BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Date of publication Date in BindingDB Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID PubChem SID ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence 1 PDB ID(s) of Target Chain 1 UniProt (SwissProt) Recommended Name of Target Chain 1 UniProt (SwissProt) Entry Name of Target Chain 1 UniProt (SwissProt) Primary ID of Target Chain 1 UniProt (SwissProt) Secondary ID(s) of Target Chain 1 UniProt (SwissProt) Alternative ID(s) of Target Chain 1 UniProt (TrEMBL) Submitted Name of Target Chain 1 UniProt (TrEMBL) Entry Name of Target Chain 1 UniProt (TrEMBL) Primary ID of Target Chain 1 UniProt (TrEMBL) Secondary ID(s) of Target Chain 1 UniProt (TrEMBL) Alternative ID(s) of Target Chain 1 BindingDB Target Chain Sequence 2 PDB ID(s) of Target Chain 2 UniProt (SwissProt) Recommended Name of Target Chain 2 UniProt (SwissProt) Entry Name of Target Chain 2 UniProt (SwissProt) Primary ID of Target Chain 2 UniProt (SwissProt) Secondary ID(s) of Target Chain 2 UniProt (SwissProt) Alternative ID(s) of Target Chain 2 UniProt (TrEMBL) Submitted Name of Target Chain 2 UniProt (TrEMBL) Entry Name of Target Chain 2 UniProt (TrEMBL) Primary ID of Target Chain 2 UniProt (TrEMBL) Secondary ID(s) of Target Chain 2 UniProt (TrEMBL) Alternative ID(s) of Target Chain 2 BindingDB Target Chain Sequence 3 PDB ID(s) of Target Chain 3 UniProt (SwissProt) Recommended Name of Target Chain 3 UniProt (SwissProt) Entry Name of Target Chain 3 UniProt (SwissProt) Primary ID of Target Chain 3 UniProt (SwissProt) Secondary ID(s) of Target Chain 3 UniProt (SwissProt) Alternative ID(s) of Target Chain 3 UniProt (TrEMBL) Submitted Name of Target Chain 3 UniProt (TrEMBL) Entry Name of Target Chain 3 UniProt (TrEMBL) Primary ID of Target Chain 3 UniProt (TrEMBL) Secondary ID(s) of Target Chain 3 UniProt (TrEMBL) Alternative ID(s) of Target Chain 3 BindingDB Target Chain Sequence 4 PDB ID(s) of Target Chain 4 UniProt (SwissProt) Recommended Name of Target Chain 4 UniProt (SwissProt) Entry Name of Target Chain 4 UniProt (SwissProt) Primary ID of Target Chain 4 UniProt (SwissProt) Secondary ID(s) of Target Chain 4 UniProt (SwissProt) Alternative ID(s) of Target Chain 4 UniProt (TrEMBL) Submitted Name of Target Chain 4 UniProt (TrEMBL) Entry Name of Target Chain 4 UniProt (TrEMBL) Primary ID of Target Chain 4 UniProt (TrEMBL) Secondary ID(s) of Target Chain 4 UniProt (TrEMBL) Alternative ID(s) of Target Chain 4 BindingDB Target Chain Sequence 5 PDB ID(s) of Target Chain 5 UniProt (SwissProt) Recommended Name of Target Chain 5 UniProt (SwissProt) Entry Name of Target Chain 5 UniProt (SwissProt) Primary ID of Target Chain 5 UniProt (SwissProt) Secondary ID(s) of Target Chain 5 UniProt (SwissProt) Alternative ID(s) of Target Chain 5 UniProt (TrEMBL) Submitted Name of Target Chain 5 UniProt (TrEMBL) Entry Name of Target Chain 5 UniProt (TrEMBL) Primary ID of Target Chain 5 UniProt (TrEMBL) Secondary ID(s) of Target Chain 5 UniProt (TrEMBL) Alternative ID(s) of Target Chain 5 BindingDB Target Chain Sequence 6 PDB ID(s) of Target Chain 6 UniProt (SwissProt) Recommended Name of Target Chain 6 UniProt (SwissProt) Entry Name of Target Chain 6 UniProt (SwissProt) Primary ID of Target Chain 6 UniProt (SwissProt) Secondary ID(s) of Target Chain 6 UniProt (SwissProt) Alternative ID(s) of Target Chain 6 UniProt (TrEMBL) Submitted Name of Target Chain 6 UniProt (TrEMBL) Entry Name of Target Chain 6 UniProt (TrEMBL) Primary ID of Target Chain 6 UniProt (TrEMBL) Secondary ID(s) of Target Chain 6 UniProt (TrEMBL) Alternative ID(s) of Target Chain 6 BindingDB Target Chain Sequence 7 PDB ID(s) of Target Chain 7 UniProt (SwissProt) Recommended Name of Target Chain 7 UniProt (SwissProt) Entry Name of Target Chain 7 UniProt (SwissProt) Primary ID of Target Chain 7 UniProt (SwissProt) Secondary ID(s) of Target Chain 7 UniProt (SwissProt) Alternative ID(s) of Target Chain 7 UniProt (TrEMBL) Submitted Name of Target Chain 7 UniProt (TrEMBL) Entry Name of Target Chain 7 UniProt (TrEMBL) Primary ID of Target Chain 7 UniProt (TrEMBL) Secondary ID(s) of Target Chain 7 UniProt (TrEMBL) Alternative ID(s) of Target Chain 7 BindingDB Target Chain Sequence 8 PDB ID(s) of Target Chain 8 UniProt (SwissProt) Recommended Name of Target Chain 8 UniProt (SwissProt) Entry Name of Target Chain 8 UniProt (SwissProt) Primary ID of Target Chain 8 UniProt (SwissProt) Secondary ID(s) of Target Chain 8 UniProt (SwissProt) Alternative ID(s) of Target Chain 8 UniProt (TrEMBL) Submitted Name of Target Chain 8 UniProt (TrEMBL) Entry Name of Target Chain 8 UniProt (TrEMBL) Primary ID of Target Chain 8 UniProt (TrEMBL) Secondary ID(s) of Target Chain 8 UniProt (TrEMBL) Alternative ID(s) of Target Chain 8 BindingDB Target Chain Sequence 9 PDB ID(s) of Target Chain 9 UniProt (SwissProt) Recommended Name of Target Chain 9 UniProt (SwissProt) Entry Name of Target Chain 9 UniProt (SwissProt) Primary ID of Target Chain 9 UniProt (SwissProt) Secondary ID(s) of Target Chain 9 UniProt (SwissProt) Alternative ID(s) of Target Chain 9 UniProt (TrEMBL) Submitted Name of Target Chain 9 UniProt (TrEMBL) Entry Name of Target Chain 9 UniProt (TrEMBL) Primary ID of Target Chain 9 UniProt (TrEMBL) Secondary ID(s) of Target Chain 9 UniProt (TrEMBL) Alternative ID(s) of Target Chain 9 BindingDB Target Chain Sequence 10 PDB ID(s) of Target Chain 10 UniProt (SwissProt) Recommended Name of Target Chain 10 UniProt (SwissProt) Entry Name of Target Chain 10 UniProt (SwissProt) Primary ID of Target Chain 10 UniProt (SwissProt) Secondary ID(s) of Target Chain 10 UniProt (SwissProt) Alternative ID(s) of Target Chain 10 UniProt (TrEMBL) Submitted Name of Target Chain 10 UniProt (TrEMBL) Entry Name of Target Chain 10 UniProt (TrEMBL) Primary ID of Target Chain 10 UniProt (TrEMBL) Secondary ID(s) of Target Chain 10 UniProt (TrEMBL) Alternative ID(s) of Target Chain 10 BindingDB Target Chain Sequence 11 PDB ID(s) of Target Chain 11 UniProt (SwissProt) Recommended Name of Target Chain 11 UniProt (SwissProt) Entry Name of Target Chain 11 UniProt (SwissProt) Primary ID of Target Chain 11 UniProt (SwissProt) Secondary ID(s) of Target Chain 11 UniProt (SwissProt) Alternative ID(s) of Target Chain 11 UniProt (TrEMBL) Submitted Name of Target Chain 11 UniProt (TrEMBL) Entry Name of Target Chain 11 UniProt (TrEMBL) Primary ID of Target Chain 11 UniProt (TrEMBL) Secondary ID(s) of Target Chain 11 UniProt (TrEMBL) Alternative ID(s) of Target Chain 11 BindingDB Target Chain Sequence 12 PDB ID(s) of Target Chain 12 UniProt (SwissProt) Recommended Name of Target Chain 12 UniProt (SwissProt) Entry Name of Target Chain 12 UniProt (SwissProt) Primary ID of Target Chain 12 UniProt (SwissProt) Secondary ID(s) of Target Chain 12 UniProt (SwissProt) Alternative ID(s) of Target Chain 12 UniProt (TrEMBL) Submitted Name of Target Chain 12 UniProt (TrEMBL) Entry Name of Target Chain 12 UniProt (TrEMBL) Primary ID of Target Chain 12 UniProt (TrEMBL) Secondary ID(s) of Target Chain 12 UniProt (TrEMBL) Alternative ID(s) of Target Chain 12 BindingDB Target Chain Sequence 13 PDB ID(s) of Target Chain 13 UniProt (SwissProt) Recommended Name of Target Chain 13 UniProt (SwissProt) Entry Name of Target Chain 13 UniProt (SwissProt) Primary ID of Target Chain 13 UniProt (SwissProt) Secondary ID(s) of Target Chain 13 UniProt (SwissProt) Alternative ID(s) of Target Chain 13 UniProt (TrEMBL) Submitted Name of Target Chain 13 UniProt (TrEMBL) Entry Name of Target Chain 13 UniProt (TrEMBL) Primary ID of Target Chain 13 UniProt (TrEMBL) Secondary ID(s) of Target Chain 13 UniProt (TrEMBL) Alternative ID(s) of Target Chain 13 BindingDB Target Chain Sequence 14 PDB ID(s) of Target Chain 14 UniProt (SwissProt) Recommended Name of Target Chain 14 UniProt (SwissProt) Entry Name of Target Chain 14 UniProt (SwissProt) Primary ID of Target Chain 14 UniProt (SwissProt) Secondary ID(s) of Target Chain 14 UniProt (SwissProt) Alternative ID(s) of Target Chain 14 UniProt (TrEMBL) Submitted Name of Target Chain 14 UniProt (TrEMBL) Entry Name of Target Chain 14 UniProt (TrEMBL) Primary ID of Target Chain 14 UniProt (TrEMBL) Secondary ID(s) of Target Chain 14 UniProt (TrEMBL) Alternative ID(s) of Target Chain 14 BindingDB Target Chain Sequence 15 PDB ID(s) of Target Chain 15 UniProt (SwissProt) Recommended Name of Target Chain 15 UniProt (SwissProt) Entry Name of Target Chain 15 UniProt (SwissProt) Primary ID of Target Chain 15 UniProt (SwissProt) Secondary ID(s) of Target Chain 15 UniProt (SwissProt) Alternative ID(s) of Target Chain 15 UniProt (TrEMBL) Submitted Name of Target Chain 15 UniProt (TrEMBL) Entry Name of Target Chain 15 UniProt (TrEMBL) Primary ID of Target Chain 15 UniProt (TrEMBL) Secondary ID(s) of Target Chain 15 UniProt (TrEMBL) Alternative ID(s) of Target Chain 15 BindingDB Target Chain Sequence 16 PDB ID(s) of Target Chain 16 UniProt (SwissProt) Recommended Name of Target Chain 16 UniProt (SwissProt) Entry Name of Target Chain 16 UniProt (SwissProt) Primary ID of Target Chain 16 UniProt (SwissProt) Secondary ID(s) of Target Chain 16 UniProt (SwissProt) Alternative ID(s) of Target Chain 16 UniProt (TrEMBL) Submitted Name of Target Chain 16 UniProt (TrEMBL) Entry Name of Target Chain 16 UniProt (TrEMBL) Primary ID of Target Chain 16 UniProt (TrEMBL) Secondary ID(s) of Target Chain 16 UniProt (TrEMBL) Alternative ID(s) of Target Chain 16 BindingDB Target Chain Sequence 17 PDB ID(s) of Target Chain 17 UniProt (SwissProt) Recommended Name of Target Chain 17 UniProt (SwissProt) Entry Name of Target Chain 17 UniProt (SwissProt) Primary ID of Target Chain 17 UniProt (SwissProt) Secondary ID(s) of Target Chain 17 UniProt (SwissProt) Alternative ID(s) of Target Chain 17 UniProt (TrEMBL) Submitted Name of Target Chain 17 UniProt (TrEMBL) Entry Name of Target Chain 17 UniProt (TrEMBL) Primary ID of Target Chain 17 UniProt (TrEMBL) Secondary ID(s) of Target Chain 17 UniProt (TrEMBL) Alternative ID(s) of Target Chain 17 BindingDB Target Chain Sequence 18 PDB ID(s) of Target Chain 18 UniProt (SwissProt) Recommended Name of Target Chain 18 UniProt (SwissProt) Entry Name of Target Chain 18 UniProt (SwissProt) Primary ID of Target Chain 18 UniProt (SwissProt) Secondary ID(s) of Target Chain 18 UniProt (SwissProt) Alternative ID(s) of Target Chain 18 UniProt (TrEMBL) Submitted Name of Target Chain 18 UniProt (TrEMBL) Entry Name of Target Chain 18 UniProt (TrEMBL) Primary ID of Target Chain 18 UniProt (TrEMBL) Secondary ID(s) of Target Chain 18 UniProt (TrEMBL) Alternative ID(s) of Target Chain 18 BindingDB Target Chain Sequence 19 PDB ID(s) of Target Chain 19 UniProt (SwissProt) Recommended Name of Target Chain 19 UniProt (SwissProt) Entry Name of Target Chain 19 UniProt (SwissProt) Primary ID of Target Chain 19 UniProt (SwissProt) Secondary ID(s) of Target Chain 19 UniProt (SwissProt) Alternative ID(s) of Target Chain 19 UniProt (TrEMBL) Submitted Name of Target Chain 19 UniProt (TrEMBL) Entry Name of Target Chain 19 UniProt (TrEMBL) Primary ID of Target Chain 19 UniProt (TrEMBL) Secondary ID(s) of Target Chain 19 UniProt (TrEMBL) Alternative ID(s) of Target Chain 19 BindingDB Target Chain Sequence 20 PDB ID(s) of Target Chain 20 UniProt (SwissProt) Recommended Name of Target Chain 20 UniProt (SwissProt) Entry Name of Target Chain 20 UniProt (SwissProt) Primary ID of Target Chain 20 UniProt (SwissProt) Secondary ID(s) of Target Chain 20 UniProt (SwissProt) Alternative ID(s) of Target Chain 20 UniProt (TrEMBL) Submitted Name of Target Chain 20 UniProt (TrEMBL) Entry Name of Target Chain 20 UniProt (TrEMBL) Primary ID of Target Chain 20 UniProt (TrEMBL) Secondary ID(s) of Target Chain 20 UniProt (TrEMBL) Alternative ID(s) of Target Chain 20 BindingDB Target Chain Sequence 21 PDB ID(s) of Target Chain 21 UniProt (SwissProt) Recommended Name of Target Chain 21 UniProt (SwissProt) Entry Name of Target Chain 21 UniProt (SwissProt) Primary ID of Target Chain 21 UniProt (SwissProt) Secondary ID(s) of Target Chain 21 UniProt (SwissProt) Alternative ID(s) of Target Chain 21 UniProt (TrEMBL) Submitted Name of Target Chain 21 UniProt (TrEMBL) Entry Name of Target Chain 21 UniProt (TrEMBL) Primary ID of Target Chain 21 UniProt (TrEMBL) Secondary ID(s) of Target Chain 21 UniProt (TrEMBL) Alternative ID(s) of Target Chain 21 BindingDB Target Chain Sequence 22 PDB ID(s) of Target Chain 22 UniProt (SwissProt) Recommended Name of Target Chain 22 UniProt (SwissProt) Entry Name of Target Chain 22 UniProt (SwissProt) Primary ID of Target Chain 22 UniProt (SwissProt) Secondary ID(s) of Target Chain 22 UniProt (SwissProt) Alternative ID(s) of Target Chain 22 UniProt (TrEMBL) Submitted Name of Target Chain 22 UniProt (TrEMBL) Entry Name of Target Chain 22 UniProt (TrEMBL) Primary ID of Target Chain 22 UniProt (TrEMBL) Secondary ID(s) of Target Chain 22 UniProt (TrEMBL) Alternative ID(s) of Target Chain 22 BindingDB Target Chain Sequence 23 PDB ID(s) of Target Chain 23 UniProt (SwissProt) Recommended Name of Target Chain 23 UniProt (SwissProt) Entry Name of Target Chain 23 UniProt (SwissProt) Primary ID of Target Chain 23 UniProt (SwissProt) Secondary ID(s) of Target Chain 23 UniProt (SwissProt) Alternative ID(s) of Target Chain 23 UniProt (TrEMBL) Submitted Name of Target Chain 23 UniProt (TrEMBL) Entry Name of Target Chain 23 UniProt (TrEMBL) Primary ID of Target Chain 23 UniProt (TrEMBL) Secondary ID(s) of Target Chain 23 UniProt (TrEMBL) Alternative ID(s) of Target Chain 23 BindingDB Target Chain Sequence 24 PDB ID(s) of Target Chain 24 UniProt (SwissProt) Recommended Name of Target Chain 24 UniProt (SwissProt) Entry Name of Target Chain 24 UniProt (SwissProt) Primary ID of Target Chain 24 UniProt (SwissProt) Secondary ID(s) of Target Chain 24 UniProt (SwissProt) Alternative ID(s) of Target Chain 24 UniProt (TrEMBL) Submitted Name of Target Chain 24 UniProt (TrEMBL) Entry Name of Target Chain 24 UniProt (TrEMBL) Primary ID of Target Chain 24 UniProt (TrEMBL) Secondary ID(s) of Target Chain 24 UniProt (TrEMBL) Alternative ID(s) of Target Chain 24 BindingDB Target Chain Sequence 25 PDB ID(s) of Target Chain 25 UniProt (SwissProt) Recommended Name of Target Chain 25 UniProt (SwissProt) Entry Name of Target Chain 25 UniProt (SwissProt) Primary ID of Target Chain 25 UniProt (SwissProt) Secondary ID(s) of Target Chain 25 UniProt (SwissProt) Alternative ID(s) of Target Chain 25 UniProt (TrEMBL) Submitted Name of Target Chain 25 UniProt (TrEMBL) Entry Name of Target Chain 25 UniProt (TrEMBL) Primary ID of Target Chain 25 UniProt (TrEMBL) Secondary ID(s) of Target Chain 25 UniProt (TrEMBL) Alternative ID(s) of Target Chain 25 BindingDB Target Chain Sequence 26 PDB ID(s) of Target Chain 26 UniProt (SwissProt) Recommended Name of Target Chain 26 UniProt (SwissProt) Entry Name of Target Chain 26 UniProt (SwissProt) Primary ID of Target Chain 26 UniProt (SwissProt) Secondary ID(s) of Target Chain 26 UniProt (SwissProt) Alternative ID(s) of Target Chain 26 UniProt (TrEMBL) Submitted Name of Target Chain 26 UniProt (TrEMBL) Entry Name of Target Chain 26 UniProt (TrEMBL) Primary ID of Target Chain 26 UniProt (TrEMBL) Secondary ID(s) of Target Chain 26 UniProt (TrEMBL) Alternative ID(s) of Target Chain 26 BindingDB Target Chain Sequence 27 PDB ID(s) of Target Chain 27 UniProt (SwissProt) Recommended Name of Target Chain 27 UniProt (SwissProt) Entry Name of Target Chain 27 UniProt (SwissProt) Primary ID of Target Chain 27 UniProt (SwissProt) Secondary ID(s) of Target Chain 27 UniProt (SwissProt) Alternative ID(s) of Target Chain 27 UniProt (TrEMBL) Submitted Name of Target Chain 27 UniProt (TrEMBL) Entry Name of Target Chain 27 UniProt (TrEMBL) Primary ID of Target Chain 27 UniProt (TrEMBL) Secondary ID(s) of Target Chain 27 UniProt (TrEMBL) Alternative ID(s) of Target Chain 27 BindingDB Target Chain Sequence 28 PDB ID(s) of Target Chain 28 UniProt (SwissProt) Recommended Name of Target Chain 28 UniProt (SwissProt) Entry Name of Target Chain 28 UniProt (SwissProt) Primary ID of Target Chain 28 UniProt (SwissProt) Secondary ID(s) of Target Chain 28 UniProt (SwissProt) Alternative ID(s) of Target Chain 28 UniProt (TrEMBL) Submitted Name of Target Chain 28 UniProt (TrEMBL) Entry Name of Target Chain 28 UniProt (TrEMBL) Primary ID of Target Chain 28 UniProt (TrEMBL) Secondary ID(s) of Target Chain 28 UniProt (TrEMBL) Alternative ID(s) of Target Chain 28 BindingDB Target Chain Sequence 29 PDB ID(s) of Target Chain 29 UniProt (SwissProt) Recommended Name of Target Chain 29 UniProt (SwissProt) Entry Name of Target Chain 29 UniProt (SwissProt) Primary ID of Target Chain 29 UniProt (SwissProt) Secondary ID(s) of Target Chain 29 UniProt (SwissProt) Alternative ID(s) of Target Chain 29 UniProt (TrEMBL) Submitted Name of Target Chain 29 UniProt (TrEMBL) Entry Name of Target Chain 29 UniProt (TrEMBL) Primary ID of Target Chain 29 UniProt (TrEMBL) Secondary ID(s) of Target Chain 29 UniProt (TrEMBL) Alternative ID(s) of Target Chain 29 BindingDB Target Chain Sequence 30 PDB ID(s) of Target Chain 30 UniProt (SwissProt) Recommended Name of Target Chain 30 UniProt (SwissProt) Entry Name of Target Chain 30 UniProt (SwissProt) Primary ID of Target Chain 30 UniProt (SwissProt) Secondary ID(s) of Target Chain 30 UniProt (SwissProt) Alternative ID(s) of Target Chain 30 UniProt (TrEMBL) Submitted Name of Target Chain 30 UniProt (TrEMBL) Entry Name of Target Chain 30 UniProt (TrEMBL) Primary ID of Target Chain 30 UniProt (TrEMBL) Secondary ID(s) of Target Chain 30 UniProt (TrEMBL) Alternative ID(s) of Target Chain 30 BindingDB Target Chain Sequence 31 PDB ID(s) of Target Chain 31 UniProt (SwissProt) Recommended Name of Target Chain 31 UniProt (SwissProt) Entry Name of Target Chain 31 UniProt (SwissProt) Primary ID of Target Chain 31 UniProt (SwissProt) Secondary ID(s) of Target Chain 31 UniProt (SwissProt) Alternative ID(s) of Target Chain 31 UniProt (TrEMBL) Submitted Name of Target Chain 31 UniProt (TrEMBL) Entry Name of Target Chain 31 UniProt (TrEMBL) Primary ID of Target Chain 31 UniProt (TrEMBL) Secondary ID(s) of Target Chain 31 UniProt (TrEMBL) Alternative ID(s) of Target Chain 31 BindingDB Target Chain Sequence 32 PDB ID(s) of Target Chain 32 UniProt (SwissProt) Recommended Name of Target Chain 32 UniProt (SwissProt) Entry Name of Target Chain 32 UniProt (SwissProt) Primary ID of Target Chain 32 UniProt (SwissProt) Secondary ID(s) of Target Chain 32 UniProt (SwissProt) Alternative ID(s) of Target Chain 32 UniProt (TrEMBL) Submitted Name of Target Chain 32 UniProt (TrEMBL) Entry Name of Target Chain 32 UniProt (TrEMBL) Primary ID of Target Chain 32 UniProt (TrEMBL) Secondary ID(s) of Target Chain 32 UniProt (TrEMBL) Alternative ID(s) of Target Chain 32 BindingDB Target Chain Sequence 33 PDB ID(s) of Target Chain 33 UniProt (SwissProt) Recommended Name of Target Chain 33 UniProt (SwissProt) Entry Name of Target Chain 33 UniProt (SwissProt) Primary ID of Target Chain 33 UniProt (SwissProt) Secondary ID(s) of Target Chain 33 UniProt (SwissProt) Alternative ID(s) of Target Chain 33 UniProt (TrEMBL) Submitted Name of Target Chain 33 UniProt (TrEMBL) Entry Name of Target Chain 33 UniProt (TrEMBL) Primary ID of Target Chain 33 UniProt (TrEMBL) Secondary ID(s) of Target Chain 33 UniProt (TrEMBL) Alternative ID(s) of Target Chain 33 BindingDB Target Chain Sequence 34 PDB ID(s) of Target Chain 34 UniProt (SwissProt) Recommended Name of Target Chain 34 UniProt (SwissProt) Entry Name of Target Chain 34 UniProt (SwissProt) Primary ID of Target Chain 34 UniProt (SwissProt) Secondary ID(s) of Target Chain 34 UniProt (SwissProt) Alternative ID(s) of Target Chain 34 UniProt (TrEMBL) Submitted Name of Target Chain 34 UniProt (TrEMBL) Entry Name of Target Chain 34 UniProt (TrEMBL) Primary ID of Target Chain 34 UniProt (TrEMBL) Secondary ID(s) of Target Chain 34 UniProt (TrEMBL) Alternative ID(s) of Target Chain 34 BindingDB Target Chain Sequence 35 PDB ID(s) of Target Chain 35 UniProt (SwissProt) Recommended Name of Target Chain 35 UniProt (SwissProt) Entry Name of Target Chain 35 UniProt (SwissProt) Primary ID of Target Chain 35 UniProt (SwissProt) Secondary ID(s) of Target Chain 35 UniProt (SwissProt) Alternative ID(s) of Target Chain 35 UniProt (TrEMBL) Submitted Name of Target Chain 35 UniProt (TrEMBL) Entry Name of Target Chain 35 UniProt (TrEMBL) Primary ID of Target Chain 35 UniProt (TrEMBL) Secondary ID(s) of Target Chain 35 UniProt (TrEMBL) Alternative ID(s) of Target Chain 35 BindingDB Target Chain Sequence 36 PDB ID(s) of Target Chain 36 UniProt (SwissProt) Recommended Name of Target Chain 36 UniProt (SwissProt) Entry Name of Target Chain 36 UniProt (SwissProt) Primary ID of Target Chain 36 UniProt (SwissProt) Secondary ID(s) of Target Chain 36 UniProt (SwissProt) Alternative ID(s) of Target Chain 36 UniProt (TrEMBL) Submitted Name of Target Chain 36 UniProt (TrEMBL) Entry Name of Target Chain 36 UniProt (TrEMBL) Primary ID of Target Chain 36 UniProt (TrEMBL) Secondary ID(s) of Target Chain 36 UniProt (TrEMBL) Alternative ID(s) of Target Chain 36 BindingDB Target Chain Sequence 37 PDB ID(s) of Target Chain 37 UniProt (SwissProt) Recommended Name of Target Chain 37 UniProt (SwissProt) Entry Name of Target Chain 37 UniProt (SwissProt) Primary ID of Target Chain 37 UniProt (SwissProt) Secondary ID(s) of Target Chain 37 UniProt (SwissProt) Alternative ID(s) of Target Chain 37 UniProt (TrEMBL) Submitted Name of Target Chain 37 UniProt (TrEMBL) Entry Name of Target Chain 37 UniProt (TrEMBL) Primary ID of Target Chain 37 UniProt (TrEMBL) Secondary ID(s) of Target Chain 37 UniProt (TrEMBL) Alternative ID(s) of Target Chain 37 BindingDB Target Chain Sequence 38 PDB ID(s) of Target Chain 38 UniProt (SwissProt) Recommended Name of Target Chain 38 UniProt (SwissProt) Entry Name of Target Chain 38 UniProt (SwissProt) Primary ID of Target Chain 38 UniProt (SwissProt) Secondary ID(s) of Target Chain 38 UniProt (SwissProt) Alternative ID(s) of Target Chain 38 UniProt (TrEMBL) Submitted Name of Target Chain 38 UniProt (TrEMBL) Entry Name of Target Chain 38 UniProt (TrEMBL) Primary ID of Target Chain 38 UniProt (TrEMBL) Secondary ID(s) of Target Chain 38 UniProt (TrEMBL) Alternative ID(s) of Target Chain 38 BindingDB Target Chain Sequence 39 PDB ID(s) of Target Chain 39 UniProt (SwissProt) Recommended Name of Target Chain 39 UniProt (SwissProt) Entry Name of Target Chain 39 UniProt (SwissProt) Primary ID of Target Chain 39 UniProt (SwissProt) Secondary ID(s) of Target Chain 39 UniProt (SwissProt) Alternative ID(s) of Target Chain 39 UniProt (TrEMBL) Submitted Name of Target Chain 39 UniProt (TrEMBL) Entry Name of Target Chain 39 UniProt (TrEMBL) Primary ID of Target Chain 39 UniProt (TrEMBL) Secondary ID(s) of Target Chain 39 UniProt (TrEMBL) Alternative ID(s) of Target Chain 39 BindingDB Target Chain Sequence 40 PDB ID(s) of Target Chain 40 UniProt (SwissProt) Recommended Name of Target Chain 40 UniProt (SwissProt) Entry Name of Target Chain 40 UniProt (SwissProt) Primary ID of Target Chain 40 UniProt (SwissProt) Secondary ID(s) of Target Chain 40 UniProt (SwissProt) Alternative ID(s) of Target Chain 40 UniProt (TrEMBL) Submitted Name of Target Chain 40 UniProt (TrEMBL) Entry Name of Target Chain 40 UniProt (TrEMBL) Primary ID of Target Chain 40 UniProt (TrEMBL) Secondary ID(s) of Target Chain 40 UniProt (TrEMBL) Alternative ID(s) of Target Chain 40 BindingDB Target Chain Sequence 41 PDB ID(s) of Target Chain 41 UniProt (SwissProt) Recommended Name of Target Chain 41 UniProt (SwissProt) Entry Name of Target Chain 41 UniProt (SwissProt) Primary ID of Target Chain 41 UniProt (SwissProt) Secondary ID(s) of Target Chain 41 UniProt (SwissProt) Alternative ID(s) of Target Chain 41 UniProt (TrEMBL) Submitted Name of Target Chain 41 UniProt (TrEMBL) Entry Name of Target Chain 41 UniProt (TrEMBL) Primary ID of Target Chain 41 UniProt (TrEMBL) Secondary ID(s) of Target Chain 41 UniProt (TrEMBL) Alternative ID(s) of Target Chain 41 BindingDB Target Chain Sequence 42 PDB ID(s) of Target Chain 42 UniProt (SwissProt) Recommended Name of Target Chain 42 UniProt (SwissProt) Entry Name of Target Chain 42 UniProt (SwissProt) Primary ID of Target Chain 42 UniProt (SwissProt) Secondary ID(s) of Target Chain 42 UniProt (SwissProt) Alternative ID(s) of Target Chain 42 UniProt (TrEMBL) Submitted Name of Target Chain 42 UniProt (TrEMBL) Entry Name of Target Chain 42 UniProt (TrEMBL) Primary ID of Target Chain 42 UniProt (TrEMBL) Secondary ID(s) of Target Chain 42 UniProt (TrEMBL) Alternative ID(s) of Target Chain 42 BindingDB Target Chain Sequence 43 PDB ID(s) of Target Chain 43 UniProt (SwissProt) Recommended Name of Target Chain 43 UniProt (SwissProt) Entry Name of Target Chain 43 UniProt (SwissProt) Primary ID of Target Chain 43 UniProt (SwissProt) Secondary ID(s) of Target Chain 43 UniProt (SwissProt) Alternative ID(s) of Target Chain 43 UniProt (TrEMBL) Submitted Name of Target Chain 43 UniProt (TrEMBL) Entry Name of Target Chain 43 UniProt (TrEMBL) Primary ID of Target Chain 43 UniProt (TrEMBL) Secondary ID(s) of Target Chain 43 UniProt (TrEMBL) Alternative ID(s) of Target Chain 43 BindingDB Target Chain Sequence 44 PDB ID(s) of Target Chain 44 UniProt (SwissProt) Recommended Name of Target Chain 44 UniProt (SwissProt) Entry Name of Target Chain 44 UniProt (SwissProt) Primary ID of Target Chain 44 UniProt (SwissProt) Secondary ID(s) of Target Chain 44 UniProt (SwissProt) Alternative ID(s) of Target Chain 44 UniProt (TrEMBL) Submitted Name of Target Chain 44 UniProt (TrEMBL) Entry Name of Target Chain 44 UniProt (TrEMBL) Primary ID of Target Chain 44 UniProt (TrEMBL) Secondary ID(s) of Target Chain 44 UniProt (TrEMBL) Alternative ID(s) of Target Chain 44 BindingDB Target Chain Sequence 45 PDB ID(s) of Target Chain 45 UniProt (SwissProt) Recommended Name of Target Chain 45 UniProt (SwissProt) Entry Name of Target Chain 45 UniProt (SwissProt) Primary ID of Target Chain 45 UniProt (SwissProt) Secondary ID(s) of Target Chain 45 UniProt (SwissProt) Alternative ID(s) of Target Chain 45 UniProt (TrEMBL) Submitted Name of Target Chain 45 UniProt (TrEMBL) Entry Name of Target Chain 45 UniProt (TrEMBL) Primary ID of Target Chain 45 UniProt (TrEMBL) Secondary ID(s) of Target Chain 45 UniProt (TrEMBL) Alternative ID(s) of Target Chain 45 BindingDB Target Chain Sequence 46 PDB ID(s) of Target Chain 46 UniProt (SwissProt) Recommended Name of Target Chain 46 UniProt (SwissProt) Entry Name of Target Chain 46 UniProt (SwissProt) Primary ID of Target Chain 46 UniProt (SwissProt) Secondary ID(s) of Target Chain 46 UniProt (SwissProt) Alternative ID(s) of Target Chain 46 UniProt (TrEMBL) Submitted Name of Target Chain 46 UniProt (TrEMBL) Entry Name of Target Chain 46 UniProt (TrEMBL) Primary ID of Target Chain 46 UniProt (TrEMBL) Secondary ID(s) of Target Chain 46 UniProt (TrEMBL) Alternative ID(s) of Target Chain 46 BindingDB Target Chain Sequence 47 PDB ID(s) of Target Chain 47 UniProt (SwissProt) Recommended Name of Target Chain 47 UniProt (SwissProt) Entry Name of Target Chain 47 UniProt (SwissProt) Primary ID of Target Chain 47 UniProt (SwissProt) Secondary ID(s) of Target Chain 47 UniProt (SwissProt) Alternative ID(s) of Target Chain 47 UniProt (TrEMBL) Submitted Name of Target Chain 47 UniProt (TrEMBL) Entry Name of Target Chain 47 UniProt (TrEMBL) Primary ID of Target Chain 47 UniProt (TrEMBL) Secondary ID(s) of Target Chain 47 UniProt (TrEMBL) Alternative ID(s) of Target Chain 47 BindingDB Target Chain Sequence 48 PDB ID(s) of Target Chain 48 UniProt (SwissProt) Recommended Name of Target Chain 48 UniProt (SwissProt) Entry Name of Target Chain 48 UniProt (SwissProt) Primary ID of Target Chain 48 UniProt (SwissProt) Secondary ID(s) of Target Chain 48 UniProt (SwissProt) Alternative ID(s) of Target Chain 48 UniProt (TrEMBL) Submitted Name of Target Chain 48 UniProt (TrEMBL) Entry Name of Target Chain 48 UniProt (TrEMBL) Primary ID of Target Chain 48 UniProt (TrEMBL) Secondary ID(s) of Target Chain 48 UniProt (TrEMBL) Alternative ID(s) of Target Chain 48 BindingDB Target Chain Sequence 49 PDB ID(s) of Target Chain 49 UniProt (SwissProt) Recommended Name of Target Chain 49 UniProt (SwissProt) Entry Name of Target Chain 49 UniProt (SwissProt) Primary ID of Target Chain 49 UniProt (SwissProt) Secondary ID(s) of Target Chain 49 UniProt (SwissProt) Alternative ID(s) of Target Chain 49 UniProt (TrEMBL) Submitted Name of Target Chain 49 UniProt (TrEMBL) Entry Name of Target Chain 49 UniProt (TrEMBL) Primary ID of Target Chain 49 UniProt (TrEMBL) Secondary ID(s) of Target Chain 49 UniProt (TrEMBL) Alternative ID(s) of Target Chain 49 BindingDB Target Chain Sequence 50 PDB ID(s) of Target Chain 50 UniProt (SwissProt) Recommended Name of Target Chain 50 UniProt (SwissProt) Entry Name of Target Chain 50 UniProt (SwissProt) Primary ID of Target Chain 50 UniProt (SwissProt) Secondary ID(s) of Target Chain 50 UniProt (SwissProt) Alternative ID(s) of Target Chain 50 UniProt (TrEMBL) Submitted Name of Target Chain 50 UniProt (TrEMBL) Entry Name of Target Chain 50 UniProt (TrEMBL) Primary ID of Target Chain 50 UniProt (TrEMBL) Secondary ID(s) of Target Chain 50 UniProt (TrEMBL) Alternative ID(s) of Target Chain 50 237154 Nc1cccc2C(=O)N(Cc12)C1CCC(=O)NC1=O InChI=1S/C13H13N3O3/c14-9-3-1-2-7-8(9)6-16(13(7)19)10-4-5-11(17)15-12(10)18/h1-3,10H,4-6,14H2,(H,15,17,18) GOTYRUGSSMKFNF-UHFFFAOYSA-N 65454 Lenalidomide::US9694015, 6.1::191732-72-6::Revlimid::Revimid::CC-5013::US11530219, Compound Lenalidomide::US20250129088, Compound Lenalidomide::US20250215012, Example Lenalidomide::US20250243210, Compound Lena-NH2::US20250268906, Compound lenalidomide::US20250313547, Example Control-2::US12441708, Example Control-2::US20250320193, Compound lenalidomide::US20260028326, Compound lenalidomide Protein cereblon Homo sapiens 1900 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=65454 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=65454&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 216326 350083085 DB00480 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237155 CC1(C)CCC(CN2CC3CCC2CN3Cc2cccc3c2C(=O)N(C2CCC(=O)NC2=O)C3)=C(c2ccc(Cl)cc2)C1 InChI=1S/C35H41ClN4O3/c1-35(2)15-14-23(29(16-35)22-6-8-26(36)9-7-22)17-38-20-28-11-10-27(38)21-39(28)18-24-4-3-5-25-19-40(34(43)32(24)25)30-12-13-31(41)37-33(30)42/h3-9,27-28,30H,10-21H2,1-2H3,(H,37,41,42) JANDKNHQJGUKTR-UHFFFAOYSA-N 531679 3-(7-((5-((4'-chloro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-yl)methyl)- 2,5-diazabicyclo[2.2.2]octan-2-yl)methyl)- 1-oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05462 Protein cereblon Homo sapiens 1900 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531679 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531679&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440742 463795140 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237156 O=C1CCC(N2Cc3cc(CN4CCN(Cc5ccccc5-c5ccc(Cl)cn5)CC4)ccc3C2=O)C(=O)N1 InChI=1S/C30H30ClN5O3/c31-23-6-8-26(32-16-23)24-4-2-1-3-21(24)18-35-13-11-34(12-14-35)17-20-5-7-25-22(15-20)19-36(30(25)39)27-9-10-28(37)33-29(27)38/h1-8,15-16,27H,9-14,17-19H2,(H,33,37,38) MKNRULNEEQYREC-UHFFFAOYSA-N 531680 3-(5-((4-(2-(5-chloropyridin-2- yl)benzyl)piperazin-1-yl)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05860 Protein cereblon Homo sapiens 560 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531680 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531680&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440724 463795141 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237157 Nc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12 InChI=1S/C13H11N3O4/c14-7-3-1-2-6-10(7)13(20)16(12(6)19)8-4-5-9(17)15-11(8)18/h1-3,8H,4-5,14H2,(H,15,17,18) UVSMNLNDYGZFPF-UHFFFAOYSA-N 65456 pomalidomide::US9694015, 6.2::19171-19-8::4-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione::Actimid::Pomalyst::CC-4047::US11059801, Compound D-4::US20230271966, Compound Pomalidomide::US20240365736, Ref 2::US20250129088, Compound pomalidomide::US20250313547, Example Control-1::US12441708, Example Control-1::US20260028326, Compound pomalidomide Protein cereblon Homo sapiens 1760 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=65456 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=65456&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134780 350083086 DB08910 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237158 CC1(C)CCC(CN2CCN(Cc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)CC2)=C(c2ccc(Cl)cc2)C1 InChI=1S/C33H39ClN4O3/c1-33(2)12-11-24(28(18-33)23-4-6-26(34)7-5-23)20-37-15-13-36(14-16-37)19-22-3-8-27-25(17-22)21-38(32(27)41)29-9-10-30(39)35-31(29)40/h3-8,17,29H,9-16,18-21H2,1-2H3,(H,35,39,40) WQWLFZCPJQODCS-UHFFFAOYSA-N 531682 3-(5-((4-((4'-chloro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2- yl)methyl)piperazin-1-yl)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-02785 Protein cereblon Homo sapiens 3070 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531682 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531682&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440362 463795143 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237159 CC1(C)CCC(CN2CCN(Cc3ccc4c(c3F)CN(C3CCC(=O)NC3=O)C4=O)CC2)=C(c2ccc(Cl)cc2)C1 InChI=1S/C33H38ClFN4O3/c1-33(2)12-11-22(26(17-33)21-3-6-24(34)7-4-21)18-37-13-15-38(16-14-37)19-23-5-8-25-27(30(23)35)20-39(32(25)42)28-9-10-29(40)36-31(28)41/h3-8,28H,9-20H2,1-2H3,(H,36,40,41) MZTYGVBASZLKIE-UHFFFAOYSA-N 531683 3-(5-((4-((4'-chloro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1-biphenyl]-2- yl)methyl)piperazin-1-yl)methyl)-4-fluoro- 1-oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-03468 Protein cereblon Homo sapiens 2960 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531683 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531683&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440100 463795144 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237160 CC1(C)CCC(CN2CCN(Cc3cc4c(cc3F)C(=O)N(C3CCC(=O)NC3=O)C4)CC2)=C(c2ccc(Cl)cc2)C1 InChI=1S/C33H38ClFN4O3/c1-33(2)10-9-22(27(17-33)21-3-5-25(34)6-4-21)18-37-11-13-38(14-12-37)19-24-15-23-20-39(32(42)26(23)16-28(24)35)29-7-8-30(40)36-31(29)41/h3-6,15-16,29H,7-14,17-20H2,1-2H3,(H,36,40,41) ATQOCQFQKUBIPF-UHFFFAOYSA-N 531684 3-(5-((4-((4'-chloro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2- yl)methyl)piperazin-1-yl)methyl)-6-fluoro- 1-oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-03578 Protein cereblon Homo sapiens 1830 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531684 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531684&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440094 463795145 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237161 O=C1CCC(N2Cc3ccc(CN4CCN(CC5=C(c6ccc(F)cc6)CCCC5)CC4)cc3C2=O)C(=O)N1 InChI=1S/C31H35FN4O3/c32-25-9-7-22(8-10-25)26-4-2-1-3-23(26)19-35-15-13-34(14-16-35)18-21-5-6-24-20-36(31(39)27(24)17-21)28-11-12-29(37)33-30(28)38/h5-10,17,28H,1-4,11-16,18-20H2,(H,33,37,38) REWGFCNBAARBJW-UHFFFAOYSA-N 531685 3-(6-((4-((4'-fluoro-3,4,5,6-tetrahydro- [1,1'-biphenyl]-2-yl)methyl)piperazin-1- yl)methyl)-1-oxoisoindolin-2-yl)piperidine- 2,6-dione::US20260028326, Compound GT-05465 Protein cereblon Homo sapiens 830 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531685 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531685&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440752 463795146 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237162 O=C1CCC(N2Cc3c(CN4CCN(CC5=C(c6ccc(F)cc6)CCCC5)CC4)cccc3C2=O)C(=O)N1 InChI=1S/C31H35FN4O3/c32-24-10-8-21(9-11-24)25-6-2-1-4-22(25)18-34-14-16-35(17-15-34)19-23-5-3-7-26-27(23)20-36(31(26)39)28-12-13-29(37)33-30(28)38/h3,5,7-11,28H,1-2,4,6,12-20H2,(H,33,37,38) MDQFOEZSQCKBTI-UHFFFAOYSA-N 531686 3-(4-((4-((4'-fluoro-3,4,5,6-tetrahydro- [1,1'-biphenyl]-2-yl)methyl)piperazin-1- yl)methyl)-1-oxoisoindolin-2-yl)piperidine- 2,6-dione::US20260028326, Compound GT-05861 Protein cereblon Homo sapiens 1290 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531686 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531686&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440853 463795147 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237163 CC1(C)CCC(CN2CC3CC(C2)N3Cc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)=C(c2ccc(Cl)cc2)C1 InChI=1S/C34H39ClN4O3/c1-34(2)12-11-23(29(15-34)22-4-6-25(35)7-5-22)17-37-19-26-14-27(20-37)38(26)16-21-3-8-28-24(13-21)18-39(33(28)42)30-9-10-31(40)36-32(30)41/h3-8,13,26-27,30H,9-12,14-20H2,1-2H3,(H,36,40,41) RBUBBUOUENNXQK-UHFFFAOYSA-N 531687 3-(5-((3-((4'-chloro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-yl)methyl)- 3,6-diazabicyclo[3.1.1]heptan-6- yl)methyl)-1-oxoisoindolin-2-yl)piperidine- 2,6-dione::US20260028326, Compound GT-03492 Protein cereblon Homo sapiens 520 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531687 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531687&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440749 463795148 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237164 O=C1CCC(N2Cc3c(ccc(CN4CCN(CC5=C(c6ccc(F)cc6)CCCC5)CC4)c3F)C2=O)C(=O)N1 InChI=1S/C31H34F2N4O3/c32-23-8-5-20(6-9-23)24-4-2-1-3-21(24)17-35-13-15-36(16-14-35)18-22-7-10-25-26(29(22)33)19-37(31(25)40)27-11-12-28(38)34-30(27)39/h5-10,27H,1-4,11-19H2,(H,34,38,39) ICRIFDACVUSGNS-UHFFFAOYSA-N 531688 3-(4-fluoro-5-((4-((4'-fluoro-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2- yl)methyl)piperazin-1-yl)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05466 Protein cereblon Homo sapiens 700 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531688 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531688&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440110 463795149 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237165 O=C1CCC(N2Cc3cc(C(=O)N4CCN(CC5=C(c6ccc(F)cc6)CCCC5)CC4)ccc3C2=O)C(=O)N1 InChI=1S/C31H33FN4O4/c32-24-8-5-20(6-9-24)25-4-2-1-3-22(25)18-34-13-15-35(16-14-34)30(39)21-7-10-26-23(17-21)19-36(31(26)40)27-11-12-28(37)33-29(27)38/h5-10,17,27H,1-4,11-16,18-19H2,(H,33,37,38) RLFDYXNYYZZYJF-UHFFFAOYSA-N 531690 3-(5-(4-((4'-fluoro-3,4,5,6-tetrahydro-[1,1'- biphenyl]-2-yl)methyl)piperazine-1- carbonyl)-1-oxoisoindolin-2-yl)piperidine- 2,6-dione::US20260028326, Compound GT-05863 Protein cereblon Homo sapiens 1020 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531690 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531690&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 142754134 463795150 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237166 CC1(C)CCC(CN2CC3CC(C2)N3Cc2ccc3c(c2F)CN(C2CCC(=O)NC2=O)C3=O)=C(c2ccc(Cl)cc2)C1 InChI=1S/C34H38ClFN4O3/c1-34(2)12-11-21(27(14-34)20-3-6-23(35)7-4-20)15-38-17-24-13-25(18-38)39(24)16-22-5-8-26-28(31(22)36)19-40(33(26)43)29-9-10-30(41)37-32(29)42/h3-8,24-25,29H,9-19H2,1-2H3,(H,37,41,42) LHYYJRGFICLULX-UHFFFAOYSA-N 531691 3-(5-((3-((4'-chloro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-yl)methyl)- 3,6-diazabicyclo[3.1.1]heptan-6- yl)methyl)-4-fluoro-1-oxoisoindolin-2- yl)piperidine-2,6-dione::US20260028326, Compound GT-03493 Protein cereblon Homo sapiens 750 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531691 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531691&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440656 463795151 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237167 O=C1CCC(N2Cc3cc(CC4CCN(C(=O)c5ccccc5-c5ccc(Cl)cc5)CC4)ccc3C2=O)C(=O)N1 InChI=1S/C32H30ClN3O4/c33-24-8-6-22(7-9-24)25-3-1-2-4-27(25)31(39)35-15-13-20(14-16-35)17-21-5-10-26-23(18-21)19-36(32(26)40)28-11-12-29(37)34-30(28)38/h1-10,18,20,28H,11-17,19H2,(H,34,37,38) WRQXAEWWJQCKGN-UHFFFAOYSA-N 531692 3-(5-((1-(4'-chloro-[1,1'-biphenyl]-2- carbonyl)piperidin-4-yl)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05467 Protein cereblon Homo sapiens 520 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531692 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531692&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440726 463795152 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237168 O=C1CCC(N2Cc3cc(CCCN4CCN(Cc5ccccc5-c5ccc(Cl)cc5)CC4)ccc3C2=O)C(=O)N1 InChI=1S/C33H35ClN4O3/c34-27-10-8-24(9-11-27)28-6-2-1-5-25(28)21-37-18-16-36(17-19-37)15-3-4-23-7-12-29-26(20-23)22-38(33(29)41)30-13-14-31(39)35-32(30)40/h1-2,5-12,20,30H,3-4,13-19,21-22H2,(H,35,39,40) RKHBQGNWTZMHMR-UHFFFAOYSA-N 531693 3-(5-(3-(4-((4'-chloro-[1,1'-biphenyl]-2- yl)methyl)piperazin-1-yl)propyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05893 Protein cereblon Homo sapiens 1150 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531693 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531693&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440359 463795153 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237169 CC1(C)CCC(CN2C3CC2CN(Cc2ccc4c(c2)CN(C2CCC(=O)NC2=O)C4=O)C3)=C(c2ccc(Cl)cc2)C1 InChI=1S/C34H39ClN4O3/c1-34(2)12-11-23(29(15-34)22-4-6-25(35)7-5-22)17-38-26-14-27(38)20-37(19-26)16-21-3-8-28-24(13-21)18-39(33(28)42)30-9-10-31(40)36-32(30)41/h3-8,13,26-27,30H,9-12,14-20H2,1-2H3,(H,36,40,41) FQXYTJKNHUFSMC-UHFFFAOYSA-N 531698 3-(5-((6-((4'-chloro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-yl)methyl)- 3,6-diazabicyclo[3.1.1]heptan-3- yl)methyl)-1-oxoisoindolin-2-yl)piperidine- 2,6-dione::US20260028326, Compound GT-03995 Protein cereblon Homo sapiens 630 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531698 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531698&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440690 463795154 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237170 O=C1CCC(N2C(=O)c3ccc(CN4CCN(C(=O)C5=C(c6ccc(F)cc6)CCCC5)CC4)cc3C2=O)C(=O)N1 InChI=1S/C31H31FN4O5/c32-21-8-6-20(7-9-21)22-3-1-2-4-23(22)29(39)35-15-13-34(14-16-35)18-19-5-10-24-25(17-19)31(41)36(30(24)40)26-11-12-27(37)33-28(26)38/h5-10,17,26H,1-4,11-16,18H2,(H,33,37,38) LQMYEFDLTQJTNF-UHFFFAOYSA-N 531700 2-(2,6-dioxopiperidin-3-yl)-5-((4-(4'- fluoro-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2- carbonyl)piperazin-1- yl)methyl)isoindoline-1,3-dione::US20260028326, Compound GT-05468 Protein cereblon Homo sapiens 1500 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531700 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531700&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440124 463795155 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237171 O=C1CCC(N2Cc3cc(CN4CCN(C(=O)c5ccccc5-c5ccc(Cl)cc5)CC4)ccc3C2=O)C(=O)N1 InChI=1S/C31H29ClN4O4/c32-23-8-6-21(7-9-23)24-3-1-2-4-26(24)30(39)35-15-13-34(14-16-35)18-20-5-10-25-22(17-20)19-36(31(25)40)27-11-12-28(37)33-29(27)38/h1-10,17,27H,11-16,18-19H2,(H,33,37,38) IAMMBPAUOQBCEL-UHFFFAOYSA-N 531703 3-(5-(4-((4-(4'-chloro-[1,1'-biphenyl]-2- carbonyl)piperazin-1-yl)methyl)phenyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05874 Protein cereblon Homo sapiens 440 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531703 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531703&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440105 463795156 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237172 CC1(C)CCC(CN2CC3CCC(C2)N3Cc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)=C(c2ccc(Cl)cc2)C1 InChI=1S/C35H41ClN4O3/c1-35(2)14-13-24(30(16-35)23-4-6-26(36)7-5-23)18-38-20-27-8-9-28(21-38)39(27)17-22-3-10-29-25(15-22)19-40(34(29)43)31-11-12-32(41)37-33(31)42/h3-7,10,15,27-28,31H,8-9,11-14,16-21H2,1-2H3,(H,37,41,42) ZLCPOMARMDEDSX-UHFFFAOYSA-N 531704 3-(5-((3-((4'-chloro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-yl)methyl)- 3,8-diazabicyclo[3.2.1]octan-8-yl)methyl)- 1-oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-03889 Protein cereblon Homo sapiens 710 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531704 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531704&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440382 463795157 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237173 O=C1CCC(N2Cc3ccc(CN4CCN(C(=O)C5=C(c6ccc(F)cc6)CCCC5)CC4)cc3C2=O)C(=O)N1 InChI=1S/C31H33FN4O4/c32-23-9-7-21(8-10-23)24-3-1-2-4-25(24)30(39)35-15-13-34(14-16-35)18-20-5-6-22-19-36(31(40)26(22)17-20)27-11-12-28(37)33-29(27)38/h5-10,17,27H,1-4,11-16,18-19H2,(H,33,37,38) JFOGJYVUHINDDT-UHFFFAOYSA-N 531705 3-(6-((4-(4'-fluoro-3,4,5,6-tetrahydro-[1,1'- biphenyl]-2-carbonyl)piperazin-1- yl)methyl)-1-oxoisoindolin-2-yl)piperidine- 2,6-dione::US20260028326, Compound GT-05470 Protein cereblon Homo sapiens 980 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531705 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531705&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440384 463795158 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237174 O=C(c1ccccc1-c1ccc(Cl)cc1)N1CCCCCC1 InChI=1S/C19H20ClNO/c20-16-11-9-15(10-12-16)17-7-3-4-8-18(17)19(22)21-13-5-1-2-6-14-21/h3-4,7-12H,1-2,5-6,13-14H2 GKBNWIQTTCRZBK-UHFFFAOYSA-N 531708 3-(5-(3-(4'-chloro-[1,1'-biphenyl]-2- carbonyl)-3,8-diazabicyclo[3.2.1]octan-8- yl)-1-oxoisoindolin-2-yl)piperidine-2,6- dione::US20260028326, Compound GT-05875 Protein cereblon Homo sapiens 510 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531708 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531708&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440523 463795159 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237175 CC1(C)CCC(CN2CC3CCC(C2)N3Cc2ccc3c(c2F)CN(C2CCC(=O)NC2=O)C3=O)=C(c2ccc(Cl)cc2)C1 InChI=1S/C35H40ClFN4O3/c1-35(2)14-13-22(28(15-35)21-3-6-24(36)7-4-21)16-39-18-25-8-9-26(19-39)40(25)17-23-5-10-27-29(32(23)37)20-41(34(27)44)30-11-12-31(42)38-33(30)43/h3-7,10,25-26,30H,8-9,11-20H2,1-2H3,(H,38,42,43) WEHHHCCUXIBRNB-UHFFFAOYSA-N 531709 3-(5-((3-((4'-chloro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-yl)methyl)- 3,8-diazabicyclo[3.2.1]octan-8-yl)methyl)- 4-fluoro-1-oxoisoindolin-2-yl)piperidine- 2,6-dione::US20260028326, Compound GT-03890 Protein cereblon Homo sapiens 510 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531709 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531709&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440758 463795160 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237176 O=C1CCC(N2Cc3c(CN4CCN(C(=O)C5=C(c6ccc(F)cc6)CCCC5)CC4)cccc3C2=O)C(=O)N1 InChI=1S/C31H33FN4O4/c32-22-10-8-20(9-11-22)23-5-1-2-6-24(23)30(39)35-16-14-34(15-17-35)18-21-4-3-7-25-26(21)19-36(31(25)40)27-12-13-28(37)33-29(27)38/h3-4,7-11,27H,1-2,5-6,12-19H2,(H,33,37,38) XLBGUSOVIQUSRL-UHFFFAOYSA-N 531710 3-(4-((4-(4'-fluoro-3,4,5,6-tetrahydro-[1,1'- biphenyl]-2-carbonyl)piperazin-1- yl)methyl)-1-oxoisoindolin-2-yl)piperidine- 2,6-dione::US20260028326, Compound GT-05471 Protein cereblon Homo sapiens 1080 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531710 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531710&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440233 463795161 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237177 O=C1CCC(N2Cc3c(CN4CCN(Cc5ccccc5-c5ccc(Cl)cc5)CC4)cccc3C2=O)C(=O)N1 InChI=1S/C31H31ClN4O3/c32-24-10-8-21(9-11-24)25-6-2-1-4-22(25)18-34-14-16-35(17-15-34)19-23-5-3-7-26-27(23)20-36(31(26)39)28-12-13-29(37)33-30(28)38/h1-11,28H,12-20H2,(H,33,37,38) TUAWVMVWEVAELN-UHFFFAOYSA-N 531713 3-(5-(2-(4-((4'-chloro-[1,1'-biphenyl]-2- yl)methyl)piperazin-1-yl)ethyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05876 Protein cereblon Homo sapiens 120 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531713 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531713&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440144 463795162 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237178 CC1(C)CCC(CN2C3CCC2CN(Cc2ccc4c(c2)CN(C2CCC(=O)NC2=O)C4=O)C3)=C(c2ccc(Cl)cc2)C1 InChI=1S/C35H41ClN4O3/c1-35(2)14-13-24(30(16-35)23-4-6-26(36)7-5-23)18-39-27-8-9-28(39)21-38(20-27)17-22-3-10-29-25(15-22)19-40(34(29)43)31-11-12-32(41)37-33(31)42/h3-7,10,15,27-28,31H,8-9,11-14,16-21H2,1-2H3,(H,37,41,42) OWWKJIWXUFALFK-UHFFFAOYSA-N 531714 3-(5-((8-((4'-chloro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-yl)methyl)- 3,8-diazabicyclo[3.2.1]octan-3-yl)methyl)- 1-oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-03996 Protein cereblon Homo sapiens 1440 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531714 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531714&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440505 463795163 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237179 O=C1CCC(N2Cc3c(ccc(CN4CCN(C(=O)C5=C(c6ccc(F)cc6)CCCC5)CC4)c3F)C2=O)C(=O)N1 InChI=1S/C31H32F2N4O4/c32-21-8-5-19(6-9-21)22-3-1-2-4-23(22)30(40)36-15-13-35(14-16-36)17-20-7-10-24-25(28(20)33)18-37(31(24)41)26-11-12-27(38)34-29(26)39/h5-10,26H,1-4,11-18H2,(H,34,38,39) CEODUWXBIDYAQC-UHFFFAOYSA-N 531715 3-(4-fluoro-5-((4-(4'-fluoro-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2- carbonyl)piperazin-1-yl)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05472 Protein cereblon Homo sapiens 1120 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531715 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531715&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440701 463795164 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237180 O=C1CCC(N2Cc3c(ccc(CN4CCN(Cc5ccccc5-c5ccc(F)cc5)CC4)c3F)C2=O)C(=O)N1 InChI=1S/C31H30F2N4O3/c32-23-8-5-20(6-9-23)24-4-2-1-3-21(24)17-35-13-15-36(16-14-35)18-22-7-10-25-26(29(22)33)19-37(31(25)40)27-11-12-28(38)34-30(27)39/h1-10,27H,11-19H2,(H,34,38,39) NTQNPPNXIJSZFQ-UHFFFAOYSA-N 531716 3-(4-fluoro-5-((4-((4'-fluoro-[1,1'- biphenyl]-2-yl)methyl)piperazin-1- yl)methyl)-1-oxoisoindolin-2-yl)piperidine- 2,6-dione::US20260028326, Compound GT-05602 Protein cereblon Homo sapiens 560 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531716 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531716&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440877 463795165 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237181 CC1(C)CCC(CN2C[C@H]3C[C@@H]2CN3Cc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)=C(c2ccc(Cl)cc2)C1 InChI=1S/C34H39ClN4O3/c1-34(2)12-11-23(29(15-34)22-4-6-25(35)7-5-22)17-38-20-26-14-27(38)19-37(26)16-21-3-8-28-24(13-21)18-39(33(28)42)30-9-10-31(40)36-32(30)41/h3-8,13,26-27,30H,9-12,14-20H2,1-2H3,(H,36,40,41) GKUJYDYWOSWJHZ-UHFFFAOYSA-N 531717 3-(5-(((1R,4R)-5-((4'-chloro-5,5-dimethyl- 3,4,5,6-tetrahydro-[1,1'-biphenyl]-2- yl)methyl)-2,5-diazabicyclo[2.2.1]heptan- 2-yl)methyl)-1-oxoisoindolin-2- yl)piperidine-2,6-dione::US20260028326, Compound GT-03887 Protein cereblon Homo sapiens 190 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531717 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531717&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440399 463795166 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237182 O=C1CCC(N2Cc3cc(CN4CCN(C(=O)C5=C(c6ccc(F)cc6)CCCC5)CC4)c(F)cc3C2=O)C(=O)N1 InChI=1S/C31H32F2N4O4/c32-22-7-5-19(6-8-22)23-3-1-2-4-24(23)30(40)36-13-11-35(12-14-36)17-21-15-20-18-37(31(41)25(20)16-26(21)33)27-9-10-28(38)34-29(27)39/h5-8,15-16,27H,1-4,9-14,17-18H2,(H,34,38,39) NQWMZZNKNQMNGX-UHFFFAOYSA-N 531718 3-(6-fluoro-5-((4-(4'-fluoro-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2- carbonyl)piperazin-1-yl)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05473 Protein cereblon Homo sapiens 1160 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531718 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531718&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440768 463795167 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237183 O=C1CCC(N2Cc3cc(CN4CCN(Cc5ccccc5-c5ccc(F)cc5)CC4)c(F)cc3C2=O)C(=O)N1 InChI=1S/C31H30F2N4O3/c32-24-7-5-20(6-8-24)25-4-2-1-3-21(25)17-35-11-13-36(14-12-35)18-23-15-22-19-37(31(40)26(22)16-27(23)33)28-9-10-29(38)34-30(28)39/h1-8,15-16,28H,9-14,17-19H2,(H,34,38,39) DNHJHOWXUDHILA-UHFFFAOYSA-N 531719 3-(6-fluoro-5-((4-((4'-fluoro-[1,1'- biphenyl]-2-yl)methyl)piperazin-1- yl)methyl)-1-oxoisoindolin-2-yl)piperidine- 2,6-dione::US20260028326, Compound GT-05603 Protein cereblon Homo sapiens 940 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531719 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531719&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440385 463795168 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237184 CC1(C)CCC(CN2C[C@H]3C[C@@H]2CN3Cc2ccc3c(c2F)CN(C2CCC(=O)NC2=O)C3=O)=C(c2ccc(Cl)cc2)C1 InChI=1S/C34H38ClFN4O3/c1-34(2)12-11-21(27(14-34)20-3-6-23(35)7-4-20)15-38-17-25-13-24(38)18-39(25)16-22-5-8-26-28(31(22)36)19-40(33(26)43)29-9-10-30(41)37-32(29)42/h3-8,24-25,29H,9-19H2,1-2H3,(H,37,41,42) DYJZKNOQHSVJHE-UHFFFAOYSA-N 531720 3-(5-(((1R,4R)-5-((4'-chloro-5,5-dimethyl- 3,4,5,6-tetrahydro-[1,1'biphenyl]-2- yl)methyl)-2,5-diazabicyclo[2.2.1]heptan- 2-yl)methyl)-4-fluoro-1-oxoisoindolin-2- yl)piperidine-2,6-dione::US20260028326, Compound GT-03888 Protein cereblon Homo sapiens 240 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531720 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531720&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 142754033 463795169 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237185 O=C1CCC(N2Cc3cc(CN4CCN(C(=O)C5=C(c6ccc(F)cc6)CCCC5)CC4)cc(F)c3C2=O)C(=O)N1 InChI=1S/C31H32F2N4O4/c32-22-7-5-20(6-8-22)23-3-1-2-4-24(23)30(40)36-13-11-35(12-14-36)17-19-15-21-18-37(31(41)28(21)25(33)16-19)26-9-10-27(38)34-29(26)39/h5-8,15-16,26H,1-4,9-14,17-18H2,(H,34,38,39) QOTCBWPXTPCMLR-UHFFFAOYSA-N 531721 3-(7-fluoro-5-((4-(4'-fluoro-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2- carbonyl)piperazin-1-yl)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05474 Protein cereblon Homo sapiens 1170 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531721 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531721&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 142322171 463795170 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237186 O=C1CCC(N2Cc3cc(CN4CCN(Cc5ccccc5-c5ccc(F)cc5)CC4)cc(F)c3C2=O)C(=O)N1 InChI=1S/C31H30F2N4O3/c32-24-7-5-21(6-8-24)25-4-2-1-3-22(25)18-36-13-11-35(12-14-36)17-20-15-23-19-37(31(40)29(23)26(33)16-20)27-9-10-28(38)34-30(27)39/h1-8,15-16,27H,9-14,17-19H2,(H,34,38,39) UEXYVDADZIQNGJ-UHFFFAOYSA-N 531722 3-(7-fluoro-5-((4-((4'-fluoro-[1,1'- biphenyl]-2-yl)methyl)piperazin-1- yl)methyl)-1-oxoisoindolin-2-yl)piperidine- 2,6-dione::US20260028326, Compound GT-05604 Protein cereblon Homo sapiens 720 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531722 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531722&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 142322189 463795171 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237187 CC1(C)CCC(CN2C[C@@H]3C[C@H]2CN3Cc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)=C(c2ccc(Cl)cc2)C1 InChI=1S/C34H39ClN4O3/c1-34(2)12-11-23(29(15-34)22-4-6-25(35)7-5-22)17-38-20-26-14-27(38)19-37(26)16-21-3-8-28-24(13-21)18-39(33(28)42)30-9-10-31(40)36-32(30)41/h3-8,13,26-27,30H,9-12,14-20H2,1-2H3,(H,36,40,41) GKUJYDYWOSWJHZ-UHFFFAOYSA-N 531724 3-(5-(((1S,4S)-5-((4'-chloro-5,5-dimethyl- 3,4,5,6-tetrahydro-[1,1'-biphenyl]-2- yl)methyl)-2,5-diazabicyclo[2.2.1]heptan- 2-yl)methyl)-1-oxoisoindolin-2- yl)piperidine-2,6-dione::US20260028326, Compound GT-03997 Protein cereblon Homo sapiens 770 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531724 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531724&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440367 463795172 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237188 O=C1CCC(N2Cc3c(ccc(CN4C5CC4CN(C(=O)C4=C(c6ccc(F)cc6)CCCC4)C5)c3F)C2=O)C(=O)N1 InChI=1S/C32H32F2N4O4/c33-20-8-5-18(6-9-20)23-3-1-2-4-24(23)31(41)36-15-21-13-22(16-36)37(21)14-19-7-10-25-26(29(19)34)17-38(32(25)42)27-11-12-28(39)35-30(27)40/h5-10,21-22,27H,1-4,11-17H2,(H,35,39,40) AQAOTGRXNXNOBH-UHFFFAOYSA-N 531725 3-(4-fluoro-5-((3-(4'-fluoro-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-carbonyl)-3,6- diazabicyclo[3.1.1]heptan-6-yl)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05475 Protein cereblon Homo sapiens 910 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531725 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531725&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440141 463795173 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237189 O=C1CCC(N2Cc3c(CN4CCN(Cc5ccccc5-c5ccc(F)cc5)CC4)cccc3C2=O)C(=O)N1 InChI=1S/C31H31FN4O3/c32-24-10-8-21(9-11-24)25-6-2-1-4-22(25)18-34-14-16-35(17-15-34)19-23-5-3-7-26-27(23)20-36(31(26)39)28-12-13-29(37)33-30(28)38/h1-11,28H,12-20H2,(H,33,37,38) KXOUEURMQOUBQR-UHFFFAOYSA-N 531728 3-(4-((4-((4'-fluoro-[1,1'-biphenyl]-2- yl)methyl)piperazin-1-yl)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05605 Protein cereblon Homo sapiens 1050 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531728 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531728&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 142754088 463795174 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237190 CC1(C)CCC(CN2CCC(Cc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)CC2)=C(c2ccc(Cl)cc2)C1 InChI=1S/C34H40ClN3O3/c1-34(2)14-11-25(29(19-34)24-4-6-27(35)7-5-24)20-37-15-12-22(13-16-37)17-23-3-8-28-26(18-23)21-38(33(28)41)30-9-10-31(39)36-32(30)40/h3-8,18,22,30H,9-17,19-21H2,1-2H3,(H,36,39,40) XXNBFXAUAVJUPI-UHFFFAOYSA-N 531729 3-(5-((1-((4'-chloro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2- yl)methyl)piperidin-4-yl)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-03368 Protein cereblon Homo sapiens 1380 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531729 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531729&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440875 463795175 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237191 O=C1CCC(N2Cc3cc(CN4C5CC4CN(C(=O)C4=C(c6ccc(F)cc6)CCCC4)C5)c(F)cc3C2=O)C(=O)N1 InChI=1S/C32H32F2N4O4/c33-21-7-5-18(6-8-21)24-3-1-2-4-25(24)31(41)36-16-22-12-23(17-36)37(22)15-20-11-19-14-38(32(42)26(19)13-27(20)34)28-9-10-29(39)35-30(28)40/h5-8,11,13,22-23,28H,1-4,9-10,12,14-17H2,(H,35,39,40) NSHSGCXVLVZOOX-UHFFFAOYSA-N 531730 3-(6-fluoro-5-((3-(4'-fluoro-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-carbonyl)-3,6- diazabicyclo[3.1.1]heptan-6-yl)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05476 Protein cereblon Homo sapiens 1200 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531730 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531730&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440519 463795176 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237192 O=C1CCC(N2Cc3ccc(CN4CCN(Cc5ccccc5-c5ccc(F)cc5)CC4)cc3C2=O)C(=O)N1 InChI=1S/C31H31FN4O3/c32-25-9-7-22(8-10-25)26-4-2-1-3-23(26)19-35-15-13-34(14-16-35)18-21-5-6-24-20-36(31(39)27(24)17-21)28-11-12-29(37)33-30(28)38/h1-10,17,28H,11-16,18-20H2,(H,33,37,38) IHOCNCIXDAAWKL-UHFFFAOYSA-N 531731 3-(6-((4-((4'-fluoro-[1,1'-biphenyl]-2- yl)methyl)piperazin-1-yl)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05606 Protein cereblon Homo sapiens 1180 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531731 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531731&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440548 463795177 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237193 CC1(C)CCC(CN2CCN(Cc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)CC2)=C(c2ccc(F)cc2)C1 InChI=1S/C33H39FN4O3/c1-33(2)12-11-24(28(18-33)23-4-6-26(34)7-5-23)20-37-15-13-36(14-16-37)19-22-3-8-27-25(17-22)21-38(32(27)41)29-9-10-30(39)35-31(29)40/h3-8,17,29H,9-16,18-21H2,1-2H3,(H,35,39,40) KQUYVUPAZUHLKI-UHFFFAOYSA-N 531732 3-(5-((4-((4'-fluoro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2- yl)methyl)piperazin-1-yl)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-03454 Protein cereblon Homo sapiens 410 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531732 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531732&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 142754098 463795178 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237194 O=C1CCC(N2Cc3cc(CN4C5CC4CN(C(=O)C4=C(c6ccc(F)cc6)CCCC4)C5)cc(F)c3C2=O)C(=O)N1 InChI=1S/C32H32F2N4O4/c33-21-7-5-19(6-8-21)24-3-1-2-4-25(24)31(41)36-16-22-13-23(17-36)37(22)14-18-11-20-15-38(32(42)29(20)26(34)12-18)27-9-10-28(39)35-30(27)40/h5-8,11-12,22-23,27H,1-4,9-10,13-17H2,(H,35,39,40) UTSOLZRLRVFTMG-UHFFFAOYSA-N 531733 3-(7-fluoro-5-((3-(4'-fluoro-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-carbonyll)-3,6- diazabicyclo[3.1.1]heptan-6-yl)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05477 Protein cereblon Homo sapiens 660 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531733 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531733&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440739 463795179 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237195 O=C1CCC(N2Cc3cc(CN4C5CC4CN(Cc4ccccc4-c4ccc(Cl)cc4)C5)ccc3C2=O)C(=O)N1 InChI=1S/C32H31ClN4O3/c33-24-8-6-21(7-9-24)27-4-2-1-3-22(27)16-35-18-25-14-26(19-35)36(25)15-20-5-10-28-23(13-20)17-37(32(28)40)29-11-12-30(38)34-31(29)39/h1-10,13,25-26,29H,11-12,14-19H2,(H,34,38,39) YLSGVEJSRICMNU-UHFFFAOYSA-N 531734 3-(5-((3-((4'-chloro-[1,1'-biphenyl]-2- yl)methyl)-3,6-diazabicyclo[3.1.1]heptan- 6-yl)methyl)-1-oxoisoindolin-2- yl)piperidine-2,6-dione::US20260028326, Compound GT-05607 Protein cereblon Homo sapiens 1150 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531734 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531734&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 142754111 463795180 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237196 CC1(C)CCC(CN2CCC(Cc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)CC2)=C(c2ccc(F)cc2)C1 InChI=1S/C34H40FN3O3/c1-34(2)14-11-25(29(19-34)24-4-6-27(35)7-5-24)20-37-15-12-22(13-16-37)17-23-3-8-28-26(18-23)21-38(33(28)41)30-9-10-31(39)36-32(30)40/h3-8,18,22,30H,9-17,19-21H2,1-2H3,(H,36,39,40) XKMBTYAKBJAUQE-UHFFFAOYSA-N 531735 3-(5-((1-((4'-fluoro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2- yl)methyl)piperidin-4-yl)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-03455 Protein cereblon Homo sapiens 340 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531735 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531735&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440239 463795181 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237197 O=C1CCC(N2Cc3c(CN4C5CC4CN(C(=O)C4=C(c6ccc(F)cc6)CCCC4)C5)cccc3C2=O)C(=O)N1 InChI=1S/C32H33FN4O4/c33-21-10-8-19(9-11-21)24-5-1-2-6-25(24)31(40)35-16-22-14-23(17-35)36(22)15-20-4-3-7-26-27(20)18-37(32(26)41)28-12-13-29(38)34-30(28)39/h3-4,7-11,22-23,28H,1-2,5-6,12-18H2,(H,34,38,39) GUOYBYJVSJBIHD-UHFFFAOYSA-N 531736 3-(4-((3-(4'-fluoro-3,4,5,6-tetrahydro-[1,1'- biphenyl]-2-carbonyl)-3,6- diazabicyclo[3.1.1]heptan-6-yl)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05478 Protein cereblon Homo sapiens 1120 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531736 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531736&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440366 463795182 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237198 O=C1CCC(N2Cc3c(ccc(CN4C5CC4CN(Cc4ccccc4-c4ccc(Cl)cc4)C5)c3F)C2=O)C(=O)N1 InChI=1S/C32H30ClFN4O3/c33-22-8-5-19(6-9-22)25-4-2-1-3-20(25)14-36-16-23-13-24(17-36)37(23)15-21-7-10-26-27(30(21)34)18-38(32(26)41)28-11-12-29(39)35-31(28)40/h1-10,23-24,28H,11-18H2,(H,35,39,40) LZXRPUCAVKWXTF-UHFFFAOYSA-N 531739 3-(5-((3-((4'-chloro-[1,1'-biphenyl]-2- yl)methyl)-3,6-diazabicyclo[3.1.1]heptan- 6-yl)methyl)-4-fluoro-1-oxoisoindolin-2- yl)piperidine-2,6-dione::US20260028326, Compound GT-05608 Protein cereblon Homo sapiens 800 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531739 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531739&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440706 463795183 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237199 O=C1CCC(N2Cc3cc(CN4CCN(Cc5ccccc5-c5ccc(Cl)cc5)CC4)ccc3C2=O)C(=O)N1 InChI=1S/C31H31ClN4O3/c32-25-8-6-22(7-9-25)26-4-2-1-3-23(26)19-35-15-13-34(14-16-35)18-21-5-10-27-24(17-21)20-36(31(27)39)28-11-12-29(37)33-30(28)38/h1-10,17,28H,11-16,18-20H2,(H,33,37,38) IDBBGINXUGUDPF-UHFFFAOYSA-N 531740 3-(5-((4-((4'-chloro-[1,1'-biphenyl]-2- yl)methyl)piperazin-1-yl)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-03355 Protein cereblon Homo sapiens 770 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531740 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531740&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440872 463795184 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237200 O=C1CCC(N2Cc3ccc(CN4C5CC4CN(C(=O)C4=C(c6ccc(F)cc6)CCCC4)C5)cc3C2=O)C(=O)N1 InChI=1S/C32H33FN4O4/c33-22-9-7-20(8-10-22)25-3-1-2-4-26(25)31(40)35-17-23-14-24(18-35)36(23)15-19-5-6-21-16-37(32(41)27(21)13-19)28-11-12-29(38)34-30(28)39/h5-10,13,23-24,28H,1-4,11-12,14-18H2,(H,34,38,39) MGHAPDWFPJUNSH-UHFFFAOYSA-N 531741 3-(6-((3-(4'-fluoro-3,4,5,6-tetrahydro-[1,1'- biphenyl]-2-carbonyl)-3,6- diazabicyclo[3.1.1]heptan-6-yl)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05479 Protein cereblon Homo sapiens 720 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531741 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531741&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134439832 463795185 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237201 O=C1CCC(N2Cc3cc(CN4C5CC4CN(Cc4ccccc4-c4ccc(Cl)cc4)C5)c(F)cc3C2=O)C(=O)N1 InChI=1S/C32H30ClFN4O3/c33-23-7-5-19(6-8-23)26-4-2-1-3-20(26)14-36-17-24-12-25(18-36)37(24)16-22-11-21-15-38(32(41)27(21)13-28(22)34)29-9-10-30(39)35-31(29)40/h1-8,11,13,24-25,29H,9-10,12,14-18H2,(H,35,39,40) XSAHTBYMZOBUEH-UHFFFAOYSA-N 531744 3-(5-((3-((4'-chloro-[1,1'-biphenyl]-2- yl)methyl)-3,6-diazabicyclo[3.1.1]heptan- 6-yl)methyl)-6-fluoro-1-oxoisoindolin-2- yl)piperidine-2,6-dione::US20260028326, Compound GT-05609 Protein cereblon Homo sapiens 540 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531744 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531744&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440777 463795186 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237202 O=C1CCC(N2Cc3c(ccc(CN4CCN(Cc5ccccc5-c5ccc(Cl)cc5)CC4)c3F)C2=O)C(=O)N1 InChI=1S/C31H30ClFN4O3/c32-23-8-5-20(6-9-23)24-4-2-1-3-21(24)17-35-13-15-36(16-14-35)18-22-7-10-25-26(29(22)33)19-37(31(25)40)27-11-12-28(38)34-30(27)39/h1-10,27H,11-19H2,(H,34,38,39) ISPFXSUJVHDAGW-UHFFFAOYSA-N 531745 3-(5-((4-((4'-chloro-[1,1'-biphenyl]-2- yl)methyl)piperazin-1-yl)methyl)-4-fluoro- 1-oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-03694 Protein cereblon Homo sapiens 540 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531745 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531745&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440546 463795187 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237203 O=C1CCC(N2Cc3cccc(CN4C5CC4CN(C(=O)C4=C(c6ccc(F)cc6)CCCC4)C5)c3C2=O)C(=O)N1 InChI=1S/C32H33FN4O4/c33-22-10-8-19(9-11-22)25-6-1-2-7-26(25)31(40)35-17-23-14-24(18-35)36(23)15-20-4-3-5-21-16-37(32(41)29(20)21)27-12-13-28(38)34-30(27)39/h3-5,8-11,23-24,27H,1-2,6-7,12-18H2,(H,34,38,39) GRGWMGDVAABIJW-UHFFFAOYSA-N 531746 3-(7-((3-(4'-fluoro-3,4,5,6-tetrahydro-[1,1'- biphenyl]-2-carbonyl)-3,6- diazabicyclo[3.1.1]heptan-6-yl)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05480 Protein cereblon Homo sapiens 1740 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531746 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531746&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440380 463795188 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237204 O=C1CCC(N2Cc3cc(CN4C5CC4CN(Cc4ccccc4-c4ccc(Cl)cc4)C5)cc(F)c3C2=O)C(=O)N1 InChI=1S/C32H30ClFN4O3/c33-23-7-5-20(6-8-23)26-4-2-1-3-21(26)15-36-17-24-13-25(18-36)37(24)14-19-11-22-16-38(32(41)30(22)27(34)12-19)28-9-10-29(39)35-31(28)40/h1-8,11-12,24-25,28H,9-10,13-18H2,(H,35,39,40) NOXQRRWOORZDCH-UHFFFAOYSA-N 531747 3-(5-((3-((4'-chloro-[1,1'-biphenyl]-2- yl)methyl)-3,6-diazabicyclo[3.1.1]heptan- 6-yl)methyl)-7-fluoro-1-oxoisoindolin-2- yl)piperidine-2,6-dione::US20260028326, Compound GT-05610 Protein cereblon Homo sapiens 640 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531747 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531747&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440883 463795189 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237205 O=C1CCC(N2Cc3cc(CN4CCN(Cc5ccccc5-c5ccc(Cl)cc5)CC4)c(F)cc3C2=O)C(=O)N1 InChI=1S/C31H30ClFN4O3/c32-24-7-5-20(6-8-24)25-4-2-1-3-21(25)17-35-11-13-36(14-12-35)18-23-15-22-19-37(31(40)26(22)16-27(23)33)28-9-10-29(38)34-30(28)39/h1-8,15-16,28H,9-14,17-19H2,(H,34,38,39) CQKQJDDJPNSVKF-UHFFFAOYSA-N 531748 3-(5-((4-((4'-chloro-[1,1'-biphenyl]-2- yl)methyl)piperazin-1-yl)methyl)-6-fluoro- 1-oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-03695 Protein cereblon Homo sapiens 1170 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531748 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531748&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440753 463795190 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237206 O=C1CCC(N2Cc3cc(C=C4CN(C(=O)c5ccccc5-c5ccc(Cl)cc5)C4)ccc3C2=O)C(=O)N1 InChI=1S/C30H24ClN3O4/c31-22-8-6-20(7-9-22)23-3-1-2-4-25(23)29(37)33-15-19(16-33)13-18-5-10-24-21(14-18)17-34(30(24)38)26-11-12-27(35)32-28(26)36/h1-10,13-14,26H,11-12,15-17H2,(H,32,35,36) SAPBQRYEJIEWJV-UHFFFAOYSA-N 531749 3-(5-((1-(4'-chloro-[1,1'-biphenyl]-2- carbonyl)azetidin-3-ylidene)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05482 Protein cereblon Homo sapiens 330 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531749 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531749&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440555 463795191 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237207 O=C1CCC(N2Cc3cc(CN4CCCN(Cc5ccccc5-c5ccc(Cl)cc5)CC4)ccc3C2=O)C(=O)N1 InChI=1S/C32H33ClN4O3/c33-26-9-7-23(8-10-26)27-5-2-1-4-24(27)20-36-15-3-14-35(16-17-36)19-22-6-11-28-25(18-22)21-37(32(28)40)29-12-13-30(38)34-31(29)39/h1-2,4-11,18,29H,3,12-17,19-21H2,(H,34,38,39) GXDDMXLOQFEHAA-UHFFFAOYSA-N 531750 3-(5-((4-((4'-chloro-[1,1'-biphenyl]-2- yl)methyl)-1,4-diazepan-1-yl)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05611 Protein cereblon Homo sapiens 630 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531750 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531750&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440407 463795192 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237208 O=C1CCC(N2Cc3cc(CN4CCN(Cc5ccccc5-c5ccc(Cl)cc5)CC4)cc(F)c3C2=O)C(=O)N1 InChI=1S/C31H30ClFN4O3/c32-24-7-5-21(6-8-24)25-4-2-1-3-22(25)18-36-13-11-35(12-14-36)17-20-15-23-19-37(31(40)29(23)26(33)16-20)27-9-10-28(38)34-30(27)39/h1-8,15-16,27H,9-14,17-19H2,(H,34,38,39) UHOINYSOVDRHEG-UHFFFAOYSA-N 531751 3-(5-((4-((4'-chloro-[1,1'-biphenyl]-2- yl)methyl)piperazin-1-yl)methyl)-7-fluoro- 1-oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-03696 Protein cereblon Homo sapiens 880 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531751 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531751&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440430 463795193 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237209 CC1(C)CCC(CN2CC(=Cc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)C2)=C(c2ccc(F)cc2)C1 InChI=1S/C32H34FN3O3/c1-32(2)12-11-23(27(15-32)22-4-6-25(33)7-5-22)18-35-16-21(17-35)13-20-3-8-26-24(14-20)19-36(31(26)39)28-9-10-29(37)34-30(28)38/h3-8,13-14,28H,9-12,15-19H2,1-2H3,(H,34,37,38) CKDJIEYVLKEUAK-UHFFFAOYSA-N 531752 3-(5-((1-((4'-fluoro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2- yl)methyl)azetidin-3-ylidene)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05483 Protein cereblon Homo sapiens 510 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531752 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531752&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440551 463795194 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237210 O=C1CCC(N2Cc3cc(CN4CC5(CCN(Cc6ccccc6-c6ccc(Cl)cc6)CC5)C4)ccc3C2=O)C(=O)N1 InChI=1S/C34H35ClN4O3/c35-27-8-6-24(7-9-27)28-4-2-1-3-25(28)19-37-15-13-34(14-16-37)21-38(22-34)18-23-5-10-29-26(17-23)20-39(33(29)42)30-11-12-31(40)36-32(30)41/h1-10,17,30H,11-16,18-22H2,(H,36,40,41) XGUGBOUTGMPNRE-UHFFFAOYSA-N 531753 3-(5-((7-((4'-chloro-[1,1'-biphenyl]-2- yl)methyl)-2,7-diazaspiro[3.5]nonan-2- yl)methyl)-1-oxoisoindolin-2-yl)piperidine- 2,6-dione::US20260028326, Compound GT-05612 Protein cereblon Homo sapiens 650 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531753 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531753&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 142754135 463795195 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237211 O=C1CCC(N2Cc3cc(CN4CCN(C(=O)c5ccccc5-c5ccc(Cl)cc5)CC4)ccc3C2=O)C(=O)N1 InChI=1S/C31H29ClN4O4/c32-23-8-6-21(7-9-23)24-3-1-2-4-26(24)30(39)35-15-13-34(14-16-35)18-20-5-10-25-22(17-20)19-36(31(25)40)27-11-12-28(37)33-29(27)38/h1-10,17,27H,11-16,18-19H2,(H,33,37,38) IAMMBPAUOQBCEL-UHFFFAOYSA-N 531754 3-(5-((4-(4'-chloro-[1,1'-biphenyl]-2- carbonyl)piperazin-1-yl)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-03891 Protein cereblon Homo sapiens 230 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531754 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531754&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 142754154 463795196 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237212 O=C1CCC(N2Cc3cc(C(O)C4(O)CN(C(=O)c5ccccc5-c5ccc(Cl)cc5)C4)ccc3C2=O)C(=O)N1 InChI=1S/C30H26ClN3O6/c31-20-8-5-17(6-9-20)21-3-1-2-4-23(21)28(38)33-15-30(40,16-33)26(36)18-7-10-22-19(13-18)14-34(29(22)39)24-11-12-25(35)32-27(24)37/h1-10,13,24,26,36,40H,11-12,14-16H2,(H,32,35,37) BDSPIZIHSIYTEH-UHFFFAOYSA-N 531755 3-(5-((1-(4'-chloro-[1,1'-biphenyl]-2- carbonyl)-3-hydroxyazetidin-3- yl)(hydroxy)methyl)-1-oxoisoindolin-2- yl)piperidine-2,6-dione::US20260028326, Compound GT-05484 Protein cereblon Homo sapiens 360 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531755 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531755&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440169 463795197 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237213 O=C1CCC(N2Cc3cc(CN4CC5CN(Cc6ccccc6-c6ccc(Cl)cc6)CC5C4)ccc3C2=O)C(=O)N1 InChI=1S/C33H33ClN4O3/c34-27-8-6-22(7-9-27)28-4-2-1-3-23(28)15-37-18-25-16-36(17-26(25)19-37)14-21-5-10-29-24(13-21)20-38(33(29)41)30-11-12-31(39)35-32(30)40/h1-10,13,25-26,30H,11-12,14-20H2,(H,35,39,40) BHDNZBWUYFQNLX-UHFFFAOYSA-N 531756 3-(5-((5-((4'-chloro-[1,1'-biphenyl]-2- yl)methyl)hexahydropyrrolo[3,4-c]pyrrol- 2(1H)-yl)methyl)-1-oxoisoindolin-2- yl)piperidine-2,6-dione::US20260028326, Compound GT-05613 Protein cereblon Homo sapiens 590 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531756 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531756&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440886 463795198 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237214 O=C1CCC(N2Cc3cc(CN4C5CC4CN(Cc4ccccc4-c4ccc(Cl)cc4)C5)ccc3C2=O)C(=O)N1 InChI=1S/C32H31ClN4O3/c33-24-8-6-21(7-9-24)27-4-2-1-3-22(27)16-35-18-25-14-26(19-35)36(25)15-20-5-10-28-23(13-20)17-37(32(28)40)29-11-12-30(38)34-31(29)39/h1-10,13,25-26,29H,11-12,14-19H2,(H,34,38,39) YLSGVEJSRICMNU-UHFFFAOYSA-N 531734 3-(5-((3-((4'-chloro-[1,1'-biphenyl]-2- yl)methyl)-3,6-diazabicyclo[3.1.1]heptan- 6-yl)methyl)-1-oxoisoindolin-2- yl)piperidine-2,6-dione::US20260028326, Compound GT-05607 Protein cereblon Homo sapiens 880 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531734 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531734&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 142754111 463795180 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237215 CC1(C)CCC(CN2CC3CCC2CN3Cc2ccc3c(c2)C(=O)N(C2CCC(=O)NC2=O)C3)=C(c2ccc(Cl)cc2)C1 InChI=1S/C35H41ClN4O3/c1-35(2)14-13-25(30(16-35)23-5-7-26(36)8-6-23)18-39-21-27-9-10-28(39)20-38(27)17-22-3-4-24-19-40(34(43)29(24)15-22)31-11-12-32(41)37-33(31)42/h3-8,15,27-28,31H,9-14,16-21H2,1-2H3,(H,37,41,42) VOGDXWCGSIQIAT-UHFFFAOYSA-N 531757 3-(6-((5-((4'-chloro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-yl)methyl)- 2,5-diazabicyclo[2.2.2]octan-2-yl)methyl)- 1-oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05485 Protein cereblon Homo sapiens 740 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531757 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531757&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440155 463795199 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237216 CC1(C)CCC(CN2CCN(C(=O)c3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)CC2)=C(c2ccc(F)cc2)C1 InChI=1S/C33H37FN4O4/c1-33(2)12-11-23(27(18-33)21-3-6-25(34)7-4-21)19-36-13-15-37(16-14-36)31(41)22-5-8-26-24(17-22)20-38(32(26)42)28-9-10-29(39)35-30(28)40/h3-8,17,28H,9-16,18-20H2,1-2H3,(H,35,39,40) ZYTOIKXYRXYBEE-UHFFFAOYSA-N 531758 3-(5-(4-((4'-fluoro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2- yl)methyl)piperazine-1-carbonyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05614 Protein cereblon Homo sapiens 1410 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531758 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531758&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 142754156 463795200 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237217 O=C1CCC(N2Cc3cc(CC4CCN(Cc5ccccc5-c5ccc(Cl)cc5)CC4)ccc3C2=O)C(=O)N1 InChI=1S/C32H32ClN3O3/c33-26-8-6-23(7-9-26)27-4-2-1-3-24(27)19-35-15-13-21(14-16-35)17-22-5-10-28-25(18-22)20-36(32(28)39)29-11-12-30(37)34-31(29)38/h1-10,18,21,29H,11-17,19-20H2,(H,34,37,38) TTXMNKPIOQTAJE-UHFFFAOYSA-N 531759 3-(5-((1-((4'-chloro-[1,1'-biphenyl]-2- yl)methyl)piperidin-4-yl)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-03361 Protein cereblon Homo sapiens 1590 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531759 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531759&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440537 463795201 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237218 O=C1CCC(N2Cc3c(C(=O)N4CCN(Cc5ccccc5-c5ccc(Cl)cc5)CC4)cccc3C2=O)C(=O)N1 InChI=1S/C31H29ClN4O4/c32-22-10-8-20(9-11-22)23-5-2-1-4-21(23)18-34-14-16-35(17-15-34)30(39)24-6-3-7-25-26(24)19-36(31(25)40)27-12-13-28(37)33-29(27)38/h1-11,27H,12-19H2,(H,33,37,38) NNTDCCGVNGGPHE-UHFFFAOYSA-N 531760 3-(4-(4-((4'-chloro-[1,1'-biphenyl]-2- yl)methyl)piperazine-1-carbonyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05486 Protein cereblon Homo sapiens 1560 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531760 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531760&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440539 463795202 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237219 O=C1CCC(N2Cc3cc(C(=O)N4CCCN(Cc5ccccc5-c5ccc(Cl)cc5)CC4)ccc3C2=O)C(=O)N1 InChI=1S/C32H31ClN4O4/c33-25-9-6-21(7-10-25)26-5-2-1-4-23(26)19-35-14-3-15-36(17-16-35)31(40)22-8-11-27-24(18-22)20-37(32(27)41)28-12-13-29(38)34-30(28)39/h1-2,4-11,18,28H,3,12-17,19-20H2,(H,34,38,39) FHPGNZUQYLWTBF-UHFFFAOYSA-N 531761 3-(5-(4-((4'-chloro-[1,1'-biphenyl]-2- yl)methyl)-1,4-diazepane-1-carbonyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05616 Protein cereblon Homo sapiens 900 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531761 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531761&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440870 463795203 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237220 O=C1CCC(N2Cc3cc(CN4CCC(Nc5ccccc5-c5ccc(Cl)cc5)CC4)ccc3C2=O)C(=O)N1 InChI=1S/C31H31ClN4O3/c32-23-8-6-21(7-9-23)25-3-1-2-4-27(25)33-24-13-15-35(16-14-24)18-20-5-10-26-22(17-20)19-36(31(26)39)28-11-12-29(37)34-30(28)38/h1-10,17,24,28,33H,11-16,18-19H2,(H,34,37,38) BSTIESNZNHVAEH-UHFFFAOYSA-N 531762 3-(5-((4-((4'-chloro-[1,1'-biphenyl]-2- yl)amino)piperidin-1-yl)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-03991 Protein cereblon Homo sapiens 470 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531762 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531762&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440222 463795204 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237221 CC1(C)CCC(C(=O)N2CCC(Cc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)CC2)=C(c2ccc(F)cc2)C1 InChI=1S/C34H38FN3O4/c1-34(2)14-11-27(28(19-34)23-4-6-25(35)7-5-23)32(41)37-15-12-21(13-16-37)17-22-3-8-26-24(18-22)20-38(33(26)42)29-9-10-30(39)36-31(29)40/h3-8,18,21,29H,9-17,19-20H2,1-2H3,(H,36,39,40) FHNZLHRJUAZKAN-UHFFFAOYSA-N 531763 3-(5-((1-(4'-fluoro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2- carbonyl)piperidin-4-yl)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05487 Protein cereblon Homo sapiens 650 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531763 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531763&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440779 463795205 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237222 O=C1CCC(N2Cc3cc(C(=O)N4CC5(CCN(Cc6ccccc6-c6ccc(Cl)cc6)CC5)C4)ccc3C2=O)C(=O)N1 InChI=1S/C34H33ClN4O4/c35-26-8-5-22(6-9-26)27-4-2-1-3-24(27)18-37-15-13-34(14-16-37)20-38(21-34)32(42)23-7-10-28-25(17-23)19-39(33(28)43)29-11-12-30(40)36-31(29)41/h1-10,17,29H,11-16,18-21H2,(H,36,40,41) VATLYICYYIKCME-UHFFFAOYSA-N 531764 3-(5-(7-((4'-chloro-[1,1'-biphenyl]-2- yl)methyl)-2,7-diazaspiro[3.5]nonane-2- carbonyl)-1-oxoisoindolin-2-yl)piperidine- 2,6-dione::US20260028326, Compound GT-05641 Protein cereblon Homo sapiens 1480 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531764 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531764&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440835 463795206 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237223 O=C1CCC(N2Cc3cc(NC4CCN(Cc5ccccc5-c5ccc(Cl)cc5)CC4)ccc3C2=O)C(=O)N1 InChI=1S/C31H31ClN4O3/c32-23-7-5-20(6-8-23)26-4-2-1-3-21(26)18-35-15-13-24(14-16-35)33-25-9-10-27-22(17-25)19-36(31(27)39)28-11-12-29(37)34-30(28)38/h1-10,17,24,28,33H,11-16,18-19H2,(H,34,37,38) PGYGJWFUCAHKOD-UHFFFAOYSA-N 531765 3-(5-((1-((4'-chloro-[1,1'-biphenyl]-2- yl)methyl)piperidin-4-yl)amino)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-03877 Protein cereblon Homo sapiens 1400 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531765 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531765&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440427 463795207 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237224 CC1(C)CCC(C(=O)N2CC(Cc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)C2)=C(c2ccc(F)cc2)C1 InChI=1S/C32H34FN3O4/c1-32(2)12-11-25(26(15-32)21-4-6-23(33)7-5-21)30(39)35-16-20(17-35)13-19-3-8-24-22(14-19)18-36(31(24)40)27-9-10-28(37)34-29(27)38/h3-8,14,20,27H,9-13,15-18H2,1-2H3,(H,34,37,38) RMHBEFMVTJYANW-UHFFFAOYSA-N 531766 3-(5-((1-(4'-fluoro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2- carbonyl)azetidin-3-yl)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05488 Protein cereblon Homo sapiens 600 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531766 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531766&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440784 463795208 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237225 O=C1CCC(N2Cc3cc(C(=O)N4CC5CN(Cc6ccccc6-c6ccc(Cl)cc6)CC5C4)ccc3C2=O)C(=O)N1 InChI=1S/C33H31ClN4O4/c34-26-8-5-20(6-9-26)27-4-2-1-3-22(27)14-36-15-24-17-37(18-25(24)16-36)32(41)21-7-10-28-23(13-21)19-38(33(28)42)29-11-12-30(39)35-31(29)40/h1-10,13,24-25,29H,11-12,14-19H2,(H,35,39,40) KYQYEZACOZILCQ-UHFFFAOYSA-N 531767 3-(5-(5-((4'-chloro-[1,1'-biphenyl]-2- yl)methyl)octahydropyrrolo[3,4-c]pyrrole- 2-carbonyl)-1-oxoisoindolin-2- yl)piperidine-2,6-dione::US20260028326, Compound GT-05642 Protein cereblon Homo sapiens 490 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531767 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531767&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440072 463795209 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237226 O=C1CCC(N2Cc3cc(C=C4CN(Cc5ccccc5-c5ccc(Cl)cc5)C4)ccc3C2=O)C(=O)N1 InChI=1S/C30H26ClN3O3/c31-24-8-6-21(7-9-24)25-4-2-1-3-22(25)17-33-15-20(16-33)13-19-5-10-26-23(14-19)18-34(30(26)37)27-11-12-28(35)32-29(27)36/h1-10,13-14,27H,11-12,15-18H2,(H,32,35,36) VXSJJWKVIRDHLP-UHFFFAOYSA-N 531768 3-(5-((1-((4'-chloro-[1,1'-biphenyl]-2- yl)methyl)azetidin-3-ylidene)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-03881 Protein cereblon Homo sapiens 480 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531768 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531768&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440164 463795210 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237227 CC1(C)CCC(C(=O)N2CC(=Cc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)C2)=C(c2ccc(F)cc2)C1 InChI=1S/C32H32FN3O4/c1-32(2)12-11-25(26(15-32)21-4-6-23(33)7-5-21)30(39)35-16-20(17-35)13-19-3-8-24-22(14-19)18-36(31(24)40)27-9-10-28(37)34-29(27)38/h3-8,13-14,27H,9-12,15-18H2,1-2H3,(H,34,37,38) JOQHPAIBWRLVSI-UHFFFAOYSA-N 531769 3-(5-((1-(4'-fluoro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2- carbonyl)azetidin-3-ylidene)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05489 Protein cereblon Homo sapiens 610 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531769 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531769&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 142754097 463795211 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237228 O=C1CCC(N2Cc3cc(C(=O)N4C5CC4CN(Cc4ccccc4-c4ccc(Cl)cc4)C5)ccc3C2=O)C(=O)N1 InChI=1S/C32H29ClN4O4/c33-23-8-5-19(6-9-23)26-4-2-1-3-21(26)15-35-17-24-14-25(18-35)37(24)31(40)20-7-10-27-22(13-20)16-36(32(27)41)28-11-12-29(38)34-30(28)39/h1-10,13,24-25,28H,11-12,14-18H2,(H,34,38,39) LRMAALONCKAXCF-UHFFFAOYSA-N 531770 3-(5-(3-((4'-chloro-[1,1'-biphenyl]-2- yl)methyl)-3,6-diazabicyclo[3.1.1]heptane- 6-carbonyl)-1-oxoisoindolin-2- yl)piperidine-2,6-dione::US20260028326, Compound GT-05643 Protein cereblon Homo sapiens 590 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531770 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531770&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440249 463795212 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237229 O=C1CCC(N2Cc3cc(C(O)C4(O)CN(Cc5ccccc5-c5ccc(Cl)cc5)C4)ccc3C2=O)C(=O)N1 InChI=1S/C30H28ClN3O5/c31-22-8-5-18(6-9-22)23-4-2-1-3-20(23)14-33-16-30(39,17-33)27(36)19-7-10-24-21(13-19)15-34(29(24)38)25-11-12-26(35)32-28(25)37/h1-10,13,25,27,36,39H,11-12,14-17H2,(H,32,35,37) CJJBHLWJSVFYCZ-UHFFFAOYSA-N 531771 3-(5-((1-((4'-chloro-[1,1'-biphenyl]-2- yl)methyl)-3-hydroxyazetidin-3- yl)(hydroxy)methyl)-1-oxoisoindolin-2- yl)piperidine-2,6-dione::US20260028326, Compound GT-03880 Protein cereblon Homo sapiens 230 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531771 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531771&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440393 463795213 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237230 CC1(C)CCC(C(=O)N2CC(O)(C(O)c3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)C2)=C(c2ccc(F)cc2)C1 InChI=1S/C32H34FN3O6/c1-31(2)12-11-23(24(14-31)18-3-6-21(33)7-4-18)29(40)35-16-32(42,17-35)27(38)19-5-8-22-20(13-19)15-36(30(22)41)25-9-10-26(37)34-28(25)39/h3-8,13,25,27,38,42H,9-12,14-17H2,1-2H3,(H,34,37,39) MTDYZEFCSKABGG-UHFFFAOYSA-N 531772 3-(5-((1-(4'-fluoro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-carbonyl)-3- hydroxyazetidin-3-yl)(hydroxy)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05490 Protein cereblon Homo sapiens 580 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531772 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531772&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440171 463795214 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237231 O=C1CCC(N2Cc3cc(CN4CCCN(C(=O)c5ccccc5-c5ccc(Cl)cc5)CC4)ccc3C2=O)C(=O)N1 InChI=1S/C32H31ClN4O4/c33-24-9-7-22(8-10-24)25-4-1-2-5-27(25)31(40)36-15-3-14-35(16-17-36)19-21-6-11-26-23(18-21)20-37(32(26)41)28-12-13-29(38)34-30(28)39/h1-2,4-11,18,28H,3,12-17,19-20H2,(H,34,38,39) YBNKJQMFHJHHCL-UHFFFAOYSA-N 531773 3-(5-((4-(4'-chloro-[1,1'-biphenyl]-2- carbonyl)-1,4-diazepan-1-yl)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05644 Protein cereblon Homo sapiens 590 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531773 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531773&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440769 463795215 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237232 O=C1CCC(N2Cc3cc(CC4CN(Cc5ccccc5-c5ccc(Cl)cc5)C4)ccc3C2=O)C(=O)N1 InChI=1S/C30H28ClN3O3/c31-24-8-6-21(7-9-24)25-4-2-1-3-22(25)17-33-15-20(16-33)13-19-5-10-26-23(14-19)18-34(30(26)37)27-11-12-28(35)32-29(27)36/h1-10,14,20,27H,11-13,15-18H2,(H,32,35,36) NXKJPPKTZIZRMR-UHFFFAOYSA-N 531774 3-(5-((1-((4'-chloro-[1,1'-biphenyl]-2- yl)methyl)azetidin-3-yl)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-03923 Protein cereblon Homo sapiens 170 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531774 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531774&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440054 463795216 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237233 CC1(C)CCC(C(=O)N2C3CCC2CN(c2ccc4c(c2)CN(C2CCC(=O)NC2=O)C4=O)C3)=C(c2ccc(F)cc2)C1 InChI=1S/C34H37FN4O4/c1-34(2)14-13-27(28(16-34)20-3-5-22(35)6-4-20)33(43)39-24-7-8-25(39)19-37(18-24)23-9-10-26-21(15-23)17-38(32(26)42)29-11-12-30(40)36-31(29)41/h3-6,9-10,15,24-25,29H,7-8,11-14,16-19H2,1-2H3,(H,36,40,41) AHWHLUQLGNAUGR-UHFFFAOYSA-N 531775 3-(5-(8-(4'-fluoro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-carbonyl)-3,8- diazabicyclo[3.2.1]octan-3-yl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05491 Protein cereblon Homo sapiens 970 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531775 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531775&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440566 463795217 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237234 O=C1CCC(N2Cc3cc(CN4CC5CN(C(=O)c6ccccc6-c6ccc(Cl)cc6)CC5C4)ccc3C2=O)C(=O)N1 InChI=1S/C33H31ClN4O4/c34-25-8-6-21(7-9-25)26-3-1-2-4-28(26)32(41)37-17-23-15-36(16-24(23)18-37)14-20-5-10-27-22(13-20)19-38(33(27)42)29-11-12-30(39)35-31(29)40/h1-10,13,23-24,29H,11-12,14-19H2,(H,35,39,40) FDNLAPABUHSJJC-UHFFFAOYSA-N 531776 3-(5-((5-(4'-chloro-[1,1'-biphenyl]-2- carbonyl)hexahydropyrrolo[3,4-c]pyrrol- 2(1H)-yl)methyl)-1-oxoisoindolin-2- yl)piperidine-2,6-dione::US20260028326, Compound GT-05645 Protein cereblon Homo sapiens 700 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531776 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531776&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440142 463795218 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237235 O=C1CCC(N2Cc3cc(CC4CN(C(=O)c5ccccc5-c5ccc(Cl)cc5)C4)ccc3C2=O)C(=O)N1 InChI=1S/C30H26ClN3O4/c31-22-8-6-20(7-9-22)23-3-1-2-4-25(23)29(37)33-15-19(16-33)13-18-5-10-24-21(14-18)17-34(30(24)38)26-11-12-27(35)32-28(26)36/h1-10,14,19,26H,11-13,15-17H2,(H,32,35,36) LHIIETLYYLSDRO-UHFFFAOYSA-N 531777 3-(5-((1-(4'-chloro-[1,1'-biphenyl]-2- carbonyl)azetidin-3-yl)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-03922 Protein cereblon Homo sapiens 160 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531777 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531777&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440165 463795219 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237236 CC1(C)CCC(C(=O)N2CC3CCC(C2)N3c2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)=C(c2ccc(F)cc2)C1 InChI=1S/C34H37FN4O4/c1-34(2)14-13-27(28(16-34)20-3-5-22(35)6-4-20)32(42)37-18-24-7-8-25(19-37)39(24)23-9-10-26-21(15-23)17-38(33(26)43)29-11-12-30(40)36-31(29)41/h3-6,9-10,15,24-25,29H,7-8,11-14,16-19H2,1-2H3,(H,36,40,41) VGGMWYXUDUTEGG-UHFFFAOYSA-N 531778 3-(5-(3-(4'-fluoro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-carbonyl)-3,8- diazabicyclo[3.2.1]octan-8-yl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05492 Protein cereblon Homo sapiens 830 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531778 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531778&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440261 463795220 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237237 O=C1CCC(N2Cc3cc(CN4CCN(Cc5ccccc5-c5cccs5)CC4)ccc3C2=O)C(=O)N1 InChI=1S/C29H30N4O3S/c34-27-10-9-25(28(35)30-27)33-19-22-16-20(7-8-24(22)29(33)36)17-31-11-13-32(14-12-31)18-21-4-1-2-5-23(21)26-6-3-15-37-26/h1-8,15-16,25H,9-14,17-19H2,(H,30,34,35) WDFCHPFDVXNXDX-UHFFFAOYSA-N 531779 3-(1-oxo-5-((4-(2-(thiophen-2- yl)benzyl)piperazin-1-yl)methyl)isoindolin- 2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05519 Protein cereblon Homo sapiens 410 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531779 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531779&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440783 463795221 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237238 CC1(C)CCC(CN2CCN(Cc3cc(F)c4c(c3)CN(C3CCC(=O)NC3=O)C4=O)CC2)=C(c2ccc(Cl)cc2)C1 InChI=1S/C33H38ClFN4O3/c1-33(2)10-9-23(26(17-33)22-3-5-25(34)6-4-22)19-38-13-11-37(12-14-38)18-21-15-24-20-39(32(42)30(24)27(35)16-21)28-7-8-29(40)36-31(28)41/h3-6,15-16,28H,7-14,17-20H2,1-2H3,(H,36,40,41) UTPVXOVJQDSFSH-UHFFFAOYSA-N 531780 3-(5-((4-((4'-chloro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2- yl)methyl)piperazin-1-yl)methyl)-7-fluoro- 1-oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-03469 Protein cereblon Homo sapiens 2120 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531780 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531780&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440104 463795222 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237239 CC1(C)CCC(CN2CC(Cc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)C2)=C(c2ccc(F)cc2)C1 InChI=1S/C32H36FN3O3/c1-32(2)12-11-23(27(15-32)22-4-6-25(33)7-5-22)18-35-16-21(17-35)13-20-3-8-26-24(14-20)19-36(31(26)39)28-9-10-29(37)34-30(28)38/h3-8,14,21,28H,9-13,15-19H2,1-2H3,(H,34,37,38) KOIPLLMRBPWFOG-UHFFFAOYSA-N 531781 3-(5-((1-((4'-fluoro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2- yl)methyl)azetidin-3-yl)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05493 Protein cereblon Homo sapiens 760 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531781 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531781&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440159 463795223 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237240 O=C1CCC(N2Cc3cc(C(=O)N4CCC(Nc5ccccc5-c5ccc(Cl)cc5)CC4)ccc3C2=O)C(=O)N1 InChI=1S/C31H29ClN4O4/c32-22-8-5-19(6-9-22)24-3-1-2-4-26(24)33-23-13-15-35(16-14-23)30(39)20-7-10-25-21(17-20)18-36(31(25)40)27-11-12-28(37)34-29(27)38/h1-10,17,23,27,33H,11-16,18H2,(H,34,37,38) AJXHDEMNYUYBMQ-UHFFFAOYSA-N 531782 3-(5-(4-((4'-chloro-[1,1'-biphenyl]-2- yl)amino)piperidine-1-carbonyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05646 Protein cereblon Homo sapiens 1020 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531782 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531782&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440423 463795224 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237241 CC1(C)CCC(C(=O)N2CC3CCC2CN3Cc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)=C(c2ccc(Cl)cc2)C1 InChI=1S/C35H39ClN4O4/c1-35(2)14-13-28(29(16-35)22-4-6-24(36)7-5-22)34(44)39-20-25-8-9-26(39)19-38(25)17-21-3-10-27-23(15-21)18-40(33(27)43)30-11-12-31(41)37-32(30)42/h3-7,10,15,25-26,30H,8-9,11-14,16-20H2,1-2H3,(H,37,41,42) QYSGPZSMMYKFOP-UHFFFAOYSA-N 531783 3-(5-((5-((4'-chloro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-yl)methyl)- 2,5-diazabicyclo[2.2.2]octan-2-yl)methyl)- 1-oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-04167 Protein cereblon Homo sapiens 660 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531783 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531783&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440403 463795225 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237242 CC1(C)CCC(CN2CC3CCC(C2)N3c2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)=C(c2ccc(F)cc2)C1 InChI=1S/C34H39FN4O3/c1-34(2)14-13-22(29(16-34)21-3-5-24(35)6-4-21)17-37-19-26-7-8-27(20-37)39(26)25-9-10-28-23(15-25)18-38(33(28)42)30-11-12-31(40)36-32(30)41/h3-6,9-10,15,26-27,30H,7-8,11-14,16-20H2,1-2H3,(H,36,40,41) DAWMGZLMWUNGGV-UHFFFAOYSA-N 531784 3-(5-(3-((4'-fluoro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-yl)methyl)- 3,8-diazabicyclo[3.2.1]octan-8-yl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05498 Protein cereblon Homo sapiens 1520 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531784 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531784&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 142754041 463795226 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237848 O=C1CCC(N2Cc3cc(CN4CCN(Cc5ccc(-c6ccc[nH]6)cc5)CC4)ccc3C2=O)C(=O)N1 InChI=1S/C29H31N5O3/c35-27-10-9-26(28(36)31-27)34-19-23-16-21(5-8-24(23)29(34)37)18-33-14-12-32(13-15-33)17-20-3-6-22(7-4-20)25-2-1-11-30-25/h1-8,11,16,26,30H,9-10,12-15,17-19H2,(H,31,35,36) QFICWJURWHGGJG-UHFFFAOYSA-N 531785 3-(5-((4-(4-(1H-pyrrol-2- yl)benzyl)piperazin-1-yl)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05734 Protein cereblon Homo sapiens 110 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531785 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531785&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440388 463795227 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237849 CC1(C)CCC(CN2CC3CCC2CN3Cc2ccc3c(c2F)CN(C2CCC(=O)NC2=O)C3=O)=C(c2ccc(Cl)cc2)C1 InChI=1S/C35H40ClFN4O3/c1-35(2)14-13-22(28(15-35)21-3-6-24(36)7-4-21)16-39-18-26-9-8-25(39)19-40(26)17-23-5-10-27-29(32(23)37)20-41(34(27)44)30-11-12-31(42)38-33(30)43/h3-7,10,25-26,30H,8-9,11-20H2,1-2H3,(H,38,42,43) ASVZXOKLTCEDCN-UHFFFAOYSA-N 531788 3-(5-((5-((4'-cholro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-yl)methyl)- 2,5-diazabicyclo[2.2.2]octan-2-yl)methyl)- 4-fluoro-1-oxoisoindolin-2-yl)piperidine- 2,6-dione::US20260028326, Compound GT-04168 Protein cereblon Homo sapiens 550 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531788 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531788&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440679 463795228 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237850 CC1(C)CCC(CN2CC(O)(C(O)c3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)C2)=C(c2ccc(F)cc2)C1 InChI=1S/C32H36FN3O5/c1-31(2)12-11-21(25(14-31)19-3-6-23(33)7-4-19)15-35-17-32(41,18-35)28(38)20-5-8-24-22(13-20)16-36(30(24)40)26-9-10-27(37)34-29(26)39/h3-8,13,26,28,38,41H,9-12,14-18H2,1-2H3,(H,34,37,39) BWZAJWGESUZTFX-UHFFFAOYSA-N 531789 3-(5-((1-((4'-fluoro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-yl)methyl)-3- hydroxyazetidin-3-yl)(hydroxy)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05499 Protein cereblon Homo sapiens 670 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531789 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531789&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440890 463795229 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237851 O=C1CCC(N2Cc3c(ccc(CN4CCN(C(=O)c5ccccc5-c5ccc(Cl)cc5)CC4)c3F)C2=O)C(=O)N1 InChI=1S/C31H28ClFN4O4/c32-21-8-5-19(6-9-21)22-3-1-2-4-23(22)30(40)36-15-13-35(14-16-36)17-20-7-10-24-25(28(20)33)18-37(31(24)41)26-11-12-27(38)34-29(26)39/h1-10,26H,11-18H2,(H,34,38,39) GNFDCDRUCBIRPJ-UHFFFAOYSA-N 531790 3-(5-((4-(4'-chloro-[1,1'-biphenyl]-2- carbonyl)piperazin-1-yl)methyl)-4-fluoro- 1-oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05649 Protein cereblon Homo sapiens 680 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531790 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531790&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440214 463795230 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237852 CC1(C)CCC(C(=O)N2CCN(Cc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)CC2)=C(c2ccc(Cl)cc2)C1 InChI=1S/C33H37ClN4O4/c1-33(2)12-11-26(27(18-33)22-4-6-24(34)7-5-22)31(41)37-15-13-36(14-16-37)19-21-3-8-25-23(17-21)20-38(32(25)42)28-9-10-29(39)35-30(28)40/h3-8,17,28H,9-16,18-20H2,1-2H3,(H,35,39,40) ATQRVOYSBJWFFA-UHFFFAOYSA-N 531791 3-(5-((4-(4'-chloro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2- carbonyl)piperazin-1-yl)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-04224 Protein cereblon Homo sapiens 430 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531791 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531791&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440178 463795231 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237853 CC1(C)CCC(CN2C3CCC2CN(c2ccc4c(c2)CN(C2CCC(=O)NC2=O)C4=O)C3)=C(c2ccc(F)cc2)C1 InChI=1S/C34H39FN4O3/c1-34(2)14-13-22(29(16-34)21-3-5-24(35)6-4-21)17-38-26-7-8-27(38)20-37(19-26)25-9-10-28-23(15-25)18-39(33(28)42)30-11-12-31(40)36-32(30)41/h3-6,9-10,15,26-27,30H,7-8,11-14,16-20H2,1-2H3,(H,36,40,41) YCVJPPRMJVXQTB-UHFFFAOYSA-N 531792 3-(5-(8-((4'-fluoro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-yl)methyl)- 3,8-diazabicyclo[3.2.1]octan-3-yl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05500 Protein cereblon Homo sapiens 1870 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531792 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531792&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 142754152 463795232 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237854 O=C1CCC(N2Cc3cc(CN4CCN(C(=O)c5ccccc5-c5ccc(Cl)cc5)CC4)c(F)cc3C2=O)C(=O)N1 InChI=1S/C31H28ClFN4O4/c32-22-7-5-19(6-8-22)23-3-1-2-4-24(23)30(40)36-13-11-35(12-14-36)17-21-15-20-18-37(31(41)25(20)16-26(21)33)27-9-10-28(38)34-29(27)39/h1-8,15-16,27H,9-14,17-18H2,(H,34,38,39) AEYHSWBTQHHWDY-UHFFFAOYSA-N 531793 3-(5-((4-(4'-chloro-[1,1'-biphenyl]-2- carbonyl)piperazin-1-yl)methyl)-6-fluoro- 1-oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05650 Protein cereblon Homo sapiens 940 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531793 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531793&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440254 463795233 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237855 O=C1CCC(N2Cc3cc(CN4CCN(Cc5ccccc5-c5ccc(F)cc5)CC4)ccc3C2=O)C(=O)N1 InChI=1S/C31H31FN4O3/c32-25-8-6-22(7-9-25)26-4-2-1-3-23(26)19-35-15-13-34(14-16-35)18-21-5-10-27-24(17-21)20-36(31(27)39)28-11-12-29(37)33-30(28)38/h1-10,17,28H,11-16,18-20H2,(H,33,37,38) CWSCWIYWTRPGJV-UHFFFAOYSA-N 531794 3-(5-((4-((4'-fluoro-[1,1'-biphenyl]-2- yl)methyl)piperazin-1-yl)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-04256 Protein cereblon Homo sapiens 1420 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531794 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531794&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440888 463795234 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237856 CC1(C)CCC(CN2CCCN(Cc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)CC2)=C(c2ccc(F)cc2)C1 InChI=1S/C34H41FN4O3/c1-34(2)13-12-25(29(19-34)24-5-7-27(35)8-6-24)21-38-15-3-14-37(16-17-38)20-23-4-9-28-26(18-23)22-39(33(28)42)30-10-11-31(40)36-32(30)41/h4-9,18,30H,3,10-17,19-22H2,1-2H3,(H,36,40,41) CDILXGOUNOEJOY-UHFFFAOYSA-N 531795 3-(5-((4-((4'-fluoro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-yl)methyl)- 1,4-diazepan-1-yl)methyl)-1-oxoisoindolin- 2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05504 Protein cereblon Homo sapiens 730 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531795 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531795&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 142754042 463795235 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237857 O=C1CCC(N2Cc3cc(CN4CCN(C(=O)c5ccccc5-c5ccc(Cl)cc5)CC4)cc(F)c3C2=O)C(=O)N1 InChI=1S/C31H28ClFN4O4/c32-22-7-5-20(6-8-22)23-3-1-2-4-24(23)30(40)36-13-11-35(12-14-36)17-19-15-21-18-37(31(41)28(21)25(33)16-19)26-9-10-27(38)34-29(26)39/h1-8,15-16,26H,9-14,17-18H2,(H,34,38,39) WJYYOEBEFOQULD-UHFFFAOYSA-N 531796 3-(5-((4-(4'-chloro-[1,1'-biphenyl]-2- carbonyl)piperazin-1-yl)methyl)-7-fluoro- 1-oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05700 Protein cereblon Homo sapiens 1220 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531796 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531796&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440231 463795236 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237858 O=C1CCC(N2Cc3cc(CN4CCN(C(=O)c5ccccc5-c5ccc(F)cc5)CC4)ccc3C2=O)C(=O)N1 InChI=1S/C31H29FN4O4/c32-23-8-6-21(7-9-23)24-3-1-2-4-26(24)30(39)35-15-13-34(14-16-35)18-20-5-10-25-22(17-20)19-36(31(25)40)27-11-12-28(37)33-29(27)38/h1-10,17,27H,11-16,18-19H2,(H,33,37,38) VBTBSYPGFZYQAJ-UHFFFAOYSA-N 531797 3-(5-((4-(4'-fluoro-[1,1'-biphenyl]-2- carbonyl)piperazin-1-yl)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-04194 Protein cereblon Homo sapiens 1160 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531797 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531797&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440562 463795237 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237859 CC1(C)CCC(CN2CCCN(C(=O)c3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)CC2)=C(c2ccc(F)cc2)C1 InChI=1S/C34H39FN4O4/c1-34(2)13-12-24(28(19-34)22-4-7-26(35)8-5-22)20-37-14-3-15-38(17-16-37)32(42)23-6-9-27-25(18-23)21-39(33(27)43)29-10-11-30(40)36-31(29)41/h4-9,18,29H,3,10-17,19-21H2,1-2H3,(H,36,40,41) MPUAXBZOYWQXFK-UHFFFAOYSA-N 531798 3-(5-(4-((4'-fluoro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-yl)methyl)- 1,4-diazepane-1-carbonyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05505 Protein cereblon Homo sapiens 810 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531798 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531798&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440793 463795238 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237860 O=C1CCC(N2Cc3c(CN4CCN(C(=O)c5ccccc5-c5ccc(Cl)cc5)CC4)cccc3C2=O)C(=O)N1 InChI=1S/C31H29ClN4O4/c32-22-10-8-20(9-11-22)23-5-1-2-6-24(23)30(39)35-16-14-34(15-17-35)18-21-4-3-7-25-26(21)19-36(31(25)40)27-12-13-28(37)33-29(27)38/h1-11,27H,12-19H2,(H,33,37,38) UGOWSFDKFQSPIU-UHFFFAOYSA-N 531799 3-(4-((4-(4'-chloro-[1,1'-biphenyl]-2- carbonyl)piperazin-1-yl)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05701 Protein cereblon Homo sapiens 1800 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531799 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531799&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440759 463795239 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237861 O=C1CCC(N2Cc3cc(CN4CCN(C(=O)C5=C(c6ccc(F)cc6)CCCC5)CC4)ccc3C2=O)C(=O)N1 InChI=1S/C31H33FN4O4/c32-23-8-6-21(7-9-23)24-3-1-2-4-26(24)30(39)35-15-13-34(14-16-35)18-20-5-10-25-22(17-20)19-36(31(25)40)27-11-12-28(37)33-29(27)38/h5-10,17,27H,1-4,11-16,18-19H2,(H,33,37,38) CIJCIUOGWKNXTC-UHFFFAOYSA-N 531800 3-(5-((4-((4'-fluoro-3,4,5,6-tetrahydro- [1,1'-biphenyl]-2-yl)methyl)piperazin-1- yl)methyl)-1-oxoisoindolin-2-yl)piperidine- 2,6-dione::US20260028326, Compound GT-04193 Protein cereblon Homo sapiens 460 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531800 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531800&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 142754151 463795240 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237862 CC1(C)CCC(CN2CCC3(CC2)CN(Cc2ccc4c(c2)CN(C2CCC(=O)NC2=O)C4=O)C3)=C(c2ccc(F)cc2)C1 InChI=1S/C36H43FN4O3/c1-35(2)12-11-26(30(18-35)25-4-6-28(37)7-5-25)20-39-15-13-36(14-16-39)22-40(23-36)19-24-3-8-29-27(17-24)21-41(34(29)44)31-9-10-32(42)38-33(31)43/h3-8,17,31H,9-16,18-23H2,1-2H3,(H,38,42,43) JMHHPQAIQIOYDB-UHFFFAOYSA-N 531801 3-(5-((7-((4'-fluoro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-yl)methyl)- 2,7-diazaspiro[3.5]nonan-2-yl)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05506 Protein cereblon Homo sapiens 540 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531801 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531801&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440198 463795241 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237863 Cn1nccc1-c1ccccc1CN1CCN(Cc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)CC1 InChI=1S/C29H32N6O3/c1-32-25(10-11-30-32)23-5-3-2-4-21(23)18-34-14-12-33(13-15-34)17-20-6-7-24-22(16-20)19-35(29(24)38)26-8-9-27(36)31-28(26)37/h2-7,10-11,16,26H,8-9,12-15,17-19H2,1H3,(H,31,36,37) IMOXBSCZDZSGHE-UHFFFAOYSA-N 531802 3-(5-((4-(2-(1-methyl-1H-pyrazol-5- yl)benzyl)piperazin-1-yl)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05702 Protein cereblon Homo sapiens 610 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531802 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531802&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 142322208 463795242 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237864 O=C1CCC(N2Cc3cc(CN4CCN(C(=O)C5=C(c6ccc(F)cc6)CCCC5)CC4)ccc3C2=O)C(=O)N1 InChI=1S/C31H33FN4O4/c32-23-8-6-21(7-9-23)24-3-1-2-4-26(24)30(39)35-15-13-34(14-16-35)18-20-5-10-25-22(17-20)19-36(31(25)40)27-11-12-28(37)33-29(27)38/h5-10,17,27H,1-4,11-16,18-19H2,(H,33,37,38) CIJCIUOGWKNXTC-UHFFFAOYSA-N 531803 3-(5-((4-(4'-fluoro-3,4,5,6-tetrahydro-[1,1'- biphenyl]-2-carbonyl)piperazin-1- yl)methyl)-1-oxoisoindolin-2-yl)piperidine- 2,6-dione::US20260028326, Compound GT-04170 Protein cereblon Homo sapiens 1010 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531803 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531803&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440200 463795243 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237865 CC1(C)CCC(CN2CCC3(CC2)CC(C(=O)c2ccc4c(c2)CN(C2CCC(=O)NC2=O)C4=O)C3)=C(c2ccc(F)cc2)C1 InChI=1S/C37H42FN3O4/c1-36(2)12-11-25(30(20-36)23-3-6-28(38)7-4-23)21-40-15-13-37(14-16-40)18-27(19-37)33(43)24-5-8-29-26(17-24)22-41(35(29)45)31-9-10-32(42)39-34(31)44/h3-8,17,27,31H,9-16,18-22H2,1-2H3,(H,39,42,44) ZLQKYAPOHMZEGH-UHFFFAOYSA-N 531804 3-(5-(7-((4'-fluoro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-yl)methyl)- 2,7-diazaspiro[3.5]nonane-2-carbonyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05507 Protein cereblon Homo sapiens 1240 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531804 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531804&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 142322202 463795244 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237866 O=C1CCC(N2Cc3cc(CN4CCN(Cc5cnccc5-c5ccc(Cl)cc5)CC4)ccc3C2=O)C(=O)N1 InChI=1S/C30H30ClN5O3/c31-24-4-2-21(3-5-24)25-9-10-32-16-23(25)18-35-13-11-34(12-14-35)17-20-1-6-26-22(15-20)19-36(30(26)39)27-7-8-28(37)33-29(27)38/h1-6,9-10,15-16,27H,7-8,11-14,17-19H2,(H,33,37,38) JWVVGJGLVTXRLK-UHFFFAOYSA-N 531805 3-(5-((4-((4-(4-chlorophenyl)pyridin-3- yl)methyl)piperazin-1-yl)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05703 Protein cereblon Homo sapiens 530 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531805 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531805&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 142754050 463795245 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237867 O=C1CCC(N2Cc3cc(CN4C5CC4CN(C(=O)C4=C(c6ccc(F)cc6)CCCC4)C5)ccc3C2=O)C(=O)N1 InChI=1S/C32H33FN4O4/c33-22-8-6-20(7-9-22)25-3-1-2-4-27(25)31(40)35-17-23-14-24(18-35)36(23)15-19-5-10-26-21(13-19)16-37(32(26)41)28-11-12-29(38)34-30(28)39/h5-10,13,23-24,28H,1-4,11-12,14-18H2,(H,34,38,39) KGBOKXLMEFANHM-UHFFFAOYSA-N 531806 3-(5-((3-(4'-fluoro-3,4,5,6-tetrahydro-[1,1'- biphenyl]-2-carbonyl)-3,6- diazabicyclo[3.1.1]heptan-6-yl)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-04169 Protein cereblon Homo sapiens 850 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531806 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531806&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 142754090 463795246 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237868 CC1(C)CCC(CN2CC3(C2)CN(C(=O)c2ccc4c(c2)CN(C2CCC(=O)NC2=O)C4=O)C3)=C(c2ccc(F)cc2)C1 InChI=1S/C34H37FN4O4/c1-33(2)12-11-23(27(14-33)21-3-6-25(35)7-4-21)15-37-17-34(18-37)19-38(20-34)31(42)22-5-8-26-24(13-22)16-39(32(26)43)28-9-10-29(40)36-30(28)41/h3-8,13,28H,9-12,14-20H2,1-2H3,(H,36,40,41) PUAJUKAXHVDCDK-UHFFFAOYSA-N 531807 3-(5-(6-((4'-fluoro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-yl)methyl)- 2,6-diazaspiro[3.3]heptane-2-carbonyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05508 Protein cereblon Homo sapiens 720 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531807 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531807&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 142754062 463795247 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237869 O=C1CCC(N2Cc3cc(CN4CC5CC(C4)N5Cc4ccccc4-c4ccc(Cl)cc4)ccc3C2=O)C(=O)N1 InChI=1S/C32H31ClN4O3/c33-24-8-6-21(7-9-24)27-4-2-1-3-22(27)16-36-25-14-26(36)19-35(18-25)15-20-5-10-28-23(13-20)17-37(32(28)40)29-11-12-30(38)34-31(29)39/h1-10,13,25-26,29H,11-12,14-19H2,(H,34,38,39) SGQJEHUYOOPRQA-UHFFFAOYSA-N 531808 3-(5-((6-((4'-chloro-[1,1'-biphenyl]-2- yl)methyl)-3,6-diazabicyclo[3.1.1]heptan- 3-yl)methyl)-1-oxoisoindolin-2- yl)piperidine-2,6-dione::US20260028326, Compound GT-05704 Protein cereblon Homo sapiens 680 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531808 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531808&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440557 463795248 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237870 O=C1CCC(N2Cc3cc(NC4CN(Cc5ccccc5-c5ccc(Cl)cc5)C4)c(F)cc3C2=O)C(=O)N1 InChI=1S/C29H26ClFN4O3/c30-20-7-5-17(6-8-20)22-4-2-1-3-18(22)13-34-15-21(16-34)32-25-11-19-14-35(29(38)23(19)12-24(25)31)26-9-10-27(36)33-28(26)37/h1-8,11-12,21,26,32H,9-10,13-16H2,(H,33,36,37) OQPMDRTUJQWVFN-UHFFFAOYSA-N 531809 3-(5-((1-((4'-chloro-[1,1'-biphenyl]-2- yl)methyl)azetidin-3-yl)amino)-6-fluoro-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-04204 Protein cereblon Homo sapiens 520 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531809 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531809&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440439 463795249 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237871 CC1(C)CCC(CN2C3CC2CN(Cc2ccc4c(c2)CN(C2CCC(=O)NC2=O)C4=O)C3)=C(c2ccc(F)cc2)C1 InChI=1S/C34H39FN4O3/c1-34(2)12-11-23(29(15-34)22-4-6-25(35)7-5-22)17-38-26-14-27(38)20-37(19-26)16-21-3-8-28-24(13-21)18-39(33(28)42)30-9-10-31(40)36-32(30)41/h3-8,13,26-27,30H,9-12,14-20H2,1-2H3,(H,36,40,41) HNNYYFRIFFKACZ-UHFFFAOYSA-N 531810 3-(5-((6-((4'-fluoro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-yl)methyl)- 3,6-diazabicyclo[3.1.1]heptan-3- yl)methyl)-1-oxoisoindolin-2-yl)piperidine- 2,6-dione::US20260028326, Compound GT-05509 Protein cereblon Homo sapiens 250 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531810 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531810&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440436 463795250 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237872 O=C1CCC(N2Cc3cc(C(=O)N4CC5CC(C4)N5Cc4ccccc4-c4ccc(Cl)cc4)ccc3C2=O)C(=O)N1 InChI=1S/C32H29ClN4O4/c33-23-8-5-19(6-9-23)26-4-2-1-3-21(26)15-36-24-14-25(36)18-35(17-24)31(40)20-7-10-27-22(13-20)16-37(32(27)41)28-11-12-29(38)34-30(28)39/h1-10,13,24-25,28H,11-12,14-18H2,(H,34,38,39) ONTZWYHKCQRARV-UHFFFAOYSA-N 531811 3-(5-(6-((4'-chloro-[1,1'-biphenyl]-2- yl)methyl)-3,6-diazabicyclo[3.1.1]heptane- 3-carbonyl)-1-oxoisoindolin-2- yl)piperidine-2,6-dione::US20260028326, Compound GT-05705 Protein cereblon Homo sapiens 880 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531811 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531811&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440204 463795251 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237873 O=C1CCC(N2Cc3cc(CN4CCN(Cc5ccncc5-c5ccc(Cl)cc5)CC4)ccc3C2=O)C(=O)N1 InChI=1S/C30H30ClN5O3/c31-24-4-2-21(3-5-24)26-16-32-10-9-22(26)18-35-13-11-34(12-14-35)17-20-1-6-25-23(15-20)19-36(30(25)39)27-7-8-28(37)33-29(27)38/h1-6,9-10,15-16,27H,7-8,11-14,17-19H2,(H,33,37,38) KWQMAZYUDINHFY-UHFFFAOYSA-N 531812 3-(5-((4-((3-(4-chlorophenyl)pyridin-4- yl)methyl)piperazin-1-yl)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-04275 Protein cereblon Homo sapiens 460 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531812 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531812&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440797 463795252 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237874 CC1(C)CCC(CN2C3CCC2CN(Cc2ccc4c(c2)CN(C2CCC(=O)NC2=O)C4=O)C3)=C(c2ccc(F)cc2)C1 InChI=1S/C35H41FN4O3/c1-35(2)14-13-24(30(16-35)23-4-6-26(36)7-5-23)18-39-27-8-9-28(39)21-38(20-27)17-22-3-10-29-25(15-22)19-40(34(29)43)31-11-12-32(41)37-33(31)42/h3-7,10,15,27-28,31H,8-9,11-14,16-21H2,1-2H3,(H,37,41,42) UFBLWQACICFWSM-UHFFFAOYSA-N 531813 3-(5-((8-((4'-fluoro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-yl)methyl)- 3,8-diazabicyclo[3.2.1]octan-3-yl)methyl)- 1-oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05510 Protein cereblon Homo sapiens 1220 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531813 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531813&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440117 463795253 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237875 O=C1CCC(N2Cc3cc(CN4CC5CC4CN5Cc4ccccc4-c4ccc(Cl)cc4)ccc3C2=O)C(=O)N1 InChI=1S/C32H31ClN4O3/c33-24-8-6-21(7-9-24)27-4-2-1-3-22(27)16-36-19-25-14-26(36)18-35(25)15-20-5-10-28-23(13-20)17-37(32(28)40)29-11-12-30(38)34-31(29)39/h1-10,13,25-26,29H,11-12,14-19H2,(H,34,38,39) HGGMLWMMWLWAIK-UHFFFAOYSA-N 531814 3-(5-((5-((4'-chloro-[1,1'-biphenyl]-2- yl)methyl)-2,5-diazabicyclo[2.2.1]heptan- 2-yl)methyl)-1-oxoisoindolin-2- yl)piperidine-2,6-dione::US20260028326, Compound GT-05707 Protein cereblon Homo sapiens 710 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531814 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531814&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440778 463795254 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237876 CC1(C)CCC(CN2CC3CCC2CN3Cc2cc3c(cc2F)C(=O)N(C2CCC(=O)NC2=O)C3)=C(c2ccc(Cl)cc2)C1 InChI=1S/C35H40ClFN4O3/c1-35(2)12-11-22(29(15-35)21-3-5-25(36)6-4-21)16-39-19-27-8-7-26(39)20-40(27)17-24-13-23-18-41(34(44)28(23)14-30(24)37)31-9-10-32(42)38-33(31)43/h3-6,13-14,26-27,31H,7-12,15-20H2,1-2H3,(H,38,42,43) WLLSTDVKBVHSHT-UHFFFAOYSA-N 531815 3-(5-((5-((4'-chloro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-yl)methyl)- 2,5-diazabicyclo[2.2.2]octan-2-yl)methyl)- 6-fluoro-1-oxoisoindolin-2-yl)piperidine- 2,6-dione::US20260028326, Compound GT-05460 Protein cereblon Homo sapiens 1630 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531815 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531815&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440426 463795255 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237877 CC1(C)CCC(CN2C3CCC2CN(C(=O)c2ccc4c(c2)CN(C2CCC(=O)NC2=O)C4=O)C3)=C(c2ccc(F)cc2)C1 InChI=1S/C35H39FN4O4/c1-35(2)14-13-23(29(16-35)21-3-6-25(36)7-4-21)17-39-26-8-9-27(39)20-38(19-26)33(43)22-5-10-28-24(15-22)18-40(34(28)44)30-11-12-31(41)37-32(30)42/h3-7,10,15,26-27,30H,8-9,11-14,16-20H2,1-2H3,(H,37,41,42) OIQSLCBYJRSGGR-UHFFFAOYSA-N 531817 3-(5-(8-((4'-fluoro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-yl)methyl)- 3,8-diazabicyclo[3.2.1]octane-3-carbonyl)- 1-oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05511 Protein cereblon Homo sapiens 1950 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531817 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531817&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 146396500 463795256 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237878 O=C1CCC(N2Cc3cc(CN4CC5(C4)CN(C(=O)c4ccccc4-c4ccc(Cl)cc4)C5)ccc3C2=O)C(=O)N1 InChI=1S/C32H29ClN4O4/c33-23-8-6-21(7-9-23)24-3-1-2-4-26(24)30(40)36-18-32(19-36)16-35(17-32)14-20-5-10-25-22(13-20)15-37(31(25)41)27-11-12-28(38)34-29(27)39/h1-10,13,27H,11-12,14-19H2,(H,34,38,39) MKVWMFLURJPRRF-UHFFFAOYSA-N 531818 3-(5-((6-(4'-chloro-[1,1'-biphenyl]-2- carbonyl)-2,6-diazaspiro[3.3]heptan-2- yl)methyl)-1-oxoisoindolin-2-yl)piperidine- 2,6-dione::US20260028326, Compound GT-05708 Protein cereblon Homo sapiens 550 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531818 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531818&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440267 463795257 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237879 CC1(C)CCC(C(=O)N2CCN(Cc3ccc(-c4ccc5c(c4)CN(C4CCC(=O)NC4=O)C5=O)cc3)CC2)=C(c2ccc(Cl)cc2)C1 InChI=1S/C39H41ClN4O4/c1-39(2)16-15-32(33(22-39)27-7-10-30(40)11-8-27)37(47)43-19-17-42(18-20-43)23-25-3-5-26(6-4-25)28-9-12-31-29(21-28)24-44(38(31)48)34-13-14-35(45)41-36(34)46/h3-12,21,34H,13-20,22-24H2,1-2H3,(H,41,45,46) PQZZNMGXNOKPDA-UHFFFAOYSA-N 531819 3-(5-(4-((4-(4'-chloro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2- carbonyl)piperazin-1-yl)methyl)phenyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05359 Protein cereblon Homo sapiens 970 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531819 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531819&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440468 463795258 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237880 CC1(C)CCC(CN2CC3CCC2CN3Cc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)=C(c2ccc(F)cc2)C1 InChI=1S/C35H41FN4O3/c1-35(2)14-13-24(30(16-35)23-4-6-26(36)7-5-23)18-39-21-27-8-9-28(39)20-38(27)17-22-3-10-29-25(15-22)19-40(34(29)43)31-11-12-32(41)37-33(31)42/h3-7,10,15,27-28,31H,8-9,11-14,16-21H2,1-2H3,(H,37,41,42) VOFHLQLJODWZIQ-UHFFFAOYSA-N 531820 3-(5-((5-((4'-fluoro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-yl)methyl)- 2,5-diazabicyclo[2.2.2]octan-2-yl)methyl)- 1-oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05512 Protein cereblon Homo sapiens 570 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531820 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531820&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440863 463795259 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237881 O=C1CCC(N2Cc3cc(CN4CC5(C4)CN(Cc4ccccc4-c4ccc(Cl)cc4)C5)ccc3C2=O)C(=O)N1 InChI=1S/C32H31ClN4O3/c33-25-8-6-22(7-9-25)26-4-2-1-3-23(26)15-36-19-32(20-36)17-35(18-32)14-21-5-10-27-24(13-21)16-37(31(27)40)28-11-12-29(38)34-30(28)39/h1-10,13,28H,11-12,14-20H2,(H,34,38,39) HXZIVJGUBQLPOA-UHFFFAOYSA-N 531821 3-(5-((6-((4'-chloro-[1,1'-biphenyl]-2- yl)methyl)-2,6-diazaspiro[3.3]heptan-2- yl)methyl)-1-oxoisoindolin-2-yl)piperidine- 2,6-dione::US20260028326, Compound GT-05709 Protein cereblon Homo sapiens 660 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531821 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531821&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440573 463795260 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237882 CC1(C)CCC(CN2CCN(CCc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)CC2)=C(c2ccc(Cl)cc2)C1 InChI=1S/C34H41ClN4O3/c1-34(2)13-11-25(29(20-34)24-4-6-27(35)7-5-24)21-38-17-15-37(16-18-38)14-12-23-3-8-28-26(19-23)22-39(33(28)42)30-9-10-31(40)36-32(30)41/h3-8,19,30H,9-18,20-22H2,1-2H3,(H,36,40,41) GNKBJUAWLGNEQP-UHFFFAOYSA-N 531822 3-(5-(2-(4-((4'-chloro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2- yl)methyl)piperazin-1-yl)ethyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05361 Protein cereblon Homo sapiens 370 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531822 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531822&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440550 463795261 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237883 CC1(C)CCC(CN2C3CCC2CN(C(=O)c2ccc4c(c2)CN(C2CCC(=O)NC2=O)C4=O)C3)=C(c2ccc(F)cc2)C1 InChI=1S/C35H39FN4O4/c1-35(2)14-13-23(29(16-35)21-3-6-25(36)7-4-21)17-39-26-8-9-27(39)20-38(19-26)33(43)22-5-10-28-24(15-22)18-40(34(28)44)30-11-12-31(41)37-32(30)42/h3-7,10,15,26-27,30H,8-9,11-14,16-20H2,1-2H3,(H,37,41,42) OIQSLCBYJRSGGR-UHFFFAOYSA-N 531823 3-(5-(5-((4'-fluoro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-yl)methyl)- 2,5-diazabicyclo[2.2.2]octane-2-carbonyl)- 1-oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05513 Protein cereblon Homo sapiens 970 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531823 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531823&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440893 463795262 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237884 O=C1CCC(N2Cc3cc(CN4C5CCC4CN(Cc4ccccc4-c4ccc(Cl)cc4)C5)ccc3C2=O)C(=O)N1 InChI=1S/C33H33ClN4O3/c34-25-8-6-22(7-9-25)28-4-2-1-3-23(28)17-36-19-26-10-11-27(20-36)37(26)16-21-5-12-29-24(15-21)18-38(33(29)41)30-13-14-31(39)35-32(30)40/h1-9,12,15,26-27,30H,10-11,13-14,16-20H2,(H,35,39,40) IBJBNMPNXRUOPB-UHFFFAOYSA-N 531825 3-(5-((3-((4'-chloro-[1,1'-biphenyl]-2- yl)methyl)-3,8-diazabicyclo[3.2.1]octan-8- yl)methyl)-1-oxoisoindolin-2-yl)piperidine- 2,6-dione::US20260028326, Compound GT-05710 Protein cereblon Homo sapiens 1100 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531825 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531825&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440309 463795263 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237885 CC1(C)CCC(CN2CCN(CCCc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)CC2)=C(c2ccc(Cl)cc2)C1 InChI=1S/C35H43ClN4O3/c1-35(2)14-13-26(30(21-35)25-6-8-28(36)9-7-25)22-39-18-16-38(17-19-39)15-3-4-24-5-10-29-27(20-24)23-40(34(29)43)31-11-12-32(41)37-33(31)42/h5-10,20,31H,3-4,11-19,21-23H2,1-2H3,(H,37,41,42) ISCUWCRICVFTIX-UHFFFAOYSA-N 531826 3-(5-(3-(4-((4'-chloro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2- yl)methyl)piperazin-1-yl)propyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05362 Protein cereblon Homo sapiens 1260 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531826 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531826&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440578 463795264 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237886 CC1(C)CCC(C(=O)N2CC3CC(C2)N3Cc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)=C(c2ccc(F)cc2)C1 InChI=1S/C34H37FN4O4/c1-34(2)12-11-27(28(15-34)21-4-6-23(35)7-5-21)32(42)37-18-24-14-25(19-37)38(24)16-20-3-8-26-22(13-20)17-39(33(26)43)29-9-10-30(40)36-31(29)41/h3-8,13,24-25,29H,9-12,14-19H2,1-2H3,(H,36,40,41) XGRHOUMGWHIKLQ-UHFFFAOYSA-N 531827 3-(5-((3-(4'-fluoro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-carbonyl)-3,6- diazabicyclo[3.1.1]heptan-6-yl)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05514 Protein cereblon Homo sapiens 740 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531827 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531827&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440404 463795265 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237887 O=C1CCC(N2Cc3cc(CN4CCN(Cc5ccccc5-c5ccc(Cl)cc5)CC4C(F)(F)F)ccc3C2=O)C(=O)N1 InChI=1S/C32H30ClF3N4O3/c33-24-8-6-21(7-9-24)25-4-2-1-3-22(25)17-38-13-14-39(28(19-38)32(34,35)36)16-20-5-10-26-23(15-20)18-40(31(26)43)27-11-12-29(41)37-30(27)42/h1-10,15,27-28H,11-14,16-19H2,(H,37,41,42) MNQWRDHMMMXESQ-UHFFFAOYSA-N 531828 3-(5-((4-((4'-chloro-[1,1'-biphenyl]-2- yl)methyl)-2-(trifluoromethyl)piperazin-1- yl)methyl)-1-oxoisoindolin-2-yl)piperidine- 2,6-dione::US20260028326, Compound GT-05711 Protein cereblon Homo sapiens 490 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531828 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531828&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440269 463795266 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237888 CC1(C)CCC(CN2CCN(C(=O)c3ccc4c(c3)C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)=C(c2ccc(Cl)cc2)C1 InChI=1S/C33H35ClN4O5/c1-33(2)12-11-22(26(18-33)20-3-6-23(34)7-4-20)19-36-13-15-37(16-14-36)30(41)21-5-8-24-25(17-21)32(43)38(31(24)42)27-9-10-28(39)35-29(27)40/h3-8,17,27H,9-16,18-19H2,1-2H3,(H,35,39,40) OXJFJAWLVXGUCJ-UHFFFAOYSA-N 531829 5-(4-((4'-chloro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2- yl)methyl)piperazine-1-carbonyl)-2-(2,6- dioxopiperidin-3-yl)isoindoline-1,3-dione::US20260028326, Compound GT-05366 Protein cereblon Homo sapiens 1440 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531829 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531829&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 142754043 463795267 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237889 CC1(C)CCC(C(=O)N2C3CC2CN(Cc2ccc4c(c2)CN(C2CCC(=O)NC2=O)C4=O)C3)=C(c2ccc(F)cc2)C1 InChI=1S/C34H37FN4O4/c1-34(2)12-11-27(28(15-34)21-4-6-23(35)7-5-21)33(43)39-24-14-25(39)19-37(18-24)16-20-3-8-26-22(13-20)17-38(32(26)42)29-9-10-30(40)36-31(29)41/h3-8,13,24-25,29H,9-12,14-19H2,1-2H3,(H,36,40,41) IPYUBVPCNWSHKP-UHFFFAOYSA-N 531830 3-(5-((6-(4'-fluoro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-carbonyl)-3,6- diazabicyclo[3.1.1]heptan-3-yl)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05515 Protein cereblon Homo sapiens 1010 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531830 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531830&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440487 463795268 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237890 O=C1CCC(N2Cc3cc(CN4CCN(C(=O)c5ccncc5-c5ccc(Cl)cc5)CC4)ccc3C2=O)C(=O)N1 InChI=1S/C30H28ClN5O4/c31-22-4-2-20(3-5-22)25-16-32-10-9-24(25)29(39)35-13-11-34(12-14-35)17-19-1-6-23-21(15-19)18-36(30(23)40)26-7-8-27(37)33-28(26)38/h1-6,9-10,15-16,26H,7-8,11-14,17-18H2,(H,33,37,38) SVHGSFSNLVDRAO-UHFFFAOYSA-N 531831 3-(5-((4-(3-(4- chlorophenyl)isonicotinoyl)piperazin-1- yl)methyl)-1-oxoisoindolin-2-yl)piperidine- 2,6-dione::US20260028326, Compound GT-04222 Protein cereblon Homo sapiens 560 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531831 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531831&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 142754068 463795269 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237891 CC1(C)CCC(CN2CC3CC(C2)N3Cc2cc3c(cc2F)C(=O)N(C2CCC(=O)NC2=O)C3)=C(c2ccc(Cl)cc2)C1 InChI=1S/C34H38ClFN4O3/c1-34(2)10-9-21(28(14-34)20-3-5-24(35)6-4-20)15-38-18-25-12-26(19-38)39(25)17-23-11-22-16-40(33(43)27(22)13-29(23)36)30-7-8-31(41)37-32(30)42/h3-6,11,13,25-26,30H,7-10,12,14-19H2,1-2H3,(H,37,41,42) BNANYTDOVAEOJN-UHFFFAOYSA-N 531832 3-(5-((3-((4'-chloro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-yl)methyl)- 3,6-diazabicyclo[3.1.1]heptan-6- yl)methyl)-6-fluoro-1-oxoisoindolin-2- yl)piperidine-2,6-dione::US20260028326, Compound GT-05367 Protein cereblon Homo sapiens 400 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531832 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531832&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440461 463795270 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237892 CC1(C)CCC(C(=O)N2CC3CCC(C2)N3Cc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)=C(c2ccc(F)cc2)C1 InChI=1S/C35H39FN4O4/c1-35(2)14-13-28(29(16-35)22-4-6-24(36)7-5-22)33(43)38-19-25-8-9-26(20-38)39(25)17-21-3-10-27-23(15-21)18-40(34(27)44)30-11-12-31(41)37-32(30)42/h3-7,10,15,25-26,30H,8-9,11-14,16-20H2,1-2H3,(H,37,41,42) VLMHFQAHOMYADL-UHFFFAOYSA-N 531833 3-(5-((3-(4'-fluoro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-carbonyl)-3,8- diazabicyclo[3.2.1]octan-8-yl)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05516 Protein cereblon Homo sapiens 600 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531833 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531833&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 163200970 463795271 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237893 O=C1CCC(N2Cc3cc(CN4C5CCC4CN(C(=O)c4ccccc4-c4ccc(Cl)cc4)C5)ccc3C2=O)C(=O)N1 InChI=1S/C33H31ClN4O4/c34-23-8-6-21(7-9-23)26-3-1-2-4-28(26)32(41)36-18-24-10-11-25(19-36)37(24)16-20-5-12-27-22(15-20)17-38(33(27)42)29-13-14-30(39)35-31(29)40/h1-9,12,15,24-25,29H,10-11,13-14,16-19H2,(H,35,39,40) ORBGEXLYRJHIKZ-UHFFFAOYSA-N 531834 3-(5-((3-(4'-chloro-[1,1'-biphenyl]-2- carbonyl)-3,8-diazabicyclo[3.2.1]octan-8- yl)methyl)-1-oxoisoindolin-2-yl)piperidine- 2,6-dione::US20260028326, Compound GT-05788 Protein cereblon Homo sapiens 500 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531834 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531834&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440185 463795272 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237894 CC1(C)CCC(C(=O)N2CC3CC(C2)N3Cc2ccc3c(c2)C(=O)N(C2CCC(=O)NC2=O)C3=O)=C(c2ccc(Cl)cc2)C1 InChI=1S/C34H35ClN4O5/c1-34(2)12-11-25(27(15-34)20-4-6-21(35)7-5-20)31(42)37-17-22-14-23(18-37)38(22)16-19-3-8-24-26(13-19)33(44)39(32(24)43)28-9-10-29(40)36-30(28)41/h3-8,13,22-23,28H,9-12,14-18H2,1-2H3,(H,36,40,41) BDDUQXKGEXRZHF-UHFFFAOYSA-N 531835 5-((3-((4'-chloro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-yl)methyl)- 3,6-diazabicyclo[3.1.1]heptan-6- yl)methyl)-2-(2,6-dioxopiperidin-3- yl)isoindoline-1,3-dione::US20260028326, Compound GT-05368 Protein cereblon Homo sapiens 1800 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531835 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531835&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440433 463795273 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237895 CC1(C)CCC(C(=O)N2C3CCC2CN(Cc2ccc4c(c2)CN(C2CCC(=O)NC2=O)C4=O)C3)=C(c2ccc(F)cc2)C1 InChI=1S/C35H39FN4O4/c1-35(2)14-13-28(29(16-35)22-4-6-24(36)7-5-22)34(44)40-25-8-9-26(40)20-38(19-25)17-21-3-10-27-23(15-21)18-39(33(27)43)30-11-12-31(41)37-32(30)42/h3-7,10,15,25-26,30H,8-9,11-14,16-20H2,1-2H3,(H,37,41,42) VCADLHODKXQSSI-UHFFFAOYSA-N 531836 3-(5-((8-(4'-fluoro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-carbonyl)-3,8- diazabicyclo[3.2.1]octan-3-yl)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05517 Protein cereblon Homo sapiens 600 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531836 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531836&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440476 463795274 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237896 O=C1CCC(N2Cc3cc(CN4CCN(C(=O)c5ccccc5-c5ccc(Cl)cc5)CC4C(F)(F)F)ccc3C2=O)C(=O)N1 InChI=1S/C32H28ClF3N4O4/c33-22-8-6-20(7-9-22)23-3-1-2-4-25(23)30(43)39-14-13-38(27(18-39)32(34,35)36)16-19-5-10-24-21(15-19)17-40(31(24)44)26-11-12-28(41)37-29(26)42/h1-10,15,26-27H,11-14,16-18H2,(H,37,41,42) QKIQTGSNKFXEMB-UHFFFAOYSA-N 531837 3-(5-((4-(4'-chloro-[1,1'-biphenyl]-2- carbonyl)-2-(trifluoromethyl)piperazin-1- yl)methyl)-1-oxoisoindolin-2-yl)piperidine- 2,6-dione::US20260028326, Compound GT-05789 Protein cereblon Homo sapiens 520 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531837 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531837&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440296 463795275 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237897 O=C1CCC(N2C(=O)c3ccc(N4CC5CC(C4)N5Cc4ccccc4-c4ccc(Cl)cc4)cc3C2=O)C(=O)N1 InChI=1S/C31H27ClN4O4/c32-20-7-5-18(6-8-20)24-4-2-1-3-19(24)15-35-22-13-23(35)17-34(16-22)21-9-10-25-26(14-21)31(40)36(30(25)39)27-11-12-28(37)33-29(27)38/h1-10,14,22-23,27H,11-13,15-17H2,(H,33,37,38) ARVMAARBXAIDJB-UHFFFAOYSA-N 531838 5-(6-((4'-chloro-[1,1'-biphenyl]-2- yl)methyl)-3,6-diazabicyclo[3.1.1]heptan- 3-yl)-2-(2,6-dioxopiperidin-3- yl)isoindoline-1,3-dione::US20260028326, Compound GT-05373 Protein cereblon Homo sapiens 1490 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531838 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531838&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440469 463795276 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237898 O=C1CCC(N2Cc3cc(CN4CCN(Cc5ccc(-c6cccs6)cc5)CC4)ccc3C2=O)C(=O)N1 InChI=1S/C29H30N4O3S/c34-27-10-9-25(28(35)30-27)33-19-23-16-21(5-8-24(23)29(33)36)18-32-13-11-31(12-14-32)17-20-3-6-22(7-4-20)26-2-1-15-37-26/h1-8,15-16,25H,9-14,17-19H2,(H,30,34,35) RHHGYLJKFDNPFG-UHFFFAOYSA-N 531839 3-(1-oxo-5-((4-(4-(thiophen-2- yl)benzyl)piperazin-1-yl)methyl)isoindolin- 2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05640 Protein cereblon Homo sapiens 390 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531839 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531839&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440772 463795277 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237899 CC1(C)CCC(CN2CCN(Cc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)CC2)=C(c2ccco2)C1 InChI=1S/C31H38N4O4/c1-31(2)10-9-22(25(17-31)27-4-3-15-39-27)19-34-13-11-33(12-14-34)18-21-5-6-24-23(16-21)20-35(30(24)38)26-7-8-28(36)32-29(26)37/h3-6,15-16,26H,7-14,17-20H2,1-2H3,(H,32,36,37) JUTPRUWTEFINPN-UHFFFAOYSA-N 531840 3-(5-((4-((2-(furan-2-yl)-4,4- dimethylcyclohex-1-en-1- yl)methyl)piperazin-1-yl)methyl)-1- oxoisindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05790 Protein cereblon Homo sapiens 570 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531840 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531840&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440180 463795278 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237900 O=C1CCC(N2C(=O)c3ccc(N4CC5CCC4CN5Cc4ccccc4-c4ccc(Cl)cc4)cc3C2=O)C(=O)N1 InChI=1S/C32H29ClN4O4/c33-21-7-5-19(6-8-21)25-4-2-1-3-20(25)16-35-17-24-10-9-23(35)18-36(24)22-11-12-26-27(15-22)32(41)37(31(26)40)28-13-14-29(38)34-30(28)39/h1-8,11-12,15,23-24,28H,9-10,13-14,16-18H2,(H,34,38,39) UEHUYIQEWRHNAW-UHFFFAOYSA-N 531841 5-(5-((4'-chloro-[1,1'-biphenyl]-2- yl)methyl)-2,5-diazabicyclo[2.2.2]octan-2- yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline- 1,3-dione::US20260028326, Compound GT-05374 Protein cereblon Homo sapiens 520 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531841 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531841&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440133 463795279 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237901 CC1(C)CCC(C(=O)N2CCN(Cc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)CC2)=C(c2ccc(F)cc2)C1 InChI=1S/C33H37FN4O4/c1-33(2)12-11-26(27(18-33)22-4-6-24(34)7-5-22)31(41)37-15-13-36(14-16-37)19-21-3-8-25-23(17-21)20-38(32(25)42)28-9-10-29(39)35-30(28)40/h3-8,17,28H,9-16,18-20H2,1-2H3,(H,35,39,40) JBUQOQHJCQVLDD-UHFFFAOYSA-N 531842 3-(5-((4-(4'-fluoro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2- carbonyl)piperazin-1-yl)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05520 Protein cereblon Homo sapiens 350 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531842 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531842&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 142754146 463795280 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237902 CC1(C)CCC(CN2CCN(Cc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)CC2)=C(c2cncs2)C1 InChI=1S/C30H37N5O3S/c1-30(2)8-7-21(24(14-30)26-15-31-19-39-26)17-34-11-9-33(10-12-34)16-20-3-4-23-22(13-20)18-35(29(23)38)25-5-6-27(36)32-28(25)37/h3-4,13,15,19,25H,5-12,14,16-18H2,1-2H3,(H,32,36,37) ZJQVJDGAZUMUFY-UHFFFAOYSA-N 531843 3-(5-((4-((4,4-dimethyl-2-(thiazol-5- yl)cyclohex-1-en-1-yl)methyl)piperazin-1- yl)methyl)-1-oxoisoindolin-2-yl)piperidine- 2,6-dione::US20260028326, Compound GT-05791 Protein cereblon Homo sapiens 730 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531843 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531843&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 142754120 463795281 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237903 CC1(C)CCC(CN2C3CC2CN(c2ccc4c(c2)C(=O)N(C2CCC(=O)NC2=O)C4=O)C3)=C(c2ccc(Cl)cc2)C1 InChI=1S/C33H35ClN4O4/c1-33(2)12-11-20(27(15-33)19-3-5-21(34)6-4-19)16-37-23-13-24(37)18-36(17-23)22-7-8-25-26(14-22)32(42)38(31(25)41)28-9-10-29(39)35-30(28)40/h3-8,14,23-24,28H,9-13,15-18H2,1-2H3,(H,35,39,40) QBTVARGRCQVBSE-UHFFFAOYSA-N 531844 5-(6-((4'-chloro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-yl)methyl)- 3,6-diazabicyclo[3.1.1]heptan-3-yl)-2-(2,6- dioxopiperidin-3-yl)isoindoline-1,3-dione::US20260028326, Compound GT-05378 Protein cereblon Homo sapiens 1770 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531844 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531844&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 142754150 463795282 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237904 CC1(C)CCC(C(=O)N2CC3CC(C2)N3Cc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)=C(c2ccc(Cl)cc2)C1 InChI=1S/C34H37ClN4O4/c1-34(2)12-11-27(28(15-34)21-4-6-23(35)7-5-21)32(42)37-18-24-14-25(19-37)38(24)16-20-3-8-26-22(13-20)17-39(33(26)43)29-9-10-30(40)36-31(29)41/h3-8,13,24-25,29H,9-12,14-19H2,1-2H3,(H,36,40,41) ZKOPEBAJGNILGO-UHFFFAOYSA-N 531845 3-(5-((3-(4'-chloro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-carbonyl)-3,6- diazabicyclo[3.1.1]heptan-6-yl)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05521 Protein cereblon Homo sapiens 620 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531845 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531845&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 142754096 463795283 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237905 Cc1ccc(C2=C(CN3CCN(Cc4ccc5c(c4)CN(C4CCC(=O)NC4=O)C5=O)CC3)CCC(C)(C)C2)cc1 InChI=1S/C34H42N4O3/c1-23-4-7-25(8-5-23)29-19-34(2,3)13-12-26(29)21-37-16-14-36(15-17-37)20-24-6-9-28-27(18-24)22-38(33(28)41)30-10-11-31(39)35-32(30)40/h4-9,18,30H,10-17,19-22H2,1-3H3,(H,35,39,40) SSLWPSMKNRWKIJ-UHFFFAOYSA-N 531846 3-(1-oxo-5-((4-((4',5,5-trimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2- yl)methyl)piperazin-1- yl)methyl)isoindolin-2-yl)piperidine-2,6- dione::US20260028326, Compound GT-05792 Protein cereblon Homo sapiens 660 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531846 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531846&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440892 463795284 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237906 CC1(C)CCC(CN2CC3CCC2CN3c2ccc3c(c2)C(=O)N(C2CCC(=O)NC2=O)C3=O)=C(c2ccc(Cl)cc2)C1 InChI=1S/C34H37ClN4O4/c1-34(2)14-13-21(28(16-34)20-3-5-22(35)6-4-20)17-37-18-25-8-7-24(37)19-38(25)23-9-10-26-27(15-23)33(43)39(32(26)42)29-11-12-30(40)36-31(29)41/h3-6,9-10,15,24-25,29H,7-8,11-14,16-19H2,1-2H3,(H,36,40,41) VRMNRXJDVFVMTP-UHFFFAOYSA-N 531847 5-(5-((4'-chloro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-yl)methyl)- 2,5-diazabicyclo[2.2.2]octan-2-yl)-2-(2,6- dioxopiperidin-3-yl)isoindoline-1,3-dione::US20260028326, Compound GT-05379 Protein cereblon Homo sapiens 110 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531847 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531847&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 142754165 463795285 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237907 CC1(C)CCC(C(=O)N2CC3CCC(C2)N3Cc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)=C(c2ccc(Cl)cc2)C1 InChI=1S/C35H39ClN4O4/c1-35(2)14-13-28(29(16-35)22-4-6-24(36)7-5-22)33(43)38-19-25-8-9-26(20-38)39(25)17-21-3-10-27-23(15-21)18-40(34(27)44)30-11-12-31(41)37-32(30)42/h3-7,10,15,25-26,30H,8-9,11-14,16-20H2,1-2H3,(H,37,41,42) JWKAKJAQSINENW-UHFFFAOYSA-N 531848 3-(5-((3-(4'-chloro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-carbonyl)-3,8- diazabicyclo[3.2.1]octan-8-yl)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05522 Protein cereblon Homo sapiens 480 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531848 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531848&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 146396505 463795286 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237908 CC1(C)CCC(CN2CC3CCC2CN3C(=O)c2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)=C(c2ccc(Cl)cc2)C1 InChI=1S/C35H39ClN4O4/c1-35(2)14-13-23(29(16-35)21-3-6-25(36)7-4-21)17-38-19-27-9-8-26(38)20-39(27)33(43)22-5-10-28-24(15-22)18-40(34(28)44)30-11-12-31(41)37-32(30)42/h3-7,10,15,26-27,30H,8-9,11-14,16-20H2,1-2H3,(H,37,41,42) WCHJKFCJSXYHHT-UHFFFAOYSA-N 531849 3-(5-(5-((4'-chloro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-yl)methyl)- 2,5-diazabicyclo[2.2.2]octane-2-carbonyl)- 1-oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05795 Protein cereblon Homo sapiens 940 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531849 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531849&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 142754144 463795287 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237909 O=C1CCC(N2Cc3cc(NC4CN(Cc5ccccc5-c5ccc(Cl)cc5)C4)ccc3C2=O)C(=O)N1 InChI=1S/C29H27ClN4O3/c30-21-7-5-18(6-8-21)24-4-2-1-3-19(24)14-33-16-23(17-33)31-22-9-10-25-20(13-22)15-34(29(25)37)26-11-12-27(35)32-28(26)36/h1-10,13,23,26,31H,11-12,14-17H2,(H,32,35,36) XGOLPNZKDRYIBT-UHFFFAOYSA-N 531850 3-(5-((1-((4'-chloro-[1,1'-biphenyl]-2- yl)methyl)azetidin-3-yl)amino)-1- oxoisoindolin-2-yl)piperidine-2,6- dione::US20260028326, Compound GT-05382 Protein cereblon Homo sapiens 660 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531850 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531850&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 142754059 463795288 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237910 CC1(C)CCC(C(=O)N2C3CCC2CN(Cc2ccc4c(c2)CN(C2CCC(=O)NC2=O)C4=O)C3)=C(c2ccc(Cl)cc2)C1 InChI=1S/C35H39ClN4O4/c1-35(2)14-13-28(29(16-35)22-4-6-24(36)7-5-22)34(44)40-25-8-9-26(40)20-38(19-25)17-21-3-10-27-23(15-21)18-39(33(27)43)30-11-12-31(41)37-32(30)42/h3-7,10,15,25-26,30H,8-9,11-14,16-20H2,1-2H3,(H,37,41,42) YFDWSRKLFFCZRD-UHFFFAOYSA-N 531851 3-(5-((8-(4'-chloro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-carbonyl)-3,8- diazabicyclo[3.2.1]octan-3-yl)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05523 Protein cereblon Homo sapiens 860 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531851 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531851&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440554 463795289 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237911 CC6(C)CCC(CN4CCN(Cc3ccc2C(=O)N(C1CCC(=O)NC1=O)Cc2c3)C(C(F)(F)F)C4)=C(c5ccc(Cl)cc5)C6 InChI=1S/C34H41ClN4O3/c1-22-18-37(20-25-12-13-34(2,3)17-29(25)24-5-7-27(35)8-6-24)14-15-38(22)19-23-4-9-28-26(16-23)21-39(33(28)42)30-10-11-31(40)36-32(30)41/h4-9,16,22,30H,10-15,17-21H2,1-3H3,(H,36,40,41) ULXYKBZAWHESKT-UHFFFAOYSA-N 531852 3-(5-((4-((4'-chloro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-yl)methyl)-2- (trifluoromethyl)piperazin-1-yl)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05796 Protein cereblon Homo sapiens 200 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531852 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531852&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440591 463795290 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237912 CC1(C)CCC(CN2CC3CC(C2)N3Cc2cc(F)c3c(c2)CN(C2CCC(=O)NC2=O)C3=O)=C(c2ccc(Cl)cc2)C1 InChI=1S/C34H38ClFN4O3/c1-34(2)10-9-22(27(14-34)21-3-5-24(35)6-4-21)16-38-18-25-13-26(19-38)39(25)15-20-11-23-17-40(33(43)31(23)28(36)12-20)29-7-8-30(41)37-32(29)42/h3-6,11-12,25-26,29H,7-10,13-19H2,1-2H3,(H,37,41,42) RNZPARGRALRHKT-UHFFFAOYSA-N 531853 3-(5-((3-((4'-chloro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-yl)methyl)- 3,6-diazabicyclo[3.1.1]heptan-6- yl)methyl)-7-fluoro-1-oxoisoindolin-2- yl)piperidine-2,6-dione::US20260028326, Compound GT-05383 Protein cereblon Homo sapiens 540 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531853 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531853&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 142754131 463795291 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237913 CC1(C)CCC(C(=O)N2CC3CC2CN3Cc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)=C(c2ccc(Cl)cc2)C1 InChI=1S/C34H37ClN4O4/c1-34(2)12-11-27(28(15-34)21-4-6-23(35)7-5-21)33(43)38-19-24-14-25(38)18-37(24)16-20-3-8-26-22(13-20)17-39(32(26)42)29-9-10-30(40)36-31(29)41/h3-8,13,24-25,29H,9-12,14-19H2,1-2H3,(H,36,40,41) SRXMWKAWXQTGOR-UHFFFAOYSA-N 531854 3-(5-((5-(4'-chloro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-carbonyl)-2,5- diazabicyclo[2.2.1]heptan-2-yl)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05524 Protein cereblon Homo sapiens 490 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531854 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531854&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 142754048 463795292 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237914 CC6(C)CCC(C(=O)N4CCN(Cc3ccc2C(=O)N(C1CCC(=O)NC1=O)Cc2c3)C(C(F)(F)F)C4)=C(c5ccc(Cl)cc5)C6 InChI=1S/C34H39ClN4O4/c1-21-18-38(32(42)27-12-13-34(2,3)17-28(27)23-5-7-25(35)8-6-23)15-14-37(21)19-22-4-9-26-24(16-22)20-39(33(26)43)29-10-11-30(40)36-31(29)41/h4-9,16,21,29H,10-15,17-20H2,1-3H3,(H,36,40,41) WLFNWTLHZLGJTC-UHFFFAOYSA-N 531855 3-(5-((4-(4'-chloro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-carbonyl)-2- (trifluoromethyl)piperazin-1-yl)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05845 Protein cereblon Homo sapiens 760 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531855 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531855&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 142754034 463795293 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237915 CC1(C)CCC(CN2CC3CC(C2)N3c2ccc3c(c2)C(=O)N(C2CCC(=O)NC2=O)C3=O)=C(c2ccc(F)cc2)C1 InChI=1S/C33H35FN4O4/c1-33(2)12-11-20(27(15-33)19-3-5-21(34)6-4-19)16-36-17-23-13-24(18-36)37(23)22-7-8-25-26(14-22)32(42)38(31(25)41)28-9-10-29(39)35-30(28)40/h3-8,14,23-24,28H,9-13,15-18H2,1-2H3,(H,35,39,40) UKGJCFZFSSWMMI-UHFFFAOYSA-N 531856 2-(2,6-dioxopiperidin-3-yl)-5-(3-((4'- fluoro-5,5-dimethyl-3,4,5,6-tetrahydro- [1,1'-biphenyl]-2-yl)methyl)-3,6- diazabicyclo[3.1.1]heptan-6-yl)isoindoline- 1,3-dione::US20260028326, Compound GT-05386 Protein cereblon Homo sapiens 1460 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531856 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531856&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 142754066 463795294 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237916 CC1(C)CCC(C(=O)N2CCN(Cc3ccc4c(c3F)CN(C3CCC(=O)NC3=O)C4=O)CC2)=C(c2ccc(Cl)cc2)C1 InChI=1S/C33H36ClFN4O4/c1-33(2)12-11-24(25(17-33)20-3-6-22(34)7-4-20)31(42)38-15-13-37(14-16-38)18-21-5-8-23-26(29(21)35)19-39(32(23)43)27-9-10-28(40)36-30(27)41/h3-8,27H,9-19H2,1-2H3,(H,36,40,41) RFDPIUJQOYQZNZ-UHFFFAOYSA-N 531857 3-(5-((4-(4'-chloro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2- carbonyl)piperazin-1-yl)methyl)-4-fluoro- 1-oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05525 Protein cereblon Homo sapiens 710 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531857 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531857&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 142754169 463795295 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237917 CC6(C)CCC(C(=O)N4CCN(Cc3ccc2C(=O)N(C1CCC(=O)NC1=O)Cc2c3)C(C(F)(F)F)C4)=C(c5ccc(F)cc5)C6 InChI=1S/C34H39FN4O4/c1-21-18-38(32(42)27-12-13-34(2,3)17-28(27)23-5-7-25(35)8-6-23)15-14-37(21)19-22-4-9-26-24(16-22)20-39(33(26)43)29-10-11-30(40)36-31(29)41/h4-9,16,21,29H,10-15,17-20H2,1-3H3,(H,36,40,41) RGSBTZPTYDSQEC-UHFFFAOYSA-N 531858 3-(5-((4-((4'-fluoro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-yl)methyl)-2- (trifluoromethyl)piperazin-1-yl)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05846 Protein cereblon Homo sapiens 940 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531858 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531858&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 142754155 463795296 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237918 CC1(C)CCC(CN2C3CC2CN(c2ccc4c(c2)C(=O)N(C2CCC(=O)NC2=O)C4=O)C3)=C(c2ccc(F)cc2)C1 InChI=1S/C33H35FN4O4/c1-33(2)12-11-20(27(15-33)19-3-5-21(34)6-4-19)16-37-23-13-24(37)18-36(17-23)22-7-8-25-26(14-22)32(42)38(31(25)41)28-9-10-29(39)35-30(28)40/h3-8,14,23-24,28H,9-13,15-18H2,1-2H3,(H,35,39,40) VXHFFARUIAZXRZ-UHFFFAOYSA-N 531859 2-(2,6-dioxopiperidin-3-yl)-5-(6-((4'- fluoro-5,5-dimethyl-3,4,5,6-tetrahydro- [1,1'-biphenyl]-2-yl)methyl)-3,6- diazabicyclo[3.1.1]heptan-3-yl)isoindoline- 1,3-dione::US20260028326, Compound GT-05387 Protein cereblon Homo sapiens 810 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531859 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531859&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 142754094 463795297 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237919 CC1(C)CCC(C(=O)N2CCN(Cc3cc4c(cc3F)C(=O)N(C3CCC(=O)NC3=O)C4)CC2)=C(c2ccc(Cl)cc2)C1 InChI=1S/C33H36ClFN4O4/c1-33(2)10-9-24(26(17-33)20-3-5-23(34)6-4-20)31(42)38-13-11-37(12-14-38)18-22-15-21-19-39(32(43)25(21)16-27(22)35)28-7-8-29(40)36-30(28)41/h3-6,15-16,28H,7-14,17-19H2,1-2H3,(H,36,40,41) DBDBGEBJZWBVLB-UHFFFAOYSA-N 531860 3-(5-((4-(4'-chloro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2- carbonyl)piperazin-1-yl)methyl)-6-fluoro- 1-oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05526 Protein cereblon Homo sapiens 690 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531860 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531860&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440216 463795298 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237920 CC1(C)CCC(CN2CCC(Cc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)CC2)=C(c2cccs2)C1 InChI=1S/C32H39N3O3S/c1-32(2)12-9-23(26(18-32)28-4-3-15-39-28)19-34-13-10-21(11-14-34)16-22-5-6-25-24(17-22)20-35(31(25)38)27-7-8-29(36)33-30(27)37/h3-6,15,17,21,27H,7-14,16,18-20H2,1-2H3,(H,33,36,37) ADPMMYTWKIZDEY-UHFFFAOYSA-N 531861 3-(5-((4-((4,4-dimethyl-2-(thiophen-2- yl)cyclohex-1-en-1-yl)methyl)piperazin-1- yl)methyl)-1-oxoisoindolin-2-yl)piperidine- 2,6-dione::US20260028326, Compound GT-05847 Protein cereblon Homo sapiens 1000 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531861 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531861&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 142754158 463795299 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237921 CC1(C)CCC(CN2CC3CCC2CN3c2ccc3c(c2)C(=O)N(C2CCC(=O)NC2=O)C3=O)=C(c2ccc(F)cc2)C1 InChI=1S/C34H37FN4O4/c1-34(2)14-13-21(28(16-34)20-3-5-22(35)6-4-20)17-37-18-25-8-7-24(37)19-38(25)23-9-10-26-27(15-23)33(43)39(32(26)42)29-11-12-30(40)36-31(29)41/h3-6,9-10,15,24-25,29H,7-8,11-14,16-19H2,1-2H3,(H,36,40,41) CUEAAWBVEANTTF-UHFFFAOYSA-N 531864 2-(2,6-dioxopiperidin-3-yl)-5-(5-((4'- fluoro-5,5-dimethyl-3,4,5,6-tetrahydro- [1,1'-biphenyl]-2-yl)methyl)-2,5- diazabicyclo[2.2.2]octan-2-yl)isoindoline- 1,3-dione::US20260028326, Compound GT-05388 Protein cereblon Homo sapiens 410 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531864 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531864&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 142754161 463795300 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237922 CC1(C)CCC(C(=O)N2CCN(Cc3cc(F)c4c(c3)CN(C3CCC(=O)NC3=O)C4=O)CC2)=C(c2ccc(Cl)cc2)C1 InChI=1S/C33H36ClFN4O4/c1-33(2)10-9-24(25(17-33)21-3-5-23(34)6-4-21)31(42)38-13-11-37(12-14-38)18-20-15-22-19-39(32(43)29(22)26(35)16-20)27-7-8-28(40)36-30(27)41/h3-6,15-16,27H,7-14,17-19H2,1-2H3,(H,36,40,41) SQWRQVCHHUQEDB-UHFFFAOYSA-N 531865 3-(5-((4-(4'-chloro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2- carbonyl)piperazin-1-yl)methyl)-7-fluoro- 1-oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05527 Protein cereblon Homo sapiens 990 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531865 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531865&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 142754141 463795301 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237923 CC1(C)CCC(CN2CCN(Cc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)CC2)=C(c2cnco2)C1 InChI=1S/C30H37N5O4/c1-30(2)8-7-21(24(14-30)26-15-31-19-39-26)17-34-11-9-33(10-12-34)16-20-3-4-23-22(13-20)18-35(29(23)38)25-5-6-27(36)32-28(25)37/h3-4,13,15,19,25H,5-12,14,16-18H2,1-2H3,(H,32,36,37) UYEYZIZNGASAAE-UHFFFAOYSA-N 531866 3-(5-((4-((4,4-dimethyl-2-(oxazol-5- yl)cyclohex-1-en-1-yl)methyl)piperazin-1- yl)methyl)-1-oxoisoindolin-2-yl)piperidine- 2,6-dione::US20260028326, Compound GT-05848 Protein cereblon Homo sapiens 710 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531866 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531866&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 142754036 463795302 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237924 CC1(C)CCC(CN2CCN(Cc3ccc4c(c3F)CN(C3CCC(=O)NC3=O)C4=O)CC2)=C(c2ccc(F)cc2)C1 InChI=1S/C33H38F2N4O3/c1-33(2)12-11-22(26(17-33)21-3-6-24(34)7-4-21)18-37-13-15-38(16-14-37)19-23-5-8-25-27(30(23)35)20-39(32(25)42)28-9-10-29(40)36-31(28)41/h3-8,28H,9-20H2,1-2H3,(H,36,40,41) QKOKBBDTNVTYEZ-UHFFFAOYSA-N 531867 3-(4-fluoro-5-((4-((4'-fluoro-5,5-dimethyl- 3,4,5,6-tetrahydro-[1,1'biphenyl]-2- yl)methyl)piperazin-1-yl)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05390 Protein cereblon Homo sapiens 500 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531867 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531867&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440592 463795303 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237925 CC1(C)CCC(C(=O)N2CCN(Cc3cccc4c3CN(C3CCC(=O)NC3=O)C4=O)CC2)=C(c2ccc(Cl)cc2)C1 InChI=1S/C33H37ClN4O4/c1-33(2)13-12-25(26(18-33)21-6-8-23(34)9-7-21)31(41)37-16-14-36(15-17-37)19-22-4-3-5-24-27(22)20-38(32(24)42)28-10-11-29(39)35-30(28)40/h3-9,28H,10-20H2,1-2H3,(H,35,39,40) AOUMQDCPHBCYMB-UHFFFAOYSA-N 531868 3-(4-((4-(4'-chloro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2- carbonyl)piperazin-1-yl)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05528 Protein cereblon Homo sapiens 1930 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531868 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531868&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440276 463795304 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237926 O=C1CCC(N2Cc3cc(CN4CCN(Cc5ccccc5-c5cnco5)CC4)ccc3C2=O)C(=O)N1 InChI=1S/C28H29N5O4/c34-26-8-7-24(27(35)30-26)33-17-21-13-19(5-6-23(21)28(33)36)15-31-9-11-32(12-10-31)16-20-3-1-2-4-22(20)25-14-29-18-37-25/h1-6,13-14,18,24H,7-12,15-17H2,(H,30,34,35) DGCHNXTZTGPPQQ-UHFFFAOYSA-N 531869 3-(5-((4-(2-(oxazol-5-yl)benzyl)piperazin- 1-yl)methyl)-1-oxoisoindolin-2- yl)piperidine-2,6-dione::US20260028326, Compound GT-05849 Protein cereblon Homo sapiens 990 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531869 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531869&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440039 463795305 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237927 CC1(C)CCC(CN2CCN(Cc3cc4c(cc3F)C(=O)N(C3CCC(=O)NC3=O)C4)CC2)=C(c2ccc(F)cc2)C1 InChI=1S/C33H38F2N4O3/c1-33(2)10-9-22(27(17-33)21-3-5-25(34)6-4-21)18-37-11-13-38(14-12-37)19-24-15-23-20-39(32(42)26(23)16-28(24)35)29-7-8-30(40)36-31(29)41/h3-6,15-16,29H,7-14,17-20H2,1-2H3,(H,36,40,41) IUJCSEFHXWCHFH-UHFFFAOYSA-N 531870 3-(6-fluoro-5-((4-((4'-fluoro-5,5-dimethyl- 3,4,5,6-tetrahydro-[1,1'-biphenyl]-2- yl)methyl)piperazin-1-yl)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05391 Protein cereblon Homo sapiens 570 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531870 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531870&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440901 463795306 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237928 CC1(C)CCC(CN2C3CC2CN(Cc2ccc4c(c2F)CN(C2CCC(=O)NC2=O)C4=O)C3)=C(c2ccc(Cl)cc2)C1 InChI=1S/C34H38ClFN4O3/c1-34(2)12-11-21(27(14-34)20-3-6-23(35)7-4-20)16-39-24-13-25(39)18-38(17-24)15-22-5-8-26-28(31(22)36)19-40(33(26)43)29-9-10-30(41)37-32(29)42/h3-8,24-25,29H,9-19H2,1-2H3,(H,37,41,42) WTKVLBMBLMEIME-UHFFFAOYSA-N 531871 3-(5-((6-((4'-chloro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-yl)methyl)- 3,6-diazabicyclo[3.1.1]heptan-3- yl)methyl)-4-fluoro-1-oxoisoindolin-2- yl)piperidine-2,6-dione::US20260028326, Compound GT-05529 Protein cereblon Homo sapiens 350 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531871 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531871&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 142754128 463795307 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237929 CC1(C)CCC(C(=O)N2CC3(CN(Cc4ccc5c(c4)CN(C4CCC(=O)NC4=O)C5=O)C3)C2)=C(c2ccc(F)cc2)C1 InChI=1S/C34H37FN4O4/c1-33(2)12-11-26(27(14-33)22-4-6-24(35)7-5-22)31(42)38-19-34(20-38)17-37(18-34)15-21-3-8-25-23(13-21)16-39(32(25)43)28-9-10-29(40)36-30(28)41/h3-8,13,28H,9-12,14-20H2,1-2H3,(H,36,40,41) XJHCIAFGAFIUPK-UHFFFAOYSA-N 531872 3-(5-((6-((4'-fluoro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-yl)methyl)- 2,6-diazaspiro[3.3]heptan-2-yl)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05670 Protein cereblon Homo sapiens 620 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531872 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531872&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 142754070 463795308 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237930 CC1(C)CCC(CN2CCN(Cc3cc(F)c4c(c3)CN(C3CCC(=O)NC3=O)C4=O)CC2)=C(c2ccc(F)cc2)C1 InChI=1S/C33H38F2N4O3/c1-33(2)10-9-23(26(17-33)22-3-5-25(34)6-4-22)19-38-13-11-37(12-14-38)18-21-15-24-20-39(32(42)30(24)27(35)16-21)28-7-8-29(40)36-31(28)41/h3-6,15-16,28H,7-14,17-20H2,1-2H3,(H,36,40,41) IZMGBMRYCDIYGU-UHFFFAOYSA-N 531873 3-(7-fluoro-5-((4-((4'-fluoro-5,5-dimethyl- 3,4,5,6-tetrahydro-[1,1'-biphenyl]-2- yl)methyl)piperazin-1-yl)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05392 Protein cereblon Homo sapiens 440 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531873 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531873&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440810 463795309 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237931 CC1(C)CCC(CN2C3CC2CN(C(=O)c2cc4c(cc2F)C(=O)N(C2CCC(=O)NC2=O)C4)C3)=C(c2ccc(Cl)cc2)C1 InChI=1S/C34H36ClFN4O4/c1-34(2)10-9-20(27(14-34)19-3-5-22(35)6-4-19)15-39-23-12-24(39)18-38(17-23)32(43)26-11-21-16-40(33(44)25(21)13-28(26)36)29-7-8-30(41)37-31(29)42/h3-6,11,13,23-24,29H,7-10,12,14-18H2,1-2H3,(H,37,41,42) QJIXMDQJGCXBDQ-UHFFFAOYSA-N 531874 3-(5-((6-((4'-chloro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-yl)methyl)- 3,6-diazabicyclo[3.1.1]heptan-3- yl)methyl)-6-fluoro-1-oxoisoindolin-2- yl)piperidine-2,6-dione::US20260028326, Compound GT-05530 Protein cereblon Homo sapiens 1200 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531874 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531874&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 142754142 463795310 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237932 CC1(C)CCC(CN2C3CC2CN(C(=O)c2ccc4c(c2)CN(C2CCC(=O)NC2=O)C4=O)C3)=C(c2ccc(F)cc2)C1 InChI=1S/C34H37FN4O4/c1-34(2)12-11-22(28(15-34)20-3-6-24(35)7-4-20)16-38-25-14-26(38)19-37(18-25)32(42)21-5-8-27-23(13-21)17-39(33(27)43)29-9-10-30(40)36-31(29)41/h3-8,13,25-26,29H,9-12,14-19H2,1-2H3,(H,36,40,41) OCQGLOMKMHMDLU-UHFFFAOYSA-N 531875 3-(5-(6-((4'-fluoro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-yl)methyl)- 3,6-diazabicyclo[3.3.1]heptane-3- carbonyl)-1-oxoisoindolin-2-yl)piperidine- 2,6-dione::US20260028326, Compound GT-05671 Protein cereblon Homo sapiens 300 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531875 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531875&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440593 463795311 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237933 CC1(C)CCC(CN2CCN(Cc3cccc4c3CN(C3CCC(=O)NC3=O)C4=O)CC2)=C(c2ccc(F)cc2)C1 InChI=1S/C33H39FN4O3/c1-33(2)13-12-24(27(18-33)22-6-8-25(34)9-7-22)20-37-16-14-36(15-17-37)19-23-4-3-5-26-28(23)21-38(32(26)41)29-10-11-30(39)35-31(29)40/h3-9,29H,10-21H2,1-2H3,(H,35,39,40) ADKGCMDIJVGVGQ-UHFFFAOYSA-N 531876 3-(4-((4-((4'-fluoro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2- yl)methyl)piperazin-1-yl)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05393 Protein cereblon Homo sapiens 340 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531876 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531876&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440197 463795312 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237934 CC1(C)CCC(CN2C3CC2CN(Cc2cc(F)c4c(c2)CN(C2CCC(=O)NC2=O)C4=O)C3)=C(c2ccc(Cl)cc2)C1 InChI=1S/C34H38ClFN4O3/c1-34(2)10-9-22(27(14-34)21-3-5-24(35)6-4-21)16-39-25-13-26(39)19-38(18-25)15-20-11-23-17-40(33(43)31(23)28(36)12-20)29-7-8-30(41)37-32(29)42/h3-6,11-12,25-26,29H,7-10,13-19H2,1-2H3,(H,37,41,42) FBLIUHYWBBMOLL-UHFFFAOYSA-N 531877 3-(5-((6-((4'-chloro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-yl)methyl)- 3,6-diazabicyclo[3.1.1]heptan-3- yl)methyl)-7-fluoro-1-oxoisoindolin-2- yl)piperidine-2,6-dione::US20260028326, Compound GT-05531 Protein cereblon Homo sapiens 800 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531877 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531877&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440811 463795313 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237935 CC1(C)CCC(CN2CC3CN(Cc4ccc5c(c4)CN(C4CCC(=O)NC4=O)C5=O)CC3C2)=C(c2ccc(Cl)cc2)C1 InChI=1S/C35H41ClN4O3/c1-35(2)12-11-24(30(14-35)23-4-6-28(36)7-5-23)16-39-19-26-17-38(18-27(26)20-39)15-22-3-8-29-25(13-22)21-40(34(29)43)31-9-10-32(41)37-33(31)42/h3-8,13,26-27,31H,9-12,14-21H2,1-2H3,(H,37,41,42) FNZDKTUXYHWKHB-UHFFFAOYSA-N 531878 3-(5-((5-((4'-chloro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2- yl)methyl)hexahydropyrrolo[3,4-c]pyrrol- 2(1H)-yl)methyl)-1-oxoisoindolin-2- yl)piperidine-2,6-dione::US20260028326, Compound GT-05653 Protein cereblon Homo sapiens 1060 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531878 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531878&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440796 463795314 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237936 CC1(C)CCC(CN2CCN(Cc3ccc4c(c3)C(=O)N(C3CCC(=O)NC3=O)C4)CC2)=C(c2ccc(F)cc2)C1 InChI=1S/C33H39FN4O3/c1-33(2)12-11-25(28(18-33)23-5-7-26(34)8-6-23)20-37-15-13-36(14-16-37)19-22-3-4-24-21-38(32(41)27(24)17-22)29-9-10-30(39)35-31(29)40/h3-8,17,29H,9-16,18-21H2,1-2H3,(H,35,39,40) DJNPNYXSNVFNSN-UHFFFAOYSA-N 531879 3-(6-((4-((4'-fluoro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2- yl)methyl)piperazin-1-yl)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05394 Protein cereblon Homo sapiens 490 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531879 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531879&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 146370662 463795315 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237937 CC1(C)CCC(CN2C3CCC2CN(Cc2ccc4c(c2F)CN(C2CCC(=O)NC2=O)C4=O)C3)=C(c2ccc(Cl)cc2)C1 InChI=1S/C35H40ClFN4O3/c1-35(2)14-13-22(28(15-35)21-3-6-24(36)7-4-21)17-40-25-8-9-26(40)19-39(18-25)16-23-5-10-27-29(32(23)37)20-41(34(27)44)30-11-12-31(42)38-33(30)43/h3-7,10,25-26,30H,8-9,11-20H2,1-2H3,(H,38,42,43) HCWIZXVVSFATHP-UHFFFAOYSA-N 531882 3-(5-((8-((4'-chloro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-yl)methyl)- 3,8-diazabicyclo[3.2.1]octan-3-yl)methyl)- 4-fluoro-1-oxoisoindolin-2-yl)piperidine- 2,6-dione::US20260028326, Compound GT-05534 Protein cereblon Homo sapiens 1170 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531882 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531882&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 146396532 463795316 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237938 CC1(C)CCC(C(=O)N2CCC3(CC2)CN(Cc2ccc4c(c2)CN(C2CCC(=O)NC2=O)C4=O)C3)=C(c2ccc(Cl)cc2)C1 InChI=1S/C36H41ClN4O4/c1-35(2)12-11-28(29(18-35)24-4-6-26(37)7-5-24)33(44)40-15-13-36(14-16-40)21-39(22-36)19-23-3-8-27-25(17-23)20-41(34(27)45)30-9-10-31(42)38-32(30)43/h3-8,17,30H,9-16,18-22H2,1-2H3,(H,38,42,43) SQBGMALMMZAMMN-UHFFFAOYSA-N 531883 3-(5-((7-(4'-chloro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-carbonyl)-2,7- diazaspiro[3.5]nonan-2-yl)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05656 Protein cereblon Homo sapiens 700 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531883 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531883&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 142754082 463795317 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237939 CC1(C)CCC(CN2CCN(Cc3ccc4c(c3)C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)=C(c2ccc(F)cc2)C1 InChI=1S/C33H37FN4O4/c1-33(2)12-11-23(27(18-33)22-4-6-24(34)7-5-22)20-37-15-13-36(14-16-37)19-21-3-8-25-26(17-21)32(42)38(31(25)41)28-9-10-29(39)35-30(28)40/h3-8,17,28H,9-16,18-20H2,1-2H3,(H,35,39,40) JNKMTGPYHXUYHD-UHFFFAOYSA-N 531884 2-(2,6-dioxopiperidin-3-yl)-5-((4-((4'- fluoro-5,5-dimethyl-3,4,5,6-tetrahydro- [1,1'-biphenyl]-2-yl)methyl)piperazin-1- yl)methyl)isoindoline-1,3-dione::US20260028326, Compound GT-05395 Protein cereblon Homo sapiens 1610 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531884 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531884&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440303 463795318 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237940 CC1(C)CCC(CN2C3CCC2CN(C(=O)c2cc4c(cc2F)C(=O)N(C2CCC(=O)NC2=O)C4)C3)=C(c2ccc(Cl)cc2)C1 InChI=1S/C35H38ClFN4O4/c1-35(2)12-11-21(28(15-35)20-3-5-23(36)6-4-20)16-40-24-7-8-25(40)19-39(18-24)33(44)27-13-22-17-41(34(45)26(22)14-29(27)37)30-9-10-31(42)38-32(30)43/h3-6,13-14,24-25,30H,7-12,15-19H2,1-2H3,(H,38,42,43) ZYNZZCUQZMOGBK-UHFFFAOYSA-N 531885 3-(5-((8-((4'-chloro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-yl)methyl)- 3,8-diazabicyclo[3.2.1]octan-3-yl)methyl)- 6-fluoro-1-oxoisoindolin-2-yl)piperidine- 2,6-dione::US20260028326, Compound GT-05535 Protein cereblon Homo sapiens 1790 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531885 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531885&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 142754084 463795319 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237941 CC1(C)CCC(C(=O)N2CCC3(CC2)CN(C(=O)c2ccc4c(c2)CN(C2CCC(=O)NC2=O)C4=O)C3)=C(c2ccc(Cl)cc2)C1 InChI=1S/C36H39ClN4O5/c1-35(2)12-11-27(28(18-35)22-3-6-25(37)7-4-22)33(45)39-15-13-36(14-16-39)20-40(21-36)32(44)23-5-8-26-24(17-23)19-41(34(26)46)29-9-10-30(42)38-31(29)43/h3-8,17,29H,9-16,18-21H2,1-2H3,(H,38,42,43) OFQVYOANEIOFMJ-UHFFFAOYSA-N 531886 3-(5-(7-(4'-chloro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-carbonyl)-2,7- diazaspiro[3.5]nonane-2-carbonyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05657 Protein cereblon Homo sapiens 1170 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531886 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531886&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 142754053 463795320 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237942 CC1(C)CCC(CN2CCCN(Cc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)CC2)=C(c2ccc(Cl)cc2)C1 InChI=1S/C34H41ClN4O3/c1-34(2)13-12-25(29(19-34)24-5-7-27(35)8-6-24)21-38-15-3-14-37(16-17-38)20-23-4-9-28-26(18-23)22-39(33(28)42)30-10-11-31(40)36-32(30)41/h4-9,18,30H,3,10-17,19-22H2,1-2H3,(H,36,40,41) PQUOQIXRDUCIJY-UHFFFAOYSA-N 531887 3-(5-((4-((4'-chloro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-yl)methyl)- 1,4-diazepan-1-yl)methyl)-1-oxoisoindolin- 2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05396 Protein cereblon Homo sapiens 590 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531887 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531887&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440508 463795321 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237943 CC1(C)CCC(CN2C3CCC2CN(Cc2cc(F)c4c(c2)CN(C2CCC(=O)NC2=O)C4=O)C3)=C(c2ccc(Cl)cc2)C1 InChI=1S/C35H40ClFN4O3/c1-35(2)12-11-23(28(15-35)22-3-5-25(36)6-4-22)17-40-26-7-8-27(40)20-39(19-26)16-21-13-24-18-41(34(44)32(24)29(37)14-21)30-9-10-31(42)38-33(30)43/h3-6,13-14,26-27,30H,7-12,15-20H2,1-2H3,(H,38,42,43) YFFOSRAXPUORRE-UHFFFAOYSA-N 531888 3-(5-((8-((4'-chloro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-yl)methyl)- 3,8-diazabicyclo[3.2.1]octan-3-yl)methyl)- 7-fluoro-1-oxoisoindolin-2-yl)piperidine- 2,6-dione::US20260028326, Compound GT-05536 Protein cereblon Homo sapiens 1050 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531888 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531888&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440900 463795322 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237944 CC1(C)CCC(C(=O)N2CC3CN(Cc4ccc5c(c4)CN(C4CCC(=O)NC4=O)C5=O)CC3C2)=C(c2ccc(Cl)cc2)C1 InChI=1S/C35H39ClN4O4/c1-35(2)12-11-28(29(14-35)22-4-6-26(36)7-5-22)33(43)39-18-24-16-38(17-25(24)19-39)15-21-3-8-27-23(13-21)20-40(34(27)44)30-9-10-31(41)37-32(30)42/h3-8,13,24-25,30H,9-12,14-20H2,1-2H3,(H,37,41,42) RLJCXAXVKXFVAC-UHFFFAOYSA-N 531889 3-(5-((5-(4'-chloro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2- carbonyl)hexahydropyrrolo[3,4-c]pyrrol- 2(1H)-yl)methyl)-1-oxoisoindolin-2- yl)piperidine-2,6-dione::US20260028326, Compound GT-05658 Protein cereblon Homo sapiens 740 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531889 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531889&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 142754100 463795323 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237945 CC1(C)CCC(C(=O)N2CC3CN(Cc4ccc5c(c4)CN(C4CCC(=O)NC4=O)C5=O)CC3C2)=C(c2ccc(F)cc2)C1 InChI=1S/C35H39FN4O4/c1-35(2)12-11-28(29(14-35)22-4-6-26(36)7-5-22)33(43)39-18-24-16-38(17-25(24)19-39)15-21-3-8-27-23(13-21)20-40(34(27)44)30-9-10-31(41)37-32(30)42/h3-8,13,24-25,30H,9-12,14-20H2,1-2H3,(H,37,41,42) BRYIOQAWPZPVCH-UHFFFAOYSA-N 531890 3-(5-((5-((4'-fluoro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-bphenyl]-2- yl)methyl)hexahydropyrrolo[3,4-c]pyrrol- 2(1H)-yl)methyl)-1-oxoisoindolin-2- yl)piperidine-2,6-dione::US20260028326, Compound GT-05398 Protein cereblon Homo sapiens 1050 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531890 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531890&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 142754099 463795324 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237946 CC1(C)CCC(C(=O)N2CC3CC(C2)N3C(=O)c2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)=C(c2ccc(Cl)cc2)C1 InChI=1S/C34H35ClN4O5/c1-34(2)12-11-26(27(15-34)19-3-6-22(35)7-4-19)32(43)37-17-23-14-24(18-37)39(23)31(42)20-5-8-25-21(13-20)16-38(33(25)44)28-9-10-29(40)36-30(28)41/h3-8,13,23-24,28H,9-12,14-18H2,1-2H3,(H,36,40,41) IVBKQTNAMKDXMW-UHFFFAOYSA-N 531891 3-(5-(3-(4'-chloro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-carbonyl)-3,6- diazabicyclo[3.1.1]heptane-6-carbonyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05538 Protein cereblon Homo sapiens 1020 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531891 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531891&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 142754052 463795325 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237947 CC1(C)CCC(C(=O)N2CC3CN(C(=O)c4ccc5c(c4)CN(C4CCC(=O)NC4=O)C5=O)CC3C2)=C(c2ccc(Cl)cc2)C1 InChI=1S/C35H37ClN4O5/c1-35(2)12-11-27(28(14-35)20-3-6-25(36)7-4-20)33(44)39-17-23-15-38(16-24(23)18-39)32(43)21-5-8-26-22(13-21)19-40(34(26)45)29-9-10-30(41)37-31(29)42/h3-8,13,23-24,29H,9-12,14-19H2,1-2H3,(H,37,41,42) SNDUNSOVYYKCFQ-UHFFFAOYSA-N 531892 3-(5-(5-(4'-chloro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2- carbonyl)octahydropyrrolo[3,4-c]pyrrole-2- carbonyl)-1-oxoisoindolin-2-yl)piperidine- 2,6-dione::US20260028326, Compound GT-05659 Protein cereblon Homo sapiens 660 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531892 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531892&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 142754133 463795326 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237948 CC1(C)CCC(CN2CC3CC(C2)N3Cc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)=C(c2ccc(F)cc2)C1 InChI=1S/C34H39FN4O3/c1-34(2)12-11-23(29(15-34)22-4-6-25(35)7-5-22)17-37-19-26-14-27(20-37)38(26)16-21-3-8-28-24(13-21)18-39(33(28)42)30-9-10-31(40)36-32(30)41/h3-8,13,26-27,30H,9-12,14-20H2,1-2H3,(H,36,40,41) AFALFUHOTRDVAE-UHFFFAOYSA-N 531893 3-(5-((3-((4'-fluoro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-yl)methyl)- 3,6-diazabicyclo[3.1.1]heptan-6- yl)methyl)-1-oxoisoindolin-2-yl)piperidine- 2,6-dione::US20260028326, Compound GT-05399 Protein cereblon Homo sapiens 430 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531893 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531893&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 142754037 463795327 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237949 CC1(C)CCC(C(=O)N2CC3CCC(C2)N3C(=O)c2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)=C(c2ccc(Cl)cc2)C1 InChI=1S/C35H37ClN4O5/c1-35(2)14-13-27(28(16-35)20-3-6-23(36)7-4-20)33(44)38-18-24-8-9-25(19-38)40(24)32(43)21-5-10-26-22(15-21)17-39(34(26)45)29-11-12-30(41)37-31(29)42/h3-7,10,15,24-25,29H,8-9,11-14,16-19H2,1-2H3,(H,37,41,42) MQLGLUVSOGUPAN-UHFFFAOYSA-N 531894 3-(5-(3-(4'-chloro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-carbonyl)-3,8- diazabicyclo[3.2.1]octane-8-carbonyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05539 Protein cereblon Homo sapiens 1280 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531894 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531894&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440902 463795328 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237950 CC1(C)CCC(C(=O)N2C3CC2CN(Cc2ccc4c(c2)CN(C2CCC(=O)NC2=O)C4=O)C3)=C(c2ccc(Cl)cc2)C1 InChI=1S/C34H37ClN4O4/c1-34(2)12-11-27(28(15-34)21-4-6-23(35)7-5-21)33(43)39-24-14-25(39)19-37(18-24)16-20-3-8-26-22(13-20)17-38(32(26)42)29-9-10-30(40)36-31(29)41/h3-8,13,24-25,29H,9-12,14-19H2,1-2H3,(H,36,40,41) KLXJXXDARJWSCZ-UHFFFAOYSA-N 531895 3-(5-((6-(4'-chloro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-carbonyl)-3,6- diazabicyclo[3.1.1]heptan-3-yl)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05660 Protein cereblon Homo sapiens 1040 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531895 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531895&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 142754164 463795329 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237951 CC1(C)CCC(CN2CC3CCC(C2)N3Cc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)=C(c2ccc(F)cc2)C1 InChI=1S/C35H41FN4O3/c1-35(2)14-13-24(30(16-35)23-4-6-26(36)7-5-23)18-38-20-27-8-9-28(21-38)39(27)17-22-3-10-29-25(15-22)19-40(34(29)43)31-11-12-32(41)37-33(31)42/h3-7,10,15,27-28,31H,8-9,11-14,16-21H2,1-2H3,(H,37,41,42) ONMCRXMSQHHCLJ-UHFFFAOYSA-N 531896 3-(5-((3-((4'-fluoro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-yl)methyl)- 3,8-diazabicyclo[3.2.1]octan-8-yl)methyl)- 1-oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05400 Protein cereblon Homo sapiens 840 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531896 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531896&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 142754117 463795330 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237952 CC1(C)CCC(C(=O)N2C3CCC2CN(C(=O)c2ccc4c(c2)CN(C2CCC(=O)NC2=O)C4=O)C3)=C(c2ccc(Cl)cc2)C1 InChI=1S/C35H37ClN4O5/c1-35(2)14-13-27(28(16-35)20-3-6-23(36)7-4-20)34(45)40-24-8-9-25(40)19-38(18-24)32(43)21-5-10-26-22(15-21)17-39(33(26)44)29-11-12-30(41)37-31(29)42/h3-7,10,15,24-25,29H,8-9,11-14,16-19H2,1-2H3,(H,37,41,42) QHUZCFWBZISTAE-UHFFFAOYSA-N 531897 3-(5-(8-(4'-chloro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-carbonyl)-3,8- diazabicyclo[3.2.1]octane-3-carbonyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05540 Protein cereblon Homo sapiens 960 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531897 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531897&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440228 463795331 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237953 CC1(C)CCC(C(=O)N2C3CC2CN(C(=O)c2ccc4c(c2)CN(C2CCC(=O)NC2=O)C4=O)C3)=C(c2ccc(Cl)cc2)C1 InChI=1S/C34H35ClN4O5/c1-34(2)12-11-26(27(15-34)19-3-6-22(35)7-4-19)33(44)39-23-14-24(39)18-37(17-23)31(42)20-5-8-25-21(13-20)16-38(32(25)43)28-9-10-29(40)36-30(28)41/h3-8,13,23-24,28H,9-12,14-18H2,1-2H3,(H,36,40,41) IQXMSFHXWGXZKV-UHFFFAOYSA-N 531898 3-(5-(6-(4'-chloro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-carbonyl)-3,6- diazabicyclo[3.1.1]heptane-3-carbonyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05661 Protein cereblon Homo sapiens 960 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531898 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531898&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440802 463795332 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237954 CC1(C)CCC(CN2CC3CC2CN3Cc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)=C(c2ccc(F)cc2)C1 InChI=1S/C34H39FN4O3/c1-34(2)12-11-23(29(15-34)22-4-6-25(35)7-5-22)17-38-20-26-14-27(38)19-37(26)16-21-3-8-28-24(13-21)18-39(33(28)42)30-9-10-31(40)36-32(30)41/h3-8,13,26-27,30H,9-12,14-20H2,1-2H3,(H,36,40,41) LIVDFBGVKMOOPG-UHFFFAOYSA-N 531899 3-(5-((5-((4'-fluoro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-yl)methyl)- 2,5-diazabicyclo[2.2.1]heptan-2- yl)methyl)-1-oxoisoindolin-2-yl)piperidine- 2,6-dione::US20260028326, Compound GT-05401 Protein cereblon Homo sapiens 590 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531899 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531899&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440268 463795333 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237955 CC1(C)CCC(CN2CC3CC2CN3C(=O)c2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)=C(c2ccc(Cl)cc2)C1 InChI=1S/C34H37ClN4O4/c1-34(2)12-11-22(28(15-34)20-3-6-24(35)7-4-20)16-37-18-26-14-25(37)19-38(26)32(42)21-5-8-27-23(13-21)17-39(33(27)43)29-9-10-30(40)36-31(29)41/h3-8,13,25-26,29H,9-12,14-19H2,1-2H3,(H,36,40,41) XQHPSGMLRLWNTD-UHFFFAOYSA-N 531900 3-(5-(5-((4'-chloro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-yl)methyl)- 2,5-diazabicyclo[2.2.1]heptane-2- carbonyl)-1-oxoisoindolin-2-yl)piperidine- 2,6-dione::US20260028326, Compound GT-05541 Protein cereblon Homo sapiens 600 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531900 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531900&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 142754079 463795334 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237956 CC1(C)CCC(C(=O)N2CC3CCC2CN3Cc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)=C(c2ccc(Cl)cc2)C1 InChI=1S/C35H39ClN4O4/c1-35(2)14-13-28(29(16-35)22-4-6-24(36)7-5-22)34(44)39-20-25-8-9-26(39)19-38(25)17-21-3-10-27-23(15-21)18-40(33(27)43)30-11-12-31(41)37-32(30)42/h3-7,10,15,25-26,30H,8-9,11-14,16-20H2,1-2H3,(H,37,41,42) QYSGPZSMMYKFOP-UHFFFAOYSA-N 531901 3-(5-((5-(4'-chloro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-carbonyl)-2,5- diazabicyclo[2.2.2]octan-2-yl)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05662 Protein cereblon Homo sapiens 710 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531901 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531901&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440437 463795335 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237957 CC1(C)CCC(C(=O)N2CC3CCC2CN3Cc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)=C(c2ccc(F)cc2)C1 InChI=1S/C35H39FN4O4/c1-35(2)14-13-28(29(16-35)22-4-6-24(36)7-5-22)34(44)39-20-25-8-9-26(39)19-38(25)17-21-3-10-27-23(15-21)18-40(33(27)43)30-11-12-31(41)37-32(30)42/h3-7,10,15,25-26,30H,8-9,11-14,16-20H2,1-2H3,(H,37,41,42) YIBPXJJAQZZTDN-UHFFFAOYSA-N 531902 3-(5-((5-(4'-fluoro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-carbonyl)-2,5- diazabicyclo[2.2.2]octan-2-yl)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05402 Protein cereblon Homo sapiens 430 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531902 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531902&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440803 463795336 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237958 O=C1CCC(N2Cc3cc(CN4CC5CCC(C4)N5C(=O)c4ccccc4-c4ccc(Cl)cc4)ccc3C2=O)C(=O)N1 InChI=1S/C33H31ClN4O4/c34-23-8-6-21(7-9-23)26-3-1-2-4-28(26)33(42)38-24-10-11-25(38)19-36(18-24)16-20-5-12-27-22(15-20)17-37(32(27)41)29-13-14-30(39)35-31(29)40/h1-9,12,15,24-25,29H,10-11,13-14,16-19H2,(H,35,39,40) YMDIADSTGHJAAB-UHFFFAOYSA-N 531903 3-(5-((8-(4'-chloro-[1,1'-biphenyl]-2- carbonyl)-3,8-diazabicyclo[3.2.1]octan-3- yl)methyl)-1-oxoisoindolin-2-yl)piperidine- 2,6-dione::US20260028326, Compound GT-05542 Protein cereblon Homo sapiens 440 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531903 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531903&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440602 463795337 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237959 CC1(C)CCC(C(=O)N2CC3CCC2CN3C(=O)c2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)=C(c2ccc(Cl)cc2)C1 InChI=1S/C35H37ClN4O5/c1-35(2)14-13-27(28(16-35)20-3-6-23(36)7-4-20)34(45)39-19-24-8-9-25(39)18-38(24)32(43)21-5-10-26-22(15-21)17-40(33(26)44)29-11-12-30(41)37-31(29)42/h3-7,10,15,24-25,29H,8-9,11-14,16-19H2,1-2H3,(H,37,41,42) HOEJGHBAQHWXCH-UHFFFAOYSA-N 531904 3-(5-(5-(4'-chloro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-carbonyl)-2,5- diazabicyclo[2.2.2]octane-2-carbonyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05663 Protein cereblon Homo sapiens 1090 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531904 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531904&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 142322167 463795338 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237960 CC1(C)CCC(C(=O)N2CC3CC2CN3Cc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)=C(c2ccc(F)cc2)C1 InChI=1S/C34H37FN4O4/c1-34(2)12-11-27(28(15-34)21-4-6-23(35)7-5-21)33(43)38-19-24-14-25(38)18-37(24)16-20-3-8-26-22(13-20)17-39(32(26)42)29-9-10-30(40)36-31(29)41/h3-8,13,24-25,29H,9-12,14-19H2,1-2H3,(H,36,40,41) NZLOSDZLKMZGMZ-UHFFFAOYSA-N 531905 3-(5-((5-(4'-fluoro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-carbonyl)-2,5- diazabicyclo[2.2.1]heptan-2-yl)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05403 Protein cereblon Homo sapiens 550 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531905 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531905&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440771 463795339 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237961 O=C1CCC(N2Cc3cc(CN4CC5CCC4CN5C(=O)c4ccccc4-c4ccc(Cl)cc4)ccc3C2=O)C(=O)N1 InChI=1S/C33H31ClN4O4/c34-23-8-6-21(7-9-23)26-3-1-2-4-28(26)33(42)37-19-24-10-11-25(37)18-36(24)16-20-5-12-27-22(15-20)17-38(32(27)41)29-13-14-30(39)35-31(29)40/h1-9,12,15,24-25,29H,10-11,13-14,16-19H2,(H,35,39,40) HKDYHLLDVYCUKJ-UHFFFAOYSA-N 531906 3-(5-((5-(4'-chloro-[1,1'-biphenyl]-2- carbonyl)-2,5-diazabicyclo[2.2.2]octan-2- yl)methyl)-1-oxoisoindolin-2-yl)piperidine- 2,6-dione::US20260028326, Compound GT-05543 Protein cereblon Homo sapiens 450 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531906 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531906&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440607 463795340 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237962 CC1(C)CCC(C(=O)N2CC3(CN(Cc4ccc5c(c4)CN(C4CCC(=O)NC4=O)C5=O)C3)C2)=C(c2ccc(F)cc2)C1 InChI=1S/C34H37FN4O4/c1-33(2)12-11-26(27(14-33)22-4-6-24(35)7-5-22)31(42)38-19-34(20-38)17-37(18-34)15-21-3-8-25-23(13-21)16-39(32(25)43)28-9-10-29(40)36-30(28)41/h3-8,13,28H,9-12,14-20H2,1-2H3,(H,36,40,41) XJHCIAFGAFIUPK-UHFFFAOYSA-N 531907 3-(5-((6-(4'-fluoro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-carbonyl)-2,6- diazaspiro[3.3]heptan-2-yl)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05664 Protein cereblon Homo sapiens 560 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531907 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531907&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440488 463795341 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237963 CC1(C)CCC(C(=O)N2CCC3(CC2)CN(Cc2ccc4c(c2)CN(C2CCC(=O)NC2=O)C4=O)C3)=C(c2ccc(F)cc2)C1 InChI=1S/C36H41FN4O4/c1-35(2)12-11-28(29(18-35)24-4-6-26(37)7-5-24)33(44)40-15-13-36(14-16-40)21-39(22-36)19-23-3-8-27-25(17-23)20-41(34(27)45)30-9-10-31(42)38-32(30)43/h3-8,17,30H,9-16,18-22H2,1-2H3,(H,38,42,43) QGEDWOGNAFZLBT-UHFFFAOYSA-N 531908 3-(5-((7-(4'-fluoro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-carbonyl)-2,7- diazaspiro[3.5]nonan-2-yl)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05404 Protein cereblon Homo sapiens 490 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531908 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531908&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440908 463795342 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237964 O=C1CCC(N2Cc3cc(CN4CCN(Cc5cccc(-c6ccc(Cl)cn6)c5)CC4)ccc3C2=O)C(=O)N1 InChI=1S/C30H30ClN5O3/c31-24-5-7-26(32-16-24)22-3-1-2-20(14-22)17-34-10-12-35(13-11-34)18-21-4-6-25-23(15-21)19-36(30(25)39)27-8-9-28(37)33-29(27)38/h1-7,14-16,27H,8-13,17-19H2,(H,33,37,38) HREGGDAYCRLBPH-UHFFFAOYSA-N 531909 3-(5-((4-(3-(5-chloropyridin-2- yl)benzyl)piperazin-1-yl)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05596 Protein cereblon Homo sapiens 1340 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531909 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531909&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440913 463795343 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237965 O=C1CCC(N2Cc3cc(CN4C5CC4CN(C(=O)c4ccccc4-c4ccc(Cl)cc4)C5)ccc3C2=O)C(=O)N1 InChI=1S/C32H29ClN4O4/c33-22-8-6-20(7-9-22)25-3-1-2-4-27(25)31(40)35-17-23-14-24(18-35)36(23)15-19-5-10-26-21(13-19)16-37(32(26)41)28-11-12-29(38)34-30(28)39/h1-10,13,23-24,28H,11-12,14-18H2,(H,34,38,39) DFXHHGKKTRDBEV-UHFFFAOYSA-N 531910 3-(5-((3-(4'-chloro-[1,1'-biphenyl]-2- carbonyl)-3,6-diazabicyclo[3.1.1]heptan-6- yl)methyl)-1-oxoisoindolin-2-yl)piperidine- 2,6-dione::US20260028326, Compound GT-05665 Protein cereblon Homo sapiens 600 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531910 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531910&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 142322163 463795344 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237966 CC1(C)CCC(C(=O)N2CC3CN(Cc4ccc5c(c4)CN(C4CCC(=O)NC4=O)C5=O)CC3C2)=C(c2ccc(F)cc2)C1 InChI=1S/C35H39FN4O4/c1-35(2)12-11-28(29(14-35)22-4-6-26(36)7-5-22)33(43)39-18-24-16-38(17-25(24)19-39)15-21-3-8-27-23(13-21)20-40(34(27)44)30-9-10-31(41)37-32(30)42/h3-8,13,24-25,30H,9-12,14-20H2,1-2H3,(H,37,41,42) BRYIOQAWPZPVCH-UHFFFAOYSA-N 531911 3-(5-((5-(4'-fluoro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2- carbonyl)hexahydropyrrolo[3,4-c]pyrrol- 2(1H)-yl)methyl)-1-oxoisoindolin-2- yl)piperidine-2,6-dione::US20260028326, Compound GT-05405 Protein cereblon Homo sapiens 500 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531911 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531911&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440425 463795345 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237967 O=C1CCC(N2Cc3cc(CN4CCN(Cc5cnc(-c6ccccc6)cn5)CC4)ccc3C2=O)C(=O)N1 InChI=1S/C29H30N6O3/c36-27-9-8-26(28(37)32-27)35-18-22-14-20(6-7-24(22)29(35)38)17-33-10-12-34(13-11-33)19-23-15-31-25(16-30-23)21-4-2-1-3-5-21/h1-7,14-16,26H,8-13,17-19H2,(H,32,36,37) SQHWQDDSMXXXMJ-UHFFFAOYSA-N 531912 3-(1-oxo-5-((4-((5-phenylpyrazin-2- yl)methyl)piperazin-1- yl)methyl)isoindolin-2-yl)piperidine-2,6- dione::US20260028326, Compound GT-05544 Protein cereblon Homo sapiens 840 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531912 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531912&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440298 463795346 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237968 O=C1CCC(N2Cc3c(ccc(CN4C5CC4CN(C(=O)c4ccccc4-c4ccc(Cl)cc4)C5)c3F)C2=O)C(=O)N1 InChI=1S/C32H28ClFN4O4/c33-20-8-5-18(6-9-20)23-3-1-2-4-24(23)31(41)36-15-21-13-22(16-36)37(21)14-19-7-10-25-26(29(19)34)17-38(32(25)42)27-11-12-28(39)35-30(27)40/h1-10,21-22,27H,11-17H2,(H,35,39,40) ILYAIOSWCXFPMP-UHFFFAOYSA-N 531913 3-(5-((3-(4'-chloro-[1,1'-biphenyl]-2- carbonyl)-3,6-diazabicyclo[3.1.1]heptan-6- yl)methyl)-4-fluoro-1-oxoisoindolin-2- yl)piperidine-2,6-dione::US20260028326, Compound GT-05666 Protein cereblon Homo sapiens 690 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531913 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531913&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440605 463795347 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237969 CC1(C)CCC(C(=O)N2CCN(Nc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)CC2)=C(c2ccc(Cl)cc2)C1 InChI=1S/C32H36ClN5O4/c1-32(2)12-11-25(26(18-32)20-3-5-22(33)6-4-20)30(41)36-13-15-37(16-14-36)35-23-7-8-24-21(17-23)19-38(31(24)42)27-9-10-28(39)34-29(27)40/h3-8,17,27,35H,9-16,18-19H2,1-2H3,(H,34,39,40) RHGSYASONZWGDL-UHFFFAOYSA-N 531914 3-(5-((4-(4'-chloro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2- carbonyl)piperazin-1-yl)amino)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05417 Protein cereblon Homo sapiens 1480 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531914 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531914&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440311 463795348 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237970 O=C1CCC(N2Cc3cc(CN4CCN(Cc5cccc(-c6cccs6)c5)CC4)ccc3C2=O)C(=O)N1 InChI=1S/C29H30N4O3S/c34-27-9-8-25(28(35)30-27)33-19-23-16-21(6-7-24(23)29(33)36)18-32-12-10-31(11-13-32)17-20-3-1-4-22(15-20)26-5-2-14-37-26/h1-7,14-16,25H,8-13,17-19H2,(H,30,34,35) BPQWZOHAMXIMNO-UHFFFAOYSA-N 531915 3-(1-oxo-5-((4-(3-(thiophen-2- yl)benzyl)piperazin-1-yl)methyl)isoindolin- 2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05597 Protein cereblon Homo sapiens 1400 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531915 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531915&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440894 463795349 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237971 O=C1CCC(N2Cc3cc(CN4C5CC4CN(C(=O)c4ccccc4-c4ccc(Cl)cc4)C5)c(F)cc3C2=O)C(=O)N1 InChI=1S/C32H28ClFN4O4/c33-21-7-5-18(6-8-21)24-3-1-2-4-25(24)31(41)36-16-22-12-23(17-36)37(22)15-20-11-19-14-38(32(42)26(19)13-27(20)34)28-9-10-29(39)35-30(28)40/h1-8,11,13,22-23,28H,9-10,12,14-17H2,(H,35,39,40) AAPQAMSAPDCXFE-UHFFFAOYSA-N 531916 3-(5-((3-(4'-chloro-[1,1'-biphenyl]-2- carbonyl)-3,6-diazabicyclo[3.1.1]heptan-6- yl)methyl)-6-fluoro-1-oxoisoindolin-2- yl)piperidine-2,6-dione::US20260028326, Compound GT-05667 Protein cereblon Homo sapiens 750 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531916 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531916&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 142754119 463795350 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237972 CC1(C)CCC(C(=O)N2CCC(Cc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)CC2)=C(c2ccc(Cl)cc2)C1 InChI=1S/C34H38ClN3O4/c1-34(2)14-11-27(28(19-34)23-4-6-25(35)7-5-23)32(41)37-15-12-21(13-16-37)17-22-3-8-26-24(18-22)20-38(33(26)42)29-9-10-30(39)36-31(29)40/h3-8,18,21,29H,9-17,19-20H2,1-2H3,(H,36,39,40) RGFUTXVMMFYVOU-UHFFFAOYSA-N 531917 3-(5-((1-(4'-chloro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2- carbonyl)piperidin-4-yl)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05418 Protein cereblon Homo sapiens 540 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531917 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531917&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440918 463795351 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237973 O=C1CCC(N2Cc3cc(CN4CCN(Cc5ccc(-c6ccc(Cl)cc6)cc5)CC4)ccc3C2=O)C(=O)N1 InChI=1S/C31H31ClN4O3/c32-26-8-6-24(7-9-26)23-4-1-21(2-5-23)18-34-13-15-35(16-14-34)19-22-3-10-27-25(17-22)20-36(31(27)39)28-11-12-29(37)33-30(28)38/h1-10,17,28H,11-16,18-20H2,(H,33,37,38) DWYSWHUSCLUAFP-UHFFFAOYSA-N 531918 3-(5-((4-((4'-chloro-[1,1'-biphenyl]-4- yl)methyl)piperazin-1-yl)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05598 Protein cereblon Homo sapiens 680 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531918 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531918&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440915 463795352 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237974 O=C1CCC(N2Cc3cc(CN4C5CC4CN(C(=O)c4ccccc4-c4ccc(Cl)cc4)C5)cc(F)c3C2=O)C(=O)N1 InChI=1S/C32H28ClFN4O4/c33-21-7-5-19(6-8-21)24-3-1-2-4-25(24)31(41)36-16-22-13-23(17-36)37(22)14-18-11-20-15-38(32(42)29(20)26(34)12-18)27-9-10-28(39)35-30(27)40/h1-8,11-12,22-23,27H,9-10,13-17H2,(H,35,39,40) MZKIARSZHAMSIF-UHFFFAOYSA-N 531919 3-(5-((3-(4'-chloro-[1,1'-biphenyl]-2- carbonyl)-3,6-diazabicyclo[3.1.1]heptan-6- yl)methyl)-7-fluoro-1-oxoisoindolin-2- yl)piperidine-2,6-dione::US20260028326, Compound GT-05668 Protein cereblon Homo sapiens 650 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531919 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531919&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440230 463795353 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237975 CC1(C)CCC(C(=O)N2CC(Cc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)C2)=C(c2ccc(Cl)cc2)C1 InChI=1S/C32H34ClN3O4/c1-32(2)12-11-25(26(15-32)21-4-6-23(33)7-5-21)30(39)35-16-20(17-35)13-19-3-8-24-22(14-19)18-36(31(24)40)27-9-10-28(37)34-29(27)38/h3-8,14,20,27H,9-13,15-18H2,1-2H3,(H,34,37,38) AEJBDUWHFDAWKM-UHFFFAOYSA-N 531920 3-(5-((1-(4'-chloro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2- carbonyl)azetidin-3-yl)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05419 Protein cereblon Homo sapiens 720 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531920 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531920&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 142754113 463795354 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237976 O=C1CCC(N2C(=O)c3ccc(CN4CCN(Cc5ccc(-c6ccc(Cl)cc6)cc5)CC4)cc3C2=O)C(=O)N1 InChI=1S/C31H29ClN4O4/c32-24-8-6-23(7-9-24)22-4-1-20(2-5-22)18-34-13-15-35(16-14-34)19-21-3-10-25-26(17-21)31(40)36(30(25)39)27-11-12-28(37)33-29(27)38/h1-10,17,27H,11-16,18-19H2,(H,33,37,38) IPVQZZUILGWWMP-UHFFFAOYSA-N 531921 5-((4-((4'-chloro-[1,1'-biphenyl]-4- yl)methyl)piperazin-1-yl)methyl)-2-(2,6- dioxopiperidin-3-yl)isoindoline-1,3-dione::US20260028326, Compound GT-05599 Protein cereblon Homo sapiens 1670 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531921 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531921&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 142754157 463795355 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237977 O=C1CCC(N2Cc3cc(CN4CC5CC(C4)N5C(=O)c4ccccc4-c4ccc(Cl)cc4)ccc3C2=O)C(=O)N1 InChI=1S/C32H29ClN4O4/c33-22-8-6-20(7-9-22)25-3-1-2-4-27(25)32(41)37-23-14-24(37)18-35(17-23)15-19-5-10-26-21(13-19)16-36(31(26)40)28-11-12-29(38)34-30(28)39/h1-10,13,23-24,28H,11-12,14-18H2,(H,34,38,39) WEJLGFQTYPLYCA-UHFFFAOYSA-N 531922 3-(5-((6-(4'-chloro-[1,1'-biphenyl]-2- carbonyl)-3,6-diazabicyclo[3.1.1]heptan-3- yl)methyl)-1-oxoisoindolin-2-yl)piperidine- 2,6-dione::US20260028326, Compound GT-05669 Protein cereblon Homo sapiens 630 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531922 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531922&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 142754092 463795356 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237978 CC1(C)CCC(C(=O)N2CC(=Cc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)C2)=C(c2ccc(Cl)cc2)C1 InChI=1S/C32H32ClN3O4/c1-32(2)12-11-25(26(15-32)21-4-6-23(33)7-5-21)30(39)35-16-20(17-35)13-19-3-8-24-22(14-19)18-36(31(24)40)27-9-10-28(37)34-29(27)38/h3-8,13-14,27H,9-12,15-18H2,1-2H3,(H,34,37,38) UFCUCROFBZHCIN-UHFFFAOYSA-N 531923 3-(5-((1-(4'-chloro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2- carbonyl)azetidin-3-ylidene)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05420 Protein cereblon Homo sapiens 730 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531923 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531923&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440541 463795357 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237979 O=C1CCC(N2Cc3cc(CN4CC5CCC(C4)N5Cc4ccccc4-c4ccc(Cl)cc4)ccc3C2=O)C(=O)N1 InChI=1S/C33H33ClN4O3/c34-25-8-6-22(7-9-25)28-4-2-1-3-23(28)17-37-26-10-11-27(37)20-36(19-26)16-21-5-12-29-24(15-21)18-38(33(29)41)30-13-14-31(39)35-32(30)40/h1-9,12,15,26-27,30H,10-11,13-14,16-20H2,(H,35,39,40) ABEUVFHBKNIWCI-UHFFFAOYSA-N 531924 3-(5-((8-((4'-chloro-[1,1'-biphenyl]-2- yl)methyl)-3,8-diazabicyclo[3.2.1]octan-3- yl)methyl)-1-oxoisoindolin-2-yl)piperidine- 2,6-dione::US20260028326, Compound GT-05618 Protein cereblon Homo sapiens 580 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=531924 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=531924&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 134440527 463795358 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237980 CC1(C)CC(c2ccc(Cl)cc2)=C(CN2CCN(Cc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)CC2)CO1 InChI=1S/C32H37ClN4O4/c1-32(2)16-27(22-4-6-25(33)7-5-22)24(20-41-32)18-36-13-11-35(12-14-36)17-21-3-8-26-23(15-21)19-37(31(26)40)28-9-10-29(38)34-30(28)39/h3-8,15,28H,9-14,16-20H2,1-2H3,(H,34,38,39) BCSHJLMBCIOCLJ-UHFFFAOYSA-N 535886 3-(5-((4-((4-(4-chlorophenyl)-6,6- dimethyl-5,6-dihydro-2H-pyran-3- yl)methyl)piperazin-1-yl)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05672 Protein cereblon Homo sapiens 580 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=535886 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=535886&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 156403312 464921068 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237981 CC1(C)CCC(C(=O)N2CC(O)(C(O)c3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)C2)=C(c2ccc(Cl)cc2)C1 InChI=1S/C32H34ClN3O6/c1-31(2)12-11-23(24(14-31)18-3-6-21(33)7-4-18)29(40)35-16-32(42,17-35)27(38)19-5-8-22-20(13-19)15-36(30(22)41)25-9-10-26(37)34-28(25)39/h3-8,13,25,27,38,42H,9-12,14-17H2,1-2H3,(H,34,37,39) MKUAPXJPWZZTRX-UHFFFAOYSA-N 535887 3-(5-((1-(4'-chloro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-carbonyl)-3- hydroxyazetidin-3-yl)(hydroxy)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05426 Protein cereblon Homo sapiens 620 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=535887 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=535887&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 156403320 464921069 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237982 O=C1CCC(N2Cc3cc(CN4CC5CCC4CN5Cc4ccccc4-c4ccc(Cl)cc4)ccc3C2=O)C(=O)N1 InChI=1S/C33H33ClN4O3/c34-25-8-6-22(7-9-25)28-4-2-1-3-23(28)17-37-20-26-10-11-27(37)19-36(26)16-21-5-12-29-24(15-21)18-38(33(29)41)30-13-14-31(39)35-32(30)40/h1-9,12,15,26-27,30H,10-11,13-14,16-20H2,(H,35,39,40) LRDCPQWCBHSTPL-UHFFFAOYSA-N 535888 3-(5-((5-((4'-chloro-[1,1'-biphenyl]-2- yl)methyl)-2,5-diazabicyclo[2.2.2]octan-2- yl)methyl)-1-oxoisoindolin-2-yl)piperidine- 2,6-dione::US20260028326, Compound GT-05619 Protein cereblon Homo sapiens 590 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=535888 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=535888&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 138491363 464921070 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237983 CC1(C)CC(c2ccc(Cl)cc2)=C(CN2CCN(C(=O)c3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)CC2)CO1 InChI=1S/C32H35ClN4O5/c1-32(2)16-26(20-3-6-24(33)7-4-20)23(19-42-32)17-35-11-13-36(14-12-35)30(40)21-5-8-25-22(15-21)18-37(31(25)41)27-9-10-28(38)34-29(27)39/h3-8,15,27H,9-14,16-19H2,1-2H3,(H,34,38,39) VDXQWRZQFOENJW-UHFFFAOYSA-N 535889 3-(5-(4-((4-(4-chlorophenyl)-6,6-dimethyl- 5,6-dihydro-2H-pyran-3- yl)methyl)piperazine-1-carbonyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05673 Protein cereblon Homo sapiens 1140 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=535889 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=535889&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 156403317 464921071 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237984 CC1(C)CCC(CN2CC(O)(C(O)c3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)C2)=C(c2ccc(Cl)cc2)C1 InChI=1S/C32H36ClN3O5/c1-31(2)12-11-21(25(14-31)19-3-6-23(33)7-4-19)15-35-17-32(41,18-35)28(38)20-5-8-24-22(13-20)16-36(30(24)40)26-9-10-27(37)34-29(26)39/h3-8,13,26,28,38,41H,9-12,14-18H2,1-2H3,(H,34,37,39) YPEMMVFPFNFJGJ-UHFFFAOYSA-N 535890 3-(5-((1-((4'-chloro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-yl)methyl)-3- hydroxyazetidin-3-yl)(hydroxy)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05427 Protein cereblon Homo sapiens 950 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=535890 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=535890&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 156403357 464921072 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237985 O=C1CCC(N2Cc3cc(CN4CC5(CCN(C(=O)c6ccccc6-c6ccc(Cl)cc6)CC5)C4)ccc3C2=O)C(=O)N1 InChI=1S/C34H33ClN4O4/c35-25-8-6-23(7-9-25)26-3-1-2-4-28(26)32(42)38-15-13-34(14-16-38)20-37(21-34)18-22-5-10-27-24(17-22)19-39(33(27)43)29-11-12-30(40)36-31(29)41/h1-10,17,29H,11-16,18-21H2,(H,36,40,41) XLGUGTLFQDRUHD-UHFFFAOYSA-N 535891 3-(5-((7-(4'-chloro-[1,1'-biphenyl]-2- carbonyl)-2,7-diazaspiro[3.5]nonan-2- yl)methyl)-1-oxoisoindolin-2-yl)piperidine- 2,6-dione::US20260028326, Compound GT-05620 Protein cereblon Homo sapiens 590 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=535891 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=535891&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 156403322 464921073 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237986 CC1(C)CCC(CN2CCC3(CC2)CN(Cc2ccc4c(c2)CN(C2CCC(=O)NC2=O)C4=O)C3)=C(c2ccc(Cl)cc2)C1 InChI=1S/C36H43ClN4O3/c1-35(2)12-11-26(30(18-35)25-4-6-28(37)7-5-25)20-39-15-13-36(14-16-39)22-40(23-36)19-24-3-8-29-27(17-24)21-41(34(29)44)31-9-10-32(42)38-33(31)43/h3-8,17,31H,9-16,18-23H2,1-2H3,(H,38,42,43) QNKLWGUNXZOVQA-UHFFFAOYSA-N 535892 3-(5-((7-((4'-chloro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-yl)methyl)- 2,7-diazaspiro[3.5]nonan-2-yl)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05677 Protein cereblon Homo sapiens 1230 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=535892 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=535892&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 156403361 464921074 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237987 CC1(C)CCC(CN2CC(Cc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)C2)=C(c2ccc(Cl)cc2)C1 InChI=1S/C32H36ClN3O3/c1-32(2)12-11-23(27(15-32)22-4-6-25(33)7-5-22)18-35-16-21(17-35)13-20-3-8-26-24(14-20)19-36(31(26)39)28-9-10-29(37)34-30(28)38/h3-8,14,21,28H,9-13,15-19H2,1-2H3,(H,34,37,38) NQQDKIMIHNFZSW-UHFFFAOYSA-N 535893 3-(5-((1-((4'-chloro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2- yl)methyl)azetidin-3-yl)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05428 Protein cereblon Homo sapiens 1080 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=535893 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=535893&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 156403287 464921075 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237988 O=C1CCC(N2Cc3cc(C(=O)N4CC5CCC(C4)N5Cc4ccccc4-c4ccc(Cl)cc4)ccc3C2=O)C(=O)N1 InChI=1S/C33H31ClN4O4/c34-24-8-5-20(6-9-24)27-4-2-1-3-22(27)16-37-25-10-11-26(37)19-36(18-25)32(41)21-7-12-28-23(15-21)17-38(33(28)42)29-13-14-30(39)35-31(29)40/h1-9,12,15,25-26,29H,10-11,13-14,16-19H2,(H,35,39,40) RBTSQDZWVYRRCU-UHFFFAOYSA-N 535894 3-(5-(8-((4'-chloro-[1,1'-biphenyl]-2- yl)methyl)-3,8-diazabicyclo[3.2.1]octane- 3-carbonyl)-1-oxoisoindolin-2- yl)piperidine-2,6-dione::US20260028326, Compound GT-05621 Protein cereblon Homo sapiens 1100 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=535894 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=535894&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 156403352 464921076 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237989 CC1(C)CCC(C(=O)N2CCCN(Cc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)CC2)=C(c2ccc(Cl)cc2)C1 InChI=1S/C34H39ClN4O4/c1-34(2)13-12-27(28(19-34)23-5-7-25(35)8-6-23)32(42)38-15-3-14-37(16-17-38)20-22-4-9-26-24(18-22)21-39(33(26)43)29-10-11-30(40)36-31(29)41/h4-9,18,29H,3,10-17,19-21H2,1-2H3,(H,36,40,41) JUUITCONARELEM-UHFFFAOYSA-N 535895 3-(5-((4-(4'-chloro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-carbonyl)-1,4- diazepan-1-yl)methyl)-1-oxoisoindolin-2- yl)piperidine-2,6-dione::US20260028326, Compound GT-05680 Protein cereblon Homo sapiens 980 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=535895 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=535895&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 156403342 464921077 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237990 CC1(C)CCC(CN2C3CCC2CN(c2ccc4c(c2)CN(C2CCC(=O)NC2=O)C4=O)C3)=C(c2ccc(Cl)cc2)C1 InChI=1S/C34H39ClN4O3/c1-34(2)14-13-22(29(16-34)21-3-5-24(35)6-4-21)17-38-26-7-8-27(38)20-37(19-26)25-9-10-28-23(15-25)18-39(33(28)42)30-11-12-31(40)36-32(30)41/h3-6,9-10,15,26-27,30H,7-8,11-14,16-20H2,1-2H3,(H,36,40,41) HGBTZONMZQMOFI-UHFFFAOYSA-N 535896 3-(5-(8-((4'-chloro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-yl)methyl)- 3,8-diazabicyclo[3.2.1]octan-3-yl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05429 Protein cereblon Homo sapiens 1490 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=535896 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=535896&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 138491394 464921078 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237991 O=C1CCC(N2Cc3cc(C(=O)N4CC5CCC4CN5Cc4ccccc4-c4ccc(Cl)cc4)ccc3C2=O)C(=O)N1 InChI=1S/C33H31ClN4O4/c34-24-8-5-20(6-9-24)27-4-2-1-3-22(27)16-36-18-26-11-10-25(36)19-37(26)32(41)21-7-12-28-23(15-21)17-38(33(28)42)29-13-14-30(39)35-31(29)40/h1-9,12,15,25-26,29H,10-11,13-14,16-19H2,(H,35,39,40) WEPQMJDEZKCCIE-UHFFFAOYSA-N 535899 3-(5-(5-((4'-chloro-[1,1'-biphenyl]-2- yl)methyl)-2,5-diazabicyclo[2.2.2]octane- 2-carbonyl)-1-oxoisoindolin-2- yl)piperidine-2,6-dione::US20260028326, Compound GT-05622 Protein cereblon Homo sapiens 910 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=535899 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=535899&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 152785364 464921081 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237992 CC1(C)CCC(C(=O)N2CC3(CN(Cc4ccc5c(c4)CN(C4CCC(=O)NC4=O)C5=O)C3)C2)=C(c2ccc(Cl)cc2)C1 InChI=1S/C34H37ClN4O4/c1-33(2)12-11-26(27(14-33)22-4-6-24(35)7-5-22)31(42)38-19-34(20-38)17-37(18-34)15-21-3-8-25-23(13-21)16-39(32(25)43)28-9-10-29(40)36-30(28)41/h3-8,13,28H,9-12,14-20H2,1-2H3,(H,36,40,41) BQFHUFOCRICLHO-UHFFFAOYSA-N 535900 3-(5-((6-(4'-chloro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-carbonyl)-2,6- diazaspiro[3.3]heptan-2-yl)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05681 Protein cereblon Homo sapiens 460 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=535900 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=535900&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 156403356 464921082 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237993 CC1(C)CCC(CN2CC3CC(C2)N3C(=O)c2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)=C(c2ccc(Cl)cc2)C1 InChI=1S/C34H37ClN4O4/c1-34(2)12-11-22(28(15-34)20-3-6-24(35)7-4-20)16-37-18-25-14-26(19-37)39(25)32(42)21-5-8-27-23(13-21)17-38(33(27)43)29-9-10-30(40)36-31(29)41/h3-8,13,25-26,29H,9-12,14-19H2,1-2H3,(H,36,40,41) OUJBKVATNDURJL-UHFFFAOYSA-N 535901 3-(5-(3-((4'-chloro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-yl)methyl)- 3,6-diazaspiro[3.1.1]heptane-6- carbonyl)-1-oxoisoindolin-2-yl)piperidine- 2,6-dione::US20260028326, Compound GT-05440 Protein cereblon Homo sapiens 940 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=535901 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=535901&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 138491364 464921083 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237994 O=C1CCC(N2Cc3cc(CN4CCN(Cc5cccc(-c6ccc[nH]6)c5)CC4)ccc3C2=O)C(=O)N1 InChI=1S/C29H31N5O3/c35-27-9-8-26(28(36)31-27)34-19-23-16-21(6-7-24(23)29(34)37)18-33-13-11-32(12-14-33)17-20-3-1-4-22(15-20)25-5-2-10-30-25/h1-7,10,15-16,26,30H,8-9,11-14,17-19H2,(H,31,35,36) JSPNYOGUNYPUNZ-UHFFFAOYSA-N 535902 3-(5-((4-(3-(1H-pyrrol-2- yl)benzyl)piperazin-1-yl)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05733 Protein cereblon Homo sapiens 210 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=535902 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=535902&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 156403327 464921084 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237995 CC1(C)CCC(C(=O)N2CC3(C2)CN(C(=O)c2ccc4c(c2)CN(C2CCC(=O)NC2=O)C4=O)C3)=C(c2ccc(Cl)cc2)C1 InChI=1S/C34H35ClN4O5/c1-33(2)12-11-25(26(14-33)20-3-6-23(35)7-4-20)31(43)38-18-34(19-38)16-37(17-34)30(42)21-5-8-24-22(13-21)15-39(32(24)44)27-9-10-28(40)36-29(27)41/h3-8,13,27H,9-12,14-19H2,1-2H3,(H,36,40,41) WVLAFLMGHQVAFL-UHFFFAOYSA-N 535903 3-(5-(6-(4'-chloro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-carbonyl)-2,6- diazaspiro[3.3]heptane-2-carbonyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05682 Protein cereblon Homo sapiens 570 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=535903 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=535903&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 152861764 464921085 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237996 CC1(C)CCC(CN2C[C@H]3C[C@@H]2CN3C(=O)c2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)=C(c2ccc(Cl)cc2)C1 InChI=1S/C34H37ClN4O4/c1-34(2)12-11-22(28(15-34)20-3-6-24(35)7-4-20)16-37-18-26-14-25(37)19-38(26)32(42)21-5-8-27-23(13-21)17-39(33(27)43)29-9-10-30(40)36-31(29)41/h3-8,13,25-26,29H,9-12,14-19H2,1-2H3,(H,36,40,41) XQHPSGMLRLWNTD-UHFFFAOYSA-N 535904 3-(5-((1R,4R)-5-((4'-chloro-5,5-dimethyl- 3,4,5,6-tetrahydro-[1,1'-biphenyl]-2- yl)methyl)-2,5-diazabicyclo[2.2.1]heptane- 2-carbonyl)-1-oxoisoindolin-2- yl)piperidine-2,6-dione::US20260028326, Compound GT-05441 Protein cereblon Homo sapiens 1570 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=535904 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=535904&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 149068989 464921086 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237997 O=C1CCC(N2Cc3cc(CN4CCN(Cc5ccc(-c6cccs6)s5)CC4)ccc3C2=O)C(=O)N1 InChI=1S/C27H28N4O3S2/c32-25-8-6-22(26(33)28-25)31-16-19-14-18(3-5-21(19)27(31)34)15-29-9-11-30(12-10-29)17-20-4-7-24(36-20)23-2-1-13-35-23/h1-5,7,13-14,22H,6,8-12,15-17H2,(H,28,32,33) RHMXUDVZPAPABP-UHFFFAOYSA-N 535908 3-(5-((4-([2,2'-bithiophen]-5- ylmethyl)piperazin-1-yl)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05624 Protein cereblon Homo sapiens 470 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=535908 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=535908&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 156403347 464921090 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237998 Cn1cccc1-c1ccccc1CN1CCN(Cc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)CC1 InChI=1S/C30H33N5O3/c1-32-12-4-7-26(32)24-6-3-2-5-22(24)19-34-15-13-33(14-16-34)18-21-8-9-25-23(17-21)20-35(30(25)38)27-10-11-28(36)31-29(27)37/h2-9,12,17,27H,10-11,13-16,18-20H2,1H3,(H,31,36,37) JHWWCEAZUIBANQ-UHFFFAOYSA-N 535910 3-(5-((4-(2-(1-methyl-1H-pyrrol-2- yl)benzyl)piperazin-1-yl)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05683 Protein cereblon Homo sapiens 750 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=535910 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=535910&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 156403299 464921092 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 237999 CC1(C)CCC(CN2C[C@@H]3C[C@H]2CN3C(=O)c2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)=C(c2ccc(Cl)cc2)C1 InChI=1S/C34H37ClN4O4/c1-34(2)12-11-22(28(15-34)20-3-6-24(35)7-4-20)16-37-18-26-14-25(37)19-38(26)32(42)21-5-8-27-23(13-21)17-39(33(27)43)29-9-10-30(40)36-31(29)41/h3-8,13,25-26,29H,9-12,14-19H2,1-2H3,(H,36,40,41) XQHPSGMLRLWNTD-UHFFFAOYSA-N 535911 3-(5-((1S,4S)-5-((4'-chloro-5,5-dimethyl- 3,4,5,6-tetrahydro-[1,1'-biphenyl]-2- yl)methyl)-2,5-diazabicyclo[2.2.1]heptane- 2-carbonyl)-1-oxoisoindolin-2- yl)piperidine-2,6-dione::US20260028326, Compound GT-05442 Protein cereblon Homo sapiens 670 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=535911 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=535911&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 156403346 464921093 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 238000 O=C1CCC(N2C(=O)c3ccc(CN4CCN(Cc5ccc(-c6ccc(Cl)cc6)s5)CC4)cc3C2=O)C(=O)N1 InChI=1S/C29H27ClN4O4S/c30-20-4-2-19(3-5-20)25-9-6-21(39-25)17-33-13-11-32(12-14-33)16-18-1-7-22-23(15-18)29(38)34(28(22)37)24-8-10-26(35)31-27(24)36/h1-7,9,15,24H,8,10-14,16-17H2,(H,31,35,36) XZYKCUOOVKZAIP-UHFFFAOYSA-N 535912 3-(5-((4-((5-(4-chlorophenyl)thiophen-2- yl)methyl)piperazin-1-yl)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05625 Protein cereblon Homo sapiens 1670 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=535912 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=535912&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 156403298 464921094 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 238001 O=C1CCC(N2Cc3cc(CN4CCN(Cc5ccccc5-c5cncs5)CC4)ccc3C2=O)C(=O)N1 InChI=1S/C28H29N5O3S/c34-26-8-7-24(27(35)30-26)33-17-21-13-19(5-6-23(21)28(33)36)15-31-9-11-32(12-10-31)16-20-3-1-2-4-22(20)25-14-29-18-37-25/h1-6,13-14,18,24H,7-12,15-17H2,(H,30,34,35) PBKJQJRJWMTYNF-UHFFFAOYSA-N 535913 3-(1-oxo-5-((4-(2-(thiazol-5- yl)benzyl)piperazin-1-yl)methyl)isoindolin- 2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05684 Protein cereblon Homo sapiens 540 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=535913 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=535913&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 156403319 464921095 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 238002 CC1(C)CCC(CN2CCN(C(=O)c3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)CC2)=C(c2ccc(Cl)cc2)C1 InChI=1S/C33H37ClN4O4/c1-33(2)12-11-23(27(18-33)21-3-6-25(34)7-4-21)19-36-13-15-37(16-14-36)31(41)22-5-8-26-24(17-22)20-38(32(26)42)28-9-10-29(39)35-30(28)40/h3-8,17,28H,9-16,18-20H2,1-2H3,(H,35,39,40) MOWFLQNDUAIXLE-UHFFFAOYSA-N 535914 3-(5-(4-((4'-chloro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2- yl)methyl)piperazine-1-carbonyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05445 Protein cereblon Homo sapiens 1910 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=535914 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=535914&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 156403310 464921096 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 238003 O=C1CCC(N2Cc3cc(CN4CCN(Cc5ccc(-c6cccs6)o5)CC4)ccc3C2=O)C(=O)N1 InChI=1S/C27H28N4O4S/c32-25-8-6-22(26(33)28-25)31-16-19-14-18(3-5-21(19)27(31)34)15-29-9-11-30(12-10-29)17-20-4-7-23(35-20)24-2-1-13-36-24/h1-5,7,13-14,22H,6,8-12,15-17H2,(H,28,32,33) BIMOTWRTATZQBR-UHFFFAOYSA-N 535915 3-(1-oxo-5-((4-((5-(thiophen-2-yl)furan-2- yl)methyl)piperazin-1- yl)methyl)isoindolin-2-yl)piperidine-2,6- dione::US20260028326, Compound GT-05627 Protein cereblon Homo sapiens 260 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=535915 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=535915&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 156403365 464921097 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 238004 CC1(C)CCC(CN2CC3(C2)CN(Cc2ccc4c(c2)CN(C2CCC(=O)NC2=O)C4=O)C3)=C(c2ccc(Cl)cc2)C1 InChI=1S/C34H39ClN4O3/c1-33(2)12-11-24(28(14-33)23-4-6-26(35)7-5-23)16-38-20-34(21-38)18-37(19-34)15-22-3-8-27-25(13-22)17-39(32(27)42)29-9-10-30(40)36-31(29)41/h3-8,13,29H,9-12,14-21H2,1-2H3,(H,36,40,41) VTDGAVARBQJDDB-UHFFFAOYSA-N 535916 3-(5-((6-((4'-chloro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-yl)methyl)- 2,6-diazaspiro[3.3]heptan-2-yl)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05685 Protein cereblon Homo sapiens 1160 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=535916 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=535916&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 153283834 464921098 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 238005 CC1(C)CCC(CN2C3CCC2CN(C(=O)c2ccc4c(c2)CN(C2CCC(=O)NC2=O)C4=O)C3)=C(c2ccc(Cl)cc2)C1 InChI=1S/C35H39ClN4O4/c1-35(2)14-13-23(29(16-35)21-3-6-25(36)7-4-21)17-39-26-8-9-27(39)20-38(19-26)33(43)22-5-10-28-24(15-22)18-40(34(28)44)30-11-12-31(41)37-32(30)42/h3-7,10,15,26-27,30H,8-9,11-14,16-20H2,1-2H3,(H,37,41,42) NLVZZJCSSVWSNU-UHFFFAOYSA-N 535917 3-(5-(8-((4'-chloro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-yl)methyl)- 3,8-diazabicyclo[3.2.1]octane-3-carbonyl)- 1-oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05446 Protein cereblon Homo sapiens 1870 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=535917 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=535917&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 156403321 464921099 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 238006 O=C1CCC(N2Cc3cc(CN4CCN(Cc5cccc(-c6ccc(Cl)cc6)c5)CC4)ccc3C2=O)C(=O)N1 InChI=1S/C31H31ClN4O3/c32-26-7-5-23(6-8-26)24-3-1-2-21(16-24)18-34-12-14-35(15-13-34)19-22-4-9-27-25(17-22)20-36(31(27)39)28-10-11-29(37)33-30(28)38/h1-9,16-17,28H,10-15,18-20H2,(H,33,37,38) NUHWHRZAUVKUPG-UHFFFAOYSA-N 535918 3-(5-((4-((4'-chloro-[1,1'-biphenyl]-3- yl)methyl)piperazin-1-yl)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05629 Protein cereblon Homo sapiens 1280 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=535918 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=535918&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 156403274 464921100 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 238007 O=C1CCC(N2Cc3cc(CN4CC5CC4CN5C(=O)c4ccccc4-c4ccc(Cl)cc4)ccc3C2=O)C(=O)N1 InChI=1S/C32H29ClN4O4/c33-22-8-6-20(7-9-22)25-3-1-2-4-27(25)32(41)36-18-23-14-24(36)17-35(23)15-19-5-10-26-21(13-19)16-37(31(26)40)28-11-12-29(38)34-30(28)39/h1-10,13,23-24,28H,11-12,14-18H2,(H,34,38,39) IIZVNECBIUOFIN-UHFFFAOYSA-N 535919 3-(5-((5-(4'-chloro-[1,1'-biphenyl]-2- carbonyl)-2,5-diazabicyclo[2.2.1]heptan-2- yl)methyl)-1-oxoisoindolin-2-yl)piperidine- 2,6-dione::US20260028326, Compound GT-05776 Protein cereblon Homo sapiens 420 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=535919 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=535919&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 156403279 464921101 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 238008 CC1(C)CCC(CN2CC3CN(C(=O)c4ccc5c(c4)CN(C4CCC(=O)NC4=O)C5=O)CC3C2)=C(c2ccc(F)cc2)C1 InChI=1S/C35H39FN4O4/c1-35(2)12-11-23(29(14-35)21-3-6-27(36)7-4-21)15-38-16-25-18-39(19-26(25)17-38)33(43)22-5-8-28-24(13-22)20-40(34(28)44)30-9-10-31(41)37-32(30)42/h3-8,13,25-26,30H,9-12,14-20H2,1-2H3,(H,37,41,42) ULJLVQCLLVIQTQ-UHFFFAOYSA-N 535920 3-(5-(5-((4'-fluoro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2- yl)methyl)octahydropyrrolo[3,4-c]pyrrole- 2-carbonyl)-1-oxoisoindolin-2- yl)piperidine-2,6-dione::US20260028326, Compound GT-05447 Protein cereblon Homo sapiens 1150 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=535920 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=535920&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 155047166 464921102 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 238009 O=C1CCC(N2Cc3cc(C(=O)N4CCN(Cc5cccc(-c6ccc(Cl)cc6)c5)CC4)ccc3C2=O)C(=O)N1 InChI=1S/C31H29ClN4O4/c32-25-7-4-21(5-8-25)22-3-1-2-20(16-22)18-34-12-14-35(15-13-34)30(39)23-6-9-26-24(17-23)19-36(31(26)40)27-10-11-28(37)33-29(27)38/h1-9,16-17,27H,10-15,18-19H2,(H,33,37,38) RVVYYDXFRDLGEY-UHFFFAOYSA-N 535921 5-(4-((4'-chloro-[1,1'-biphenyl]-3- yl)methyl)piperazine-1-carbonyl)-2-(2,6- dioxopiperidin-3-yl)isoindoline-1,3-dione::US20260028326, Compound GT-05631 Protein cereblon Homo sapiens 1750 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=535921 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=535921&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 155047238 464921103 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 238010 O=C1CCC(N2Cc3cc(CN4CCN(Cc5ncccc5-c5ccc(Cl)cc5)CC4)ccc3C2=O)C(=O)N1 InChI=1S/C30H30ClN5O3/c31-23-6-4-21(5-7-23)24-2-1-11-32-26(24)19-35-14-12-34(13-15-35)17-20-3-8-25-22(16-20)18-36(30(25)39)27-9-10-28(37)33-29(27)38/h1-8,11,16,27H,9-10,12-15,17-19H2,(H,33,37,38) GLSKOICTNLUADC-UHFFFAOYSA-N 535923 3-(5-((4-((3-(4-chlorophenyl)pyridin-2- yl)methyl)piperazin-1-yl)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05778 Protein cereblon Homo sapiens 560 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=535923 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=535923&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 153283791 464921105 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 238011 O=C1CCC(N2Cc3cc(C(=O)N4CCN(C(=O)C5=C(c6ccc(F)cc6)CCCC5)CC4)ccc3C2=O)C(=O)N1 InChI=1S/C31H31FN4O5/c32-22-8-5-19(6-9-22)23-3-1-2-4-25(23)30(40)35-15-13-34(14-16-35)29(39)20-7-10-24-21(17-20)18-36(31(24)41)26-11-12-27(37)33-28(26)38/h5-10,17,26H,1-4,11-16,18H2,(H,33,37,38) LRLUKMLZFGGXES-UHFFFAOYSA-N 535924 3-(5-(4-(4'-fluoro-3,4,5,6-tetrahydro-[1,1'- biphenyl]-2-carbonyl)piperazine-1- carbonyl)-1-oxoisoindolin-2-yl)piperidine- 2,6-dione::US20260028326, Compound GT-05448 Protein cereblon Homo sapiens 1390 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=535924 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=535924&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 153283936 464921106 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 238012 O=C1CCC(N2Cc3cc(CN4CCN(Cc5ccc(-c6ccc(Cl)cc6)nc5)CC4)ccc3C2=O)C(=O)N1 InChI=1S/C30H30ClN5O3/c31-24-5-3-22(4-6-24)26-8-2-21(16-32-26)18-35-13-11-34(12-14-35)17-20-1-7-25-23(15-20)19-36(30(25)39)27-9-10-28(37)33-29(27)38/h1-8,15-16,27H,9-14,17-19H2,(H,33,37,38) NATHXNZNBBABEU-UHFFFAOYSA-N 535925 3-(5-((4-((6-(4-chlorophenyl)pyridin-3- yl)methyl)piperazin-1-yl)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05632 Protein cereblon Homo sapiens 720 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=535925 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=535925&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 153407164 464921107 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 238013 O=C1CCC(N2Cc3cc(CN4CCN(Cc5ccccc5-c5cccs5)CC4)ccc3C2=O)C(=O)N1 InChI=1S/C29H30N4O3S/c34-27-10-9-25(28(35)30-27)33-19-22-16-20(7-8-24(22)29(33)36)17-31-11-13-32(14-12-31)18-21-4-1-2-5-23(21)26-6-3-15-37-26/h1-8,15-16,25H,9-14,17-19H2,(H,30,34,35) WDFCHPFDVXNXDX-UHFFFAOYSA-N 535926 3-(5-((4-(2-(furan-2-yl)benzyl)piperazin-1- yl)methyl)-1-oxoisoindolin-2-yl)piperidine- 2,6-dione::US20260028326, Compound GT-05779 Protein cereblon Homo sapiens 430 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=535926 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=535926&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 156403363 464921108 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 238014 O=C1CCC(N2Cc3cc(C(=O)N4C5CC4CN(C(=O)C4=C(c6ccc(F)cc6)CCCC4)C5)ccc3C2=O)C(=O)N1 InChI=1S/C32H31FN4O5/c33-21-8-5-18(6-9-21)24-3-1-2-4-26(24)31(41)35-16-22-14-23(17-35)37(22)30(40)19-7-10-25-20(13-19)15-36(32(25)42)27-11-12-28(38)34-29(27)39/h5-10,13,22-23,27H,1-4,11-12,14-17H2,(H,34,38,39) JTGHXZPLEOJGSH-UHFFFAOYSA-N 535927 3-(5-(3-(4'-fluoro-3,4,5,6-tetrahydro-[1,1'- biphenyl]-2-carbonyl)-3,6- diazabicyclo[3.1.1]heptane-6-carbonyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05449 Protein cereblon Homo sapiens 1690 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=535927 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=535927&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 147365114 464921109 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 238015 O=C1CCC(N2Cc3cc(CN4CCN(Cc5ccc(-c6ccncc6)nc5)CC4)ccc3C2=O)C(=O)N1 InChI=1S/C29H30N6O3/c36-27-6-5-26(28(37)32-27)35-19-23-15-20(1-3-24(23)29(35)38)17-33-11-13-34(14-12-33)18-21-2-4-25(31-16-21)22-7-9-30-10-8-22/h1-4,7-10,15-16,26H,5-6,11-14,17-19H2,(H,32,36,37) RHEXGFYDQGAJFQ-UHFFFAOYSA-N 535928 3-(5-((4-([2,4'-bipyridin]-5- ylmethyl)piperazin-1-yl)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05633 Protein cereblon Homo sapiens 760 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=535928 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=535928&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 155047460 464921110 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 238016 O=C1CCC(N2Cc3cc(CN4CCN(Cc5ccc(-c6ccco6)s5)CC4)ccc3C2=O)C(=O)N1 InChI=1S/C27H28N4O4S/c32-25-8-6-22(26(33)28-25)31-16-19-14-18(3-5-21(19)27(31)34)15-29-9-11-30(12-10-29)17-20-4-7-24(36-20)23-2-1-13-35-23/h1-5,7,13-14,22H,6,8-12,15-17H2,(H,28,32,33) SBBONJADBCQJFC-UHFFFAOYSA-N 535929 3-(5-((4-((5-(furan-2-yl)thiophen-2- yl)methyl)piperazin-1-yl)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05780 Protein cereblon Homo sapiens 230 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=535929 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=535929&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 138491386 464921111 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 238017 CC1(C)CCC(CN2CC3CC(C2)N3C(=O)c2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)=C(c2ccc(F)cc2)C1 InChI=1S/C34H37FN4O4/c1-34(2)12-11-22(28(15-34)20-3-6-24(35)7-4-20)16-37-18-25-14-26(19-37)39(25)32(42)21-5-8-27-23(13-21)17-38(33(27)43)29-9-10-30(40)36-31(29)41/h3-8,13,25-26,29H,9-12,14-19H2,1-2H3,(H,36,40,41) MXWODZPBVNSOMW-UHFFFAOYSA-N 535931 3-(5-(3-((4'-fluoro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-yl)methyl)- 3,6-diazabicyclo[3.1.1]heptane-6- carbonyl)-1-oxoisoindolin-2-yl)piperidine- 2,6-dione::US20260028326, Compound GT-05450 Protein cereblon Homo sapiens 890 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=535931 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=535931&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 163407711 464921113 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 238018 O=C1CCC(N2Cc3cc(CN4CCN(C(=O)c5cnc(-c6ccccc6)cn5)CC4)ccc3C2=O)C(=O)N1 InChI=1S/C29H28N6O4/c36-26-9-8-25(27(37)32-26)35-18-21-14-19(6-7-22(21)28(35)38)17-33-10-12-34(13-11-33)29(39)24-16-30-23(15-31-24)20-4-2-1-3-5-20/h1-7,14-16,25H,8-13,17-18H2,(H,32,36,37) SCWRSEKKURCXQA-UHFFFAOYSA-N 535932 3-(1-oxo-5-((4-(5-phenylpyrazine-2- carbonyl)piperazin-1-yl)methyl)isoindolin- 2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05635 Protein cereblon Homo sapiens 1000 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=535932 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=535932&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 138491405 464921114 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 238019 CC1(C)CCC(CN2CC3CCC2CN3Cc2cc(F)c3c(c2)CN(C2CCC(=O)NC2=O)C3=O)=C(c2ccc(Cl)cc2)C1 InChI=1S/C35H40ClFN4O3/c1-35(2)12-11-23(28(15-35)22-3-5-25(36)6-4-22)17-40-20-26-7-8-27(40)19-39(26)16-21-13-24-18-41(34(44)32(24)29(37)14-21)30-9-10-31(42)38-33(30)43/h3-6,13-14,26-27,30H,7-12,15-20H2,1-2H3,(H,38,42,43) RIJIDSVOGSRINU-UHFFFAOYSA-N 535933 3-(5-((5-((4'-chloro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-yl)methyl)- 2,5-diazabicyclo[2.2.2]octan-2-yl)methyl)- 7-fluoro-1-oxoisoindolin-2-yl)piperidine- 2,6-dione::US20260028326, Compound GT-05781 Protein cereblon Homo sapiens 710 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=535933 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=535933&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 156403366 464921115 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 238020 CC1(C)CCC(CN2CC3CCC(C2)N3C(=O)c2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)=C(c2ccc(F)cc2)C1 InChI=1S/C35H39FN4O4/c1-35(2)14-13-23(29(16-35)21-3-6-25(36)7-4-21)17-38-19-26-8-9-27(20-38)40(26)33(43)22-5-10-28-24(15-22)18-39(34(28)44)30-11-12-31(41)37-32(30)42/h3-7,10,15,26-27,30H,8-9,11-14,16-20H2,1-2H3,(H,37,41,42) RJOXAMRBYJQUDD-UHFFFAOYSA-N 535934 3-(5-(3-((4'-fluoro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-yl)methyl)- 3,8-diazabicyclo[3.2.1]octane-8-carbonyl)- 1-oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05451 Protein cereblon Homo sapiens 1160 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=535934 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=535934&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 153407171 464921116 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 238021 O=C1CCC(N2Cc3cc(C(=O)N4CC5(CN(Cc6ccccc6-c6ccc(Cl)cc6)C5)C4)ccc3C2=O)C(=O)N1 InChI=1S/C32H29ClN4O4/c33-24-8-5-20(6-9-24)25-4-2-1-3-22(25)14-35-16-32(17-35)18-36(19-32)30(40)21-7-10-26-23(13-21)15-37(31(26)41)27-11-12-28(38)34-29(27)39/h1-10,13,27H,11-12,14-19H2,(H,34,38,39) YVCFVKBNQUCHPT-UHFFFAOYSA-N 535935 3-(5-(6-((4'-chloro-[1,1'-biphenyl]-2- yl)methyl)-2,6-diazaspiro[3.3]heptane-2- carbonyl)-1-oxoisoindolin-2-yl)piperidine- 2,6-dione::US20260028326, Compound GT-05637 Protein cereblon Homo sapiens 1070 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=535935 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=535935&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 138491387 464921117 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 238022 CC1(C)CCC(CN2CCC(Nc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)CC2)=C(c2ccc(Cl)cc2)C1 InChI=1S/C33H39ClN4O3/c1-33(2)14-11-22(28(18-33)21-3-5-24(34)6-4-21)19-37-15-12-25(13-16-37)35-26-7-8-27-23(17-26)20-38(32(27)41)29-9-10-30(39)36-31(29)40/h3-8,17,25,29,35H,9-16,18-20H2,1-2H3,(H,36,39,40) OMFJCWCSSCGHNB-UHFFFAOYSA-N 535936 3-(5-((1-((4'-chloro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2- yl)methyl)piperidin-4-yl)amino)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05782 Protein cereblon Homo sapiens 1760 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=535936 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=535936&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 153283806 464921118 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 238023 CC1(C)CCC(CN2CC3CC2CN3C(=O)c2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)=C(c2ccc(F)cc2)C1 InChI=1S/C34H37FN4O4/c1-34(2)12-11-22(28(15-34)20-3-6-24(35)7-4-20)16-37-18-26-14-25(37)19-38(26)32(42)21-5-8-27-23(13-21)17-39(33(27)43)29-9-10-30(40)36-31(29)41/h3-8,13,25-26,29H,9-12,14-19H2,1-2H3,(H,36,40,41) JZEICFVQEJWDJQ-UHFFFAOYSA-N 535937 3-(5-(5-((4'-fluoro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-yl)methyl)- 2,5-diazabicyclo[2.2.1]heptane-2- carbonyl)-1-oxoisoindolin-2-yl)piperidine- 2,6-dione::US20260028326, Compound GT-05452 Protein cereblon Homo sapiens 440 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=535937 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=535937&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 163407712 464921119 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 238024 O=C1CCC(N2Cc3cc(C(=O)N4C5CCC4CN(Cc4ccccc4-c4ccc(Cl)cc4)C5)ccc3C2=O)C(=O)N1 InChI=1S/C33H31ClN4O4/c34-24-8-5-20(6-9-24)27-4-2-1-3-22(27)16-36-18-25-10-11-26(19-36)38(25)32(41)21-7-12-28-23(15-21)17-37(33(28)42)29-13-14-30(39)35-31(29)40/h1-9,12,15,25-26,29H,10-11,13-14,16-19H2,(H,35,39,40) PKNRJYQPADTBQG-UHFFFAOYSA-N 535938 3-(5-(3-((4'-chloro-[1,1'-biphenyl]-2- yl)methyl)-3,8-diazabicyclo[3.2.1]octane- 8-carbonyl)-1-oxoisoindolin-2- yl)piperidine-2,6-dione::US20260028326, Compound GT-05638 Protein cereblon Homo sapiens 1210 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=535938 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=535938&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 156403302 464921120 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 238025 CC1(C)CCC(C(=O)N2CCC(Nc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)CC2)=C(c2ccc(Cl)cc2)C1 InChI=1S/C33H37ClN4O4/c1-33(2)14-11-26(27(18-33)20-3-5-22(34)6-4-20)31(41)37-15-12-23(13-16-37)35-24-7-8-25-21(17-24)19-38(32(25)42)28-9-10-29(39)36-30(28)40/h3-8,17,23,28,35H,9-16,18-19H2,1-2H3,(H,36,39,40) INUZPLUAYDZXMA-UHFFFAOYSA-N 535940 3-(5-((1-(4'-chloro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2- carbonyl)piperidin-4-yl)amino)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05783 Protein cereblon Homo sapiens 940 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=535940 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=535940&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 156403324 464921121 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 238026 CC1(C)CCC(CN2CCCN(C(=O)c3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)CC2)=C(c2ccc(Cl)cc2)C1 InChI=1S/C34H39ClN4O4/c1-34(2)13-12-24(28(19-34)22-4-7-26(35)8-5-22)20-37-14-3-15-38(17-16-37)32(42)23-6-9-27-25(18-23)21-39(33(27)43)29-10-11-30(40)36-31(29)41/h4-9,18,29H,3,10-17,19-21H2,1-2H3,(H,36,40,41) VBUHXGLFLONQPV-UHFFFAOYSA-N 535941 3-(5-(4-((4'-chloro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-yl)methyl)- 1,4-diazepane-1-carbonyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05453 Protein cereblon Homo sapiens 1240 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=535941 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=535941&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 163407713 464921122 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 238027 O=C1CCC(N2Cc3cc(C(=O)N4CC5CC4CN5C(=O)c4ccccc4-c4ccc(Cl)cc4)ccc3C2=O)C(=O)N1 InChI=1S/C32H27ClN4O5/c33-21-8-5-18(6-9-21)24-3-1-2-4-26(24)32(42)36-17-22-14-23(36)16-35(22)30(40)19-7-10-25-20(13-19)15-37(31(25)41)27-11-12-28(38)34-29(27)39/h1-10,13,22-23,27H,11-12,14-17H2,(H,34,38,39) HZNQPQLEAJFYJK-UHFFFAOYSA-N 535942 3-(5-(5-((4'-chloro-[1,1'-biphenyl]-2- yl)methyl)-2,6-diazabicyclo[2.2.1]heptane- 2-carbonyl)-1-oxoisoindolin-2- yl)piperidine-2,6-dione::US20260028326, Compound GT-05639 Protein cereblon Homo sapiens 780 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=535942 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=535942&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 156403337 464921123 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 238028 O=C1CCC(N2Cc3cc(NC4CCN(C(=O)c5ccccc5-c5ccc(Cl)cc5)CC4)ccc3C2=O)C(=O)N1 InChI=1S/C31H29ClN4O4/c32-21-7-5-19(6-8-21)24-3-1-2-4-26(24)30(39)35-15-13-22(14-16-35)33-23-9-10-25-20(17-23)18-36(31(25)40)27-11-12-28(37)34-29(27)38/h1-10,17,22,27,33H,11-16,18H2,(H,34,37,38) BSYXVNCXIBNGKQ-UHFFFAOYSA-N 535943 3-(5-((1-(4'-chloro-[1,1'-biphenyl]-2- carbonyl)piperidin-4-yl)amino)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05784 Protein cereblon Homo sapiens 620 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=535943 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=535943&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 156403276 464921124 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 238029 O=C1CCC(N2Cc3cc(C(=O)N4CCN(Cc5ccccc5-c5ccc(Cl)cc5)CC4)ccc3C2=O)C(=O)N1 InChI=1S/C31H29ClN4O4/c32-24-8-5-20(6-9-24)25-4-2-1-3-22(25)18-34-13-15-35(16-14-34)30(39)21-7-10-26-23(17-21)19-36(31(26)40)27-11-12-28(37)33-29(27)38/h1-10,17,27H,11-16,18-19H2,(H,33,37,38) LLQQPKDATQXWOD-UHFFFAOYSA-N 535944 3-(5-(4-((4'-chloro-[1,1'-biphenyl]-2- yl)methyl)piperazine-1-carbonyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05455 Protein cereblon Homo sapiens 1070 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=535944 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=535944&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 156403371 464921125 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 238030 O=C1CCC(N2Cc3cc(CN4CCN(Cc5cccc(-c6ccco6)c5)CC4)ccc3C2=O)C(=O)N1 InChI=1S/C29H30N4O4/c34-27-9-8-25(28(35)30-27)33-19-23-16-21(6-7-24(23)29(33)36)18-32-12-10-31(11-13-32)17-20-3-1-4-22(15-20)26-5-2-14-37-26/h1-7,14-16,25H,8-13,17-19H2,(H,30,34,35) KORDRMSQMGVWTP-UHFFFAOYSA-N 535945 3-(5-((4-(3-(furan-2-yl)benzyl)piperazin-1- yl)methyl)-1-oxoisoindolin-2-yl)piperidine- 2,6-dione::US20260028326, Compound GT-05692 Protein cereblon Homo sapiens 470 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=535945 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=535945&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 156403333 464921126 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 238031 CC1(C)CCC(CN2CCC(Nc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)CC2)=C(c2ccc(F)cc2)C1 InChI=1S/C33H39FN4O3/c1-33(2)14-11-22(28(18-33)21-3-5-24(34)6-4-21)19-37-15-12-25(13-16-37)35-26-7-8-27-23(17-26)20-38(32(27)41)29-9-10-30(39)36-31(29)40/h3-8,17,25,29,35H,9-16,18-20H2,1-2H3,(H,36,39,40) CTUDDWPRAGWZQL-UHFFFAOYSA-N 535946 3-(5-((1-(4'-fluoro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2- yl)methyl)piperidin-4-yl)amino)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05785 Protein cereblon Homo sapiens 1250 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=535946 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=535946&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 156403307 464921127 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 238032 CC1(C)CCC(CN2C3CC2CN(C(=O)c2ccc4c(c2)CN(C2CCC(=O)NC2=O)C4=O)C3)=C(c2ccc(Cl)cc2)C1 InChI=1S/C34H37ClN4O4/c1-34(2)12-11-22(28(15-34)20-3-6-24(35)7-4-20)16-38-25-14-26(38)19-37(18-25)32(42)21-5-8-27-23(13-21)17-39(33(27)43)29-9-10-30(40)36-31(29)41/h3-8,13,25-26,29H,9-12,14-19H2,1-2H3,(H,36,40,41) CUPSZVWBCDNVED-UHFFFAOYSA-N 535947 3-(5-(6-((4'-chloro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-yl)methyl)- 3,6-diazabicyclo[3.1.1]heptane-3- carbonyl)-1-oxoisoindolin-2-yl)piperidine- 2,6-dione::US20260028326, Compound GT-05457 Protein cereblon Homo sapiens 1260 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=535947 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=535947&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 163407714 464921128 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 238033 O=C1CCC(N2Cc3cc(CN4CCN(Cc5ccc(-c6ccco6)cc5)CC4)ccc3C2=O)C(=O)N1 InChI=1S/C29H30N4O4/c34-27-10-9-25(28(35)30-27)33-19-23-16-21(5-8-24(23)29(33)36)18-32-13-11-31(12-14-32)17-20-3-6-22(7-4-20)26-2-1-15-37-26/h1-8,15-16,25H,9-14,17-19H2,(H,30,34,35) KHTDGKVJTZGOHZ-UHFFFAOYSA-N 535948 3-(5-((4-(4-(furan-2-yl)benzyl)piperazin-1- yl)methyl)-1-oxoisoindolin-2-yl)piperidine- 2,6-dione::US20260028326, Compound GT-05693 Protein cereblon Homo sapiens 310 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=535948 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=535948&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 138491385 464921129 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 238034 CC1(C)CCC(C(=O)N2CCC(Nc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)CC2)=C(c2ccc(F)cc2)C1 InChI=1S/C33H37FN4O4/c1-33(2)14-11-26(27(18-33)20-3-5-22(34)6-4-20)31(41)37-15-12-23(13-16-37)35-24-7-8-25-21(17-24)19-38(32(25)42)28-9-10-29(39)36-30(28)40/h3-8,17,23,28,35H,9-16,18-19H2,1-2H3,(H,36,39,40) GKNPJYNCKOFQJF-UHFFFAOYSA-N 535949 3-(5-((1-(4'-fluoro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2- carbonyl)piperidin-4-yl)amino)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05786 Protein cereblon Homo sapiens 1070 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=535949 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=535949&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 163407715 464921130 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 238035 CC1(C)CCC(CN2CC3CCC(C2)N3C(=O)c2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)=C(c2ccc(Cl)cc2)C1 InChI=1S/C35H39ClN4O4/c1-35(2)14-13-23(29(16-35)21-3-6-25(36)7-4-21)17-38-19-26-8-9-27(20-38)40(26)33(43)22-5-10-28-24(15-22)18-39(34(28)44)30-11-12-31(41)37-32(30)42/h3-7,10,15,26-27,30H,8-9,11-14,16-20H2,1-2H3,(H,37,41,42) YHTVSGFBZZAFFX-UHFFFAOYSA-N 535950 3-(5-(3-((4'-chloro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-yl)methyl)- 3,8-diazaspiro[3.2.1]octane-8-carbonyl)- 1-oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05458 Protein cereblon Homo sapiens 1410 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=535950 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=535950&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 163407716 464921131 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 238036 O=C1CCC(N2Cc3cc(CN4CCN(Cc5ccc(-c6ccco6)o5)CC4)ccc3C2=O)C(=O)N1 InChI=1S/C27H28N4O5/c32-25-8-6-22(26(33)28-25)31-16-19-14-18(3-5-21(19)27(31)34)15-29-9-11-30(12-10-29)17-20-4-7-24(36-20)23-2-1-13-35-23/h1-5,7,13-14,22H,6,8-12,15-17H2,(H,28,32,33) TXPSYPYJPKJOOH-UHFFFAOYSA-N 535952 3-(5-((4-([2,2'-bifuran]-5- ylmethyl)piperazin-1-yl)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05695 Protein cereblon Homo sapiens 250 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=535952 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=535952&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 163407718 464921133 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 238037 O=C1CCC(N2Cc3c(CN4CCC(Nc5ccccc5-c5ccc(Cl)cc5)CC4)cccc3C2=O)C(=O)N1 InChI=1S/C31H31ClN4O3/c32-22-10-8-20(9-11-22)24-5-1-2-7-27(24)33-23-14-16-35(17-15-23)18-21-4-3-6-25-26(21)19-36(31(25)39)28-12-13-29(37)34-30(28)38/h1-11,23,28,33H,12-19H2,(H,34,37,38) GVPMBKXDTPMGRK-UHFFFAOYSA-N 535955 3-(4-((4-((4'-chloro-[1,1'-biphenyl]-2- yl)amino)piperidin-1-yl)methyl)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-04947 Protein cereblon Homo sapiens 390 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=535955 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=535955&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 156403340 464921136 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 238038 CC1(C)CCC(CN2CC3CCC(C2)N3Cc2ccc3c(c2)C(=O)N(C2CCC(=O)NC2=O)C3)=C(c2ccc(Cl)cc2)C1 InChI=1S/C35H41ClN4O3/c1-35(2)14-13-25(30(16-35)23-5-7-26(36)8-6-23)18-38-20-27-9-10-28(21-38)39(27)17-22-3-4-24-19-40(34(43)29(24)15-22)31-11-12-32(41)37-33(31)42/h3-8,15,27-28,31H,9-14,16-21H2,1-2H3,(H,37,41,42) PLIXUQPQLRQZRL-UHFFFAOYSA-N 535956 3-(6-((3-(4'-chloro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-yl)methyl)- 3,8-diazabicyclo[3.2.1]octan-8-yl)methyl)- 1-oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05459 Protein cereblon Homo sapiens 1120 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=535956 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=535956&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 163407721 464921137 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 238039 O=C1CCC(N2C(=O)c3ccc(CN4CCN(Cc5ccncc5-c5ccc(Cl)cc5)CC4)cc3C2=O)C(=O)N1 InChI=1S/C30H28ClN5O4/c31-22-4-2-20(3-5-22)25-16-32-10-9-21(25)18-35-13-11-34(12-14-35)17-19-1-6-23-24(15-19)30(40)36(29(23)39)26-7-8-27(37)33-28(26)38/h1-6,9-10,15-16,26H,7-8,11-14,17-18H2,(H,33,37,38) RKWOQCRGZMZOIN-UHFFFAOYSA-N 535958 5-((4-((3-(4-chlorophenyl)pyridin-4- yl)methyl)piperazin-1-yl)methyl)-2-(2,6- dioxopiperidin-3-yl)isoindoline-1,3-dione::US20260028326, Compound GT-05731 Protein cereblon Homo sapiens 1650 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=535958 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=535958&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 149534455 464921139 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 238040 O=C1CCC(N2Cc3cc(NC4CN(C(=O)c5ccccc5-c5ccc(Cl)cc5)C4)ccc3C2=O)C(=O)N1 InChI=1S/C29H25ClN4O4/c30-19-7-5-17(6-8-19)22-3-1-2-4-24(22)28(37)33-15-21(16-33)31-20-9-10-23-18(13-20)14-34(29(23)38)25-11-12-26(35)32-27(25)36/h1-10,13,21,25,31H,11-12,14-16H2,(H,32,35,36) PGUGBVPIPNATNL-UHFFFAOYSA-N 535959 3-(5-((1-(4'-chloro-[1,1'-biphenyl]-2- carbonyl)azetidin-3-yl)amino)-1- oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-04397 Protein cereblon Homo sapiens 200 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=535959 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=535959&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 163407723 464921140 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4 238041 CC1(C)CCC(CN2CC3CCC2CN3Cc2cccc3c2CN(C2CCC(=O)NC2=O)C3=O)=C(c2ccc(Cl)cc2)C1 InChI=1S/C35H41ClN4O3/c1-35(2)15-14-24(29(16-35)22-6-8-25(36)9-7-22)18-39-20-26-10-11-27(39)19-38(26)17-23-4-3-5-28-30(23)21-40(34(28)43)31-12-13-32(41)37-33(31)42/h3-9,26-27,31H,10-21H2,1-2H3,(H,37,41,42) ZDTGNLBVQKTYKA-UHFFFAOYSA-N 535960 3-(4-((5-((4'-chloro-5,5-dimethyl-3,4,5,6- tetrahydro-[1,1'-biphenyl]-2-yl)methyl)- 2,5-diazabicyclo[2.2.2]octan-2-yl)methyl)- 1-oxoisoindolin-2-yl)piperidine-2,6-dione::US20260028326, Compound GT-05461 Protein cereblon Homo sapiens 1580 US Patent 10.7270/Q2G44W3Z US20260028326 YANG, X; SUN, R; ZHOU, Y; ZHAO, B 1/29/2026 6/10/2026 Gluetacs Therapeutics (Shanghai) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=535960 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007050&target=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=535960&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search 156403344 464921141 1 MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL 9NWT,9NWS,9DUR,8TNR,8TNQ,8TNP,9SQ6,9SQ5,9SQ4,9DWW,9DWV,9Q33,9OUK,9NGT,9NFR,9NFQ,8D81,8D80,8D7Z,8D7Y,8D7X,8D7W,8D7V,8D7U,8CVP,9YA9,9Q2D,9Q03,9DQD,8UH6,9SAI,9SAF,9H59,9E2U,6BOY,6BNB,6BN9,6BN8,6BN7,9OUL,9Y7D,6XK9,6UML,5V3O,5HXB,9NYR,9HNE,9D0X,9D0W,7U8F,9FJX,8OJH,8OIZ,11MR,10AY,9V0F,9V0B,9V0A,9UUM,9NR3,9HPJ,9HPI,7LPS,9SFM,9OTY,4TZ4,9W2F,9OS2,9DJX,9DJT,8U17,8U16,8U15,8TZX,8DEY,9CUO,4M91 Protein cereblon CRBN_HUMAN Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4