BindingDB Reactant_set_id	Ligand SMILES	Ligand InChI	Ligand InChI Key	BindingDB MonomerID	BindingDB Ligand Name	Target Name	Target Source Organism According to Curator or DataSource	Ki (nM)	IC50 (nM)	Kd (nM)	EC50 (nM)	kon (M-1-s-1)	koff (s-1)	pH	Temp (C)	Curation/DataSource	Article DOI	BindingDB Entry DOI	PMID	PubChem AID	Patent Number	Authors	Date of publication	Date in BindingDB	Institution	Link to Ligand in BindingDB	Link to Target in BindingDB	Link to Ligand-Target Pair in BindingDB	Ligand HET ID in PDB	PDB ID(s) for Ligand-Target Complex	PubChem CID	PubChem SID	ChEBI ID of Ligand	ChEMBL ID of Ligand	DrugBank ID of Ligand	IUPHAR_GRAC ID of Ligand	KEGG ID of Ligand	ZINC ID of Ligand	Number of Protein Chains in Target (>1 implies a multichain complex)	BindingDB Target Chain Sequence 1	PDB ID(s) of Target Chain 1	UniProt (SwissProt) Recommended Name of Target Chain 1	UniProt (SwissProt) Entry Name of Target Chain 1	UniProt (SwissProt) Primary ID of Target Chain 1	UniProt (SwissProt) Secondary ID(s) of Target Chain 1	UniProt (SwissProt) Alternative ID(s) of Target Chain 1	UniProt (TrEMBL) Submitted Name of Target Chain 1	UniProt (TrEMBL) Entry Name of Target Chain 1	UniProt (TrEMBL) Primary ID of Target Chain 1	UniProt (TrEMBL) Secondary ID(s) of Target Chain 1	UniProt (TrEMBL) Alternative ID(s) of Target Chain 1	BindingDB Target Chain Sequence 2	PDB ID(s) of Target Chain 2	UniProt (SwissProt) Recommended Name of Target Chain 2	UniProt (SwissProt) Entry Name of Target Chain 2	UniProt (SwissProt) Primary ID of Target Chain 2	UniProt (SwissProt) Secondary ID(s) of Target Chain 2	UniProt (SwissProt) Alternative ID(s) of Target Chain 2	UniProt (TrEMBL) Submitted Name of Target Chain 2	UniProt (TrEMBL) Entry Name of Target Chain 2	UniProt (TrEMBL) Primary ID of Target Chain 2	UniProt (TrEMBL) Secondary ID(s) of Target Chain 2	UniProt (TrEMBL) Alternative ID(s) of Target Chain 2	BindingDB Target Chain Sequence 3	PDB ID(s) of Target Chain 3	UniProt (SwissProt) Recommended Name of Target Chain 3	UniProt (SwissProt) Entry Name of Target Chain 3	UniProt (SwissProt) Primary ID of Target Chain 3	UniProt (SwissProt) Secondary ID(s) of Target Chain 3	UniProt (SwissProt) Alternative ID(s) of Target Chain 3	UniProt (TrEMBL) Submitted Name of Target Chain 3	UniProt (TrEMBL) Entry Name of Target Chain 3	UniProt (TrEMBL) Primary ID of Target Chain 3	UniProt (TrEMBL) Secondary ID(s) of Target Chain 3	UniProt (TrEMBL) Alternative ID(s) of Target Chain 3	BindingDB Target Chain Sequence 4	PDB ID(s) of Target Chain 4	UniProt (SwissProt) Recommended Name of Target Chain 4	UniProt (SwissProt) Entry Name of Target Chain 4	UniProt (SwissProt) Primary ID of Target Chain 4	UniProt (SwissProt) Secondary ID(s) of Target Chain 4	UniProt (SwissProt) Alternative ID(s) of Target Chain 4	UniProt (TrEMBL) Submitted Name of Target Chain 4	UniProt (TrEMBL) Entry Name of Target Chain 4	UniProt (TrEMBL) Primary ID of Target Chain 4	UniProt (TrEMBL) Secondary ID(s) of Target Chain 4	UniProt (TrEMBL) Alternative ID(s) of Target Chain 4	BindingDB Target Chain Sequence 5	PDB ID(s) of Target Chain 5	UniProt (SwissProt) Recommended Name of Target Chain 5	UniProt (SwissProt) Entry Name of Target Chain 5	UniProt (SwissProt) Primary ID of Target Chain 5	UniProt (SwissProt) Secondary ID(s) of Target Chain 5	UniProt (SwissProt) Alternative ID(s) of Target Chain 5	UniProt (TrEMBL) Submitted Name of Target Chain 5	UniProt (TrEMBL) Entry Name of Target Chain 5	UniProt (TrEMBL) Primary ID of Target Chain 5	UniProt (TrEMBL) Secondary ID(s) of Target Chain 5	UniProt (TrEMBL) Alternative ID(s) of Target Chain 5	BindingDB Target Chain Sequence 6	PDB ID(s) of Target Chain 6	UniProt (SwissProt) Recommended Name of Target Chain 6	UniProt (SwissProt) Entry Name of Target Chain 6	UniProt (SwissProt) Primary ID of Target Chain 6	UniProt (SwissProt) Secondary ID(s) of Target Chain 6	UniProt (SwissProt) Alternative ID(s) of Target Chain 6	UniProt (TrEMBL) Submitted Name of Target Chain 6	UniProt (TrEMBL) Entry Name of Target Chain 6	UniProt (TrEMBL) Primary ID of Target Chain 6	UniProt (TrEMBL) Secondary ID(s) of Target Chain 6	UniProt (TrEMBL) Alternative ID(s) of Target Chain 6	BindingDB Target Chain Sequence 7	PDB ID(s) of Target Chain 7	UniProt (SwissProt) Recommended Name of Target Chain 7	UniProt (SwissProt) Entry Name of Target Chain 7	UniProt (SwissProt) Primary ID of Target Chain 7	UniProt (SwissProt) Secondary ID(s) of Target Chain 7	UniProt (SwissProt) Alternative ID(s) of Target Chain 7	UniProt (TrEMBL) Submitted Name of Target Chain 7	UniProt (TrEMBL) Entry Name of Target Chain 7	UniProt (TrEMBL) Primary ID of Target Chain 7	UniProt (TrEMBL) Secondary ID(s) of Target Chain 7	UniProt (TrEMBL) Alternative ID(s) of Target Chain 7	BindingDB Target Chain Sequence 8	PDB ID(s) of Target Chain 8	UniProt (SwissProt) Recommended Name of Target Chain 8	UniProt (SwissProt) Entry Name of Target Chain 8	UniProt (SwissProt) Primary ID of Target Chain 8	UniProt (SwissProt) Secondary ID(s) of Target Chain 8	UniProt (SwissProt) Alternative ID(s) of Target Chain 8	UniProt (TrEMBL) Submitted Name of Target Chain 8	UniProt (TrEMBL) Entry Name of Target Chain 8	UniProt (TrEMBL) Primary ID of Target Chain 8	UniProt (TrEMBL) Secondary ID(s) of Target Chain 8	UniProt (TrEMBL) Alternative ID(s) of Target Chain 8	BindingDB Target Chain Sequence 9	PDB ID(s) of Target Chain 9	UniProt (SwissProt) Recommended Name of Target Chain 9	UniProt (SwissProt) Entry Name of Target Chain 9	UniProt (SwissProt) Primary ID of Target Chain 9	UniProt (SwissProt) Secondary ID(s) of Target Chain 9	UniProt (SwissProt) Alternative ID(s) of Target Chain 9	UniProt (TrEMBL) Submitted Name of Target Chain 9	UniProt (TrEMBL) Entry Name of Target Chain 9	UniProt (TrEMBL) Primary ID of Target Chain 9	UniProt (TrEMBL) Secondary ID(s) of Target Chain 9	UniProt (TrEMBL) Alternative ID(s) of Target Chain 9	BindingDB Target Chain Sequence 10	PDB ID(s) of Target Chain 10	UniProt (SwissProt) Recommended Name of Target Chain 10	UniProt (SwissProt) Entry Name of Target Chain 10	UniProt (SwissProt) Primary ID of Target Chain 10	UniProt (SwissProt) Secondary ID(s) of Target Chain 10	UniProt (SwissProt) Alternative ID(s) of Target Chain 10	UniProt (TrEMBL) Submitted Name of Target Chain 10	UniProt (TrEMBL) Entry Name of Target Chain 10	UniProt (TrEMBL) Primary ID of Target Chain 10	UniProt (TrEMBL) Secondary ID(s) of Target Chain 10	UniProt (TrEMBL) Alternative ID(s) of Target Chain 10	BindingDB Target Chain Sequence 11	PDB ID(s) of Target Chain 11	UniProt (SwissProt) Recommended Name of Target Chain 11	UniProt (SwissProt) Entry Name of Target Chain 11	UniProt (SwissProt) Primary ID of Target Chain 11	UniProt (SwissProt) Secondary ID(s) of Target Chain 11	UniProt (SwissProt) Alternative ID(s) of Target Chain 11	UniProt (TrEMBL) Submitted Name of Target Chain 11	UniProt (TrEMBL) Entry Name of Target Chain 11	UniProt (TrEMBL) Primary ID of Target Chain 11	UniProt (TrEMBL) Secondary ID(s) of Target Chain 11	UniProt (TrEMBL) Alternative ID(s) of Target Chain 11	BindingDB Target Chain Sequence 12	PDB ID(s) of Target Chain 12	UniProt (SwissProt) Recommended Name of Target Chain 12	UniProt (SwissProt) Entry Name of Target Chain 12	UniProt (SwissProt) Primary ID of Target Chain 12	UniProt (SwissProt) Secondary ID(s) of Target Chain 12	UniProt (SwissProt) Alternative ID(s) of Target Chain 12	UniProt (TrEMBL) Submitted Name of Target Chain 12	UniProt (TrEMBL) Entry Name of Target Chain 12	UniProt (TrEMBL) Primary ID of Target Chain 12	UniProt (TrEMBL) Secondary ID(s) of Target Chain 12	UniProt (TrEMBL) Alternative ID(s) of Target Chain 12	BindingDB Target Chain Sequence 13	PDB ID(s) of Target Chain 13	UniProt (SwissProt) Recommended Name of Target Chain 13	UniProt (SwissProt) Entry Name of Target Chain 13	UniProt (SwissProt) Primary ID of Target Chain 13	UniProt (SwissProt) Secondary ID(s) of Target Chain 13	UniProt (SwissProt) Alternative ID(s) of Target Chain 13	UniProt (TrEMBL) Submitted Name of Target Chain 13	UniProt (TrEMBL) Entry Name of Target Chain 13	UniProt (TrEMBL) Primary ID of Target Chain 13	UniProt (TrEMBL) Secondary ID(s) of Target Chain 13	UniProt (TrEMBL) Alternative ID(s) of Target Chain 13	BindingDB Target Chain Sequence 14	PDB ID(s) of Target Chain 14	UniProt (SwissProt) Recommended Name of Target Chain 14	UniProt (SwissProt) Entry Name of Target Chain 14	UniProt (SwissProt) Primary ID of Target Chain 14	UniProt (SwissProt) Secondary ID(s) of Target Chain 14	UniProt (SwissProt) Alternative ID(s) of Target Chain 14	UniProt (TrEMBL) Submitted Name of Target Chain 14	UniProt (TrEMBL) Entry Name of Target Chain 14	UniProt (TrEMBL) Primary ID of Target Chain 14	UniProt (TrEMBL) Secondary ID(s) of Target Chain 14	UniProt (TrEMBL) Alternative ID(s) of Target Chain 14	BindingDB Target Chain Sequence 15	PDB ID(s) of Target Chain 15	UniProt (SwissProt) Recommended Name of Target Chain 15	UniProt (SwissProt) Entry Name of Target Chain 15	UniProt (SwissProt) Primary ID of Target Chain 15	UniProt (SwissProt) Secondary ID(s) of Target Chain 15	UniProt (SwissProt) Alternative ID(s) of Target Chain 15	UniProt (TrEMBL) Submitted Name of Target Chain 15	UniProt (TrEMBL) Entry Name of Target Chain 15	UniProt (TrEMBL) Primary ID of Target Chain 15	UniProt (TrEMBL) Secondary ID(s) of Target Chain 15	UniProt (TrEMBL) Alternative ID(s) of Target Chain 15	BindingDB Target Chain Sequence 16	PDB ID(s) of Target Chain 16	UniProt (SwissProt) Recommended Name of Target Chain 16	UniProt (SwissProt) Entry Name of Target Chain 16	UniProt (SwissProt) Primary ID of Target Chain 16	UniProt (SwissProt) Secondary ID(s) of Target Chain 16	UniProt (SwissProt) Alternative ID(s) of Target Chain 16	UniProt (TrEMBL) Submitted Name of Target Chain 16	UniProt (TrEMBL) Entry Name of Target Chain 16	UniProt (TrEMBL) Primary ID of Target Chain 16	UniProt (TrEMBL) Secondary ID(s) of Target Chain 16	UniProt (TrEMBL) Alternative ID(s) of Target Chain 16	BindingDB Target Chain Sequence 17	PDB ID(s) of Target Chain 17	UniProt (SwissProt) Recommended Name of Target Chain 17	UniProt (SwissProt) Entry Name of Target Chain 17	UniProt (SwissProt) Primary ID of Target Chain 17	UniProt (SwissProt) Secondary ID(s) of Target Chain 17	UniProt (SwissProt) Alternative ID(s) of Target Chain 17	UniProt (TrEMBL) Submitted Name of Target Chain 17	UniProt (TrEMBL) Entry Name of Target Chain 17	UniProt (TrEMBL) Primary ID of Target Chain 17	UniProt (TrEMBL) Secondary ID(s) of Target Chain 17	UniProt (TrEMBL) Alternative ID(s) of Target Chain 17	BindingDB Target Chain Sequence 18	PDB ID(s) of Target Chain 18	UniProt (SwissProt) Recommended Name of Target Chain 18	UniProt (SwissProt) Entry Name of Target Chain 18	UniProt (SwissProt) Primary ID of Target Chain 18	UniProt (SwissProt) Secondary ID(s) of Target Chain 18	UniProt (SwissProt) Alternative ID(s) of Target Chain 18	UniProt (TrEMBL) Submitted Name of Target Chain 18	UniProt (TrEMBL) Entry Name of Target Chain 18	UniProt (TrEMBL) Primary ID of Target Chain 18	UniProt (TrEMBL) Secondary ID(s) of Target Chain 18	UniProt (TrEMBL) Alternative ID(s) of Target Chain 18	BindingDB Target Chain Sequence 19	PDB ID(s) of Target Chain 19	UniProt (SwissProt) Recommended Name of Target Chain 19	UniProt (SwissProt) Entry Name of Target Chain 19	UniProt (SwissProt) Primary ID of Target Chain 19	UniProt (SwissProt) Secondary ID(s) of Target Chain 19	UniProt (SwissProt) Alternative ID(s) of Target Chain 19	UniProt (TrEMBL) Submitted Name of Target Chain 19	UniProt (TrEMBL) Entry Name of Target Chain 19	UniProt (TrEMBL) Primary ID of Target Chain 19	UniProt (TrEMBL) Secondary ID(s) of Target Chain 19	UniProt (TrEMBL) Alternative ID(s) of Target Chain 19	BindingDB Target Chain Sequence 20	PDB ID(s) of Target Chain 20	UniProt (SwissProt) Recommended Name of Target Chain 20	UniProt (SwissProt) Entry Name of Target Chain 20	UniProt (SwissProt) Primary ID of Target Chain 20	UniProt (SwissProt) Secondary ID(s) of Target Chain 20	UniProt (SwissProt) Alternative ID(s) of Target Chain 20	UniProt (TrEMBL) Submitted Name of Target Chain 20	UniProt (TrEMBL) Entry Name of Target Chain 20	UniProt (TrEMBL) Primary ID of Target Chain 20	UniProt (TrEMBL) Secondary ID(s) of Target Chain 20	UniProt (TrEMBL) Alternative ID(s) of Target Chain 20	BindingDB Target Chain Sequence 21	PDB ID(s) of Target Chain 21	UniProt (SwissProt) Recommended Name of Target Chain 21	UniProt (SwissProt) Entry Name of Target Chain 21	UniProt (SwissProt) Primary ID of Target Chain 21	UniProt (SwissProt) Secondary ID(s) of Target Chain 21	UniProt (SwissProt) Alternative ID(s) of Target Chain 21	UniProt (TrEMBL) Submitted Name of Target Chain 21	UniProt (TrEMBL) Entry Name of Target Chain 21	UniProt (TrEMBL) Primary ID of Target Chain 21	UniProt (TrEMBL) Secondary ID(s) of Target Chain 21	UniProt (TrEMBL) Alternative ID(s) of Target Chain 21	BindingDB Target Chain Sequence 22	PDB ID(s) of Target Chain 22	UniProt (SwissProt) Recommended Name of Target Chain 22	UniProt (SwissProt) Entry Name of Target Chain 22	UniProt (SwissProt) Primary ID of Target Chain 22	UniProt (SwissProt) Secondary ID(s) of Target Chain 22	UniProt (SwissProt) Alternative ID(s) of Target Chain 22	UniProt (TrEMBL) Submitted Name of Target Chain 22	UniProt (TrEMBL) Entry Name of Target Chain 22	UniProt (TrEMBL) Primary ID of Target Chain 22	UniProt (TrEMBL) Secondary ID(s) of Target Chain 22	UniProt (TrEMBL) Alternative ID(s) of Target Chain 22	BindingDB Target Chain Sequence 23	PDB ID(s) of Target Chain 23	UniProt (SwissProt) Recommended Name of Target Chain 23	UniProt (SwissProt) Entry Name of Target Chain 23	UniProt (SwissProt) Primary ID of Target Chain 23	UniProt (SwissProt) Secondary ID(s) of Target Chain 23	UniProt (SwissProt) Alternative ID(s) of Target Chain 23	UniProt (TrEMBL) Submitted Name of Target Chain 23	UniProt (TrEMBL) Entry Name of Target Chain 23	UniProt (TrEMBL) Primary ID of Target Chain 23	UniProt (TrEMBL) Secondary ID(s) of Target Chain 23	UniProt (TrEMBL) Alternative ID(s) of Target Chain 23	BindingDB Target Chain Sequence 24	PDB ID(s) of Target Chain 24	UniProt (SwissProt) Recommended Name of Target Chain 24	UniProt (SwissProt) Entry Name of Target Chain 24	UniProt (SwissProt) Primary ID of Target Chain 24	UniProt (SwissProt) Secondary ID(s) of Target Chain 24	UniProt (SwissProt) Alternative ID(s) of Target Chain 24	UniProt (TrEMBL) Submitted Name of Target Chain 24	UniProt (TrEMBL) Entry Name of Target Chain 24	UniProt (TrEMBL) Primary ID of Target Chain 24	UniProt (TrEMBL) Secondary ID(s) of Target Chain 24	UniProt (TrEMBL) Alternative ID(s) of Target Chain 24	BindingDB Target Chain Sequence 25	PDB ID(s) of Target Chain 25	UniProt (SwissProt) Recommended Name of Target Chain 25	UniProt (SwissProt) Entry Name of Target Chain 25	UniProt (SwissProt) Primary ID of Target Chain 25	UniProt (SwissProt) Secondary ID(s) of Target Chain 25	UniProt (SwissProt) Alternative ID(s) of Target Chain 25	UniProt (TrEMBL) Submitted Name of Target Chain 25	UniProt (TrEMBL) Entry Name of Target Chain 25	UniProt (TrEMBL) Primary ID of Target Chain 25	UniProt (TrEMBL) Secondary ID(s) of Target Chain 25	UniProt (TrEMBL) Alternative ID(s) of Target Chain 25	BindingDB Target Chain Sequence 26	PDB ID(s) of Target Chain 26	UniProt (SwissProt) Recommended Name of Target Chain 26	UniProt (SwissProt) Entry Name of Target Chain 26	UniProt (SwissProt) Primary ID of Target Chain 26	UniProt (SwissProt) Secondary ID(s) of Target Chain 26	UniProt (SwissProt) Alternative ID(s) of Target Chain 26	UniProt (TrEMBL) Submitted Name of Target Chain 26	UniProt (TrEMBL) Entry Name of Target Chain 26	UniProt (TrEMBL) Primary ID of Target Chain 26	UniProt (TrEMBL) Secondary ID(s) of Target Chain 26	UniProt (TrEMBL) Alternative ID(s) of Target Chain 26	BindingDB Target Chain Sequence 27	PDB ID(s) of Target Chain 27	UniProt (SwissProt) Recommended Name of Target Chain 27	UniProt (SwissProt) Entry Name of Target Chain 27	UniProt (SwissProt) Primary ID of Target Chain 27	UniProt (SwissProt) Secondary ID(s) of Target Chain 27	UniProt (SwissProt) Alternative ID(s) of Target Chain 27	UniProt (TrEMBL) Submitted Name of Target Chain 27	UniProt (TrEMBL) Entry Name of Target Chain 27	UniProt (TrEMBL) Primary ID of Target Chain 27	UniProt (TrEMBL) Secondary ID(s) of Target Chain 27	UniProt (TrEMBL) Alternative ID(s) of Target Chain 27	BindingDB Target Chain Sequence 28	PDB ID(s) of Target Chain 28	UniProt (SwissProt) Recommended Name of Target Chain 28	UniProt (SwissProt) Entry Name of Target Chain 28	UniProt (SwissProt) Primary ID of Target Chain 28	UniProt (SwissProt) Secondary ID(s) of Target Chain 28	UniProt (SwissProt) Alternative ID(s) of Target Chain 28	UniProt (TrEMBL) Submitted Name of Target Chain 28	UniProt (TrEMBL) Entry Name of Target Chain 28	UniProt (TrEMBL) Primary ID of Target Chain 28	UniProt (TrEMBL) Secondary ID(s) of Target Chain 28	UniProt (TrEMBL) Alternative ID(s) of Target Chain 28	BindingDB Target Chain Sequence 29	PDB ID(s) of Target Chain 29	UniProt (SwissProt) Recommended Name of Target Chain 29	UniProt (SwissProt) Entry Name of Target Chain 29	UniProt (SwissProt) Primary ID of Target Chain 29	UniProt (SwissProt) Secondary ID(s) of Target Chain 29	UniProt (SwissProt) Alternative ID(s) of Target Chain 29	UniProt (TrEMBL) Submitted Name of Target Chain 29	UniProt (TrEMBL) Entry Name of Target Chain 29	UniProt (TrEMBL) Primary ID of Target Chain 29	UniProt (TrEMBL) Secondary ID(s) of Target Chain 29	UniProt (TrEMBL) Alternative ID(s) of Target Chain 29	BindingDB Target Chain Sequence 30	PDB ID(s) of Target Chain 30	UniProt (SwissProt) Recommended Name of Target Chain 30	UniProt (SwissProt) Entry Name of Target Chain 30	UniProt (SwissProt) Primary ID of Target Chain 30	UniProt (SwissProt) Secondary ID(s) of Target Chain 30	UniProt (SwissProt) Alternative ID(s) of Target Chain 30	UniProt (TrEMBL) Submitted Name of Target Chain 30	UniProt (TrEMBL) Entry Name of Target Chain 30	UniProt (TrEMBL) Primary ID of Target Chain 30	UniProt (TrEMBL) Secondary ID(s) of Target Chain 30	UniProt (TrEMBL) Alternative ID(s) of Target Chain 30	BindingDB Target Chain Sequence 31	PDB ID(s) of Target Chain 31	UniProt (SwissProt) Recommended Name of Target Chain 31	UniProt (SwissProt) Entry Name of Target Chain 31	UniProt (SwissProt) Primary ID of Target Chain 31	UniProt (SwissProt) Secondary ID(s) of Target Chain 31	UniProt (SwissProt) Alternative ID(s) of Target Chain 31	UniProt (TrEMBL) Submitted Name of Target Chain 31	UniProt (TrEMBL) Entry Name of Target Chain 31	UniProt (TrEMBL) Primary ID of Target Chain 31	UniProt (TrEMBL) Secondary ID(s) of Target Chain 31	UniProt (TrEMBL) Alternative ID(s) of Target Chain 31	BindingDB Target Chain Sequence 32	PDB ID(s) of Target Chain 32	UniProt (SwissProt) Recommended Name of Target Chain 32	UniProt (SwissProt) Entry Name of Target Chain 32	UniProt (SwissProt) Primary ID of Target Chain 32	UniProt (SwissProt) Secondary ID(s) of Target Chain 32	UniProt (SwissProt) Alternative ID(s) of Target Chain 32	UniProt (TrEMBL) Submitted Name of Target Chain 32	UniProt (TrEMBL) Entry Name of Target Chain 32	UniProt (TrEMBL) Primary ID of Target Chain 32	UniProt (TrEMBL) Secondary ID(s) of Target Chain 32	UniProt (TrEMBL) Alternative ID(s) of Target Chain 32	BindingDB Target Chain Sequence 33	PDB ID(s) of Target Chain 33	UniProt (SwissProt) Recommended Name of Target Chain 33	UniProt (SwissProt) Entry Name of Target Chain 33	UniProt (SwissProt) Primary ID of Target Chain 33	UniProt (SwissProt) Secondary ID(s) of Target Chain 33	UniProt (SwissProt) Alternative ID(s) of Target Chain 33	UniProt (TrEMBL) Submitted Name of Target Chain 33	UniProt (TrEMBL) Entry Name of Target Chain 33	UniProt (TrEMBL) Primary ID of Target Chain 33	UniProt (TrEMBL) Secondary ID(s) of Target Chain 33	UniProt (TrEMBL) Alternative ID(s) of Target Chain 33	BindingDB Target Chain Sequence 34	PDB ID(s) of Target Chain 34	UniProt (SwissProt) Recommended Name of Target Chain 34	UniProt (SwissProt) Entry Name of Target Chain 34	UniProt (SwissProt) Primary ID of Target Chain 34	UniProt (SwissProt) Secondary ID(s) of Target Chain 34	UniProt (SwissProt) Alternative ID(s) of Target Chain 34	UniProt (TrEMBL) Submitted Name of Target Chain 34	UniProt (TrEMBL) Entry Name of Target Chain 34	UniProt (TrEMBL) Primary ID of Target Chain 34	UniProt (TrEMBL) Secondary ID(s) of Target Chain 34	UniProt (TrEMBL) Alternative ID(s) of Target Chain 34	BindingDB Target Chain Sequence 35	PDB ID(s) of Target Chain 35	UniProt (SwissProt) Recommended Name of Target Chain 35	UniProt (SwissProt) Entry Name of Target Chain 35	UniProt (SwissProt) Primary ID of Target Chain 35	UniProt (SwissProt) Secondary ID(s) of Target Chain 35	UniProt (SwissProt) Alternative ID(s) of Target Chain 35	UniProt (TrEMBL) Submitted Name of Target Chain 35	UniProt (TrEMBL) Entry Name of Target Chain 35	UniProt (TrEMBL) Primary ID of Target Chain 35	UniProt (TrEMBL) Secondary ID(s) of Target Chain 35	UniProt (TrEMBL) Alternative ID(s) of Target Chain 35	BindingDB Target Chain Sequence 36	PDB ID(s) of Target Chain 36	UniProt (SwissProt) Recommended Name of Target Chain 36	UniProt (SwissProt) Entry Name of Target Chain 36	UniProt (SwissProt) Primary ID of Target Chain 36	UniProt (SwissProt) Secondary ID(s) of Target Chain 36	UniProt (SwissProt) Alternative ID(s) of Target Chain 36	UniProt (TrEMBL) Submitted Name of Target Chain 36	UniProt (TrEMBL) Entry Name of Target Chain 36	UniProt (TrEMBL) Primary ID of Target Chain 36	UniProt (TrEMBL) Secondary ID(s) of Target Chain 36	UniProt (TrEMBL) Alternative ID(s) of Target Chain 36	BindingDB Target Chain Sequence 37	PDB ID(s) of Target Chain 37	UniProt (SwissProt) Recommended Name of Target Chain 37	UniProt (SwissProt) Entry Name of Target Chain 37	UniProt (SwissProt) Primary ID of Target Chain 37	UniProt (SwissProt) Secondary ID(s) of Target Chain 37	UniProt (SwissProt) Alternative ID(s) of Target Chain 37	UniProt (TrEMBL) Submitted Name of Target Chain 37	UniProt (TrEMBL) Entry Name of Target Chain 37	UniProt (TrEMBL) Primary ID of Target Chain 37	UniProt (TrEMBL) Secondary ID(s) of Target Chain 37	UniProt (TrEMBL) Alternative ID(s) of Target Chain 37	BindingDB Target Chain Sequence 38	PDB ID(s) of Target Chain 38	UniProt (SwissProt) Recommended Name of Target Chain 38	UniProt (SwissProt) Entry Name of Target Chain 38	UniProt (SwissProt) Primary ID of Target Chain 38	UniProt (SwissProt) Secondary ID(s) of Target Chain 38	UniProt (SwissProt) Alternative ID(s) of Target Chain 38	UniProt (TrEMBL) Submitted Name of Target Chain 38	UniProt (TrEMBL) Entry Name of Target Chain 38	UniProt (TrEMBL) Primary ID of Target Chain 38	UniProt (TrEMBL) Secondary ID(s) of Target Chain 38	UniProt (TrEMBL) Alternative ID(s) of Target Chain 38	BindingDB Target Chain Sequence 39	PDB ID(s) of Target Chain 39	UniProt (SwissProt) Recommended Name of Target Chain 39	UniProt (SwissProt) Entry Name of Target Chain 39	UniProt (SwissProt) Primary ID of Target Chain 39	UniProt (SwissProt) Secondary ID(s) of Target Chain 39	UniProt (SwissProt) Alternative ID(s) of Target Chain 39	UniProt (TrEMBL) Submitted Name of Target Chain 39	UniProt (TrEMBL) Entry Name of Target Chain 39	UniProt (TrEMBL) Primary ID of Target Chain 39	UniProt (TrEMBL) Secondary ID(s) of Target Chain 39	UniProt (TrEMBL) Alternative ID(s) of Target Chain 39	BindingDB Target Chain Sequence 40	PDB ID(s) of Target Chain 40	UniProt (SwissProt) Recommended Name of Target Chain 40	UniProt (SwissProt) Entry Name of Target Chain 40	UniProt (SwissProt) Primary ID of Target Chain 40	UniProt (SwissProt) Secondary ID(s) of Target Chain 40	UniProt (SwissProt) Alternative ID(s) of Target Chain 40	UniProt (TrEMBL) Submitted Name of Target Chain 40	UniProt (TrEMBL) Entry Name of Target Chain 40	UniProt (TrEMBL) Primary ID of Target Chain 40	UniProt (TrEMBL) Secondary ID(s) of Target Chain 40	UniProt (TrEMBL) Alternative ID(s) of Target Chain 40	BindingDB Target Chain Sequence 41	PDB ID(s) of Target Chain 41	UniProt (SwissProt) Recommended Name of Target Chain 41	UniProt (SwissProt) Entry Name of Target Chain 41	UniProt (SwissProt) Primary ID of Target Chain 41	UniProt (SwissProt) Secondary ID(s) of Target Chain 41	UniProt (SwissProt) Alternative ID(s) of Target Chain 41	UniProt (TrEMBL) Submitted Name of Target Chain 41	UniProt (TrEMBL) Entry Name of Target Chain 41	UniProt (TrEMBL) Primary ID of Target Chain 41	UniProt (TrEMBL) Secondary ID(s) of Target Chain 41	UniProt (TrEMBL) Alternative ID(s) of Target Chain 41	BindingDB Target Chain Sequence 42	PDB ID(s) of Target Chain 42	UniProt (SwissProt) Recommended Name of Target Chain 42	UniProt (SwissProt) Entry Name of Target Chain 42	UniProt (SwissProt) Primary ID of Target Chain 42	UniProt (SwissProt) Secondary ID(s) of Target Chain 42	UniProt (SwissProt) Alternative ID(s) of Target Chain 42	UniProt (TrEMBL) Submitted Name of Target Chain 42	UniProt (TrEMBL) Entry Name of Target Chain 42	UniProt (TrEMBL) Primary ID of Target Chain 42	UniProt (TrEMBL) Secondary ID(s) of Target Chain 42	UniProt (TrEMBL) Alternative ID(s) of Target Chain 42	BindingDB Target Chain Sequence 43	PDB ID(s) of Target Chain 43	UniProt (SwissProt) Recommended Name of Target Chain 43	UniProt (SwissProt) Entry Name of Target Chain 43	UniProt (SwissProt) Primary ID of Target Chain 43	UniProt (SwissProt) Secondary ID(s) of Target Chain 43	UniProt (SwissProt) Alternative ID(s) of Target Chain 43	UniProt (TrEMBL) Submitted Name of Target Chain 43	UniProt (TrEMBL) Entry Name of Target Chain 43	UniProt (TrEMBL) Primary ID of Target Chain 43	UniProt (TrEMBL) Secondary ID(s) of Target Chain 43	UniProt (TrEMBL) Alternative ID(s) of Target Chain 43	BindingDB Target Chain Sequence 44	PDB ID(s) of Target Chain 44	UniProt (SwissProt) Recommended Name of Target Chain 44	UniProt (SwissProt) Entry Name of Target Chain 44	UniProt (SwissProt) Primary ID of Target Chain 44	UniProt (SwissProt) Secondary ID(s) of Target Chain 44	UniProt (SwissProt) Alternative ID(s) of Target Chain 44	UniProt (TrEMBL) Submitted Name of Target Chain 44	UniProt (TrEMBL) Entry Name of Target Chain 44	UniProt (TrEMBL) Primary ID of Target Chain 44	UniProt (TrEMBL) Secondary ID(s) of Target Chain 44	UniProt (TrEMBL) Alternative ID(s) of Target Chain 44	BindingDB Target Chain Sequence 45	PDB ID(s) of Target Chain 45	UniProt (SwissProt) Recommended Name of Target Chain 45	UniProt (SwissProt) Entry Name of Target Chain 45	UniProt (SwissProt) Primary ID of Target Chain 45	UniProt (SwissProt) Secondary ID(s) of Target Chain 45	UniProt (SwissProt) Alternative ID(s) of Target Chain 45	UniProt (TrEMBL) Submitted Name of Target Chain 45	UniProt (TrEMBL) Entry Name of Target Chain 45	UniProt (TrEMBL) Primary ID of Target Chain 45	UniProt (TrEMBL) Secondary ID(s) of Target Chain 45	UniProt (TrEMBL) Alternative ID(s) of Target Chain 45	BindingDB Target Chain Sequence 46	PDB ID(s) of Target Chain 46	UniProt (SwissProt) Recommended Name of Target Chain 46	UniProt (SwissProt) Entry Name of Target Chain 46	UniProt (SwissProt) Primary ID of Target Chain 46	UniProt (SwissProt) Secondary ID(s) of Target Chain 46	UniProt (SwissProt) Alternative ID(s) of Target Chain 46	UniProt (TrEMBL) Submitted Name of Target Chain 46	UniProt (TrEMBL) Entry Name of Target Chain 46	UniProt (TrEMBL) Primary ID of Target Chain 46	UniProt (TrEMBL) Secondary ID(s) of Target Chain 46	UniProt (TrEMBL) Alternative ID(s) of Target Chain 46	BindingDB Target Chain Sequence 47	PDB ID(s) of Target Chain 47	UniProt (SwissProt) Recommended Name of Target Chain 47	UniProt (SwissProt) Entry Name of Target Chain 47	UniProt (SwissProt) Primary ID of Target Chain 47	UniProt (SwissProt) Secondary ID(s) of Target Chain 47	UniProt (SwissProt) Alternative ID(s) of Target Chain 47	UniProt (TrEMBL) Submitted Name of Target Chain 47	UniProt (TrEMBL) Entry Name of Target Chain 47	UniProt (TrEMBL) Primary ID of Target Chain 47	UniProt (TrEMBL) Secondary ID(s) of Target Chain 47	UniProt (TrEMBL) Alternative ID(s) of Target Chain 47	BindingDB Target Chain Sequence 48	PDB ID(s) of Target Chain 48	UniProt (SwissProt) Recommended Name of Target Chain 48	UniProt (SwissProt) Entry Name of Target Chain 48	UniProt (SwissProt) Primary ID of Target Chain 48	UniProt (SwissProt) Secondary ID(s) of Target Chain 48	UniProt (SwissProt) Alternative ID(s) of Target Chain 48	UniProt (TrEMBL) Submitted Name of Target Chain 48	UniProt (TrEMBL) Entry Name of Target Chain 48	UniProt (TrEMBL) Primary ID of Target Chain 48	UniProt (TrEMBL) Secondary ID(s) of Target Chain 48	UniProt (TrEMBL) Alternative ID(s) of Target Chain 48	BindingDB Target Chain Sequence 49	PDB ID(s) of Target Chain 49	UniProt (SwissProt) Recommended Name of Target Chain 49	UniProt (SwissProt) Entry Name of Target Chain 49	UniProt (SwissProt) Primary ID of Target Chain 49	UniProt (SwissProt) Secondary ID(s) of Target Chain 49	UniProt (SwissProt) Alternative ID(s) of Target Chain 49	UniProt (TrEMBL) Submitted Name of Target Chain 49	UniProt (TrEMBL) Entry Name of Target Chain 49	UniProt (TrEMBL) Primary ID of Target Chain 49	UniProt (TrEMBL) Secondary ID(s) of Target Chain 49	UniProt (TrEMBL) Alternative ID(s) of Target Chain 49	BindingDB Target Chain Sequence 50	PDB ID(s) of Target Chain 50	UniProt (SwissProt) Recommended Name of Target Chain 50	UniProt (SwissProt) Entry Name of Target Chain 50	UniProt (SwissProt) Primary ID of Target Chain 50	UniProt (SwissProt) Secondary ID(s) of Target Chain 50	UniProt (SwissProt) Alternative ID(s) of Target Chain 50	UniProt (TrEMBL) Submitted Name of Target Chain 50	UniProt (TrEMBL) Entry Name of Target Chain 50	UniProt (TrEMBL) Primary ID of Target Chain 50	UniProt (TrEMBL) Secondary ID(s) of Target Chain 50	UniProt (TrEMBL) Alternative ID(s) of Target Chain 50
217310	O=C(CCc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3c[nH]nc3[N+](=O)[O-])c2)n1)Nc1ccccc1	InChI=1S/C28H23N7O4/c36-25(30-21-10-3-1-4-11-21)15-14-22-18-34(23-12-5-2-6-13-23)28(31-22)32-27(37)20-9-7-8-19(16-20)24-17-29-33-26(24)35(38)39/h1-13,16-18H,14-15H2,(H,29,33)(H,30,36)(H,31,32,37)	QFSSQJSJJXXHOW-UHFFFAOYSA-N	437166	US12534452, Example 1	Interleukin-1 receptor-associated kinase 4	Homo sapiens		>100							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437166	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437166&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			134493950	439658795							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217311	Nc1n[nH]cc1-c1cccc(C(=O)Nc2nc(CCC(=O)Nc3ccccc3)cn2-c2ccccc2)c1	InChI=1S/C28H25N7O2/c29-26-24(17-30-34-26)19-8-7-9-20(16-19)27(37)33-28-32-22(18-35(28)23-12-5-2-6-13-23)14-15-25(36)31-21-10-3-1-4-11-21/h1-13,16-18H,14-15H2,(H,31,36)(H3,29,30,34)(H,32,33,37)	HGDOERIWKFTJCP-UHFFFAOYSA-N	437167	US12534452, Example 2	Interleukin-1 receptor-associated kinase 4	Homo sapiens		>100							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437167	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437167&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			134493825	439658796							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217312	O=C(CCc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3c[nH]nc3C(F)(F)F)c2)n1)Nc1ccccc1	InChI=1S/C29H23F3N6O2/c30-29(31,32)26-24(17-33-37-26)19-8-7-9-20(16-19)27(40)36-28-35-22(18-38(28)23-12-5-2-6-13-23)14-15-25(39)34-21-10-3-1-4-11-21/h1-13,16-18H,14-15H2,(H,33,37)(H,34,39)(H,35,36,40)	HSTMOSMUFGAVEC-UHFFFAOYSA-N	437168	US12534452, Example 3	Interleukin-1 receptor-associated kinase 4	Homo sapiens		>100							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437168	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437168&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			134494083	439658797							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217313	O=C(CCc1cn(-c2ccccc2)c(NC(=O)c2cncc(-c3cn[nH]c3)c2)n1)Nc1ccccc1	InChI=1S/C27H23N7O2/c35-25(31-22-7-3-1-4-8-22)12-11-23-18-34(24-9-5-2-6-10-24)27(32-23)33-26(36)20-13-19(14-28-15-20)21-16-29-30-17-21/h1-10,13-18H,11-12H2,(H,29,30)(H,31,35)(H,32,33,36)	SWYDDFLPEVTNPB-UHFFFAOYSA-N	437248	US12534452, Example 4	Interleukin-1 receptor-associated kinase 4	Homo sapiens		>100							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437248	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437248&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			134490189	439658877							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217314	O=C(CCc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3cnoc3)c2)n1)Nc1ccccc1	InChI=1S/C28H23N5O3/c34-26(30-23-10-3-1-4-11-23)15-14-24-18-33(25-12-5-2-6-13-25)28(31-24)32-27(35)21-9-7-8-20(16-21)22-17-29-36-19-22/h1-13,16-19H,14-15H2,(H,30,34)(H,31,32,35)	MWYPLWOAQXONKT-UHFFFAOYSA-N	437249	US12534452, Example 5	Interleukin-1 receptor-associated kinase 4	Homo sapiens		>100							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437249	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437249&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			134490190	439658878							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217315	O=C(CCc1cn(-c2ccccc2)c(NC(=O)c2cccc(C3=CNNC3)c2)n1)Nc1ccccc1	InChI=1S/C28H26N6O2/c35-26(31-23-10-3-1-4-11-23)15-14-24-19-34(25-12-5-2-6-13-25)28(32-24)33-27(36)21-9-7-8-20(16-21)22-17-29-30-18-22/h1-13,16-17,19,29-30H,14-15,18H2,(H,31,35)(H,32,33,36)	XZEIHMIHTBFKBZ-UHFFFAOYSA-N	437250	US12534452, Example 6	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437250	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437250&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			134493666	439658879							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217316	O=C(O)CCc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3cn[nH]c3)c2)n1	InChI=1S/C22H19N5O3/c28-20(29)10-9-18-14-27(19-7-2-1-3-8-19)22(25-18)26-21(30)16-6-4-5-15(11-16)17-12-23-24-13-17/h1-8,11-14H,9-10H2,(H,23,24)(H,28,29)(H,25,26,30)	JXZZJVCKKQHOPO-UHFFFAOYSA-N	437251	US12534452, Example 7	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437251	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437251&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			134493671	439658880							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217317	O=C(CCc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3cn[nH]c3)c2)n1)NN1CCCCC1	InChI=1S/C27H29N7O2/c35-25(32-33-14-5-2-6-15-33)13-12-23-19-34(24-10-3-1-4-11-24)27(30-23)31-26(36)21-9-7-8-20(16-21)22-17-28-29-18-22/h1,3-4,7-11,16-19H,2,5-6,12-15H2,(H,28,29)(H,32,35)(H,30,31,36)	DMKWRIJCSZNZMP-UHFFFAOYSA-N	437252	US12534452, Example 8	Interleukin-1 receptor-associated kinase 4	Homo sapiens		 75							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437252	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437252&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			134493973	439658881							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217318	CN1CCN(NC(=O)CCc2cn(-c3ccccc3)c(NC(=O)c3cccc(-c4cn[nH]c4)c3)n2)CC1	InChI=1S/C27H30N8O2/c1-33-12-14-34(15-13-33)32-25(36)11-10-23-19-35(24-8-3-2-4-9-24)27(30-23)31-26(37)21-7-5-6-20(16-21)22-17-28-29-18-22/h2-9,16-19H,10-15H2,1H3,(H,28,29)(H,32,36)(H,30,31,37)	KKDFIZRHPIVNAR-UHFFFAOYSA-N	437253	US12534452, Example 9	Interleukin-1 receptor-associated kinase 4	Homo sapiens		>100							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437253	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437253&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			134490195	439658882							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217319	O=C(CCc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3cn[nH]c3)c2)n1)Nc1ccc(F)cc1	InChI=1S/C28H23FN6O2/c29-22-9-11-23(12-10-22)32-26(36)14-13-24-18-35(25-7-2-1-3-8-25)28(33-24)34-27(37)20-6-4-5-19(15-20)21-16-30-31-17-21/h1-12,15-18H,13-14H2,(H,30,31)(H,32,36)(H,33,34,37)	YIRDCRDEDBLQGN-UHFFFAOYSA-N	437254	US12534452, Example 10	Interleukin-1 receptor-associated kinase 4	Homo sapiens		 75							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437254	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437254&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			134490194	439658883							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217320	O=C(Nc1nc(CCC(=O)N2CCOCC2)cn1-c1ccccc1)c1cccc(-c2cn[nH]c2)c1	InChI=1S/C26H26N6O3/c33-24(31-11-13-35-14-12-31)10-9-22-18-32(23-7-2-1-3-8-23)26(29-22)30-25(34)20-6-4-5-19(15-20)21-16-27-28-17-21/h1-8,15-18H,9-14H2,(H,27,28)(H,29,30,34)	QOFYIMIXNONVER-UHFFFAOYSA-N	437255	US12534452, Example 11	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437255	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437255&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			155295430	439658884							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217321	O=C(Nc1nc(CCC(=O)N2CCCCC2)cn1-c1ccccc1)c1cccc(-c2cn[nH]c2)c1	InChI=1S/C27H28N6O2/c34-25(32-14-5-2-6-15-32)13-12-23-19-33(24-10-3-1-4-11-24)27(30-23)31-26(35)21-9-7-8-20(16-21)22-17-28-29-18-22/h1,3-4,7-11,16-19H,2,5-6,12-15H2,(H,28,29)(H,30,31,35)	RDTGOJDHNMIDGV-UHFFFAOYSA-N	437256	US12534452, Example 12	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437256	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437256&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			134494002	439658885							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217322	COC[C@@H]1CCCN1NC(=O)CCc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3cn[nH]c3)c2)n1	InChI=1S/C28H31N7O3/c1-38-19-25-11-6-14-35(25)33-26(36)13-12-23-18-34(24-9-3-2-4-10-24)28(31-23)32-27(37)21-8-5-7-20(15-21)22-16-29-30-17-22/h2-5,7-10,15-18,25H,6,11-14,19H2,1H3,(H,29,30)(H,33,36)(H,31,32,37)	GVBBCRLYACNSDE-UHFFFAOYSA-N	437257	US12534452, Example 13	Interleukin-1 receptor-associated kinase 4	Homo sapiens		 75							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437257	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437257&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			155295431	439658886							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217323	O=C(Nc1nc(CCC(=O)N2CCN(Cc3ccc(OC(F)(F)F)cc3)CC2)cn1-c1ccccc1)c1cccc(-c2cn[nH]c2)c1	InChI=1S/C34H32F3N7O3/c35-34(36,37)47-30-12-9-24(10-13-30)22-42-15-17-43(18-16-42)31(45)14-11-28-23-44(29-7-2-1-3-8-29)33(40-28)41-32(46)26-6-4-5-25(19-26)27-20-38-39-21-27/h1-10,12-13,19-21,23H,11,14-18,22H2,(H,38,39)(H,40,41,46)	PYWQHDQRBKKZEI-UHFFFAOYSA-N	437258	US12534452, Example 14	Interleukin-1 receptor-associated kinase 4	Homo sapiens		>100							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437258	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437258&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			155295432	439658887							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217324	O=C(CCc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3cn[nH]c3)c2)n1)Nc1ccccn1	InChI=1S/C27H23N7O2/c35-25(32-24-11-4-5-14-28-24)13-12-22-18-34(23-9-2-1-3-10-23)27(31-22)33-26(36)20-8-6-7-19(15-20)21-16-29-30-17-21/h1-11,14-18H,12-13H2,(H,29,30)(H,28,32,35)(H,31,33,36)	XPHRUKBZVKBXBK-UHFFFAOYSA-N	437259	US12534452, Example 15	Interleukin-1 receptor-associated kinase 4	Homo sapiens		>100							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437259	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437259&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			134493961	439658888							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217325	O=C(CCc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3cn[nH]c3)c2)n1)Nc1ccc(F)cc1F	InChI=1S/C28H22F2N6O2/c29-21-9-11-25(24(30)14-21)34-26(37)12-10-22-17-36(23-7-2-1-3-8-23)28(33-22)35-27(38)19-6-4-5-18(13-19)20-15-31-32-16-20/h1-9,11,13-17H,10,12H2,(H,31,32)(H,34,37)(H,33,35,38)	WGTVCLHEPYIERU-UHFFFAOYSA-N	437260	US12534452, Example 16	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437260	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437260&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			134493894	439658889							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217326	COC[C@H]1CCCN1NC(=O)CCc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3cn[nH]c3)c2)n1	InChI=1S/C28H31N7O3/c1-38-19-25-11-6-14-35(25)33-26(36)13-12-23-18-34(24-9-3-2-4-10-24)28(31-23)32-27(37)21-8-5-7-20(15-21)22-16-29-30-17-22/h2-5,7-10,15-18,25H,6,11-14,19H2,1H3,(H,29,30)(H,33,36)(H,31,32,37)	GVBBCRLYACNSDE-UHFFFAOYSA-N	437261	US12534452, Example 17	Interleukin-1 receptor-associated kinase 4	Homo sapiens		>100							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437261	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437261&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			134493963	439658890							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217327	COC(=O)CCc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3cn[nH]c3)c2)n1	InChI=1S/C23H21N5O3/c1-31-21(29)11-10-19-15-28(20-8-3-2-4-9-20)23(26-19)27-22(30)17-7-5-6-16(12-17)18-13-24-25-14-18/h2-9,12-15H,10-11H2,1H3,(H,24,25)(H,26,27,30)	WHEXRMCBUDMICL-UHFFFAOYSA-N	437262	US12534452, Example 18	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437262	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437262&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			155295433	439658891							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217328	COC[C@@H]1CCCN1C(=O)CCc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3cn[nH]c3)c2)n1	InChI=1S/C28H30N6O3/c1-37-19-25-11-6-14-33(25)26(35)13-12-23-18-34(24-9-3-2-4-10-24)28(31-23)32-27(36)21-8-5-7-20(15-21)22-16-29-30-17-22/h2-5,7-10,15-18,25H,6,11-14,19H2,1H3,(H,29,30)(H,31,32,36)	UYTLNOQLYUZUHA-UHFFFAOYSA-N	437263	US12534452, Example 19	Interleukin-1 receptor-associated kinase 4	Homo sapiens		 75							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437263	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437263&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			155295434	439658892							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217329	COC[C@H]1CCCN1C(=O)CCc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3cn[nH]c3)c2)n1	InChI=1S/C28H30N6O3/c1-37-19-25-11-6-14-33(25)26(35)13-12-23-18-34(24-9-3-2-4-10-24)28(31-23)32-27(36)21-8-5-7-20(15-21)22-16-29-30-17-22/h2-5,7-10,15-18,25H,6,11-14,19H2,1H3,(H,29,30)(H,31,32,36)	UYTLNOQLYUZUHA-UHFFFAOYSA-N	437264	US12534452, Example 20	Interleukin-1 receptor-associated kinase 4	Homo sapiens		>100							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437264	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437264&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			134493877	439658893							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217330	O=C(CCc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3cn[nH]c3)c2)n1)Nn1cnnc1	InChI=1S/C24H21N9O2/c34-22(31-32-15-27-28-16-32)10-9-20-14-33(21-7-2-1-3-8-21)24(29-20)30-23(35)18-6-4-5-17(11-18)19-12-25-26-13-19/h1-8,11-16H,9-10H2,(H,25,26)(H,31,34)(H,29,30,35)	PKOROKBRRSOQQN-UHFFFAOYSA-N	437265	US12534452, Example 21	Interleukin-1 receptor-associated kinase 4	Homo sapiens		 75							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437265	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437265&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			134493960	439658894							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217331	O=C(CCc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3cn[nH]c3)c2)n1)Nc1cnccn1	InChI=1S/C26H22N8O2/c35-24(32-23-16-27-11-12-28-23)10-9-21-17-34(22-7-2-1-3-8-22)26(31-21)33-25(36)19-6-4-5-18(13-19)20-14-29-30-15-20/h1-8,11-17H,9-10H2,(H,29,30)(H,28,32,35)(H,31,33,36)	GSCYHGZMGCYGRI-UHFFFAOYSA-N	437266	US12534452, Example 22	Interleukin-1 receptor-associated kinase 4	Homo sapiens		>100							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=437266	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=437266&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			134493865	439658895							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217332	C[C@@H]1CCCN1C(=O)CCc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3cn[nH]c3)c2)n1	InChI=1S/C27H28N6O2/c1-19-7-6-14-32(19)25(34)13-12-23-18-33(24-10-3-2-4-11-24)27(30-23)31-26(35)21-9-5-8-20(15-21)22-16-28-29-17-22/h2-5,8-11,15-19H,6-7,12-14H2,1H3,(H,28,29)(H,30,31,35)	VBQWHRNCUKTZPV-UHFFFAOYSA-N	446172	US12534452, Example 23	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=446172	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=446172&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search											1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217333	C[C@H]1CCCN1C(=O)CCc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3cn[nH]c3)c2)n1	InChI=1S/C27H28N6O2/c1-19-7-6-14-32(19)25(34)13-12-23-18-33(24-10-3-2-4-11-24)27(30-23)31-26(35)21-9-5-8-20(15-21)22-16-28-29-17-22/h2-5,8-11,15-19H,6-7,12-14H2,1H3,(H,28,29)(H,30,31,35)	VBQWHRNCUKTZPV-UHFFFAOYSA-N	446199	US12534452, Example 24	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=446199	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=446199&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search											1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217334	O=C(Nc1nc(CCC(=O)N2CC[C@@H](C(=O)O)C2)cn1-c1ccccc1)c1cccc(-c2cn[nH]c2)c1	InChI=1S/C27H26N6O4/c34-24(32-12-11-20(16-32)26(36)37)10-9-22-17-33(23-7-2-1-3-8-23)27(30-22)31-25(35)19-6-4-5-18(13-19)21-14-28-29-15-21/h1-8,13-15,17,20H,9-12,16H2,(H,28,29)(H,36,37)(H,30,31,35)	JICZPXHCHLKVNK-UHFFFAOYSA-N	446200	US12534452, Example 25	Interleukin-1 receptor-associated kinase 4	Homo sapiens		 75							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=446200	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=446200&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search											1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217335	O=C(Nc1nc(CCC(=O)N2CC[C@H](C(=O)O)C2)cn1-c1ccccc1)c1cccc(-c2cn[nH]c2)c1	InChI=1S/C27H26N6O4/c34-24(32-12-11-20(16-32)26(36)37)10-9-22-17-33(23-7-2-1-3-8-23)27(30-22)31-25(35)19-6-4-5-18(13-19)21-14-28-29-15-21/h1-8,13-15,17,20H,9-12,16H2,(H,28,29)(H,36,37)(H,30,31,35)	JICZPXHCHLKVNK-UHFFFAOYSA-N	474946	US12534452, Example 26	Interleukin-1 receptor-associated kinase 4	Homo sapiens		>100							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=474946	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=474946&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search											1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217336	O=C(CCc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3cn[nH]c3)c2)n1)NN1CCCC1	InChI=1S/C26H27N7O2/c34-24(31-32-13-4-5-14-32)12-11-22-18-33(23-9-2-1-3-10-23)26(29-22)30-25(35)20-8-6-7-19(15-20)21-16-27-28-17-21/h1-3,6-10,15-18H,4-5,11-14H2,(H,27,28)(H,31,34)(H,29,30,35)	WNMVNFFNZGZFAX-UHFFFAOYSA-N	476218	US12534452, Example 27	Interleukin-1 receptor-associated kinase 4	Homo sapiens		>100							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=476218	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=476218&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			155439684	442076283							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217337	O=C(Nc1nc(CCC(=O)N2CCCC2)cn1-c1ccccc1)c1cccc(-c2cn[nH]c2)c1	InChI=1S/C26H26N6O2/c33-24(31-13-4-5-14-31)12-11-22-18-32(23-9-2-1-3-10-23)26(29-22)30-25(34)20-8-6-7-19(15-20)21-16-27-28-17-21/h1-3,6-10,15-18H,4-5,11-14H2,(H,27,28)(H,29,30,34)	GTFLBRHVXCSWGA-UHFFFAOYSA-N	476221	US12534452, Example 28	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=476221	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=476221&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			155439724	442076286							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217338	C[C@@H]1CC[C@@H](C)N1C(=O)CCc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3cn[nH]c3)c2)n1	InChI=1S/C28H30N6O2/c1-19-11-12-20(2)34(19)26(35)14-13-24-18-33(25-9-4-3-5-10-25)28(31-24)32-27(36)22-8-6-7-21(15-22)23-16-29-30-17-23/h3-10,15-20H,11-14H2,1-2H3,(H,29,30)(H,31,32,36)	SKYYNGDVWYQCTI-UHFFFAOYSA-N	476229	US12534452, Example 29	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=476229	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=476229&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			156023132	442076294					C03768		1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217339	C[C@@H]1CCCCN1C(=O)CCc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3cn[nH]c3)c2)n1	InChI=1S/C28H30N6O2/c1-20-8-5-6-15-33(20)26(35)14-13-24-19-34(25-11-3-2-4-12-25)28(31-24)32-27(36)22-10-7-9-21(16-22)23-17-29-30-18-23/h2-4,7,9-12,16-20H,5-6,8,13-15H2,1H3,(H,29,30)(H,31,32,36)	CMTQCASAVLBTOB-UHFFFAOYSA-N	479144	US12534452, Example 30	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479144	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479144&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130341866	442138713							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217340	C[C@H]1CCCCN1C(=O)CCc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3cn[nH]c3)c2)n1	InChI=1S/C28H30N6O2/c1-20-8-5-6-15-33(20)26(35)14-13-24-19-34(25-11-3-2-4-12-25)28(31-24)32-27(36)22-10-7-9-21(16-22)23-17-29-30-18-23/h2-4,7,9-12,16-20H,5-6,8,13-15H2,1H3,(H,29,30)(H,31,32,36)	CMTQCASAVLBTOB-UHFFFAOYSA-N	479145	US12534452, Example 31	Interleukin-1 receptor-associated kinase 4	Homo sapiens		 75							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479145	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479145&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130342103	442138714							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217341	C[C@@H]1CCC[C@H](C)N1C(=O)CCc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3cn[nH]c3)c2)n1	InChI=1S/C29H32N6O2/c1-20-8-6-9-21(2)35(20)27(36)15-14-25-19-34(26-12-4-3-5-13-26)29(32-25)33-28(37)23-11-7-10-22(16-23)24-17-30-31-18-24/h3-5,7,10-13,16-21H,6,8-9,14-15H2,1-2H3,(H,30,31)(H,32,33,37)	GLNLGEUMJCRVRK-UHFFFAOYSA-N	479146	US12534452, Example 32	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479146	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479146&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130341864	442138715							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217342	CNC(=O)CCc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3cn[nH]c3)c2)n1	InChI=1S/C23H22N6O2/c1-24-21(30)11-10-19-15-29(20-8-3-2-4-9-20)23(27-19)28-22(31)17-7-5-6-16(12-17)18-13-25-26-14-18/h2-9,12-15H,10-11H2,1H3,(H,24,30)(H,25,26)(H,27,28,31)	DJHQNHKIKDBYQN-UHFFFAOYSA-N	479147	US12534452, Example 33	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479147	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479147&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130341878	442138716							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217343	CC1(C)CCCN(C(=O)CCc2cn(-c3ccccc3)c(NC(=O)c3cccc(-c4cn[nH]c4)c3)n2)C1	InChI=1S/C29H32N6O2/c1-29(2)14-7-15-34(20-29)26(36)13-12-24-19-35(25-10-4-3-5-11-25)28(32-24)33-27(37)22-9-6-8-21(16-22)23-17-30-31-18-23/h3-6,8-11,16-19H,7,12-15,20H2,1-2H3,(H,30,31)(H,32,33,37)	RWJUHVIMBLOHSV-UHFFFAOYSA-N	479148	US12534452, Example 34	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479148	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479148&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130342233	442138717							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217344	CC1(C)CCN(C(=O)CCc2cn(-c3ccccc3)c(NC(=O)c3cccc(-c4cn[nH]c4)c3)n2)CC1	InChI=1S/C29H32N6O2/c1-29(2)13-15-34(16-14-29)26(36)12-11-24-20-35(25-9-4-3-5-10-25)28(32-24)33-27(37)22-8-6-7-21(17-22)23-18-30-31-19-23/h3-10,17-20H,11-16H2,1-2H3,(H,30,31)(H,32,33,37)	VXJJUKGSQXPMLK-UHFFFAOYSA-N	479149	US12534452, Example 35	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479149	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479149&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130341778	442138718							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217345	O=C(Nc1nc(CCC(=O)N2CCCC(C(=O)O)C2)cn1-c1ccccc1)c1cccc(-c2cn[nH]c2)c1	InChI=1S/C28H28N6O4/c35-25(33-13-5-8-21(17-33)27(37)38)12-11-23-18-34(24-9-2-1-3-10-24)28(31-23)32-26(36)20-7-4-6-19(14-20)22-15-29-30-16-22/h1-4,6-7,9-10,14-16,18,21H,5,8,11-13,17H2,(H,29,30)(H,37,38)(H,31,32,36)	PBXPVMJARAMVOF-UHFFFAOYSA-N	479150	US12534452, Example 36	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479150	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479150&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130341946	442138719							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217346	O=C(Nc1nc(CCC(=O)N2CCCC(C(=O)O)C2)cn1-c1ccccc1)c1cccc(-c2cn[nH]c2)c1	InChI=1S/C28H28N6O4/c35-25(33-13-5-8-21(17-33)27(37)38)12-11-23-18-34(24-9-2-1-3-10-24)28(31-23)32-26(36)20-7-4-6-19(14-20)22-15-29-30-16-22/h1-4,6-7,9-10,14-16,18,21H,5,8,11-13,17H2,(H,29,30)(H,37,38)(H,31,32,36)	PBXPVMJARAMVOF-UHFFFAOYSA-N	479151	US12534452, Example 37	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479151	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479151&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130342243	442138720							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217347	O=C(Nc1nc(CCC(=O)N2CCCC[C@H]2C(F)(F)F)cn1-c1ccccc1)c1cccc(-c2cn[nH]c2)c1	InChI=1S/C28H27F3N6O2/c29-28(30,31)24-11-4-5-14-36(24)25(38)13-12-22-18-37(23-9-2-1-3-10-23)27(34-22)35-26(39)20-8-6-7-19(15-20)21-16-32-33-17-21/h1-3,6-10,15-18,24H,4-5,11-14H2,(H,32,33)(H,34,35,39)	LZUCSXUOPYDXPX-UHFFFAOYSA-N	479152	US12534452, Example 38	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479152	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479152&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			138624141	442138721							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217348	O=C(Nc1nc(CCC(=O)N2CCCC[C@@H]2C(F)(F)F)cn1-c1ccccc1)c1cccc(-c2cn[nH]c2)c1	InChI=1S/C28H27F3N6O2/c29-28(30,31)24-11-4-5-14-36(24)25(38)13-12-22-18-37(23-9-2-1-3-10-23)27(34-22)35-26(39)20-8-6-7-19(15-20)21-16-32-33-17-21/h1-3,6-10,15-18,24H,4-5,11-14H2,(H,32,33)(H,34,35,39)	LZUCSXUOPYDXPX-UHFFFAOYSA-N	479153	US12534452, Example 39	Interleukin-1 receptor-associated kinase 4	Homo sapiens		 75							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479153	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479153&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130342094	442138722							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217349	N[C@@H]1CCCN(C(=O)CCc2cn(-c3ccccc3)c(NC(=O)c3cccc(-c4cn[nH]c4)c3)n2)C1	InChI=1S/C27H29N7O2/c28-22-8-5-13-33(17-22)25(35)12-11-23-18-34(24-9-2-1-3-10-24)27(31-23)32-26(36)20-7-4-6-19(14-20)21-15-29-30-16-21/h1-4,6-7,9-10,14-16,18,22H,5,8,11-13,17,28H2,(H,29,30)(H,31,32,36)	FPTPQCPPPFWWRC-UHFFFAOYSA-N	479154	US12534452, Example 40	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479154	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479154&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130342274	442138723							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217350	CNC(=O)Cc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3cn[nH]c3)c2)n1	InChI=1S/C22H20N6O2/c1-23-20(29)11-18-14-28(19-8-3-2-4-9-19)22(26-18)27-21(30)16-7-5-6-15(10-16)17-12-24-25-13-17/h2-10,12-14H,11H2,1H3,(H,23,29)(H,24,25)(H,26,27,30)	BQQJVIDIHNZLKV-UHFFFAOYSA-N	479155	US12534452, Example 41	Interleukin-1 receptor-associated kinase 4	Homo sapiens		>100							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479155	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479155&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130342272	442138724							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217351	COC(=O)Cc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3cn[nH]c3)c2)n1	InChI=1S/C22H19N5O3/c1-30-20(28)11-18-14-27(19-8-3-2-4-9-19)22(25-18)26-21(29)16-7-5-6-15(10-16)17-12-23-24-13-17/h2-10,12-14H,11H2,1H3,(H,23,24)(H,25,26,29)	CHNKZLCCQCCCEY-UHFFFAOYSA-N	479156	US12534452, Example 42	Interleukin-1 receptor-associated kinase 4	Homo sapiens		 75							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479156	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479156&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			138624274	442138725							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217352	O=C(O)Cc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3cn[nH]c3)c2)n1	InChI=1S/C21H17N5O3/c27-19(28)10-17-13-26(18-7-2-1-3-8-18)21(24-17)25-20(29)15-6-4-5-14(9-15)16-11-22-23-12-16/h1-9,11-13H,10H2,(H,22,23)(H,27,28)(H,24,25,29)	BGVYHNLPHZJWKN-UHFFFAOYSA-N	479157	US12534452, Example 43	Interleukin-1 receptor-associated kinase 4	Homo sapiens		>100							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479157	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479157&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130341876	442138726							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217353	COC[C@@H]1CCCN1NC(=O)Cc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3cn[nH]c3)c2)n1	InChI=1S/C27H29N7O3/c1-37-18-24-11-6-12-34(24)32-25(35)14-22-17-33(23-9-3-2-4-10-23)27(30-22)31-26(36)20-8-5-7-19(13-20)21-15-28-29-16-21/h2-5,7-10,13,15-17,24H,6,11-12,14,18H2,1H3,(H,28,29)(H,32,35)(H,30,31,36)	BHETZOMKBFSMNC-UHFFFAOYSA-N	479158	US12534452, Example 44	Interleukin-1 receptor-associated kinase 4	Homo sapiens		>100							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479158	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479158&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			138624412	442138727							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217354	COC[C@H]1CCCN1NC(=O)Cc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3cn[nH]c3)c2)n1	InChI=1S/C27H29N7O3/c1-37-18-24-11-6-12-34(24)32-25(35)14-22-17-33(23-9-3-2-4-10-23)27(30-22)31-26(36)20-8-5-7-19(13-20)21-15-28-29-16-21/h2-5,7-10,13,15-17,24H,6,11-12,14,18H2,1H3,(H,28,29)(H,32,35)(H,30,31,36)	BHETZOMKBFSMNC-UHFFFAOYSA-N	479159	US12534452, Example 45	Interleukin-1 receptor-associated kinase 4	Homo sapiens		 75							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479159	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479159&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			138624081	442138728							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217355	COC[C@@H]1CCCN1C(=O)Cc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3cn[nH]c3)c2)n1	InChI=1S/C27H28N6O3/c1-36-18-24-11-6-12-32(24)25(34)14-22-17-33(23-9-3-2-4-10-23)27(30-22)31-26(35)20-8-5-7-19(13-20)21-15-28-29-16-21/h2-5,7-10,13,15-17,24H,6,11-12,14,18H2,1H3,(H,28,29)(H,30,31,35)	SZBNYQPEHUDXDF-UHFFFAOYSA-N	479160	US12534452, Example 46	Interleukin-1 receptor-associated kinase 4	Homo sapiens		 75							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479160	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479160&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			138624097	442138729							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217356	COC[C@H]1CCCN1C(=O)Cc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3cn[nH]c3)c2)n1	InChI=1S/C27H28N6O3/c1-36-18-24-11-6-12-32(24)25(34)14-22-17-33(23-9-3-2-4-10-23)27(30-22)31-26(35)20-8-5-7-19(13-20)21-15-28-29-16-21/h2-5,7-10,13,15-17,24H,6,11-12,14,18H2,1H3,(H,28,29)(H,30,31,35)	SZBNYQPEHUDXDF-UHFFFAOYSA-N	479161	US12534452, Example 47	Interleukin-1 receptor-associated kinase 4	Homo sapiens		>100							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479161	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479161&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130342073	442138730							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217357	CNC(=O)Cc1cn(-c2ccccc2)c(NC(=O)c2ccc(-c3cn[nH]c3)cc2)n1	InChI=1S/C22H20N6O2/c1-23-20(29)11-18-14-28(19-5-3-2-4-6-19)22(26-18)27-21(30)16-9-7-15(8-10-16)17-12-24-25-13-17/h2-10,12-14H,11H2,1H3,(H,23,29)(H,24,25)(H,26,27,30)	ZIRMERJPTBOSBY-UHFFFAOYSA-N	479162	US12534452, Example 48	Interleukin-1 receptor-associated kinase 4	Homo sapiens		>100							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479162	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479162&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130342075	442138731							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217358	CNC(=O)Cc1cn(-c2ccccc2)c(NC(=O)c2ccc3[nH]ncc3c2)n1	InChI=1S/C20H18N6O2/c1-21-18(27)10-15-12-26(16-5-3-2-4-6-16)20(23-15)24-19(28)13-7-8-17-14(9-13)11-22-25-17/h2-9,11-12H,10H2,1H3,(H,21,27)(H,22,25)(H,23,24,28)	KCZOJPFAZAYVMW-UHFFFAOYSA-N	479163	US12534452, Example 49	Interleukin-1 receptor-associated kinase 4	Homo sapiens		>100							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479163	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479163&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130342063	442138732							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217359	CNC(=O)Cc1cn(-c2ccccc2)c(NC(=O)c2ccccc2)n1	InChI=1S/C19H18N4O2/c1-20-17(24)12-15-13-23(16-10-6-3-7-11-16)19(21-15)22-18(25)14-8-4-2-5-9-14/h2-11,13H,12H2,1H3,(H,20,24)(H,21,22,25)	DQTAHPLUTPAUBB-UHFFFAOYSA-N	479164	US12534452, Example 50	Interleukin-1 receptor-associated kinase 4	Homo sapiens		>100							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479164	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479164&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130342059	442138733							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217360	CNC(=O)Cc1cn(-c2ccccc2)c(NC(=O)c2cccnc2)n1	InChI=1S/C18H17N5O2/c1-19-16(24)10-14-12-23(15-7-3-2-4-8-15)18(21-14)22-17(25)13-6-5-9-20-11-13/h2-9,11-12H,10H2,1H3,(H,19,24)(H,21,22,25)	NFSOFMAUKQZIJX-UHFFFAOYSA-N	479165	US12534452, Example 51	Interleukin-1 receptor-associated kinase 4	Homo sapiens		>100							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479165	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479165&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130341796	442138734							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217361	O=C(CCCc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3cn[nH]c3)c2)n1)Nc1ccccc1	InChI=1S/C29H26N6O2/c36-27(32-24-11-3-1-4-12-24)16-8-13-25-20-35(26-14-5-2-6-15-26)29(33-25)34-28(37)22-10-7-9-21(17-22)23-18-30-31-19-23/h1-7,9-12,14-15,17-20H,8,13,16H2,(H,30,31)(H,32,36)(H,33,34,37)	HKVHVDOJSQVUNJ-UHFFFAOYSA-N	479166	US12534452, Example 52	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479166	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479166&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130341521	442138735							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217362	COC[C@@H]1CCCN1NC(=O)CCCc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3cn[nH]c3)c2)n1	InChI=1S/C29H33N7O3/c1-39-20-26-13-7-15-36(26)34-27(37)14-6-10-24-19-35(25-11-3-2-4-12-25)29(32-24)33-28(38)22-9-5-8-21(16-22)23-17-30-31-18-23/h2-5,8-9,11-12,16-19,26H,6-7,10,13-15,20H2,1H3,(H,30,31)(H,34,37)(H,32,33,38)	MJAPZMRLTAYJDC-UHFFFAOYSA-N	479167	US12534452, Example 53	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479167	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479167&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130341522	442138736							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217363	COC[C@H]1CCCN1NC(=O)CCCc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3cn[nH]c3)c2)n1	InChI=1S/C29H33N7O3/c1-39-20-26-13-7-15-36(26)34-27(37)14-6-10-24-19-35(25-11-3-2-4-12-25)29(32-24)33-28(38)22-9-5-8-21(16-22)23-17-30-31-18-23/h2-5,8-9,11-12,16-19,26H,6-7,10,13-15,20H2,1H3,(H,30,31)(H,34,37)(H,32,33,38)	MJAPZMRLTAYJDC-UHFFFAOYSA-N	479168	US12534452, Example 54	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479168	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479168&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			141660141	442138737							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217364	COC[C@@H]1CCCN1C(=O)CCCc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3cn[nH]c3)c2)n1	InChI=1S/C29H32N6O3/c1-38-20-26-13-7-15-34(26)27(36)14-6-10-24-19-35(25-11-3-2-4-12-25)29(32-24)33-28(37)22-9-5-8-21(16-22)23-17-30-31-18-23/h2-5,8-9,11-12,16-19,26H,6-7,10,13-15,20H2,1H3,(H,30,31)(H,32,33,37)	JSPNBUSPPOKDPY-UHFFFAOYSA-N	479169	US12534452, Example 55	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479169	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479169&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			138624281	442138738							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217365	COC[C@H]1CCCN1C(=O)CCCc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3cn[nH]c3)c2)n1	InChI=1S/C29H32N6O3/c1-38-20-26-13-7-15-34(26)27(36)14-6-10-24-19-35(25-11-3-2-4-12-25)29(32-24)33-28(37)22-9-5-8-21(16-22)23-17-30-31-18-23/h2-5,8-9,11-12,16-19,26H,6-7,10,13-15,20H2,1H3,(H,30,31)(H,32,33,37)	JSPNBUSPPOKDPY-UHFFFAOYSA-N	479170	US12534452, Example 56	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479170	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479170&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130342049	442138739							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217366	O=C(O)CCCc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3cn[nH]c3)c2)n1	InChI=1S/C23H21N5O3/c29-21(30)11-5-8-19-15-28(20-9-2-1-3-10-20)23(26-19)27-22(31)17-7-4-6-16(12-17)18-13-24-25-14-18/h1-4,6-7,9-10,12-15H,5,8,11H2,(H,24,25)(H,29,30)(H,26,27,31)	BQLNHANSAUQAQD-UHFFFAOYSA-N	479171	US12534452, Example 57	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479171	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479171&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130341502	442138740							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217367	COC(=O)CCCc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3cn[nH]c3)c2)n1	InChI=1S/C24H23N5O3/c1-32-22(30)12-6-9-20-16-29(21-10-3-2-4-11-21)24(27-20)28-23(31)18-8-5-7-17(13-18)19-14-25-26-15-19/h2-5,7-8,10-11,13-16H,6,9,12H2,1H3,(H,25,26)(H,27,28,31)	AGLYIUNLXQZLHJ-UHFFFAOYSA-N	479172	US12534452, Example 58	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479172	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479172&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130341510	442138741							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217368	O=C(Nc1nc(CCCC(=O)N2CCCCC2)cn1-c1ccccc1)c1cccc(-c2cn[nH]c2)c1	InChI=1S/C28H30N6O2/c35-26(33-15-5-2-6-16-33)14-8-11-24-20-34(25-12-3-1-4-13-25)28(31-24)32-27(36)22-10-7-9-21(17-22)23-18-29-30-19-23/h1,3-4,7,9-10,12-13,17-20H,2,5-6,8,11,14-16H2,(H,29,30)(H,31,32,36)	BLWLHGIQAFNSLH-UHFFFAOYSA-N	479173	US12534452, Example 59	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479173	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479173&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			141660150	442138742							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217369	CNC(=O)CCCc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3cn[nH]c3)c2)n1	InChI=1S/C24H24N6O2/c1-25-22(31)12-6-9-20-16-30(21-10-3-2-4-11-21)24(28-20)29-23(32)18-8-5-7-17(13-18)19-14-26-27-15-19/h2-5,7-8,10-11,13-16H,6,9,12H2,1H3,(H,25,31)(H,26,27)(H,28,29,32)	LHCIRXCWJNSTJL-UHFFFAOYSA-N	479174	US12534452, Example 60	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479174	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479174&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130341625	442138743							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217370	C[C@@H]1CCCCN1C(=O)CCCc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3cn[nH]c3)c2)n1	InChI=1S/C29H32N6O2/c1-21-9-5-6-16-34(21)27(36)15-8-12-25-20-35(26-13-3-2-4-14-26)29(32-25)33-28(37)23-11-7-10-22(17-23)24-18-30-31-19-24/h2-4,7,10-11,13-14,17-21H,5-6,8-9,12,15-16H2,1H3,(H,30,31)(H,32,33,37)	QTQBQHPQRQATCY-UHFFFAOYSA-N	479175	US12534452, Example 61	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479175	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479175&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130341509	442138744							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217371	C[C@H]1CCCCN1C(=O)CCCc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3cn[nH]c3)c2)n1	InChI=1S/C29H32N6O2/c1-21-9-5-6-16-34(21)27(36)15-8-12-25-20-35(26-13-3-2-4-14-26)29(32-25)33-28(37)23-11-7-10-22(17-23)24-18-30-31-19-24/h2-4,7,10-11,13-14,17-21H,5-6,8-9,12,15-16H2,1H3,(H,30,31)(H,32,33,37)	QTQBQHPQRQATCY-UHFFFAOYSA-N	479176	US12534452, Example 62	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479176	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479176&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			138624249	442138745							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217372	C[C@@H]1CCC[C@H](C)N1C(=O)CCCc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3cn[nH]c3)c2)n1	InChI=1S/C30H34N6O2/c1-21-9-6-10-22(2)36(21)28(37)16-8-13-26-20-35(27-14-4-3-5-15-27)30(33-26)34-29(38)24-12-7-11-23(17-24)25-18-31-32-19-25/h3-5,7,11-12,14-15,17-22H,6,8-10,13,16H2,1-2H3,(H,31,32)(H,33,34,38)	YPDPUQHNMCFNFO-UHFFFAOYSA-N	479177	US12534452, Example 63	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479177	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479177&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130341520	442138746							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217373	O=C(CCCc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3cn[nH]c3)c2)n1)Nc1ccc(F)cc1	InChI=1S/C29H25FN6O2/c30-23-12-14-24(15-13-23)33-27(37)11-5-8-25-19-36(26-9-2-1-3-10-26)29(34-25)35-28(38)21-7-4-6-20(16-21)22-17-31-32-18-22/h1-4,6-7,9-10,12-19H,5,8,11H2,(H,31,32)(H,33,37)(H,34,35,38)	XPSXVMVUMMMGLZ-UHFFFAOYSA-N	479178	US12534452, Example 64	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479178	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479178&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130341610	442138747							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217374	O=C(CCCc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3cn[nH]c3)c2)n1)Nc1ccccc1F	InChI=1S/C29H25FN6O2/c30-25-13-4-5-14-26(25)34-27(37)15-7-10-23-19-36(24-11-2-1-3-12-24)29(33-23)35-28(38)21-9-6-8-20(16-21)22-17-31-32-18-22/h1-6,8-9,11-14,16-19H,7,10,15H2,(H,31,32)(H,34,37)(H,33,35,38)	JWDYKHBEGKOLPB-UHFFFAOYSA-N	479179	US12534452, Example 65	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479179	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479179&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			138624280	442138748							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217375	O=C(CCCc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3cn[nH]c3)c2)n1)Nc1ccc(F)cc1F	InChI=1S/C29H24F2N6O2/c30-22-12-13-26(25(31)15-22)35-27(38)11-5-8-23-18-37(24-9-2-1-3-10-24)29(34-23)36-28(39)20-7-4-6-19(14-20)21-16-32-33-17-21/h1-4,6-7,9-10,12-18H,5,8,11H2,(H,32,33)(H,35,38)(H,34,36,39)	XFFJPVWJZBZJEE-UHFFFAOYSA-N	479180	US12534452, Example 66	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479180	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479180&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130341811	442138749							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217376	C[Si](C)(C)CCOCn1cc(-c2cccc(C(=O)Nc3nc(CCCC(=O)NC4CC4)cn3-c3ccccc3)c2)cn1	InChI=1S/C32H40N6O3Si/c1-42(2,3)18-17-41-23-37-21-26(20-33-37)24-9-7-10-25(19-24)31(40)36-32-35-28(11-8-14-30(39)34-27-15-16-27)22-38(32)29-12-5-4-6-13-29/h4-7,9-10,12-13,19-22,27H,8,11,14-18,23H2,1-3H3,(H,34,39)(H,35,36,40)	LOGWAURYFJQMFH-UHFFFAOYSA-N	479181	US12534452, Example 67	Interleukin-1 receptor-associated kinase 4	Homo sapiens		>100							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479181	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479181&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130341810	442138750							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217377	O=C(CCCc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3cn[nH]c3)c2)n1)NC1CC1	InChI=1S/C26H26N6O2/c33-24(29-21-12-13-21)11-5-8-22-17-32(23-9-2-1-3-10-23)26(30-22)31-25(34)19-7-4-6-18(14-19)20-15-27-28-16-20/h1-4,6-7,9-10,14-17,21H,5,8,11-13H2,(H,27,28)(H,29,33)(H,30,31,34)	KGUYZSNRJSUCMO-UHFFFAOYSA-N	479182	US12534452, Example 68	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479182	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479182&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			138624084	442138751							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217378	O=C(CCCc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3cn[nH]c3)c2)n1)NC1CCC1	InChI=1S/C27H28N6O2/c34-25(30-22-9-5-10-22)14-6-11-23-18-33(24-12-2-1-3-13-24)27(31-23)32-26(35)20-8-4-7-19(15-20)21-16-28-29-17-21/h1-4,7-8,12-13,15-18,22H,5-6,9-11,14H2,(H,28,29)(H,30,34)(H,31,32,35)	FPIIYKQEZWENBH-UHFFFAOYSA-N	479183	US12534452, Example 69	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479183	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479183&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			138624390	442138752							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217379	CC(C)OC(=O)CCCc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3cn[nH]c3)c2)n1	InChI=1S/C26H27N5O3/c1-18(2)34-24(32)13-7-10-22-17-31(23-11-4-3-5-12-23)26(29-22)30-25(33)20-9-6-8-19(14-20)21-15-27-28-16-21/h3-6,8-9,11-12,14-18H,7,10,13H2,1-2H3,(H,27,28)(H,29,30,33)	OPGDDJQOUWXKTB-UHFFFAOYSA-N	479184	US12534452, Example 70	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479184	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479184&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			138624140	442138753							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217380	CN(C(=O)CCCc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3cn[nH]c3)c2)n1)C1CC1	InChI=1S/C27H28N6O2/c1-32(23-13-14-23)25(34)12-6-9-22-18-33(24-10-3-2-4-11-24)27(30-22)31-26(35)20-8-5-7-19(15-20)21-16-28-29-17-21/h2-5,7-8,10-11,15-18,23H,6,9,12-14H2,1H3,(H,28,29)(H,30,31,35)	QXYVVKCZOZCLBP-UHFFFAOYSA-N	479185	US12534452, Example 71	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479185	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479185&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			138624389	442138754							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217381	CCOC(C)n1cc(-c2cccc(C(=O)Nc3nc(CCCC(=O)NC4CC4)cn3-c3ccccc3)c2)cn1	InChI=1S/C30H34N6O3/c1-3-39-21(2)36-19-24(18-31-36)22-9-7-10-23(17-22)29(38)34-30-33-26(11-8-14-28(37)32-25-15-16-25)20-35(30)27-12-5-4-6-13-27/h4-7,9-10,12-13,17-21,25H,3,8,11,14-16H2,1-2H3,(H,32,37)(H,33,34,38)	RTBRZASAUFHFDP-UHFFFAOYSA-N	479186	US12534452, Example 72	Interleukin-1 receptor-associated kinase 4	Homo sapiens		>100							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479186	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479186&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130342224	442138755							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217382	CCOC(C)(C)n1cc(-c2cccc(C(=O)Nc3nc(CCCC(=O)NC4CC4)cn3-c3ccccc3)c2)cn1	InChI=1S/C31H36N6O3/c1-4-40-31(2,3)37-20-24(19-32-37)22-10-8-11-23(18-22)29(39)35-30-34-26(12-9-15-28(38)33-25-16-17-25)21-36(30)27-13-6-5-7-14-27/h5-8,10-11,13-14,18-21,25H,4,9,12,15-17H2,1-3H3,(H,33,38)(H,34,35,39)	ZFTBLGVYEGLNAA-UHFFFAOYSA-N	479187	US12534452, Example 73	Interleukin-1 receptor-associated kinase 4	Homo sapiens		 75							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479187	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479187&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130342236	442138756							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217383	O=C(CCCCc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3cn[nH]c3)c2)n1)Nc1ccccc1	InChI=1S/C30H28N6O2/c37-28(33-25-12-3-1-4-13-25)17-8-7-14-26-21-36(27-15-5-2-6-16-27)30(34-26)35-29(38)23-11-9-10-22(18-23)24-19-31-32-20-24/h1-6,9-13,15-16,18-21H,7-8,14,17H2,(H,31,32)(H,33,37)(H,34,35,38)	ODPRTEFROJCFBX-UHFFFAOYSA-N	479188	US12534452, Example 76	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479188	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479188&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130342056	442138757							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217384	COC(=O)CCCCc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3cn[nH]c3)c2)n1	InChI=1S/C25H25N5O3/c1-33-23(31)13-6-5-10-21-17-30(22-11-3-2-4-12-22)25(28-21)29-24(32)19-9-7-8-18(14-19)20-15-26-27-16-20/h2-4,7-9,11-12,14-17H,5-6,10,13H2,1H3,(H,26,27)(H,28,29,32)	GSIRVCMQWRYTNQ-UHFFFAOYSA-N	479189	US12534452, Example 77	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479189	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479189&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130342235	442138758							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217385	O=C(O)CCCCc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3cn[nH]c3)c2)n1	InChI=1S/C24H23N5O3/c30-22(31)12-5-4-9-20-16-29(21-10-2-1-3-11-21)24(27-20)28-23(32)18-8-6-7-17(13-18)19-14-25-26-15-19/h1-3,6-8,10-11,13-16H,4-5,9,12H2,(H,25,26)(H,30,31)(H,27,28,32)	BCQTXJUQXNAJCP-UHFFFAOYSA-N	479190	US12534452, Example 78	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479190	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479190&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			138624253	442138759							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217386	O=C(Nc1nc(CCCCC(=O)N2CCCCC2)cn1-c1ccccc1)c1cccc(-c2cn[nH]c2)c1	InChI=1S/C29H32N6O2/c36-27(34-16-7-2-8-17-34)15-6-5-12-25-21-35(26-13-3-1-4-14-26)29(32-25)33-28(37)23-11-9-10-22(18-23)24-19-30-31-20-24/h1,3-4,9-11,13-14,18-21H,2,5-8,12,15-17H2,(H,30,31)(H,32,33,37)	VMYIZYGLAMQMEE-UHFFFAOYSA-N	479191	US12534452, Example 79	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479191	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479191&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130341790	442138760							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217387	CNC(=O)CCCCc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3cn[nH]c3)c2)n1	InChI=1S/C25H26N6O2/c1-26-23(32)13-6-5-10-21-17-31(22-11-3-2-4-12-22)25(29-21)30-24(33)19-9-7-8-18(14-19)20-15-27-28-16-20/h2-4,7-9,11-12,14-17H,5-6,10,13H2,1H3,(H,26,32)(H,27,28)(H,29,30,33)	ASYZFSVCKQERGU-UHFFFAOYSA-N	479192	US12534452, Example 80	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479192	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479192&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			138624146	442138761							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217388	C[C@@H]1CCC[C@H](C)N1C(=O)CCCCc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3cn[nH]c3)c2)n1	InChI=1S/C31H36N6O2/c1-22-10-8-11-23(2)37(22)29(38)17-7-6-14-27-21-36(28-15-4-3-5-16-28)31(34-27)35-30(39)25-13-9-12-24(18-25)26-19-32-33-20-26/h3-5,9,12-13,15-16,18-23H,6-8,10-11,14,17H2,1-2H3,(H,32,33)(H,34,35,39)	DFEFLHAQNWZVQM-UHFFFAOYSA-N	479193	US12534452, Example 81	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479193	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479193&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			141660144	442138762							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217389	C[C@H]1CCCCN1C(=O)CCCCc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3cn[nH]c3)c2)n1	InChI=1S/C30H34N6O2/c1-22-10-7-8-17-35(22)28(37)16-6-5-13-26-21-36(27-14-3-2-4-15-27)30(33-26)34-29(38)24-12-9-11-23(18-24)25-19-31-32-20-25/h2-4,9,11-12,14-15,18-22H,5-8,10,13,16-17H2,1H3,(H,31,32)(H,33,34,38)	LQYLUCGDEYHLRA-UHFFFAOYSA-N	479194	US12534452, Example 82	Interleukin-1 receptor-associated kinase 4	Homo sapiens		 75							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479194	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479194&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130342270	442138763							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217390	C[C@@H]1CCCCN1C(=O)CCCCc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3cn[nH]c3)c2)n1	InChI=1S/C30H34N6O2/c1-22-10-7-8-17-35(22)28(37)16-6-5-13-26-21-36(27-14-3-2-4-15-27)30(33-26)34-29(38)24-12-9-11-23(18-24)25-19-31-32-20-25/h2-4,9,11-12,14-15,18-22H,5-8,10,13,16-17H2,1H3,(H,31,32)(H,33,34,38)	LQYLUCGDEYHLRA-UHFFFAOYSA-N	479195	US12534452, Example 83	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479195	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479195&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130342240	442138764							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217391	COC[C@@H]1CCCN1NC(=O)CCCCc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3cn[nH]c3)c2)n1	InChI=1S/C30H35N7O3/c1-40-21-27-14-8-16-37(27)35-28(38)15-6-5-11-25-20-36(26-12-3-2-4-13-26)30(33-25)34-29(39)23-10-7-9-22(17-23)24-18-31-32-19-24/h2-4,7,9-10,12-13,17-20,27H,5-6,8,11,14-16,21H2,1H3,(H,31,32)(H,35,38)(H,33,34,39)	NBAUYFJRLIPKNR-UHFFFAOYSA-N	479196	US12534452, Example 84	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479196	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479196&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130342101	442138765							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217392	COC[C@H]1CCCN1NC(=O)CCCCc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3cn[nH]c3)c2)n1	InChI=1S/C30H35N7O3/c1-40-21-27-14-8-16-37(27)35-28(38)15-6-5-11-25-20-36(26-12-3-2-4-13-26)30(33-25)34-29(39)23-10-7-9-22(17-23)24-18-31-32-19-24/h2-4,7,9-10,12-13,17-20,27H,5-6,8,11,14-16,21H2,1H3,(H,31,32)(H,35,38)(H,33,34,39)	NBAUYFJRLIPKNR-UHFFFAOYSA-N	479197	US12534452, Example 85	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479197	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479197&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130342092	442138766							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217393	COC[C@@H]1CCCN1C(=O)CCCCc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3cn[nH]c3)c2)n1	InChI=1S/C30H34N6O3/c1-39-21-27-14-8-16-35(27)28(37)15-6-5-11-25-20-36(26-12-3-2-4-13-26)30(33-25)34-29(38)23-10-7-9-22(17-23)24-18-31-32-19-24/h2-4,7,9-10,12-13,17-20,27H,5-6,8,11,14-16,21H2,1H3,(H,31,32)(H,33,34,38)	FPLBETQYDVVFFU-UHFFFAOYSA-N	479198	US12534452, Example 86	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479198	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479198&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130341516	442138767							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217394	COC[C@H]1CCCN1C(=O)CCCCc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3cn[nH]c3)c2)n1	InChI=1S/C30H34N6O3/c1-39-21-27-14-8-16-35(27)28(37)15-6-5-11-25-20-36(26-12-3-2-4-13-26)30(33-25)34-29(38)23-10-7-9-22(17-23)24-18-31-32-19-24/h2-4,7,9-10,12-13,17-20,27H,5-6,8,11,14-16,21H2,1H3,(H,31,32)(H,33,34,38)	FPLBETQYDVVFFU-UHFFFAOYSA-N	479199	US12534452, Example 87	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479199	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479199&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130341505	442138768							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217395	O=C(CCCCc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3cn[nH]c3)c2)n1)NC1CC1	InChI=1S/C27H28N6O2/c34-25(30-22-13-14-22)12-5-4-9-23-18-33(24-10-2-1-3-11-24)27(31-23)32-26(35)20-8-6-7-19(15-20)21-16-28-29-17-21/h1-3,6-8,10-11,15-18,22H,4-5,9,12-14H2,(H,28,29)(H,30,34)(H,31,32,35)	ZPPJZXHSAGVBBM-UHFFFAOYSA-N	479200	US12534452, Example 88	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479200	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479200&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130342044	442138769							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217396	O=C(CCCCc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3cn[nH]c3)c2)n1)NC1CCCCC1	InChI=1S/C30H34N6O2/c37-28(33-25-12-3-1-4-13-25)17-8-7-14-26-21-36(27-15-5-2-6-16-27)30(34-26)35-29(38)23-11-9-10-22(18-23)24-19-31-32-20-24/h2,5-6,9-11,15-16,18-21,25H,1,3-4,7-8,12-14,17H2,(H,31,32)(H,33,37)(H,34,35,38)	VKJUEMJGDOOPAQ-UHFFFAOYSA-N	479201	US12534452, Example 89	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479201	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479201&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130342043	442138770							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217397	O=C(CCCCCc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3cn[nH]c3)c2)n1)Nc1ccccc1	InChI=1S/C31H30N6O2/c38-29(34-26-13-4-1-5-14-26)18-9-2-6-15-27-22-37(28-16-7-3-8-17-28)31(35-27)36-30(39)24-12-10-11-23(19-24)25-20-32-33-21-25/h1,3-5,7-8,10-14,16-17,19-22H,2,6,9,15,18H2,(H,32,33)(H,34,38)(H,35,36,39)	WXEXBRJTUPTSDD-UHFFFAOYSA-N	479202	US12534452, Example 90	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479202	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479202&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130341798	442138771							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217398	COC(=O)CCCCCc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3cn[nH]c3)c2)n1	InChI=1S/C26H27N5O3/c1-34-24(32)14-7-2-4-11-22-18-31(23-12-5-3-6-13-23)26(29-22)30-25(33)20-10-8-9-19(15-20)21-16-27-28-17-21/h3,5-6,8-10,12-13,15-18H,2,4,7,11,14H2,1H3,(H,27,28)(H,29,30,33)	HLKAKKXNNUMXCK-UHFFFAOYSA-N	479203	US12534452, Example 91	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479203	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479203&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130342228	442138772							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217399	O=C(O)CCCCCc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3cn[nH]c3)c2)n1	InChI=1S/C25H25N5O3/c31-23(32)13-6-1-3-10-21-17-30(22-11-4-2-5-12-22)25(28-21)29-24(33)19-9-7-8-18(14-19)20-15-26-27-16-20/h2,4-5,7-9,11-12,14-17H,1,3,6,10,13H2,(H,26,27)(H,31,32)(H,28,29,33)	NGBMHMZIUCRJQS-UHFFFAOYSA-N	479204	US12534452, Example 92	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479204	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479204&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130342096	442138773							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217400	O=C(Nc1nc(CCCCCC(=O)N2CCCCC2)cn1-c1ccccc1)c1cccc(-c2cn[nH]c2)c1	InChI=1S/C30H34N6O2/c37-28(35-17-8-3-9-18-35)16-7-1-4-13-26-22-36(27-14-5-2-6-15-27)30(33-26)34-29(38)24-12-10-11-23(19-24)25-20-31-32-21-25/h2,5-6,10-12,14-15,19-22H,1,3-4,7-9,13,16-18H2,(H,31,32)(H,33,34,38)	AGAKNVYQHMBKBS-UHFFFAOYSA-N	479205	US12534452, Example 93	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479205	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479205&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130341823	442138774							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217401	CNC(=O)CCCCCc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3cn[nH]c3)c2)n1	InChI=1S/C26H28N6O2/c1-27-24(33)14-7-2-4-11-22-18-32(23-12-5-3-6-13-23)26(30-22)31-25(34)20-10-8-9-19(15-20)21-16-28-29-17-21/h3,5-6,8-10,12-13,15-18H,2,4,7,11,14H2,1H3,(H,27,33)(H,28,29)(H,30,31,34)	AMUQRPGLCZYAAR-UHFFFAOYSA-N	479206	US12534452, Example 94	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479206	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479206&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130341822	442138775							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217402	C[C@H]1CCCCN1C(=O)CCCCCc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3cn[nH]c3)c2)n1	InChI=1S/C31H36N6O2/c1-23-11-8-9-18-36(23)29(38)17-7-2-4-14-27-22-37(28-15-5-3-6-16-28)31(34-27)35-30(39)25-13-10-12-24(19-25)26-20-32-33-21-26/h3,5-6,10,12-13,15-16,19-23H,2,4,7-9,11,14,17-18H2,1H3,(H,32,33)(H,34,35,39)	YURDYIFQPRGWBM-UHFFFAOYSA-N	479207	US12534452, Example 95	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479207	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479207&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130341821	442138776							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217403	C[C@@H]1CCCCN1C(=O)CCCCCc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3cn[nH]c3)c2)n1	InChI=1S/C31H36N6O2/c1-23-11-8-9-18-36(23)29(38)17-7-2-4-14-27-22-37(28-15-5-3-6-16-28)31(34-27)35-30(39)25-13-10-12-24(19-25)26-20-32-33-21-26/h3,5-6,10,12-13,15-16,19-23H,2,4,7-9,11,14,17-18H2,1H3,(H,32,33)(H,34,35,39)	YURDYIFQPRGWBM-UHFFFAOYSA-N	479208	US12534452, Example 96	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479208	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479208&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130342050	442138777							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217404	C[C@@H]1CCC[C@H](C)N1C(=O)CCCCCc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3cn[nH]c3)c2)n1	InChI=1S/C32H38N6O2/c1-23-11-9-12-24(2)38(23)30(39)18-8-3-5-15-28-22-37(29-16-6-4-7-17-29)32(35-28)36-31(40)26-14-10-13-25(19-26)27-20-33-34-21-27/h4,6-7,10,13-14,16-17,19-24H,3,5,8-9,11-12,15,18H2,1-2H3,(H,33,34)(H,35,36,40)	ZSQJBTXMUVVQRG-UHFFFAOYSA-N	479209	US12534452, Example 97	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479209	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479209&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			141660139	442138778							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217405	COC[C@@H]1CCCN1NC(=O)CCCCCc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3cn[nH]c3)c2)n1	InChI=1S/C31H37N7O3/c1-41-22-28-15-9-17-38(28)36-29(39)16-7-2-4-12-26-21-37(27-13-5-3-6-14-27)31(34-26)35-30(40)24-11-8-10-23(18-24)25-19-32-33-20-25/h3,5-6,8,10-11,13-14,18-21,28H,2,4,7,9,12,15-17,22H2,1H3,(H,32,33)(H,36,39)(H,34,35,40)	DUYNICFUSSJEPJ-UHFFFAOYSA-N	479210	US12534452, Example 98	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479210	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479210&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130342234	442138779							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217406	COC[C@H]1CCCN1NC(=O)CCCCCc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3cn[nH]c3)c2)n1	InChI=1S/C31H37N7O3/c1-41-22-28-15-9-17-38(28)36-29(39)16-7-2-4-12-26-21-37(27-13-5-3-6-14-27)31(34-26)35-30(40)24-11-8-10-23(18-24)25-19-32-33-20-25/h3,5-6,8,10-11,13-14,18-21,28H,2,4,7,9,12,15-17,22H2,1H3,(H,32,33)(H,36,39)(H,34,35,40)	DUYNICFUSSJEPJ-UHFFFAOYSA-N	479211	US12534452, Example 99	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479211	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479211&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			141660147	442138780							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217407	COC[C@@H]1CCCN1C(=O)CCCCCc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3cn[nH]c3)c2)n1	InChI=1S/C31H36N6O3/c1-40-22-28-15-9-17-36(28)29(38)16-7-2-4-12-26-21-37(27-13-5-3-6-14-27)31(34-26)35-30(39)24-11-8-10-23(18-24)25-19-32-33-20-25/h3,5-6,8,10-11,13-14,18-21,28H,2,4,7,9,12,15-17,22H2,1H3,(H,32,33)(H,34,35,39)	CDARFOVZOHJOOC-UHFFFAOYSA-N	479212	US12534452, Example 100	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479212	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479212&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130342230	442138781							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217408	COC[C@H]1CCCN1C(=O)CCCCCc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3cn[nH]c3)c2)n1	InChI=1S/C31H36N6O3/c1-40-22-28-15-9-17-36(28)29(38)16-7-2-4-12-26-21-37(27-13-5-3-6-14-27)31(34-26)35-30(39)24-11-8-10-23(18-24)25-19-32-33-20-25/h3,5-6,8,10-11,13-14,18-21,28H,2,4,7,9,12,15-17,22H2,1H3,(H,32,33)(H,34,35,39)	CDARFOVZOHJOOC-UHFFFAOYSA-N	479213	US12534452, Example 101	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479213	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479213&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			138624411	442138782							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217409	O=C(Nc1nc(CCCCCCN2CCCCC2)cn1-c1ccccc1)c1cccc(-c2cn[nH]c2)c1	InChI=1S/C30H36N6O/c37-29(25-13-11-12-24(20-25)26-21-31-32-22-26)34-30-33-27(23-36(30)28-15-6-3-7-16-28)14-5-1-2-8-17-35-18-9-4-10-19-35/h3,6-7,11-13,15-16,20-23H,1-2,4-5,8-10,14,17-19H2,(H,31,32)(H,33,34,37)	RSMRLZHROSYCBW-UHFFFAOYSA-N	479214	US12534452, Example 102	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479214	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479214&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			141660132	442138783							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217410	O=C(Nc1nc(CCO)cn1-c1ccccc1)c1cccc(-c2cn[nH]c2)c1	InChI=1S/C21H19N5O2/c27-10-9-18-14-26(19-7-2-1-3-8-19)21(24-18)25-20(28)16-6-4-5-15(11-16)17-12-22-23-13-17/h1-8,11-14,27H,9-10H2,(H,22,23)(H,24,25,28)	XQTFBHGEXWOHFK-UHFFFAOYSA-N	479215	US12534452, Example 103	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479215	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479215&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130341820	442138784							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217411	O=C(Nc1nc(CCN2CCCCC2)cn1-c1ccccc1)c1cccc(-c2cn[nH]c2)c1	InChI=1S/C26H28N6O/c33-25(21-9-7-8-20(16-21)22-17-27-28-18-22)30-26-29-23(12-15-31-13-5-2-6-14-31)19-32(26)24-10-3-1-4-11-24/h1,3-4,7-11,16-19H,2,5-6,12-15H2,(H,27,28)(H,29,30,33)	CWNMZRCHAFKRFN-UHFFFAOYSA-N	479216	US12534452, Example 104	Interleukin-1 receptor-associated kinase 4	Homo sapiens		>100							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479216	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479216&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			138624118	442138785							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217412	O=C(Nc1nc(CCCO)cn1-c1ccccc1)c1cccc(-c2cn[nH]c2)c1	InChI=1S/C22H21N5O2/c28-11-5-8-19-15-27(20-9-2-1-3-10-20)22(25-19)26-21(29)17-7-4-6-16(12-17)18-13-23-24-14-18/h1-4,6-7,9-10,12-15,28H,5,8,11H2,(H,23,24)(H,25,26,29)	MRQHRUWAFXKARR-UHFFFAOYSA-N	479217	US12534452, Example 105	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479217	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479217&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130341631	442138786							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217413	O=C(Nc1nc(CCCN2CCCCC2)cn1-c1ccccc1)c1cccc(-c2cn[nH]c2)c1	InChI=1S/C27H30N6O/c34-26(22-10-7-9-21(17-22)23-18-28-29-19-23)31-27-30-24(11-8-16-32-14-5-2-6-15-32)20-33(27)25-12-3-1-4-13-25/h1,3-4,7,9-10,12-13,17-20H,2,5-6,8,11,14-16H2,(H,28,29)(H,30,31,34)	DXOTXGOIFWBHKE-UHFFFAOYSA-N	479218	US12534452, Example 106	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479218	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479218&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			138624376	442138787							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217414	O=C(Nc1nc(CCCN2CCOCC2)cn1-c1ccccc1)c1cccc(-c2cn[nH]c2)c1	InChI=1S/C26H28N6O2/c33-25(21-7-4-6-20(16-21)22-17-27-28-18-22)30-26-29-23(8-5-11-31-12-14-34-15-13-31)19-32(26)24-9-2-1-3-10-24/h1-4,6-7,9-10,16-19H,5,8,11-15H2,(H,27,28)(H,29,30,33)	DKKHBMKFUWIVNB-UHFFFAOYSA-N	479219	US12534452, Example 107	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479219	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479219&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			138624394	442138788							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217415	CN1CCN(CCCc2cn(-c3ccccc3)c(NC(=O)c3cccc(-c4cn[nH]c4)c3)n2)CC1	InChI=1S/C27H31N7O/c1-32-13-15-33(16-14-32)12-6-9-24-20-34(25-10-3-2-4-11-25)27(30-24)31-26(35)22-8-5-7-21(17-22)23-18-28-29-19-23/h2-5,7-8,10-11,17-20H,6,9,12-16H2,1H3,(H,28,29)(H,30,31,35)	VJADMWSLUDXENZ-UHFFFAOYSA-N	479220	US12534452, Example 108	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479220	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479220&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130341812	442138789							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217416	O=C(Nc1nc(CCCNc2ccccc2)cn1-c1ccccc1)c1cccc(-c2cn[nH]c2)c1	InChI=1S/C28H26N6O/c35-27(22-10-7-9-21(17-22)23-18-30-31-19-23)33-28-32-25(20-34(28)26-14-5-2-6-15-26)13-8-16-29-24-11-3-1-4-12-24/h1-7,9-12,14-15,17-20,29H,8,13,16H2,(H,30,31)(H,32,33,35)	DJJYVRNQVPIJMI-UHFFFAOYSA-N	479221	US12534452, Example 109	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479221	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479221&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130341788	442138790							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217417	O=C(Nc1nc(CCCN2CCSCC2)cn1-c1ccccc1)c1cccc(-c2cn[nH]c2)c1	InChI=1S/C26H28N6OS/c33-25(21-7-4-6-20(16-21)22-17-27-28-18-22)30-26-29-23(8-5-11-31-12-14-34-15-13-31)19-32(26)24-9-2-1-3-10-24/h1-4,6-7,9-10,16-19H,5,8,11-15H2,(H,27,28)(H,29,30,33)	GBCIYIADMAMSOT-UHFFFAOYSA-N	479222	US12534452, Example 110	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479222	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479222&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130342226	442138791							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217418	O=C(Nc1nc(CCCCO)cn1-c1ccccc1)c1cccc(-c2cn[nH]c2)c1	InChI=1S/C23H23N5O2/c29-12-5-4-9-20-16-28(21-10-2-1-3-11-21)23(26-20)27-22(30)18-8-6-7-17(13-18)19-14-24-25-15-19/h1-3,6-8,10-11,13-16,29H,4-5,9,12H2,(H,24,25)(H,26,27,30)	KGRHVTYNBJIHFF-UHFFFAOYSA-N	479223	US12534452, Example 111	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479223	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479223&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130341799	442138792							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217419	O=C(Nc1nc(CCCCNc2ccccc2)cn1-c1ccccc1)c1cccc(-c2cn[nH]c2)c1	InChI=1S/C29H28N6O/c36-28(23-11-9-10-22(18-23)24-19-31-32-20-24)34-29-33-26(21-35(29)27-15-5-2-6-16-27)14-7-8-17-30-25-12-3-1-4-13-25/h1-6,9-13,15-16,18-21,30H,7-8,14,17H2,(H,31,32)(H,33,34,36)	MJXPPSDQNMRFLR-UHFFFAOYSA-N	479224	US12534452, Example 112	Interleukin-1 receptor-associated kinase 4	Homo sapiens		>100							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479224	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479224&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130342239	442138793							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217420	O=C(Nc1nc(CCCCN2CCCCC2)cn1-c1ccccc1)c1cccc(-c2cn[nH]c2)c1	InChI=1S/C28H32N6O/c35-27(23-11-9-10-22(18-23)24-19-29-30-20-24)32-28-31-25(21-34(28)26-13-3-1-4-14-26)12-5-8-17-33-15-6-2-7-16-33/h1,3-4,9-11,13-14,18-21H,2,5-8,12,15-17H2,(H,29,30)(H,31,32,35)	NLBNZPCXAUJHAV-UHFFFAOYSA-N	479225	US12534452, Example 113	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479225	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479225&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			138624231	442138794							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217421	O=C(Nc1nc(CCCCN2CCOCC2)cn1-c1ccccc1)c1cccc(-c2cn[nH]c2)c1	InChI=1S/C27H30N6O2/c34-26(22-8-6-7-21(17-22)23-18-28-29-19-23)31-27-30-24(20-33(27)25-10-2-1-3-11-25)9-4-5-12-32-13-15-35-16-14-32/h1-3,6-8,10-11,17-20H,4-5,9,12-16H2,(H,28,29)(H,30,31,34)	PKCLDMRXDNYPHE-UHFFFAOYSA-N	479226	US12534452, Example 114	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479226	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479226&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130341776	442138795							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217422	O=C(Nc1nc(CCCCN2CCSCC2)cn1-c1ccccc1)c1cccc(-c2cn[nH]c2)c1	InChI=1S/C27H30N6OS/c34-26(22-8-6-7-21(17-22)23-18-28-29-19-23)31-27-30-24(20-33(27)25-10-2-1-3-11-25)9-4-5-12-32-13-15-35-16-14-32/h1-3,6-8,10-11,17-20H,4-5,9,12-16H2,(H,28,29)(H,30,31,34)	LOUJZPUOIJYJNE-UHFFFAOYSA-N	479227	US12534452, Example 115	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479227	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479227&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130341546	442138796							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217423	O=C(Nc1nc(CCCCCO)cn1-c1ccccc1)c1cccc(-c2cn[nH]c2)c1	InChI=1S/C24H25N5O2/c30-13-6-2-3-10-21-17-29(22-11-4-1-5-12-22)24(27-21)28-23(31)19-9-7-8-18(14-19)20-15-25-26-16-20/h1,4-5,7-9,11-12,14-17,30H,2-3,6,10,13H2,(H,25,26)(H,27,28,31)	JMCAFRXJOYHYDQ-UHFFFAOYSA-N	479228	US12534452, Example 116	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479228	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479228&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			138624085	442138797							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217424	O=C(Nc1nc(CCCCCNc2ccccc2)cn1-c1ccccc1)c1cccc(-c2cn[nH]c2)c1	InChI=1S/C30H30N6O/c37-29(24-12-10-11-23(19-24)25-20-32-33-21-25)35-30-34-27(22-36(30)28-16-7-2-8-17-28)15-6-3-9-18-31-26-13-4-1-5-14-26/h1-2,4-5,7-8,10-14,16-17,19-22,31H,3,6,9,15,18H2,(H,32,33)(H,34,35,37)	COMSUQBCYUCVSE-UHFFFAOYSA-N	479229	US12534452, Example 117	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479229	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479229&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130341662	442138798							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217425	O=C(Nc1nc(CCCCCN2CCCCC2)cn1-c1ccccc1)c1cccc(-c2cn[nH]c2)c1	InChI=1S/C29H34N6O/c36-28(24-12-10-11-23(19-24)25-20-30-31-21-25)33-29-32-26(22-35(29)27-14-5-1-6-15-27)13-4-2-7-16-34-17-8-3-9-18-34/h1,5-6,10-12,14-15,19-22H,2-4,7-9,13,16-18H2,(H,30,31)(H,32,33,36)	DDBDOEXFZQQGTJ-UHFFFAOYSA-N	479230	US12534452, Example 118	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479230	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479230&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			141660130	442138799							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217426	O=C(Nc1nc(CCCCCN2CCOCC2)cn1-c1ccccc1)c1cccc(-c2cn[nH]c2)c1	InChI=1S/C28H32N6O2/c35-27(23-9-7-8-22(18-23)24-19-29-30-20-24)32-28-31-25(21-34(28)26-11-4-1-5-12-26)10-3-2-6-13-33-14-16-36-17-15-33/h1,4-5,7-9,11-12,18-21H,2-3,6,10,13-17H2,(H,29,30)(H,31,32,35)	GPZLVABMHTVLKV-UHFFFAOYSA-N	479231	US12534452, Example 119	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479231	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479231&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130342237	442138800							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217427	O=C(Nc1nc(CCCCCN2CCSCC2)cn1-c1ccccc1)c1cccc(-c2cn[nH]c2)c1	InChI=1S/C28H32N6OS/c35-27(23-9-7-8-22(18-23)24-19-29-30-20-24)32-28-31-25(21-34(28)26-11-4-1-5-12-26)10-3-2-6-13-33-14-16-36-17-15-33/h1,4-5,7-9,11-12,18-21H,2-3,6,10,13-17H2,(H,29,30)(H,31,32,35)	QSHJCWKMGQUMMB-UHFFFAOYSA-N	479232	US12534452, Example 120	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479232	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479232&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			138624408	442138801							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217428	O=C(Nc1nc(CCCCCCO)cn1-c1ccccc1)c1cccc(-c2cn[nH]c2)c1	InChI=1S/C25H27N5O2/c31-14-7-2-1-4-11-22-18-30(23-12-5-3-6-13-23)25(28-22)29-24(32)20-10-8-9-19(15-20)21-16-26-27-17-21/h3,5-6,8-10,12-13,15-18,31H,1-2,4,7,11,14H2,(H,26,27)(H,28,29,32)	RVZNFFINXOIXEL-UHFFFAOYSA-N	479233	US12534452, Example 121	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479233	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479233&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130341791	442138802							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217429	O=C(Nc1nc(CCCCCCNc2ccccc2)cn1-c1ccccc1)c1cccc(-c2cn[nH]c2)c1	InChI=1S/C31H32N6O/c38-30(25-13-11-12-24(20-25)26-21-33-34-22-26)36-31-35-28(23-37(31)29-17-8-4-9-18-29)16-5-1-2-10-19-32-27-14-6-3-7-15-27/h3-4,6-9,11-15,17-18,20-23,32H,1-2,5,10,16,19H2,(H,33,34)(H,35,36,38)	VCSLEMHVIBFNPN-UHFFFAOYSA-N	479234	US12534452, Example 122	Interleukin-1 receptor-associated kinase 4	Homo sapiens		 75							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479234	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479234&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130341792	442138803							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217430	O=C(Nc1nc(CCCCCCN2CCOCC2)cn1-c1ccccc1)c1cccc(-c2cn[nH]c2)c1	InChI=1S/C29H34N6O2/c36-28(24-10-8-9-23(19-24)25-20-30-31-21-25)33-29-32-26(22-35(29)27-12-5-3-6-13-27)11-4-1-2-7-14-34-15-17-37-18-16-34/h3,5-6,8-10,12-13,19-22H,1-2,4,7,11,14-18H2,(H,30,31)(H,32,33,36)	BHGWGRWSHIVICT-UHFFFAOYSA-N	479235	US12534452, Example 123	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479235	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479235&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130341784	442138804							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217431	O=C(Nc1nc(CCCCCCN2CCSCC2)cn1-c1ccccc1)c1cccc(-c2cn[nH]c2)c1	InChI=1S/C29H34N6OS/c36-28(24-10-8-9-23(19-24)25-20-30-31-21-25)33-29-32-26(22-35(29)27-12-5-3-6-13-27)11-4-1-2-7-14-34-15-17-37-18-16-34/h3,5-6,8-10,12-13,19-22H,1-2,4,7,11,14-18H2,(H,30,31)(H,32,33,36)	HXJVJLWAMSLYLL-UHFFFAOYSA-N	479236	US12534452, Example 124	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479236	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479236&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130341658	442138805							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217432	O=C(Nc1nc(CCCCCC[N+]2([O-])CCCCC2)cn1-c1ccccc1)c1cccc(-c2cn[nH]c2)c1	InChI=1S/C30H36N6O2/c37-29(25-13-11-12-24(20-25)26-21-31-32-22-26)34-30-33-27(23-35(30)28-15-6-3-7-16-28)14-5-1-2-8-17-36(38)18-9-4-10-19-36/h3,6-7,11-13,15-16,20-23H,1-2,4-5,8-10,14,17-19H2,(H,31,32)(H,33,34,37)	LPNNBKWYPJOQFZ-UHFFFAOYSA-N	479237	US12534452, Example 125	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479237	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479237&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			138624234	442138806							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217433	O=C(Nc1nc(CCC[N+]2([O-])CCOCC2)cn1-c1ccccc1)c1cccc(-c2cn[nH]c2)c1	InChI=1S/C26H28N6O3/c33-25(21-7-4-6-20(16-21)22-17-27-28-18-22)30-26-29-23(19-31(26)24-9-2-1-3-10-24)8-5-11-32(34)12-14-35-15-13-32/h1-4,6-7,9-10,16-19H,5,8,11-15H2,(H,27,28)(H,29,30,33)	GBFPBXWTDIPMGT-UHFFFAOYSA-N	479238	US12534452, Example 126	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479238	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479238&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130342223	442138807							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217434	O=C(Nc1nc(CCCCCCN2CCCCC2)cn1-c1ccccc1)c1cccc(-c2cn[nH]c2)c1	InChI=1S/C30H36N6O/c37-29(25-13-11-12-24(20-25)26-21-31-32-22-26)34-30-33-27(23-36(30)28-15-6-3-7-16-28)14-5-1-2-8-17-35-18-9-4-10-19-35/h3,6-7,11-13,15-16,20-23H,1-2,4-5,8-10,14,17-19H2,(H,31,32)(H,33,34,37)	RSMRLZHROSYCBW-UHFFFAOYSA-N	479239	US12534452, Example 127	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479239	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479239&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			141660123	442138808							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217435	O=C(Nc1nc(CCCN2CCOCC2)cn1-c1ccccc1)c1cccc(-c2cn[nH]c2)c1	InChI=1S/C26H28N6O2/c33-25(21-7-4-6-20(16-21)22-17-27-28-18-22)30-26-29-23(8-5-11-31-12-14-34-15-13-31)19-32(26)24-9-2-1-3-10-24/h1-4,6-7,9-10,16-19H,5,8,11-15H2,(H,27,28)(H,29,30,33)	DKKHBMKFUWIVNB-UHFFFAOYSA-N	479240	US12534452, Example 128	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479240	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479240&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130341817	442138809							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217436	CCOC(C)n1cc(-c2cccc(C(=O)Nc3nc(CCCCCCN4CCCCC4)cn3-c3ccccc3)c2)cn1	InChI=1S/C34H44N6O2/c1-3-42-27(2)40-25-30(24-35-40)28-15-14-16-29(23-28)33(41)37-34-36-31(26-39(34)32-18-9-6-10-19-32)17-8-4-5-11-20-38-21-12-7-13-22-38/h6,9-10,14-16,18-19,23-27H,3-5,7-8,11-13,17,20-22H2,1-2H3,(H,36,37,41)	XFXFTRMEWGOPRG-UHFFFAOYSA-N	479241	US12534452, Example 138	Interleukin-1 receptor-associated kinase 4	Homo sapiens		 75							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479241	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479241&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130341547	442138810							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217437	CNC(=O)CCCc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3cnn(C)c3)c2)n1	InChI=1S/C25H26N6O2/c1-26-23(32)13-7-10-21-17-31(22-11-4-3-5-12-22)25(28-21)29-24(33)19-9-6-8-18(14-19)20-15-27-30(2)16-20/h3-6,8-9,11-12,14-17H,7,10,13H2,1-2H3,(H,26,32)(H,28,29,33)	JKFJJGNSICILHR-UHFFFAOYSA-N	479242	US12534452, Example 139	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479242	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479242&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130342074	442138811							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217438	Cn1cc(-c2cccc(C(=O)Nc3nc(CCCC(=O)O)cn3-c3ccccc3)c2)cn1	InChI=1S/C24H23N5O3/c1-28-15-19(14-25-28)17-7-5-8-18(13-17)23(32)27-24-26-20(9-6-12-22(30)31)16-29(24)21-10-3-2-4-11-21/h2-5,7-8,10-11,13-16H,6,9,12H2,1H3,(H,30,31)(H,26,27,32)	ATCGRQWQAKHXKF-UHFFFAOYSA-N	479243	US12534452, Example 140	Interleukin-1 receptor-associated kinase 4	Homo sapiens		 75							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479243	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479243&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			138624088	442138812							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217439	Cn1cc(-c2cccc(C(=O)Nc3nc(CCCC(=O)NC4CC4)cn3-c3ccccc3)c2)cn1	InChI=1S/C27H28N6O2/c1-32-17-21(16-28-32)19-7-5-8-20(15-19)26(35)31-27-30-23(9-6-12-25(34)29-22-13-14-22)18-33(27)24-10-3-2-4-11-24/h2-5,7-8,10-11,15-18,22H,6,9,12-14H2,1H3,(H,29,34)(H,30,31,35)	PXOUKQOOVSLRKF-UHFFFAOYSA-N	479244	US12534452, Example 141	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479244	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479244&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			141660126	442138813							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217440	Cn1cc(-c2cccc(C(=O)Nc3nc(CCCC(=O)N4CCCCC4)cn3-c3ccccc3)c2)cn1	InChI=1S/C29H32N6O2/c1-33-20-24(19-30-33)22-10-8-11-23(18-22)28(37)32-29-31-25(21-35(29)26-13-4-2-5-14-26)12-9-15-27(36)34-16-6-3-7-17-34/h2,4-5,8,10-11,13-14,18-21H,3,6-7,9,12,15-17H2,1H3,(H,31,32,37)	ZKPSQCWZDLBYEK-UHFFFAOYSA-N	479245	US12534452, Example 142	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479245	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479245&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			156027204	442138814							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217441	CN1CCN(C(=O)CCCc2cn(-c3ccccc3)c(NC(=O)c3cccc(-c4cnn(C)c4)c3)n2)CC1	InChI=1S/C29H33N7O2/c1-33-14-16-35(17-15-33)27(37)13-7-10-25-21-36(26-11-4-3-5-12-26)29(31-25)32-28(38)23-9-6-8-22(18-23)24-19-30-34(2)20-24/h3-6,8-9,11-12,18-21H,7,10,13-17H2,1-2H3,(H,31,32,38)	WLVZKCFVLQZIOS-UHFFFAOYSA-N	479246	US12534452, Example 143	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479246	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479246&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130341774	442138815							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217442	CCN1CCN(C(=O)CCCc2cn(-c3ccccc3)c(NC(=O)c3cccc(-c4cnn(C)c4)c3)n2)CC1	InChI=1S/C30H35N7O2/c1-3-35-15-17-36(18-16-35)28(38)14-8-11-26-22-37(27-12-5-4-6-13-27)30(32-26)33-29(39)24-10-7-9-23(19-24)25-20-31-34(2)21-25/h4-7,9-10,12-13,19-22H,3,8,11,14-18H2,1-2H3,(H,32,33,39)	LHFZMQUQMJKRPG-UHFFFAOYSA-N	479247	US12534452, Example 144	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479247	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479247&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130341624	442138816							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217443	CC(C)N1CCN(C(=O)CCCc2cn(-c3ccccc3)c(NC(=O)c3cccc(-c4cnn(C)c4)c3)n2)CC1	InChI=1S/C31H37N7O2/c1-23(2)36-15-17-37(18-16-36)29(39)14-8-11-27-22-38(28-12-5-4-6-13-28)31(33-27)34-30(40)25-10-7-9-24(19-25)26-20-32-35(3)21-26/h4-7,9-10,12-13,19-23H,8,11,14-18H2,1-3H3,(H,33,34,40)	XOWGXLNBNATHMC-UHFFFAOYSA-N	479248	US12534452, Example 145	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479248	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479248&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			138624275	442138817							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217444	CN(C)C1CCN(C(=O)CCCc2cn(-c3ccccc3)c(NC(=O)c3cccc(-c4cnn(C)c4)c3)n2)CC1	InChI=1S/C31H37N7O2/c1-35(2)27-15-17-37(18-16-27)29(39)14-8-11-26-22-38(28-12-5-4-6-13-28)31(33-26)34-30(40)24-10-7-9-23(19-24)25-20-32-36(3)21-25/h4-7,9-10,12-13,19-22,27H,8,11,14-18H2,1-3H3,(H,33,34,40)	WHHJUNRZKDZQHM-UHFFFAOYSA-N	479249	US12534452, Example 146	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479249	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479249&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130341782	442138818							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217445	CN(C)C1CCC(NC(=O)CCCc2cn(-c3ccccc3)c(NC(=O)c3cccc(-c4cnn(C)c4)c3)n2)CC1	InChI=1S/C32H39N7O2/c1-37(2)28-17-15-26(16-18-28)34-30(40)14-8-11-27-22-39(29-12-5-4-6-13-29)32(35-27)36-31(41)24-10-7-9-23(19-24)25-20-33-38(3)21-25/h4-7,9-10,12-13,19-22,26,28H,8,11,14-18H2,1-3H3,(H,34,40)(H,35,36,41)	ZTODFSVYKFUBJX-UHFFFAOYSA-N	479250	US12534452, Example 147	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479250	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479250&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130341769	442138819							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217446	CN1CCC(NC(=O)CCCc2cn(-c3ccccc3)c(NC(=O)c3cccc(-c4cnn(C)c4)c3)n2)CC1	InChI=1S/C30H35N7O2/c1-35-16-14-25(15-17-35)32-28(38)13-7-10-26-21-37(27-11-4-3-5-12-27)30(33-26)34-29(39)23-9-6-8-22(18-23)24-19-31-36(2)20-24/h3-6,8-9,11-12,18-21,25H,7,10,13-17H2,1-2H3,(H,32,38)(H,33,34,39)	VPNQGZHQOUZAAJ-UHFFFAOYSA-N	479251	US12534452, Example 148	Interleukin-1 receptor-associated kinase 4	Homo sapiens		 75							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479251	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479251&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130341533	442138820							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217447	Cn1cc(-c2cccc(C(=O)Nc3nc(CCCC(=O)N4CCN(C5CC5)CC4)cn3-c3ccccc3)c2)cn1	InChI=1S/C31H35N7O2/c1-35-21-25(20-32-35)23-7-5-8-24(19-23)30(40)34-31-33-26(22-38(31)28-10-3-2-4-11-28)9-6-12-29(39)37-17-15-36(16-18-37)27-13-14-27/h2-5,7-8,10-11,19-22,27H,6,9,12-18H2,1H3,(H,33,34,40)	LIPMORSWYFGZRD-UHFFFAOYSA-N	479252	US12534452, Example 149	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479252	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479252&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130341623	442138821							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217448	Cn1cc(-c2cccc(C(=O)Nc3nc(CCCC(=O)Nc4ccncc4)cn3-c3ccccc3)c2)cn1	InChI=1S/C29H27N7O2/c1-35-19-23(18-31-35)21-7-5-8-22(17-21)28(38)34-29-33-25(20-36(29)26-10-3-2-4-11-26)9-6-12-27(37)32-24-13-15-30-16-14-24/h2-5,7-8,10-11,13-20H,6,9,12H2,1H3,(H,30,32,37)(H,33,34,38)	PTUNMLLMTCZDSJ-UHFFFAOYSA-N	479253	US12534452, Example 150	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479253	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479253&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130341534	442138822							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217449	Cn1cc(-c2cccc(C(=O)Nc3nc(CCCC(=O)NN4CCCC4)cn3-c3ccccc3)c2)cn1	InChI=1S/C28H31N7O2/c1-33-19-23(18-29-33)21-9-7-10-22(17-21)27(37)31-28-30-24(20-35(28)25-12-3-2-4-13-25)11-8-14-26(36)32-34-15-5-6-16-34/h2-4,7,9-10,12-13,17-20H,5-6,8,11,14-16H2,1H3,(H,32,36)(H,30,31,37)	WFQVHCFLEOLQSJ-UHFFFAOYSA-N	479254	US12534452, Example 151	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479254	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479254&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130342069	442138823							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217450	Cn1cc(-c2cccc(C(=O)Nc3nc(CCCC(=O)NN4CCCCC4)cn3-c3ccccc3)c2)cn1	InChI=1S/C29H33N7O2/c1-34-20-24(19-30-34)22-10-8-11-23(18-22)28(38)32-29-31-25(21-36(29)26-13-4-2-5-14-26)12-9-15-27(37)33-35-16-6-3-7-17-35/h2,4-5,8,10-11,13-14,18-21H,3,6-7,9,12,15-17H2,1H3,(H,33,37)(H,31,32,38)	FSGJNCNWBCNKCR-UHFFFAOYSA-N	479255	US12534452, Example 152	Interleukin-1 receptor-associated kinase 4	Homo sapiens		 75							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479255	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479255&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130342061	442138824							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217451	CN1CCN(NC(=O)CCCc2cn(-c3ccccc3)c(NC(=O)c3cccc(-c4cnn(C)c4)c3)n2)CC1	InChI=1S/C29H34N8O2/c1-34-14-16-36(17-15-34)33-27(38)13-7-10-25-21-37(26-11-4-3-5-12-26)29(31-25)32-28(39)23-9-6-8-22(18-23)24-19-30-35(2)20-24/h3-6,8-9,11-12,18-21H,7,10,13-17H2,1-2H3,(H,33,38)(H,31,32,39)	WKUSMGRLKCTLKT-UHFFFAOYSA-N	479256	US12534452, Example 153	Interleukin-1 receptor-associated kinase 4	Homo sapiens		 75							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479256	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479256&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			138624124	442138825							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217452	Cn1cc(-c2cccc(C(=O)Nc3nc(CCCC(=O)N4CCC(N5CCCC5)CC4)cn3-c3ccccc3)c2)cn1	InChI=1S/C33H39N7O2/c1-37-23-27(22-34-37)25-9-7-10-26(21-25)32(42)36-33-35-28(24-40(33)30-12-3-2-4-13-30)11-8-14-31(41)39-19-15-29(16-20-39)38-17-5-6-18-38/h2-4,7,9-10,12-13,21-24,29H,5-6,8,11,14-20H2,1H3,(H,35,36,42)	GAWIDECYDDDMGF-UHFFFAOYSA-N	479257	US12534452, Example 154	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479257	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479257&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130341783	442138826							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217453	CN(C)c1ccc(NC(=O)CCCc2cn(-c3ccccc3)c(NC(=O)c3cccc(-c4cnn(C)c4)c3)n2)cc1	InChI=1S/C32H33N7O2/c1-37(2)28-17-15-26(16-18-28)34-30(40)14-8-11-27-22-39(29-12-5-4-6-13-29)32(35-27)36-31(41)24-10-7-9-23(19-24)25-20-33-38(3)21-25/h4-7,9-10,12-13,15-22H,8,11,14H2,1-3H3,(H,34,40)(H,35,36,41)	KDLFFXHNHDZCSM-UHFFFAOYSA-N	479258	US12534452, Example 155	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479258	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479258&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130341768	442138827							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217454	Cn1cc(-c2cccc(C(=O)Nc3nc(CCCC(=O)NC4CCC(O)CC4)cn3-c3ccccc3)c2)cn1	InChI=1S/C30H34N6O3/c1-35-19-23(18-31-35)21-7-5-8-22(17-21)29(39)34-30-33-25(20-36(30)26-10-3-2-4-11-26)9-6-12-28(38)32-24-13-15-27(37)16-14-24/h2-5,7-8,10-11,17-20,24,27,37H,6,9,12-16H2,1H3,(H,32,38)(H,33,34,39)	KUIJTPHTDDQKQO-UHFFFAOYSA-N	479259	US12534452, Example 156	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479259	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479259&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			141660128	442138828							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217455	Cn1cc(-c2cccc(C(=O)Nc3nc(CCCC(=O)NC4CCOCC4)cn3-c3ccccc3)c2)cn1	InChI=1S/C29H32N6O3/c1-34-19-23(18-30-34)21-7-5-8-22(17-21)28(37)33-29-32-25(20-35(29)26-10-3-2-4-11-26)9-6-12-27(36)31-24-13-15-38-16-14-24/h2-5,7-8,10-11,17-20,24H,6,9,12-16H2,1H3,(H,31,36)(H,32,33,37)	ACIUXDWRMLSPSD-UHFFFAOYSA-N	479260	US12534452, Example 157	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479260	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479260&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			138624380	442138829							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217456	Cn1cc(-c2cccc(C(=O)Nc3nc(CCCC(=O)NCCCN4CCCCC4)cn3-c3ccccc3)c2)cn1	InChI=1S/C32H39N7O2/c1-37-23-27(22-34-37)25-11-8-12-26(21-25)31(41)36-32-35-28(24-39(32)29-14-4-2-5-15-29)13-9-16-30(40)33-17-10-20-38-18-6-3-7-19-38/h2,4-5,8,11-12,14-15,21-24H,3,6-7,9-10,13,16-20H2,1H3,(H,33,40)(H,35,36,41)	UPMIGJMTMJDIRQ-UHFFFAOYSA-N	479261	US12534452, Example 158	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479261	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479261&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			141660121	442138830							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217457	Cn1cc(-c2cccc(C(=O)Nc3nc(CCCC(=O)NCCN4CCCCC4)cn3-c3ccccc3)c2)cn1	InChI=1S/C31H37N7O2/c1-36-22-26(21-33-36)24-10-8-11-25(20-24)30(40)35-31-34-27(23-38(31)28-13-4-2-5-14-28)12-9-15-29(39)32-16-19-37-17-6-3-7-18-37/h2,4-5,8,10-11,13-14,20-23H,3,6-7,9,12,15-19H2,1H3,(H,32,39)(H,34,35,40)	RPAMZVBMHUEMFX-UHFFFAOYSA-N	479262	US12534452, Example 159	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479262	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479262&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130341777	442138831							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217458	Cn1cc(-c2cccc(C(=O)Nc3nc(CCCC(=O)N4CCOCC4)cn3-c3ccccc3)c2)cn1	InChI=1S/C28H30N6O3/c1-32-19-23(18-29-32)21-7-5-8-22(17-21)27(36)31-28-30-24(20-34(28)25-10-3-2-4-11-25)9-6-12-26(35)33-13-15-37-16-14-33/h2-5,7-8,10-11,17-20H,6,9,12-16H2,1H3,(H,30,31,36)	KMVOWAFWHDHORE-UHFFFAOYSA-N	479263	US12534452, Example 160	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479263	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479263&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130342152	442138832							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217459	COC1CCC(NC(=O)CCCc2cn(-c3ccccc3)c(NC(=O)c3cccc(-c4cnn(C)c4)c3)n2)CC1	InChI=1S/C31H36N6O3/c1-36-20-24(19-32-36)22-8-6-9-23(18-22)30(39)35-31-34-26(21-37(31)27-11-4-3-5-12-27)10-7-13-29(38)33-25-14-16-28(40-2)17-15-25/h3-6,8-9,11-12,18-21,25,28H,7,10,13-17H2,1-2H3,(H,33,38)(H,34,35,39)	XBCVQJBCXIKIMP-UHFFFAOYSA-N	479264	US12534452, Example 161	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479264	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479264&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130342067	442138833							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217460	CN(C)CCNC(=O)CCCc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3cnn(C)c3)c2)n1	InChI=1S/C28H33N7O2/c1-33(2)16-15-29-26(36)14-8-11-24-20-35(25-12-5-4-6-13-25)28(31-24)32-27(37)22-10-7-9-21(17-22)23-18-30-34(3)19-23/h4-7,9-10,12-13,17-20H,8,11,14-16H2,1-3H3,(H,29,36)(H,31,32,37)	ZTXYUODLUITQIJ-UHFFFAOYSA-N	479265	US12534452, Example 162	Interleukin-1 receptor-associated kinase 4	Homo sapiens		 75							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479265	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479265&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130342041	442138834							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217461	CN(C)CCCNC(=O)CCCc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3cnn(C)c3)c2)n1	InChI=1S/C29H35N7O2/c1-34(2)17-9-16-30-27(37)15-8-12-25-21-36(26-13-5-4-6-14-26)29(32-25)33-28(38)23-11-7-10-22(18-23)24-19-31-35(3)20-24/h4-7,10-11,13-14,18-21H,8-9,12,15-17H2,1-3H3,(H,30,37)(H,32,33,38)	KWRWKKGIDYQZMU-UHFFFAOYSA-N	479266	US12534452, Example 163	Interleukin-1 receptor-associated kinase 4	Homo sapiens		 75							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479266	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479266&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			138624083	442138835							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217462	Cn1cc(-c2cccc(C(=O)Nc3nc(CCCC(=O)NCCO)cn3-c3ccccc3)c2)cn1	InChI=1S/C26H28N6O3/c1-31-17-21(16-28-31)19-7-5-8-20(15-19)25(35)30-26-29-22(9-6-12-24(34)27-13-14-33)18-32(26)23-10-3-2-4-11-23/h2-5,7-8,10-11,15-18,33H,6,9,12-14H2,1H3,(H,27,34)(H,29,30,35)	JWIDCVNZESDDMP-UHFFFAOYSA-N	479267	US12534452, Example 164	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479267	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479267&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130341785	442138836							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217463	Cn1cc(-c2cccc(C(=O)Nc3nc(CCCC(=O)NCCCO)cn3-c3ccccc3)c2)cn1	InChI=1S/C27H30N6O3/c1-32-18-22(17-29-32)20-8-5-9-21(16-20)26(36)31-27-30-23(10-6-13-25(35)28-14-7-15-34)19-33(27)24-11-3-2-4-12-24/h2-5,8-9,11-12,16-19,34H,6-7,10,13-15H2,1H3,(H,28,35)(H,30,31,36)	SMSPVDNCIMEQBV-UHFFFAOYSA-N	479268	US12534452, Example 165	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479268	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479268&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130341800	442138837							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217464	CC1CCCCN1C(=O)CCCc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3cnn(C)c3)c2)n1	InChI=1S/C30H34N6O2/c1-22-10-6-7-17-35(22)28(37)16-9-13-26-21-36(27-14-4-3-5-15-27)30(32-26)33-29(38)24-12-8-11-23(18-24)25-19-31-34(2)20-25/h3-5,8,11-12,14-15,18-22H,6-7,9-10,13,16-17H2,1-2H3,(H,32,33,38)	JIFYPHAFSQXSGX-UHFFFAOYSA-N	479269	US12534452, Example 166	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479269	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479269&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			138624128	442138838							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217465	Cn1cc(-c2cccc(C(=O)Nc3nc(CCCC(=O)N4CCC(C)(C)CC4)cn3-c3ccccc3)c2)cn1	InChI=1S/C31H36N6O2/c1-31(2)15-17-36(18-16-31)28(38)14-8-11-26-22-37(27-12-5-4-6-13-27)30(33-26)34-29(39)24-10-7-9-23(19-24)25-20-32-35(3)21-25/h4-7,9-10,12-13,19-22H,8,11,14-18H2,1-3H3,(H,33,34,39)	MOCJBHUXDCBXIE-UHFFFAOYSA-N	479270	US12534452, Example 167	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479270	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479270&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130342303	442138839							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217466	N#CC1CCN(C(=O)CCCc2cn(-c3ccccc3)c(NC(=O)c3cccc(-c4cnn(C)c4)c3)n2)CC1	InChI=1S/C30H31N7O2/c1-35-20-25(19-32-35)23-7-5-8-24(17-23)29(39)34-30-33-26(21-37(30)27-10-3-2-4-11-27)9-6-12-28(38)36-15-13-22(18-31)14-16-36/h2-5,7-8,10-11,17,19-22H,6,9,12-16H2,1H3,(H,33,34,39)	SVEKRMQMYFKJHT-UHFFFAOYSA-N	479271	US12534452, Example 168	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479271	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479271&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130298640	442138840							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217467	Cn1cc(-c2cccc(C(=O)Nc3nc(CCCC(=O)N4CCC(O)CC4)cn3-c3ccccc3)c2)cn1	InChI=1S/C29H32N6O3/c1-33-19-23(18-30-33)21-7-5-8-22(17-21)28(38)32-29-31-24(20-35(29)25-10-3-2-4-11-25)9-6-12-27(37)34-15-13-26(36)14-16-34/h2-5,7-8,10-11,17-20,26,36H,6,9,12-16H2,1H3,(H,31,32,38)	CRHUMRIAOQIYLT-UHFFFAOYSA-N	479272	US12534452, Example 169	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479272	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479272&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130298644	442138841							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217468	Cn1cc(-c2cccc(C(=O)Nc3nc(CCCC(=O)NCC(C)(C)O)cn3-c3ccccc3)c2)cn1	InChI=1S/C28H32N6O3/c1-28(2,37)19-29-25(35)14-8-11-23-18-34(24-12-5-4-6-13-24)27(31-23)32-26(36)21-10-7-9-20(15-21)22-16-30-33(3)17-22/h4-7,9-10,12-13,15-18,37H,8,11,14,19H2,1-3H3,(H,29,35)(H,31,32,36)	XUGSWOGQCHKDMK-UHFFFAOYSA-N	479273	US12534452, Example 170	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479273	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479273&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130298682	442138842							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217469	Cn1cc(-c2cccc(C(=O)Nc3nc(CCCC(=O)NCCC(C)(C)O)cn3-c3ccccc3)c2)cn1	InChI=1S/C29H34N6O3/c1-29(2,38)15-16-30-26(36)14-8-11-24-20-35(25-12-5-4-6-13-25)28(32-24)33-27(37)22-10-7-9-21(17-22)23-18-31-34(3)19-23/h4-7,9-10,12-13,17-20,38H,8,11,14-16H2,1-3H3,(H,30,36)(H,32,33,37)	MGZLOHUADPRCNF-UHFFFAOYSA-N	479274	US12534452, Example 171	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479274	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479274&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130298610	442138843							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217470	Cn1cc(-c2cccc(C(=O)Nc3nc(CCCC(=O)NCC4CCOCC4)cn3-c3ccccc3)c2)cn1	InChI=1S/C30H34N6O3/c1-35-20-25(19-32-35)23-7-5-8-24(17-23)29(38)34-30-33-26(21-36(30)27-10-3-2-4-11-27)9-6-12-28(37)31-18-22-13-15-39-16-14-22/h2-5,7-8,10-11,17,19-22H,6,9,12-16,18H2,1H3,(H,31,37)(H,33,34,38)	QZLDBNSGXVIKET-UHFFFAOYSA-N	479275	US12534452, Example 172	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479275	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479275&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130298611	442138844							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217471	Cn1cc(-c2cccc(C(=O)Nc3nc(CCCC(=O)N4CCN(Cc5ccc(OC(F)(F)F)cc5)CC4)cn3-c3ccccc3)c2)cn1	InChI=1S/C36H36F3N7O3/c1-43-24-29(22-40-43)27-7-5-8-28(21-27)34(48)42-35-41-30(25-46(35)31-10-3-2-4-11-31)9-6-12-33(47)45-19-17-44(18-20-45)23-26-13-15-32(16-14-26)49-36(37,38)39/h2-5,7-8,10-11,13-16,21-22,24-25H,6,9,12,17-20,23H2,1H3,(H,41,42,48)	JDSPYZLMHBTJNN-UHFFFAOYSA-N	479276	US12534452, Example 173	Interleukin-1 receptor-associated kinase 4	Homo sapiens		 75							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479276	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479276&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130298671	442138845							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217472	Cn1cc(-c2cccc(C(=O)Nc3nc(CCCC(=O)N4CCCC[C@@H]4CCO)cn3-c3ccccc3)c2)cn1	InChI=1S/C31H36N6O3/c1-35-21-25(20-32-35)23-9-7-10-24(19-23)30(40)34-31-33-26(22-37(31)27-12-3-2-4-13-27)11-8-15-29(39)36-17-6-5-14-28(36)16-18-38/h2-4,7,9-10,12-13,19-22,28,38H,5-6,8,11,14-18H2,1H3,(H,33,34,40)	SJPZKORCHUTSAF-UHFFFAOYSA-N	479277	US12534452, Example 174	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479277	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479277&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130298525	442138846							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217473	Cn1cc(-c2cccc(C(=O)Nc3nc(CCCC(=O)N4CCCC(F)(F)C4)cn3-c3ccccc3)c2)cn1	InChI=1S/C29H30F2N6O2/c1-35-18-23(17-32-35)21-8-5-9-22(16-21)27(39)34-28-33-24(19-37(28)25-11-3-2-4-12-25)10-6-13-26(38)36-15-7-14-29(30,31)20-36/h2-5,8-9,11-12,16-19H,6-7,10,13-15,20H2,1H3,(H,33,34,39)	FGUBEYHJAVQJEA-UHFFFAOYSA-N	479278	US12534452, Example 175	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479278	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479278&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130298562	442138847							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217474	Cn1cc(-c2cccc(C(=O)Nc3nc(CCCC(=O)N4CCCC[C@@H]4C(F)(F)F)cn3-c3ccccc3)c2)cn1	InChI=1S/C30H31F3N6O2/c1-37-19-23(18-34-37)21-9-7-10-22(17-21)28(41)36-29-35-24(20-39(29)25-12-3-2-4-13-25)11-8-15-27(40)38-16-6-5-14-26(38)30(31,32)33/h2-4,7,9-10,12-13,17-20,26H,5-6,8,11,14-16H2,1H3,(H,35,36,41)	VTGUTUVOOLFQKN-UHFFFAOYSA-N	479279	US12534452, Example 176	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479279	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479279&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130298540	442138848							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
217475	COC1CCN(C(=O)CCCc2cn(-c3ccccc3)c(NC(=O)c3cccc(-c4cnn(C)c4)c3)n2)CC1	InChI=1S/C30H34N6O3/c1-34-20-24(19-31-34)22-8-6-9-23(18-22)29(38)33-30-32-25(21-36(30)26-11-4-3-5-12-26)10-7-13-28(37)35-16-14-27(39-2)15-17-35/h3-6,8-9,11-12,18-21,27H,7,10,13-17H2,1-2H3,(H,32,33,38)	BZVXPBOPTGSJOA-UHFFFAOYSA-N	479280	US12534452, Example 177	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F			US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479280	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479280&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130298539	442138849							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223244	Cn1cc(-c2cccc(C(=O)Nc3nc(CCCC(=O)N4CCCC(O)C4)cn3-c3ccccc3)c2)cn1	InChI=1S/C29H32N6O3/c1-33-18-23(17-30-33)21-8-5-9-22(16-21)28(38)32-29-31-24(19-35(29)25-11-3-2-4-12-25)10-6-14-27(37)34-15-7-13-26(36)20-34/h2-5,8-9,11-12,16-19,26,36H,6-7,10,13-15,20H2,1H3,(H,31,32,38)	JIKRQMOARLRDFS-UHFFFAOYSA-N	479281	US12534452, Example 178	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479281	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479281&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130298604	442138850							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223245	Cn1cc(-c2cccc(C(=O)Nc3nc(CCCC(=O)NC4CCOC4)cn3-c3ccccc3)c2)cn1	InChI=1S/C28H30N6O3/c1-33-17-22(16-29-33)20-7-5-8-21(15-20)27(36)32-28-31-23(18-34(28)25-10-3-2-4-11-25)9-6-12-26(35)30-24-13-14-37-19-24/h2-5,7-8,10-11,15-18,24H,6,9,12-14,19H2,1H3,(H,30,35)(H,31,32,36)	CDDUANSPSHMBBO-UHFFFAOYSA-N	479282	US12534452, Example 179	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479282	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479282&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130298673	442138851							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223246	Cn1cc(-c2cccc(C(=O)Nc3nc(CCCC(=O)NCC4CCOC4)cn3-c3ccccc3)c2)cn1	InChI=1S/C29H32N6O3/c1-34-18-24(17-31-34)22-7-5-8-23(15-22)28(37)33-29-32-25(19-35(29)26-10-3-2-4-11-26)9-6-12-27(36)30-16-21-13-14-38-20-21/h2-5,7-8,10-11,15,17-19,21H,6,9,12-14,16,20H2,1H3,(H,30,36)(H,32,33,37)	NJMMJJHLENKTOP-UHFFFAOYSA-N	479283	US12534452, Example 180	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479283	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479283&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130298567	442138852							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223247	Cn1cc(-c2cccc(C(=O)Nc3nc(CCCC(=O)N4CCN(C(C)(C)C)CC4)cn3-c3ccccc3)c2)cn1	InChI=1S/C32H39N7O2/c1-32(2,3)38-18-16-37(17-19-38)29(40)15-9-12-27-23-39(28-13-6-5-7-14-28)31(34-27)35-30(41)25-11-8-10-24(20-25)26-21-33-36(4)22-26/h5-8,10-11,13-14,20-23H,9,12,15-19H2,1-4H3,(H,34,35,41)	HDDMWUOJZZGEJQ-UHFFFAOYSA-N	479284	US12534452, Example 181	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479284	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479284&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130298647	442138853							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223248	Cn1cc(-c2cccc(C(=O)Nc3nc(CCCC(=O)N4CCN(C5CCCCC5)CC4)cn3-c3ccccc3)c2)cn1	InChI=1S/C34H41N7O2/c1-38-24-28(23-35-38)26-10-8-11-27(22-26)33(43)37-34-36-29(25-41(34)31-15-6-3-7-16-31)12-9-17-32(42)40-20-18-39(19-21-40)30-13-4-2-5-14-30/h3,6-8,10-11,15-16,22-25,30H,2,4-5,9,12-14,17-21H2,1H3,(H,36,37,43)	UAOPZGCCCATMLJ-UHFFFAOYSA-N	479285	US12534452, Example 182	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479285	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479285&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130298653	442138854							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223249	CN1CCCN(C(=O)CCCc2cn(-c3ccccc3)c(NC(=O)c3cccc(-c4cnn(C)c4)c3)n2)CC1	InChI=1S/C30H35N7O2/c1-34-15-8-16-36(18-17-34)28(38)14-7-11-26-22-37(27-12-4-3-5-13-27)30(32-26)33-29(39)24-10-6-9-23(19-24)25-20-31-35(2)21-25/h3-6,9-10,12-13,19-22H,7-8,11,14-18H2,1-2H3,(H,32,33,39)	SOLOCLPWLBLMCB-UHFFFAOYSA-N	479286	US12534452, Example 183	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479286	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479286&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130298597	442138855							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223250	Cn1cc(-c2cccc(C(=O)Nc3nc(CCCC(=O)NCCN4CCOCC4)cn3-c3ccccc3)c2)cn1	InChI=1S/C30H35N7O3/c1-35-21-25(20-32-35)23-7-5-8-24(19-23)29(39)34-30-33-26(22-37(30)27-10-3-2-4-11-27)9-6-12-28(38)31-13-14-36-15-17-40-18-16-36/h2-5,7-8,10-11,19-22H,6,9,12-18H2,1H3,(H,31,38)(H,33,34,39)	UYDLDMCFTGYCJI-UHFFFAOYSA-N	479287	US12534452, Example 184	Interleukin-1 receptor-associated kinase 4	Homo sapiens		>100							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479287	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479287&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130341922	442138856							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223251	Cn1cc(-c2cccc(C(=O)Nc3nc(CCCC(=O)NC[C@@H](F)C(C)(C)O)cn3-c3ccccc3)c2)cn1	InChI=1S/C29H33FN6O3/c1-29(2,39)25(30)17-31-26(37)14-8-11-23-19-36(24-12-5-4-6-13-24)28(33-23)34-27(38)21-10-7-9-20(15-21)22-16-32-35(3)18-22/h4-7,9-10,12-13,15-16,18-19,25,39H,8,11,14,17H2,1-3H3,(H,31,37)(H,33,34,38)	MUOCBXDUBQZKHJ-UHFFFAOYSA-N	479288	US12534452, Example 185	Interleukin-1 receptor-associated kinase 4	Homo sapiens		 75							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479288	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479288&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130341863	442138857							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223252	CN1CCN(CCCNC(=O)CCCc2cn(-c3ccccc3)c(NC(=O)c3cccc(-c4cnn(C)c4)c3)n2)CC1	InChI=1S/C32H40N8O2/c1-37-17-19-39(20-18-37)16-8-15-33-30(41)14-7-11-28-24-40(29-12-4-3-5-13-29)32(35-28)36-31(42)26-10-6-9-25(21-26)27-22-34-38(2)23-27/h3-6,9-10,12-13,21-24H,7-8,11,14-20H2,1-2H3,(H,33,41)(H,35,36,42)	AHQCIOWJCMWDKJ-UHFFFAOYSA-N	479289	US12534452, Example 186	Interleukin-1 receptor-associated kinase 4	Homo sapiens		 75							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479289	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479289&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130298623	442138858							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223253	CN1CCN(CCNC(=O)CCCc2cn(-c3ccccc3)c(NC(=O)c3cccc(-c4cnn(C)c4)c3)n2)CC1	InChI=1S/C31H38N8O2/c1-36-16-18-38(19-17-36)15-14-32-29(40)13-7-10-27-23-39(28-11-4-3-5-12-28)31(34-27)35-30(41)25-9-6-8-24(20-25)26-21-33-37(2)22-26/h3-6,8-9,11-12,20-23H,7,10,13-19H2,1-2H3,(H,32,40)(H,34,35,41)	VBEKEGAHQAMNCG-UHFFFAOYSA-N	479290	US12534452, Example 187	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479290	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479290&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130298550	442138859							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223254	Cn1cc(-c2cccc(C(=O)Nc3nc(CCCC(=O)N4CCN(c5ccccc5)CC4)cn3-c3ccccc3)c2)cn1	InChI=1S/C34H35N7O2/c1-38-24-28(23-35-38)26-10-8-11-27(22-26)33(43)37-34-36-29(25-41(34)31-15-6-3-7-16-31)12-9-17-32(42)40-20-18-39(19-21-40)30-13-4-2-5-14-30/h2-8,10-11,13-16,22-25H,9,12,17-21H2,1H3,(H,36,37,43)	UIADTXANSYGRKM-UHFFFAOYSA-N	479291	US12534452, Example 188	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479291	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479291&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130341859	442138860							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223255	Cn1cc(-c2cccc(C(=O)Nc3nc(CCCC(N)=O)cn3-c3ccccc3)c2)cn1	InChI=1S/C24H24N6O2/c1-29-15-19(14-26-29)17-7-5-8-18(13-17)23(32)28-24-27-20(9-6-12-22(25)31)16-30(24)21-10-3-2-4-11-21/h2-5,7-8,10-11,13-16H,6,9,12H2,1H3,(H2,25,31)(H,27,28,32)	APHURVRTHPRNLJ-UHFFFAOYSA-N	479292	US12534452, Example 189	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479292	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479292&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130298549	442138861							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223256	Cn1cc(-c2cccc(C(=O)Nc3nc(CCCC(=O)Nc4ccn(C)n4)cn3-c3ccccc3)c2)cn1	InChI=1S/C28H28N8O2/c1-34-15-14-25(33-34)31-26(37)13-7-10-23-19-36(24-11-4-3-5-12-24)28(30-23)32-27(38)21-9-6-8-20(16-21)22-17-29-35(2)18-22/h3-6,8-9,11-12,14-19H,7,10,13H2,1-2H3,(H,30,32,38)(H,31,33,37)	HOGKHXYROJCMDC-UHFFFAOYSA-N	479293	US12534452, Example 190	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479293	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479293&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130298518	442138862							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223257	Cn1cc(-c2cccc(C(=O)Nc3nc(CCCC(=O)Nc4ccc5c(cnn5C)c4)cn3-c3ccccc3)c2)cn1	InChI=1S/C32H30N8O2/c1-38-20-25(19-33-38)22-8-6-9-23(16-22)31(42)37-32-36-27(21-40(32)28-11-4-3-5-12-28)10-7-13-30(41)35-26-14-15-29-24(17-26)18-34-39(29)2/h3-6,8-9,11-12,14-21H,7,10,13H2,1-2H3,(H,35,41)(H,36,37,42)	JRCBWVPZDSPPSU-UHFFFAOYSA-N	479294	US12534452, Example 191	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479294	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479294&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130298672	442138863							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223258	Cn1cc(-c2cccc(C(=O)Nc3nc(CCC(=O)Nc4ccccc4)cn3-c3ccccc3)c2)cn1	InChI=1S/C29H26N6O2/c1-34-19-23(18-30-34)21-9-8-10-22(17-21)28(37)33-29-32-25(20-35(29)26-13-6-3-7-14-26)15-16-27(36)31-24-11-4-2-5-12-24/h2-14,17-20H,15-16H2,1H3,(H,31,36)(H,32,33,37)	PXCJAMKSEWWZFG-UHFFFAOYSA-N	479295	US12534452, Example 193	Interleukin-1 receptor-associated kinase 4	Homo sapiens		 75							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479295	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479295&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130298568	442138864							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223259	CN1CCN(C(=O)CCc2cn(-c3ccccc3)c(NC(=O)c3cccc(-c4cnn(C)c4)c3)n2)CC1	InChI=1S/C28H31N7O2/c1-32-13-15-34(16-14-32)26(36)12-11-24-20-35(25-9-4-3-5-10-25)28(30-24)31-27(37)22-8-6-7-21(17-22)23-18-29-33(2)19-23/h3-10,17-20H,11-16H2,1-2H3,(H,30,31,37)	QLCWYZMBDKKQNS-UHFFFAOYSA-N	479296	US12534452, Example 194	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479296	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479296&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130342121	442138865							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223260	CN1CCCN(C(=O)CCc2cn(-c3ccccc3)c(NC(=O)c3cccc(-c4cnn(C)c4)c3)n2)CC1	InChI=1S/C29H33N7O2/c1-33-14-7-15-35(17-16-33)27(37)13-12-25-21-36(26-10-4-3-5-11-26)29(31-25)32-28(38)23-9-6-8-22(18-23)24-19-30-34(2)20-24/h3-6,8-11,18-21H,7,12-17H2,1-2H3,(H,31,32,38)	QBDUSMHLAZQYJA-UHFFFAOYSA-N	479297	US12534452, Example 195	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479297	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479297&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130298534	442138866							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223261	CN1CCCN(C(=O)CCc2cn(-c3ccccc3)c(NC(=O)c3cccc(-c4cnn(C)c4)c3)n2)CC1	InChI=1S/C29H33N7O2/c1-33-14-7-15-35(17-16-33)27(37)13-12-25-21-36(26-10-4-3-5-11-26)29(31-25)32-28(38)23-9-6-8-22(18-23)24-19-30-34(2)20-24/h3-6,8-11,18-21H,7,12-17H2,1-2H3,(H,31,32,38)	QBDUSMHLAZQYJA-UHFFFAOYSA-N	479297	US12534452, Example 195	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479297	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479297&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130298534	442138866							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223262	Cn1cc(-c2cccc(C(=O)Nc3nc(CCCCC(=O)NC4CCOCC4)cn3-c3ccccc3)c2)cn1	InChI=1S/C30H34N6O3/c1-35-20-24(19-31-35)22-8-7-9-23(18-22)29(38)34-30-33-26(21-36(30)27-11-3-2-4-12-27)10-5-6-13-28(37)32-25-14-16-39-17-15-25/h2-4,7-9,11-12,18-21,25H,5-6,10,13-17H2,1H3,(H,32,37)(H,33,34,38)	TVBWPOGZXNIDGX-UHFFFAOYSA-N	479298	US12534452, Example 197	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479298	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479298&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130342119	442138867							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223263	Cn1cc(-c2cccc(C(=O)Nc3nc(CCCCC(=O)NCCN4CCOCC4)cn3-c3ccccc3)c2)cn1	InChI=1S/C31H37N7O3/c1-36-22-26(21-33-36)24-8-7-9-25(20-24)30(40)35-31-34-27(23-38(31)28-11-3-2-4-12-28)10-5-6-13-29(39)32-14-15-37-16-18-41-19-17-37/h2-4,7-9,11-12,20-23H,5-6,10,13-19H2,1H3,(H,32,39)(H,34,35,40)	YVHQELZXAKAFRB-UHFFFAOYSA-N	479299	US12534452, Example 198	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479299	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479299&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130342117	442138868							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223264	Cn1cc(-c2cccc(C(=O)Nc3nc(CCCCCC(=O)NC4CC4)cn3-c3ccccc3)c2)cn1	InChI=1S/C29H32N6O2/c1-34-19-23(18-30-34)21-9-8-10-22(17-21)28(37)33-29-32-25(20-35(29)26-12-5-3-6-13-26)11-4-2-7-14-27(36)31-24-15-16-24/h3,5-6,8-10,12-13,17-20,24H,2,4,7,11,14-16H2,1H3,(H,31,36)(H,32,33,37)	UNDSGIIPEFNNEX-UHFFFAOYSA-N	479300	US12534452, Example 199	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479300	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479300&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130342122	442138869							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223265	Cn1cc(-c2cccc(C(=O)Nc3nc(CCCCCC(=O)N4CCCCC4)cn3-c3ccccc3)c2)cn1	InChI=1S/C31H36N6O2/c1-35-22-26(21-32-35)24-12-11-13-25(20-24)30(39)34-31-33-27(23-37(31)28-15-6-3-7-16-28)14-5-2-8-17-29(38)36-18-9-4-10-19-36/h3,6-7,11-13,15-16,20-23H,2,4-5,8-10,14,17-19H2,1H3,(H,33,34,39)	QQQSBDRONUGAAZ-UHFFFAOYSA-N	479301	US12534452, Example 200	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479301	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479301&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130342123	442138870							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223266	CN1CCN(C(=O)CCCCCc2cn(-c3ccccc3)c(NC(=O)c3cccc(-c4cnn(C)c4)c3)n2)CC1	InChI=1S/C31H37N7O2/c1-35-16-18-37(19-17-35)29(39)15-8-3-5-12-27-23-38(28-13-6-4-7-14-28)31(33-27)34-30(40)25-11-9-10-24(20-25)26-21-32-36(2)22-26/h4,6-7,9-11,13-14,20-23H,3,5,8,12,15-19H2,1-2H3,(H,33,34,40)	KCKPYOHXBDXLGS-UHFFFAOYSA-N	479302	US12534452, Example 201	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479302	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479302&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130342124	442138871							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223267	Cn1cc(-c2cccc(C(=O)Nc3nc(CCCC(=O)N4CCNCC4)cn3-c3ccccc3)c2)cn1	InChI=1S/C28H31N7O2/c1-33-19-23(18-30-33)21-7-5-8-22(17-21)27(37)32-28-31-24(20-35(28)25-10-3-2-4-11-25)9-6-12-26(36)34-15-13-29-14-16-34/h2-5,7-8,10-11,17-20,29H,6,9,12-16H2,1H3,(H,31,32,37)	IJUHHQFKCKLODN-UHFFFAOYSA-N	479303	US12534452, Example 202	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479303	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479303&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130342120	442138872							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223268	Cn1cc(-c2cccc(C(=O)Nc3nc(CCC(=O)N4CCNCC4)cn3-c3ccccc3)c2)cn1	InChI=1S/C27H29N7O2/c1-32-18-22(17-29-32)20-6-5-7-21(16-20)26(36)31-27-30-23(19-34(27)24-8-3-2-4-9-24)10-11-25(35)33-14-12-28-13-15-33/h2-9,16-19,28H,10-15H2,1H3,(H,30,31,36)	NMCBYQFUVMODOB-UHFFFAOYSA-N	479304	US12534452, Example 203	Interleukin-1 receptor-associated kinase 4	Homo sapiens		 75							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479304	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479304&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			138624422	442138873							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223269	Cn1cc(-c2cccc(C(=O)Nc3nc(CCCCC(=O)N4CCNCC4)cn3-c3ccccc3)c2)cn1	InChI=1S/C29H33N7O2/c1-34-20-24(19-31-34)22-8-7-9-23(18-22)28(38)33-29-32-25(21-36(29)26-11-3-2-4-12-26)10-5-6-13-27(37)35-16-14-30-15-17-35/h2-4,7-9,11-12,18-21,30H,5-6,10,13-17H2,1H3,(H,32,33,38)	NMIINQBXIPYJGK-UHFFFAOYSA-N	479305	US12534452, Example 204	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479305	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479305&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130298553	442138874							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223270	CC(=O)N1CCN(C(=O)CCCc2cn(-c3ccccc3)c(NC(=O)c3cccc(-c4cnn(C)c4)c3)n2)CC1	InChI=1S/C30H33N7O3/c1-22(38)35-14-16-36(17-15-35)28(39)13-7-10-26-21-37(27-11-4-3-5-12-27)30(32-26)33-29(40)24-9-6-8-23(18-24)25-19-31-34(2)20-25/h3-6,8-9,11-12,18-21H,7,10,13-17H2,1-2H3,(H,32,33,40)	HJNDWOCDVTVTJJ-UHFFFAOYSA-N	479306	US12534452, Example 205	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479306	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479306&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130342403	442138875							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223271	Cn1cc(-c2cccc(C(=O)Nc3nc(CCCC(=O)N4CCN(S(C)(=O)=O)CC4)cn3-c3ccccc3)c2)cn1	InChI=1S/C29H33N7O4S/c1-33-20-24(19-30-33)22-8-6-9-23(18-22)28(38)32-29-31-25(21-36(29)26-11-4-3-5-12-26)10-7-13-27(37)34-14-16-35(17-15-34)41(2,39)40/h3-6,8-9,11-12,18-21H,7,10,13-17H2,1-2H3,(H,31,32,38)	HZQJBTFTWLBYJZ-UHFFFAOYSA-N	479307	US12534452, Example 206	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479307	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479307&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130342262	442138876							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223272	Cn1cc(-c2cccc(C(=O)Nc3nc(CCCC(=O)N4CCC[C@H](C(=O)O)C4)cn3-c3ccccc3)c2)cn1	InChI=1S/C30H32N6O4/c1-34-18-24(17-31-34)21-8-5-9-22(16-21)28(38)33-30-32-25(20-36(30)26-12-3-2-4-13-26)11-6-14-27(37)35-15-7-10-23(19-35)29(39)40/h2-5,8-9,12-13,16-18,20,23H,6-7,10-11,14-15,19H2,1H3,(H,39,40)(H,32,33,38)	SSPFGNGHAUPBOW-UHFFFAOYSA-N	479308	US12534452, Example 207	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=479308	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=479308&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			130298556	442138877							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223273	Cn1cc(-c2cccc(C(=O)Nc3nc(CCCCC(=O)N4CCCC(C(=O)O)C4)cn3-c3ccccc3)c2)cn1	InChI=1S/C31H34N6O4/c1-35-19-25(18-32-35)22-9-7-10-23(17-22)29(39)34-31-33-26(21-37(31)27-13-3-2-4-14-27)12-5-6-15-28(38)36-16-8-11-24(20-36)30(40)41/h2-4,7,9-10,13-14,17-19,21,24H,5-6,8,11-12,15-16,20H2,1H3,(H,40,41)(H,33,34,39)	VKPUKVNQADELBY-UHFFFAOYSA-N	506623	US12534452, Example 208	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506623	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506623&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			146318487	459091766							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223274	Cn1cc(-c2cccc(C(=O)Nc3nc(CCCC(=O)N4CCC(N)CC4)cn3-c3ccccc3)c2)cn1	InChI=1S/C29H33N7O2/c1-34-19-23(18-31-34)21-7-5-8-22(17-21)28(38)33-29-32-25(20-36(29)26-10-3-2-4-11-26)9-6-12-27(37)35-15-13-24(30)14-16-35/h2-5,7-8,10-11,17-20,24H,6,9,12-16,30H2,1H3,(H,32,33,38)	FIYIYLLQCXUGPJ-UHFFFAOYSA-N	506624	US12534452, Example 209	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506624	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506624&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			146318415	459091767							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223275	Cn1cc(-c2cccc(C(=O)Nc3nc(CCCC(=O)N4CCC[C@@H](N)C4)cn3-c3ccccc3)c2)cn1	InChI=1S/C29H33N7O2/c1-34-18-23(17-31-34)21-8-5-9-22(16-21)28(38)33-29-32-25(20-36(29)26-12-3-2-4-13-26)11-6-14-27(37)35-15-7-10-24(30)19-35/h2-5,8-9,12-13,16-18,20,24H,6-7,10-11,14-15,19,30H2,1H3,(H,32,33,38)	BLANHMTXHSIKAM-UHFFFAOYSA-N	506625	US12534452, Example 210	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506625	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506625&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			146318426	459091768							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223276	Cn1cc(-c2cccc(C(=O)Nc3nc(CCCC(=O)N4CCC[C@H](N)C4)cn3-c3ccccc3)c2)cn1	InChI=1S/C29H33N7O2/c1-34-18-23(17-31-34)21-8-5-9-22(16-21)28(38)33-29-32-25(20-36(29)26-12-3-2-4-13-26)11-6-14-27(37)35-15-7-10-24(30)19-35/h2-5,8-9,12-13,16-18,20,24H,6-7,10-11,14-15,19,30H2,1H3,(H,32,33,38)	BLANHMTXHSIKAM-UHFFFAOYSA-N	506626	US12534452, Example 211	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506626	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506626&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			146318335	459091769							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223277	Cn1cc(-c2cccc(C(=O)Nc3nc(CCCC(=O)N4CC[C@@H](N)C4)cn3-c3ccccc3)c2)cn1	InChI=1S/C28H31N7O2/c1-33-17-22(16-30-33)20-7-5-8-21(15-20)27(37)32-28-31-24(19-35(28)25-10-3-2-4-11-25)9-6-12-26(36)34-14-13-23(29)18-34/h2-5,7-8,10-11,15-17,19,23H,6,9,12-14,18,29H2,1H3,(H,31,32,37)	HKOCXHXJVOZDJE-UHFFFAOYSA-N	506628	US12534452, Example 212	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506628	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506628&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			146318467	459091771							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223278	Cn1cc(-c2cccc(C(=O)Nc3nc(CCCCC(=O)N4CCC(N)CC4)cn3-c3ccccc3)c2)cn1	InChI=1S/C30H35N7O2/c1-35-20-24(19-32-35)22-8-7-9-23(18-22)29(39)34-30-33-26(21-37(30)27-11-3-2-4-12-27)10-5-6-13-28(38)36-16-14-25(31)15-17-36/h2-4,7-9,11-12,18-21,25H,5-6,10,13-17,31H2,1H3,(H,33,34,39)	ZQLFSPMPAZVPKG-UHFFFAOYSA-N	506629	US12534452, Example 213	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506629	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506629&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			146318339	459091772							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223279	Cn1cc(-c2cccc(C(=O)Nc3nc(CCCC(=O)NC4CCNCC4)cn3-c3ccccc3)c2)cn1	InChI=1S/C29H33N7O2/c1-35-19-23(18-31-35)21-7-5-8-22(17-21)28(38)34-29-33-25(20-36(29)26-10-3-2-4-11-26)9-6-12-27(37)32-24-13-15-30-16-14-24/h2-5,7-8,10-11,17-20,24,30H,6,9,12-16H2,1H3,(H,32,37)(H,33,34,38)	QPSKZONBYOFFNO-UHFFFAOYSA-N	506630	US12534452, Example 214	Interleukin-1 receptor-associated kinase 4	Homo sapiens		>100							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506630	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506630&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			146318341	459091773							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223280	Cn1cc(-c2cccc(C(=O)Nc3nc(CCCC(=O)N[C@H]4CC[C@H](N)CC4)cn3-c3ccccc3)c2)cn1	InChI=1S/C30H35N7O2/c1-36-19-23(18-32-36)21-7-5-8-22(17-21)29(39)35-30-34-26(20-37(30)27-10-3-2-4-11-27)9-6-12-28(38)33-25-15-13-24(31)14-16-25/h2-5,7-8,10-11,17-20,24-25H,6,9,12-16,31H2,1H3,(H,33,38)(H,34,35,39)	XZBZEKBMFBEGPY-UHFFFAOYSA-N	506631	US12534452, Example 215	Interleukin-1 receptor-associated kinase 4	Homo sapiens		 75							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506631	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506631&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			153315553	459091774							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223281	Cn1cc(-c2cccc(C(=O)Nc3nc(CCCC(=O)Nc4cc[nH]n4)cn3-c3ccccc3)c2)cn1	InChI=1S/C27H26N8O2/c1-34-17-21(16-29-34)19-7-5-8-20(15-19)26(37)32-27-30-22(18-35(27)23-10-3-2-4-11-23)9-6-12-25(36)31-24-13-14-28-33-24/h2-5,7-8,10-11,13-18H,6,9,12H2,1H3,(H,30,32,37)(H2,28,31,33,36)	WBDJPFBDERCUQY-UHFFFAOYSA-N	506632	US12534452, Example 217	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506632	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506632&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			146318436	459091775							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223282	CN1CCN(N(C)C(=O)CCCc2cn(-c3ccccc3)c(NC(=O)c3cccc(-c4cnn(C)c4)c3)n2)CC1	InChI=1S/C30H36N8O2/c1-34-15-17-37(18-16-34)36(3)28(39)14-8-11-26-22-38(27-12-5-4-6-13-27)30(32-26)33-29(40)24-10-7-9-23(19-24)25-20-31-35(2)21-25/h4-7,9-10,12-13,19-22H,8,11,14-18H2,1-3H3,(H,32,33,40)	GYLNRQFDVMGTNF-UHFFFAOYSA-N	506633	US12534452, Example 218	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506633	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506633&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			153315605	459091776							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223283	Cn1cc(-c2cccc(C(=O)Nc3nc(CCCCN4CCCCC4)cn3-c3ccccc3)c2)cn1	InChI=1S/C29H34N6O/c1-33-21-25(20-30-33)23-11-10-12-24(19-23)28(36)32-29-31-26(22-35(29)27-14-4-2-5-15-27)13-6-9-18-34-16-7-3-8-17-34/h2,4-5,10-12,14-15,19-22H,3,6-9,13,16-18H2,1H3,(H,31,32,36)	GLNFIQMRDYDWLF-UHFFFAOYSA-N	506634	US12534452, Example 219	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506634	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506634&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			146318346	459091777							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223284	Cn1cc(-c2cccc(C(=O)Nc3nc(CCCCCCN4CCCCC4)cn3-c3ccccc3)c2)cn1	InChI=1S/C31H38N6O/c1-35-23-27(22-32-35)25-13-12-14-26(21-25)30(38)34-31-33-28(24-37(31)29-16-7-4-8-17-29)15-6-2-3-9-18-36-19-10-5-11-20-36/h4,7-8,12-14,16-17,21-24H,2-3,5-6,9-11,15,18-20H2,1H3,(H,33,34,38)	SCFXZZXZOHFROE-UHFFFAOYSA-N	506635	US12534452, Example 220	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506635	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506635&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			146318489	459091778							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223285	CN1CCN(CCCCc2cn(-c3ccccc3)c(NC(=O)c3cccc(-c4cnn(C)c4)c3)n2)CC1	InChI=1S/C29H35N7O/c1-33-15-17-35(18-16-33)14-7-6-11-26-22-36(27-12-4-3-5-13-27)29(31-26)32-28(37)24-10-8-9-23(19-24)25-20-30-34(2)21-25/h3-5,8-10,12-13,19-22H,6-7,11,14-18H2,1-2H3,(H,31,32,37)	FCMUVMYNZUUERJ-UHFFFAOYSA-N	506636	US12534452, Example 221	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506636	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506636&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			146318522	459091779							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223286	Cn1cc(-c2cccc(C(=O)Nc3nc(CCCCCCN4CCCC4)cn3-c3ccccc3)c2)cn1	InChI=1S/C30H36N6O/c1-34-22-26(21-31-34)24-12-11-13-25(20-24)29(37)33-30-32-27(23-36(30)28-15-6-4-7-16-28)14-5-2-3-8-17-35-18-9-10-19-35/h4,6-7,11-13,15-16,20-23H,2-3,5,8-10,14,17-19H2,1H3,(H,32,33,37)	IJTHUORDHGEPLN-UHFFFAOYSA-N	506638	US12534452, Example 222	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506638	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506638&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			146318475	459091781							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223287	Cn1cc(-c2cccc(C(=O)Nc3nc(CCCCCCN4CCCCCC4)cn3-c3ccccc3)c2)cn1	InChI=1S/C32H40N6O/c1-36-24-28(23-33-36)26-14-13-15-27(22-26)31(39)35-32-34-29(25-38(32)30-17-8-6-9-18-30)16-7-2-3-10-19-37-20-11-4-5-12-21-37/h6,8-9,13-15,17-18,22-25H,2-5,7,10-12,16,19-21H2,1H3,(H,34,35,39)	NJCPSPLWZYIYNQ-UHFFFAOYSA-N	506639	US12534452, Example 223	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506639	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506639&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			146318476	459091782							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223288	Cn1cc(-c2cccc(C(=O)Nc3nc(CCCCN4CCCC4=O)cn3-c3ccccc3)c2)cn1	InChI=1S/C28H30N6O2/c1-32-19-23(18-29-32)21-9-7-10-22(17-21)27(36)31-28-30-24(20-34(28)25-12-3-2-4-13-25)11-5-6-15-33-16-8-14-26(33)35/h2-4,7,9-10,12-13,17-20H,5-6,8,11,14-16H2,1H3,(H,30,31,36)	ONCMPVWEUMXJES-UHFFFAOYSA-N	506640	US12534452, Example 224	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506640	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506640&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			146318477	459091783							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223289	Cn1cc(-c2cccc(C(=O)Nc3nc(CCCCCCN4CCCC4=O)cn3-c3ccccc3)c2)cn1	InChI=1S/C30H34N6O2/c1-34-21-25(20-31-34)23-11-9-12-24(19-23)29(38)33-30-32-26(22-36(30)27-14-6-4-7-15-27)13-5-2-3-8-17-35-18-10-16-28(35)37/h4,6-7,9,11-12,14-15,19-22H,2-3,5,8,10,13,16-18H2,1H3,(H,32,33,38)	BQYVFPXANWEEIV-UHFFFAOYSA-N	506641	US12534452, Example 225	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506641	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506641&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			146318347	459091784							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223290	Cn1cc(-c2cccc(C(=O)Nc3nc(CCCCCCN4C(=O)CCC4=O)cn3-c3ccccc3)c2)cn1	InChI=1S/C30H32N6O3/c1-34-20-24(19-31-34)22-10-9-11-23(18-22)29(39)33-30-32-25(21-36(30)26-13-6-4-7-14-26)12-5-2-3-8-17-35-27(37)15-16-28(35)38/h4,6-7,9-11,13-14,18-21H,2-3,5,8,12,15-17H2,1H3,(H,32,33,39)	CNANWMFLVYYSDT-UHFFFAOYSA-N	506642	US12534452, Example 226	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506642	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506642&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			146318348	459091785							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223291	Cn1cc(-c2cccc(C(=O)Nc3nc(CCCCNC(=O)C4CC4)cn3-c3ccccc3)c2)cn1	InChI=1S/C28H30N6O2/c1-33-18-23(17-30-33)21-8-7-9-22(16-21)27(36)32-28-31-24(19-34(28)25-11-3-2-4-12-25)10-5-6-15-29-26(35)20-13-14-20/h2-4,7-9,11-12,16-20H,5-6,10,13-15H2,1H3,(H,29,35)(H,31,32,36)	KRLUFKARYNDVLZ-UHFFFAOYSA-N	506643	US12534452, Example 227	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506643	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506643&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			146318472	459091786							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223292	Cn1cc(-c2cccc(C(=O)Nc3nc(CCCCCCNC(=O)C4CC4)cn3-c3ccccc3)c2)cn1	InChI=1S/C30H34N6O2/c1-35-20-25(19-32-35)23-10-9-11-24(18-23)29(38)34-30-33-26(21-36(30)27-13-6-4-7-14-27)12-5-2-3-8-17-31-28(37)22-15-16-22/h4,6-7,9-11,13-14,18-22H,2-3,5,8,12,15-17H2,1H3,(H,31,37)(H,33,34,38)	VAYPFPGIFSKJJI-UHFFFAOYSA-N	506644	US12534452, Example 228	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506644	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506644&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			146318351	459091787							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223293	O=C(CCCc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3cn[nH]c3F)c2)n1)NC1CC1	InChI=1S/C26H25FN6O2/c27-24-22(15-28-32-24)17-6-4-7-18(14-17)25(35)31-26-30-20(8-5-11-23(34)29-19-12-13-19)16-33(26)21-9-2-1-3-10-21/h1-4,6-7,9-10,14-16,19H,5,8,11-13H2,(H,28,32)(H,29,34)(H,30,31,35)	FYDNKYJHAVATHT-UHFFFAOYSA-N	506645	US12534452, Example 229	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506645	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506645&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			148661670	459091788							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223294	CN1CCN(C(=O)CCCc2cn(-c3ccccc3)c(NC(=O)c3cccc(-c4cn[nH]c4F)c3)n2)CC1	InChI=1S/C28H30FN7O2/c1-34-13-15-35(16-14-34)25(37)12-6-9-22-19-36(23-10-3-2-4-11-23)28(31-22)32-27(38)21-8-5-7-20(17-21)24-18-30-33-26(24)29/h2-5,7-8,10-11,17-19H,6,9,12-16H2,1H3,(H,30,33)(H,31,32,38)	FWSIEEFERGMLJY-UHFFFAOYSA-N	506646	US12534452, Example 230	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506646	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506646&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			146318361	459091789							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223295	O=C(Nc1nc(CCCC(=O)N2CCCCC2)cn1-c1ccccc1)c1cccc(-c2cn[nH]c2F)c1	InChI=1S/C28H29FN6O2/c29-26-24(18-30-33-26)20-9-7-10-21(17-20)27(37)32-28-31-22(19-35(28)23-12-3-1-4-13-23)11-8-14-25(36)34-15-5-2-6-16-34/h1,3-4,7,9-10,12-13,17-19H,2,5-6,8,11,14-16H2,(H,30,33)(H,31,32,37)	KAFLQDYCITXMHX-UHFFFAOYSA-N	506647	US12534452, Example 231	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506647	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506647&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			146318537	459091790							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223296	Cn1ncc(-c2cccc(C(=O)Nc3nc(CCCC(=O)NC4CC4)cn3-c3ccccc3)c2)c1F	InChI=1S/C27H27FN6O2/c1-33-25(28)23(16-29-33)18-7-5-8-19(15-18)26(36)32-27-31-21(9-6-12-24(35)30-20-13-14-20)17-34(27)22-10-3-2-4-11-22/h2-5,7-8,10-11,15-17,20H,6,9,12-14H2,1H3,(H,30,35)(H,31,32,36)	LKJUYHUUVOMMJF-UHFFFAOYSA-N	506648	US12534452, Example 232	Interleukin-1 receptor-associated kinase 4	Homo sapiens		 75							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506648	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506648&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			153315569	459091791							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223297	CN(C(=O)CCCc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3cnn(C)c3F)c2)n1)C1CC1	InChI=1S/C28H29FN6O2/c1-33(22-14-15-22)25(36)13-7-10-21-18-35(23-11-4-3-5-12-23)28(31-21)32-27(37)20-9-6-8-19(16-20)24-17-30-34(2)26(24)29/h3-6,8-9,11-12,16-18,22H,7,10,13-15H2,1-2H3,(H,31,32,37)	YRNUHQZGGHKFCT-UHFFFAOYSA-N	506649	US12534452, Example 233	Interleukin-1 receptor-associated kinase 4	Homo sapiens		 75							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506649	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506649&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			146318353	459091792							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223298	O=C(CCCc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3cnn(CF)c3)c2)n1)NC1CC1	InChI=1S/C27H27FN6O2/c28-18-33-16-21(15-29-33)19-6-4-7-20(14-19)26(36)32-27-31-23(8-5-11-25(35)30-22-12-13-22)17-34(27)24-9-2-1-3-10-24/h1-4,6-7,9-10,14-17,22H,5,8,11-13,18H2,(H,30,35)(H,31,32,36)	HYBOGKJIVDRRFH-UHFFFAOYSA-N	506650	US12534452, Example 234	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506650	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506650&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			146318352	459091793							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223299	O=C(CCCc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3cnn(C(F)F)c3)c2)n1)NC1CC1	InChI=1S/C27H26F2N6O2/c28-26(29)35-16-20(15-30-35)18-6-4-7-19(14-18)25(37)33-27-32-22(8-5-11-24(36)31-21-12-13-21)17-34(27)23-9-2-1-3-10-23/h1-4,6-7,9-10,14-17,21,26H,5,8,11-13H2,(H,31,36)(H,32,33,37)	PHLIJTXRCDCJBA-UHFFFAOYSA-N	506651	US12534452, Example 235	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506651	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506651&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			146318492	459091794							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223300	O=C(CCCc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3cnn(C(F)(F)F)c3)c2)n1)NC1CC1	InChI=1S/C27H25F3N6O2/c28-27(29,30)36-16-20(15-31-36)18-6-4-7-19(14-18)25(38)34-26-33-22(8-5-11-24(37)32-21-12-13-21)17-35(26)23-9-2-1-3-10-23/h1-4,6-7,9-10,14-17,21H,5,8,11-13H2,(H,32,37)(H,33,34,38)	VPSQLJYHYDWBMW-UHFFFAOYSA-N	506652	US12534452, Example 236	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506652	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506652&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			146318494	459091795							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223301	O=C(Nc1nc(CCCCCC(=O)N2CCCCC2)cn1-c1ccccc1)c1cccc(-c2ccc3[nH]ncc3c2)c1	InChI=1S/C34H36N6O2/c41-32(39-19-8-3-9-20-39)16-7-1-4-13-29-24-40(30-14-5-2-6-15-30)34(36-29)37-33(42)27-12-10-11-25(21-27)26-17-18-31-28(22-26)23-35-38-31/h2,5-6,10-12,14-15,17-18,21-24H,1,3-4,7-9,13,16,19-20H2,(H,35,38)(H,36,37,42)	NHCVECQZZVADGJ-UHFFFAOYSA-N	506653	US12534452, Example 237	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506653	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506653&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			153315582	459091796							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223302	O=C(CCCCCc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3ccc4[nH]ncc4c3)c2)n1)NC1CC1	InChI=1S/C32H32N6O2/c39-30(34-26-15-16-26)13-6-1-3-10-27-21-38(28-11-4-2-5-12-28)32(35-27)36-31(40)24-9-7-8-22(18-24)23-14-17-29-25(19-23)20-33-37-29/h2,4-5,7-9,11-12,14,17-21,26H,1,3,6,10,13,15-16H2,(H,33,37)(H,34,39)(H,35,36,40)	PTDVYUVGXVLVQO-UHFFFAOYSA-N	506654	US12534452, Example 238	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506654	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506654&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			146318493	459091797							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223303	CN1CCN(C(=O)CCCCCc2cn(-c3ccccc3)c(NC(=O)c3cccc(-c4ccc5[nH]ncc5c4)c3)n2)CC1	InChI=1S/C34H37N7O2/c1-39-17-19-40(20-18-39)32(42)14-7-2-4-11-29-24-41(30-12-5-3-6-13-30)34(36-29)37-33(43)27-10-8-9-25(21-27)26-15-16-31-28(22-26)23-35-38-31/h3,5-6,8-10,12-13,15-16,21-24H,2,4,7,11,14,17-20H2,1H3,(H,35,38)(H,36,37,43)	PGGMMCPHLOLWPI-UHFFFAOYSA-N	506655	US12534452, Example 239	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506655	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506655&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			146318542	459091798							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223304	O=C(Nc1nc(CCCCCC(=O)N2CCCC2)cn1-c1ccccc1)c1cccc(-c2ccc3[nH]ncc3c2)c1	InChI=1S/C33H34N6O2/c40-31(38-18-7-8-19-38)15-6-1-3-12-28-23-39(29-13-4-2-5-14-29)33(35-28)36-32(41)26-11-9-10-24(20-26)25-16-17-30-27(21-25)22-34-37-30/h2,4-5,9-11,13-14,16-17,20-23H,1,3,6-8,12,15,18-19H2,(H,34,37)(H,35,36,41)	KSEYVBHJBQBMNL-UHFFFAOYSA-N	506656	US12534452, Example 240	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506656	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506656&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			146318495	459091799							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223305	O=C(Nc1nc(CCCCCC(=O)N2CCCCCC2)cn1-c1ccccc1)c1cccc(-c2ccc3[nH]ncc3c2)c1	InChI=1S/C35H38N6O2/c42-33(40-20-9-1-2-10-21-40)17-8-3-5-14-30-25-41(31-15-6-4-7-16-31)35(37-30)38-34(43)28-13-11-12-26(22-28)27-18-19-32-29(23-27)24-36-39-32/h4,6-7,11-13,15-16,18-19,22-25H,1-3,5,8-10,14,17,20-21H2,(H,36,39)(H,37,38,43)	RCDGJFNTEABZRY-UHFFFAOYSA-N	506657	US12534452, Example 241	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506657	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506657&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			146318378	459091800							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223306	O=C(Nc1nc(CCCCCC(=O)N2CCCCC2)cn1-c1ccccc1)c1cccc(-c2ccc3[nH]nnc3c2)c1	InChI=1S/C33H35N7O2/c41-31(39-19-8-3-9-20-39)16-7-1-4-13-27-23-40(28-14-5-2-6-15-28)33(34-27)35-32(42)26-12-10-11-24(21-26)25-17-18-29-30(22-25)37-38-36-29/h2,5-6,10-12,14-15,17-18,21-23H,1,3-4,7-9,13,16,19-20H2,(H,34,35,42)(H,36,37,38)	NPMXYBZRBRAYFY-UHFFFAOYSA-N	506658	US12534452, Example 242	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506658	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506658&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			146318389	459091801							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223307	CNC(=O)Cc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3ccc4[nH]ncc4c3)c2)n1	InChI=1S/C26H22N6O2/c1-27-24(33)14-21-16-32(22-8-3-2-4-9-22)26(29-21)30-25(34)19-7-5-6-17(12-19)18-10-11-23-20(13-18)15-28-31-23/h2-13,15-16H,14H2,1H3,(H,27,33)(H,28,31)(H,29,30,34)	PVBQKMLCOGMVAE-UHFFFAOYSA-N	506660	US12534452, Example 243	Interleukin-1 receptor-associated kinase 4	Homo sapiens		 75							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506660	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506660&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			146318382	459091803							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223308	CNC(=O)CCCc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3ccc4[nH]ncc4c3)c2)n1	InChI=1S/C28H26N6O2/c1-29-26(35)12-6-9-23-18-34(24-10-3-2-4-11-24)28(31-23)32-27(36)21-8-5-7-19(15-21)20-13-14-25-22(16-20)17-30-33-25/h2-5,7-8,10-11,13-18H,6,9,12H2,1H3,(H,29,35)(H,30,33)(H,31,32,36)	CMPIVOXDKBZVNK-UHFFFAOYSA-N	506661	US12534452, Example 244	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506661	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506661&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			146318383	459091804							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223309	O=C(CCCc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3ccc4[nH]ncc4c3)c2)n1)NC1CC1	InChI=1S/C30H28N6O2/c37-28(32-24-13-14-24)11-5-8-25-19-36(26-9-2-1-3-10-26)30(33-25)34-29(38)22-7-4-6-20(16-22)21-12-15-27-23(17-21)18-31-35-27/h1-4,6-7,9-10,12,15-19,24H,5,8,11,13-14H2,(H,31,35)(H,32,37)(H,33,34,38)	KUPXNIUMAGIQFR-UHFFFAOYSA-N	506662	US12534452, Example 245	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506662	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506662&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			153315606	459091805							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223310	O=C(Nc1nc(CCCC(=O)N2CCCCC2)cn1-c1ccccc1)c1cccc(-c2ccc3[nH]ncc3c2)c1	InChI=1S/C32H32N6O2/c39-30(37-17-5-2-6-18-37)14-8-11-27-22-38(28-12-3-1-4-13-28)32(34-27)35-31(40)25-10-7-9-23(19-25)24-15-16-29-26(20-24)21-33-36-29/h1,3-4,7,9-10,12-13,15-16,19-22H,2,5-6,8,11,14,17-18H2,(H,33,36)(H,34,35,40)	LGWWAPRADJNODV-UHFFFAOYSA-N	506663	US12534452, Example 246	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506663	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506663&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			146318386	459091806							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223311	CN1CCN(C(=O)CCCc2cn(-c3ccccc3)c(NC(=O)c3cccc(-c4ccc5[nH]ncc5c4)c3)n2)CC1	InChI=1S/C32H33N7O2/c1-37-15-17-38(18-16-37)30(40)12-6-9-27-22-39(28-10-3-2-4-11-28)32(34-27)35-31(41)25-8-5-7-23(19-25)24-13-14-29-26(20-24)21-33-36-29/h2-5,7-8,10-11,13-14,19-22H,6,9,12,15-18H2,1H3,(H,33,36)(H,34,35,41)	HLRUEVWTWPHNCA-UHFFFAOYSA-N	506664	US12534452, Example 247	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506664	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506664&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			146318384	459091807							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223312	O=C(CCCc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3cccc4cn[nH]c34)c2)n1)NC1CC1	InChI=1S/C30H28N6O2/c37-27(32-23-15-16-23)14-6-10-24-19-36(25-11-2-1-3-12-25)30(33-24)34-29(38)21-8-4-7-20(17-21)26-13-5-9-22-18-31-35-28(22)26/h1-5,7-9,11-13,17-19,23H,6,10,14-16H2,(H,31,35)(H,32,37)(H,33,34,38)	OAVVINDAUGLICA-UHFFFAOYSA-N	506665	US12534452, Example 248	Interleukin-1 receptor-associated kinase 4	Homo sapiens		>100							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506665	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506665&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			146318380	459091808							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223313	O=C(CCCc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3cccc4[nH]ncc34)c2)n1)NC1CC1	InChI=1S/C30H28N6O2/c37-28(32-22-15-16-22)14-5-9-23-19-36(24-10-2-1-3-11-24)30(33-23)34-29(38)21-8-4-7-20(17-21)25-12-6-13-27-26(25)18-31-35-27/h1-4,6-8,10-13,17-19,22H,5,9,14-16H2,(H,31,35)(H,32,37)(H,33,34,38)	OHRHDDPXSLAQSI-UHFFFAOYSA-N	506666	US12534452, Example 249	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506666	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506666&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			146318381	459091809							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223314	O=C(CCCc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3ccc4cn[nH]c4c3)c2)n1)NC1CC1	InChI=1S/C30H28N6O2/c37-28(32-24-14-15-24)11-5-8-25-19-36(26-9-2-1-3-10-26)30(33-25)34-29(38)22-7-4-6-20(16-22)21-12-13-23-18-31-35-27(23)17-21/h1-4,6-7,9-10,12-13,16-19,24H,5,8,11,14-15H2,(H,31,35)(H,32,37)(H,33,34,38)	BTYXRFZULUOXRK-UHFFFAOYSA-N	506667	US12534452, Example 250	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506667	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506667&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			146318390	459091810							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223315	Cn1ncc2cc(-c3cccc(C(=O)Nc4nc(CCCCCC(=O)N5CCCCC5)cn4-c4ccccc4)c3)ccc21	InChI=1S/C35H38N6O2/c1-39-32-19-18-27(23-29(32)24-36-39)26-12-11-13-28(22-26)34(43)38-35-37-30(25-41(35)31-15-6-3-7-16-31)14-5-2-8-17-33(42)40-20-9-4-10-21-40/h3,6-7,11-13,15-16,18-19,22-25H,2,4-5,8-10,14,17,20-21H2,1H3,(H,37,38,43)	XYEZQVKLATVBAB-UHFFFAOYSA-N	506668	US12534452, Example 251	Interleukin-1 receptor-associated kinase 4	Homo sapiens		>100							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506668	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506668&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			146318385	459091811							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223316	O=C(Nc1nc(CCCCCCN2CCCCC2)cn1-c1ccccc1)c1cccc(-c2ccc3[nH]ncc3c2)c1	InChI=1S/C34H38N6O/c41-33(28-13-11-12-26(22-28)27-17-18-32-29(23-27)24-35-38-32)37-34-36-30(25-40(34)31-15-6-3-7-16-31)14-5-1-2-8-19-39-20-9-4-10-21-39/h3,6-7,11-13,15-18,22-25H,1-2,4-5,8-10,14,19-21H2,(H,35,38)(H,36,37,41)	AWEPNONDHBDFHM-UHFFFAOYSA-N	506669	US12534452, Example 252	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506669	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506669&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			156541874	459091812							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223317	O=C(Nc1nc(CCCCCCN2CCCCC2)cn1-c1ccccc1)c1cccc(-c2ccc3[nH]ccc3c2)c1	InChI=1S/C35H39N5O/c41-34(30-13-11-12-27(25-30)28-17-18-33-29(24-28)19-20-36-33)38-35-37-31(26-40(35)32-15-6-3-7-16-32)14-5-1-2-8-21-39-22-9-4-10-23-39/h3,6-7,11-13,15-20,24-26,36H,1-2,4-5,8-10,14,21-23H2,(H,37,38,41)	XPQDWFPLQJQPGG-UHFFFAOYSA-N	506670	US12534452, Example 253	Interleukin-1 receptor-associated kinase 4	Homo sapiens		 75							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506670	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506670&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			146318387	459091813							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223318	O=C(Nc1nc(CCCCCCN2CCOCC2)cn1-c1ccccc1)c1cccc(-c2ccc3[nH]ncc3c2)c1	InChI=1S/C33H36N6O2/c40-32(27-10-8-9-25(21-27)26-14-15-31-28(22-26)23-34-37-31)36-33-35-29(24-39(33)30-12-5-3-6-13-30)11-4-1-2-7-16-38-17-19-41-20-18-38/h3,5-6,8-10,12-15,21-24H,1-2,4,7,11,16-20H2,(H,34,37)(H,35,36,40)	RAXXWIBINXTFQP-UHFFFAOYSA-N	506671	US12534452, Example 254	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506671	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506671&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			148419289	459091814							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223319	O=C(Nc1nc(CCCCCCN2CCCCC2)cn1-c1ccccc1)c1cccc(-c2cccc3[nH]ncc23)c1	InChI=1S/C34H38N6O/c41-33(27-14-11-13-26(23-27)30-18-12-19-32-31(30)24-35-38-32)37-34-36-28(25-40(34)29-16-6-3-7-17-29)15-5-1-2-8-20-39-21-9-4-10-22-39/h3,6-7,11-14,16-19,23-25H,1-2,4-5,8-10,15,20-22H2,(H,35,38)(H,36,37,41)	HCJLAVDUHUEGTL-UHFFFAOYSA-N	506672	US12534452, Example 255	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506672	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506672&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			146318524	459091815							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223320	O=C(Nc1nc(CCCCN2CCCCC2)cn1-c1ccccc1)c1cccc(-c2ccc3[nH]ncc3c2)c1	InChI=1S/C32H34N6O/c39-31(26-11-9-10-24(20-26)25-15-16-30-27(21-25)22-33-36-30)35-32-34-28(23-38(32)29-13-3-1-4-14-29)12-5-8-19-37-17-6-2-7-18-37/h1,3-4,9-11,13-16,20-23H,2,5-8,12,17-19H2,(H,33,36)(H,34,35,39)	IAUBRPXRPHSQQC-UHFFFAOYSA-N	506673	US12534452, Example 256	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506673	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506673&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			146318525	459091816							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223321	O=C(Nc1nc(CCCCN2CCCCC2)cn1-c1ccccc1)c1cccc(-c2cccc3[nH]ncc23)c1	InChI=1S/C32H34N6O/c39-31(25-12-9-11-24(21-25)28-16-10-17-30-29(28)22-33-36-30)35-32-34-26(23-38(32)27-14-3-1-4-15-27)13-5-8-20-37-18-6-2-7-19-37/h1,3-4,9-12,14-17,21-23H,2,5-8,13,18-20H2,(H,33,36)(H,34,35,39)	RNWPKJIXCPJOJD-UHFFFAOYSA-N	506674	US12534452, Example 257	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506674	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506674&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			146318527	459091817							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223322	O=C(Nc1nc(CCCCN2CCCC2=O)cn1-c1ccccc1)c1cccc(-c2ccc3[nH]ncc3c2)c1	InChI=1S/C31H30N6O2/c38-29-13-7-17-36(29)16-5-4-10-26-21-37(27-11-2-1-3-12-27)31(33-26)34-30(39)24-9-6-8-22(18-24)23-14-15-28-25(19-23)20-32-35-28/h1-3,6,8-9,11-12,14-15,18-21H,4-5,7,10,13,16-17H2,(H,32,35)(H,33,34,39)	SRAYEWOZXWCDLD-UHFFFAOYSA-N	506675	US12534452, Example 258	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506675	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506675&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			146318388	459091818							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223323	O=C(Nc1nc(CCCCCCN2CCCC2=O)cn1-c1ccccc1)c1cccc(-c2ccc3[nH]ncc3c2)c1	InChI=1S/C33H34N6O2/c40-31-15-9-19-38(31)18-7-2-1-4-12-28-23-39(29-13-5-3-6-14-29)33(35-28)36-32(41)26-11-8-10-24(20-26)25-16-17-30-27(21-25)22-34-37-30/h3,5-6,8,10-11,13-14,16-17,20-23H,1-2,4,7,9,12,15,18-19H2,(H,34,37)(H,35,36,41)	XDJOQRVCQRWLOF-UHFFFAOYSA-N	506676	US12534452, Example 259	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506676	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506676&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			146318354	459091819							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223324	O=C(Nc1nc(CCCCCCN2CCCCC2=O)cn1-c1ccccc1)c1cccc(-c2ccc3[nH]ncc3c2)c1	InChI=1S/C34H36N6O2/c41-32-16-7-9-20-39(32)19-8-2-1-4-13-29-24-40(30-14-5-3-6-15-30)34(36-29)37-33(42)27-12-10-11-25(21-27)26-17-18-31-28(22-26)23-35-38-31/h3,5-6,10-12,14-15,17-18,21-24H,1-2,4,7-9,13,16,19-20H2,(H,35,38)(H,36,37,42)	FIPLYDKOHVADSA-UHFFFAOYSA-N	506677	US12534452, Example 260	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506677	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506677&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			146318369	459091820							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223325	O=C(Nc1nc(CCCCNC(=O)C2CC2)cn1-c1ccccc1)c1cccc(-c2ccc3[nH]ncc3c2)c1	InChI=1S/C31H30N6O2/c38-29(21-12-13-21)32-16-5-4-9-26-20-37(27-10-2-1-3-11-27)31(34-26)35-30(39)24-8-6-7-22(17-24)23-14-15-28-25(18-23)19-33-36-28/h1-3,6-8,10-11,14-15,17-21H,4-5,9,12-13,16H2,(H,32,38)(H,33,36)(H,34,35,39)	OFAOORIHRVYMEU-UHFFFAOYSA-N	506678	US12534452, Example 261	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506678	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506678&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			146318370	459091821							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223326	O=C(Nc1nc(CCCCCCNC(=O)C2CC2)cn1-c1ccccc1)c1cccc(-c2ccc3[nH]ncc3c2)c1	InChI=1S/C33H34N6O2/c40-31(23-14-15-23)34-18-7-2-1-4-11-28-22-39(29-12-5-3-6-13-29)33(36-28)37-32(41)26-10-8-9-24(19-26)25-16-17-30-27(20-25)21-35-38-30/h3,5-6,8-10,12-13,16-17,19-23H,1-2,4,7,11,14-15,18H2,(H,34,40)(H,35,38)(H,36,37,41)	HAFBHWJVPRQWEN-UHFFFAOYSA-N	506679	US12534452, Example 262	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506679	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506679&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			146318355	459091822							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223327	Cn1ncc2cc(-c3cccc(C(=O)Nc4nc(CCCCCCN5CCCCC5)cn4-c4ccccc4)c3)ccc21	InChI=1S/C35H40N6O/c1-39-33-19-18-28(24-30(33)25-36-39)27-13-12-14-29(23-27)34(42)38-35-37-31(26-41(35)32-16-7-4-8-17-32)15-6-2-3-9-20-40-21-10-5-11-22-40/h4,7-8,12-14,16-19,23-26H,2-3,5-6,9-11,15,20-22H2,1H3,(H,37,38,42)	BNBIARGECSIYCC-UHFFFAOYSA-N	506680	US12534452, Example 263	Interleukin-1 receptor-associated kinase 4	Homo sapiens		 75							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506680	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506680&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			153315604	459091823							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223328	Cn1ncc2cc(-c3cccc(C(=O)Nc4nc(CCCCCCN5CCOCC5)cn4-c4ccccc4)c3)ccc21	InChI=1S/C34H38N6O2/c1-38-32-16-15-27(23-29(32)24-35-38)26-10-9-11-28(22-26)33(41)37-34-36-30(25-40(34)31-13-6-4-7-14-31)12-5-2-3-8-17-39-18-20-42-21-19-39/h4,6-7,9-11,13-16,22-25H,2-3,5,8,12,17-21H2,1H3,(H,36,37,41)	FHOIUMFUHWJWHI-UHFFFAOYSA-N	506681	US12534452, Example 264	Interleukin-1 receptor-associated kinase 4	Homo sapiens		>100							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506681	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506681&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			146318419	459091824							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223329	CNC(=O)Cc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3ccncc3)c2)n1	InChI=1S/C24H21N5O2/c1-25-22(30)15-20-16-29(21-8-3-2-4-9-21)24(27-20)28-23(31)19-7-5-6-18(14-19)17-10-12-26-13-11-17/h2-14,16H,15H2,1H3,(H,25,30)(H,27,28,31)	DPXCHFFAXREOSL-UHFFFAOYSA-N	506682	US12534452, Example 265	Interleukin-1 receptor-associated kinase 4	Homo sapiens		>100							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506682	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506682&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			146318420	459091825							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223330	CNC(=O)CCCc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3ccncc3)c2)n1	InChI=1S/C26H25N5O2/c1-27-24(32)12-6-9-22-18-31(23-10-3-2-4-11-23)26(29-22)30-25(33)21-8-5-7-20(17-21)19-13-15-28-16-14-19/h2-5,7-8,10-11,13-18H,6,9,12H2,1H3,(H,27,32)(H,29,30,33)	LNDZWERTKDRGEA-UHFFFAOYSA-N	506683	US12534452, Example 266	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506683	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506683&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			146318424	459091826							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223331	O=C(CCCc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3ccncc3)c2)n1)NC1CC1	InChI=1S/C28H27N5O2/c34-26(30-23-12-13-23)11-5-8-24-19-33(25-9-2-1-3-10-25)28(31-24)32-27(35)22-7-4-6-21(18-22)20-14-16-29-17-15-20/h1-4,6-7,9-10,14-19,23H,5,8,11-13H2,(H,30,34)(H,31,32,35)	OJVOEDHIWPSZAA-UHFFFAOYSA-N	506684	US12534452, Example 267	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506684	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506684&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			146318430	459091827							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223332	O=C(Nc1nc(CCCCCCN2CCCCC2)cn1-c1ccccc1)c1cccc(-c2ccncc2)c1	InChI=1S/C32H37N5O/c38-31(28-13-11-12-27(24-28)26-17-19-33-20-18-26)35-32-34-29(25-37(32)30-15-6-3-7-16-30)14-5-1-2-8-21-36-22-9-4-10-23-36/h3,6-7,11-13,15-20,24-25H,1-2,4-5,8-10,14,21-23H2,(H,34,35,38)	SDJCXKAXHBAOHK-UHFFFAOYSA-N	506685	US12534452, Example 268	Interleukin-1 receptor-associated kinase 4	Homo sapiens		 75							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506685	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506685&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			146318421	459091828							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223333	O=C(Nc1nc(CCCCCCN2CCCCC2)cn1-c1ccccc1)c1cccc(-c2ccccn2)c1	InChI=1S/C32H37N5O/c38-31(27-15-13-14-26(24-27)30-19-8-9-20-33-30)35-32-34-28(25-37(32)29-17-6-3-7-18-29)16-5-1-2-10-21-36-22-11-4-12-23-36/h3,6-9,13-15,17-20,24-25H,1-2,4-5,10-12,16,21-23H2,(H,34,35,38)	UDASOHFBLGXXBK-UHFFFAOYSA-N	506686	US12534452, Example 269	Interleukin-1 receptor-associated kinase 4	Homo sapiens		>100							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506686	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506686&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			156514299	459091829							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223334	O=C(Nc1nc(CCCCCCN2CCCCC2)cn1-c1ccccc1)c1cccc(-c2cccnc2)c1	InChI=1S/C32H37N5O/c38-31(27-14-11-13-26(23-27)28-15-12-19-33-24-28)35-32-34-29(25-37(32)30-17-6-3-7-18-30)16-5-1-2-8-20-36-21-9-4-10-22-36/h3,6-7,11-15,17-19,23-25H,1-2,4-5,8-10,16,20-22H2,(H,34,35,38)	QSNKLLOHOJXDOT-UHFFFAOYSA-N	506687	US12534452, Example 270	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506687	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506687&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			146318529	459091830							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223335	Nc1ccc(-c2cccc(C(=O)Nc3nc(CCCCCC(=O)N4CCCCC4)cn3-c3ccccc3)c2)cn1	InChI=1S/C32H36N6O2/c33-29-18-17-26(22-34-29)24-11-10-12-25(21-24)31(40)36-32-35-27(23-38(32)28-14-5-2-6-15-28)13-4-1-7-16-30(39)37-19-8-3-9-20-37/h2,5-6,10-12,14-15,17-18,21-23H,1,3-4,7-9,13,16,19-20H2,(H2,33,34)(H,35,36,40)	PQGOBRWVYUQPDO-UHFFFAOYSA-N	506688	US12534452, Example 271	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506688	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506688&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			146318528	459091831							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223336	CN1CCN(C(=O)CCCCCc2cn(-c3ccccc3)c(NC(=O)c3cccc(-c4ccc(N)nc4)c3)n2)CC1	InChI=1S/C32H37N7O2/c1-37-17-19-38(20-18-37)30(40)14-7-2-4-11-27-23-39(28-12-5-3-6-13-28)32(35-27)36-31(41)25-10-8-9-24(21-25)26-15-16-29(33)34-22-26/h3,5-6,8-10,12-13,15-16,21-23H,2,4,7,11,14,17-20H2,1H3,(H2,33,34)(H,35,36,41)	WJYIBRPQAUXCED-UHFFFAOYSA-N	506689	US12534452, Example 272	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506689	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506689&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			146318543	459091832							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223337	Nc1ccc(-c2cccc(C(=O)Nc3nc(CCCC(=O)N4CCCCC4)cn3-c3ccccc3)c2)cn1	InChI=1S/C30H32N6O2/c31-27-16-15-24(20-32-27)22-9-7-10-23(19-22)29(38)34-30-33-25(21-36(30)26-12-3-1-4-13-26)11-8-14-28(37)35-17-5-2-6-18-35/h1,3-4,7,9-10,12-13,15-16,19-21H,2,5-6,8,11,14,17-18H2,(H2,31,32)(H,33,34,38)	VOSABJZBYNEJHF-UHFFFAOYSA-N	506690	US12534452, Example 273	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506690	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506690&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			146318536	459091833							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223338	CN1CCN(C(=O)CCCc2cn(-c3ccccc3)c(NC(=O)c3cccc(-c4ccc(N)nc4)c3)n2)CC1	InChI=1S/C30H33N7O2/c1-35-15-17-36(18-16-35)28(38)12-6-9-25-21-37(26-10-3-2-4-11-26)30(33-25)34-29(39)23-8-5-7-22(19-23)24-13-14-27(31)32-20-24/h2-5,7-8,10-11,13-14,19-21H,6,9,12,15-18H2,1H3,(H2,31,32)(H,33,34,39)	YKHULQKITKMPGZ-UHFFFAOYSA-N	506691	US12534452, Example 274	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506691	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506691&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			153315578	459091834							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223339	Nc1ccc(-c2cccc(C(=O)Nc3nc(CCCCCCN4CCCCC4)cn3-c3ccccc3)c2)cn1	InChI=1S/C32H38N6O/c33-30-18-17-27(23-34-30)25-12-11-13-26(22-25)31(39)36-32-35-28(24-38(32)29-15-6-3-7-16-29)14-5-1-2-8-19-37-20-9-4-10-21-37/h3,6-7,11-13,15-18,22-24H,1-2,4-5,8-10,14,19-21H2,(H2,33,34)(H,35,36,39)	LLGXOCVENFCYGP-UHFFFAOYSA-N	506692	US12534452, Example 275	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506692	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506692&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			146318440	459091835							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223340	Nc1ccc(-c2cccc(C(=O)Nc3nc(CCCCCCN4CCCC4=O)cn3-c3ccccc3)c2)cn1	InChI=1S/C31H34N6O2/c32-28-17-16-25(21-33-28)23-10-8-11-24(20-23)30(39)35-31-34-26(22-37(31)27-13-5-3-6-14-27)12-4-1-2-7-18-36-19-9-15-29(36)38/h3,5-6,8,10-11,13-14,16-17,20-22H,1-2,4,7,9,12,15,18-19H2,(H2,32,33)(H,34,35,39)	HDSIQRFLXGRZBW-UHFFFAOYSA-N	506693	US12534452, Example 276	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506693	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506693&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			146318443	459091836							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223341	Nc1ccc(-c2cccc(C(=O)Nc3nc(CCCCN4CCCC4=O)cn3-c3ccccc3)c2)cn1	InChI=1S/C29H30N6O2/c30-26-15-14-23(19-31-26)21-8-6-9-22(18-21)28(37)33-29-32-24(20-35(29)25-11-2-1-3-12-25)10-4-5-16-34-17-7-13-27(34)36/h1-3,6,8-9,11-12,14-15,18-20H,4-5,7,10,13,16-17H2,(H2,30,31)(H,32,33,37)	GQVOFOFZICPNHH-UHFFFAOYSA-N	506694	US12534452, Example 277	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506694	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506694&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			146318444	459091837							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223342	Nc1ccc(-c2cccc(C(=O)Nc3nc(CCCCCCNC(=O)C4CC4)cn3-c3ccccc3)c2)cn1	InChI=1S/C31H34N6O2/c32-28-17-16-25(20-34-28)23-9-8-10-24(19-23)30(39)36-31-35-26(21-37(31)27-12-5-3-6-13-27)11-4-1-2-7-18-33-29(38)22-14-15-22/h3,5-6,8-10,12-13,16-17,19-22H,1-2,4,7,11,14-15,18H2,(H2,32,34)(H,33,38)(H,35,36,39)	DMEGLQVMRUFORW-UHFFFAOYSA-N	506695	US12534452, Example 278	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506695	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506695&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			146318441	459091838							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223343	O=C(CCCc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3ccc4ncsc4c3)c2)n1)NC1CC1	InChI=1S/C30H27N5O2S/c36-28(32-23-13-14-23)11-5-8-24-18-35(25-9-2-1-3-10-25)30(33-24)34-29(37)22-7-4-6-20(16-22)21-12-15-26-27(17-21)38-19-31-26/h1-4,6-7,9-10,12,15-19,23H,5,8,11,13-14H2,(H,32,36)(H,33,34,37)	ZIDGLZSLZOIOOD-UHFFFAOYSA-N	506696	US12534452, Example 279	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506696	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506696&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			146318501	459091839							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223344	CN1CCN(C(=O)CCCc2cn(-c3ccccc3)c(NC(=O)c3cccc(-c4ccc5ncsc5c4)c3)n2)CC1	InChI=1S/C32H32N6O2S/c1-36-15-17-37(18-16-36)30(39)12-6-9-26-21-38(27-10-3-2-4-11-27)32(34-26)35-31(40)25-8-5-7-23(19-25)24-13-14-28-29(20-24)41-22-33-28/h2-5,7-8,10-11,13-14,19-22H,6,9,12,15-18H2,1H3,(H,34,35,40)	OESKMVNXSKNYQV-UHFFFAOYSA-N	506697	US12534452, Example 280	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506697	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506697&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			146318497	459091840							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223345	CN(C)C1CCN(C(=O)CCCc2cn(-c3ccccc3)c(NC(=O)c3cccc(-c4ccc5ncsc5c4)c3)n2)CC1	InChI=1S/C34H36N6O2S/c1-38(2)28-16-18-39(19-17-28)32(41)13-7-10-27-22-40(29-11-4-3-5-12-29)34(36-27)37-33(42)26-9-6-8-24(20-26)25-14-15-30-31(21-25)43-23-35-30/h3-6,8-9,11-12,14-15,20-23,28H,7,10,13,16-19H2,1-2H3,(H,36,37,42)	SFQDJHDTWVJEQR-UHFFFAOYSA-N	506698	US12534452, Example 281	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506698	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506698&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			146318499	459091841							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223346	CN(C)C1CCN(C(=O)CCCc2cn(-c3ccccc3)c(NC(=O)c3cccc(-c4ccc5scnc5c4)c3)n2)CC1	InChI=1S/C34H36N6O2S/c1-38(2)28-16-18-39(19-17-28)32(41)13-7-10-27-22-40(29-11-4-3-5-12-29)34(36-27)37-33(42)26-9-6-8-24(20-26)25-14-15-31-30(21-25)35-23-43-31/h3-6,8-9,11-12,14-15,20-23,28H,7,10,13,16-19H2,1-2H3,(H,36,37,42)	XILPYFAJIQIOBB-UHFFFAOYSA-N	506699	US12534452, Example 282	Interleukin-1 receptor-associated kinase 4	Homo sapiens		>100							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506699	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506699&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			146318496	459091842							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223347	O=C(CCCc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3ccc4scnc4c3)c2)n1)NC1CC1	InChI=1S/C30H27N5O2S/c36-28(32-23-13-14-23)11-5-8-24-18-35(25-9-2-1-3-10-25)30(33-24)34-29(37)22-7-4-6-20(16-22)21-12-15-27-26(17-21)31-19-38-27/h1-4,6-7,9-10,12,15-19,23H,5,8,11,13-14H2,(H,32,36)(H,33,34,37)	UYIDVRCTNFAXIZ-UHFFFAOYSA-N	506700	US12534452, Example 283	Interleukin-1 receptor-associated kinase 4	Homo sapiens		>100							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506700	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506700&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			146318500	459091843							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223348	CN1CCN(C(=O)CCCc2cn(-c3ccccc3)c(NC(=O)c3cccc(-c4ccc5scnc5c4)c3)n2)CC1	InChI=1S/C32H32N6O2S/c1-36-15-17-37(18-16-36)30(39)12-6-9-26-21-38(27-10-3-2-4-11-27)32(34-26)35-31(40)25-8-5-7-23(19-25)24-13-14-29-28(20-24)33-22-41-29/h2-5,7-8,10-11,13-14,19-22H,6,9,12,15-18H2,1H3,(H,34,35,40)	OMMQFLBWSQBNDK-UHFFFAOYSA-N	506701	US12534452, Example 284	Interleukin-1 receptor-associated kinase 4	Homo sapiens		>100							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506701	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506701&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			146318498	459091844							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223349	CN1CCN(C(=O)CCCCCc2cn(-c3ccccc3)c(NC(=O)c3cccc(-c4ccc5ncsc5c4)c3)n2)CC1	InChI=1S/C34H36N6O2S/c1-38-17-19-39(20-18-38)32(41)14-7-2-4-11-28-23-40(29-12-5-3-6-13-29)34(36-28)37-33(42)27-10-8-9-25(21-27)26-15-16-30-31(22-26)43-24-35-30/h3,5-6,8-10,12-13,15-16,21-24H,2,4,7,11,14,17-20H2,1H3,(H,36,37,42)	GBLOQGJUHSCSIW-UHFFFAOYSA-N	506703	US12534452, Example 285	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506703	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506703&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			146318445	459091845							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223350	O=C(CCCCCc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3ccc4ncsc4c3)c2)n1)NC1CC1	InChI=1S/C32H31N5O2S/c38-30(34-25-15-16-25)13-6-1-3-10-26-20-37(27-11-4-2-5-12-27)32(35-26)36-31(39)24-9-7-8-22(18-24)23-14-17-28-29(19-23)40-21-33-28/h2,4-5,7-9,11-12,14,17-21,25H,1,3,6,10,13,15-16H2,(H,34,38)(H,35,36,39)	PRLQFQLISLOBEJ-UHFFFAOYSA-N	506704	US12534452, Example 286	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506704	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506704&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			146318469	459091846							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223351	CN(C)C1CCN(C(=O)CCCCCc2cn(-c3ccccc3)c(NC(=O)c3cccc(-c4ccc5ncsc5c4)c3)n2)CC1	InChI=1S/C36H40N6O2S/c1-40(2)30-18-20-41(21-19-30)34(43)15-8-3-5-12-29-24-42(31-13-6-4-7-14-31)36(38-29)39-35(44)28-11-9-10-26(22-28)27-16-17-32-33(23-27)45-25-37-32/h4,6-7,9-11,13-14,16-17,22-25,30H,3,5,8,12,15,18-21H2,1-2H3,(H,38,39,44)	HHKFQAIPMBEMAQ-UHFFFAOYSA-N	506705	US12534452, Example 287	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506705	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506705&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			146318447	459091847							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223352	CN1CCN(C(=O)CCCCCc2cn(-c3ccccc3)c(NC(=O)c3cccc(-c4ccc5scnc5c4)c3)n2)CC1	InChI=1S/C34H36N6O2S/c1-38-17-19-39(20-18-38)32(41)14-7-2-4-11-28-23-40(29-12-5-3-6-13-29)34(36-28)37-33(42)27-10-8-9-25(21-27)26-15-16-31-30(22-26)35-24-43-31/h3,5-6,8-10,12-13,15-16,21-24H,2,4,7,11,14,17-20H2,1H3,(H,36,37,42)	XJORBXYYYDGQIO-UHFFFAOYSA-N	506706	US12534452, Example 288	Interleukin-1 receptor-associated kinase 4	Homo sapiens		>100							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506706	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506706&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			153315623	459091848							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223353	O=C(Nc1nc(CCCCCC(=O)N2CCCCCC2)cn1-c1ccccc1)c1cccc(-c2ccc3scnc3c2)c1	InChI=1S/C35H37N5O2S/c41-33(39-20-9-1-2-10-21-39)17-8-3-5-14-29-24-40(30-15-6-4-7-16-30)35(37-29)38-34(42)28-13-11-12-26(22-28)27-18-19-32-31(23-27)36-25-43-32/h4,6-7,11-13,15-16,18-19,22-25H,1-3,5,8-10,14,17,20-21H2,(H,37,38,42)	HXSOSKUSRQWRCA-UHFFFAOYSA-N	506707	US12534452, Example 289	Interleukin-1 receptor-associated kinase 4	Homo sapiens		>100							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506707	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506707&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			146318357	459091849							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223354	O=C(CCCCCc1cn(-c2ccccc2)c(NC(=O)c2cccc(-c3ccc4scnc4c3)c2)n1)NC1CC1	InChI=1S/C32H31N5O2S/c38-30(34-25-15-16-25)13-6-1-3-10-26-20-37(27-11-4-2-5-12-27)32(35-26)36-31(39)24-9-7-8-22(18-24)23-14-17-29-28(19-23)33-21-40-29/h2,4-5,7-9,11-12,14,17-21,25H,1,3,6,10,13,15-16H2,(H,34,38)(H,35,36,39)	FBMPQNLSSFWXNZ-UHFFFAOYSA-N	506708	US12534452, Example 290	Interleukin-1 receptor-associated kinase 4	Homo sapiens		>100							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506708	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506708&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			146318365	459091850							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223355	CN(C)C1CCN(C(=O)CCCCCc2cn(-c3ccccc3)c(NC(=O)c3cccc(-c4ccc5scnc5c4)c3)n2)CC1	InChI=1S/C36H40N6O2S/c1-40(2)30-18-20-41(21-19-30)34(43)15-8-3-5-12-29-24-42(31-13-6-4-7-14-31)36(38-29)39-35(44)28-11-9-10-26(22-28)27-16-17-33-32(23-27)37-25-45-33/h4,6-7,9-11,13-14,16-17,22-25,30H,3,5,8,12,15,18-21H2,1-2H3,(H,38,39,44)	UXBGFVZERDGFDW-UHFFFAOYSA-N	506709	US12534452, Example 291	Interleukin-1 receptor-associated kinase 4	Homo sapiens		>100							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506709	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506709&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			146318362	459091851							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223356	O=C(CCc1cn(Cc2ccccc2)c(NC(=O)c2cccc(-c3cn[nH]c3)c2)n1)Nc1ccccc1	InChI=1S/C29H26N6O2/c36-27(32-25-12-5-2-6-13-25)15-14-26-20-35(19-21-8-3-1-4-9-21)29(33-26)34-28(37)23-11-7-10-22(16-23)24-17-30-31-18-24/h1-13,16-18,20H,14-15,19H2,(H,30,31)(H,32,36)(H,33,34,37)	SZXDPUCFWKWYDT-UHFFFAOYSA-N	506710	US12534452, Example 292	Interleukin-1 receptor-associated kinase 4	Homo sapiens		>100							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506710	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506710&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			146318358	459091852							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223357	O=C(CCc1cn(-c2cccc(Cl)c2)c(NC(=O)c2cccc(-c3cn[nH]c3)c2)n1)Nc1ccccc1	InChI=1S/C28H23ClN6O2/c29-22-8-5-11-25(15-22)35-18-24(12-13-26(36)32-23-9-2-1-3-10-23)33-28(35)34-27(37)20-7-4-6-19(14-20)21-16-30-31-17-21/h1-11,14-18H,12-13H2,(H,30,31)(H,32,36)(H,33,34,37)	PEYUOMQWGBZNOO-UHFFFAOYSA-N	506711	US12534452, Example 293	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506711	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506711&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			146318452	459091853							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223358	O=C(CCc1cn(-c2cccc(Br)c2)c(NC(=O)c2cccc(-c3cn[nH]c3)c2)n1)Nc1ccccc1	InChI=1S/C28H23BrN6O2/c29-22-8-5-11-25(15-22)35-18-24(12-13-26(36)32-23-9-2-1-3-10-23)33-28(35)34-27(37)20-7-4-6-19(14-20)21-16-30-31-17-21/h1-11,14-18H,12-13H2,(H,30,31)(H,32,36)(H,33,34,37)	XNTWEJHEJRRHBT-UHFFFAOYSA-N	506712	US12534452, Example 294	Interleukin-1 receptor-associated kinase 4	Homo sapiens		 75							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506712	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506712&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			146318450	459091854							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223359	O=C(CCc1cn(CC2CCCCC2)c(NC(=O)c2cccc(-c3cn[nH]c3)c2)n1)Nc1ccccc1	InChI=1S/C29H32N6O2/c36-27(32-25-12-5-2-6-13-25)15-14-26-20-35(19-21-8-3-1-4-9-21)29(33-26)34-28(37)23-11-7-10-22(16-23)24-17-30-31-18-24/h2,5-7,10-13,16-18,20-21H,1,3-4,8-9,14-15,19H2,(H,30,31)(H,32,36)(H,33,34,37)	DXWVHNQKHHXLBG-UHFFFAOYSA-N	506713	US12534452, Example 295	Interleukin-1 receptor-associated kinase 4	Homo sapiens		>100							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506713	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506713&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			153315567	459091855							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223360	CNC(=O)CCCc1cn(C2CCCCC2)c(NC(=O)c2cccc(-c3cn[nH]c3)c2)n1	InChI=1S/C24H30N6O2/c1-25-22(31)12-6-9-20-16-30(21-10-3-2-4-11-21)24(28-20)29-23(32)18-8-5-7-17(13-18)19-14-26-27-15-19/h5,7-8,13-16,21H,2-4,6,9-12H2,1H3,(H,25,31)(H,26,27)(H,28,29,32)	ANXNAUYIRRMYQG-UHFFFAOYSA-N	506714	US12534452, Example 296	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506714	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506714&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			146318451	459091856							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
223361	CNC(=O)CCCc1cn(-c2ccc(F)cc2)c(NC(=O)c2cccc(-c3cn[nH]c3)c2)n1	InChI=1S/C24H23FN6O2/c1-26-22(32)7-3-6-20-15-31(21-10-8-19(25)9-11-21)24(29-20)30-23(33)17-5-2-4-16(12-17)18-13-27-28-14-18/h2,4-5,8-15H,3,6-7H2,1H3,(H,26,32)(H,27,28)(H,29,30,33)	PLYPUJXRBBCKSD-UHFFFAOYSA-N	506715	US12534452, Example 297	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800122	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506715	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506715&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			146318453	459091857							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
226586	CNC(=O)CCCc1cn(-c2ccc(F)cc2F)c(NC(=O)c2cccc(-c3cn[nH]c3)c2)n1	InChI=1S/C24H22F2N6O2/c1-27-22(33)7-3-6-19-14-32(21-9-8-18(25)11-20(21)26)24(30-19)31-23(34)16-5-2-4-15(10-16)17-12-28-29-13-17/h2,4-5,8-14H,3,6-7H2,1H3,(H,27,33)(H,28,29)(H,30,31,34)	BURHPYCVVDVFDG-UHFFFAOYSA-N	506716	US12534452, Example 298	Interleukin-1 receptor-associated kinase 4	Homo sapiens		 75							US Patent		10.7270/Q27P946F		aid1800172	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506716	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506716&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			146318508	459091858							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
226587	CN1CCN(C(=O)CCCc2cn(-c3ccc(F)cc3)c(NC(=O)c3cccc(-c4cnn(C)c4)c3)n2)CC1	InChI=1S/C29H32FN7O2/c1-34-13-15-36(16-14-34)27(38)8-4-7-25-20-37(26-11-9-24(30)10-12-26)29(32-25)33-28(39)22-6-3-5-21(17-22)23-18-31-35(2)19-23/h3,5-6,9-12,17-20H,4,7-8,13-16H2,1-2H3,(H,32,33,39)	FQYGBEANUPGBMB-UHFFFAOYSA-N	506717	US12534452, Example 299	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800172	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506717	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506717&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			146318510	459091859							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
226588	Cn1cc(-c2cccc(C(=O)Nc3nc(CCCC(=O)NC4CC4)cn3-c3ccc(F)cc3)c2)cn1	InChI=1S/C27H27FN6O2/c1-33-16-20(15-29-33)18-4-2-5-19(14-18)26(36)32-27-31-23(6-3-7-25(35)30-22-10-11-22)17-34(27)24-12-8-21(28)9-13-24/h2,4-5,8-9,12-17,22H,3,6-7,10-11H2,1H3,(H,30,35)(H,31,32,36)	QUKQFSICCUVHHN-UHFFFAOYSA-N	506718	US12534452, Example 300	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800172	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506718	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506718&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			147419518	459091860							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
226589	O=C(Nc1nc(CCCCCCN2CCCCC2)cn1-c1ccc(F)cc1)c1cccc(-c2cn[nH]c2)c1	InChI=1S/C30H35FN6O/c31-26-12-14-28(15-13-26)37-22-27(11-4-1-2-5-16-36-17-6-3-7-18-36)34-30(37)35-29(38)24-10-8-9-23(19-24)25-20-32-33-21-25/h8-10,12-15,19-22H,1-7,11,16-18H2,(H,32,33)(H,34,35,38)	WNGKOCNTNBXDTR-UHFFFAOYSA-N	506719	US12534452, Example 301	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<50							US Patent		10.7270/Q27P946F		aid1800172	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506719	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506719&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			147705074	459091861							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
226590	O=C(Nc1nc(CCCCCCN2CCCCC2)cn1-c1ccc(F)cc1F)c1cccc(-c2cn[nH]c2)c1	InChI=1S/C30H34F2N6O/c31-25-12-13-28(27(32)18-25)38-21-26(11-4-1-2-5-14-37-15-6-3-7-16-37)35-30(38)36-29(39)23-10-8-9-22(17-23)24-19-33-34-20-24/h8-10,12-13,17-21H,1-7,11,14-16H2,(H,33,34)(H,35,36,39)	YNWRIUVRCGQCRR-UHFFFAOYSA-N	506720	US12534452, Example 302	Interleukin-1 receptor-associated kinase 4	Homo sapiens		>100							US Patent		10.7270/Q27P946F		aid1800172	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506720	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506720&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			146318512	459091862							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
226591	O=C(CCc1cn(-c2ccncc2)c(NC(=O)c2cccc(-c3cn[nH]c3)c2)n1)Nc1ccccc1	InChI=1S/C27H23N7O2/c35-25(31-22-7-2-1-3-8-22)10-9-23-18-34(24-11-13-28-14-12-24)27(32-23)33-26(36)20-6-4-5-19(15-20)21-16-29-30-17-21/h1-8,11-18H,9-10H2,(H,29,30)(H,31,35)(H,32,33,36)	ANYBPCTZCPADMJ-UHFFFAOYSA-N	506721	US12534452, Example 303	Interleukin-1 receptor-associated kinase 4	Homo sapiens		>100							US Patent		10.7270/Q27P946F		aid1800172	US12534452	Chung, J; Kim, S; Cho, H; Min, J	1/27/2026	6/8/2026	Kainos Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506721	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506721&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			146318359	459091863							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589