCLISF-UHFFFAOYSA-N 227123 US9328096, 811 High affinity nerve growth factor receptor [441-796] Human 608 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227123 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227123&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963256 336294219 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396860 Fc1cccnc1-c1ccc(Cl)c(c1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NC[C@@H]1CCN2CCC[C@H]12 InChI=1S/C30H28ClFN6O2/c31-23-11-10-19(28-24(32)8-4-13-33-28)16-22(23)29(39)35-27-17-25(36-38(27)21-6-2-1-3-7-21)30(40)34-18-20-12-15-37-14-5-9-26(20)37/h1-4,6-8,10-11,13,16-17,20,26H,5,9,12,14-15,18H2,(H,34,40)(H,35,39)/t20-,26+/m0/s1 GIDYFNOKAXCDGI-RXFWQSSRSA-N 227124 US9328096, 812 High affinity nerve growth factor receptor [441-796] Human 1280 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227124 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227124&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963257 336294220 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396861 Fc1cccnc1-c1ccc(Cl)c(c1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)N[C@H]1CN2CC[C@@H]1C2 InChI=1S/C28H24ClFN6O2/c29-21-9-8-17(26-22(30)7-4-11-31-26)13-20(21)27(37)33-25-14-23(34-36(25)19-5-2-1-3-6-19)28(38)32-24-16-35-12-10-18(24)15-35/h1-9,11,13-14,18,24H,10,12,15-16H2,(H,32,38)(H,33,37)/t18-,24+/m1/s1 MAVBNADNFASPAI-KOSHJBKYSA-N 227125 US9328096, 813 High affinity nerve growth factor receptor [441-796] Human 149 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227125 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227125&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963258 336294221 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396862 CN(C)C1CC(CNC(=O)c2cc(NC(=O)c3cc(ccc3Cl)-c3ncccc3F)n(n2)-c2ccccc2)C1 InChI=1S/C29H28ClFN6O2/c1-36(2)21-13-18(14-21)17-33-29(39)25-16-26(37(35-25)20-7-4-3-5-8-20)34-28(38)22-15-19(10-11-23(22)30)27-24(31)9-6-12-32-27/h3-12,15-16,18,21H,13-14,17H2,1-2H3,(H,33,39)(H,34,38) NXTGGIFVAMSWAW-UHFFFAOYSA-N 227126 US9328096, 814 High affinity nerve growth factor receptor [441-796] Human 359 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227126 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227126&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963259 336294222 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396863 CN(C)C[C@H]1C[C@H](C1)NC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C29H28ClFN6O2/c1-36(2)17-18-13-20(14-18)33-29(39)25-16-26(37(35-25)21-7-4-3-5-8-21)34-28(38)22-15-19(10-11-23(22)30)27-24(31)9-6-12-32-27/h3-12,15-16,18,20H,13-14,17H2,1-2H3,(H,33,39)(H,34,38)/t18-,20+ YWKDRKSIKSPXMQ-PUZFROQSSA-N 227127 US9328096, 815 High affinity nerve growth factor receptor [441-796] Human 116 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227127 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227127&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963260 336294223 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396864 Fc1cccnc1-c1ccc(Cl)c(c1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCC12CCN(CC1)CC2 InChI=1S/C30H28ClFN6O2/c31-23-9-8-20(27-24(32)7-4-13-33-27)17-22(23)28(39)35-26-18-25(36-38(26)21-5-2-1-3-6-21)29(40)34-19-30-10-14-37(15-11-30)16-12-30/h1-9,13,17-18H,10-12,14-16,19H2,(H,34,40)(H,35,39) CMHFWTUXXFPEEJ-UHFFFAOYSA-N 227128 US9328096, 816 High affinity nerve growth factor receptor [441-796] Human 429 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227128 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227128&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963261 336294224 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396865 CN1CCC(CNC(=O)c2cc(NC(=O)c3cc(ccc3Cl)-c3ncccc3F)n(n2)-c2ccccc2)CC1 InChI=1S/C29H28ClFN6O2/c1-36-14-11-19(12-15-36)18-33-29(39)25-17-26(37(35-25)21-6-3-2-4-7-21)34-28(38)22-16-20(9-10-23(22)30)27-24(31)8-5-13-32-27/h2-10,13,16-17,19H,11-12,14-15,18H2,1H3,(H,33,39)(H,34,38) KFLFIALUBZNVNQ-UHFFFAOYSA-N 227129 US9328096, 817 High affinity nerve growth factor receptor [441-796] Human 269 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227129 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227129&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963262 336294225 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396866 CN(C)[C@@H]1COC[C@H]1NC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C28H26ClFN6O3/c1-35(2)24-16-39-15-23(24)32-28(38)22-14-25(36(34-22)18-7-4-3-5-8-18)33-27(37)19-13-17(10-11-20(19)29)26-21(30)9-6-12-31-26/h3-14,23-24H,15-16H2,1-2H3,(H,32,38)(H,33,37)/t23-,24-/m1/s1 QYDFQMIMIFNHMI-DNQXCXABSA-N 227130 US9328096, 818 High affinity nerve growth factor receptor [441-796] Human 138 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227130 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227130&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963263 336294226 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396867 O[C@H]1C[C@H](C1)NC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C26H21ClFN5O3/c27-20-9-8-15(24-21(28)7-4-10-29-24)11-19(20)25(35)31-23-14-22(26(36)30-16-12-18(34)13-16)32-33(23)17-5-2-1-3-6-17/h1-11,14,16,18,34H,12-13H2,(H,30,36)(H,31,35)/t16-,18+ AAIGYDQLJHQJLX-MAEOIBBWSA-N 227131 US9328096, 819 High affinity nerve growth factor receptor [441-796] Human 75.8 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227131 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227131&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962693 336294227 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396868 CC(C)(O)CNC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C26H23ClFN5O3/c1-26(2,36)15-30-25(35)21-14-22(33(32-21)17-7-4-3-5-8-17)31-24(34)18-13-16(10-11-19(18)27)23-20(28)9-6-12-29-23/h3-14,36H,15H2,1-2H3,(H,30,35)(H,31,34) QFDQPCSBPJEEOC-UHFFFAOYSA-N 227132 US9328096, 820 High affinity nerve growth factor receptor [441-796] Human 101 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227132 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227132&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963264 336294228 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396869 Cc1cc(NC(=O)c2cc(NC(=O)c3cc(ccc3Cl)-c3ncccc3F)n(n2)-c2ccccc2)[nH]n1 InChI=1S/C26H19ClFN7O2/c1-15-12-22(33-32-15)30-26(37)21-14-23(35(34-21)17-6-3-2-4-7-17)31-25(36)18-13-16(9-10-19(18)27)24-20(28)8-5-11-29-24/h2-14H,1H3,(H,31,36)(H2,30,32,33,37) UMGVHJFEQWFXOR-UHFFFAOYSA-N 227133 US9328096, 821 High affinity nerve growth factor receptor [441-796] Human 290 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227133 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227133&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963265 336294229 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396870 O[C@H]1CC[C@@H](CC1)NC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C28H25ClFN5O3/c29-22-13-8-17(26-23(30)7-4-14-31-26)15-21(22)27(37)33-25-16-24(34-35(25)19-5-2-1-3-6-19)28(38)32-18-9-11-20(36)12-10-18/h1-8,13-16,18,20,36H,9-12H2,(H,32,38)(H,33,37)/t18-,20- CABIXBDCJSQXLH-KESTWPANSA-N 227134 US9328096, 822 High affinity nerve growth factor receptor [441-796] Human 57.1 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227134 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227134&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963266 336294230 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396871 O[C@@H]1CC[C@@H](C1)NC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C27H23ClFN5O3/c28-21-11-8-16(25-22(29)7-4-12-30-25)13-20(21)26(36)32-24-15-23(27(37)31-17-9-10-19(35)14-17)33-34(24)18-5-2-1-3-6-18/h1-8,11-13,15,17,19,35H,9-10,14H2,(H,31,37)(H,32,36)/t17-,19+/m0/s1 KHYVHCSMSOSNKB-PKOBYXMFSA-N 227135 US9328096, 823 High affinity nerve growth factor receptor [441-796] Human 45.8 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227135 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227135&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963267 336294231 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396872 CC(CO)CNC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C26H23ClFN5O3/c1-16(15-34)14-30-26(36)22-13-23(33(32-22)18-6-3-2-4-7-18)31-25(35)19-12-17(9-10-20(19)27)24-21(28)8-5-11-29-24/h2-13,16,34H,14-15H2,1H3,(H,30,36)(H,31,35) MHWDEPUPJVMBEP-UHFFFAOYSA-N 227136 US9328096, 824 High affinity nerve growth factor receptor [441-796] Human 58.5 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227136 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227136&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963268 336294232 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396873 OC1(CNC(=O)c2cc(NC(=O)c3cc(ccc3Cl)-c3ncccc3F)n(n2)-c2ccccc2)CC1 InChI=1S/C26H21ClFN5O3/c27-19-9-8-16(23-20(28)7-4-12-29-23)13-18(19)24(34)31-22-14-21(25(35)30-15-26(36)10-11-26)32-33(22)17-5-2-1-3-6-17/h1-9,12-14,36H,10-11,15H2,(H,30,35)(H,31,34) UOUQJJDAMFLHQK-UHFFFAOYSA-N 227137 US9328096, 825 High affinity nerve growth factor receptor [441-796] Human 89.5 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227137 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227137&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963269 336294233 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396874 Fc1cccnc1-c1ccc(Cl)c(c1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCc1cnc[nH]1 InChI=1S/C26H19ClFN7O2/c27-20-9-8-16(24-21(28)7-4-10-30-24)11-19(20)25(36)33-23-12-22(26(37)31-14-17-13-29-15-32-17)34-35(23)18-5-2-1-3-6-18/h1-13,15H,14H2,(H,29,32)(H,31,37)(H,33,36) LLJJGVAGSXSNLW-UHFFFAOYSA-N 227138 US9328096, 826 High affinity nerve growth factor receptor [441-796] Human 34.3 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227138 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227138&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963270 336294234 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396875 CC(F)(F)CNC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C25H19ClF3N5O2/c1-25(28,29)14-31-24(36)20-13-21(34(33-20)16-6-3-2-4-7-16)32-23(35)17-12-15(9-10-18(17)26)22-19(27)8-5-11-30-22/h2-13H,14H2,1H3,(H,31,36)(H,32,35) UNPRGFVVLLNIQF-UHFFFAOYSA-N 227139 US9328096, 827 High affinity nerve growth factor receptor [441-796] Human 67.9 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227139 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227139&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963271 336294235 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396876 O[C@H]1CC[C@H](CC1)NC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C28H25ClFN5O3/c29-22-13-8-17(26-23(30)7-4-14-31-26)15-21(22)27(37)33-25-16-24(34-35(25)19-5-2-1-3-6-19)28(38)32-18-9-11-20(36)12-10-18/h1-8,13-16,18,20,36H,9-12H2,(H,32,38)(H,33,37)/t18-,20+ CABIXBDCJSQXLH-PUZFROQSSA-N 227140 US9328096, 828 High affinity nerve growth factor receptor [441-796] Human 67.1 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227140 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227140&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963266 336294236 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396877 OC1CC(C1)NC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C26H21ClFN5O3/c27-20-9-8-15(24-21(28)7-4-10-29-24)11-19(20)25(35)31-23-14-22(26(36)30-16-12-18(34)13-16)32-33(23)17-5-2-1-3-6-17/h1-11,14,16,18,34H,12-13H2,(H,30,36)(H,31,35) AAIGYDQLJHQJLX-UHFFFAOYSA-N 227141 US9328096, 829 High affinity nerve growth factor receptor [441-796] Human 82.2 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227141 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227141&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962693 336294237 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396878 OC1(CNC(=O)c2cc(NC(=O)c3cc(ccc3Cl)-c3ncccc3F)n(n2)-c2ccccc2)COC1 InChI=1S/C26H21ClFN5O4/c27-19-9-8-16(23-20(28)7-4-10-29-23)11-18(19)24(34)31-22-12-21(25(35)30-13-26(36)14-37-15-26)32-33(22)17-5-2-1-3-6-17/h1-12,36H,13-15H2,(H,30,35)(H,31,34) CTWXMNAPPSUMMW-UHFFFAOYSA-N 227142 US9328096, 830 High affinity nerve growth factor receptor [441-796] Human 73.7 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227142 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227142&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963272 336294238 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396879 COCC(O)CNC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C26H23ClFN5O4/c1-37-15-18(34)14-30-26(36)22-13-23(33(32-22)17-6-3-2-4-7-17)31-25(35)19-12-16(9-10-20(19)27)24-21(28)8-5-11-29-24/h2-13,18,34H,14-15H2,1H3,(H,30,36)(H,31,35) AOWDHIYBXJODBS-UHFFFAOYSA-N 227143 US9328096, 831 High affinity nerve growth factor receptor [441-796] Human 128 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227143 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227143&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963273 336294239 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396880 OC[C@H]1C[C@H](C1)NC(=O)c1cc(NC(=O)c2cc(ccc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C27H23ClFN5O3/c28-21-9-8-17(25-22(29)7-4-10-30-25)13-20(21)26(36)32-24-14-23(27(37)31-18-11-16(12-18)15-35)33-34(24)19-5-2-1-3-6-19/h1-10,13-14,16,18,35H,11-12,15H2,(H,31,37)(H,32,36)/t16-,18+ LYHCNIHMFKXBQI-MAEOIBBWSA-N 227144 US9328096, 832 High affinity nerve growth factor receptor [441-796] Human 82.6 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227144 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227144&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962699 336294240 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396881 Fc1cccnc1-c1ccc(Cl)c(c1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCC1COC1 InChI=1S/C26H21ClFN5O3/c27-20-9-8-17(24-21(28)7-4-10-29-24)11-19(20)25(34)31-23-12-22(26(35)30-13-16-14-36-15-16)32-33(23)18-5-2-1-3-6-18/h1-12,16H,13-15H2,(H,30,35)(H,31,34) NFKKQPLTSYTUGG-UHFFFAOYSA-N 227145 US9328096, 833 High affinity nerve growth factor receptor [441-796] Human 79.3 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227145 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227145&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963274 336294241 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396882 O[C@H]1CC[C@H](CC1)NC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C28H24ClF2N5O3/c29-21-14-23(31)20(26-22(30)7-4-12-32-26)13-19(21)27(38)34-25-15-24(35-36(25)17-5-2-1-3-6-17)28(39)33-16-8-10-18(37)11-9-16/h1-7,12-16,18,37H,8-11H2,(H,33,39)(H,34,38)/t16-,18+ WDHUBNPJVCIQEU-MAEOIBBWSA-N 227146 US9328096, 834 High affinity nerve growth factor receptor [441-796] Human 9.71 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227146 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227146&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962665 336294242 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396883 O[C@@H]1COC[C@H]1NC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C26H20ClF2N5O4/c27-17-10-19(29)16(24-18(28)7-4-8-30-24)9-15(17)25(36)32-23-11-20(26(37)31-21-12-38-13-22(21)35)33-34(23)14-5-2-1-3-6-14/h1-11,21-22,35H,12-13H2,(H,31,37)(H,32,36)/t21-,22-/m1/s1 YKWMLKMCCVRPQI-FGZHOGPDSA-N 227147 US9328096, 835 High affinity nerve growth factor receptor [441-796] Human 19.8 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227147 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227147&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963275 336294243 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396884 Nc1cc(CNC(=O)c2cc(NC(=O)c3cc(c(F)cc3Cl)-c3ncccc3F)n(n2)-c2ccccc2)ccn1 InChI=1S/C28H20ClF2N7O2/c29-20-13-22(31)19(26-21(30)7-4-9-34-26)12-18(20)27(39)36-25-14-23(37-38(25)17-5-2-1-3-6-17)28(40)35-15-16-8-10-33-24(32)11-16/h1-14H,15H2,(H2,32,33)(H,35,40)(H,36,39) NMHKWBHIPKHDOK-UHFFFAOYSA-N 227148 US9328096, 836 High affinity nerve growth factor receptor [441-796] Human 1.04 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227148 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227148&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963276 336294244 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396885 COCCNC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1 InChI=1S/C25H20ClF2N5O3/c1-36-11-10-30-25(35)21-14-22(33(32-21)15-6-3-2-4-7-15)31-24(34)16-12-17(20(28)13-18(16)26)23-19(27)8-5-9-29-23/h2-9,12-14H,10-11H2,1H3,(H,30,35)(H,31,34) JTUDIGCFYKINBK-UHFFFAOYSA-N 227149 US9328096, 837 High affinity nerve growth factor receptor [441-796] Human 21.4 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227149 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227149&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963277 336294245 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396886 Fc1cccnc1-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)NCc2ccnnc2)c(Cl)cc1F InChI=1S/C27H18ClF2N7O2/c28-20-12-22(30)19(25-21(29)7-4-9-31-25)11-18(20)26(38)35-24-13-23(36-37(24)17-5-2-1-3-6-17)27(39)32-14-16-8-10-33-34-15-16/h1-13,15H,14H2,(H,32,39)(H,35,38) NQNCVHVGEHWMCH-UHFFFAOYSA-N 227150 US9328096, 838 High affinity nerve growth factor receptor [441-796] Human 7.49 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227150 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227150&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963278 336294246 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396887 CC(CO)NC(=O)c1cc(NC(=O)c2cc(c(Cl)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C25H21Cl2N5O3/c1-15(14-33)29-25(35)22-13-23(32(31-22)16-7-3-2-4-8-16)30-24(34)18-11-17(19(26)12-20(18)27)21-9-5-6-10-28-21/h2-13,15,33H,14H2,1H3,(H,29,35)(H,30,34) IQHHAPKSJWCKBQ-UHFFFAOYSA-N 227151 US9328096, 839 High affinity nerve growth factor receptor [441-796] Human 10.2 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227151 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227151&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 118497108 336294247 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396888 N[C@H]1C[C@H](C1)NC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ccccn2)n(n1)-c1ccccc1 InChI=1S/C26H22ClFN6O2/c27-20-13-21(28)19(22-8-4-5-9-30-22)12-18(20)25(35)32-24-14-23(26(36)31-16-10-15(29)11-16)33-34(24)17-6-2-1-3-7-17/h1-9,12-16H,10-11,29H2,(H,31,36)(H,32,35)/t15-,16+ RMQGHRVQIJLFRR-IYBDPMFKSA-N 227152 US9328096, 840 High affinity nerve growth factor receptor [441-796] Human 104 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227152 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227152&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126962685 336294248 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 396889 Fc1cc(Cl)c(cc1-c1ccccn1)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCc1nnco1 InChI=1S/C25H17ClFN7O3/c26-18-11-19(27)17(20-8-4-5-9-28-20)10-16(18)24(35)31-22-12-21(25(36)29-13-23-32-30-14-37-23)33-34(22)15-6-2-1-3-7-15/h1-12,14H,13H2,(H,29,36)(H,31,35) IFPMTARUWRTBHF-UHFFFAOYSA-N 227153 US9328096, 841 High affinity nerve growth factor receptor [441-796] Human 176 37.00 C US Patent 10.7270/Q2FN152J aid1802770 US9328096 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS 5/3/2016 5/15/2017 Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=227153 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=394&target=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=227153&enzyme=High+affinity+nerve+growth+factor+receptor+%5B441-796%5D&column=ki&startPg=0&Increment=50&submit=Search 126963279 336294249 1 KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 4AOJ,4F0I,4PMM,4PMP,4PMS,4PMT,4YNE,4YPS,5H3Q,5I8A,5JFS,5JFV,5JFW,5JFX,5KMI,5KMJ,5KMK,5KML,5KMM,5KMN,5KMO,5KVT,5WR7,6D1Y,6D1Z,6D20,6D22,6DKB,6DKG,6DKI,6DKW,6IQN,6J5L,6NPT,6NSP,6NSS,6PL1,6PL2,6PL3,6PL4,6PMA,6PMB,6PMC,6PME,7VKO,7XAF,7XBI High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7